Access Teams of Expert Solvers led by World-Class Facilitators

Seeking to Innovate?

Accelerate your company's innovation capacity
[CONTACT US]

INNOVATION RESOURCES

Life Sciences Technologies for Sale or License

The following are Life Sciences technologies offered for sale or license. Viewing technologies for sale is a free service of IdeaConnection.com, as is connecting with the seller if a technology interests you. Click on a heading below for more information.

Life Science is the study of biological systems and how they interact with their environment. Life Sciences involve the study of living creatures and microbes. Post your life science technology for sale or license here.

TOBACCO-BASED NICOTINE AEROSOL GENERATION SYSTEM

The invention relates to devices and methods for delivering nicotine and/or other alkaloids from tobacco, other plants and other natural sources. More particularly, the invention relates to devices an..

NEUROACTIVE STEROID COMPOSITIONS AND METHODS OF USE FOR LOWERING CHOLESTEROL

Methods for ameliorating a symptom associated with hypercholesterolemia, hyperlipidemia, or both in a subject. In some embodiments, the methods include administering to a subject in need thereof an ef..

COMPOSITIONS AND METHODS FOR THE TREATMENT OF DRUG-INDUCED HAND-FOOT SYNDROME

The present invention provides methods of treating, ameliorating or preventing hand-foot syndrome in a subject in need thereof comprising administering to the subject a therapeutically effective amoun..

Use of SH2 STAT3/STAT1 Peptidomimetics as Anticancer Drugs

The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics th..

NIOSOME-HYDROGEL DRUG DELIVERY SYSTEM

Localized drug delivery systems are effective means to administer therapeutic concentrations and controlled release of drugs. A delivery system consisting of non-ionic surfactant vesicles (niosomes) p..

DRUG DELIVERY DEVICE FOR OVARIAN CANCER

A drug delivery device has been designed to directly deliver an agent to the ovaries through direct contact with the fallopian tubes. The device consists of three main components: a tubular inserter, ..

PROGNOSTIC TOOLS TO PREDICT THE EFFICACY OF DRUG TREATMENT TARGETING CHROMATIN DNA OR ENZYMES ACTING ON DNA

Disclosed are methods of predicting cell response to drug-based therapy using both PCR-Stop assays and real time PCR assays. Methods herein may be used for assessment of drug effect, evaluation of reg..

Aqueous sustained-release drug delivery system for highly water-soluble electrolytic drugs

The present invention relates to liquid sustained release suspension dosage forms comprising ionized forms of water-soluble drugs. In particular, the invention encompasses a liquid form controlled rel..

CARBOHYDRATE FUNCTIONALIZED CATANIONIC SURFACTANT VESICLES FOR DRUG DELIVERY

Carbohydrate functionalized catanionic vesicles that include a glycoconjugate and/or peptidoconjugate for vaccination or drug delivery, methods for forming these, and methods of using these.

DELIVERY OF THERAPEUTIC AGENTS USING OLIGONUCLEOTIDE-MODIFIED NANOPARTICLES AS CARRIERS

Disclosed are drug delivery compositions comprising an oligonucleotide-modified nanoparticle and a therapeutic agent. Specifically, disclosed are compositions comprising a number of oligonucleotide mo..

POTENT COMBINATIONS OF ZIDOVUDINE AND DRUGS THAT SELECT FOR THE K65R MUTATION IN THE HIV POLYMERASE.

Combinations of antiretroviral nucleoside reverse transcriptase inhibitors, and methods for their use in treating retroviral infections, are provided. In one embodiment, the combinations include non-t..

DRUG CONJUGATES

Conjugated compounds comprising a therapeutic or diagnostic agent linked to a substrate for a cell membrane transporter or receptor by lipophilic linker are provided.

APTAMER-MEDIATED DRUG RELEASE

The present invention relates to aptamer/drug conjugate complexes and the use of such complexes, together with a trigger compound, to inducibly release a drug. Through these complexes, the present inv..

MODULATION OF PHOSPHOLIPASE D FOR THE TREATMENT OF THE ACUTE AND CHRONIC EFFECTS OF ETHANOL

The present invention relates to methods of decreasing the negative effects of alcohol on behavior as well as inhibiting the toxic effects of alcohol, comprising administering, to a subject, an effect..

ANTI-DRUG VACCINES

The present invention relates to anti-drug vaccines based on conjugates between the drug and a non-immunogenic carrier protein. In preferred embodiments, it provides for anti-cocaine vaccines and thei..

METHODS, DEVICES, AND SYSTEMS FOR ON-DEMAND ULTRASOUND-TRIGGERED DRUG DELIVERY

Injectable or implantable drug delivery systems providing on-demand ultrasound- triggered drug release and methods for controlling the release of drug in a patient are provided herein. The on-demand d..

Novel anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof

The present invention provides methods for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject. The present invention further provides methods for treating and preventin..

NOVEL ANTI-ARRYTHMIC AND HEART FAILURE DRUGS THAT TARGET THE LEAK IN THE RYANODINE RECEPTOR (RYR2)

The present invention provides novel 1,4-benzothiazepine intermediates and derivatives, methods for synthesizing same, and methods for assaying same. The present invention also provides methods for us..

IMPROVED CANCER DRUG DELIVERY USING MODIFIED TRANSFERRIN

The invention provides modified Transferrin (Tf) molecules and conjugates of the Tf molecules with a therapeutic agent. The invention also provides methods of treating cancer wherein the therapeutic a..

METHOD OF ENGINEERING POLAR DRUG PARTICLES WITH SURFACE-TRAPPED HYDROFLUOROALKANE-PHILES

The invention relates to a method of engineering polar drug particles with surface-trapped hydrofluoroalkane-philes.

PROCESS FOR IDENTIFYING DRUGS FOR TREATING GASTROESOPHAGEAL REFLUX

Methods for identifying modulators of gastroesophageal smooth muscle relaxation include isolating various types of smooth muscle fibers from the stomach or esophagus and inducing the fibers to contrac..

MICROSPHERE/NANOFIBER COMPOSITES FOR DELIVERY OF DRUGS, GROWTH FACTORS, AND OTHER AGENTS

Provided are compositions that include polymeric fibers and microspheres entrapped within the fibers, the compositions being capable of controlled delivery of one or more agents while also maintaining..

Reservoir device for intraocular drug delivery

A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of th..

USE OF HIGH-DOSE OXAZAPHOSPHORINE DRUGS FOR TREATING IMMUNE DISORDERS

This disclosure relates, at least in part, to methods of eliminating adverse immune reactions in a subject in need thereof including those associated with autoimmune diseases, allergic reactions and t..

CULLEN 5 AS A REGULATOR OF HSP90 CLIENTS: A NEW TARGET FOR DRUG DEVELOPMENT

Cullin5 (Cul5) E3 ubiquitin ligase is shown to be linked with the heat shock protein 90 (Hsp90) chaperone complex. Hsp90 participates in the folding of its client proteins into their functional confor..

METHOD FOR IMPROVED BIOACTIVATION OF MEDICATIONS

The invention relates to a prodrug comprising a partial structure having the general formula (I) or (II), where R1 and R2 are hydrogen, alkyl, or aryl radicals.

DEGRADABLE HYDROGEL COMPOSITIONS AND METHODS

This invention concerns an in situ biodegradable hydrogel drug delivery system in which the components are assembled in a manner that provides a mechanism for the timed cleavage of a particular amide ..

POLYARYLATES FOR DRUG DELIVERY AND TISSUE ENGINEERING

Biocompatible polyarylates of diphenol compounds and poly(alkylene oxide) dicarboxylic acids, articles formed therefrom and therapeutic uses are disclosed.

COMPOSITIONS AND METHODS FOR TREATING OPHTHALMIC DISEASES.

Degradable polymeric compositions containing water-insoluble drugs blended with copolymers of biocompatible diphenol compound monomer units with pendant carboxylic acid groups polymerized with biocomp..

RECONSTITUTED TUMOR MICROENVIRONMENT FOR ANTICANCER DRUG DEVELOPMENT

Extracellular matrix bioscaffolds capable of supporting the formation and growth of tumors from tumor cells introduced thereto containing tumor associated macrophages and carcinoma-associated fibrobla..

METHOD FOR TREATING AND/OR PREVENTING DRUG SEEKING BEHAVIOR

A dynorphin-A analog can be used for treatment, inhibition, and/or prevention of cocaine seeking behavior, and or the drug seeking behavior for a cocaine derivative or other structurally related subst..

METHODS FOR SCREENING FOR ANTIBIOTIC COMPOUNDS

The present invention is a method for screening drugs for antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell.

COMPLIANT COMPOSITES FOR APPLICATION OF DRUG-ELUTING COATINGS TO TISSUE SURFACES

A compliant composite for delivering a bioactive agent including a scaffolding material and a polymer coating that together can be attached to compliant tissue surfaces is disclosed, along with method..

POLYESTERS WITH GRAFTED ZWITTERIONS

The invention relates to polymers, such as aliphatic polyesters, with grafted zwitterions More particularly, the invention relates to polyester-graft-phosphorylcholine polymers prepared by ring-openin..

Drug delivery product and methods

The present invention provides a particulate delivery system comprising an extracted yeast cell wall comprising beta-glucan, a payload molecule and a payload trapping molecule. The invention further p..

METHOD FOR DETERMINING THE SUSCEPTIBILITY OF A CELL STRAIN TO DRUGS

The present invention relates to a method for determining the susceptibility of a cell strain to a compound intended for controlling the growth of said cell strain, comprising: - growing the cell stra..

IGF1 FOR MYOCARDIAL REPAIR

Provided herein are methods for treating an individual having (suffering from) an acute myocardial infarction and drug eluting stents useful for treating such individuals. These methods include treati..

METHOD OF IDENTIFYING INDIVIDUALS AT RISK OF THIOPURINE DRUG RESISTANCE AND INTOLERANCE

The invention relates to methods and kits for identifying individuals at risk of thiopurine drug intolerance based on detecting the presence of mutations in the TPMT gene promoter associated with thio..

A1 ADENOSINE RECEPTOR ALLOSTERIC ENHANCERS

The present invention relates generally to chemical compounds and methods for their use and preparation. In particular, the invention relates to chemical compounds which may possess useful therapeutic..

THERAPY AND PREVENTION OF PROBLEM DRINKING

The present invention provides methods for the therapy and prevention of problem drinking in alcohol-dependent and non-dependent subjects and those at risk of developing problem drinking behavior, and..

SYNTHETIC, SELF ADJUVANTING VACCINES

The present invention relates generally to the field of immunotherapy, and more particularly to immunomedicaments in the form of lipopeptides which induce an antibody response to drugs of dependence, ..

