Patent Holder
Stefano Biondi 
Proven Solver
1) New angiotensin ii receptor blocker derivatives.
Nicox S.A., Fr; Merck & Co., Inc., USA
Publised on: 03 September 2009 as WO 2009106471.
Inventors: Almirante, Nicoletta; Nicotra, Alessia; Mandelli, Valentino; Biondi, Stefano; Stefanini, Silvia; Sebhat, Iyassu K.; Lo, Michael Man-Chu.
2) Angiotensin ii receptor antagonists.
Nicox S.A., Fr; Merck & Co., Inc., USA
Publised on: 03 September 2009 as WO 2009106470.
Inventors: Almirante, Nicoletta; Nicotra, Alessia; Stefanini, Silvia; Biondi, Stefano; Ongini, Ennio; Ali, Amjad; Lo, Michael Man-Chu.
3) Nitric oxide donor compounds and their preparation and use in the mono- and combination therapy of diseases.
Nicox S.A., Fr.
Publised on: 33 August 2009 as WO 2009098113.
Inventors: , Nicoletta; Stefanini, Silvia; Storoni, Laura; Nicoli, Fabio; Padron, Julio Lazaro; Biondi, Stefano,
4) Angiotensin II receptor antagonists.
Merck & Co., Inc., USA; Nicox S.A.
Publised on: 04 June 2009 as WO 2009070241.
Inventors: Ali, Amjad; Lo, Michael Man-Chu; Franklin, Chris; Almirante, Nicoletta; Stefanini, Silvia; Storoni, Laura; Biondi, Stefano; Ongini, Ennio.
5) Preparation of new NO-donor aspirin derivatives having antiinflammatory, antithrombotic and antiplatelet activity.
Nicox S.A., Fr.
Published on: 23 April 2009 as WO 2009049961.
Inventors: Fruttero, Roberta; Gasco, Alberto; Lazzarato, Loretta; Donnola, Monica; Rolando, Barbara; Biondi, Stefano.
6) Preparation of nitro derivatives of non-peptidic renin inhibitors for the treatment of cardiovascular, renal and chronic liver disease, inflammations and metabolic syndrome.
Nicox S. A., Fr.
Published on: 30 October 2008 as WO 2008128832.
Inventors: Almirante, Nicoletta; Biondi, Stefano; Ongini, Ennio.
7) Crystalline forms of atorvastatin 4-(nitrooxy)butyl ester.
Nicox S.A., Fr.
Published on: 23 October 2008 as WO 2008125412.
Inventors: Benedini, Francesca; Biondi, Stefano; Bonfanti, Annalisa; Nicoli, Fabio
8) Synthesis of nitric oxide releasing steroids.
Nicox S. A., Fr.
Published on: 14 August2008 as WO 2008095808.
Inventors: Benedini, Francesca; Biondi, Stefano; Ongini, Ennio.
9) Preparation of nitric oxide releasing steroids.
Nicox S. A., Fr.
Published on: 14 August 2008 as WO 2008095806.
Inventors: Benedini, Francesca; Biondi, Stefano; Ongini, Ennio.
10) Nitric oxide releasing corticosteroids.
Nicox S. A., Fr.
Published on: 14 August 2008 as WO 2008095809.
Inventors: Benedini, Francesca; Biondi, Stefano; Ongini, Ennio.
11) Nitric oxide donor compounds and their preparation and use in the treatment of diseases.
Nicox S. A., Fr.
Published on: 14 August 2008 as WO 2008095841.
Inventors: Almirante, Nicoletta; Biondi, Stefano; Ongini, Ennio; Storoni, Laura; Nicotra, Alessia.
12) Piperidine-nitro derivatives as nonpeptidic renin inhibitors, their pharmaceutical compositions and use in the treatment of diseases.
Nicox S.A., Fr.
Published on: 26 June 2008 as WO 2008074450.
Inventors: Almirante, Nicoletta; Biondi, Stefano; Ongini, Ennio.
13) Preparation of dorzolamide derivatives as nitric oxide-releasing carbonic anhydrase inhibitors.
Nicox S.A., Fr.; Pfizer Inc.
Published on: 26 June 2008 as WO 2008075155.
Inventors: Benedini, Francesca; Biondi, Stefano; Ongini, Ennio.
14) Preparation of nitrate esters of (hetero)arylsulfonamide carbonic anhydrase inhibitors as agents for treating eye disorders and cancer.
Nicox S.A., Fr.
Published on: 19 June 2008 as WO 2008071421.
Inventors: Supuran, Claudiu; Benedini, Francesca; Biondi, Stefano; Ongini, Ennio.
