Nanoparticle Probes for High Resolution Imaging


Semiconductor nanocrystals replace conventional dye molecules as FRET (fluorescence resonance energy transfer) donors for enhanced optical resolution in near field scanning optical microscopy (NSOM)
Applications in high resolution microscopy for biology and materials science FRET is widely used in fluorescence microscopy, fluorescence confocal laser scanning microscopy, and molecular biology, for measuring distances on a molecular scale In vivo and in vitro applications as a contrast mechanism for high resolution optical imaging Our Innovation

A patented method for coating scanning probe tips with nanoparticles to obtain a unique probe tip, combined with unique aperture-less near field microscopy method. Key Features Nanocrystals may be tailored to provide exceptional spectral coverage enabling optimization of donor-acceptor spectral overlap Nanocrystals may be excited efficiently at shorter wavelengths, reducing donor-acceptor cross talk Nanocrystals are significantly more stable emitters than dye molecules, a critical feature for FRET microscopy Development Milestones

Further development in cooperation with companies involved with scanning probe microscopes and reagents The Opportunity Fields from semiconductor manufacturing to materials science to proteomics and key role in enormous industries such as biomedicine and semiconductor manufacturing are constantly seeking microscopy tools with better optical resolution. The 2005 global pharma/biotech market for TR-FRET based assay reagents was estimated to be around $50 million

Type of Offer: Licensing

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