Method and Apparatus for Assessing Polypeptide Aggregation
A method of determining aggregation rate data predicting an aggregation rate of a polypeptide defined by an amino acid sequence, the method comprising determining a hydrophobicity value, a charge value, and at least one shape propensity value for said sequence; identifying one or more aggregation-influencing patterns within said sequence; determining a pattern value for the sequence responsive to said identifying; and determining said aggregation rate data by determining a weighted combination of said hydrophobicity value, said charge value, said at least one shape propensity value, said pattern value and at least one factor extrinsic to said amino acid sequence.
DOBOSON CHRISTOPHER [GB]; CHITI FABRIZIO [IT]; ZURDO JESUS [GB]; DUBAY KATERI HAYASHI [US]; VENDRUSCOLO MICHELE [GB]
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