METHOD OF ELICITING OR INDUCING AN IMMUNE RESPONSE

A method for eliciting or inducing an immune response in a human or animal subject, comprises administering to said subject a composition comprising an antigen and an adjuvant, wherein the composition..

THERAPEUTIC APPLICATIONS

The specification relates to methods for treating a neurodegenerative disease such as multiple sclerosis by administering to a subject in need an EphA4 antagonist or an EphA4 ligand antagonist. The an..

THERAPEUTIC USE

PROBLEM TO BE SOLVED: To provide a method for treating neurodegenerative diseases such as multiple sclerosis by administering an EphA4 antagonist or an EphA4 ligand antagonist to a subject in need. ; ..

MONITORING SYSTEM FOR MICRONEEDLE DRUG DELIVERY

The invention relates to a microneedle drug monitoring system, and also a microneedle device when provided with the drug monitoring system, comprising the selective and sequential coating of microneed..

THERAPEUTIC PEPTIDES

Therapeutic peptides derived from the extracellular region of human Toll-like receptor 2 (TLR2) are useful in the treatment of acute and chronic inflammatory conditions.

METHOD FOR CONTROLLING THE ALERTNESS OF A HUMAN SUBJECT AND A LIGHT SOURCE FOR USE IN THIS METHOD

The invention relates to a method for controlling the alertness of a human subject and a light source for use in this method and use of a light source for this method. The method comprises exposure of..

THERAPEUTIC PEPTIDES, POLYPEPTIDES ANS NUCLEIC ACID SEQUENCES

Described are isolated peptides (GLGGGDLSV, SLNESQIKI, LMLPAVLQA and FTAEQLQRL) derived from portions of the Engrailed-2 (EN2) protein. Also described is their use in therapy, in particular in relatio..

THERAPEUTIC ARYL-AM I DO-ARYL COMPOUNDS AND THEIR USE

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-amido-aryl compounds of the following formula (for convenience, collectively refer..

APPARATUS AND METHOD FOR INFLUENCING FISH SWIMMING BEHAVIOUR

An enclosure, method and apparatus for influencing the swimming behaviour of fish is disclosed. The enclosure defining a space within which the fish can swim, said enclosure having a series of light o..

PROBE FOR DETECTING A PARTICULAR NUCLEIC ACID SEQUENCE

The invention relates to a detection molecule (triplex Molecular Beacon, tMB) for detecting a particular nucleic acid sequence, in particular for detecting a single nucleotide mismatch in a target nuc..

HXR9 peptide acting to block HOX / PBX binding

The HOX genes are a family of homeodomain-containing transcription factors that determine the indetitity of cells and tissues during embryonic development, and are also known to be deregulated in a nu..

Method and Technology of Production of Echogenic Microbubbles Combining Properties of Drug Carriers and Ultrasound Contrast Agents

In the present invention, echogenic drug-loaded microbubbles are generated from stable micro- or nanoemulsions of perfluorocarbon upon injection into the body. This invention enables users to control ..

Covalent Tethers for Isolating Homogeneous Proteins

Recent advances in technology have led to methods for generating large sets of genomic and proteomic samples. This has created a need for tools that facilitate rapid screening and analysis of these l..

Generation of Ribozyme Libraries

Antisense technology provides a platform for drug discovery as well as clinical therapeutic applications. Antisense agents (such as DNA, RNA, and ribozymes) bind to complementary regions on host nucl..

Diagnostic Test for Equine Hyperelastosis Cutis

The present invention provides a method of diagnosing equine hyperelastosis cutis (HC), an inherited connective tissue disorder of increasing prevalence in Quarter Horses. The diagnostic test include..

Treatment of Mucocillary Clearance in Cystic Fibrosis Patients and Respiratory Inflammation by Using Alkylaryl Polyether Alcohol Polymers

The present invention provides a novel method to use alkylaryl polyether alcohol polymers as antioxidants to block oxidant reactions and prevent tissue injury and disease that are related to overprodu..

Method of Treating Cancer, Particularly Malignant Melanoma, Using Dithiocarbamate Derivatives

Dithiocarbarmate, particularly tetraethylthiuram disulfide, strongly inhibits the growth of a variety of cancer cells. The present invention provides a novel strategy for treating cancer, particularly..

Activating c-kit mutation in melanoma and other cancers - therapeutic and prognostic significance

In cancer treatment, a better understanding of the specific genetic and molecular changes that contribute to tumor growth is leading to the development of targeted therapies, which are predicted to be..

Methods for Identifying Chromosomal Aneuploidy

Proper DNA dosage is essential for normal and cellular development and function. Molecular approaches for the detection of chromosomal abnormalities will allow the development of rapid, cost-effect..

Graded Regulation of Protein Activity

Much of biological activity is regulated through posttranslational protein modification in response to various stimuli. Proteins involved in cell proliferation, survival, migration, and shape can be ..

Novel Compound to Specifically Stimulate Erythropoietin (EPO) Production for Improved Red Blood Cell Count

This invention discloses an approach whereby the administration of a synthetic organic compound specifically induces proliferation of erythropoietin-producing peritubular interstitial cells in the kid..

Method of Analyzing Dicarboxylic Acids

This invention describes a method for the high throughput qualitative and quantitative analysis of dicarboxylic acids, and in particular methylmalonic acid (MMA), which exploits the high specificity o..

Novel Bioassay and Cell Lines for Direct Bioassay of Androgenic Activity and Steroid Hormone Levels

The present technology provides novel engineered Saccharomyces cerevisiae (yeast) cell lines which are useful in bioassays for the identification and measurement of steroid hormone bioactivity in huma..

Conantokins: peptides with antiseizure and analgesic activity

This invention pertains to conantokins, a subset of peptides isolated from cone snail venom. Conantokins are selective NMDA receptor antagonists that hold promise as antiseizure and analgesic therapie..

The APC Gene, for Detection and Diagnosis of Inherited and Sporadic Colorectal Cancers

The adenomatous polyposis coli (APC) gene is a tumor suppressor gene which is altered in many colon cancers. Germline mutations of APC are the cause of familial adenomatous polyposis (FAP), an inherit..

MCC Gene - Mutated in Colorectal Cancer

The MCC gene is in close linkage with the adematotous polyposis coli (APC) gene on chromosome 5q21, a region of frequent loss of heterozygosity in colon cancer. MCC is found to be mutated in some col..

Suppressing Proliferation of Melanoma Cells by Inhibiting NAD(P)H Oxidase From Producing Reactive Oxygen Species

The present invention provides a method for suppressing malignant melanoma proliferation by inhibiting NAD(P)H oxidase enzymes from generating reactive oxygen species (ROS). Malignant melanoma cells ..

Methods for Improved Selection of Oligo-Probes for Array Design

Uses of high throughput genomic technologies, including microarray technologies, are growing exponentially. One major limitation of current array technology is the poor predictability of hybridizatio..

Therapeutic Target and Screening Method for Inhibitors of Platelet Activation and Coagulation

Platelets are specialized blood cells that function in the formation of blood clots, and these cells act as the key cellular effectors of thrombosis. Tissue Factor (TF) is an essential cofactor for..

Molecular Diagnostic Method for Detection of Platelet Activation- Prognostic Significance for Sepsis and Venous Thromboembolism

Platelets are specialized blood cells that function in the formation of blood clots, and these cells act as the key cellular effectors of thrombosis. This work demonstrates that Cdc2-like kinase 1 ..

DNA Methylation As a Target for Prognosis and Treatment of Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL), has the greatest prevalence rate among all leukemias. A significant limitation of both the existing staging systems for CLL is that they do not allow for reliable p..

A Mouse Model of Synovial Sarcoma

The present invention provides the first and only genetic mouse model of synovial sarcoma, a highly aggressive, malignant childhood/young adult soft tissue cancer. This mouse model was generated by co..

Novel Anti-Reductive Strategies for the Treatment of Heart Failure, Diabetes Mellitus and Degenerative Diseases

Though oxidative stress is widely implicated in pathogenic states including aging and heart failure, the role of reductive stress, which is defined as the abnormal increase of reducing equivalents (e...

Predicting Prostate Cancer Resistance to Hormonal Treatment by Measuring Serum Concentrations of Chromogranin A

Continued progression of prostate cancer during endocrine therapy is a major clinical problem. Hormonal treatment resistance and development of metastasis during the treatment have been linked to neur..

Nematode Neuromuscular Junction GABA Receptors and Related Methods

The major inhibitory neurotransmitter in the brain is ?-aminobutyric acid (GABA), which primarily acts through GABAA receptors. Defective GABA neurotransmission causes neurological diseases such as a..

Method for Obtaining an Enriched Population of siRNA-Expressing Cells Useful in Gene Therapy

The invention relates to a method of enriching a population of mammalian cells having an RNA interference (RNAi) sequence by providing eukaryotic (e.g., mammalian) cells containing a target gene. The..

Convenient, Accurate Methods of Molecular Haplotyping Using Hybridization Probes and Long-Range PCR

Genetic research has shown that variation or polymorphism in a gene may cause disease, increase risk of disease or affect response to therapeutic treatment of the disease. The particular combination o..

Prodrugs and Conjugates of Thiol- and Selenol-Containing Compounds to Treat Cancer and Radiation Exposure

Providing selenium in a nontoxic form is a distinct challenge. Organic forms appear to be superior to inorganic ones. This technology discloses a method for the design, synthesis and evaluation of p..

Pestalotiopsis Microspora Isolates and Compounds Derived Therefrom

Endophytic fungi and bacteria are those organisms living within the tissues of host plants. Typically, endophytes coexist with their hosts without any pathogenic symptoms. These organisms have proven..

A Rapid and Sensitive Assay to Measure Hepcidin Levels in Biological Fluids

Hepcidin is a liver-produced peptide hormone which controls iron absorption by regulating the amount of the cell surface iron transporter ferroportin, which exports iron from cells to blood. Altered ..

O-glycosylated peptides, including Contulakin G, with therapeutic potential for treatment of pain and seizure

This technology comprises O-glycosylated cyclic peptides, including contulakin- G and derivatives isolated from cone snail venom. These show promise as therapeutics for pain, seizures, and other indic..

Potent Protease-Resistant Inhibitors of HIV Entry, a Novel Compound for Treatment of AIDS

The present invention provides a new family of potent D-peptide inhibitors of HIV entry. These inhibitors have several advantages over Fuzeon, the only FDA-approved HIV entry inhibitor that is current..

Unc-74 Gene Encodes a Novel Transmembrane Thioredoxin Domain Containing Protein, which Is Required for Acetylcholine Receptor Formation

Ligand-gated ion channels are multimeric protein complexes, whose function depends on precise and correct ordered assembly of individual subunits. Using the nematode C. elegans as a model system for ..

