“Artificial nose” based on surface plasmon resonance sensor derivatized with specific biofilms

Introduction Surface plasmon resonance (SPR) sensors can be used for the detection of target chemical, biochemical, and biological analyte binding in a very specific and sensitive manner. One of the biggest limitations to this technology is the speed with which detection can take place. Slow rates of detection make high-throughput binding analyses very expensive as multiple sensors are required. If binding rates were improved, then the practical applications of SPR sensors would be dramatically increased. Technology description A sensor system has been designed by researchers at the University of Washington to mimic olfactory systems using Surface Plasmon Resonance (SPR) as the signal transduction mechanism. The key innovations over traditional SPR sensors is the application of a motive force that allows for the binding kinetics to be altered, thus reducing the time required to detect a particular analyte. Additionally, these methods provide for a choice between either increased specificity or higher dynamic range, depending upon the application. Business opportunity This device is ideal for detecting volatile or diffusible target analytes in a highthroughput manner. Stage of development These SPR sensors have been successfully designed and prototypes are in progress.

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