Imaging Dyes and Use Thereof

Use of a metal complex having the formula: [M(L1)a(L2)b(L3)c]-Xd-Pepe wherein M is a metal selected from osmium, ruthenium, rhodium, rhenium or copper; L1, L2, L are bidentate or tridentate heterocyclic ligands containing O and/or N and may be the same or different; a, b, c are integers between 0 to 3 and may be the same or different and wherein the sum of a+b+c is 2 or 3; X is a functional group for directly or indirectly covalently binding to Pep wherein the functional group for directly covalently binding to Pep is selected from: amine, carboxylic acid, thiol or azide reactive functionalities; Pep is a peptide; d and e are integers between 1 and 3 and are the same and wherein the integers for d and e are equal to or less than the sum of a+b+c; and wherein there is optionally a linker between X and Pep for imaging of a cell or cell derived biological sample.

Attached files:


Patents:
WO 2,009,078,000

Inventor(s): GOSGRAVE LYNDA [IE]; KEYES TIA E [IE]; FORSTER ROBERT J [IE]; PELLEGRIN YANN [IE]; DEVOCELLE MARC [IE]; MORAN NIAMH [IE]; KENNY

Type of Offer: Sale



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