15) New nitrated heterocycle compounds are endothelin receptor antagonists - useful for the prevention and treatment of eg congestive heart failure, stroke, atherosclerosis, renal failure, erectile dysfunction and sickle cell disease.
NicOx SA
Published on 06 December 2007 as WO-2007137980.
Inventors: Almirante Nicoletta, Biondi Stefano, Ongini Ennio
16) New non-peptidic nitro compounds are renin inhibitors - useful for treating and preventing cardiovascular, renal and chronic liver diseases, inflammation and metabolic syndrome.
NicOx SA
Published on 20 September 2007 as WO-2007104652.
Inventors: Almirante Nicoletta, Biondi Stefano, Ongini Ennio
17) New nitrooxy derivatives are alpha-2 adrenergic receptor agonists - useful for the prevention and treatment of cardiovascular diseases such as systemic hypertension, stroke, atherosclerosis and hyperlipidemia.
NicOx SA
Published on 16 August 2007 as WO 2007090733.
Inventors: Almirante Nicoletta, Monopoli Angela, Biondi Stefano, Ongini Ennio
18) New nitrooxy derivatives of apraclonidine and brimonidine are alpha-2 adrenergic receptor agonists - useful for the prevention and treatment of ocular diseases such as high intraocular pressure and glaucoma.
NicOx SA; Pfizer Inc
Published on 16 August 2007 as WO 2007090793.
Inventors: Benedini Francesca, Impagnatiello Francesco, Biondi Stefano, Ongini Ennio, Chong Wesley Kwan Mung.
19) Preparation of benzodiazepine derivatives having PDE2 inhibitory activities.
Neuro3d, Fr.
Published on: 07 February 2007 as EP 1749824.
Inventors: Abarghaz, Mustapha; Biondi, Stefano; Duranton, Jerome; Mondadori, Cesare; Wagner, Patrick.
20) Ocaperidone salts and pharmaceutical compositions containing the same.
Neuro3d, Fr.
Published on: 31 August 2006 as WO 2006090285.
Inventors: Biondi, Stefano; Demailly, Arnold; Mondadori, Cesare; Paparin, Jean-Laurent.
21) Oral composition comprising antipsychotic drug ocaperidone and water-soluble polymers.
Neuro3d, Fr.
Published on: 16 August 2006 as EP 1690540.
Inventors: Khanna, Satish; Mondadori, Cesare; Biondi, Stefano; Demailly, Arnold; Paparin, Jean-Laurent.
22) Preparation of benzo[1,4]diazepin-2-one derivatives as phosphodiesterase PDE2 inhibitors.
Neuro3d SA.
Published on: 29 June 2005 as EP 1548011.
Inventors: Abarghaz, Mustafa; Biondi, Stefano; Duranton, Jerome; Limanton, Emmanuelle; Mondadori, Cesare; Wagner, Patrick.
23) Bicycloheptane derivatives for treatment of psychological conditions, cognition disturbances, fibromyagia, sleep disorders and autism.
Neuro3d SA.
Published on: 26 January 2005 as EP 1500391.
Inventors: Mondadori, Cesare; Paparin, Jean Laurent; Biondi, Stefano; Joseph, Christophe.
24) Preparation of macrolides with antibacterial activity.
Glaxo Group Limited, UK; Pliva D.D.
Published on: PCT 22 May 2003 as WO 2003042228.
Inventors: Alihodzic, Sulejman; Andreotti, Daniele; Berdik, Andrea; Bientinesi, Ilaria; Biondi, Stefano; Ciraco, Manuela; Damiani, Federica; Djerek, Marko; Dumic, Milenko; Erakovic, Vesna; Hutinec, Antun; Lazarevski, Gorjana; Lociuro, Sergio, Marsic, Natasa; Marusic-istuk, Zorica;Mutak, Stjepan; Paio, Alfredo; Pavlovic, Drazen; Quaglia, Anna Maria; Schoenfeld, Wolfgang; Stimac, Vlado; Tibasco, Jessica.
25) Preparation of lactone ketolide macrolide erythromycin antibiotics.
Glaxo Group Limited, UK
Published on: 27 June 2002 as WO 2002050092
Inventors: Andreotti, Daniele; Biondi, Stefano; Lociuro.
26) Preparation of lactone ketolide macrolide erythromycin antibiotics.
Glaxo Group Limited, UK
Published on: 27 June 2002 as WO 2002050091.
Inventors: Andreotti, Daniele; Arista, Luca; Biondi, Stefano; Cardullo, Francesca; Damiani, Frederica; Lociuro, Sergio; Marchioro, Carla; Merlo, Giancarlo; Mingardi, Anna; Niccolai, Daniela; Paio, Alfredo; Piga, Elisabetta; Pozzan, Alfonso; Seri, Catia; Tarsi, Luca; Terreni, Silvia; Tibasco, Jessica.
