The Combined Use of Bacillus thuringiensis Insecticide and Double-Stranded RNA for Insect Control

Status: Open
Deadline: Ongoing
Award: $12,500 for each accepted prior art citation

The Seeker is looking for any non-patent literature, presentations, posters, proceedings, literature, proposals, reports, patents or patent applications, etc. publicly disclosed prior to April 9, 2004 to challenge the novelty of specific concepts and methods in the claims of these patents:

US 9,238,822 B2     US 8,946,510 B2     EP 1 818 405 B1     EP 1 732 379 B1

The information of interest will most likely be found in publicly disclosed, non-patent literature such as: presentations, posters, public lectures, oral proceedings, conference proceedings, literature, scientific journals, research proposals or reports, university trials, citations, laboratory manuals, or publicly available thesis.

Information can be from primary or secondary sources and in English language or non-English with relevant passages translated into English.

The expected deliverable is a reference publicly disclosed prior to April 9, 2004 providing the information or evidence listed.

Information of greatest interest will describe control of Western corn rootworm (WCR) by use of a combination of a Bacillus thuringiensis (Bt) insecticide and a double-stranded RNA that inhibits an essential gene of WCR (for example, genes involved in normal growth, reproduction or metabolism).

Western corn rootworm

Information of greatest interest:

References will describe control of Western corn rootworm (WCR) by use of a combination of a Bacillus thuringiensis (Bt) insecticide and a double-stranded (ds)RNA that inhibits an essential gene of WCR. Examples include any combination of:

  • A Bt insecticidal agent expressed in a transgenic plant (any species), sprayed on a plant, or as part an artificial diet,
AND
  • A dsRNA that targets an essential gene in Western corn rootworm expressed in a transgenic plant (any species), sprayed on a plant, or as part of an artificial diet.

Relevant citations of greatest interest will relate to Western corn rootworm (Diabrotica virgifera). Information for other Diabrotica rootworm species or other coleopteran species (beetles) may also be of interest for partial award, but the Bt toxin and dsRNA must control the same Diabrotica/coleopteran pest.


Information of Interest for Partial Award:

References describing the use of any combination of inhibitory RNA molecules with another pesticide to control the same target insect species. Any inhibitory RNA molecule is of interest.

Essential genes are generally genes involved in normal growth, reproduction or metabolism.

References of greatest interest will describe the combined impact of dsRNA with another pesticide on coleopteran insects (beetles) and, especially, for Western corn rootworm (Diabrotica virgifera).


Key concepts: RNA interference, RNAi, double-stranded RNA, dsRNA, antisense RNA; Bacillus thuringiensis (BT) insecticide; control of Western corn rootworm, Diabrotica virgifera, Diabrotica spp.

Trade names for products containing Bacillus thuringiensis or Bt-based insecticidal agents include Acrobe, Agree, Bactospeine, Berliner, Biobit, Condor, Certan, Cutlass, Dipel, Foil, Full-Bac, Javelin, Leptox, M-Peril, M-Trak, MVP, Novabac, Novodor, Teknar, Thuricide, Victory, and Xentari.

Trade names for transgenic plants expressing insecticidal Bt proteins include:
Herculex, Agrisure, Yieldgard, Genuity.

Some commercial transgenic plant events expressing insecticidal Bt proteins include:

  • 89034
  • 88107
  • MON810
  • MON863
  • TC1507
  • DAS-59122-7
  • Bt11
  • MIR162
  • MIR604

The following patents and non-patent references are excluded from the Challenge:
Patent and non-patent references in:

US 9,238,822 B2 on pages 1 - 4:
US3937813
US4948734
US5107065
US5231020
US5283184
US5629469
US5759829
US5858353
US5866784
US5914318
US6326193
US6433247
US6506559
US6573099
US6586365
US6703491
US6753139
US7030290
US7109393
US7314974
US7348410
US7358069
US7612194
US7618814
US7741118
US7741531
US7754697
US7812219
US7943819
US7999148
US8404927
US20010016953
US20020048814
US20020129400
US20020137710
US20030018993
US20030054391
US20030061626
US20030150017
US20030154508
US20030175965
US20040029283
US20040053876
US20040123343
US20040133943
US20040220199
US20040241651
US20050095199
US20060021087
US20060035344
US20060174380
US20060200878
US20060272049
US20070011775
US20070050860
US20070061918
US20070124836
US20090307803
US20100192265
US20110154545
US20120137387
US20120164205
US20140194306
AR047897A1
CA2094658A1
CA2582550A1
CN1307641A
CN1412311A
CN88102497A
EP0289479A2
EP1644480A2
RU2157644C1
RU2198221C2
WO1994001550A1
WO1998005770A2
WO1999005315A2
WO1999031253A2
WO1999036520A1
WO1999049029A1
WO1999053050A1
WO1999061631A1
WO2000001846A2
WO2000066742A2
WO2001009301A2
WO2001034815A1
WO2001037654A2
WO2001048183A2
WO2001070929A2
WO2001077384A2
WO2001088121A1
WO2002006940A2
WO2002013609A1
WO2002033405A1
WO2002046432A2
WO2002077183A2
WO2003004644A1
WO2003018810A2
WO2003031577A2
WO2003076619A1
WO2004013169A1
WO2004022771A2
WO2004073390A1
WO2004108899A2
WO2005019408A2
WO2005049841A1
WO2005071091A1
WO2005082932A2
WO2005110068A8
WO2006045590A3
WO2006045591A3
WO2006046148A3
WO2006070227A3
WO2006129204A3
WO2007074405A2
WO2007083193A2
WO2007095496A3
WO2009021288A1
US 8,946,510 B2 on pages 1 - 4:
US3937813
US4948734
US5107065
US5231020
US5283184
US5629469
US5759829
US5858353
US5866784
US5914318
US6326193
US6433247
US6506559
US6573099
US6586365
US6703491
US6753139
US7030290
US7109393
US7314974
US7348410
US7358069
US7612194
US7618814
US7741118
US7741531
US7754697
US7812219
US7999148
US8404927
US20010016953
US20020048814
US20020129400
US20020137710
US20030018993
US20030054391
US20030061626
US20030150017
US20030154508
US20030175965
US20040029283
US20040053876
US20040123343
US20040133943
US20040220199
US20040241651
US20050095199
US20060021087
US20060035344
US20060174380
US20060200878
US20060272049
US20070011775
US20070050860
US20070061918
US20070124836
US20100192265
US20110154545
US20120137387
US20120164205
US20140194306
AR047897A1
CA2094658A1
CA2582550A1
CN1307641A
CN1412311A
CN88102497A
EP0289479A2
EP1644480A2
RU2157644C1
RU2198221C2
WO1994001550A1
WO1998005770A2
WO1999005315A2
WO1999031253A2
WO1999036520A1
WO1999049029A1
WO1999053050A1
WO1999061631A1
WO2000001846A2
WO2000066742A2
WO2001009301A2
WO2001034815A1
WO2001037654A2
WO2001048183A2
WO2001070929A2
WO2001077384A2
WO2001088121A1
WO2002006940A2
WO2002013609A1
WO2002033405A1
WO2002046432A2
WO2002077183A2
WO2003004644A1
WO2003018810A2
WO2003031577A2
WO2003076619A1
WO2004013169A1
WO2004022771A2
WO2004073390A1
WO2004108899A2
WO2005019408A2
WO2005049841A1
WO2005071091A1
WO2005082932A2
WO2005110068A8
WO2006045590A3
WO2006045591A3
WO2006046148A3
WO2006070227A3
WO2006129204A3
WO2007074405A2
WO2007083193A3
WO2007095496A2
WO2009021288A1
EP 1 818 405 B1 on page 1:
US6429360
US6551962
US6642030
US20030154508
WO1999028477A1
WO2001091559A2
WO2003004644A1
WO2003018810A2
WO2005049841A1
WO2005107383A2
EP 1 732 379 B1 on pages 1 - 2:
WOA0134815
WOA0137654
WOA03004644
USB16703491
US20030150017A
US5107065A
US5759829A
US5283184A
US5231020A
WO9953050A
WO9949029A
US20030175965A
US20030061626A
US465800A
US6506559B
US6326193B
WO9401550A
WO9805770A
US20020048814A
US20030018993A
US6506599B
US6551962B
US5876739A
US5918413A
US5891246A
US5554445A
US5389399A
US5107787A
US5080925A
US4759945A
US4465017A
US5939356A
US5882713A
US5849320A
US5834447A
US5791084A
US5661103A
US5622003A
US5580544A
US5328942A
US5300127A
US4735015A
US4634587A
US4383391A
US4372080A
US4339456A
US4272417A
US4245432A
US205189A
WO9732016A
US5593874A
US5698425A
US5712135A
US5789214A
US5804693A
EP0127328A
EP0284044A
EP03215447A
US4876197A
US4880734A
EP0164556A
US20040029283A
US5837848A
US6489542A
US4959317A
US5527695A
US5550318A
US5633435A
US5780708A
US6118047A
US4536475A
US4693977A
US4886937A
US5501967A
EP0122791A
EP0120516A
US5015580A
US5538880A
US6153812A
US6160208A
US6288312B
US6399861B
US5159135A
US5824877A
US5591616A
US6384301B
US20518902A
US6642030B
US64313604P
WO60560842A
WO60565632A
WO60579062A
WO60603421A
WO60617261A

WO99/28477, Commonwealth Scientific and Industrial Research Organisation (Akhurst et al.) 10 June 1999

WO01/37654, DNA Plant Technology Corp. (Tobias et al.) 31 May 2001

WO01/91559, Steyn 06 December 2001

WO05/107383, Monsanto Technology LLC (Donovan et al.) 17 November 2005

US 6,429,360, Syngenta Investment Corp. (Estruch et al.) 06 August 2002

US 6,551,962, Monsanto Technology LLC (Pershing et al.) 22 April 2003

US 6,642,030, Monsanto Technology LLC (English et al.) 04 November 2003

US 6,703,491, Exelixis, Inc. (Homburger et al.) 09 March 2004

US 2003/0236195, Mycogen Corp. (Feitelson et al.) 25 December 2003

Note: All related patent applications and patents, including foreign equivalents, of any listed patent documents are also excluded.


A prior art citation is any presentation, oral proceeding, grant proposal, lecture notes, thesis (PhD or Masters), conference proceeding, conference poster, foreign language citation, government report or other dissemination of information or technology that publicly discloses the specific concepts related to the search prior to the date indicated.

Please be VERY specific about how your submission meets the request criteria, and include a copy of the actual citation, not just an excerpt.

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Citation Details


Indicate the page number(s), section number or clearly highlight the relevant information on the combination of RNA and another pesticide.

In your own words, describe the specific combination of an RNA and another pesticide mentioned in the citation. If you do not provide this information, your submission will not be reviewed. Use your own words, and do not cut and paste text from the citation or challenge description. Please also provide any other information that describes in detail how the citation meets the requirements.:

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