Patent Holder
Alok Khullar
1. Glycidyl amine epoxy resins based on non-carcinogenic AMES negative amines
Quick View
By Dubey, Pradip Kumar; Khullar, Alok; Suckley, Daniel; Naiyawat, Thipa; Noiphom, Nok; Kunwong, Dapawan; Samuthsen, Patcharin; Chamongkolpradit, Worakan; Noghan, Suphansa; Changsarn, Nalintip
From Indian Pat. Appl. (2019), IN 201711036901 A 20190621. | Language: English, Database: CAPLUS
The invention relates to a glycidyl amine epoxy resin obtained by reaction of a diamine with epichlorohydrin, wherein diamine has at least two amine group with at least one labile hydrogen on each nitrogen; at least one nitrogen atom is directly attached to an arom. ring on one side; at least 1 amine group is hindered amine either due to hindered arom. ring having at least one substitution on ring at ortho position to carbon which is directly attached to amine group or due to branched aliph. carbon directly attached to amine group; wherein the diamine is AMES neg. A curable coating system com...
~0
2. Glycidyl amine epoxy resins based on non-carcinogenic AMES negative amines
Quick View
By Dubey, Pradip Kumar; Khullar, Alok; Suckley, Daniel; Naiyawat, Thipa; Noiphom, Nok; Kunwong, Dapawan; Samuthsen, Patcharin; Chamongkolpradit, Worakan; Noghan, Suphansa; Changsarn, Nalintip
From PCT Int. Appl. (2019), WO 2019077523 A1 20190425. | Language: English, Database: CAPLUS
The invention relates to a glycidyl amine epoxy resin obtained by reaction of a diamine with epichlorohydrin, wherein diamine has at least two amine group with at least one labile hydrogen on each nitrogen; at least one nitrogen atom is directly attached to an arom. ring on one side; at least 1 amine group is hindered amine either due to hindered arom. ring having at least one substitution on ring at ortho position to carbon which is directly attached to amine group or due to branched aliph. carbon directly attached to amine group; wherein the diamine is AMES neg. A curable coating system com...
~0
3. Energy efficient manufacturing process for preparing N,O-triglycidyl aminophenols useful for synthesis of epoxy resins
Quick View
By Dubey Pradip, Kumar; Khullar, Alok; Nayawat, Thipa; Visatsingh, Kamonsun; Samuthsen, Patcharin; Samant, Prashant
From PCT Int. Appl. (2015), WO 2015174936 A1 20151119. | Language: English, Database: CAPLUS
The invention relates to an improved process for making monomeric triglycidyl compds., wherein the triglycidyl compds. include N, O-triglycidyl compds. contg. at least one primary arom. amine and one phenolic functional group attached to the same or a different arom. ring. The methods of the present invention result in the prodn. of N, O-triglycidyl compds., such as those of formula I and II; wherein: R1 and R2 are each independently selected from the group consisting of hydrogen, halogen, or Ci-Q alkyl; R and R' are each independently selected from the group consisting of hydrogen, GVQ alkyl...
~0
4. Improved manufacturing process for dihydroxydiphenylmethane with high selectivity for 2,4'-dihydroxydiphenylmethane by reacting phenol and formaldehyde in the presence of polyprotic inorganic acid catalyst
Quick View
By Dubey Pradip, Kumar; Khullar, Alok; Naiyawat, Thipa; Visatsingh, Kamonsun; Samuthsen, Patcharin; Mathure, Pankaj
From PCT Int. Appl. (2015), WO 2015041614 A1 20150326. | Language: English, Database: CAPLUS
The invention relates to a process for manufg. dihydroxydiphenylmethane, comprising reacting phenol with formaldehyde and a polyprotic inorg. acid catalyst in a heterogeneous phase at a temp. of 85 - 100° and recovering the inorg. acid catalyst. The invention also relates to a compn., comprising at least 88 mol% of dihydroxydiphenylmethanes, wherein at least 58 mol% of dihydroxydiphenylmethane is 2,2'- bis(hydroxyphenyl)methane and 2,4'-bis(hydroxyphenyl)methane.