In-vitro Production of Natural Killer (NK) Cells and Creation of Immortalized NK Cell Lines

Natural Killer (NK) cells provide early defense against pathogens several days before the adaptive immune responses become operational. They are a type of lymphocyte responsible for destroying viruse..

Designed Antigens to Elicit Neutralizing Antibodies against the HIV-1 gp41 N-Trimer Region to Prevent HIV Entry into the Host Cell

HIV protects its conserved entry machinery with a steric block, preventing the binding of most antibodies. The present invention provides the methods of producing and identifying sterically restricte..

New Model for Nicotinic Acetylcholine Receptors

Signal transduction within and between cells mean that they can communicate important information and act upon it. Aberrant signal transduction is the cause of many of the most personally and financi..

New Methods and Targets for Modulating Odor Sensitivity in Olfactory Epithelium

This invention demonstrates that purine nucleotides and dopamine modulate the odor sensitivity of peripheral olfactory receptor neurons (ORNs). Located in the dorsal recesses of the nasal cavity, the..

Induction of Apoptosis by HIV Viral Protein, a New Target for Treatment of AIDS and Cancer

Since its discovery in the early 1980s, infection with HIV has reached epidemic proportions, especially in developing countries. Estimates suggest that 42 million people are living with HIV/AIDS worl..

A Rapid Method for in vivo Synthesis of Large Libraries of Cyclic Peptides

Dr. Eric Schmidt and colleagues at the University of Utah have found a novel method to synthesize large libraries of amide-linked, modified cyclic peptides by expression of constructs in Escherichia c..

Novel Continuous Solvent Extraction Without Moving Parts

Solvent extraction is an efficient method for selectively removing, purifying and concentrating certain elements or compounds from a solution because the solutes can be selectively removed and they ca..

PCR System for Real-time Quantification of Samples

This invention comprises a nucleic acid quantification kit and method for determining the initial concentration or mass fraction of a target nucleic acid present in a sample. More particularly, the i..

A New Immune System for the Immune Compromised

The Technology The process of T cell development, from stem cell to mature T cell, consists of a series of commitment events and multiple developmental checkpoints that are controlled by a se..

Dual-Sided Microchannel Plate Detector Mount for Coaxial Time-of-Flight Mass Spectrometers

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland Security and the medical community lead the list. Current instruments ..

METHOD FOR SYNTHESIZING NOVEL FURANOSTEROIDS

The furanosteroids are a class of pentacyclic fungal metabolites that share in common a furan ring bridging positions 4 and 6 of the steroid skeleton. Members of this class are known for their powerfu..

IDENTIFICATION AND USES OF IRON AND OTHER DIVALENT CATIONS TRANSPORTERS

Iron deficiency afflicts over 3 billion people worldwide, and plants are the principal source of iron in most diets. In response to iron deficiency, all plants except the grasses induce Fe(III) chela..

IDENTIFICATION AND USES OF A NOVEL IRON TRANSPORTER

Iron is an essential nutrient for all higher plants, with iron-containing compounds figuring prominently in the electron transport systems of photosynthesis and respiration. Although iron is abundant..

IDENTIFICATION AND DISCOVERY OF A NEW FAMILY OF METAL TRANSPORT GENES WHICH CAN BE USED FOR TOXIC METALS REMOVAL

Pollution of the environment is one of the major problems facing the modern world. Removal of toxic metals poses particularly difficult problems, as unlike organic pollutants they cannot be biodegrad..

INEXPENSIVE PROCESS FOR SEPARATION AND MASS PRODUCTION OF CELLODEXTRINS

Cellodextrins (-1,4-glucose oligomers) are of interest for investigating cellulase hydrolysis mechanisms and kinetics. In addition, cellodextrins have been used to investigate aspects of microbial ..

NOVEL METHOD FOR PREVENTING OR TREATING MOTION SICKNESS

Motion sickness has been a long-standing problem for travelers, aviators and sailors. For some people, motion sickness symptoms can ruin a trip or even be disabling. Common remedies taken to prevent s..

NOVEL METHOD FOR PRODUCING THIONO DERIVATIVES USEFUL IN DRUG SYNTHESIS

Thionation, the conversion of a carbonyl group to the corresponding thiocarbonyl group, is a standard method for the preparation of a variety of useful organosulfur derivatives, including thionoesters..

Thermostable Purified Endoglucanases from Thermophilic Bacterium Acidothermus Cellulyticius

Technology Description A substantially purified high molecular weight cellulase enzyme having a molecular weight of between about 156,000 to about 203,400 daltons isolated from the bacterium Acido..

Targeted Nanoscale System for Combined Therapy and Imaging of Cancer

Background Cancer is the second leading cause of death in the United States. As the number of diagnosed cancer patients increases, there is growing need for improved treatment strategies and imaging t..

Surface Functionalization of Polymers for Drug Delivery

Background Currently, wet chemical conjugation and simple adhesion are used to achieve surface functionalization of biodegradable polymer particles. Unfortunately, both of these methods have poor repr..

Silver Nanoparticles for Antibacterial and Antiviral Applications

Background The use of antibacterial agents is widespread and can be seen in many products ranging from cosmetics to household cleaners. All tend to rely on alcohol- or triclosan-based ingredients to e..

Rose-Shaped Gold and Iron Oxide Nano Structures and Their Applications: Tissue Imaging Contrast Enhancement, Medical Diagnostics, and Photothermal Therapy

Background The identification and treatment of many life-threatening diseases such as cancer, heart disease, and atherosclerosis depends on the outputs provided by innovative medical imaging technolog..

Molecular Specific Photoacoustic Imaging and Photothermal Therapy

Background Despite enhanced understanding and the development of new therapeutic options, cancer remains a major cause of human morbidity and mortality worldwide. Early diagnosis of malignant events i..

Method for Fabricating Arrayed Light Emitting Probes for a Scanning Optical Microscope

The resolution of conventional (far-field) optical microscopes is limited by diffraction to the wavelength of light. The near-field scanning optical microscope (NSOM), a recent advancement, obtains hi..

Metallic Nanoparticles Directly Functionalized with Protein, Synthesized by Chemical Reduction in Aqueous Solution

Background While there are many ways to synthesize nanoparticles, most have proven hard to solvate. Minor temperature flux can cause nanoparticles to drop out of solution, and current methods yield so..

Injectable, Disease-Responsive Nanocontainers

Background Current drug delivery technologies rely on diffusion/degradation and are neither targeted nor stimuli-responsive. Further, several MEMS-based drug delivery devices have been formulated, but..

Improved Nanosurgical Efficacy Through Plasmonic Laser Ablation

Background There is widespread optimism that nanosurgery will allow the improved resection of diseased tissues with minimal invasiveness and lessened collateral damage to adjacent healthy tissues. Ini..

Improved Method for Production of Highly Uniform Nanoparticles for Drug Delivery

Background Nanoparticles have multiple applications in tissue targeted drug delivery, non-invasive monitoring of therapeutics, and as delivery devices. They also can be used by the cosmetics, agricult..

Improved Method for Production of Highly Uniform Nanoparticles for Drug Delivery

Glycerin Based Synthesis of Nanoparticles and Nanowires

Background Currently, there is a rising problem of antibiotic resistance due to certain bacteria exhibiting immunity. Also, there are no completely efficient treatments or vaccines to prevent or treat..

Biodegradable MicroSpheres for Drug and Vaccine Delivery

Background Immunizations are an essential tool in the prevention of many infectious diseases. DNA vaccines offer great promise for safer and more effective vaccines when compared to traditional protei..

Antiviral Properties of Silver Nanoparticles

Background Current bioconjugates seem to be very unstable in the resulting product, which is a problem in creating a well-rounded nanoparticle. There is currently a need for a better process to inhibi..

Prevention of Anthrax Infection with Anthrax Antibody Fragments

Background Current treatments for persons exposed to anthrax spores rely heavily on antibiotics to prevent the growth and ensuing toxicity of the anthrax bacteria; however, these treatments could be c..

Targeted Modification of Genomes with Lactococcus Lactis Ll.LtrB Group II Intron (TARGETRON)

Background Functional genomic disciplines seek to understand the contributions of genes and their protein products in healthy and disease conditions. Due to evolutionary conservation, model organisms ..

Robert M. Krug

Novel Molecular Target for Influenza Virus Antiviral Development

Background Influenza A viruses cause a highly contagious respiratory disease in humans that causes a significant loss of life each year, and dramatic mortality rates during human pandemics. H5N1 avian..

Methods for the Production of Recombinant Proteins with Multiple Disulfide Bonds in E. Coli

Background Currently, there is no way to produce complex eukaryotic proteins with multiple disulfide bonds in bacteria. This is because the bacteria cannot normally form the correct disulfide bonds in..

Method for Pre-Determining and Reversing Toxicity of Drugs

Background Side effects and toxicity are a significant issue with many promising drugs. While a drug may remedy the targeted illness, serious side effects can, in some cases, be worse than the initial..

Method for biological removal of sulfites from alcoholic beverages and food

Background Sulfite hypersensitivity is an important problem for millions of people. Furthermore, a number of disorders in humans have been proven to be associated with allergic responses to sulfite. S..

Membrane for the production of oxygen enriched air

Background Many elderly and sick people require oxygen-enriched air to facilitate breathing. Unfortunately, oxygen tanks are heavy and need to be refilled, limiting their convenience. Further, portabl..

Laser Treatment of Cutaneous Vascular Lesions

Background Coagulate vessels often need multiple treatments before they can be destroyed. Current technologies are limited by the finite penetration depth of light and by the natural flow characterist..

Influenza Inhibitors

Background The Centers for Disease Control and Prevention estimates that up to 20% of Americans contract influenza each year during flu season. Although most recover, it is estimated that 100,000 of t..

G-Quadruplex-Interactive Compounds as Possible Anticancer Agents

Background There have been few dramatic therapeutic breakthroughs in cancer research. Many more anticancer drugs are in use today than ever before, but nearly all of these drugs are severely limited i..

Chemical Modification of Polysaccharides for Efficient Delivery of RNA and DNA Therapeutics

Background Nucleic acid-based therapeutics are rapidly becoming the next generation of drugs, offering promising potential for a variety of diseases. Antisense and small interfering RNAs (siRNA) "knoc..

A G-Quadruplex DNA Cleaving Compound and Novel DNA-Cleaving Antitumor Agents

Background There have been few dramatic therapeutic breakthroughs in cancer research. More anticancer drugs are in use today than ever before, but nearly all of these drugs are severely limited in the..

Software to Record Auditory Event-Related Potentials

Background Existing software that acquires event-related potentials from human subjects is mostly custom written by the user and not commercially available. Those that are commercially available only ..

