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Diagnostic Technologies for Sale or License

The following are Diagnostic technologies offered for sale or license. Viewing technologies for sale is a free service of IdeaConnection.com, as is connecting with the seller if a technology interests you. Click on a heading below for more information.

Diagnostics involves the identifying of the nature of anything by any analytical method, such as the process of elimination. Diagnostics involve testing, methods and likelihood ratios. Fields commonly involved in diagnostics are medicine, engineering, computer programming and science. Post your diagnostic technology for sale or license here.

COMPOSITIONS AND METHODS FOR DETECTING PLECTIN-1 AS A BIOMARKER FOR CANCER

The present invention provides compositions and methods useful for diagnostic and imaging techniques for detecting and localizing the biomarker Plectin-1. The present invention provides multimeric pep..

IN VIVO ISOTOPIC LABELING METHOD FOR QUANTITATIVE GLYCOMICS

The present invention relates to a method of isotopically labeling glycans and in facilitating high throughput quantitative/comparative analysis of glycomic compositions of biological cells. The metho..

DIAGNOSTIC ASSAY FOR TRYPANOSOMA CRUZI INFECTION

A sensitive, multicomponent diagnostic test for infection with T. cruzi, the causative agent of Chagas disease, including methods of making and methods of use. Also provided is a method for screening ..

PROTEIN MARKERS IDENTIFICATION FOR GASTRIC CANCER DIAGNOSIS

Methods for detecting cancer as well as methods of diagnosis of cancer by detecting proteins secreted into biological fluids are disclosed The invention was first applied to detecting proteins secrete..

METHODS OF SCREENING FOR RISK OF PROLIFERATIVE DISEASE AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISEASE

A method of screening a subject for a proliferative disease risk factor comprises detecting the presence or absence of upregulation of the CLN3 gene in the subject. The upregulation of the CLN3 gene i..

METHODS OF IDENTIFYING INFECTIOUS DISEASE AND ASSAYS FOR IDENTIFYING INFECTIOUS DISEASE

Methods of identifying infectious disease infection prior to presentation of symptoms, assays for identifying genomic markers of infectious disease, and methods for diagnosing the underlying etiology ..

DIAGNOSTIC AND TREATMENT FOR CHRONIC AND ACUTE PHASE MYELOID LEUKEMIA

Disclosed are methods of predicting responsiveness of a cancer cell to a tyrosine kinase inhibitor, and methods of predicting the risk of progression of a cancer cell to a more aggressive form. Also p..

SYSTEMS AND METHODS FOR GENERATING AN OSTEOARTHRITIS PROGRESSION PREDICTOR AND SYSTEMS AND METHODS FOR USING THE PREDICTOR

Example systems and methods of generating an indicator of osteoarthritis (OA) progression are described. Fractal dimension curves are generated for horizontal and vertical trabecular components associ..

METHODS FOR DETECTING OR MONITORING CANCER USING LPC AS A MARKER

A method of detecting a cancer, such as ovarian cancer, in a test subject including (a) determining the amount of a lysophosphatidyl choline in a sample of a bodily fluid taken from the test subject, ..

Method of Predicting Non-Response to First Line Chemotherapy

The invention provides a method for determining a prognosis of colorectal cancer in a colorectal cancer patient, comprising classifying said patient as having a good prognosis or a poor prognosis usin..

METHODS OF DIAGNOSING AND TREATING CANCER.

The invention relates to methods of determining an appropriate cancer therapy for a subject based on intratumoral expression levels of Ribonucleotide Reductase M1 (RRM1) and thymidylate synthase (TS) ..

Materials and methods for diagnosis, prevention and/or treatment of stress disorders and conditions associated with abeta peptide aggregation

The subject invention concerns materials and methods for treating and/or preventing diseases associated with accumulation of A[beta] peptide in neural tissue. The subject invention also concerns mater..

METHOD FOR DIAGNOSING SELECTED ADENOCARCINOMAS

A method for the early diagnosing of selected adenocarcinomas in a human comprising the steps of removing a bodily sample from the human, and assaying the bodily sample for elevated expression of a sp..

GENOTYPIC TUMOR PROGRESSION CLASSIFIER AND PREDICTOR

Actively dividing tumors appear to progress to a life threatening condition more rapidly than slowly dividing tumors. Assessing actively dividing tumors currently involves a manual assessment of the n..

TISSUE CLASSIFICATION METHOD FOR DIAGNOSIS AND TREATMENT OF TUMORS

The present invention discloses an informational computation method for classifying objects Specifically, the invention is a system, method, and computer-readable media for classifying tumors using a ..

METHOD AND ASSAY FOR EARLY DIAGNOSIS OF PROSTATE CANCER

A method and assay are described for determining prostate cancer and the general stage of progression of such cancer by quantifying levels of promoter methylation of gal-3, optionally in combination w..

METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF CROHN'S DISEASE

The present invention provides methods and materials, including kits, to evaluate Crohn's disease, including to diagnose, monitor, or determine the efficacy of treatment for Crohn's Disease. The metho..

APPARATUS AND METHOD FOR USE IN ANALYZING A PATIENT'S BOWEL

An apparatus and method are provided for use in studying a patient's bowel which combines recording and analysis of physiologic parameters and patient sensory perception. A pain input detector, a pain..

METHODS OF DIAGNOSIS AND PROGNOSIS FOR A MUSCULAR DYSTROPHY

The invention relates to the treatment, diagnosis, and prognosis of a muscular dystrophy or myopathy. The present inventors have found that the quantity of mu-crystallin is increased in a muscular dys..

IN VIVO BIOFILM INFECTION DIAGNOSIS AND TREATMENT

The present invention relates to a method for in vivo detection of a biof?lm infection residing in a mammal, the method comprising (i) administering to the mammal a diagnostic-effective amount of a bi..

Methods and Systems for Magnetic Focusing of Therapeutic, Diagnostic or Prophylactic Agents to Deep Targets

Systems and methods are disclosed for trapping or focusing magnetizable particles comprising therapeutic agents at a distance using a dynamic magnetic field and feedback control, to enable the treatme..

METHODS AND COMPOSITIONS FOR DIAGNOSING AND MODULATING HUMAN PAPILLOMAVIRUS (HPV)

The present invention concerns methods and compositions for treating a patient having, suspected of having, or at risk of obtaining a HPV infection.

SYSTEMS AND METHODS FOR CATHETER STABILITY

The present invention provides systems and methods for stabilizing catheters, such as decapolar coronary sinus catheters in veins. In particular, the present invention provides fixation elements for i..

PERINUCLEOLAR COMPARTMENT AS A CANCER MARKER

The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provid..

METHODS FOR DIAGNOSING AND TREATING SQUAMOUS CELL CARCINOMA UTILIZING miRNA-205 AND INHIBITORS THEREOF

Disclosed are diagnostic and therapeutic methods related to squamous cell carcinoma. In particular, the diagnostic methods relate to detecting miRNA-205, thereby diagnosing an aggressive form of squam..

RNA From Cytology Samples To Diagnose Disease

The invention relates to methods and kits for detecting the likelihood that a subject has cancer, e.g., squamous cell carcinoma, by assaying the expression levels of tumor associated genes. More speci..

APPARATUS AND METHOD FOR MEASURING A CHARACTERISTIC OF A COMPOSITION REACTIVE TO A MAGNETIC FIELD

A system that incorporates teachings of the present disclosure may include, for example, a sensor having a pulse oximeter sensor to measure an oxygen saturation level in a liquid, a magnetic source co..

LIVE/DEAD VIRAL LOAD ASSAY

The present invention provides viral load assays, kits and methods able to distinguish between active and inactive viruses in a sample. Current diagnostic methods for analyzing the presence of viruses..

DETECTION AND PREDICTION OF PHYSIOLOGICAL EVENTS IN PEOPLE WITH SLEEP DISORDERED BREATHING USING A LAMSTAR NEURAL NETWORK

Apparatus and methods are disclosed for generating and outputting physiological event results from physiological data related to a patient. Physiological event results include results predicting and/o..

METHODS OF DIAGNOSING DIASTOLIC DYSFUNCTION

Diagnostic methods relating to a cardiac ventricular dysfunction are provided. In some embodiments, the diagnostic method is a method of diagnosing diastolic dysfunction in the absence of systolic dys..

METHODS FOR DIAGNOSING ENDOMETRIOSIS

Provided herein is a method for diagnosing and monitoring endometriosis in a subject by measuring levels of the [beta]-subunit of fibrinogen.

DIAGNOSIS OF AGE-RELATED MACULAR DEGENERATION USING BIOMARKERS

The invention relates to proteins associated with age-related macular degeneration (AMD). These proteins, which are present in blood, are expressed in individuals with AMD at either elevated or reduce..

DIAGNOSIS OF ABDOMINAL AORTIC ANEURYSM USING BIOMARKERS

The invention relates to proteins associated with abdominal aortic aneurysm (AAA). These proteins, which are present in blood, are expressed in individuals with AAA at either elevated or reduced level..

COMPOSITIONS AND METHODS FOR DETECTING PREDISPOSITION TO A SUBSTANCE USE DISORDER

The present invention provides screening kits, compositions, and diagnostic methods for determining whether a subject has a predisposition to, or likelihood of having, a substance use disorder by dete..

Diagnosis and Treatment of Age-Related Macular Degeneration

The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of AMD..

DIAGNOSTICS AND THERAPEUTICS FOR GLAUCOMA

The invention provides methods and compositions for diagnosing and treating glaucoma by detecting alterations in the Wnt signaling pathway-including changes in the level or bioactivity of frizzled rel..

Cell's bioactive protein production determining method, involves bonding catch antibody to beads, and analyzing spatial catch-antibody/protein/detection antibody-structures of beads for evaluating pro

The method involves bonding a catch antibody to beads e.g. Dynabeads(RTM: Superparamagnetic, monosized polymer particles). The beads are mixed with a suspension of cells in an analysis container. The ..

A MINIATURIZED, DERMAL-ADHESIVE-BASED DEVICE FOR POSITION-INDEPENDENT, NON-INVASIVE FETAL MONITORING

A system for fetal position-independent, non-invasive fetal monitoring includes a plurality of disposable adhesive patches for placement on an expectant mother's upper and lower abdomen. Each of the p..

GUIDE WIRE ENGAGING URETEROSCOPE

This document discusses, among other things, a ureteroscope having a notch or other structure at a distal end configured to engage a guide wire and facilitate cannulation.

DIAGNOSTIC TEST KITS

This invention provides kits, devices, and methods for the detection of antibodies that recognize one or more proteins and/or antigens from porcine reproductive and respiratory syndrome virus (PRRSV)...

SPINOCEREBELLAR ATAXIA TYPE 8 AND METHODS OF DETECTION

The present invention provides an isolated nucleic acid molecule containing a repeat region of an isolated spinocerebellar ataxia type 8 (SCA8) coding sequence, the coding sequence located within the ..

PREDICTIVE AND DIAGNOSTIC METHODS FOR CANCER

The present disclosure encompasses methods of diagnosing the presence of a cancer, and particularly a cancer of prostate or breast tissue, in a human subject, predicting the outcome or severity of the..

METHODS AND COMPOSITIONS FOR IMPROVED DELIVERY OF THERAPEUTIC AND DIAGNOSTIC AGENTS

Among other things, this disclosure provides for compounds having a targeting moiety linked to a therapeutic moiety and/or a diagnostic moiety; the synthetic methods for making the compounds; pharmace..

METHODS AND SYSTEMS FOR SCREENING FOR AND DIAGNOSING DNA METHYLATION ASSOCIATED WITH AUTISM SPECTRUM DISORDERS

Methods and systems for population screening and diagnostics are provided. In particular methods and systems for population screening of individuals for genetic disorders due to alterations in DNA met..

INTERNET-BASED COGNITIVE DIAGNOSTICS USING VISUAL PAIRED COMPARISON TASK

Disclosed are methods for diagnosing declarative memory loss using mouse tracking to follow the visual gaze of a subject taking a visual paired comparison test. Also disclosed are methods for diagnosi..

FRAGILE X MENTAL RETARDATION PROTEIN (FMRP), COMPOSITIONS, AND METHODS RELATED THERETO

The invention relates to fragile X mental retardation protein (FMRP), compositions, and methods related thereto. In certain embodiments, the invention relates to treating a neurological disorder by ad..

METHODS FOR APPLYING BRAIN SYNCHRONIZATION TO EPILEPSY AND OTHER DYNAMICAL DISORDERS

For analyzing a multi-component system, a method acquires a plurality of signals, each having a different spatial location of the multi-component system, and generates dynamic profiles for each of the..

APPARATUS, SYSTEM, AND METHOD FOR ULTRASOUND POWERED NEUROTELEMETRY

The present embodiments provide an apparatus, system, and method for ultrasound powered neurotelemetry. In one embodiment, the apparatus includes a piezoelectric element configured to receive an ultra..

DIAGNOSTIC AND TREATMENT METHODS FOR CANCER BASED ON IMMUNE INHIBITORS

Methods of diagnosis and treatment of malignant tumors, in particular ovarian tumors, using GD3 and GD3 inhibitors. Also provided are methods of modulating the immune system of a mammal by the adminis..

NEURODEGENERATIVE DISEASE DIAGNOSTIC COMPOSITIONS AND METHODS OF USE

The invention generally provides diagnostics that employ biomarkers altered in neurodegenerative disease, as well as methods for the use of such markers in monitoring disease progression and identifyi..

Medical image analysis apparatus and image analysis control program

A motion function of a biological tissue is efficiently evaluated on the basis of image data collected from different medical image diagnostic apparatuses. In terms of a common analysis algorithm appl..

Protective Complement Proteins and Age-Related Macular Degeneration

Methods for identifying a subject at risk for developing AMD are disclosed. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material. ..

METHOD FOR CONFIRMING A DIAGNOSIS OF ROLANDIC EPILEPSY

A strong association between variants in Elongator Protein Complex 4, (ELP4) (specifically single nucleotide polymorphisms, SNPs) at the 11p13 locus on chromosome 11 and the centrotemporal sharp wave ..

DIAGNOSIS AND THERAPY OF ORGAN DYSFUNCTION USING SPHINGANINE-1-PHOSPHATE

The invention relates to the treatment and diagnosis of organ dysfunction caused by ischemia reperfusion injury. In particular, the invention relates to sphinganine-1-phosphate, a sphingolipid metabol..

INTEGRATED SENSOR NETWORK METHODS AND SYSTEMS

Methods and systems for an integrated sensor network are described. In one embodiment, sensor data may be accessed from a plurality of motion sensors and a bed sensor deployed in a living unit for a f..

IMMUNOASSAY FOR VENOM DETECTION INCLUDING NONINVASIVE SAMPLE COLLECTION

Methods and immunoassays for diagnosing a bite or sting of a venomous organism in a patient having symptoms consistent with such a bite or sting are provided. A sample of venom is collected from the a..