~1
5. An improved process for preparing deltamethrin, (S)-α-cyano-3-phenoxybenzyl-(1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane carboxylate from δ-3-carene
Quick View
By Khullar, Alok; Kumar, Inder; Sharma, Rajeev Kumar; Sharma, Sudhir Kumar; Srivastava, Dhananjay; Ranjan; Madhusoodanan, S.
From Indian Pat. Appl. (2014), IN 2002DE00766 A 20140207. | Language: English, Database: CAPLUS
This invention relates to a process for prepg. deltamethrin (I) comprising: prepg. δ-3-caren-5-one (II) by oxidizing δ-3-carene (III) in the presence of air/oxygen and cobalt pyridinium halide catalyst and subsequently isolating II through continuous distn. and fractionation;. Subjecting the said II in a polar/non-polar solvent to ozonolysis followed by quenching with aq. sodium sulfite soln. to obtain crude C9-Ketoacid IV in a known manner, purifying the said IV;. Stirring the said purified IV with an acid anhydride and para-toluenesulfonic acid catalyst until lactonization is complete;. I...
~0
6. Process for the preparation of the enol lactone of (-)-1R-2,2-dimethyl-3-(2-oxopropyl)cyclopropanecarboxylic acid from (-)-1R-cis-2,2-dimethyl-3-(2'-oxopropyl)cyclopropanecarboxylic acid
Quick View
By Khullar, Alok; Pandey, Inder Kumar; Sharma, Rajeev Kumar; Sharma, Sudhir Kumar; Shrivastava, Dhananjay; Rajaram; Madhusoodanan, S.
From Indian (2002), IN 188414 B 20020921. | Language: English, Database: CAPLUS
A process for the prepn. of the enol lactone of (-)-1R-cis-2,2-dimethyl-3-(-2'-oxopropyl)cyclopropanecarboxylic acid from (-)-1R-cis-2,2-Dimethyl-3-(2'-oxopropyl)cyclopropanecarboxylic acid (i.e., the C9 keto acid) comprises: adding 3-5 mol percent of p-toluenesulfonic acid (PTSA) to the C9-keto acid; cooling the above to 0-10°; adding a 1.0-1.5 M excess of an acid anhydride; stirring the above mixt. at 0-100°C; until the reaction is complete adding a predetd. amt. of an alkali or an alk. metal acetate (e.g., sodium acetate) to neutralize the PTSA; distg. the acid and the acid anhydride; extg....
~0
7. Preparation of deltamethrin from biocartol
Quick View
By Sharma, Sudhir Kumar; Shrivastava, Dhananjay; Rajaram, Janakiram; Khullar, Alok; Pandey, Inder Kumar; Sharma, Rajeev Kumar; Madhusoodanan, Sundaresan
From Indian (2003), IN 189300 B 20030208. | Language: English, Database: CAPLUS
A process for the prepn. of deltamethrin (I) was disclosed. For example, thionyl chloride mediated condensation of acid II/m-phenoxybenzaldehyde/NaCN afforded deltamethrin in one step.
~0
8. Improved process for the preparation of hemiacetal 4-hydroxy-6,6-dimethyl-3-oxabicyclo[3.1.0]hexan-2-one by ozonolysis ad reduction of the enol lactone of (-)-1R-cis-2,2-dimethyl-3-(2-oxopropyl)cyclopropanecarboxylic acid
Quick View
By Khullar, Alok; Pandey, Inder Kumar; Sharma, Rajeev Kumar; Sharma, Sudhir Kumar; Shrivastava, Dhananjay; Rajaram, Jankiram; Madhusoodanan, Sundaresan
From Indian (2003), IN 190384 B 20030726. | Language: English, Database: CAPLUS
This invention relates to a process for the prepn. of title hemiacetal I ozonolysis of enol lactone II followed by reductive quenching, comprising: dissolving II in an org. solvent, subjecting the said soln. to ozonolysis at -10° to -15°, adding the said soln. slowly to an aq., alc. or aq.-alc. soln. of an inorg. reducing agent under stirring, maintaining the temp. of the reaction mass at -5° to +2°, stirring the above soln. until the quenching process is complete, filtering off the inorg. salts, removing the solvent at 40 to 45° and 200-10 mm Hg to obtain the crude product consisting primaril...