Micro-electro-mechanically Tunable Nano-photonic Grating Displacement Sensor

Background Sensors represent a billion-dollar market characterized by eleven product segments. Two of the sensor product segments are: 1. Proximity and displacement sensors and 2. Force and load senso..

Methods for Expressing RNP Particles in Eukaryotic Cells

Gene Targeting in Eukaryotic Cells by Purified Group II Introns

Background Functional genomic disciplines seek to understand the contributions of genes and their protein products in both healthy and disease conditions. Due to evolutionary conservation, model organ..

Enhancing the Production of Complex Proteins in Bacteria

Background Numerous therapeutic proteins contain disulfide bonds. However, the production of proteins containing multiple disulfide linkages in genetically engineered bacteria is very inefficient. Bac..

Assays for Identifying Functional Alterations in the p53 Tumor Suppressor

Background The p53 gene is mutated in over half of all tumors, indicating its importance in the process of carcinogenesis. The gene encodes a tumor suppressing transcription factor that binds to certa..

Anchored Periplasmic Expression (APEx): A Powerful Technology for Antibody Discovery and Combinatorial Protein Library Screening

Invention Description APEx is a validated method to isolate binding polypeptides, including antibodies or antibody fragments, that recognize specific molecular targets. A library of polypeptide (e.g.,..

A Rapid Colorimetric Assay for Drug Discovery

Background The FDA currently requires pharmaceutical firms to create enantiomerically pure substances, or that the enantiomer of the drug be thoroughly studied and found to have no adverse side effect..

A Portable Vector Maximizing Protein Expression in High-Density Bacterial Cultures Using Either Temperature or Chemical Induction

Background Bacterial fermentation remains a popular and reliable form of protein production for both research and commercial applications. Current systems require complementary functional elements pre..

Real-Time Imaging and Monitoring of Laser-Tissue Interaction

Background In laser dermatological and oncology treatments, absorbed radiant energy generates an increase in temperature to heat targeted structures. However, before performing laser therapy, it is im..

Photoacoustic Imaging for Early Detection of Cardiovascular Plaque

Background Almost 81 million individuals in the United States suffer from a form of cardiovascular disease that cost over $400 billion yearly in the United States alone. Coronary heart disease is the ..

Improved Nanosurgical Efficacy Through Plasmonic Laser Ablation

Cell Arrays for Measuring Gene Function on a Genomic Scale

Background Even with the completion of the human genome sequence, the functions and interactions of most encoded genes have yet to be uncovered. Understanding the role of genes and gene networks under..

A Solid Biodegradable Device for Use in Tissue Repair

Background Conventional methods for tissue repair involve sutures, staples, or clips. By their very nature, they result in a "foreign body" being left in the tissue. Tissue injury and foreign body rea..

A Miniaturized Optical System for Combined Multiphoton Endoscopy and Ultrashort-Pulse Laser Micro-Nanosurgery

Background According to the American Cancer Society, approximately 2.5 million cases of cancer were diagnosed in the US in 2007 (including basal and squamous cell epithelial cancers), of which 85% ori..

Three-Dimensional Fabrication of Bioelectronic Interfaces

Background Bioelectronic interfaces hold great promise for medicine and research; however, current fabrication methods for electronic or electroactive materials typically involve expensive lithographi..

Secretion of Folded Recombinant Proteins for Enhancing the Production of Complex Proteins in Bacteria

Background Bacteria are a common source of recombinant proteins for a variety of research, therapeutic, and vaccine applications. Recombinant proteins accumulating intracellularly often form insoluble..

Porous biopolymer hydrogels prepared by in situ crystallization

Background Organ failure and tissue loss account for half the medical spending in the United States. In theory, transplantation is the last therapeutic option available to people in the final stage of..

Patterned Dual Crosslinked Biopolymer Hydrogels

Background Approximately eight million surgical procedures are performed annually in the United States to treat tissue damage resulting from accidents, birth defects, hereditary disorders, and other d..

Novel Membrane Materials and Methods for Gas Separation

Background Current methods for CO2 removal are not only very expensive but also cause large losses of gas and the use toxic chemicals. Furthermore, most polymer membranes used for purification are mor..

Method for Identifying Novel Telomerase Inhibitors with Utility in Cancer Treatment

Background Certain sequences of DNA are able to form unique, G-quadruplex structures. These structures are implicated in a variety of biological processes. One example of such a process is the cancer-..

Improved Production of S-Adenosyl Methionine for Nutraceutical Applications

Background A major drawback to the use of SAM as a medicament is its expense: present methods of production rely on the chemical transformation of methionine, which is an expensive starting material. ..

Method for Improved Synthesis of Steroid Hormone Precursors

Background The current method used to convert a,ß unsaturated ketones into a hydroxy ketones or a hydroxy esters results in only moderate selectivity with a low yield. Also, the effectiveness of some..

A Novel Preparation of Pyrroles from Nitriles and Cyclopropanes

Background The new use of known materials to prepare pyrroles in a highly efficient and selective manner is the nature of the discovery. Invention Description A new method for the synthesis of pyr..

3-Dimensional Bioconstruction Techniques to Connect Electronic and Biological Systems

Background Bioelectronic interfaces hold great promise for medicine and research; however, current fabrication methods of electronic or electroactive materials involve expensive lithographic masks, co..

System for Site-Specific, Controlled, On-Demand Drug Delivery

Background Current controlled-release drug delivery technologies rely on diffusion/degradation, and are not physiologically responsive. Several MEMS-based drug delivery devices have been formulated, b..

Surface Functionalization of Polymers for Drug Delivery

Ricin Inhibitors and Methods for Use Thereof

Background Ricin is a potent heterodimeric cytotoxin easily isolated from the seeds of the castor plant, Ricinus communis. The protein consists of a lectin B chain, which can bind cell surfaces and is..

Novel Nanoparticles for Drug Delivery

Background Nanoparticles have multiple applications in targeted drug delivery and non-invasive monitoring of therapeutics. The benefits of nano-based drug delivery extend to treatments for infectious ..

Improved Method for Production of Highly Uniform Nanoparticles for Drug Delivery

Formation of Stable Submicron Protein Particles by Thin Film Freezing

Background Therapeutic peptides and proteins such as insulin are difficult to deliver through the digestive tract, so they are usually delivered by injection. Inhalation offers a much simpler, painles..

Biodegradable MicroSpheres for Drug and Vaccine Delivery

Very Large Array of Bipolar Electrodes for Sensing of Chemical or Biological Species

Background The development of microarrays is of crucial importance in genomics for genome sequencing or for the determination of gene expression, in proteomics for the identification of pathologic mar..

Ultra Compact Fiber-Optic Endoscope for Optical Interrogation of Targeted Depths Within Tissue for the Early Cancer Detection and Surveillance

Background Cancer is the second leading cause of death in the United States; early detection is the key to treatment. In humans, 85% of all cancer originates in the epithelial tissue, including the es..

Novel Membrane Receptor for Early Treatment of Breast Cancer

Background An orphan G-protein coupled receptor (GPCR) has previously been shown to be involved in estrogen signaling in breast cancer cells. Also, this GPCR has been suggested to be the membrane estr..

Monolithic Integration of Fresnel Lens With Silicon Microscanner for Endoscopic Imaging

Background The U.S. market for medical imaging equipment increased from $6.7 billion in 2005 to an estimated $7.8 billion in 2007. It should reach $11.6 billion in 2012, a compound annual growth rate ..

Model-based Framework for the Detection of Spiculated Masses on Mammography

Background The detection of lesions on mammography is a repetitive and fatiguing task. Only three or four out of a thousand examined cases are malignant, and thus an abnormality may be overlooked. As ..

Method for Ultra-Sensitive Detection of Infectious Agents

Background The sensitive and accurate detection of spores and other infectious agents is essential in clinical environments and biodefense applications. Because of the excellent sensitivities obtained..

Laboratory Assay for Early Diagnosis of Alzheimer's DiseaseBackground

Background Current Alzheimer's disease (AD) diagnostic tools which utilize biological markers have low rates of success or involve invasive techniques that are at best uncomfortable and unreliable. Ot..

Hand-Held Silicon Scanner Enabled Single-Fiber Confocal Microscopy for Cancer Detection

Background The American Cancer Society shows 15 million people were diagnosed with oral cancer in 2004. Cancer cure and survival rates are tied directly to the stage of the cancer at the time of diagn..

Monoclonal Antibody 3D8 - A CD 13 Antibody ( 89008)

A murine monoclonal antibody (mAb) directed against the human CD13 antigen has been developed at Northwestern University. MAb 3D8 appears to be myeloid restricted, reacting with myeloid cell lines, pe..

Transgenic Mice Expressing Superoxide Dismutase ( 94011)

Researchers at Northwestern University have created a unique transgenic mouse model that expressed superoxide dismutase (SOD). This is an excellent animal model for the analysis of Cu- or Zn-superoxid..

Heat Shock Factors HSF1 & HSF2 Rat Monoclonal Antibodies ( 96097)

This invention describes antibodies directed against heat shock factors, HSF1 and HSF2. HSFs (also designated heat shock transcription factors) are involved in the transcriptional regulation of heat s..

KPL1, A Monoclonal Antibody (mAb) Directed Against a Leukocyte Glycoprotein Named P-selectin Glycoprotein Ligand-1 (PSGL-1) ( 97026)

This invention describes a novel mAb, KPL1, that completely blocks the interaction of PSGL-1 with either L-selectin or P-selectin leukocyte adhesion molecules. KPL-1 is therefore useful in studying in..

A Function Blocking Monoclonal Antibody Against alpha4 Laminin ( 99053CIP

Recently researchers at Northwestern University have developed a function blocking monoclonal antibody (mAb) to the a4 subunit of laminins. This antibody, mAb 2A3, inhibits angiogenesis and endothelia..

Analysis of Muscular Activity in Neonatal Animals to Screen for Mutations and/or Drugs that Alter Sleep and Wake States ( 99072)

Northwestern investigators have developed a high-throughput screening method for novel genes and/or drug compounds associated with the sleep and wake state. Previously it has not been possible to scre..

Surface-Associated Delivery of Genes and Oligonucleotides for High Throughput Functionality Analysis (20071ht)

Investigators at Northwestern University have invented a novel system appropriate for the high-throughput analysis of gene function and an approach for the controlled, efficient delivery of DNA or oli..

A Protocol to Experimentally Identify Non-specific, Non Drug-Like Ligand “Hits” from Drug Discovery Screening Assays (20096)

To discover new lead compounds for drug design, large libraries of chemical compounds are screened for their ability to modulate receptor and enzyme protein activity and function. The..