PREDICTION AND DIAGNOSIS OF CANINE DEGENERATIVE MYELOPATHY.

The present invention provides for methods of identifying a dog carrying a major genetic risk factor in the SODl gene for degenerative myelopathy, a potential model for human amyeotrophic lateral scle..

COMPOSITIONS AND METHODS FOR EARLY PREGNANCY DIAGNOSIS

Disclosed are antibodies and methods for detecting pregnancy in an animal. In certain aspects antibodies used binds immunologically to at least two PAGs selected from PAG4, PAG6, PAG9, PAG16, PAG17, P..

METHODS AND COMPOSITIONS FOR DIAGNOSIS OF UROSEPSIS AND URINARY TRACT INFECTION

Methods for diagnosis of, and distinguishing between, urosepsis, sepsis, and urinary tract infections (UTIs) are disclosed The diagnostic methods are based on determining the level of NGAL protein in ..

SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIA FOR HYPERSPECTRAL EXCITATION-RESOLVED FLUORESCENCE TOMOGRAPHY

An exemplary method, system, and computer-accessible medium can be provided for generating three-dimensional image information associated with a fluorescence-exhibiting arrangement within a sample. Fo..

DEVICES, SYSTEMS, AND METHODS FOR EVALUATING VISION AND DIAGNOSING AND COMPENSATING IMPAIRMENT OF VISION

A system and method for evaluating and predicting visual perception of animals are provided. Retinal image data or other data representing the pathology of an animal is provided as input to a nonlinea..

METHODS OF DIAGNOSING, PREVENTING AND TREATING BONE MASS DISEASES

The present invention provides methods and therapeutic agents for lowering or increasing serum serotonin levels in a patient in order to increase or decrease bone mass, respectively. In preferred embo..

USE OF URINARY NGAL TO DIAGNOSE SEPSIS IN VERY LOW BIRTH WEIGHT INFANTS

Methods for diagnosis of sepsis very low birth weight (VLBW) infants are disclosed. The diagnostic methods for sepsis are based on determining whether a bodily fluid sample, such as a urine sample, co..

SERUM-BASED, DIAGNOSTIC, BIOLOGICAL ASSAY TO PREDICT PREGNANCY DISORDERS

The invention provides serum-based, diagnostic, biological assays for predicting disorders of pregnancy resulting from poor trophoblast and/or placental ischemia, including preeclampsia. Serum samples..

METHODS OF DIAGNOSING AND TREATING CARCINOMAS

Methods of diagnosing a carcinoma include comparing the expression of miRNAs in a sample with a control and determining ratios of expression of miRNAs. Methods of treatment include administering a nuc..

DIAGNOSING, PROGNOSING, AND EARLY DETECTION OF CANCERS BY DNA METHYLATION PROFILING

A method of employing DNA methylation analysis for the diagnosis, prognosis, and prediction of cancer.

METHODS AND PRODUCTS FOR DIAGNOSING CANCER

The present invention relates to methods and kits for the detection and diagnosis of cancer or precancerous conditions. Methylation of specific genes has been identified as indicative of cancer and me..

DETECTION OF FRAGMENTS OF NECTIN-1 FOR THE DIAGNOSIS OF ALZHEIMER'S DISEASE

Methods for diagnosing Alzheimer's Disease by detection of fragments of nectin-1 are described. Nectin-1 is shown to be a substrate for proteases associated with the onset of Alzheimer's Disease, incl..

METHODS FOR DIAGNOSING AND TREATING PELVIC PAIN DISORDERS VIA BETA-CATENIN

Methods for diagnosing a pelvic pain disorder that include analyzing samples for increased levels and/or nuclear accumulation of beta-catenin, which indicates presence of the pelvic pain disorder, par..

SIMULTANEOUS AMBULATORY PULSE OXIMETRY AND PH MONITORING FOR THE DIAGNOSIS OF GERD-RELATED RESPIRATORY DISEASE

Respiratory diseases related to gastroesophageal reflux disease in a patient are diagnosed by detecting esophageal or pharyngeal impedance and pH in the patient, detecting oxygen saturation in the pat..

METHODS OF DIAGNOSING AND TREATING FIBROSIS

The present invention is directed to methods of diagnosing and treating a fibrotic condition in a mammalian subject. These methods involve measuring the levels of trimethylation at lysine residue 27 o..

COMPOSITIONS AND METHODS RELATING TO DETECTION OF SOLUBLE E-CADHERIN IN NEURODEGENERATIVE DISEASE

Disclosed herein are compositions and methods for diagnosing, detecting, or monitoring neural disease, conditions, or disorders involving detection of soluble E- cadherin.

APPARATUS AND METHOD FOR CONE BEAM VOLUME COMPUTED TOMOGRAPHY MAMMOGRAPHY

Volume tomographic mammography is performed with a gantry frame (206) in which a cone-beam radiation source (210) and a thin-film detector (208) are mounted. The patient (P) rests on an ergonomically ..

OVARIAN CANCER METHYLOME

The present invention provides methods and kits for identifying a cell that exhibits or is predisposed to exhibiting unregulated growth by detecting hypermethylation of a gene or a regulatory region i..

RECOGNITION OF CYP2E1 EPITOPES

A critical epitope of human cytochrome P4502E1 (CYP2E1) associated with the development of hepatic autoimmune disease, including methods and kits for diagnosis and prognosis using the critical epitope..

METHOD FOR THE DIAGNOSIS OF AGE-ASSOCIATED VASCULAR DISORDERS

Methods for determining if a subject has or is susceptible to having an age- associated vascular disorder are disclosed. The method includes determining if the subject exhibits altered expression of a..

COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING INFLAMMATORY BOWEL DISEASE AND RELATED DISORDERS

The present invention features biomarkers capable of diagnosing inflammatory bowel disease and methods of using such biomarkers to diagnose and selecting treatments for inflammatory bowel diseases.

SYSTEM FOR DIAGNOSIS AND THERAPY OF GAZE STABILITY

A system to measure a subject's gaze stability, comprising: a display device; a data processor in communication with the display device; a data input device in communication with the data processor; a..

NOVEL DESMIN PHOSPHORYLATION SITES USEFUL IN DIAGNOSIS AND INTERVENTION OF CARDIAC DISEASE

This invention relates to novel phosphorylation sites in the desmin protein that are associated with the onset of heart failure. The phosphorylation sites, i.e., Ser-27 and Ser-31, can be used as biom..

NEOEPITOPE DETECTION OF DISEASE USING PROTEIN ARRAYS

A diagnostic device for and method of detecting the presence of head and neck squamous cell carcinoma (HNSCC) in a patient including a detector device for detecting a presence of at least one marker i..

BIOMARKERS FOR DIAGNOSTIC AND THERAPEUTIC METHODS

Erythrocyte ATP-release modulators and composition and methods for their use as biomarkers of glucose processing or vascular disorders, as well as methods for screening to identify to modulators; meth..

GALECTIN-3 nsSNP MARKER FOR CANCER

A diagnostic biomarker including a mechanism for determining a patient's propensity to develop cancer. A diagnostic kit for determining a patient's propensity to develop cancer. A method of predicting..

Treatment and Diagnostic Methods for Fibrosis Related Disorders

The present invention relates to the ability of SAP to suppress fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress fibrocytes. Methods and ..

METHOD FOR DETECTING DISEASE MARKERS

Disease specific markers, in particular cancer markers, can be detected by electrophoretically separating proteins and protein complexes from a biological sample on a protein binding polymeric membran..

AUTOMATED ASSESSMENT OF ATRIOVENTRICULAR AND VENTRICULOATRIAL CONDUCTION

A method discriminates between ventricular arrhythmia and supraventricular arrhythmia by determining the direction of an electrical signal conducted through the atrioventricular node. An implantable c..

DIAGNOSTIC AND THERAPEUTIC USES OF AUGMENTER OF LIVER REGENERATION IN INFLAMMATORY CONDITIONS

The present invention provides for methods and kits for detecting sepsis, trauma/hemorrhage or inflammation in a subject. It is based, at least in part, on the discovery that Augmenter of Liver Regene..

MARKER PANELS FOR IDIOPATHIC PULMONARY FIBROSIS DIAGNOSIS AND EVALUATION

The present invention relates to the discovery that of a panel of serum or plasma markers may be used to diagnose Idiopathic Pulmonary Fibrosis ("IPF") and distinguish this condition from other lung a..

THERAPEUTIC AND DIAGNOSTIC CLONED MHC-UNRESTRICTED RECEPTOR SPECIFIC FOR THE MUC1 TUMOR ASSOCIATED ANTIGEN

The invention provides an isolated nucleic acid encoding a receptor, other than an immunoglobulin, wherein the receptor binds to a MUC1 tumor antigen independently of an major histocompatibility compl..

PREDICTION AND PREVENTION OF PREECLAMPSIA

The present disclosure relates to methods for assessing increased risk of preeclampsia in a pregnant woman. The methods described herein employ measuring relaxin levels, and optionally measuring C-rea..

METODO EN TIEMPO REAL PARA DETECTAR TRASTORNOS INFLAMATORIOS AGUDOS.

Un método para diagnosticar o monitorear lupus eritematoso sistémico (SLE) en un individuo, el método caracterizado porque comprende: (a) determinar el nivel de un componente de trayectoria del com..

METHOD FOR DIAGNOSING RENAL DISEASES OR PREDISPOSITIONS

The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a mut..

ANTICANCER VACCINE AND DIAGNOSTIC METHODS AND REAGENTS

The invention provides a method for vaccinating a patient against a malignancy comprising introducing a protein or peptide comprising of all or an immunogenic fragment of a cyclin protein into the pat..

METHODS TO DIAGNOSE AND IMMUNIZE AGAINST THE VIRUS CAUSING HUMAN MERKEL CELL CARCINOMA

The present invention provides isolated or substantially purified polypeptides, nucleic acids, and virus-like particles (VLPs) derived from a Merkel cell carcinoma virus (MCV), which is a newly-discov..

MONOCLONAL ANTIBODIES FOR CSPG4 FOR THE DIAGNOSIS AND TREATMENT OF BASAL BREAST CARCINOMA

It is disclosed herein that condroitin sulfate proteoglycan 4 (CSPG4), also known as high molecular weight melanomal associated antigen, is overexpressed on basal breast carcinoma cells (BBC), specifi..

SYSTEM AND METHOD FOR ASSESSING CANCER RISK

Methods and systems for determining a probabilistic assessment of a person developing cancer are disclosed. The probabilistic assessment may include receiving a digital breast image of a person, selec..

METHODS AND COMPOSITIONS USING SPLICING REGULATORY PROTEINS INVOLVED IN TUMOR SUPPRESSION

Methods and compositions for diagnosis and prognosis of mammalian carcinoma or cancer derived from primary epithelial cells and tissue fibrosis are designed using newly identified epithelial cell-type..

RECOMBINATION SEQUENCE (RS) REARRANGEMENT FREQUENCY AS A MEASURE OF CENTRAL B CELL TOLERANCE

The invention relates to methods and materials for diagnosing an autoimmune disease such as SLE, Type 1 diabetes, and the like. More particularly, the invention relates to methods and materials for as..

PARAMAGNETIC POROUS POLYMERSOMES AND USES THEREOF

The invention relates to porous polymerosoms and their use in diagnosis and prognosis of diseases. Specifically, the invention relates to porous polymerosoms comprising lanthanides and their uses.

METHOD OF DIAGNOSING AND TREATING INTERSTITIAL CYSTITIS

A method for diagnosing, or differentially diagnosing, interstitial cystitis (1C) involves detecting or measuring increased expression of a biomarker Endothelin 1 (ET-I) in a biological sample from a ..

ANTI-TEM1 ANTIBODIES AND USES THEREOF

The invention relates to Anti-TEM 1 antibodies or antigen-binding fragments thereof, yeast libraries comprising the same, and prophylactic, diagnostic, and therapeutic methods using the same.

METHODS FOR DIAGNOSING AND TREATING ENCEPHALITIS OR EPILEPSY

This invention provides methods of diagnosing or determining a cause of an autoimmune encephalitis or an epilepsy in a subject and of diagnosing a tumor in a subject, comprising the step of testing a ..

Compositions and Methods for the Diagnosis and Treatment of Amyotrophic Lateral Sclerosis

Compositions and methods for diagnosis and treatment of ALS are provided.

METHOD FOR IMMUNE RESPONSE DETECTION

A method for detecting one or more immunological response factors that is expressed in response to a therapeutic treatment and/or disease using a piezoelectric microcantilever sensor (PEMS) to assess ..

A HIGH PRECISION QUANTITATIVE ASSAY COMPOSITION AND METHODS OF USE THEREFOR

The invention features compositions and methods that are useful for precisely determining the amount of one or more analytes present in a sample. In one aspect, the invention provides a composition fo..

Mutations of the PIK3CA gene in human cancers

Phosphatidylinositol 3-kinases (PI3Ks) are known to be important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in cancers, we analyzed the sequences of the P13K ..

DETECTION OF AUTO-ANTIBODIES TO SPECIFIC GLYCANS AS DIAGNOSTIC TESTS FOR AUTOIMMUNE DISEASES

The invention provides uses, methods, and kits for diagnosing an autoimmune disease, particularly scleroderma and systemic lupus erythematosus, in a subject by detecting the presence of one or more an..

Methods for the Diagnosis and Treatment of Lung Cancer

The present invention provides methods for aiding in the diagnoses of the neoplastic condition of a lung cell and methods of screening for a potential therapeutic agent for the reversal of the neoplas..

METHOD, KIT OR DIAGNOSTIC FOR THE DETECTION OF REAGENTS WHICH INDUCE ALTERED CONTRACTILITY

A method of screening for compounds that enhance or depress contractile function, based on measuring the formation of heterodimers of contractile fibers (e.g. Tm and actin, myosin heavy and myosin lig..

MICRORNA-BASED DIAGNOSTIC TESTING AND THERAPIES FOR INFLAMMATORY BOWEL DISEASE AND RELATED DISEASES

The present invention is based, at least in part, on the novel discovery that certain microRNAs are associated with inflammatory bowel diseases and other related diseases. Accordingly, the invention r..

SR-BI AS A PREDICTOR OF HUMAN FEMALE INFERTILITY AND RESPONSIVENESS TO TREATMENT

Methods of diagnosis and treatment of diseases and disorders related to de novo synthesis of cholesterol, based on allelic variants of the scavenger receptor class B type I receptor, and kits for use ..

DETECTION OF PROSTATE CANCER USING PSA GLYCOSYLATION PATTERNS

The present invention features novel methods for determining if a subject has prostate cancer. The present invention is based on the development of lectin immunosorbant assays which analyze [alpha]2,6..

IMAGE-BASED RISK SCORE-A PROGNOSTIC PREDICTOR OF SURVIVAL AND OUTCOME FROM DIGITAL HISTOPATHOLOGY

The present invention relates to an image-based computer-aided prognosis (CAP) system and method that seeks to replicate the prognostic power of molecular assays in histopathology and pathological pro..

