Phospholipid Micellar and Liposomal Compositions and Uses Thereof

The invention generally relates to compositions and methods for the reduction or neutralization of toxins associated with a bacterial, mycobacterial, fungal, viral, or protozoal agent. More particularly, the invention is directed to sterically stabilized phospholipid micellar and liposomal compositions, which interact with the toxins to decrease or neutralize their toxicity. Additionally, the invention includes the use of sterically stabilized phosholipid micellar compositions comprising one or more water-insoluble antibiotic, antifungal, antiviral, antiprotozoal, or anti-inflammatory agent(s), wherein the micellar or liposomal composition inhibits the formation of aggregates. The invention further includes the use of sterically stabilized micelle and liposomal compositions to deliver compounds to the site of action, and in some cases targets the compound to the site of action, for the treatment of inflammation and infection. The invention includes the use of combinations of such micellar and liposomal compositions to improve the effectiveness of treatment.

Patents:
WO 2,010,045,479

Inventor(s): ONYUKSEL HAYAT [US]; RUBINSTEIN ISRAEL [US]

Type of Offer: Licensing



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