Modified Cipa Gene from Clostridium Thermocellum for Enhanced Genetic Stability
Bacteria consume a variety of biomass-derived substrates and produce ethanol. The scaffoldin gene cipA from Clostridium thermocellum is modified to generate a mutated gene with enhanced genetic stability. This mutated cipA gene can be introduced into a heterologous host, such as Thermoanaerobacterium saccharolyticum. Other cellulosome components may be introduced into the host to build a full-sized cellulosome in T. saccharolyticum. Manipulation of the scaffoldin genes provides a new approach for enhancing ethanol production by biomass-fermenting microorganisms.
Patents:WO 2,010,124,000
Inventor(s):
CURRIE DEVIN HEDLEY [US]; MCBRIDE JOHN [US]; GUSS ADAM [US]
Type of Offer:
Licensing
« More Genetics Patents« More Biomass Patents