A Protocol to Experimentally Identify Non-specific, Non Drug-Like Ligand “Hits” from Drug Discovery Screening Assays (20096)

Tau-13 Monoclonal Antibody (20081)

Tau-13 is a mouse monoclonal antibody (mAb) that binds to human tau as demonstrated by ELISA and immunoblot assays and is able to stain brain tissue early in Alzheimer’s disease. The Tau-13 mAb woul..

Monoclonal Antibodies for Laminin-5 and Hemidesmosomes (21015)

This invention describes a number of monoclonal antibodies (Mabs) specific to the different subunits of laminin-5 and hemidesmosomes (HDs). These monoclonal antibodies may be used to study epithelial ..

OSR-1 Nucleic Acids And Proteins (22064)

Investigators at Northwestern University have identified several novel genes that effect dehydration resistance in nematodes: when expression of these genes is modulated, parasitic and beneficial nema..

Dual Function Lipid-Based Transfection Agents: Combination of Drug and DNA Produces Large Increase in Efficiency (22094)

INVENTION: Novel liposomes have been developed that are useful as non-viral vectors to deliver DNA to cells. The invention described herein focuses on the use of lipoplexes with incorporated microtubu..

G Protein Mediated Function as a Target for Malaria Chemotherapy (22096)

Investigators at Northwestern University have identified that beta-blocker drugs are effective inhibitors of malarial infection in vitro and in vivo. Beta blockers are inexpensive, approved to treat ..

Improved Transfection Efficiency Using Combination Lipoids (22112)

Robert C. MacDonald et al., developed novel liposomes useful as transfection agents to deliver nucleic acids to cells for which efficient transfection with conventional agents is difficult. The novel ..

Zinc-Chelating Ratiometric Fluorescent Probes And Related Methods

INVENTION: Investigators at Northwestern University have synthesized a new class of zinc-chelating probes that are useful as ratiometric probes for zinc (Zn(II)). The development of this probe allows ..

Tau C3 Monoclonal Antibody (23065)

Recently, a new antibody specific for caspase cleaved Tau was developed at Northwestern University. This antibody Tau C3, is a mouse monoclonal antibody (mAb) that binds to human tau truncated at aspa..

A Novel Thermo-Gelling Matrix For Microchannel DNA Sequencing (23110

Northwestern investigators have created novel "thermo-gelling" polymer networks for use as DNA sequencing matrices for high-throughput microchannel electrophoresis in capillary arrays. Capillary array..

Tau-12: Monoclonal Antibody Specific For The N-terminus Of Tau (25105)

A mouse monoclonal antibody specific for residues 9-18 in the amino terminus of tau. The antibody is of the IgG1 isotype and is phosphorylation independent. This epitope is lost after cleavage at Asp..

A Rabbit Animal Model For Uterine Fibroid Embolization (26021)

Although uterine artery embolization (UAE) is widely used clinically, an animal model containing actual uterine fibroids does not exist. Development of such an animal model would be desirable as a pla..

Tau-nY29: Monoclonal Antibody Specific For Tau Nitrated At Tyrosine 29 (27006

A mouse monoclonal antibody (IgG1) to detect nitration in a protein-specific and site-selective manner. This antibody recognizes tau only when nitrated on residue Tyr29. It does not cross react with ..

Self-Assembling Membranes and Related Methods Thereof (27009)

A self-assembling liquid polymeric system for the synthesis of robust sacs and string membrane structures having properties suitable for cell and therapeutic delivery, diagnostic and tissue repair app..

Immortalized Retinal Müller Cell Line rMC-1

INVENTION: Müller cells are the most abundant non-neuronal cells in the vertebrate retina. It is known that they perform a variety of functions that support the activities of retinal neurons, but the..

Prestin, the Motor Protein of Cochlear Outer Hair Cells, and its Gene, Pres

INVENTION: Researchers at Northwestern University have isolated a novel molecular motor molecule, Prestin, from outer hair cells (OHCs) of the mammalian cochlea. This unique biological motor is capabl..

INVENTION: The “BioChip” invention electronically detects biomolecules and toxic agents. When a target species chemically binds to the surface of a tiny cantilever probe, the probe deflects and the Bi

INVENTION: The “BioChip” invention electronically detects biomolecules and toxic agents. When a target species chemically binds to the surface of a tiny cantilever probe, the probe deflects and th..

Micro/Nano-Fabricated Glucose Sensors

INVENTION: This invention is a novel glucose sensor that uses the hydrogen-specific gas sensing capability of single walled carbon nanotubes (SWCNT’s) assembled on a microelectrode. The conductivity..

New Silver Containing Cathode for Primary Lithium Batteries for Medical Devices

INVENTION: Northwestern researchers have synthesized a new cathode, Ag4V2O6F2, (SVOF) with significantly higher accessible silver content than current medical battery cathodes employing silver vanadiu..

Rapid Detection of an Anthrax Biomarker by Surface-Enhanced Raman Spectroscopy

INVENTION: Northwestern researchers have created a surface-enhanced Raman biosensor for use in detecting and identifying Bacillus anthracis, a spore-forming bacterium and dangerous pathogen for the di..

Microchannel Assemblies as Artificial Blood-Capillary Beds for Artificial Organs

INVENTION: A thin biocompatible wafer with millions of micron-size channels has been designed to allow for efficient transport in artificial organs. This wafer may be significantly important in artifi..

Surface Enhanced Raman Nanobiosensor

INVENTION: Scientists at Northwestern have created surface-enhanced Raman biosensors for detection of in vivo and ex vivo analytes. In particular, the present invention provides a technology for the i..

Method of Making Silver Vanadium Oxide Material Useful as a Battery Cathode

INVENTION: Ag2V4O11 (SVO) and Ag4V2O6F2, (SVOF) are important cathode materials for medical battery applications such as defibrillators. A one-step process has been developed affording crystalline SVO..

SMOFC Battery Cathode

INVENTION: A novel battery cathode composition having a higher discharge capacity available from silver reduction at a potential above 3V compared to that of the current standard medical battery catho..

Surface-Immobilized Antimicrobial Peptoids

INVENTION: Northwestern researchers have developed peptoid mimics of antimicrobial peptides that can be immobilized onto surfaces, rendering these surfaces capable of compromising the membranes of att..

Method for Identifying Drug Targets in Biological Networks

This is the extension of the bridging centrality network to biological networks. In the network representation, proteins and other biological molecules are the nodes of a network and the interactions ..

High-Throughput Synthetic Platform for Natural Product Analog Libraries

Summary Background: In small molecule drug development, researchers typically develop biased libraries in which all members share a particular characteristic, such as an ability to interact with a par..

Novel Peptide Therapeutic for Multiple Sclerosis

Summary Background: In Multiple Sclerosis, the hostâ€™s immune system (lead by T cells) attacks and destroys myelin basic protein, the principle component necessary for nerve transmission. Part a..

Application of streptococcus intermedius intermedilysin (ILY) for obesity treatment and contraception

Summary A bacterial toxin has been shown to enhance immune reactions to adipocytes when injected locally, facilitating antibody-mediated and complement-dependant cytolysis. Applications A peptide t..

SMERs: Small Molecule Enhancers for Treatment of Cancer and Neurodegenerative Diseases

Summary Background: Autophagy is the process by which cells cannibalize cellular elements such as proteins and organelles to generate intracellular metabolites for cell survival and cell death. For ex..

Inhibition of Sirt$ for treatment of obesity and ehancing fat metabolism

Summary A method of screening for compounds that modulate SIRT4 fatty acid oxidation activity. SIRT4 is a mitochondrial protein that plays a central role in regulating amino acid stimulated insulin..

Inhibitors of Cellular Necrosis

Summary A new paradigm in cell death has been discovered, Necroptosis. Necroptosis reflects a distinct mechanistic pattern of programmed cell death that combines elements of passive unregulated necros..

ras Oncogene Inhibitors

Summary Activated ras genes have been associated with a number of human cancers. An activated ras gene, H-ras-1, was the first non-viral oncogene discovered. Several other human ras proto-onco genes h..

Hyperactive mutant of the Himar1 mariner transposase

Summary Mariner-family transposable elements are active in a wide variety of organisms and so are important genetic engineering tools. The Himar1 element, isolated from the horn fly, Haematobia irrita..

"Teabag" Processing: An Automated, High Throughput Method for Affinity Purification

Summary A high throughput system for protein purification has been developed, whereby a â€œtea-bagâ€ structure is used to house microspheres for targeted protein binding and elution. The micr..

Selective Detection of Phosphoproteins

Introduction Mass spectrometry enrichment and detection of phosphoproteins is critical to cancer research and drug development, among many applications. In MALDI-TOF mass spectrometry, metal plates de..

Programmable Generation and Transport of Droplets on Microscale Surface Texture Ratchets

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications. Currently, many laboratory processes can be combined on a single chip commonly only mill..

Optimal Fitting of Prosthetic Limbs: Evaluation of Prosthetic Socket Quality and Soft-Tissue Response

Introduction The process of fitting prosthetic limbs to amputees can be a long process of trial and error. Two common obstacles to the optimal fitting of prosthetic limbs are improperly tooled prosthe..

An optical spectroscopic approach for quantifying Hb/Mb ratio noninvasively noninvasively

Introduction Impaired blood flow and mitochondrial defects are involved in a wide variety of metabolic and degenerative diseases. The inability to quantify tissue hemoglobin (Hb) content presents a si..

Biomarkers for Cardiovascular Disease

Introduction Cardiovascular disease (CVD) is the leading cause of death among both men and women in the United States and, as such, is associated with high costs in terms of health care, morbidity, an..

Oxidation Resistant form of Apolipoprotein A-I

Introduction High density lipoprotein (HDL) protects against atherosclerosis by removing cholesterol from cells of the artery wall. Apolipoprotein A-I (apoA-I), which accounts for ~70% of the total pr..

Fabrication of Gold Nanocages and Cubic Nanoframes for Biomedical Treatment through Etching Nanoboxes

Introduction Because of their small sizes and unique properties, nanomaterials are finding widespread use in studying complex biological systems. Gold nanostructures have been the subject of intensive..

Automated Yeast Pedigree Analysis

Introduction Saccharomyces cerevisiae, or budding yeast, is a single-cell eukaryotic microorganism that commonly is used by biologists to study genetics. Yeast pedigree analysis is used to study genom..

The Multiple Drug Resistance Gene, Polymorphisms, and uses Thereof

Introduction Multiple drug resistance is a well-documented phenomenon and critical problem in the treatment of various diseases including cancer and HIV. While there are many mechanisms leading to mul..

