Dendrimer functionalised nanoparticle label
A label is disclosed comprising a nanoparticle wherein the nanoparticle surface is functionalised to comprise at least one dendrimer having at least one activatable functional group for conjugating a target analyte to the functionalised nanoparticle, wherein the dendrimer has a stabilising effect on the zeta potential at the nanoparticle surface. The dendrimer may be a PAMAM or Newkome dendrimer, and the nanoparticle may be a silica or metal oxide nanoparticle. Nanoparticle labels are also disclosed as above with at least one activatable functional group for conjugating a detection molecule selective for a corresponding target analyte. The detection molecule may be an antibody. Methods of detecting target analytes using the nanoparticle dendrimer labels, and uses of the labels in biological discovery, biomedical detection, therapeutic applications, and in dermatological or in vivo diagnostic devices are also claimed. Methods of preparing the labels are also claimed.
GUBALA VLADIMIR [IE]; GUEVEL XAVIER LE [IE]; NOONEY ROBERT [IE]
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