Promoters for Neural Regeneration

Background Injury to the human central nervous system (CNS) is usually difficult to treat because of the limited regeneration capabilities of the neurons. Evidence suggests that the lack of CNS regeneration is due to the presence of inhibitory factors in the CNS environment. Myelin-associated Glycoprotein (MAG) is a major inhibitory molecule associated with myelin that actively restricts axon regeneration after injures to the CNS. Technology This invention describes a functional assay that determines the signaling of myelin-associated inhibitory factors and also identifies a new receptor of MAG that mediates MAG signaling in CNS neurons. Antibodies to this receptor blocks the action of MAG. In addition, the inventors have identified a target that mediates the inhibitory signaling downstream of the receptor. Interfering this downstream target also blocks effects of MAG. Description (Set) Proposed Use (Set) The identified receptor and the downstream signaling molecule could be targets for therapeutic interventions designed to promote axon regeneration after injury, including spinal cord injury and brain trauma. These proteins could also be targets of therapeutic interventions designed to limit undesired axonal sprouting after certain brain insults, such as epilepsy.

Inventor(s): Ming, Guo-li

Type of Offer: Licensing



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