TREATMENT AND DIAGNOSIS OF INFLAMMATORY DISORDERS

This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders.

GENES AS DIAGNOSTIC TOOLS FOR AUTISM

The homeobox transcription factor, ENGRAILED 2 EN2), was investigated for association with autism spectrum disorder (AS) by performing transmission/disequilibrium tests (TDT) for two SNPs (rs1861972 a..

MOLECULAR CIRCUITS

Disclosed herein are autonomous molecular circuits that can function in cells. The circuits can process logical operations in which one or more input cues are among the operands and produce an appropr..

PEPTIDES AND NANOPARTICLES FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS

Provided herein are peptides and nanoparticles conjugates thereof useful for the treatment of diseases and disorders mediated by GIPC/synectin, such as cancer.

SYSTEM AND METHOD FOR USE OF NANOPARTICLES IN IMAGING AND DIAGNOSIS

A method for diagnosing certain types of cancers provides a nanoparticle agent to be uptaken by cancer cells for diagnosis and treatment of certain cancers. A compound containing nanoparticles is dire..

Methods for diagnosing and treating neuroendocrine cancer

The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods fo..

DISTRIBUTED FAULT DIAGNOSIS

A distributed diagnosis algorithm based on a multi-signal digraph model of an overall system is provided. In addition, a model enables the generation of a fault-test dependency matrix (D-matrix), whic..

Methods for the Detection and Monitoring of Congestive Heart Failure

Disclosed herein are methods of detecting and/or prognosing congestive heart failure by detecting a proteolytic fragment of caspase-3 such as the p17 fragment or the p12 fragment. The congestive heart..

DEVICE, INSTRUMENT AND PROCESS FOR DETECTING MAGNETICALLY LABELED ANALYTES

The present invention is directed to a device for quantitative analysis of an analyte in a liquid sample by detecting a magnetic label, an instrument for controlling the analysis process and displayin..

ANALYSIS OF ENDOGENOUS FLUORESCENCE IMAGES TO EXTRACT MORPHOLOGICAL/ORGANIZATION INFORMATION ABOUT LIVING SAMPLES

Methods and computer program products for analyzing tissue are provided. The tissue is exposed to light at the appropriate wavelengths for inducing fluorescence. Images of the fluorescing tissue are t..

METHODS FOR DIAGNOSIS OF CLOSTRIDIUM DIFFCILE AND METHODS AND VECTORS FOR RECOMBINANT TOXIN EXPRESSION

Cell-based methods for rapid real time assay of a presence of Clostridium difficile toxin and/or cells are provided, using an assay having a toxin-enhancing antibody and a sensitive cell line carrying..

MULTIFACTORIAL METHODS FOR DETECTING LUNG DISORDERS

Described herein are multifactorial methods for detecting, diagnosing or aiding in the diagnosis of lung disorders or disease, e.g., lung cancer. The methods disclosed utilize multiple diagnostic para..

SUPRAMOLECULAR BIOCONJUGATES

The invention relates to supramolecular bioconjugates and to methods for assembling and utilizing supramolecular bioconjugates. Supramolecular bioconjugates comprise a plurality of first nucleic acids..

CLASSIFICATION TECHNIQUES FOR MEDICAL DIAGNOSTICS USING OPTICAL SPECTROSCOPY

Mathematical/statistical pattern-recognition systems and methods to distinguish between different pathologies and benign conditions (e.g., normal or cancerous tissue) given spectra measured using opti..

Haplotype Analysis

The present invention provides an efficient way for high throughput haplotype analysis. Several polymorphic nucleic acid markers, such as SNPs, can be simultaneously and reliably determined through mu..

Methods for prenatal diagnosis of chromosomal abnormalities

Chromosomal abnormalities are responsible for a significant number of birth defects, including mental retardation. The present invention is related to methods for non-invasive and rapid, prenatal diag..

METHOD FOR DETECTING AND QUANTIFYING RARE MUTATIONS/POLYMORPHISMS

The present invention is directed to a method for detecting and quantifying rare mutations in a nucleic acid sample. The nucleic acid molecules under investigation can be either DNA or RNA. The rare m..

GLUTAMINE ENDOPEPTIDASES D'ESPÈCE ROTHIA ET UTILISATION DE CELLES-CI

Disclosed are glutamine endopeptidase enzymes from Rothia sp. bacteria that are naturally associated with the oral cavity, formulations comprising the glutamine endopeptidase enzymes and the use there..

EARLY DIAGNOSIS OF ACUTE CORONARY SYNDROME

The invention relates to methods for the early diagnosis of Acute Coronary Syndrome.

DIAGNOSTIC USES OF ANTI-H8 MONOCLONAL ANTIBODIES

The invention relates to diagnostic and therapeutic uses of antibodies or antigen- binding fragments that recognize the H8 antigen, an outer membrane protein of Neisseriae. Some aspects relate to phar..

ST2-BASED DENGUE FEVER DIAGNOSTIC

A cytokine receptor family member (ST2), which has membrane bound as well as soluble bound forms, is elevated in patients during acute phase of dengue fever. Moreover, secondary cases of dengue fever ..

Use of IMP3 as a Prognostic Marker for Cancer

Provided herein are methods and compositions for the prognostic evaluation of a patient suspected of having, or having, cancer by assessing the expression of IMP3 in a biological sample of a patient. ..

ESPFU NUCLEIC ACIDS AND PROTEINS AND USES THEREOF

Disclosed are EspFU (EspF-like polypeptide encoded by a gene of the cryptic prophage CP-933U of enterohemorrhagic E. coli) polypeptides, fragments thereof, nucleic acids that encode EspFU polypeptides..

METHODS FOR DIFFERENTIAL DIAGNOSIS OF MELANOCYTIC LESIONS

The invention provides a method for determining whether a melanocytic lesion in a patient is malignant which comprises determining a quantity of gp100 present within a nuclear compartment in stained c..

METHODS FOR A PREDICTIVE DIAGNOSTIC TEST FOR TAMOXIFEN

A method for determining the likelihood that a therapy involving administration of tamoxifen to a patient afflicted with an estrogen receptor positive breast cancer will provide a therapeutic benefit ..

METHODS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF PREECLAMPSIA

Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.

Diagnosis and Treatment of Age Related Macular Degeneration

Methods, compositions and kits for diagnosis and treatment of age related macular degeneration.

Excitatory glycine receptors and methods

The invention provides isolated N-methyl-D-aspartate type 3B (NR3B) polypeptides, functional fragments and peptides, encoding nucleic acid molecules and polynucleotides, and specific antibodies. Also ..

DIAGNOSIS OF PREECLAMPSIA

The present invention provides methods and compositions related to the detection and/or monitoring of the levels of angiogenic factors, specifically VEGF, PlGF and sFlt-1, in urine samples obtained fr..

METHOD FOR CELL IDENTIFICATION AND QUANTIFICATION WITH GOLD NANOPARTICLES THROUGH HYDROGEN ION REDUCTION

The method for cell identification and quantification comprises bonding specific surface proteins of cells immobilised on the surface of the electrochemical transducer with specific antibodies conjuga..

METHOD AND KIT FOR THE DIAGNOSIS OF COAGULATION DISORDERS

The invention relates to a method for diagnosing coagulation disorders by determining dense granule deficiencies in platelets. The method can be used to detect the inorganic polyphosphate content of b..

USE OF THE MASP-52 PROTEIN FOR THE DIAGNOSIS, TREATMENT AND PREVENTION OF CHAGAS DISEASE

The invention relates to the use of the MASP-52 protein, from the mucin-associated surface protein (MASP) family, for the diagnosis, treatment and prevention of Chagas disease, including a method for ..

METHOD AND KIT FOR DIAGNOSING MANTLE CELL LYMPHOMA

The invention relates to a method and kit as useful tools for classifying a patient diagnosed with mantle cell lymphoma as indolent or conventional. The method comprises: a) providing a sample from a ..

METHOD FOR THE DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE BY DETECTING VOLATILE ORGANIC COMPOUNDS IN EXHALED AIR

The present invention relates to the identification of markers for the disease conditions related to Inflammatory Bowel Disease. The uses of such markers in diagnosis of inflammatory Bowel Disease and..

METHOD FOR THE DIAGNOSIS OF ASTHMA BY DETECTING VOLATILE ORGANIC COMPOUNDS IN EXHALED AIR

The present invention relates to the identification of markers for the disease conditions related to asthma. The exhaled air of the patient is analysed with GC-MS and the amount of asthma markers m th..

METHOD FOR THE DIAGNOSIS OF CYSTIC FIBROSIS BY DETECTING VOLATILE ORGANIC COMPOUNDS IN EXHALED AIR.

The present invention relates to the identification of markers for the disease conditions related to cystic fibrosis (CF) The uses of such markers in diagnosis and a novel method for their identificat..

DIAGNOSTIC AND THERAPEUTIC TOOLS FOR DISEASES ALTERING VASCULAR FUNCTION

The invention relates to diagnostic and therapeutic tools and applications, particularly useful in diseases that affect vascular health and in inflammatory diseases. In particular, said diagnostic and..

MEANS AND METHODS FOR DIAGNOSING AND/OR TREATING A SUBJECT AT RISK OF DEVELOPING HEART FAILURE

The present invention relates to a method for identifying a subject at risk of developing heart failure, comprising: (a) determining the level of one or more biological markers in a biological sample ..

Method for identifying a subject at risk of developing heart failure by determining the level of galectin-3 or thrombospondin-2

The present invention relates to a method for identifying a subject at risk of developing hypertensive end organ damage, such as and in particular heart failure, comprising: a) obtaining a biological ..

MODEL SYSTEM FOR DIAGNOSING LIPID METABOLISM

The invention relates to a population model for the analysis of blood lipoprotein physiology in a test subject comprising: a. a submodel for the production of blood lipoproteins; b. a submodel for the..

Gene signature for replicative senescence in cell cultures

The present invention relates to the field of diagnostics. Specifically, it relates to means and methods for determining the replicative senescence status of a cell culture and for assessing the suita..

CORRECTION OF PHASE ERROR IN MAGNETIC INDUCTION TOMOGRAPHY

The invention relates to correcting signals measured in magnetic induction tomography with regard to a phase error. In the tomography system, an object (OBJ) is exposed to alternating magnetic fields ..

METHOD FOR DETECTING A WOUND INFECTION

he present invention relates to a method for detecting a wound infection comprising the steps of : - contacting a sample obtained from a wound with at least two substrates for at least two enzymes sel..

Method for monitoring collagen type II degradation in cartilage

A method for improving the diagnostic assessment of cartilage degenerative processes, and to provide means of monitoring the effects of therapeutical measures taken towards arthritic diseases in most ..

Detection of specific nitrated markers

Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, an..

GDF15 AS A DIFFERENTIAL MARKER FOR SPONDYLOARTHROPATHY

In vitro methods for differential diagnosis of spondyloarthropathy are disclosed which involve determining the levels of GDF15 in biological samples.

BLOOD SERUM MARKER FOR DETECTION AND DIAGNOSIS OF ALZHEIMER'S DISEASE

The present invention relates to a blood marker for early detection and diagnosis of Alzheimer's disease. More specifically, it relates to an analysis of the protein glycan profile in the blood, and t..

REMOTE CENTRE OF MOTION POSITIONER

Apparatus comprising a member (6) arranged to revolve about a remote centre of motion (O) and a base link (3) coupled to a mounting fixture (1). A first link (4) and a second link (5) are pivotably co..

HAPLOTYPE OF KATIII GENE

The present invention relates to a diagnostic marker comprising at least one single nucleotide polymorphism (SNP) in the human KATIII gene, as well as to a method for the detection of a predisposition..

NEW METHODS FOR DIAGNOSING AUTOIMMUNE DISEASES

The present invention relates to new methods of diagnosing several autoimmune diseases. More particularly the present invention relates to methods and compositions for detecting anti-heterogeneous nuc..

NOVEL FLUORESCENT BORON-SUBSTITUTED DIPYRROMETHENES AND USE THEREOF FOR DIAGNOSIS

The invention relates to novel fluorescent compounds derived from non-fluorinated dipyrromethene-boron, to a method for preparing same and to the use thereof for the fluorescent marking of biological ..

METHOD AND DEVICE FOR READING AN EMULSION

The present invention relates to a method for reading an emulsion (3) comprising drops and a continuous phase surrounding the drops, wherein said method comprises: two-dimensional scanning of the emul..

DEVICE FOR RECONSTRUCTING SPEECH BY ULTRASONICALLY PROBING THE VOCAL APPARATUS

The invention relates to a portable device for speech recognition and/or reconstruction by ultrasonically probing the vocal apparatus, wherein the device comprises at least one ultrasonic transducer (..

MONITORING TARGET ENDOGENOUS SPECIES

An electrode comprising a conducting substrate for detecting species such as nitric oxide (NO), carbon monoxide (CO), oxygen (O2) and hydrogen (H2) and a polymer matrix formed from a first layer only ..

GENETIC VARIATION ASSOCIATED WITH COELIAC DISEASE

The present invention provides a method of diagnosing coeliac disease, said method comprising analysing a sample of nucleic acid from a human subject to determine the presence or absence of one or mor..

PLATELET ANALYSIS

The present invention relates to a method, including a diagnostic method, for characterising platelets. More particularly, the invention relates to methods for characterising platelets by immobilising..

METHOD FOR EARLY DETECTION OF CANCER

The present inventors have demonstrated that circulating auto-antibodies to cancer antigens hold promise as specific and sensitive biomarkers for the early detection of cancer. The present invention t..

DIAGNOSTICS IN A MONOPLEX/MULTIPLEX FORMAT

The present invention relates to a method of detecting and/or quantifying a target molecule from a sample obtained from a subject wherein the method comprises: (i) incubating a fusion protein or conju..

METHOD AND APPARATUS

A method of providing cognitive training to a user, the method including, in a processing system, presenting a cognitive task to a user, the cognitive task requiring the user to view presented informa..

DIAGNOSTIC AND THERAPEUTIC PROTOCOLS

The present invention relates generally to the fields of diagnostic assays and therapeutic protocols with respect to viral infection.

A METHOD OF PROVIDING QUANTITATIVE INFORMATION ABOUT THE LOWER AIRWAYS OF A LUNG

The present disclosure provides a method of providing quantitative information about a property of the lower airways of a lung using optical coherence tomography. The method comprises inserting a prob..

DETERMINANTS OF THE ACUTE SICKNESS RESPONSE

The present invention relates to a method for predicting the severity of an acute sickness response in a subject, said method comprising detecting the presence of a polymorphic marker in the subject, ..

METHOD FOR DETECTION OF ENDOMETRIOSIS

A method for use in diagnosis of endometriosis in a subject comprising detecting a cytokeratin (19) gene product in a biological sample from said subject, wherein detection of the cytokeratin (19) gen..

