Cancer Immunology, Lupus immunology, HIV immunology
Techniques Stephen Mathew Uses:
- Critical thinking skills to solve complex problems.
- Advanced molecular biology and immunology techniques to solve experimental problems and proof of concept.
- Online resources and profiling of databases.
- Grant writing skills to develop innovative solutions to complex problems.
Stephen Mathew's Problem Solving Skills:
Stephen Mathew's Problem Solving Experience:
I have identified the role of immune receptor CS1 that has therapeutic implications in systemic lupus erythematosus (SLE) patients.
I demonstrated the inhibitory role of 2B4+ CD8+ T cells against HIV epitopes presumably promoting the HIV viral escape mechanisms and AIDS progression. This innovation is currently being filed for patent.
I identified two key aminoacids Lysine and Glutamic acid that plays a critical role in the interaction of a Natural killer (NK) cell receptor 2B4 with its ligand subsequently activating NK cells to kill tumor cells.