~0
9. Preparation of deltamethrin
Quick View
By Shrivastava, Dhananjay; Rajaram, Jankiram; Madhusoodanan, Sundaresan; Khullar, Alok; Pandey, Inder Kumar; Sharma, Rajeev Kumar; Sharma, Sudhir Kumar
From Indian (2003), IN 190839 B 20030823. | Language: English, Database: CAPLUS
(-)-1R-cis-2-2,dimethyl-3-(2'-oxopropyl)cyclopropanecarboxylic acid enol lactone is subjected to ozonolysis and hydrolysis to give the corresponding hemiacetal which is brominated into (-)-1R-cis-2-2,dimethyl-3-(1'-hydroxy-2',2',2'-tribromoethyl)cycloproanecarboxylic acid. This intermediate is converted into the corresponding bromolactone, which upon red. with Zn in acetic acid gives deltamethric acid. Chlorination of deltamethric acid with thionyl chloride results in deltamethric acid chloride, which is reacted with Na cyanide and m-methoxybenzaldehyde to yield crude deltamethrin together w...
~0
10. An improved process for the preparation of (-)-(1R)-cis-2,2-dimethyl-3-(2-oxopropyl) cyclopropanecarboxylic acid from (-)-3-caren-5-one
Quick View
By Khullar, Alok; Pandey, Inder Kumar; Sharma, Rajeev Kumar; Sharma, Sudhir Kumar; Shrivastava, Dhanajay; Rajaram; Madhusoodanan, S.
From Indian (2003), IN 189318 B 20030208. | Language: English, Database: CAPLUS
This invention relates to an improved process for the an improved process for the prepn. of (-)-(R)-cis-2,2-dimethyl-3-(2-oxopropyl)cyclopropane carboxylic acid (I) from (-)-3-caren-5-one (II) comprising: dissolving II in a solvent such as herein described; cooling the soln. to 0 to -12°C; passing the ozonized oxygen through the above soln. at -10° to 12°C until ozonolysis is complete; passing nitrogen through the above soln. to remove trace of dissolved ozone; adding the above soln. slowly under agitation to an aq. soln. of a suitable reducing agent such as herein described at 0° to 5°C; stir...
~0
11. An improved process for the preparation of 1R-cis-2,2-dimethyl-3(2',2'-dibromovinyl)-carboxylic acid (deltamethric acid), from 1R-cis-2,2-dimethyl-3-(1'-hydroxy-2',2',2'-tribromo ethyl)cyclopropanecarboxylic acid (bromoacid) using a single reactor
Quick View
By Madhussodanan, Sundaresan; Khullar, Alok; Pandey, Inder Kumar; Sharma, Rajeev Kumar; Sharma, Sudhir Kumar; Shrivasta, Dhananjay; Rajaram, Janakiram
From Indian (2003), IN 189299 B 20030208. | Language: English, Database: CAPLUS
This invention relates to a process for prepg. Deltamethric acid (I) from Bromoacid II in a single according to the invention comprising: (i) reacting a soln. of II in a water immiscible polar/non-polar solvent with an acidic catalyst and removing water by azeotropic distn. to complete lactonization and to get a soln. of bromolactone III in the solvent; (ii) removing the said acidic catalyst from the above soln. by washing it with an aq. bicarbonate/carbonate soln.; (iii) concg. the resulting soln. to remove residual water azeotropically, followed by partial removal of the solvent to get a sol...