NOVEL COMPOUNDS AND THEIR USES IN DIAGNOSIS

A compound of formula (I) wherein, X and Y independently bind TSPO, wherein X and Y are the same or different; and L is a linker that links X to Y; or a salt or solvate thereof. For preference, X and ..

NITROGEN-CONTAINING MACROCYCLIC CONJUGATES AS RADIOPHARMACEUTICALS

The present invention relates to compounds that are useful as metal ligands and which either contain a molecular recognition moiety or can be bound to a molecular recognition moiety and methods of mak..

Antigenic complex for the diagnosis and treatment of porphyromonas gingivalis infection

Disclosed is a purified multimeric complex from P. gingivalis, the complex comprising at least one domain from each of RgpA, Kgp and HagA, and having a molecular weight greater than about 300 kDa. Als..

PUPILLARY ASSESSMENT METHOD AND APPARATUS

A system and method for assessing the function of parts of the nervous system of a subject by measuring the pupillary responses to at least one stimulus ensemble comprising a plurality of individual s..

SCREENING METHODS AND SEQUENCES RELATING THERETO

A screening method for identifying an individual having a pre-disposition towards having a cancer is disclosed, which screening method comprises the steps of: (a) obtaining a test sample comprising a ..

DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE

The invention relates to novel variants that associate with Alzheimer's disease AD and their use in kits as a means for diagnosing AD; and also their use in nucleic acid molecules or cells/cell lines ..

METHOD AND KIT FOR THE CLASSIFICATION AND PROGNOSIS OF WOUNDS

The invention relates to a method and kit for identifying chronic or acute mammalian wound tissue or for determining the prognosis of mammalian wound tissue based upon the identification of at least o..

ASSAY FOR DETECTION OF ADRENAL TUMOUR

The invention relates to methods, assays and kits for detecting or monitoring adrenal tumours by detecting one or more adrenal steroid metabolites. The metabolites are selected from THS (tetrahydro-11..

METHOD FOR DIAGNOSING AND TREATING MUSCULAR DYSTROPHY

The invention describes a method for identifying an individual exhibiting symptoms of, or having a propensity to develop muscular dystrophy comprising determining the level of expression in a tissue s..

SCREENING METHOD

The present invention relates to clinical diagnosis of Alzheimer's disease or early- stage Alzheimer's disease in the live patient. In particular, the invention provides a screening method which can b..

AUTOMATIC DISCRIMINATION OF DYNAMIC BEHAVIOUR

There is described a distributive sensing technology that is able to discriminate between the causes of dynamic disturbances. The system applies a limited number of sensing elements within a sensing m..

SYSTEM FOR DIAGNOSIS AND TREATMENT OF PHOTOVOLTAIC AND OTHER SEMICONDUCTOR DEVICES

A diagnostic and self-healing treatment system for a semiconductor device, the system provides: i) a shunt busting/blocking treatment, ii) self-healing treatment, and iii) an in-situ non-contact diagn..

NA/K-ATPASE EXPRESSION AS AN INDICATOR FOR THE TREATMENT OF CANCER

Methods for regulating the expression of Na/K-ATPase and uses thereof, including uses in the diagnosis/prognosis and treatment of cancer, are disclosed.

SOLUBLE GUANYLYL CYCLASE A1 AND A-8R PEPTIDE AS DIAGNOSTIC MARKERS OF AND THERAPEUTIC TARGETS FOR PROSTATE CANCER

The present invention provides materials and methods useful to treat various sGCal- expressing cancers. Materials include peptides which interfere with sGCal's pro-survival functions, thereby resultin..

FLUID SAMPLING DEVICE

Disclosed is a fluid sampling device comprising a plurality of inlet channels, each of which is arranged to receive an airflow from an associated direction, such that a sampling medium associated with..

BIOMARKER

Described are gastrointestinal cancer specific biomarkers comprising the nucleic acid sequence of the Engrailed-2 (EN2) gene or the amino acid sequence of the encoded EN2 protein. Also described are u..

METHOD FOR AIDING THE DIAGNOSIS OF BILIARY ATRESIA BY DETERMINING THE LEVEL OF ADMA IN A BLOOD SAMPLE

The invention relates to a method for aiding the diagnosis of bilial atresia in a subject, said method comprising (i) determining the level of ADMA in a blood sample from said subject, wherein said bl..

MARKER

The invention provides a method for identifying whether a pregnant subject has an increased risk of preterm labour comprising measuring the progesterone concentration in a sample obtained from the sub..

IMAGING SYSTEM

A method of obtaining, in a single exposure, imaging information from an object (16) representative of more than two distinct illumination images, the method comprising the steps of generating first e..

CMYBP-C AND MLC2 AS DIAGNOSTIC MARKERS OF CARDIAC INJURY

The invention relates to markers for acute myocardial infarction (AMI), particularly markers that may be used in the rapid and accurate diagnosis of AMI or reinfarction. A method of diagnosing cardiac..

PEPTIDIC CONJUGATES COMPRISING POLYHISTIDINE SEQUENCE AND FREE CYSTEINE AND THEIR USES IN IMAGING

Bioconjugates for use in imaging are disclosed include a linker sequence fused to a polypeptide capable of binding a target in a biological system. The linker sequence is designed so that it is capabl..

PHOSPHODIESTERASE 4D7 AS PROSTATE CANCER MARKER

The present invention relates to phosphodiesterase 4D7 (PDE4D7) for use as a marker for prostate cancer, and the use of PDE4D7 as a marker for diagnosing, detecting, monitoring or prognosticating pros..

IMPROVED METHOD OF DETERMINING METABOLIC FUNCTION

The present invention provides a novel lactate difference imaging (LDI) technique, allowing assessment of the metabolic responses of tissue over a period of time. This approach utilises lactate change..

SIGMA LIGANDS AND IKK / NF - KB INHIBITORS FOR MEDICAL TREATMENT

The present invention relates to agents that act in concert with sigma receptor ligands to enhance their effectiveness in the treatment of cancer and inflammatory disease. It also relates to methods w..

APPARATUS AND METHOD FOR THE DETECTION OF CELLS

An apparatus and method for in-vivo detection of magnetically labelled biological molecules or cells, located in a flowing medium in a human or animal body such as the blood stream (13). The apparatus..

DIAGNOSIS AND TREATMENT OF CELL PROLIFERATION AND DIFFERENTIATION DISORDERS BASED ON THE FMN2 GENE

The present invention provides methods for diagnosing cell proliferation and/or differentiation disorders, compounds and methods for treating the same and methods for identifying agents potentially us..

Image quality evaluation device and method

An image quality evaluation device is disclosed in the present invention, including: an image analyzer, adapted to analyze the parameters of an image to obtain parameter values; and an evaluation unit..

NUCLEIC ACID AMPLIFICATION AND TESTING

Methods for amplifying a target nucleic acid by self-sustained amplification methods are described. The methods are designed, in particular, to be carried out without use of specialised lab facilities..

BIOSENSOR FOR ANALYTE DETECTION

This invention relates to biosensors for detecting analyte molecules, such as nucleic acids, in a sample solution. The biosensors comprise a capture electrode which has probe molecules immobilised at ..

METHODS FOR REDUCING FALSE HYPOGLYCEMIA ALARM OCCURRENCE

A system and method for reducing the number of hypoglycemic alarms presented to a user is presented. The system and methods include use of model based state estimation and variable-delayed threshold v..

VISUAL PERIMETER MEASUREMENT SYSTEM AND METHOD

In one example of the invention a patient display is provided on which a fixation graphic or video is shown in substantially the centre of the display, and then target graphics or video are shown at d..

BIOMARKERS FOR SCHIZOPHRENIA OR OTHER PSYCHOTIC DISORDERS

The invention relates to a method of diagnosing or monitoring schizophrenia or other psychotic disorder. Schizophrenia is a psychiatric diagnosis that describes a mental disorder characterized by a..

SCD Fingerprints

This invention relates to methods of testing, diagnosing, monitoring, prognostically stratifying and classifying disease, disorders and other medical conditions and physiological states through the de..

Apparatus for variably cycling the depth of water in a water tank

Apparatus for variably cycling the depth of water in a water tank (4, 4A) between an upper water level and a lower water level. The apparatus comprises a water outlet aperture (5,5A) for location in t..

Measuring amt. of contamination in soft solder bath - by converting sonic pulses produced in metal probe dipped into bath into electrical pulses and plotting curve of phase summation against time

Method of quantitatively and qualitatively determining the degree of metal impurity in a soft soldering bath consists of monitoring the sonic impulses emitted as an intermetallic phase grows on the su..

Increasing measuring precision for FMCW radar - uses auxiliary signal to mix again with differential mixing signal from transmit and reception signals

The measuring precision of an FMCW radar for location of reflection in optical fibres (LWL) is increased by forming differential frequency of a mixing signal (fM) from transmit and reception signal. T..

SAFETY METHOD FOR HEATING DEVICES AND SAFETY DEVICE FOR PERFORMING SAID METHOD

The method involves monitoring operation of a heating device (11) such that the heating device is deactivated by a control device (14) of a safety device by deviation of the operation from operation d..

Method for testing a protective device and correspondingly equipped protective device and testing device

The method involves testing an operating procedure of a protection device (1), where functions of the procedure requires a preset operation time period during utilization of the device for protecting ..

Laser Imaging System to Assess the Vitality of Pulpal Chamber of Teeth

Brief Description Researchers have developed a laser imaging system that accurately assesses the pulp vitality of a tooth. This system can assess and image the pulp vitality without pain to the pati..

Label-Free Protein Detection

Background Conventional methods to detect the presence or quantity of specific proteins or other molecules in biological samples rely on the use of target-specific probes such as antibodies, which c..

DNA Binding Compounds for Genetic Regulation and Medical Diagnosis and Therapy

Compounds that bind to DNA could be used to target drugs to DNA and to regulate expression of genes. Indeed, many compounds have been discovered (e.g. Distamycin) which bind to the minor groove of DN..

Inexpensive, Sensitive, Rapid and Selective Detection of GHB (Gamma-Hydroxybutyrate)

Researchers at the University of California have invented a rapid, selective, sensitive, and inexpensive enzyme-based colorimetric assay for GHB that will provide means by which: * People can prote..

Use of Vanadium Bromoperoxidase as a Signal-Generating Enzyme for Chemiluminescent Systems: Test Kits and Analytical Methods

PATENT ABSTRACT: Aqueous compositions, test kits and methods can be used to detect hydrogen peroxide or vanadium bromoperoxidase by generating a chemiluminescent signal in the presence of the analy..

A Method for In Vivo Visualization of Mutated Mouse Cells

BACKGROUND: One method of studying tumors in mice is by using the CRE recombination system to delete or overexpress cancer-control genes in particular tissues at particular times. However, a hurdle in..

Hybrid Energy Transfer for Nucleic Acid Detection

BACKGROUND: The need for efficient assays to detect DNA sequences is enormous and constantly growing. The recent increases in the number of sequenced genomes for bacterial and viral pathogens as well ..

A Combined Gene-Based Test for Guiding Therapy in Colon Cancer

This method employs two separate molecular screening tests: one that tests for mutation in the BRAF gene sequence (reported in colon cancer), and one that tests for microsatellite instability (MSI) am..

A prognostic test for B-cell chronic lymphocytic leukemia

Background Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia in the Western world. The American Cancer Society estimated 15,340 new cases of CLL and 4500 deaths ..

Antibodies for Amyotrophic Lateral Sclerosis

The Background Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease affecting primarily motor neurons of the motor cortex, brainstem and spinal cord. Pathological hallma..

Method for Determining Peripheral Breast Thickness

Background Each year, 182,000 women are struck by breast cancer in the United States alone. The earlier the disease is detected, the better the prognosis. To this end, there are about 14,000 mamm..

An Optical Method to Measure the Thickness of Compressed Objects

Background Each year, 182,000 women are struck by breast cancer in the United States alone. The earlier the disease is detected, the better the prognosis. To this end, there are about 14,000 mamm..

Low-cost Flexible Manufacturing Techniques for Bradbury-Neilson Gates and Similar Interdigital Structures for Use in Miniature Time-of-Flight Mass Spectrometers and Other Related Applications

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland security and the medical community lead the list. Current instruments ..

Molecularly Imprinted Polymer Sensor for 2-Phosphonobutane 1,2,4 Tricarboxylic Acid

Cooling towers, which are an inexpensive and environmentally friendly method to control process and building temperatures, require the addition of anti-fouling and corrosion inhibiting chemicals. PBTC..

Flash Hit Detector

A sensor array system for detecting the position of an object or energy source. The system includes a plurality of sensors, each sensor having a limited field of view and being capable of detecting an..

Method and System for Detecting Small Structures in Images

The potential difficulties and pitfalls of many automated detection techniques can be summarized as follows: a. Too little enhancement may preclude the detection of minor microcalcification peaks whil..

Fiber Optic Ionizing Radiation Detection

An ionizing radiation detector employs optical fibers as the medium for sensing ionizing radiation emitted by a radioactive source. Light in the infrared region is pumped continuously through an optic..

Capacitive Chemical Sensor Using an Ion Exchange Surface

A capacitive chemical sensor is disclosed that uses an ion exchange layer to detect analyte ions in a liquid medium. An exchange mechanism occurs on the surface of the ion exchange layer, wherein port..

Fluorine Reporter Groups Easily Attached to Biomolecules for MR Imaging

Abstract (Set) Accordingly, the present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies...

Monoclonal Antibody

Abstract (Set) A rat hybridoma producing a high-affinity IgG2a monoclonal antibody (B3B4) directed against the murine lymphocyte IgE receptor (FcR) was established by using purified FcR from FcR+ mur..

CF Mutations in the CFTR Gene

Mutations were found in the cystic fibrosis conductance regulator protein (CFTR) between codons 548 - 560. These mutations are associated with the cystic fibrosis phenotype and provide a genetic scree..

Anti-viral Target For Herpes Virus

Abstract (Set) A herpes virus proteinase has been identified and cloned from cytomegalovirus. The substrate for the proteinase, which is an assembly protein precursor, has also been identified. The p..

Exemer Ablation Within Bowman

Abstract (Set) Method and apparatus for laser ablation of the cornea to correct strabismus. The laser beam is controlled by a system of limiting shutters to cut prism lenses into the cornea. The abla..

Occlusion of Subretinal Vascular Beds by Laser Targeted Photodynamic Therapy

The methods and materials in this invention relate to selective and non-invasive visualization, or treatment such as chemical occlusion, of vasculature in the mammalian eye. The methods utilize fluore..

Occlusion of Subretinal Vascular Beds by Laser Targeted Photodynamic Therapy

Multivariate Statistical Modeling Biomarkers as Predictors of Recurrence Following Radical Prostatectomy

A method for screening individuals at risk for prostate cancer progression is disclosed. The method is useful for evaluating cells from patients at risk for recurrence of prostate cancer following sur..

A New Tumor Suppressor Gene

A new tumor suppressor gene, HIC-1, has been found. Abnormal DNA methylation of a CpG island, which includes this gene, was found in breast, brain, renal, lung, colon cancer and leukemias. In low-grad..

