Modular Monolayer Coatings for Selective Attachment of Nanoparticles to Biomolecules

Nanoparticles are functionalized for use as bio-imaging probes using a novel, modular approach. Particle surface modification is based on a phosphonate monolayer platform on which was built a multi-segmented, multi-functional film: the first segment provided hydrolytic stability, the second aqueous suspendability, and the third, selectivity for cell attachment. In vitro imaging experiments visualized nanoparticle - cell surface binding. Peptide-derivatized nano-particles were not displaced from cells by soluble peptide. Methods for coating the host particles and use of rare earth ion-doped particles in imaging methods and photodynamic therapy methods are also disclosed.

Attached files:
WO 2010008826.jpg

Patents:
WO 2,010,008,826

Inventor(s): SCHWARTZ JEFFREY [US]; TRAINA CHRISTOPHER [US]; DENNES THOMAS J [US]

Type of Offer: Licensing



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