~0
12. An improved process for the preparation of (-)-3-caren-5-one from (+)-3-carene by air/oxygen oxidation
Quick View
By Khullar, Alok; Pandey, Inder Kumar; Sharma, Rajeev Kumar; Sharma, Sudhir Kumar; Shrivastava, Dhananjay; Madhusoodanan, S.; Rajaram
From Indian (2002), IN 188755 B 20021102. | Language: English, Database: CAPLUS
This invention relates to an improved process for the prepn. of (-)-3-caren-5-one (I) from (+)-3-carene (II) by air/oxygen oxidn. comprising: (1) charging II under pos. air/oxygen pressure into the reactor (as shown in figure I), with or without a solvent; (2) increasing the air/oxygen flow to 60-200 LPH per Kg of II; (3) charging the catalyst, MR1R2X1X2 [M = cobalt; R1,R2 = pyridine; X1, X2 = halogen ( esp. Cl, Br)] as herein described at 0.1-15% wt. II; (4) heating the reaction mass to 40-100°C; (5) maintaining the reaction mass at 40-100°C for 6-32 h; (6) cooling the reaction mass to 30°C; ...
~0
13. An improved process for preparing (1R,3S)-2,2-dimethyl-3-[2,2,2-tribromo-1-hydroxyethyl]cyclopropanecarboxylic acid (bromacid)
Quick View
By Khullar, Alok; Pandey, Inder Kumar; Sharma, Rajeev Kumar; Madhusoodanan, S.; Sharma, Sudhir Kumar; Shrivastava, Dhananjay; Rajaram, Janakiram
From Indian (2002), IN 187380 B 20020413. | Language: English, Database: CAPLUS
A process for prepg. the title cyclopropane carboxylic acid I from hemiacetal II was disclosed and comprised prepg. a solvent mixt. by mixing an org. ether and an alc., in a ratio of 10-90:90-10 wt.%, dissolving an alkali/alk. earth metal hydroxide in the solvent mixt. at 25-30°C in a ratio of 1:4-10, adding simultaneously II and bromoform to the soln. at -10 to -5° from two different addn. points, such that the mole ratio of metal hydroxide w.r.t. II varies between 1.0-2.0 mol with the quantity of bromoform w.r.t. II between 1.0-1.25 and the quantity of the org. ether w.r.t. II between 3 and ...
~0
14. Electron impact (EI) mass spectral studies on pyridyl thiohydroximic esters and their carbamates
Quick View Other Sources
By Raza, S. K.; Khullar, A.; Joshi, Uma; Jaiswal, D. K.
From Oriental Journal of Chemistry (1999), 15(3), 421-426. | Language: English, Database: CAPLUS
The electron impact (EI) mass spectral studies on pyridyl thiohydroximic esters showed some interesting fragmentation pathways. The probable mechanism for the formation of some of the salient fragments was confirmed by performing daughter ion expts. The daughter ion spectra of Me and cyclohexyl derivs. exhibited a stepwise loss of OH and RN whereas in Ph deriv. a concerted loss of PhNOH was obsd. to give an ion at m/z 122 from the skeletally rearranged mol. ion. The Me and cyclohexyl derivs. also produced an ion at m/z 154 arising due to Mc Lafferty rearrangement. The carbamates showed sim...
~0
15. Synthesis, characterization and thermal decomposition of carbamoylphosphonates
Quick View Other Sources
By Raza, S. K.; Khullar, A. K.; Agarwal, Seema; Jaiswal, D. K.
From Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1996), 35B(2), 154-6. | Language: English, Database: CAPLUS
Carbamoylphosphonates, e.g., (EtO)2P(O)CONHPh, were synthesized by the direct reaction of isocyanates, e.g., PhNCO, with dialkyl phosphites catalyzed by Na metal. The compds. were characterized from their anal. and spectral data. Their thermal behavior was studied using dynamic TG and off-line pyrolysis gas chromatog.
~0
16. Synthesis and biological evaluation of oxime carbamates
Quick View Other Sources
By Raza, S. K.; Khullar, A.; Jaiswal, D. K.
From Oriental Journal of Chemistry (1994), 10(3), 253-8. | Language: English, Database: CAPLUS
A series of carbamates, e.g., I (R = Me, Ph, C6H11), derived from pyridine aldoximes and thiohydroximic thioesters have been prepd. by their reaction with isocyanates. The quaternized salts of pyridine aldoxime carbamates, e.g., II, have also been synthesized. The compds. synthesized were evaluated for their efficacy as acetylcholinesterase inhibitors. Most of these were found to be good inhibitors, their I50 values ranged between 10-6 - 10-9 M.
