Modulators of Protein Phosphatase 2a and Pp2a Methyl Esterase
The disclosure relates to modulation of protein phosphorylation, including information derived from the structures and activities of the proteins designated protein phosphatase 2A (PP2A) and PP2A methyl esterase. The disclosure contained herein provides compounds and methods for identification of compounds that antagonize the function of PME, and thus reduce levels of PP2A demethylation activity. Over-expression or gain-of-function of PME contributes to a range of diseases such as cancer, thus inhibition of PME by antagonists may provide a strategy for therapeutic intervention.
Attached files:Patents:US 20,090,239,244
Inventor(s):
SHI YIGONG [US]; XING YONGNA [US]
Type of Offer:
Licensing
« More Biotech Patents