Monitoring process-related impurity clearance in biopharmaceutical production processes. I am knowledgeable in mammalian cell culture methods and immunologically-based diagnostic methods (fluid and tissue-based).
Techniques Brian Lentrichia Uses:
DoE (Design of Experiment) optimization methods. Familiar with JMP software toward that end.
Brian Lentrichia's Problem Solving Skills:
Brian Lentrichia's Problem Solving Experience:
I have 8 issues US patents covering micro-particle technology for diagnostic assays, and Human Papilloma virus detection and genotyping using molecular techniques. I have developed a novel cell-based relative potency determination method for carbohydrate-mediated internalization of biomolecules using a scintillation proximity assay. I have developed numerous immunoassays and immunohistochemistry methods for large and small molecules using ELISA methods with a variety of read-outs.