Deglycosylating gp120

Summary This invention describes a method for producing partially deglycosylated HIV-1 envelope glycoproteins through site-directed mutagenesis. Removal of multiple carbohydrate residues by mutation of their consensus N-linkage sites exposes gp160/gp120 protein domains to the host immune system and may lead to enhanced immune response. Such mutated derivations of gp160/gp120 retain normal structure and function, as measured by infectivity of virions bearing the mutated proteins. The invention provides for compositions of deglycosylated HIV-1 glycoproteins and for their administration to mammals for antibody production.

Inventor(s): Essex, Myron E

Type of Offer: Licensing



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