Molecular Strategies to Minimize Off-Target Toxicities of Antibody Drug Conjugates

Molecular Strategies to Minimize Off-Target Toxicities of Antibody Drug Conjugates Deadline: 2019-09-30
Award: $15,000
Open to: Everyone*

The therapeutic activity of ADCs depends on recognition of the cell surface target antigen, internalization of the ADC upon target binding, and release of the cytotoxic agent within the cell. Off-target binding of the ADCs results in limited efficacy and unwanted toxicities. The Seeker calls for new molecular (i.e. antibody engineering) and chemical (e.g. linker design, tumor restricted release mechanisms, pro-drug approaches) strategies for creating ADCs that are solely active at the tumor site or at the tumor microenvironment thus minimizing off-target toxicities.

* Details may apply. See contest website to confirm eligibility.

Enter Challenge on This Website:

Molecular Strategies to Minimize Off-Target Toxicities of Antibody Drug Conjugates
You will leave IdeaConnection, and be directed to a 3rd party website.

Next Innovation Challenge »

Notify me of new challenges!

PLEASE ENTER YOUR EMAIL