A Bifunctional Poly(ethylene glycol) Silane Immobilized on Metallic Oxide-Based Nanoparticles for Conjugation with Cell Targeting Agents

Introduction Magnetic resonance imaging (MRI) is a non-invasive diagnostic and therapeutic methodology. The limitations of this imaging system are in its resolution. Lesions within the body must be ap..

Pulsation-Induced Thyroid Strain Imaging

Introduction Thyroid nodules are swellings that develop on the thyroid gland. Often they are benign, but in some cases they are cancerous. Making this distinction is important because 19-36% of the ge..

Localization Wire for Surgical Excision of Breast Lesions

Introduction With the introduction of screening mammography, the median tumor size has decreased considerably, and approximately half of breast cancers in surgical practice are non palpable and amenab..

Surface Receptor Antigen Vaccines

Introduction The invention relates to DNA vaccines, or vaccines containing molecules encoded by such DNA, for the induction of specific, sustained high titer antibody responses. More specifically, the..

Devices and Methods for Hysterosonographically Guided Endometrial Biopsy

Introduction Through examination of the interior body cavities, a wide variety of undesirable health conditions may be diagnosed and treated, including endometrial carcinoma. A variety of biopsy devic..

Improved use of Recombinant Viruses for Liver Regeneration

Introduction Diseases of the liver, both genetic and acquired, are especially detrimental due to the fact that the liver is a key organ for most metabolic pathways. Currently, the only method of curin..

Novel Thymidylate Synthase Mutants For Treating Chemotherapy-induced Mucositis and Other Chemotherapy Side Effects

Introduction 35 novel thymidylate synthase (TS) mutants have been generated by random mutagenesis. These mutants are different from wild type TS in single, double, or multiple mutations, which are loc..

Magnetic Nanoparticle-conjugates as Contrast Agents or Drug Carriers for Cancer Diagnosis and Therapeutics

Introduction There is a growing interest in developing nanoparticle-based targeting agents for tumor diagnostics and therapeutics. Using these agents, tumors and diseased tissues can be detected at th..

Porphyromonas gingivalis LPS as an Immune Modulator

Introduction Vaccines often require the use of adjuvants, immune modulating substances, to generate adequate immune responses for the prevention or treatment of disease. Current adjuvant systems often..

Diagnosis and Treatment of Malignancy

Introduction Novel methods for the detection, monitoring, treatment, and prevention of malignancies have been developed that are based on the body’s own immune response to cell surface markers on ca..

Compositions and Methods for Detecting Pancreatic Cancer

Introduction Pancreatic cancer is a highly lethal disease; it is highly invasive and unresponsive to standard chemotherapy. The discovery of genes that cause familial forms of cancers has often shed l..

Molecules and Methods for the Treatment and Detection of Cancer

Introduction Approximately 30,000 women are diagnosed with ovarian cancer yearly in the United States, and only about 50% of those diagnosed will survive the disease. Early, accurate prognosis of ovar..

Mouse Model of Gastrointestinal Stromal Tumor (GIST)

Introduction Recent developments have firmly established the important role of receptor tyrosine kinases in human cancer. Kit is a receptor tyrosine kinase and its role as a cellular oncogene has been..

Construction and Use of Mutant Herpes Thymidine Kinase Genes in Cancer Therapy

Introduction In addition to surgery, many cancers are also treated with a combination of therapies involving cytotoxic chemotherapeutic drugs and/or radiation therapy. However, disadvantages to this m..

Methods and Compositions to Quantitate Thyroglobulin in Human Blood Specimens

Introduction Thyroglobulin is a marker of thyroid cancer. The presence of thyroglobulin in the plasma/serum of patients indicates functioning thyroid tissue. Following surgery and treatment with radio..

Grasper Pad Sensing

Introduction Minimally invasive surgery is now being used routinely as one of the most preferred choices for various types of operations. Despite its many advantages, such as reduction of trauma, less..

Transgenic Mice Expressing Human Myeloperoxidase

Introduction Myeloperoxidase (MPO) co-localizes with macrophages in the human artery wall, and its characteristic oxidation products have been detected in atherosclerotic lesions. Thus, oxidants produ..

A Microfluidic Device and Methodology for Rapid, Quantitative Determination of Analyte Concentration in a Fluid Sample

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, especially for biosensors and environmental monitoring. One recent area of interest is p..

A Novel Diagnostic Test for Atherosclerosis and Clinically Active Coronary Artery Disease

Introduction Low levels of high density lipoprotein (HDL) are associated with a greatly increased risk of coronary artery disease (CAD). Evidence indicates that HDL protects against atherosclerosis by..

Warfarin Dosing and Genetic Variation

Introduction Warfarin is an anticoagulant used to prevent the blood from forming dangerous clots that could result in stroke. Determining the most effective and safest dose for each patient is extreme..

Phospholipid Transfer Protein, a Regulator of Cholesterol

Introduction The level of cholesterol in the blood is an important risk factor for atherosclerosis and coronary artery disease (CAD) which can eventually lead to heart attack or stroke. Cholesterol is..

Streptavidin Mutants having Secondary Functional Domains

Introduction Streptavidin, a protein produced by Streptomyces avidinii, forms an extremely strong and specific non-covalent complex with the water soluble vitamin biotin. This binding affinity is so s..

Targeting Drugs to the Lymph Nodes for HIV and Cancer Therapies

Introduction HIV patients are currently treated using “HAART,” a highly active anti-retroviral therapy in which a plethora of drugs are administered to patients. This therapy is effective in reduc..

Methods of treating pulmonary disease using acetazolamide and structurally related derivatives

Introduction Alveolar hypoxia, as occurs with chronic lung diseases or ascent to high altitude, results in hypoxic pulmonary vasoconstriction (HPV). Exaggerated HPV causes high altitude pulmonary edem..

Treatment of Microvascular Angiopathies

Introduction Acute injuries to smaller blood vessels and subsequent dysfunction of the tissue in which the injured blood vessels are located (microvascular angiopathies) are common features of a varie..

Non-toxic protocol to establish paraoxonase 1 (PON1) status

Introduction Paraoxonase 1 (PON1) is a member of a three-gene family localized on human chromosome 7. Due to its role in the metabolism of both lipids and organophosphorus (OP) compounds, genetic var..

Automatic detection of vascular bleeding by Doppler ultrasound

Introduction Blood loss from extremity wounds is the number one cause of death in US soldiers in the battlefield today. Blood loss can lead to hemorrhagic shock within minutes if not properly treated ..

Thin-Profile Transducers for Intraoperative Hemostasis

Introduction High Intensity Focused Ultrasound (HIFU) locally heats and destroys unwanted tissue with minimal or no invasion of or damage to surrounding tissue. Thin profile HIFU applicators may be us..

Platelet Clotting Force Array

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, such as point-of-care diagnostic devices. These microscale diagnostic platforms will ena..

BCRP expressing cell lines

Introduction The breast cancer resistance protein (BCRP) is an ATP-binding cassette efflux transporter originally identified by its ability to confer multidrug resistance in cancer cells. BCRP mediate..

A Mouse Model for Osteoporosis

Introduction Osteoporosis, an age-related disease in which loss of bone mass causes skeletal deformities and fractures, affects nearly 20 million people in the US, mostly women. A major complication i..

Type III Adenylyl Cyclase Gene Knockout Mice

Introduction The olfactory sensory system has the remarkable capacity to detect and discriminate among a wide array of odorants and translate them into cognitive representations. Cyclic nucleotide–g..

Zinc Transporter-3 Knockout Mouse

Introduction The presence of histochemically reactive zinc within synaptic vesicles defines a subset of neurons that have been termed zinc-enriched (ZEN) neurons. Because ZEN neurons are prevalent thr..

Circulating Fluidized Beds for Continuous Protein Refolding

This technology enables the continuous handling of heterologous inclusion proteins, minimizing the attrition often seen from repeated batch handling. Description Background Many recombinant ex..

High Efficiency Photocatalytic Reactor for Water Treatment: PhotoCREC Water

Device that utilizes a titanium dioxide catalyst supported on a solid media to enhance the natural activity of UV light to destroy the toxic organic contaminants in water

Haptic Feedback System for Minimally Invasive Robotic Surgery

A novel Minimally Invasive Surgery (MIS) robotic system that successfully incorporates haptic feedback control. Description Background Minimally Invasive Surgery (MIS) was established as a..

Agricultural De-Nitrification Reactor for Contaminated Run-Off

A passive reactor system for the containment and treatment of nitrate contaminated agricultural runoff - or an “Agricultural Basket”. Description The common agricultural practice of o..

Apparatus and Method for Cell Culture

A method for controlling the properties of the microenvironment surrounding a single cell in a cell culture. Background Typically, cells are cultured in vitro by growing cells in a fluid or gel-..

DIABETES FOOD ADDITIVE, NEUTRACEUTICAL & DRUG

Project 1: We currently are marketing / outlicensing a diabetic food additive / neutraceutical. Possible Drug development aspects. Project 2: We are looking for a grant, an angel investor(s) and..

Process for the treatment of pig manure

Agriculture and Agri-Food Canada is offering a commercialization opportunity involving the treatment of liquid pig manure using magnesium smelting by-products. Description The problem: Swine manu..

Antimicrobial technology against Antibiotic Resistant Bacteria

A team at Agriculture and Agri-Food Canada (AAFC) has discovered a formulation of a new group of active antimicrobial ingredients based on a novel mechanism of protection of β-lactam antibiotics agai..

Neuroprotective Agent for the Treatment of Ischemic Stroke

Novel neuroprotective peptide agent capable of reducing the amount of ischemic brain injury. Description Researchers at the Centre for Addiction and Mental Health have developed a novel neuroprot..

SIGMA2

A system for the integrative genomic multi-dimensional analysis of cancer genomes, epigenomes, and transcriptomes

Asthma Quiz for Kidz

The Asthma Quiz for Kidz is a simple and attractive self-administered 6-item questionnaire to assess asthma control in children and adolescents. A score of 2 or more is indicative of poor asthma contr..

Quiz sur l'asthme pour les jeunes

Le Quiz sur l'asthme pour les jeunes est un questionnaire de 6 questions auto administré, simple et amusant servant à l'autoévaluation de la maîtrise de l'asthme chez les enfants et adolescents. U..

Teste sobre a asma para crianças

PARA-SCI: The Physical Activity Recall Assessment for People with Spinal Cord Injury

A reliable and validated tool for measuring physical activity among people with Spinal Cord Injury. Available for download together with guidelines and scripts for administering the tool. Now availabl..

CONTROLLING T LYMPHOCYTE MEDIATED IMMUNE RESPONSES (RDLP#348)

The present invention relates to a prominent peptide epitope, ABBOSS or BSA148 that is targeted by abnormal immunity in autoimmune diseases such as Rheumatoid arthritis, Type 1 diabetes, and primary S..