Quick View
By Dubey, Pradip Kumar; Khullar, Alok; Suckley, Daniel; Naiyawat, Thipa; Noiphom, Nok; Kunwong, Dapawan; Samuthsen, Patcharin; Chamongkolpradit, Worakan; Noghan, Suphansa; Changsarn, Nalintip
From Indian Pat. Appl. (2019), IN 201711036901 A 20190621. | Language: English, Database: CAPLUS
The invention relates to a glycidyl amine epoxy resin obtained by reaction of a diamine with epichlorohydrin, wherein diamine has at least two amine group with at least one labile hydrogen on each nitrogen; at least one nitrogen atom is directly attached to an arom. ring on one side; at least 1 amine group is hindered amine either due to hindered arom. ring having at least one substitution on ring at ortho position to carbon which is directly attached to amine group or due to branched aliph. carbon directly attached to amine group; wherein the diamine is AMES neg. A curable coating system com...
~0
2. Glycidyl amine epoxy resins based on non-carcinogenic AMES negative amines
Quick View
By Dubey, Pradip Kumar; Khullar, Alok; Suckley, Daniel; Naiyawat, Thipa; Noiphom, Nok; Kunwong, Dapawan; Samuthsen, Patcharin; Chamongkolpradit, Worakan; Noghan, Suphansa; Changsarn, Nalintip
From PCT Int. Appl. (2019), WO 2019077523 A1 20190425. | Language: English, Database: CAPLUS
The invention relates to a glycidyl amine epoxy resin obtained by reaction of a diamine with epichlorohydrin, wherein diamine has at least two amine group with at least one labile hydrogen on each nitrogen; at least one nitrogen atom is directly attached to an arom. ring on one side; at least 1 amine group is hindered amine either due to hindered arom. ring having at least one substitution on ring at ortho position to carbon which is directly attached to amine group or due to branched aliph. carbon directly attached to amine group; wherein the diamine is AMES neg. A curable coating system com...
~0
3. Energy efficient manufacturing process for preparing N,O-triglycidyl aminophenols useful for synthesis of epoxy resins
Quick View
By Dubey Pradip, Kumar; Khullar, Alok; Nayawat, Thipa; Visatsingh, Kamonsun; Samuthsen, Patcharin; Samant, Prashant
From PCT Int. Appl. (2015), WO 2015174936 A1 20151119. | Language: English, Database: CAPLUS
The invention relates to an improved process for making monomeric triglycidyl compds., wherein the triglycidyl compds. include N, O-triglycidyl compds. contg. at least one primary arom. amine and one phenolic functional group attached to the same or a different arom. ring. The methods of the present invention result in the prodn. of N, O-triglycidyl compds., such as those of formula I and II; wherein: R1 and R2 are each independently selected from the group consisting of hydrogen, halogen, or Ci-Q alkyl; R and R' are each independently selected from the group consisting of hydrogen, GVQ alkyl...
~0
4. Improved manufacturing process for dihydroxydiphenylmethane with high selectivity for 2,4'-dihydroxydiphenylmethane by reacting phenol and formaldehyde in the presence of polyprotic inorganic acid catalyst
Quick View
By Dubey Pradip, Kumar; Khullar, Alok; Naiyawat, Thipa; Visatsingh, Kamonsun; Samuthsen, Patcharin; Mathure, Pankaj
From PCT Int. Appl. (2015), WO 2015041614 A1 20150326. | Language: English, Database: CAPLUS
The invention relates to a process for manufg. dihydroxydiphenylmethane, comprising reacting phenol with formaldehyde and a polyprotic inorg. acid catalyst in a heterogeneous phase at a temp. of 85 - 100° and recovering the inorg. acid catalyst. The invention also relates to a compn., comprising at least 88 mol% of dihydroxydiphenylmethanes, wherein at least 58 mol% of dihydroxydiphenylmethane is 2,2'- bis(hydroxyphenyl)methane and 2,4'-bis(hydroxyphenyl)methane.