Staph-Enterotoxin B Receptor

Abstract (Set) We have discovered that a glycoshphingolipid ,digalactosylceramide serves as a receptor for SEB.And we have developed a recptor based immunoassay to detect n mole level of this toxin i..

A Novel Mutation Involved in Obesity and Type II Diabetes

A mutation has been found in the Beta3-adrenergic receptor gene, which is associated with obesity and non-insulin dependent diabetes mellitus (type II). The presence of the mutation indicates a suscep..

A Formulation of Anatomical Relationships in the Coronary Distribution of Non-calcified Plaque Based on Multi-detector CT Angiographic Assessment

Abstract (Set) Analyzing the data from coronary imaging of plaque is a complex process that makes it extremely difficult to compare any coronary plaque related information in a population-based study..

New Method of Collecting Exhaled Breath Biomarkers at Room Temperature

Abstract (Set) A simple method of collecting biomarkers that is fast, simple, and accurate is important for both research investigations and clinical management. There is currently limited number of ..

DNA Methylation for Diagnosic and Prognostic Determination in Prostate Cancer

Abstract (Set) Prostate cancer is the most commonly diagnosed cancer affecting men in the United States. Biochemical (PSA) recurrence of prostate cancer following radical prostatectomy remains a majo..

Alpha-Tocopherol Transport Protein: Compositions and Methods ( 95014)

Researchers at Northwestern have isolated the complete coding region of the human alpha-tocopherol transport protein.

A System and Method to Manage the Diagnosis and Therapy of Recurrent Urinary Tract Infections

Urinary tract infections (UTIs) account for more than 7 million outpatient visits to physicians' offices and well over one million hospital admissions in the United States annually. In ambulatory pati..

Selective, Facile, Quantitative Detection of Oxidized Abasic Lesions in DNA

Abstract (Set) A variety of structural modifications (lesions) are produced in DNA when the biopolymer is exposed to oxidative stress. Lesions can be genotoxic and/or cytotoxic, and are useful biomar..

Serial Assessment of Human Tumor Burdens in Mice by the Analysis of Circulating DNA

Abstract (Set) It is generally agreed that internal human xenografts provide the best animal models to study the microenvironments and metastatic processes occurring in human cancers. However, the us..

Biomarkers Differentially Expressed in Ovarian Cancer Cells with Deactivation of the MAPK Pathway

Abstract (Set) Activation of the MAPK signaling pathway has been implicated in many human cancers. Scientists at JHU have discovered that the expression profile of two biomarkers in the ovarian cance..

Methods and Use of Labeling Cells with X-ray and Ultrasound-visible Agents

Abstract (Set) Cell tracking has found major applications in immune and stern cell therapy. This is commonly done with MRI and MR contrast agents, radionuclide imaging agents, or positron emission to..

Head & Neck Squamous Cell Carcinoma an Non-Small Cell Lung Cancer Prognostics and Diagnostics

Abstract (Set) Epigenetic changes have been implicated in the pathogenesis of solid tumors and almost all types of cancers primarily via abnormal promoter hypermethylation and silencing of tumor supp..

Enzyme to Specifically Cleave Lys48-linked Polyubiquitin

Abstract (Set) A member of the deubiquitinating enzyme (DUB) family has been shown to associate with the ubiquitin E3 ligase GRAIL and to control GRAIL expression. Johns Hopkins researchers now show ..

Film Immobilized Capture-Particles

INVENTION: A new method of performing and analyzing protein-protein interactions, immuno-hybridization, and nucleic hybridization has been developed. This novel method utilizes capture particles immob..

Use of a Cellular Compartment as a Prognostic Marker of Breast Cancer

INVENTION: A cellular compartment (termed Cancer Compartment 1 or CC1) that is present predominantly in transformed cells and correlates with the degree of malignancy of breast cancer has been identif..

A Uniform Analysis Platform for Detection of Multiple Types of Cancer

INVENTION: A diagnostic tool capable of detecting multiple cancer types early in development from a single sample of blood. SIGNIFICANCE: The ability to detect and diagnose cancer early in its deve..

Biomarkers for Chronic Pelvic Pain Syndrome

INVENTION: Northwestern researchers identified MIP-1a and MCP-1 as biomarkers for Chronic Pelvic Pain Syndrome (CPPS). These markers are easily assayed from expressed prostatic secretions. These are t..

Self-immolative Magnetic Resonance Imaging Contrast Agents Sensitive to beta-glucuronidase

INVENTION: Northwestern researchers have created a Magnetic Resonance Imaging contrast agent providing a non-invasive diagnostic for necrotic tumors. The contrast agent is highly sensitive to the enzy..

Biomarkers for Pancreatic and Biliary Cancers

Abstract (Set) Pancreatic and biliary cancers are two of the most fatal among all human malignancies. Late presentation of the disease and lack of diagnostic markers are the major reasons for a disma..

Detection of Antibodies to Specific Glycans as a Novel Diagnostic Test for Autoimmune Disease

Abstract (Set) JHU scientists have identified biomarkers specific for autoimmune disease. Systemic autoimmune diseases are life- threatening, complex and can involve various organ systems including s..

Genomewide Analysis of Chromosomal Translocation

Abstract (Set) The cancer genome is quite unstable with many aberrant genetic translocations dispersed across its sequence. Many chromosomal translocations result in chimeric transcripts resulting in..

The Human C3b/C4b Receptor (CR1)

The present invention relates to the C3b/C4b receptor (CR1) gene and its encoded protein. The invention also relates to CR1 nucleic acid sequences and fragments thereof comprising 70 nucleotides and t..

MicroRNA-based Diagnostic Testing and Therapies for Inflammatory Bowel Disease

Ulcerative colitis (UC) and Crohn's disease (CD) are the two most common chronic inflammatory bowel diseases (IBD). They often share similar clinical characteristics, such as acute and chronic inflamm..

Identification of a Novel Vertebrate-specific chaperone, BBS12, That Causes Bardet-Biedl Syndrome

Bardet-Biedl syndrome (BBS) is an autosomal recessive disorder that occurs in approximately 1in 150,000 individuals. The syndrome is characterized by retinitis pigmentosa, polydactyly, obesity, mental..

Novel Drugs That Can Induce EBV Lytic Infection as a Potential Therapy for EBV Associated Tumor or To Assist in Diagnostic Imaging

Epstein Barr Virus (EBV) is a human gamma herpes virus that can establish either a latent or lytic infection in host cells. In its latent form, EBV is associated with a number of malignancies such as ..

Diagnostic Assays For a Polymorphism in a Gene That Affects Cardiovascular Health

High density lipoproteins (HDL) are considered good or healthy cholesterol that can protect against heart disease. However, there are people who have health problems despite having desirable levels of..

Near-infrared Fluorescent 6-0-glucosamine Compounds with Targeting Specificity to Lysosomes in Tumors

Optical imaging is a non-invasive, diagnostic imaging technology which can be used to inexpensively image pathological conditions with high sensitivity and low tissue irradiation. Technologies using ..

Alternative Splice Variant Patterns of Human Telomerase Reverse Transcriptase (hTERT) in Thyroid Tumors Distinguish Benign from Malignant

Human telomerase reverse transcriptase (hTERT) is activated in thyroid cancer. Despite this, its usefulness as a marker in the distinction of benign from malignant neoplasm has not been proven. hTERT ..

Method to Predict Severity of Inflammatory Central Nervous System Attacks by Detection of Interleukin-6 Levels

The present invention relates to soluble immune derangements in the cerebrospinal fluid of patients with autoimmune, inflammatory disorders of the central nervous system (CNS). Specifically, IL-6 is ..

ATR-Seckel Cancer Cells for Drug Discovery

Advanced gene targeting methods were used to generate biallelic knock-in point mutations in human colorectal cancer cells that cause a loss of ATR function, but retain enough activity to permit viabil..

Enhanced Novel Diagnostic and Prognostic Markers and Therapeutic Targets for Melanoma

Presently there are few effective systemic therapies to treat advanced stages of melanoma and the key to improved survival in all affected individuals remains early diagnosis and treatment. Scientists..

Diagnostic Screening for Disorders of the ER-to-Golgi Trafficking

This technology describes Cranio-lenticulo-sutural dysplasia (CLSD) as a novel autosomal recessive syndrome, and identifies a missense mutation in SEC23A segregating with this syndrome. SEC23A is an ..

Fabrication and Application of a Prokaryotic Proteome Chip

from E. coli, and the use of the purified proteins in the fabrication of a proteomic chip. This invention also relates to various methods of using the proteomic chip to identify protein factors which ..

HEYL, A Novel Oncogene

TGF-beta signal transduction is a primary tumor suppression pathway in breast cancer. Many breast cancer cells gain mechanisms to counteract the TGF-beta inhibitory effect but the mechanisms have rema..

Mycobacterial Catalase-peroxidase in the Diagnosis and Treatment of Sarcoidosis

Sarcoidosis is an organ-wide inflammatory disease of unknown etiology that is characterized by the presence of granulomas, and frequently, pulmonary dysfunction. Currently there are no definitive diag..

Chest Pain Differentiation Serum Diagnostic Panel (CPDP)

Abstract (Set) Patients presenting at an emergency room with acute chest pain are likely to be evaluated for acute coronary syndrome (ACS), pulmonary embolism (PE), aortic dissection (AD) and other l..

Identification of the Most Common Gene for Bardet-Biedl Syndrome

Bardet-Biedl syndrome (BBS) is characterized by multiple clinical phenotypes including retinal dystrophy, polydactyly, cognitive defects and retinal dysplasia. To date, nine BBS genes have been cloned..

Increasing the Depth and Breadth of Coverage of Sequences on a Microarray

Microarrays are used as an investigative tool for answering questions concerning DNA sequence and structure, gene expression, and the location of protein binding targets. Although microarray systems a..

COMPARE-MS: A Novel Technique for Rapid, Sensitive, And Accurate Detection of DNA Methylation

Hypermethylation of CpG island (CGI) sequences is a nearly universal somatic genome alteration in cancer. The rapid and sensitive detection of DNA hypermethylation can aid in cancer diagnosis and risk..

HIMF and related proteins in pulmonary, cardiac and inflammatory disorders

Hypoxia-Induced Mitogenic Factor (HIMF; also known as FIZZ1/RELM? a member of the resistin protein family, is a secreted protein that was found to be highly up regulated in the lungs as a result of h..

Genomic and Proteomic Biomarkers for Cystic Fibrosis

Cystic fibrosis is a common lethal genetic disease which is manifest by intrinsic hyperactivation of proinflammatory signaling pathways in the lung. However, the mechanism linking the CFTR mutation to..

Novel Imaging Agent to Detect Multidrug Resistance in Tumors Using Multimodality Imaging

Multidrug resistance (MDR) can develop during chemotherapy to desensitize tumors to a variety of structurally and functionally different chemotherapeutic agents and is linked to the expression of ATP ..

An Algorithm for the Discovery of Robust Protein Biomarkers with Application to the Design of Classification Protein Arrays

The application of high throughput proteomics to the discovery of protein expression patterns enabling accurate, sensitive and specific prediction of disease class and progression holds great promise...

Fluorescent 6-O-glucosamine compounds to label lysosomes in tumors in vivo and in cell culture systems for detection with optical imaging or fluorescence microscopy

Lysosomes contain numerous proteases, the release of which may play a vital role in breast cancer invasion and metastasis. Lysosomal trafficking may be an important factor affecting lysosomal enzyme ..

Imaging Methods for Assessment and Quantification of in vivo Antigen Capture and Vaccination

Abstract (Set) Immunization has eradicated many harmful infectious diseases in the Western world. This is commonly achieved by injecting individuals with attenuated pathogens such as viruses and bact..

A Multifunctional Intermediate for Imaging PSMA

The present invention includes a novel Prostate Specific Membrane Antigen (PSMA) intermediate. This molecule can be functionalized to become either a nuclear, optical, or magnetic resonance based imag..

Inversion Recovery with On-Resonant Water Suppression

JHU researchers have developed a new technology entitled, "IRON", which stands for Inversion Recovery ON-resonant water suppression. IRON is a magnetic resonance imaging (MRI) method that is designed ..

New Class of Reporter Genes for MRI Based on Chemical Exchange Saturation Transfer (CEST)

Among the clinically applied 3D imaging modalities, magnetic resonance (MR) imaging has the highest resolution and is therefore the preferred method for detection of cellular gene expression. However,..

Malaria Diagnosis in Urine

Scientists at JHU have developed a urine test for malaria, the first of its kind. The test will detect aldolase and pfhistidine-rich protein using an immunoassay design. The infectious agent, Plasmodi..

A High Throughput Screen Utilizing Newly Discovered Intramolecular Neuronal Calcium Channel interactions to Discover New Analgesics

This invention incorporates a newly discovered peptide which inhibits neural N-type calcium channels and the specific inter-molecular interaction that mediates the inhibitory effect of the peptide. Th..

Novel Diagnostic and Prognostic Markers, and Therapeutic Targets for Melanoma

The incidence of melanoma is increasing at the highest rate for any form of cancer in the United States and the current lifetime risk in the US is 1 in 68. Presently there are few effective systemic ..

Diagnostic Tool for Diagnosing Benign Versus Malignant Thyroid Lesions

Thyroid cancer represents 1% of all malignant diseases and it is estimated that 5-10% of the population will develop a clinically significant thyroid nodule during their lifetime. The best available t..

Microarray Gene Expression Profiling of IBD from Endoscopic Biopsy Tissues

This invention relates to the identification of biomarkers for ulcerative colitis (UC) and Crohn's disease (CD) and methods of screening. UC and CD are two highly prevalent inflammatory bowel diseases..

Nanowire Transport, Assembly, and Rotation in Suspension by AC Electric Fields

A variety of low dimensionality entities, such as nanospheres, nanodisks, nanowires, and nanotubes, have recently been explored due to their unique attributes and capabilities to bind chemical and bio..

Transgenic Frog Lines to Study Retina Degeneration

A JHU researcher has developed lines of transgenic frogs in which transgenes induce photoreceptor degeneration in vivo and can visibly reveal the viability status of the photoreceptors through a fluor..

PACE 4 Antisera and Cells

Rabbit antibodies against the proprotein processing enzyme PACE4; cell lines stably secreting PACE4

Method for the Detection of Schistosome Parasites

Schistosomes cause serious disease in humans and warm-blooded animals by living parasitically in the blood vessels draining the gut and bladder where they produce eggs that are passed out in the urine..

Monitoring Functional Kinetics of Vesicular Trafficking - Evidence for "Sleeping" Membrane Receptors on Cell Surface

The present inventive method is designed to measure the rate of protein trafficking to cell surface. Such measurement may be used to determine the physiological state of cells under different conditio..

Mutational analysis of the tyrosine phosphatome in colorectal cancers

JHU researchers have performed a comprehensive mutational analysis of the protein tyrosine phosphatases super gene family in colorectal tumors and other cancers. It was discovered that the mutated tyr..

