A Novel Regulator of Cellular Senescence

Provided herein are methods for regulating whether a cell undergoes apoptosis or senescence, comprising modulating the level of expression an/or activity of SENEX in the cell, wherein increasing the expression and/or activity of SENEX relative to normal endogenous levels induces cellular senescence and decreasing the expression and/or activity of SENEX relative to normal endogenous levels induces apoptosis. Methods for the diagnosis and treatment of senescence-associated and apoptosis-associated disorders are also provided.

Patents:
WO 2,010,148,447

Inventor(s): GAMBLE JENNIFER [AU]; VADAS MATHEW [AU]; HAHN CHRIS [AU]; COLEMAN PAUL [AU]

Type of Offer: Sale



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