University of Nebraska-Lincoln Technology Out-Licensing Opportunities

The Lincoln, Nebraska-based Office of Technology Development (OTD): http://otd.unl.edu/ manages the intellectual property assets of the University of Nebraska-Lincoln. OTD’s mission is to help turn ..

IMMORTALIZED RAT SKELETAL MUSCLE CELLS (L6) EXPRESSING GLUT4MYC GLUCOSE TRANSPORTER (RDLP#437)

The inventors have created an L6 myoblast cell line that stably expresses the GLUT4 protein containing a fourteen amino acid Epitope of human c-myc within its first exofacial loop Background In..

L6 RAT SKELETAL MUSCLE CELLS (RDLP#429)

The inventors have subcloned an L6 myoblast cell line that was selected for high fusion capacity as these cells differentiate into myotubes. Background Approximately 40% of people with diabetes ..

Biomarkers for Heart Failure and Death

This technology uses a novel biomarker panel for predicting heart failure and death in an ACS population. Description Patients who present with chest pain at the emergency department may have p..

Diagnostic Method to Detect Endometriosis

A non-invasive development of a test for the diagnosis and monitoring of endometriosis. Description The endometrium is the tissue that lines the uterus and is normally shed each month during the..

Easier, Safer and More Effective Oncolytic Viral Therapy

This innovative therapy exploits the species specificity of both interferon and the Herpes viruses to produce a safer, more effective and easier to produce oncolytic viral therapy. Description On..

High Efficiency mRNA Translation

Researchers at McMaster University have devised a novel method that involves the coupling of specific nucleotide sequences at the 5'- and 3' -ends of a nucleic acid molecule transcribable to the mRNA ..

New Tool to Investigate Protein Interactions

This platform technology is a unique, alternative, high-throughput method for investigating the functions of intact proteins, in their native state, in vivo and identifying protein interactions. It ov..

New Tools Against Thrombotic Disease

The McMaster technology presents a significant step towards the treatment and management of pathological thrombosis and embolism. Novelty This discovery is unique in targeting the molecular ..

Non-invasive Test Assists Treatment Decisions for Cancer Patients

This non-invasive test can be used as a tool to predict responses to radiation therapy in cancer patients, and therefore is a huge step forward in determining treatment decisions in cancer patients. ..

Novel Antibacterial Target and Novel Antibiotic

This technology targets a novel antimicrobial target, that of lipoprotein biosynthesis in Gram-negative bacteria. Description Multidrug-resistant bacteria are a growing problem in health-care. Th..

Novel Therapeutic Target for ER Stress Related Diseases

The patent on this McMaster proprietary technology claims a therapeutic benefit whereby manipulating the expression of this protein may prevent premature atherosclerosis. Description Novelty ..

Targeting Collagen Synthesis for the Treatment of Malignant Tumours

A novel cancer therapeutic with particular relevance for tumours that have a high degree of fibrosis such as breast cancer & pancreatic cancer Description Novelty Current methodologies to inh..

Premenstrual Symptoms Screening Tool (PSST)

Developed by researchers at McMaster University, the Premenstrual Symptoms Screening Tool (PSST) is an instrument to measure the severity and impact of premenstrual symptoms and a timely qualification..

Streptogramin Antibiotics

Class B streptrogramin antibiotics that are impervious to resistance. Description Streptogramin antibiotics such as the agriculturally valuable virginiamycins (Stafac®) and the clinically import..

Method to Rapidly Search and Classify DNA Barcodes

A very rapid search algorithm that was specifically developed to search through large databases of small regions of DNA. Description A DNA barcode is a relatively short sequence of genomic DNA th..

BHV-1 Neutralizing scFv Antibody

Recombinant single chain variable fragment (scFv) antibody capable of neutralizing Bovine Herpes Virus Type-1 (BHV-1) Description BHV-1 is an important pathogen of cattle, which causes a variety..

Vaccine for Necrotic Enteritis in Poultry

Several target antigens suitable for use in a vaccine against Clostridium perfringens infection in poultry, enabling control of necrotic enteritis without antibiotics Description Necrotic enterit..

Enviropig™

Pigs with the ability to utilize efficiently phytate phosphorus (P) that is present in plant feed ingredients. Background Most phosphorus in plants is present in the phytate form. Conventional mo..

Genetic Methods to Reduce Boar Taint in Entire Male Pigs

The University of Guelph is actively developing a genetic tool kit that will be useful in breeding entire male pigs that are low in androstenone and skatole, the main components of boar taint. Descrip..

New Vaccine Methods

Membrane vesicles from Gram-negative bacteria can be used in vaccines Description Many gram-negative bacteria produce membrane vesicles during normal growth. These membrane vesicles have all of t..

Prion Detection Method

Guelph researchers have developed a rapid method to detect prion proteins that are the cause of transmissible spongiform encephalopathies (TSEs) in mammalian species. Description A rapid method h..

Veterinary Ultrasound Video

Training video describing the use of ultrasound on dogs, complete with precise labelling of organs and structures and expert narration. Description This video represents a significant advance ..

Bioactive paper for detection and removal of organophosphates and lactones

Bioactive paper containing a thermostable enzyme capable of degrading organophosphate, organosulfur, and acylhomoserine lactone compounds Advantages Wide range of potential applications Thermost..

Artificial Truffles

An inexpensive version of the rare and expensive French truffle, deemed similar in taste and texture by local truffle experts. Developed at the University of Guelph. Description French truffles a..

Mint Variety Useful for Treating Allergies

A mint variety that produces very high levels of rosmarinic acid, a powerful antioxidant and anti-inflammatory. Developed at the University of Guelph Description Guelph researchers have developed..

Novel Food Oil Structuring Product

A new class of organogelator that is derived from foods such as soybean and dairy products. Background The structure of many food products is based on triacylglycerol from a hardstock. While the ..

Novel Probiotic Extracts

Bioactive compounds from probiotic bacteria that have been shown to prevent infection by harmful bacteria such as E. coli and Salmonella. Background Probiotic bacteria have long been shown to hav..

Gene Related to Peroxisomal Disorders

A gene to enable the study plasmalogen deficiency and its role in human disease Description This invention consists of the gene and promoter for ethanolaminephosphate cytidylyltransferase (ECT). ..

Novel Antibiotic Targets

Due to the continued emergence of drug- resistant bacteria, there is an increasing need for new targets and new therapies for antibiotic treatment. This invention consists of novel bacterial targets t..

Novel Synthetic Lung Surfactants

A significant improvement over current animal-derived and synthetic exogenous preparations, this synthetic preparation has chemical constituents that greatly enhance their stability against lipase deg..

Potential Treatment for Polycystic Kidney Disease

This invention relates to method to treat polycystic kidney disease (PKD) using a saponin-enriched alcohol extract from soy protein isolate. Kidney morphometric analysis shows that mean cyst volume, a..

Uterine Diagnostic Tools for Potential Pregnancy

Uterine natural killer (NK) cells are required during pregnancy to maintain the integrity of the decidualized uterine stroma and for initiating decidual artery instability. Inadequate quantities of th..

Harvest Inducible Promoter

Three plant promoters and a method to locate other plant promoters that are only induced upon harvest have been identified in alfalfa. Advantages The present invention offers a number of competit..

Phytoremediation Using Geraniums

The invention relates to the use of geraniums (Pelargonium spp.) to remediate soils contaminated with heavy metals. The plants surpass all of the requirements for an ideal hyperaccumulator including r..

Non-Pathogenic Burkholderia Strain

A non-pathogenic strain of Burkholderia cepacia provides an opportunity to develop a live vaccine to prevent Bcc infection in CF and critically ill patients, which would dramatically improve the quali..

Novel Protein Translation Inhibitor

A novel drug target and peptide(s) designed to inhibit protein synthesis by specifically preventing formation of the 43S preinitiation complex Background The global cancer market was valued at US..

A non-invasive test of oocyte quality in assisted conception

An innovative, real-time test of oocyte quality, applicable to assisted conception treatments, that does no harm to the oocyte itself. Background Assisted conception treatments have become essent..

A Secreted Therapeutic and Drug Discovery Target for Early Stage Osteoarthritis

A diagnostic and therapeutic secreted target protein that is upregulated in a subset of human patients with OA. It is a strong regulatory candidate for the transformation of maintenance chondrocytes i..

Diagnostic System for Early Stage Osteoarthritis and Therapeutic Discovery

The present invention relates to osteoarthritis (OA) and methods of OA diagnosis and treatment via the findings of a genome-wide analysis of dysregulated genes in OA. Background OA is the most pr..

Non-Transgenic Rodent Model For Alzheimer’s Disease and Cerebral Ischemia

A non-transgenic, adult onset rodent model for Alzheimer’s disease and stroke. Background Alzheimer’s disease is a gradual progressive dementia affecting both cognition and behavior. It is ch..

Novel Peptide Therapeutics for Bone Regeneration

A suite of proprietary collagen-binding peptides derived from bone sialoprotein (BSP) that are effective in promoting bone repair and regeneration. Background The worldwide orthopedic industry is..

Novel Therapeutic Approach to the Prevention and Treatment of Staphylococcus Aureus Infections

A suite of highly specific, proprietary bacterial drug targets in staphylococcus aureus, that can be used individually or as a group to develop small molecule or peptide drug leads with powerful anti-..

Target for the Diagnosis and Treatment of Osteoarthritis

This technology is based on changes in the protein expression profile of osteoarthritic cartilage, which represents an opportunity to develop diagnostic kits and targeted therapies for OA. Background ..

Murine Mammary Carcinoma Cell Line C3L5

A highly metastatic murine breast cancer cell line that provides an excellent mouse model for fundamental as well as therapeutic studies of human breast cancer metastasis. Background Cancer anima..

Novel Compounds for Inhibiting Abnormal Cell Proliferation (RDLP# 510)

This technology consists of: (1) a group of novel compounds useful for modulating abnormal cell proliferation, (2) a pharmaceutical composition, (3) a method modulating cell proliferation, (4) a proce..

Unique Treatment for Type 2 Diabetes and Islet Cell Transplantation (Ref. #1354)

Our technology is a peptide therapeutic that prevents the formation of IAPP aggregates. These 3-6 amino acid peptides have been shown to improve islet cell survival in vitro so more cells are availabl..

Thermal Dependent Injectable Polymer Matrix (Ref. #1421)

The technology is a novel drug delivery polymer matrix comprising an inverse thermal gelling polymer with an anionic polymer. This polymer matrix is faster gelling than each of the separate components..