~1
5. An improved process for preparing deltamethrin, (S)-α-cyano-3-phenoxybenzyl-(1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane carboxylate from δ-3-carene
Quick View
By Khullar, Alok; Kumar, Inder; Sharma, Rajeev Kumar; Sharma, Sudhir Kumar; Srivastava, Dhananjay; Ranjan; Madhusoodanan, S.
From Indian Pat. Appl. (2014), IN 2002DE00766 A 20140207. | Language: English, Database: CAPLUS
This invention relates to a process for prepg. deltamethrin (I) comprising: prepg. δ-3-caren-5-one (II) by oxidizing δ-3-carene (III) in the presence of air/oxygen and cobalt pyridinium halide catalyst and subsequently isolating II through continuous distn. and fractionation;. Subjecting the said II in a polar/non-polar solvent to ozonolysis followed by quenching with aq. sodium sulfite soln. to obtain crude C9-Ketoacid IV in a known manner, purifying the said IV;. Stirring the said purified IV with an acid anhydride and para-toluenesulfonic acid catalyst until lactonization is complete;. I...
~0
6. Process for the preparation of the enol lactone of (-)-1R-2,2-dimethyl-3-(2-oxopropyl)cyclopropanecarboxylic acid from (-)-1R-cis-2,2-dimethyl-3-(2'-oxopropyl)cyclopropanecarboxylic acid
Quick View
By Khullar, Alok; Pandey, Inder Kumar; Sharma, Rajeev Kumar; Sharma, Sudhir Kumar; Shrivastava, Dhananjay; Rajaram; Madhusoodanan, S.
From Indian (2002), IN 188414 B 20020921. | Language: English, Database: CAPLUS
A process for the prepn. of the enol lactone of (-)-1R-cis-2,2-dimethyl-3-(-2'-oxopropyl)cyclopropanecarboxylic acid from (-)-1R-cis-2,2-Dimethyl-3-(2'-oxopropyl)cyclopropanecarboxylic acid (i.e., the C9 keto acid) comprises: adding 3-5 mol percent of p-toluenesulfonic acid (PTSA) to the C9-keto acid; cooling the above to 0-10°; adding a 1.0-1.5 M excess of an acid anhydride; stirring the above mixt. at 0-100°C; until the reaction is complete adding a predetd. amt. of an alkali or an alk. metal acetate (e.g., sodium acetate) to neutralize the PTSA; distg. the acid and the acid anhydride; extg....
~0
7. Preparation of deltamethrin from biocartol
Quick View
By Sharma, Sudhir Kumar; Shrivastava, Dhananjay; Rajaram, Janakiram; Khullar, Alok; Pandey, Inder Kumar; Sharma, Rajeev Kumar; Madhusoodanan, Sundaresan
From Indian (2003), IN 189300 B 20030208. | Language: English, Database: CAPLUS
A process for the prepn. of deltamethrin (I) was disclosed. For example, thionyl chloride mediated condensation of acid II/m-phenoxybenzaldehyde/NaCN afforded deltamethrin in one step.
~0
8. Improved process for the preparation of hemiacetal 4-hydroxy-6,6-dimethyl-3-oxabicyclo[3.1.0]hexan-2-one by ozonolysis ad reduction of the enol lactone of (-)-1R-cis-2,2-dimethyl-3-(2-oxopropyl)cyclopropanecarboxylic acid
Quick View
By Khullar, Alok; Pandey, Inder Kumar; Sharma, Rajeev Kumar; Sharma, Sudhir Kumar; Shrivastava, Dhananjay; Rajaram, Jankiram; Madhusoodanan, Sundaresan
From Indian (2003), IN 190384 B 20030726. | Language: English, Database: CAPLUS
This invention relates to a process for the prepn. of title hemiacetal I ozonolysis of enol lactone II followed by reductive quenching, comprising: dissolving II in an org. solvent, subjecting the said soln. to ozonolysis at -10° to -15°, adding the said soln. slowly to an aq., alc. or aq.-alc. soln. of an inorg. reducing agent under stirring, maintaining the temp. of the reaction mass at -5° to +2°, stirring the above soln. until the quenching process is complete, filtering off the inorg. salts, removing the solvent at 40 to 45° and 200-10 mm Hg to obtain the crude product consisting primaril...
