Problem Solver
Mohsen Rajabi
Areas Mohsen Rajabi is Knowledgeable in:
• Developing the analytical protocols including SPR, Mass Spec to evaluate the efficacy and biosafety of the pharmaceutical products.
• Studying the metabolites of the pharmaceutical products using the state of the art technologies including Biacore and Fortebio systems.
• Studying the toxicity of antimicrobial peptide against pathogens using vCC assay.
• Biological chemistry with emphasis on discovery of structures and functions of organic & biological molecules, detection of biomarkers, metabolites using ESI-MS, MALDI-TOF, Circular Dichroism and fluorescence spectroscopy.
• Chemical synthesis of peptide & organic molecules: Synthesis of therapeutic peptides and organic molecules against infectious diseases and cancer.
• Biological analytical chemistry: Development of ultra-sensitive enzyme-linked immunosorbent assay (ELISA) for biological molecules
• Studying the metabolites of the pharmaceutical products using the state of the art technologies including Biacore and Fortebio systems.
• Studying the toxicity of antimicrobial peptide against pathogens using vCC assay.
• Biological chemistry with emphasis on discovery of structures and functions of organic & biological molecules, detection of biomarkers, metabolites using ESI-MS, MALDI-TOF, Circular Dichroism and fluorescence spectroscopy.
• Chemical synthesis of peptide & organic molecules: Synthesis of therapeutic peptides and organic molecules against infectious diseases and cancer.
• Biological analytical chemistry: Development of ultra-sensitive enzyme-linked immunosorbent assay (ELISA) for biological molecules
Techniques Mohsen Rajabi Uses:
searching literatures for existing knowledge, using my background
Mohsen Rajabi's Problem Solving Skills:
- UV/Vis spectroscopy
- HPLC
- Enzyme kinetics
- Peptide purification
- Solid-Phase peptide synthesis
- Mass spectrometry
- Surface Plasmon Resonance (SPR)
- Fluorescence Spectrsocopy
- Circular Dichroism (CD)
- vCC Bacterial assay
Mohsen Rajabi's Problem Solving Experience:
- • Studied the adverse effects of impurities in heparin product using SPR.
• Studied the role of glycosaminoglycans in the activation of complement and contact system proteins by surface plasmon resonance.
• Applied surface plasmon resonance technique to evaluate the binding of hydrophobic ligands to human serum albumin.
• Studied the molecular determinant in human α-defensin biological function. An in vitro study to design an antimicrobial therapeutic peptide.
• Identified the Salt Bridge and its critical role in the stability of human α-defensins.
• Examined the role of cationic residues for the biological activity of human α-defensin 5.
• Synthesized and characterized crotamine, a toxin present in the venom of the South American rattlesnake.