Immune Modulation Through Targeting of the MINOR Gene

this gene will induce apoptosis in dendritic cells, thereby limiting immune responses. Inhibition of the gene will prevent dendritic cell death, thereby enhancing immune responses. Dendritic cells are..

Method and Kit for Diagnosis and Drug Screening Towards Psychiatric Disorders

This invention relates to a method and kit for diagnosis and drug screening towards psychiatric disorders. In particular, it provides as an example the utilization of the known molecular diversity of ..

Diagnostic and Prognostic Markers and Treatment Strategies for Multiple Sclerosis

To date, there are no definitive biomarkers to assist clinicians in the diagnosis of multiple sclerosis (MS) nor are there tools that accurately prodict the future clinical course of disease or the re..

A Method to Convert Single Base Changes to Large DNA Differences for Accurate and Sensitive Detection

In cancer and other human diseases, single-base mutations have an important role and can be used as markers for diagnostic tests. Unfortunately, in clinical samples small numbers of mutant cells are o..

A Transgenic Mouse Line Expressing Green Fluorescent Protein in Cells Containing Endogenous Notch Pathway Activation

The TNR1 mouse line (Transgenic Notch Reporter) contains exogenous DNA stably integrated into the genome. The transgenic sequence includes binding sites for a DNA binding protein CBF1 (also known as ..

Autonomous Ingestible Probe for Diagnosis and Therapy of Gastrointestinal Lesions Using Fluorescent Molecules

The invention is a Fluoropill (FP) - a swallowable pill-sized capsule camera for internal viewing of the digestive system and for transmitting video data to a reception system located outside the pati..

Registration of Ultrasound to Fluoroscopy (RUF)

The invention pertains to low dose-rate brachytherapy of early stage prostate cancer. It provides intra-operative fusion of ultrasound and X-ray fluoroscopy imagery, thus allows for real-time optimiza..

Widespread Requirement for Ligand-stimulated Hedgehog Pathway Activity in Growth of Digestive Tract Tumors

This work demonstrates that hedgehog (Hh) pathway activity plays a critical role in the growth of cancers derived from the gastrointestinal tract, including esophageal, pancreatic, biliary, and gastri..

Functionalized alpha 7 Nicotinic Receptor Ligands for Imaging

JHU researchers have synthesized a variety of new radiopharmaceuticals for imaging the a7 subtype of nicotinic cholingergic receptors. They are using nuclear medicine techniques, including positron em..

Using Wireless Electromyographic Data to Infer Hand Applied Forces

In an effort to quantify hand-applied forces without instrumentation of the object, we have developed a force measuring system that can wirelessly transmit force-related information to a data acquisit..

Direct Control of the Spatial Distribution and Arrays of Micro- or Nano-meter Scale Object Across Large Areas by Fluid Evaporation on Patterned Surfaces

Our technology combines two simple processing procedures: (1) patterning surfaces with regions of differing wettability, and (2) evaporating liquid droplets containing functional nano-objects or molec..

BRAF Mutation Occurs in a Majority of Papillary Thyroid Carcinoma

The BRAF gene was recently found to be activated by mutation in human cancers, predominantly in malignant melanoma. We tested a large number of primary tumors by PCR amplifications of BRAF exon 15 fol..

Treatment of Metastatic Colon Cancer with B-subunit of Shiga Toxin

Colorectal cancer is the second leading cause of death from cancer in the USA (Yokota, 2000). The high mortality associated with colorectal cancer is related to its ability to spread beyond the large ..

Apolipoprotein C-1 Induced Apoptosis

Apolipoprotein C-I, a small basic protein in human blood, induces apoptosis in cultured human arterial smooth muscle cells through the neutral sphingomyelin (N-SMase) pathway, and the subsequent seco..

Multiple Acquisitions of Magnetic Resonance Signal with Interleaved Inversion Pulses to Maintain the Nulling of One or More Species of Particular Longitudinal Relaxation Time(s) (T1)

In magnetic resonance imaging (MRI), one of the most common problems is to image a certain tissue without contamination from another one. For example, one is not interested in the signal coming from t..

Engineering RNAi Adenovirus Silencing Expression (ERASE) of DNA Repair Proteins

pERASE and Ad-ERASE (Engineered RNAi Adenovirus Silencing Expression) are respectively a plasmid and replication competent and/or deficient adenoviral vector-based systems encoding small inhibitory ri..

Combined Chemical/Biological Agent Detection by Mass Spectrometry

This is a mass spectrometer for combined chemical/biological agent detection and identification that comprises (a) a combined electron impact and MALDI ionization source for volatile and non-volatile ..

Design and Synthesis of Renal Dipeptidase Inhibitors

Colon cancer is a deadly disease with a 6% average lifetime risk in the United States. When detected in the earliest stages, patients have a 90% survival rate. In the early stages of colon cancer, how..

Non-linear Time-of-flight Mass Spectrometer

This is a unique approach to the design of time-of-flight mass spectrometers that utilizes non-linear electrostatic fields throughout the instrument. Specifically, the instrument does not include a fi..

A Nucleotide Factor Kappa-B Promoter Polymorphism is associated with Increased Risk For Ulcerative Colitis

We have been investigating genes that are associated with inflammatory bowel disease. Recently, we have identified a novel IBD risk polymorphism in a regulatory region of a gene that is associated wit..

Combined Chemical/Biological Agent Mass Spectrometer Detector

detection and identification of both chemical and biological agents. Specifically, it provides both conventional mass spectra of volatile chemicals and tandem, or MS/MS, measurements to characterize c..

Molecular Characteristics of Non-small Cell Lung Cancer

expression (SAGE) in a total of nine normal lung epithelial cells and non-small cell lung cancers (NSCLC). Separation of normal and tumor samples, as well as histopathological subtypes, was evident us..

Potential Biomarker for Use in Targeted Drug Delivery Applications As Well As Other Therapeutic Strategies

Abstract (Set) According to the World Health Organization (WHO), malignant tumors accounted for around 12% of deaths worldwide, and more than 10 million new cases of cancer emerge each year. JHU scie..

Magnetic Resonance Imaging and Spectroscopic Imaging of pH

In situ MR imaging and spectroscopy method to detect the effect of pH and/or protein content changes on the intensity of the water signal in MRI. This is done by selectively irradiating and saturating..

Use of Polymer-based Gene Delivery Systems For Molecular and Cellular Labeling, and pH Monitoring With MRI and MR Spectroscopy (MRS)

There is great interest in magnetic resonance imaging (MRI) contrast agents that are capable of visualizing small concentrations of molecular or cellular labels in vivo. The present invention relates ..

Ambulatory Raynaud's Monitor

Monitoring a person?s response to cold by recording their skin temperature is a key physiological response parameter for identifying Raynaud?s. This device would provide the means for physicians to de..

Simultaneous DNA Sequencing Technique (SimulSeq) and Combined PCR/sequencing (AmpliSeq)

We report two novel methods for DNA sequencing. AmpliSeq permits combined PCR and cycle sequencing in a single reaction. This can be bi-directional (e.g. for mutation confirmation) or unidirectional. ..

Beta-Secretase (BACE1) Polyclonal Antisera

To facilitate our understanding of the physiological role of BACE1 and its involvement in the generation of the Alzheimer?s disease (AD) Ab peptides, we generated a rabbit polyclonal antibody against ..

A Multiple-projection DXA Scanner for Improved Accuracy and Precision in the Measurement of Bone Cross-sectional Geometry and Body Composition

Osteoporosis and a number of other diseases and conditions alter the mechanical strength of the skeleton such that bones fracture easily. A number of treatments exist that can mitigate the loss of bon..

BDNF Polymorphism and Association with Bipolar Disorder

Methods for diagnosing and treating neuropsychiatric disorders, especially bipolar disorder, and to methods for identifying compounds for use in the diagnosis and treatment of neuropsychiatric disorde..

A Simulation Method for Designing Customized Interventional Medical Device During Pretreatment Planning

This invention, provides a method to design and evaluate the potential performance and/or clinical application of medical devices for interventional cardiovascular applications. The design and evaluat..

Simulator for cardiovascular Image Guided Therapy

An embedded and integrated system is disclosed for augmented reality based simulation of image-guided cardiovascular interventional therapeutic procedures for training, education and certification and..

MR Imaging of Vascular Gene Therapy

Our current knowledge about the bio-distribution and/or in vivo pharmacokinetics of gene therapy is incomplete and relies mainly on staining of biopsied or post-mortem tissues. Modern imaging techniqu..

Identification of DNA Sequences Differentially Methylated in Pancreatic Cancer

Researchers at Johns Hopkins University have used the techniques of methylated CpG island amplification (MCA) coupled with representational difference analysis (RDA) to isolate 42 clones, which were s..

The Cardiac Ausculatory Recording Database (CARD): an Internet-based software Program and Digital Heart Sound Recording Database for Teaching and Study of Cardiac Auscultation

The Cardiac Auscultatory Recording Database (CARD) was also developed. Developed using the Microsoft Access relational database program, CARD is available online through the World Wide Web. CARD conta..

Digital Optical Imaging for Tracking Vascular Gene Expression and Early Diagnosis of Atherosclerosis

Atherosclerotic cardiovascular disease remains the leading cause of mortality in the United States. Gene therapy is a rapidly expanding field with great potential for the treatment of atherosclerotic ..

A Novel Rapid Quantitative Assay for the Simultaneous Detection of Microbial Infection and Speciation

Current methods for determining whether a patient has a bacterial infection are time-consuming and may lead to delays in diagnosis and/or treatment. Real-time PCR is an emerging molecular technique, w..

Recombinant Ehrlichia Phagocytophila AnkA Protein (EPANK1 Protein) From Clone pHGE-D

Recombinant E. phagocytophilia MSP is a major immunodominant protein antigen derived from the human E. phagocytophilia (HE agent) strain BDS. The clone was initially selected based upon reactivity wit..

Rapid PCR-based blood test for Detection of Bacteria

An innovative technique that establishes a unique and highly specific assay, which eliminates ubiquitous background DNA in all PCR reagents (Taq polymerase, primers, dNTP's, PCR buffer, MgC12) by empl..

Near-field Radio Frequency Planar Strip Array Antenna for NMR Imaging

A device for detecting electromagnetic signals, more specifically, the magnetic resonance signals from excited nuclei as well as related apparatuses, systems and methods is provided. This detection de..

Bisubstrate Analog Inhibitors for Protein Kinases

A new approach for the design of protein kinase inhibitors is disclosed. Using this approach a potent insulin receptor protein tyrosine kinase inhibitor has been produced. In principle, this method is..

Referenceless Interleaved Echo Planar Imaging

The patent below describes a method for obtaining magnetic resonance images using ?echo planar imaging? and related techniques, without the use of ?reference scans?. The patent describes a method for ..

Methylated CpG Island Amplification (MCA)

Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation of tumor-suppressor genes in neoplasia. JHU scientists have developed a novel method of understandi..

FAMOUS: A Quantitative Assessment of Muscle Tone in the Wrist

This medical device is an automated robotic tone assessment device that non-invasively and properly quantifies tone of the flexor/extensor muscle groups that control the movement of an appendage such ..

EEG & Evoked Potential Digital Data & Programs

Experimental recordings of evoked potential signals have been digitized and stored on computer disks & CDs. Programs have been written to analyze and display the data and its subsequent interpretation..

A Method for Detection of Cancer and/or Risk of Cancer Based on Loss of Imprinting

At present, genetic testing is able to detect only a small fraction of the population at risk of cancer. For example, FAP mutations are present in less than 1% of the population, and hereditary nonpol..

Identification of the Human Fast-1 Gene

In Xenopus embryos, a subset of transcriptional responses to the TGF-B family of ligands is mediated by the Xenopus forkhead activin signal transducer-1 (xFAST-1). We have now identified a human FAST..

Passive Intraocular Pressure Sensors & Patient-Worn Monitorying Recorder

A device for passively measuring intraocular pressure of a patient including an in vivo sensor and an instrument external to the patient for remotely energizing the sensor, thereby permitting the inst..

GDF- 15

The present invention provides a growth and differentiation factor, GDF-15, and a polynucleotide sequence encoding GDF-15. In one embodiment, the invention provides a method for detection of a cell pr..

High Frequency Retrotransposition in Cultured Mammalian Cells

Two human L1 elements can actively retrotranspose in cultured mammalian cells. When stably expressed from an episome in HeLa cells, both elements retrotransposed into a variety of chromosomal location..

Method for Measuring Myocardial Motion

A method of magnetic resonance imaging of myocardial motion includes positioning a portion of a patient such as a patient's heart within a main magnetic field and employing a plurality of RF signals t..

A Test for the Diagnosis of Polycythemia Vera

Polycythemia vera (PV) is a stem cell disorder characterized as a panhyperplastic, malignant, and neoplastic marrow disorder. The most prominent feature of this disease is an elevated absolute red blo..

Novel Genes of Kaposi's Sarcoma Associated Herpesvirus (Human Herpesvirus Eight)

occurring in AIDS patients and closely associated with Karposi�s sarcoma (KS), body cavity based lymphomas (BCBL), multiple myeloma, and multicentric Castleman�s disease (MCD). JHU scientists have..

Use of Recombinant Bacteriophages to Monitor Ion Channel Receptor Expression im Mammalian Cells

The present invention concerns a novel method for detecting cell surface proteins utilizing a modified virus. This method combines peptide display technology and traditional immuno-amplification strat..

Discovery of Human Mad-related Genes

Resistance to the growth inhibitory effects of TGF-beta is common in human cancers. However the mechanism(s) by which tumour cells become restistant to TGF-beta are generally unknown. We have identifi..

Novel Peptide Modulators for NMDA Glutamate Receptor

The invention concerns the identification of a novel ligand binding site on a mammalian NMDA receptor. The invention further provides for NMDA receptor ligands, pharmaceutical compositions and novel d..

Method for Assessing Cardiac Contractility and Cardiovascular Interaction that may be Applied to Non-Invasive Clinical Practice

It has been found that E.sub.N (t.sub.N) curves are surprisingly similar among hearts, particularly during early contraction. Based on this observation, the present invention provides an arrangement (..

An Assay for Determining Subunit Interaction in Ion Channels

The present invention relates to compounds and related methods for both inhibiting and potentiating potassium ion channel activity. In particular, a molecular code of the alpha-subunit in a Shaker-lik..

Urease-Responsive Delivery Systems for Diagnostic and Therapeutic Applications

The present invention provides novel compositions and methods for diagnosing the presence of Helicobacter pylori infections of the stomach or duodenum in humans or other mammals. The invention provide..

DPC4, A Candidate Tumor-Suppressor Gene

The DPC4 gene is also known as SMAD4 or as MADH4. It is a mediator of signal transduction for TGFbeta, activin, bone morphogenic proteins, and similar extracellular growth and differentiation ligands...