Nano-Composite Polymeric Membrane System for Drug Delivery (Ref. #1496)

The invention is a composite polymeric system to provide enhances stimuli-responsiveness. The first aspect provides particles including nanoparticles or microspheres in which the particles are made of..

Novel Supramacromolecular Polymer Complexes Providing Controlled Nitric Oxide Release for Healing Wounds (Ref. #1489)

To overcome these deficiencies, UofToronto researchers have developed a novel, stable and biocompatible system for generating a durable release of NO. This technology is based on the discovery that a ..

Linker Microemulsions as a Transdermal Drug Delivery Vehicle (Ref. #1452)

The development of formulations based on low-toxicity and/or natural ingredients represents a clear solution to this problem, especially for longer-term or continual use applications common to the cos..

Mitochondria Penetrating Peptides (Ref. #1512)

The inventors have developed a new class of CPPs called mitochondria penetrating peptides (MPPs) that exhibit the unique characteristic of specifically localizing to the mitochondria. These MPPs, can ..

Chip-Based Platform to Investigate Small Arteries (Ref. #1519)

The chip-based platform is a technology that greatly improves experimentation with microvessels. This polymer chip accurately mimics a physiological environment in which a microvessel can be loaded an..

Compounds for Modulating Cell Proliferation (RDLP# 499)

The technology relates to benzene substituted derivatives of halogen-, aryl- and alkoxy-substituted cyanoester compounds and their use for treating a variety of cell proliferative disorders including ..

A prognostic test for B-cell chronic lymphocytic leukemia (Ref. #1494)

Researchers at Sunnybrook Health Sciences Centre have developed a prognostic test that indicates whether a B-CLL patient is in the indolent or aggressive stage, and therefore whether treatment should ..

Monitoring Cell Response to DNA-Damaging Agents (RDLP# 554)

This invention relates to methods (1) for using biodetectors to monitor cellular responses to stress in particular to DNA damage-inducing agents (2) methods for monitoring the efficacy of anti-cancer ..

Novel Phospholipid Compositions and Biomarker for the Diagnosis and Treatment of Lung Disease (RDLP# 525)

This invention includes: (1) phospholipids PC formulations for patients with lung disease and pathology related to decreased surfactant levels, (2) a biomarker/clinical indicator for identifying reduc..

ß-parvin Acts as a Tumor Suppressor in Breast Cancer Through Inhibition of ILK Signaling (RDLP# 513)

ß-parvin inhibits ILK signaling and suppresses cellular transformation in breast cancer. Background ß-parvin is a widely expressed member of a family of adaptor proteins, which are implicated ..

Susceptibility Gene for Inflammatory Bowel Disease (RDLP# 540)

The inventors have identified three SNPs in the receptor protein tyrosine phosphatase sigma gene (PTPRS), which are associated with UC, and one associated with CD. Background It is estimated tha..

Novel Molecular Diagnostics for Multiple Sclerosis (RDLP# 614)

The invention relates to a method of diagnosing multiple sclerosis (MS) via an in vitro test. Background Over 2.5 million people globally suffer from Multiple Sclerosis (MS). With the present gl..

Novel Strategy in Manipulation of Stem Cell Fate Specification

A novel methodology of regulating and inducing stem cell differentiation by altering the expression of a key protein that is naturally existing and participating in embryo development. Background ..

Novel Disposable Contact Lens Based Glucose Biosensor

A novel disposable contact lens biosensor for the continuous, non-invasive monitoring of physiological glucose for diabetic patients. Background In diabetes mellitus, insulin production and/or ..

Adapter Gene (RDLP#457)

This invention consists of the identification and cloning of a novel gene, MARS (Modulator of Antigen Receptor Signaling). MARS is a putative tumour suppressor gene. Background An estimated 44,2..

METHODS OF ASSESSING SEVERITY OF PULMONARY DISEASE AND ITS TREATMENTS (RDLP#589)

The present invention relates to the development of a molecular DNA-based test for genetic variants, which are predictive of higher susceptibility to bacterial infections and severe pulmonary disease ..

ILK-Mediated Stem Cell Proliferation as a Novel Therapy for Acute Cardiac Damage (RDLP# 528)

The invention relates to a therapeutic method to promote cardiac repair after acute myocardial damage through the activation of ILK, stem cell proliferation, migration and survival Background Rec..

ILK-Induced Cardioprotection as Novel Prophylaxis and Therapy for Acute Cardiac Damage

The invention relates to a method to promote cardiac protection through ILK induced ventricular hypertrophy. Background Recent advances in cardiac physiology identify the integrin-linked kinase (..

NH-7211 – A Broad Acting Anti-Alzheimer’s Compound

Novel small chemical compounds capable of disrupting the three key misfolded proteins responsible for Alzheimer’s disease (AD) and other CNS disorders Description Our researchers have created n..

GRASS CARP SALES

Lethbridge College, Alberta has an Aquaculture Center of Excellence (ACE) that produces sterile Grass Carp for aquatic vegetation control. In Alberta retail buyers can purchase Grass Carp from license..

Sox17 Expressing Human Embryonic Stem Cells–Endodermal Progenitors (RDLP# 613)

The invention of a stable endoderm progenitor cell line established from hES cell lines by constitutive expression of Sox17-producing definitive endoderm progenitors. Background Human embryonic ..

Antimicrobial Peptides (RDLP# 450)

The inventors have developed a new class of proprietary peptides with active antibiotic properties Description The inventors have developed a new class of proprietary peptides with active antibio..

Retinal Stem Cells (RDLP# 383)

The invention relates to the isolation of stem cells from both embryonic and adult mouse retina as well as adult human retina, and includes a method for stimulating proliferation of endogenous retinal..

Novel Susceptobility Biomarkers of Autism (RDLP# 642)

The invention relates to the identification of structural genetic variants (copy number variations/CNV) of chromosomes in individuals with Autism Spectrum Disorder. Background Genomic abnorma..

Neural Crest Stem Cells and Uses Thereof (RDLP# 494)

Background Since stem cells are multi-potent and self-renewing, they may be used as starting material for the production of cell types to replenish lost tissue material in cases when a disease, d..

Novel Chemical Entities Affecting Neuroblastoma Tumour-Initiating Cells (RDLP# 536)

Candidate NB tumor-initiating cells (TICs) have been isolated, and it has been hypothesized that TICs are related to SKPs (Skin-derived Precursors). Background Malignant neuroblastoma (NB) is th..

NutriSTEP™

A nutrition risk screening tool for preschool children, aged 3-5 years. Valid, reliable, bilingual (English and French). Description NutriSTEP™ is a fast and simple way to assess eating habits..

NMQC: A NEMA-based software application for quality control of gamma cameras

UBC researchers have developed a NEMA-compliant software application that functions across manufacturer platforms and allows the user to monitor performance over time Background The NMQC software..

Human Lipase Cell Lines

Background Technology Details: Human hepatic lipase cell line - Chinese hamster ovary (CHO) cells have been stably transfected with a human hepatic lipase cDNA to overexpress this enzym..

Epilepsy, Alzheimers & Parkinson's Drug Development

Upsher-Smith Laboratories, Inc., is a privately held, specialty pharmaceutical company with headquarters in Minneapolis, MN (www.upsher-smith.com). The company is seeking collaborative partners and ou..

Drug Delivery Technologies

Upsher-Smith Laboratories, Inc., a privately held, specialty pharmaceutical company with headquarters in Minneapolis, MN (www.upsher-smith.com), is actively seeking Canadian companies or research orga..

Women's Healthcare

Upsher-Smith Laboratories, Inc., a privately held specialty pharmaceutical company with headquarters in Minneapolis, MN (www.upsher-smith.com), would like to augment its current portfolio with markete..

SPINAL DISC NUCLEUS REPLACEMENT

BACKGROUND In the last 10 years commercial interest in treatment of spinal degeneration in relation to back pain has increased with a large number of devices competing in a market estimated to be wort..

eLUNSERS: A SOFTWARE TOOL FOR MONITORING THE SIDE-EFFECTS OF NEUROLEPTIC DRUGS

BACKGROUND Neuroleptics are the drugs of choice in the treatment of schizophrenia, bipolar mania and related disorders but suffer from troublesome side-effects such as drug induced parkinsonism, restl..

Collaboration/Licence Opportunity Size and Permeability Selective Encapsulation and Delivery of

BACKGROUND Although there is considerable research being carried out in the area of hollow sub-micron constructs for the purposes of encapsulation of useful therapeutic entities, most of the processes..

NOVEL ANTI-HELMINTHIC

BACKGROUND Gastrointestinal nematode infections are amongst the commonest infections of man and animals worldwide. Collectively 1 in 3 people on the planet are infected by at least one species and app..

NOVEL ANTIMICROBIAL PEPTIDES

BACKGROUND Ai2 Limited is a University of Manchester spinout company that aims to become a significant player in the global anti-infectives market. The company’s focus is on developing novel anti-mi..

3-D SELF-ASSEMBLED PEPTIDE HYDROGELS

BACKGROUND Pre-designed self-assembling scaffolds are highly advantageous in a number of areas, including tissue regeneration, 3D cell culture, in vitro toxicity testing and understanding of cell/extr..

BIODRUG DELIVERY MECHANISM VIA YEAST ENCAPSULATION

BACKGROUND A research project in in the Faculty of Life Sciences at the University of Manchester has led to the development of a novel yeast-based drug delivery mechanism. THE TECHNOLOGY A genetically..

mapping and quantifying the contribution of elements to the overall performance of the system they compose

BACKGROUND Research at the University of Manchester has identified a new tissue marker with potential use in the stratification of breast cancer patient groups and improved targeting of treatment for ..

Multi-Silencing Algorithm (MSA) for analysis of ´Multi-Knockout´ and perturbation experiments

The Invention The invention describes a new, reliable and efficient method for mapping and quantifying the contribution of elements to the overall performance of the system they compose. The Need ..

Detoxification of Tannins in Transgenic Plants

A novel genetic system for the elimination of tannins in edible plant materials such as canola seeds and sorghum seeds has been developed. This involves genetic engineering of these plants such that t..

Inhibitors of Systemic Virus Spread in Plants

The Invention Plant viruses and viroids exploit plasmodesmata nano-channels as conduits for viral spread. Plasmodesmal proteins, endogenous to plants, have been modified such that they permanently bl..

Domestication of the Marine Nudibranch Spurilla Neapolitana for Commercial Husbandry: Targeting the Marine Ornamental Industry

The Invention A technology was developed enabling the domestication / commercial husbandry of S neapolitana - The optimal pest control for marine aquaria.The novel technology includes special culture..

Notify me of New Entries on this Page

You can receive an email whenever a new technology for sale is added to this category. You can unsubscribe at any time.

Become a
Paid Problem Solver