27) Preparation and antibacterial activity of tricyclic carbapenem compounds.
Glaxo Wellcome S.p.A.
Published on: 22 May 1998 as WO 9821210.
Inventors: Rossi, Tino; Andreotti, Daniele; Tedesco, Giovanna; Tarsi, Luca; Ratti, Emiliangelo; Feriani, Aldo; Pizzi, Domenica Antonia; Gaviraghi, Giovari; Biondi, Stefano; Finizia, Gabriella
28) Preparation of 4-(3-cyclohexenyl)-2-azetidinones.
Glaxo S.p.A.
Published on: 28 September 1994 as EP 94-200692.
Inventors: Thomas, Russell John; Biondi, Stefano; Rossi, Tino; Contini, Stefania Anna.
29) Preparation of 4-(3-cyclohexenyl)-2-azetidinones.
Glaxo S.p.A.
Published on: 28 September 1994 as EP 617017.
Inventors: Biondi, Stefano; Rossi, Tino; Contini, Stefania Anna.
30) Preparation of anellated carbapensems as antibiotics.
Glaxo S.p.A.
Published on: 09 September 1992
Inventors: Biondi, Stefano; Andreotti, Daniele; Rossi, Tino; Carlesso, Robert; Tarzia, Giorgio; Perboni, Alcide.
31) Microbial manufacture of cyclic ketal derivatives for use as anticholesterolemics and fungicides.
Glaxo Group Ltd., UK
Published on: 23 July 1992 as WO 9212158.
Inventors: Sidebottom, Philip James; Lester, Michael George; Procopiou, Panayiotis Alexandrou; Watson, Nigel Stephen; Biondi, Stefano; Ramsay, Michael Vincent John; Livermore, David George Hubert; Ross, Barry Clive.
32) Preparation of 4-(2-oxocyclohexyl)azetidin-2-one derivatives as intermediates for antibiotics.
Glaxo S.p.A.
Published on: 13 March 1991 as EP 416952.
Inventors: Tamburini, Bruno; Perboni, Alcide; Rossi, Tino; Donati, Daniele; Andreotti, Daniele; Gaviraghi, Giovanni; Biondi, Stefano; Bismara, Claudio.
Nicox S.A., Fr; Merck & Co., Inc., USA
Publised on: 03 September 2009 as WO 2009106471.
Inventors: Almirante, Nicoletta; Nicotra, Alessia; Mandelli, Valentino; Biondi, Stefano; Stefanini, Silvia; Sebhat, Iyassu K.; Lo, Michael Man-Chu.
2) Angiotensin ii receptor antagonists.
Nicox S.A., Fr; Merck & Co., Inc., USA
Publised on: 03 September 2009 as WO 2009106470.
Inventors: Almirante, Nicoletta; Nicotra, Alessia; Stefanini, Silvia; Biondi, Stefano; Ongini, Ennio; Ali, Amjad; Lo, Michael Man-Chu.
3) Nitric oxide donor compounds and their preparation and use in the mono- and combination therapy of diseases.
Nicox S.A., Fr.
Publised on: 33 August 2009 as WO 2009098113.
Inventors: , Nicoletta; Stefanini, Silvia; Storoni, Laura; Nicoli, Fabio; Padron, Julio Lazaro; Biondi, Stefano,
4) Angiotensin II receptor antagonists.
Merck & Co., Inc., USA; Nicox S.A.
Publised on: 04 June 2009 as WO 2009070241.
Inventors: Ali, Amjad; Lo, Michael Man-Chu; Franklin, Chris; Almirante, Nicoletta; Stefanini, Silvia; Storoni, Laura; Biondi, Stefano; Ongini, Ennio.
5) Preparation of new NO-donor aspirin derivatives having antiinflammatory, antithrombotic and antiplatelet activity.
Nicox S.A., Fr.
Published on: 23 April 2009 as WO 2009049961.
Inventors: Fruttero, Roberta; Gasco, Alberto; Lazzarato, Loretta; Donnola, Monica; Rolando, Barbara; Biondi, Stefano.
6) Preparation of nitro derivatives of non-peptidic renin inhibitors for the treatment of cardiovascular, renal and chronic liver disease, inflammations and metabolic syndrome.
Nicox S. A., Fr.
Published on: 30 October 2008 as WO 2008128832.
Inventors: Almirante, Nicoletta; Biondi, Stefano; Ongini, Ennio.
7) Crystalline forms of atorvastatin 4-(nitrooxy)butyl ester.