Platelet Polymorphism PI-A2

A method for diagnosing a subject having or at risk of having a thrombotic disease syndrome is provided by analysis of a platelet polymorphism. Specifically, the association between polymorphism of th..

Cross-Linked Extra Cellular Matrix Polymers for Enzyme Detection

Proteoglycans are found throughout the body and serve numerous structural and functional roles. Chondroitin sulfate (CS) was modified to varying degrees with (meth)acrylate groups (CSMA) and polymeriz..

Cryo Filter Exchanger

This device maintains parallelism between diffracting crystals while allowing the crystals to continuously travel through high to low take-off angles. A central shaft that rotates by one half of the v..

Volatile Biomarkers for Analysis of Hepatic Disorders

The present invention features test systems and methods for detecting a hepatic disorder in a mammal and especially a primate. Preferred use of the invention involves staging the hepatic disorder in a..

Apparatus for the Separation of Cystic Parasite Forms from Water

A continuous flow centrifuge adapted with an insert of glass beads, sand or the like is used to concentrate cysts of microorganisms such as giardia or cryptosporidium from large volumes of water. The ..

Apparatus and Method for Exercising and Measuring Strength of a Patient's Limb

An apparatus for measuring the strength of and for performing physical therapy exercises to strengthen a patient's limb. The device includes a pair of pivot clamps each having a end for connecting the..

Monoclonal Antibodies (AE-1) Specific for Cytoskeletal Proteins useful for Tumor Diagnosis

Differential diagnosis of tumors can sometimes be difficult. For example, the histological appareance of thymoma (epithelial-derived) and histicytic lymphoma (mescenchyme-derived) can be similar. Sinc..

Mixing Cell for Microcalorimeters

The present invention relates to a device and method for measuring the heat of reaction resulting from the mixture of a plurality of liquid reagents. The heat of reaction is one of the most important..

Early Detection of Lung Cancer Treatment

The present invention relates to a method for early detection of lung cancer. The method comprises obtaining samples from the body, especially respiratory tract material including sputum or bronchial ..

Nuclear Magnetic Resonance Spectroscopy Data Acquisition Schemes for Phase-Sensitive Detection of Pure Absorption Mode Signals Devoid of Dispersive Components Arising from Phase Errors

The methodology described in this disclosure enables one, for the first time, to remove dispersive components arising from phase errors (inevitably) introduced during acquisition of multi-dimensional ..

Nuclear Magnetic Resonance Spectroscopy Methods for single Transient Data Acquisition without Use of Readout Pulsed Field Gradients

Nuclear Magnetic Resonance Spectroscopy Methods for single Transient Data Acquisition without Use of Readout Pulsed Field Gradients Categories: Research Tool, Diagnostic

Bridging Centrality: a Concept and Formula to Identify Bridging Nodes in Scale-free Networks

The invention relates to a novel essential component identification model, bridging centraility, based on information flow and topological locality in scale-free networks. Bridging centrality provides..

Aromatic Proton Relaxation Optimized Protein NMR Spectroscopy

In recent years, rapid NMR data collection has emerged as a pivotal area of research in structural biology. This invention describes the implementation of a longitudinal relaxation of aromatic protons..

G-Matrix Fourier transform NMR experiments for resonance assignment and structure determination of organic molecules

The suite of G-Matrix Fourier Transform experiements described can be used for complete resonance assignments of proteins and to obtain structural constraints for determining high resolution 3D struct..

A Rabbit Polyclonal Antibody Against Parkin

Since mutations of the parkin gene are the most frequent cause of familial Parkinson’s Disease (PD) and because heterozygous parkin mutations can also be found in sporadic PD, there is growing inter..

New GFT NMR Experiments for Complete Resonance Assignment of Proteins

This invention describes a set of new GFT NMR experiments for the assignment of backbone and side-chain resonances of proteins. The invention applies a Gaussian Matrix to the data acquisition and proc..

GFT NMR Spectra For Rapid Assignment and Secondary Structure Determination of Proteins

This invention describes the application of two previous inventions (5770 GFT NMR Spectroscopy and 5655 RD NMR Spectroscopy) to form a suite of four experiments. These improve measurement accuracy, as..

Phase Sensitively Detected Reduced-Dimensionality NMR Spectra For Rapid Assignment and Secondary Structure Determination of Proteins

UB researchers have developed a novel NMR data acquisition and processing scheme named GFT nuclear magnetic resonance (NMR) Spectroscopy, where ‘GFT’ stands for a combined G-matrix and Fourier tra..

GFT NMR Spectroscopy

The minimal measurement time of an N dimensional FT NMR experiment is constrained by the need to sample N-1 indirect dimensions and may therefore exceed by far the time required to achieve workable si..

CT Mammography Detector

Computed tomography (CT) uses x-ray imaging to obtain cross-sectional images of the body that can then be integrated into a three dimensional image. Unlike conventional x-rays, CT scans can distinguis..

Single frame laser scan ratio imaging using two wavelength excitation

For two distinct chromophore populations to be imaged and their ratio computed, currently two different laser excitations are raster scanned and alternately switched after each frame of data acquisiti..

Thermal Imaging at micrometer resolution

Thermal imaging (visual reproduction of thermal gradients within a body) is a mature science. Several instruments exist that are variants of infra-red (IR) radiation detection cameras. But with IR wav..

Region of Interest Micro-Angiography

In cerebro-vascular interventions, smaller and smaller catheters, guide wires, and interventional devices such as stents and coils are being used which are difficult to visualize with conventional ima..

CryoTissue Conditioner (Conditioner Solution for Frozen Tissue Sections for Histological Examination)

Microscopic examination of tissue morphology and intracellular protein content is one of the major methods of assessing disease states in tissue samples. Current techniques often result in damage to t..

A Method to Distinguish Organisms Causing Exacerbations of Chronic Bronchitis

The invention provides a simple, quick and inexpensive test for discriminating between bacterial and non-bacterial exacerbations of chronic lung disease. The test is based on the strong correlation be..

Novel and Enhanced approaches to determine local mRNA accessibility for Development of Post-Transcriptional Gene Silencing Agents

Bioinformatics approach for determining mRNA sites which are good candidates for RNAi or ribozyme sites. Categories: Genomics, Diagnostic

Identification of Lead Candidate Ribozymes for Human Rod Opsin Therapeutics

Highly effective hammerhead ribozyme sequenes for reducing rod opsin mRNA levels. Categories: Genomics, Diagnostic

High Throughput Cellular Screening for Development of Post-Transcriptonal Gene Silencing Agents against Arbitrary mRNA Targets

High Throughput Cellular Screening for Development of Post-Transcriptonal Gene Silencing Agents against Arbitrary mRNA Targets SEAP-based HTP screening method for ribozyme sites on mRNA targets. ..

Nuclear Magnetic Resonance Spectroscopy Data Acquisition Schemes for Phase-Sensitive Detection of Pure Absorption Mode Signals Devoid of Dispersive Components Arising from Phase Errors

Nuclear Magnetic Resonance Spectroscopy Methods for single Transient Data Acquisition without Use of Readout Pulsed Field Gradients

Nuclear Magnetic Resonance Spectroscopy Methods for single Transient Data Acquisition without Use of Readout Pulsed Field Gradients Categories: Research Tool, Diagnostic

Novel and Enhanced approaches to determine local mRNA accessibility for Development of Post-Transcriptional Gene Silencing Agents

Bioinformatics approach for determining mRNA sites which are good candidates for RNAi or ribozyme sites. Categories: Genomics, Diagnostic

High Throughput Cellular Screening for Development of Post-Transcriptonal Gene Silencing Agents against Arbitrary mRNA Targets

SEAP-based HTP screening method for ribozyme sites on mRNA targets. Categories: Genomics, Diagnostic

Use of RNA inhibitors based on IL-14 and antibodies to IL-14 for the treatment of autoimmune diseases and lymphomas

Autoimmune disorders and B cell derived lymphomas cause life-long suffering or premature death. Often the treatment for these diseases is symptomatic at best with severe side effects. An effective new..

Non-Invasive Screening Device for Upper Aerodigestive Tract Neoplasia

Diagnostic medical equipments are probably one of the most important paraphernalias of the medical field. This is because of the fact that in all the medical procedures, diagnosis is the first step to..

Aromatic Proton Relaxation Optimized Protein NMR Spectroscopy

CT Mammography Detector

CryoTissue Conditioner (Conditioner Solution for Frozen Tissue Sections for Histological Examination)

G-Matrix Fourier transform NMR experiments for resonance assignment and structure determination of organic molecules

Use of anti-T antibody to block metastasis of T antigen bearing tumors

Many cancer cells contain a carbohydrate structure on their surface known as the Thomsen-Friedenreich Antigen (TF-Ag). This antigen, which is not detectable on normal cells, plays a pivotal role in me..

Single frame laser scan ratio imaging using two wavelength excitation

Thermal Imaging at micrometer resolution

Holographic formation of periodic polymeric photonic bandgap structures for visible to IR wavelengths

Chemical and biological sensor developers have held an interest in nanoscale construction of periodic structures. Numerous optical fiber products that utilize nanoscale periodic etching are available ..

Monoclonal antibody 3F5-5E5 and P107 diagnostic markers and putative vaccine antigen for Moraxella catarrhalis and supplemental Mab 4G5

This invention includes monoclonal antibodies, proteins, nucleic acid seqeunces and lipoologosaccharides (LOS) which are specific to Moraxella catarrhalis. These materials are useful for designing a m..

New GFT NMR Experiments for Complete Resonance Assignment of Proteins

Research Reagents for Human Serum Paraoxonase Status

PON1 is a glycoprotein that plays a role in both metabolism of organophosphate pesticides and in the cardioprotective effect of high-density lipoprotein (HDL). Two mutant forms of the protein are know..

GFT NMR Spectra For Rapid Assignment and Secondary Structure Determination of Proteins

Phase Sensitively Detected Reduced-Dimensionality NMR Spectra For Rapid Assignment and Secondary Structure Determination of Proteins

GFT NMR Spectroscopy

A Method to Distinguish Organisms Causing Exacerbations of Chronic Bronchitis

Region of Interest Micro-Angiography

HIV antisense ORF(s) and putative protein(s)

The current invention is a gene comprising an open reading frame on the plus strand of the pro-viral DNA, and located in the region of HIV-1 long terminal repeat. The gene encodes a protein that is re..

OUTER MEMBRANE PROTEIN B1 OF MORAXELLA CATARRHALIS

The present invention includes a method for the isolation and purification of outer membrane protein B1 as well as B1 peptides from Moraxella catarrhalis, and the resulting compositions. The method in..

Detection of Porphyromonas Gingivalis

This invention is an accurate and sensitive system to detect the presence of Porphyromonas gingivalis, a bacterial strain associated with the development of periodontal disease. The bacteria are detec..

Non-Invasive Screening Device for Upper Aerodigestive Tract Neoplasia

Holographic formation of periodic polymeric photonic bandgap structures for visible to IR wavelengths

Use of RNA inhibitors based on IL-14 and antibodies to IL-14 for the treatment of autoimmune diseases and lymphomas

Use of anti-T antibody to block metastasis of T antigen bearing tumors

Monoclonal antibody 3F5-5E5 and P107 diagnostic markers and putative vaccine antigen for Moraxella catarrhalis and supplemental Mab 4G5

OUTER MEMBRANE PROTEIN B1 OF MORAXELLA CATARRHALIS

Respiratory Detection System (RDS)

Introduction Respiration rates are an important indicator of cellular and metabolic states in cells ranging from mammalian to bacterial, from individuals to large populations. Unfortunately, conventio..

Surface-Bound Double-Stranded DNA Protein Arrays

Summary Developed at Harvard Medical School, this invention provides nucleic acid arrays specifically designed for the assay of DNA-dependent protein:protein binding and/or physical interactions betwe..

Microfluidic Arrays for Multiplex Detection of Analyts

Summary This invention is a microfluidic array apparatus and a method of performing multiple analyses on multiple samples simultaneously, utilizing nanoliter volumes of reagents. It has two embodiment..

MicroArray Spot LINEar Regression (MASLINER) software

Summary Signal intensities between samples on a microarrary typically vary by as much as three to four orders of magnitude, frustrating efforts at comparative analysis of samples assayed in parallel. ..

Multiplexing long DNA syntheses

Summary The invention enables multiplex gene synthesis in a single reaction, using very low concentrations of oligonucleotides. The method, which employs a unique temporary tagging strategy, offers si..

Label-free Detection of Small Molecule-Protein Interactions using Nanowire Nanosensors

Summary This invention describes a method of detecting and quantifying competitive inhibition of a co-factor or substrate binding to an enzyme (or other biological binding partner) utilizing very smal..

A Microconcentrator and Microfilter for Suspensions such as Blood

Summary Background: In healthcare, chemical analysis, environmental testing and other fields it is useful to separate particulate substances that are suspended in a fluid. For example separating ce..

Torque-Actuated Valves for Microfluidics

Summary Background: A number of active and passive valves for microfludic systems, based on bubbles, pneumatics, electrokinetic, and other mechanical solutions, have been developed. So far these so..

A microfluidic differential manometer for cellular-scale hydrodynamics

Summary Background: The development and application of microfluidic systems have increased dramatically in recent years. The systems that typically involve controlled fluid flow through a number of..

Synthetic trivalent haptens that form stable bicyclic trimeric complexes with anti-hapten antibodies -- a platform technology for developing new diagnostics and therapeutics

Summary Markets/Needs Addressed: The detection or modulation of the activity of antibodies in vivo and in vitro is important for a wide range of diagnostic and therapeutic applications. However, the ..

Targeting FtsZ Activity Using Novel Antibacterials: Screening Assays, Small Molecule Hits, and Synthetic Pathways to Potent Natural Products

Summary The emergence of bacterial strains resistant to current drugs has prompted a renewed effort to discover new methods for fighting infectious disease. A promising new target is FtsZ, a key media..

Synthetic trivalent haptens that form stable bicyclic trimeric complexes with anti-hapten antibodies -- a platform technology for developing new diagnostics and therapeutics

Multiplexed, Elecatrical Detection of Cancer Markers Using Nanowire Sensor Arrays

Summary Semiconductor nanowire field effect transistors were modified using surface chemistry to create real-time, multiplexed and label-free sensor arrays for detecting a variety of biological specie..

A microfluidic differential manometer for cellular-scale hydrodynamics

Background: The development and application of microfluidic systems have increased dramatically in recent years. The systems that typically involve controlled fluid flow through a number of microfl..

Use of Cytokine IP-10 as an Anti-Tumor Agent

Summary The invention provides compositions and methods for the diagnosis and treatment of both malignant and benign cell-proliferative diseases. When complexed to its receptor, IP-10 interacts with k..

Probe of Regional Lung Function

Summary This invention provides a direct means for measuring the dynamic properties of small regions of the lung of a living animal in real time. The parameters of lung function which may be analyzed ..

