HOXB7 as a Potential Prognostic Marker and Therapeutic Target in Cancer

Scientists at The Johns Hopkins University have determined that HOXB7, a member of homeobox superfamily of transcription factors, regulates the expression of EGFR/ER2 and ER?and functionally orchestrates their function in breast cancer cells. In addition, the amelioration of HOXB7 expression using siRNA in multiple breast cancer cell lines results in significant inhibition of tumor growth. This discovery suggests that HOXB7 could be used as a breast cancer prognostic marker and a therapeutic target. Description (Set) Proposed Use (Set) Commercial products can be developed to examine the expression of HOXB7 in human breast cancer tissue for diagnostic and prognostic purposes. Small molecule drugs or biological products that target HOXB7 will significantly improve the therapeutics of breast cancer.

Inventor(s): Sukumar, Saraswati V.

Type of Offer: Licensing



« More Medical Patents

---