~0
9. Preparation of deltamethrin
Quick View
By Shrivastava, Dhananjay; Rajaram, Jankiram; Madhusoodanan, Sundaresan; Khullar, Alok; Pandey, Inder Kumar; Sharma, Rajeev Kumar; Sharma, Sudhir Kumar
From Indian (2003), IN 190839 B 20030823. | Language: English, Database: CAPLUS
(-)-1R-cis-2-2,dimethyl-3-(2'-oxopropyl)cyclopropanecarboxylic acid enol lactone is subjected to ozonolysis and hydrolysis to give the corresponding hemiacetal which is brominated into (-)-1R-cis-2-2,dimethyl-3-(1'-hydroxy-2',2',2'-tribromoethyl)cycloproanecarboxylic acid. This intermediate is converted into the corresponding bromolactone, which upon red. with Zn in acetic acid gives deltamethric acid. Chlorination of deltamethric acid with thionyl chloride results in deltamethric acid chloride, which is reacted with Na cyanide and m-methoxybenzaldehyde to yield crude deltamethrin together w...
~0
10. An improved process for the preparation of (-)-(1R)-cis-2,2-dimethyl-3-(2-oxopropyl) cyclopropanecarboxylic acid from (-)-3-caren-5-one
Quick View
By Khullar, Alok; Pandey, Inder Kumar; Sharma, Rajeev Kumar; Sharma, Sudhir Kumar; Shrivastava, Dhanajay; Rajaram; Madhusoodanan, S.
From Indian (2003), IN 189318 B 20030208. | Language: English, Database: CAPLUS
This invention relates to an improved process for the an improved process for the prepn. of (-)-(R)-cis-2,2-dimethyl-3-(2-oxopropyl)cyclopropane carboxylic acid (I) from (-)-3-caren-5-one (II) comprising: dissolving II in a solvent such as herein described; cooling the soln. to 0 to -12°C; passing the ozonized oxygen through the above soln. at -10° to 12°C until ozonolysis is complete; passing nitrogen through the above soln. to remove trace of dissolved ozone; adding the above soln. slowly under agitation to an aq. soln. of a suitable reducing agent such as herein described at 0° to 5°C; stir...
~0
11. An improved process for the preparation of 1R-cis-2,2-dimethyl-3(2',2'-dibromovinyl)-carboxylic acid (deltamethric acid), from 1R-cis-2,2-dimethyl-3-(1'-hydroxy-2',2',2'-tribromo ethyl)cyclopropanecarboxylic acid (bromoacid) using a single reactor
Quick View
By Madhussodanan, Sundaresan; Khullar, Alok; Pandey, Inder Kumar; Sharma, Rajeev Kumar; Sharma, Sudhir Kumar; Shrivasta, Dhananjay; Rajaram, Janakiram
From Indian (2003), IN 189299 B 20030208. | Language: English, Database: CAPLUS
This invention relates to a process for prepg. Deltamethric acid (I) from Bromoacid II in a single according to the invention comprising: (i) reacting a soln. of II in a water immiscible polar/non-polar solvent with an acidic catalyst and removing water by azeotropic distn. to complete lactonization and to get a soln. of bromolactone III in the solvent; (ii) removing the said acidic catalyst from the above soln. by washing it with an aq. bicarbonate/carbonate soln.; (iii) concg. the resulting soln. to remove residual water azeotropically, followed by partial removal of the solvent to get a sol...
