Areas Christopher Love is Knowledgeable in:
Synthetic organic chemistry.
Synthetic equivalents (chemistry).
Medicinal chemistry.
Techniques Christopher Love Uses:
Synthetic organic chemistry, Principal Component Analysis, some Cluster Analysis. Data collation, storage (MS Access, some Oracle), presentation & reporting (Spotfire/Excel/PowerPoint)
Christopher Love's Problem Solving Skills:
- multivariate analysis & design
- Highly computer literate (MS Office, SIMCA, MODDE, Spotfire, SciFinder, Reaxsys, chemistry drawing packages, some Oracle, Pipel
- Synthetic organic chemistry, medicinal chemistry
- Motivation/leadership of team members
Christopher Love's Problem Solving Experience:
- Improved communication to senior management by creating flexible, updateable helicopter view of structural plus vitro-to-PK data (12 dimensional).
- Initiated and led a medicinal chemistry/pharmacology/modelling program to apply multivariate design to explore ligand diversity more efficiently.
- Took project in two years from high-throughput screening results to late lead optimization. My original analysis withstood repeated challenge, and therefore less valuable series were not pursued
- Increased potency of a chemical hit by 1000 in two months. Cellular toxicity also resolved.
- Key synthetic organic chemistry challenge resolved; later implemented on a multi-kilogram scale
- Learned and implemented the latest thinking on physicochemistry to deliver bioavailability for a chemical series considered very difficult by my superiors.
- Can routinely resolve issues with (chemical) compound claims on competitor patent portfolios - I am co-inventor as discovery medicinal chemist on 13 patents.
- Directed an external team of six chemists to execute critical chemistry for a project in lead optimization.