Nicox S.A., Fr.
Published on: 23 October 2008 as WO 2008125412.
Inventors: Benedini, Francesca; Biondi, Stefano; Bonfanti, Annalisa; Nicoli, Fabio
8) Synthesis of nitric oxide releasing steroids.
Nicox S. A., Fr.
Published on: 14 August2008 as WO 2008095808.
Inventors: Benedini, Francesca; Biondi, Stefano; Ongini, Ennio.
9) Preparation of nitric oxide releasing steroids.
Nicox S. A., Fr.
Published on: 14 August 2008 as WO 2008095806.
Inventors: Benedini, Francesca; Biondi, Stefano; Ongini, Ennio.
10) Nitric oxide releasing corticosteroids.
Nicox S. A., Fr.
Published on: 14 August 2008 as WO 2008095809.
Inventors: Benedini, Francesca; Biondi, Stefano; Ongini, Ennio.
11) Nitric oxide donor compounds and their preparation and use in the treatment of diseases.
Nicox S. A., Fr.
Published on: 14 August 2008 as WO 2008095841.
Inventors: Almirante, Nicoletta; Biondi, Stefano; Ongini, Ennio; Storoni, Laura; Nicotra, Alessia.
12) Piperidine-nitro derivatives as nonpeptidic renin inhibitors, their pharmaceutical compositions and use in the treatment of diseases.
Nicox S.A., Fr.
Published on: 26 June 2008 as WO 2008074450.
Inventors: Almirante, Nicoletta; Biondi, Stefano; Ongini, Ennio.
13) Preparation of dorzolamide derivatives as nitric oxide-releasing carbonic anhydrase inhibitors.
Nicox S.A., Fr.; Pfizer Inc.
Published on: 26 June 2008 as WO 2008075155.
Inventors: Benedini, Francesca; Biondi, Stefano; Ongini, Ennio.
14) Preparation of nitrate esters of (hetero)arylsulfonamide carbonic anhydrase inhibitors as agents for treating eye disorders and cancer.
Nicox S.A., Fr.
Published on: 19 June 2008 as WO 2008071421.
Inventors: Supuran, Claudiu; Benedini, Francesca; Biondi, Stefano; Ongini, Ennio.
15) New nitrated heterocycle compounds are endothelin receptor antagonists - useful for the prevention and treatment of eg congestive heart failure, stroke, atherosclerosis, renal failure, erectile dysfunction and sickle cell disease.
NicOx SA
Published on 06 December 2007 as WO-2007137980.
Inventors: Almirante Nicoletta, Biondi Stefano, Ongini Ennio
16) New non-peptidic nitro compounds are renin inhibitors - useful for treating and preventing cardiovascular, renal and chronic liver diseases, inflammation and metabolic syndrome.
NicOx SA
Published on 20 September 2007 as WO-2007104652.
Inventors: Almirante Nicoletta, Biondi Stefano, Ongini Ennio
17) New nitrooxy derivatives are alpha-2 adrenergic receptor agonists - useful for the prevention and treatment of cardiovascular diseases such as systemic hypertension, stroke, atherosclerosis and hyperlipidemia.
NicOx SA
Published on 16 August 2007 as WO 2007090733.
Inventors: Almirante Nicoletta, Monopoli Angela, Biondi Stefano, Ongini Ennio
18) New nitrooxy derivatives of apraclonidine and brimonidine are alpha-2 adrenergic receptor agonists - useful for the prevention and treatment of ocular diseases such as high intraocular pressure and glaucoma.
NicOx SA; Pfizer Inc
Published on 16 August 2007 as WO 2007090793.
Inventors: Benedini Francesca, Impagnatiello Francesco, Biondi Stefano, Ongini Ennio, Chong Wesley Kwan Mung.
19) Preparation of benzodiazepine derivatives having PDE2 inhibitory activities.
Neuro3d, Fr.
Published on: 07 February 2007 as EP 1749824.
Inventors: Abarghaz, Mustapha; Biondi, Stefano; Duranton, Jerome; Mondadori, Cesare; Wagner, Patrick.
20) Ocaperidone salts and pharmaceutical compositions containing the same.
Neuro3d, Fr.
Published on: 31 August 2006 as WO 2006090285.
Inventors: Biondi, Stefano; Demailly, Arnold; Mondadori, Cesare; Paparin, Jean-Laurent.
21) Oral composition comprising antipsychotic drug ocaperidone and water-soluble polymers.
Neuro3d, Fr.
Published on: 16 August 2006 as EP 1690540.
Inventors: Khanna, Satish; Mondadori, Cesare; Biondi, Stefano; Demailly, Arnold; Paparin, Jean-Laurent.