~0
12. An improved process for the preparation of (-)-3-caren-5-one from (+)-3-carene by air/oxygen oxidation
Quick View
By Khullar, Alok; Pandey, Inder Kumar; Sharma, Rajeev Kumar; Sharma, Sudhir Kumar; Shrivastava, Dhananjay; Madhusoodanan, S.; Rajaram
From Indian (2002), IN 188755 B 20021102. | Language: English, Database: CAPLUS
This invention relates to an improved process for the prepn. of (-)-3-caren-5-one (I) from (+)-3-carene (II) by air/oxygen oxidn. comprising: (1) charging II under pos. air/oxygen pressure into the reactor (as shown in figure I), with or without a solvent; (2) increasing the air/oxygen flow to 60-200 LPH per Kg of II; (3) charging the catalyst, MR1R2X1X2 [M = cobalt; R1,R2 = pyridine; X1, X2 = halogen ( esp. Cl, Br)] as herein described at 0.1-15% wt. II; (4) heating the reaction mass to 40-100°C; (5) maintaining the reaction mass at 40-100°C for 6-32 h; (6) cooling the reaction mass to 30°C; ...
~0
13. An improved process for preparing (1R,3S)-2,2-dimethyl-3-[2,2,2-tribromo-1-hydroxyethyl]cyclopropanecarboxylic acid (bromacid)
Quick View
By Khullar, Alok; Pandey, Inder Kumar; Sharma, Rajeev Kumar; Madhusoodanan, S.; Sharma, Sudhir Kumar; Shrivastava, Dhananjay; Rajaram, Janakiram
From Indian (2002), IN 187380 B 20020413. | Language: English, Database: CAPLUS
A process for prepg. the title cyclopropane carboxylic acid I from hemiacetal II was disclosed and comprised prepg. a solvent mixt. by mixing an org. ether and an alc., in a ratio of 10-90:90-10 wt.%, dissolving an alkali/alk. earth metal hydroxide in the solvent mixt. at 25-30°C in a ratio of 1:4-10, adding simultaneously II and bromoform to the soln. at -10 to -5° from two different addn. points, such that the mole ratio of metal hydroxide w.r.t. II varies between 1.0-2.0 mol with the quantity of bromoform w.r.t. II between 1.0-1.25 and the quantity of the org. ether w.r.t. II between 3 and ...
~0
14. Electron impact (EI) mass spectral studies on pyridyl thiohydroximic esters and their carbamates
Quick View Other Sources
By Raza, S. K.; Khullar, A.; Joshi, Uma; Jaiswal, D. K.
From Oriental Journal of Chemistry (1999), 15(3), 421-426. | Language: English, Database: CAPLUS
The electron impact (EI) mass spectral studies on pyridyl thiohydroximic esters showed some interesting fragmentation pathways. The probable mechanism for the formation of some of the salient fragments was confirmed by performing daughter ion expts. The daughter ion spectra of Me and cyclohexyl derivs. exhibited a stepwise loss of OH and RN whereas in Ph deriv. a concerted loss of PhNOH was obsd. to give an ion at m/z 122 from the skeletally rearranged mol. ion. The Me and cyclohexyl derivs. also produced an ion at m/z 154 arising due to Mc Lafferty rearrangement. The carbamates showed sim...
~0
15. Synthesis, characterization and thermal decomposition of carbamoylphosphonates
Quick View Other Sources
By Raza, S. K.; Khullar, A. K.; Agarwal, Seema; Jaiswal, D. K.
From Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1996), 35B(2), 154-6. | Language: English, Database: CAPLUS
Carbamoylphosphonates, e.g., (EtO)2P(O)CONHPh, were synthesized by the direct reaction of isocyanates, e.g., PhNCO, with dialkyl phosphites catalyzed by Na metal. The compds. were characterized from their anal. and spectral data. Their thermal behavior was studied using dynamic TG and off-line pyrolysis gas chromatog.
~0
16. Synthesis and biological evaluation of oxime carbamates
Quick View Other Sources
By Raza, S. K.; Khullar, A.; Jaiswal, D. K.
From Oriental Journal of Chemistry (1994), 10(3), 253-8. | Language: English, Database: CAPLUS
A series of carbamates, e.g., I (R = Me, Ph, C6H11), derived from pyridine aldoximes and thiohydroximic thioesters have been prepd. by their reaction with isocyanates. The quaternized salts of pyridine aldoxime carbamates, e.g., II, have also been synthesized. The compds. synthesized were evaluated for their efficacy as acetylcholinesterase inhibitors. Most of these were found to be good inhibitors, their I50 values ranged between 10-6 - 10-9 M.