p16 KO Lines for Drug Discovery

p16 tumor suppressor gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Bachman et al., 2003 Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for novel molecules that target the DNA methylation or the p16 pathway in human cancer cells or to confirm the specificity of drugs discovered through other approaches. Such drugs can potentially be used as chemotherapeutic or chemopreventive agents for specific cancers.

Inventor(s): Vogelstein, Bert

Type of Offer: Licensing



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