22) Preparation of benzo[1,4]diazepin-2-one derivatives as phosphodiesterase PDE2 inhibitors.
Neuro3d SA.
Published on: 29 June 2005 as EP 1548011.
Inventors: Abarghaz, Mustafa; Biondi, Stefano; Duranton, Jerome; Limanton, Emmanuelle; Mondadori, Cesare; Wagner, Patrick.
23) Bicycloheptane derivatives for treatment of psychological conditions, cognition disturbances, fibromyagia, sleep disorders and autism.
Neuro3d SA.
Published on: 26 January 2005 as EP 1500391.
Inventors: Mondadori, Cesare; Paparin, Jean Laurent; Biondi, Stefano; Joseph, Christophe.
24) Preparation of macrolides with antibacterial activity.
Glaxo Group Limited, UK; Pliva D.D.
Published on: PCT 22 May 2003 as WO 2003042228.
Inventors: Alihodzic, Sulejman; Andreotti, Daniele; Berdik, Andrea; Bientinesi, Ilaria; Biondi, Stefano; Ciraco, Manuela; Damiani, Federica; Djerek, Marko; Dumic, Milenko; Erakovic, Vesna; Hutinec, Antun; Lazarevski, Gorjana; Lociuro, Sergio, Marsic, Natasa; Marusic-istuk, Zorica;Mutak, Stjepan; Paio, Alfredo; Pavlovic, Drazen; Quaglia, Anna Maria; Schoenfeld, Wolfgang; Stimac, Vlado; Tibasco, Jessica.
25) Preparation of lactone ketolide macrolide erythromycin antibiotics.
Glaxo Group Limited, UK
Published on: 27 June 2002 as WO 2002050092
Inventors: Andreotti, Daniele; Biondi, Stefano; Lociuro.
26) Preparation of lactone ketolide macrolide erythromycin antibiotics.
Glaxo Group Limited, UK
Published on: 27 June 2002 as WO 2002050091.
Inventors: Andreotti, Daniele; Arista, Luca; Biondi, Stefano; Cardullo, Francesca; Damiani, Frederica; Lociuro, Sergio; Marchioro, Carla; Merlo, Giancarlo; Mingardi, Anna; Niccolai, Daniela; Paio, Alfredo; Piga, Elisabetta; Pozzan, Alfonso; Seri, Catia; Tarsi, Luca; Terreni, Silvia; Tibasco, Jessica.
27) Preparation and antibacterial activity of tricyclic carbapenem compounds.
Glaxo Wellcome S.p.A.
Published on: 22 May 1998 as WO 9821210.
Inventors: Rossi, Tino; Andreotti, Daniele; Tedesco, Giovanna; Tarsi, Luca; Ratti, Emiliangelo; Feriani, Aldo; Pizzi, Domenica Antonia; Gaviraghi, Giovari; Biondi, Stefano; Finizia, Gabriella
28) Preparation of 4-(3-cyclohexenyl)-2-azetidinones.
Glaxo S.p.A.
Published on: 28 September 1994 as EP 94-200692.
Inventors: Thomas, Russell John; Biondi, Stefano; Rossi, Tino; Contini, Stefania Anna.
29) Preparation of 4-(3-cyclohexenyl)-2-azetidinones.
Glaxo S.p.A.
Published on: 28 September 1994 as EP 617017.
Inventors: Biondi, Stefano; Rossi, Tino; Contini, Stefania Anna.
30) Preparation of anellated carbapensems as antibiotics.
Glaxo S.p.A.
Published on: 09 September 1992
Inventors: Biondi, Stefano; Andreotti, Daniele; Rossi, Tino; Carlesso, Robert; Tarzia, Giorgio; Perboni, Alcide.
31) Microbial manufacture of cyclic ketal derivatives for use as anticholesterolemics and fungicides.
Glaxo Group Ltd., UK
Published on: 23 July 1992 as WO 9212158.
Inventors: Sidebottom, Philip James; Lester, Michael George; Procopiou, Panayiotis Alexandrou; Watson, Nigel Stephen; Biondi, Stefano; Ramsay, Michael Vincent John; Livermore, David George Hubert; Ross, Barry Clive.
32) Preparation of 4-(2-oxocyclohexyl)azetidin-2-one derivatives as intermediates for antibiotics.
Glaxo S.p.A.
Published on: 13 March 1991 as EP 416952.
Inventors: Tamburini, Bruno; Perboni, Alcide; Rossi, Tino; Donati, Daniele; Andreotti, Daniele; Gaviraghi, Giovanni; Biondi, Stefano; Bismara, Claudio.