Prevention of Flap Necrosis in Plastic Surgery

PROBLEM TO BE SOLVED: To provide a method for resolving or preventing vasoconstriction and preventing depletion of blood flow or restoring blood flow in a pedicle flap or any other microsurgery. ; SOLUTION: The method for preventing necrosis in a pedicle flap or in any microvascular surgery comprises topically applying to pedicle or other source of blood supply, a therapeutically effective amount of a vasodilator composition containing an NO or NO donor or a prodrug that causes formation of nitrosothiol in tissue, optionally in combination with lidocaine. ; COPYRIGHT: (C)2010,JPO&INPIT

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Patents:
JP 2,010,047,619

Inventor(s): STAMLER JONATHAN S; ZENN MICHAEL R; TOONE ERIC J

Type of Offer: Licensing



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