Home-Based Monitoring Addressing High-Risk Cardiovascular Conditions and Sleep Apnea

Summary Sleep may trigger a variety of adverse conditions in patients with heart and/or respiratory ailments. While numerous sleep apnea monitors have been developed, a critical unmet need exists for ..

Production and uses of polymerase colony ("polony") arrays

Summary The invention provides methods for rapid fabrication and use of replicable, high-density nucleic acid arrays. Array features are produced through amplification on a support matrix of nucleic a..

Surface-Bound Double-Stranded DNA Protein Arrays

A Tool for the Linkage and Presentation of Multiple Protein Functional Domains

Summary Recent molecular biology research is moving beyond genetics to look at protein - protein interactions and how cells interact or communicate. These exciting areas are in need of improved tools ..

Vaccine Compositions AMPERSAND Methods for Human Papilloma Virus

Summary This invention comprises methods of expressing the Human Papilloma Virus L1 and L2 proteins, and variations thereof, in bacterial host cells; the purification of the expressed proteins; and th..

Valpha24JalphaQ Receptor: Lead Diagnostic and Therapeutic for Type I Diabetes

Summary Background: Autoimmune diseases are the result of a patient's immune system attacking their own cells and tissues. This can result in a wide variety of diseases, including multiple sclerosis, ..

Use of glycated CD59 levels to assess glycemic control in diabetic patients

Summary The invention enables rapid detection of impaired glucose tolerance (IGT, or â€œpre-diabetesâ€) without oral glucose tolerance testing and permits identification of a population at ri..

Single-Cell Transcriptional Analysis with Microarrays

Summary The enormous tissue and cellular diversity of multicellular organisms poses unique challenges, such as learning the gene expression patterns associated with embryonic or neurological developme..

Next Generation Diagnostics for Breast Cancer, Prostate Cancer, and Melanoma

Summary From the labs of Professor Alun Jones (inventor of CardioliteTM) and Professor Ashfaq Mahmood, comes a series of small molecule imaging probes, capable of conjugation to both SPECT-based and P..

A Versatile Method for Accelerated Chromosome Walking and DNA Fingerprinting

Summary Background: A variety of DNA amplification methods deal with sequence analysis of an uncharacterized region adjacent to a known element. These methods include inverse PCR (iPCR), panhandle PCR..

Microcapillary Column Peptide Trap

Summary Protein detection using liquid chromatography (LC) followed by tandem mass spectroscopy has become a valuable tool for large-scale proteome analysis. Many efforts have been made to enhance thr..

Microfluidic Arrays for Multiplex Detection of Analyts

Algorithm for Haplotype Construction of Single Nucleotide Polymorphism

Summary The Haplotyper software program utilizes a novel algorithm called Partition-Ligation to reconstruct individual haplotype phase information from unphased genoptype data. The Partition-Ligation ..

Susceptibility to Tuberculosis 1 (sst1): Novel Target for Diagnosis and Treatment of Mycobacterium tuberculosis

Summary Background: Tuberculosis is the seventh most important cause of global premature mortality and disability. Currently there are 8 million new cases and 3 million deaths annually from tuberculos..

Multiplexing long DNA syntheses

Bead-based polymerase colony microarrays and nucleic acid sequencing ("Polony-FISSEQ Beads")

Summary Foundational work of Dr. George Church has enabled the production and use of replicable arrays of polymerase-amplified nucleic acid colonies (so-called "polonies") on semisolid support matrice..

Amplification of trace amounts of nucleic acids

Summary The importance of nucleic acid amplification from trace amounts of biological sample has increased with the expansion of genomic sequencing in various clinical and research-oriented applicatio..

Label-free Detection of Small Molecule-Protein Interactions using Nanowire Nanosensors

Fully-integrated 2D microelectromagnet coil arrays in silicon for magnetic manipulation and RF imaging of cells and magnetic particles

Summary The invention comprises a novel method and an apparatus to manipulate, segregate, detect and analyze biological samples on a microfluidic CMOS chip. This technique offers sub-micrometer precis..

A Microconcentrator and Microfilter for Suspensions such as Blood

Background: In healthcare, chemical analysis, environmental testing and other fields it is useful to separate particulate substances that are suspended in a fluid. For example separating cells from..

Torque-Actuated Valves for Microfluidics

Summary Background: A number of active and passive valves for microfludic systems, based on bubbles, pneumatics, electrokinetic, and other mechanical solutions, have been developed. So far these so..

Mass spectrometric methods of determining levels of glycated CD59

Summary CD59 is a protein that exists in both glycated and non-glycated forms. An elevated ratio of glycated to non-glycated CD59 has been found to be an early (i.e., pre-symptomatic) prognostic marke..

Multiplexed, Elecatrical Detection of Cancer Markers Using Nanowire Sensor Arrays

Proteasome-Mediated Degradation of RISC: Lead Target for Treatment of Long-Term Memory Disorders

Summary Background: Breakthrough research by Professor Sam Kunes and colleagues at Harvard University demonstrates that degradative control of the miRNA RISC pathway underlies the synaptic pattern of ..

Detection of Invasive Bladder Cancer by DNA Hypermethylation

Summary Background: The National Cancer Institute has estimated that in year 2008, 68,810 new cases of bladder cancer will be diagnosed in United States, causing 14,100 deaths. The mortality of this c..

A microfluidic differential manometer for cellular-scale hydrodynamics

Summary Background: The development and application of microfluidic systems have increased dramatically in recent years. The systems that typically involve controlled fluid flow through a number of..

Targeting FtsZ Activity Using Novel Antibacterials: Screening Assays, Small Molecule Hits, and Synthetic Pathways to Potent Natural Products

Enhanced Nanoparticle-Based Molecular Imaging via MRI

Summary Enhanced Nanoparticle-Based Molecular Imaging via MRI Elevator pitch: For biotech and pharmaceutical companies who need to track drug effectiveness in the drug discovery and for MRI facili..

Novel Biomarkers for Chronic Myelogenous Leukemia (CML)

Summary A high-dimensional metabolomics screen to diagnose and monitor chronic myeloid leukemia (CML) has been developed. Over 3000 metabolites are detected to yield a â€˜cytogenetic signatureâ�..

A Novel Screening Method for Assessment of Psychopathologic Disorders

Summary Background: The advancement in psychiatric genetics and clinical neuroscience is hindered by the heterogeneity of psychiatric disorders and by difficulties in defining and characterizing the p..

Identification of Contactins and L1-CAMs as ligands for the Amyloid Precursor Protein

Summary Approximately 24 million people worldwide have dementia of which the majority (~60%) is due to Alzheimerâ€™s; by 2040, it is projected that this figure will have increased to 81 million. ..

Synthetic trivalent haptens that form stable bicyclic trimeric complexes with anti-hapten antibodies -- a platform technology for developing new diagnostics and therapeutics

Combinatorial Allelic Anaalysis via Multiplex Automaged Genome Engineering ("MAGE")

Summary Applications Contact Maryanne Fenerjian, PhD Office of Technology Development Tel: 617-432-3845 Email: maryanne_fenerjian@harvard.edu For Further Information Please Contact the Director of..

Compounds and Methods for Tumor-Specific Targeting

Summary A novel strategy for developing cancer-homing drugs has been developed by Dr. Amin Kassis that combines Enzyme-Mediated Cancer Imaging and Therapy (EMCIT) with radionuclides (see figure below)..

Biological Computers: In Vivo Autonomous Doctors that Diagnose and Treat Disease

Summary Background: The promise of computers made from biological molecules lies in their potential to operate within the biochemical environment of a living organism and to interact with that environ..

C16:1n7-palmitoleate: A novel lipid hormone as a diagnostic and therapeutic tool

Summary Markets / Needs Addressed: Insulin resistance is the key factor of a collection of metabolic disorders including Type II diabetes, atherosclerosis, fatty liver disease, hypertension and dyslip..

Torque-Actuated Valves for Microfluidics

Summary Background: A number of active and passive valves for microfludic systems, based on bubbles, pneumatics, electrokinetic, and other mechanical solutions, have been developed. So far these so..

A microfluidic differential manometer for cellular-scale hydrodynamics

Summary Background: The development and application of microfluidic systems have increased dramatically in recent years. The systems that typically involve controlled fluid flow through a number of..

Biological Computers: In Vivo Autonomous Doctors that Diagnose and Treat Disease

Fully-integrated 2D microelectromagnet coil arrays in silicon for magnetic manipulation and RF imaging of cells and magnetic particles

Home-Based Monitoring Addressing High-Risk Cardiovascular Conditions and Sleep Apnea

rocapillary Column Peptide Trap

MicroArray Spot LINEar Regression (MASLINER) software

Fully-integrated 2D microelectromagnet coil arrays in silicon for magnetic manipulation and RF imaging of cells and magnetic particles

Torque-Actuated Valves for Microfluidics

Summary Background: A number of active and passive valves for microfludic systems, based on bubbles, pneumatics, electrokinetic, and other mechanical solutions, have been developed. So far these so..

Multiplexed, Elecatrical Detection of Cancer Markers Using Nanowire Sensor Arrays

A microfluidic differential manometer for cellular-scale hydrodynamics

Summary Background: The development and application of microfluidic systems have increased dramatically in recent years. The systems that typically involve controlled fluid flow through a number of..

A Novel Screening Method for Assessment of Psychopathologic Disorders

Biological Computers: In Vivo Autonomous Doctors that Diagnose and Treat Disease

A microfluidic differential manometer for cellular-scale hydrodynamics

Summary Background: The development and application of microfluidic systems have increased dramatically in recent years. The systems that typically involve controlled fluid flow through a number of..

Next Generation Diagnostics for Breast Cancer, Prostate Cancer, and Melanoma

Genetic Test for Periodontal Disease

Summary Peridontitis is a serious oral disease characterized by highly painful loss of tissue between the tooth and the gingival tissue. In the US, it is estimated that dentists perform upwards of 28...

Detection of Invasive Bladder Cancer by DNA Hypermethylation

Novel Biomarkers for Chronic Myelogenous Leukemia (CML)

C16:1n7-palmitoleate: A novel lipid hormone as a diagnostic and therapeutic tool

Microfluidic Arrays for Multiplex Detection of Analyts

Multiplexing long DNA syntheses

A microfluidic differential manometer for cellular-scale hydrodynamics

Summary Background: The development and application of microfluidic systems have increased dramatically in recent years. The systems that typically involve controlled fluid flow through a number of..

Identification of Contactins and L1-CAMs as ligands for the Amyloid Precursor Protein

Mediators of Chronic Allograft Rejection and DNA Molecules Encoding Them

Summary This invention provides methods of detecting and treating arterial inflammatory disease, including chronic allograft rejection subsequent to organ transplantation or chronic vascular Chlamydia..

NF-X1: Novel Target for Inhibition of MHC Class II Transcription and Autoimmune Disease

Summary The class II MHC molecules function in the presentation of processed peptides to helper T cells during an immune response. Dysregulated expression of class II major histocompatibility complex ..

Eotaxin: an Eosinophil Chemoattractant

Summary Investigators at Harvard Medical School have isolated and functionally characterized eotaxin, a novel mammalian chemokine that regulates migration of eosinophils, a class of leukocytes known t..

A Strain of the Ehrlichial Agent

Summary The NCH-1 strain of the agent of human granulocytic ehrlichiosis (HGE), isolated from a Nantucket patient in 1994, is available as a continuous culture in HL60 promyelocytic leukemia cells. Th..

Surface-Bound Double-Stranded DNA Protein Arrays

Identification of a Sequence Element from p53 that Signals for Mdm2-targeted Deg

Summary Research at Harvard University has led to a novel means of protecting the cell against oncogenic tumor formation. This invention provides compositions and methods for inhibiting degradation of..

Single-Cell Transcriptional Analysis with Microarrays

Aminoglycosides Scaffolding Targeting Antibiotic-Resistant Bacteria

Summary This invention encompasses key modifications to the chemistry of aminoglycosides to overcome bacterial resistance. The novel chemistry leverages: (a) the weak stereospecificity of aminoglycosi..

Targeting FtsZ Activity Using Novel Antibacterials: Screening Assays, Small Molecule Hits, and Synthetic Pathways to Potent Natural Products

Summary Inhibition of bacterial septation machinery represents a promising approach for countering antibiotic-resistant bacteria. One such approach targets FtsZ, an essential protein and key mediator ..

A Novel Class of Phospholipase A2 Preferentially Expressed in Th2 Cells

Summary This invention describes the identification of a novel, low molecular weight class of Phospholipase A2 enzyme, PLA2 Group XII, that is involved in Type 2 T helper (Th2) cell differentiation an..

Time and concentration warping software for RNA and protein expression data

Summary The predominant strategies for drug discovery today employ high-throughput screens and microarray-based methods that generate large data sets. Increasingly, these techniques are being used to ..

A Drug Discovery Platform Using Novel Labeled Uridine Analogs: Unique moieties contribute to molecular biology research

Summary Background: Uracil is a nucleic acid base that, when bound to ribose or deoxyribose, forms uridine or deoxyuridine, respectively. Certain analogs of uridine and deoxyuridine have been synthesi..

A Versatile Method for Accelerated Chromosome Walking and DNA Fingerprinting

Microcapillary Column Peptide Trap

TreeDock protein docking software

Summary Predicting protein-protein and protein-ligand docking remains one of the challenging topics of structural biology. The main problems are (i) to reliably estimate the binding free energies of d..

HDAC Inhibitors

HDAC Inhibitors Laura Brass Email: laura_brass@harvard.edu Telephone: (617) 495-3067

Absolute Quantification of Proteins (AQUA)

Summary This invention provides methods, reagents and kits for obtaining absolute quantification of proteins and their modifications directly from cell lysates. In particular, the invention provides p..

Algorithm for Haplotype Construction of Single Nucleotide Polymorphism

Tome-1, a novel cell-cycle gene required for mitotic entry

Summary This invention, out of Marc Kirschner's research group, concerns the discovery of a novel protein required for mititic entry. Harvard researchers have isolated and identified the protein and t..

Saframycin Assay

Summary Background: Chemotherapeutic DNA-binding compounds exert their effects, in part, by preventing DNA synthesis and initiating events that leads to apoptotic death. Despite the excellent antiprol..

Susceptibility to Tuberculosis 1 (sst1): Novel Target for Diagnosis and Treatment of Mycobacterium tuberculosis

Multiplexing long DNA syntheses

Bead-based polymerase colony microarrays and nucleic acid sequencing ("Polony-FISSEQ Beads")

Novel Candidates for Tuberculosis Therapy

Summary There is a need for new antibiotics that are useful against tuberculosis. Proteasomes of Mycobacterium tuberculosium are essential in enabling these bacteria to evade killing by macrophages of..

Amplification of trace amounts of nucleic acids

Label-free Detection of Small Molecule-Protein Interactions using Nanowire Nanosensors

Genetic Test for Periodontal Disease

Targeting FtsZ Activity Using Novel Antibacterials: Screening Assays, Small Molecule Hits, and Synthetic Pathways to Potent Natural Products

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