Rapid Protection from Neuronal Failure following Heat-stroke and Hyperthermia
The TechnologyWe have identified that the down-regulation and reduced activity of certain protein kinase signaling molecules by pharmacological intervention allows the central nervous system to both function at much higher temperatures and recover RAPIDLY following heat-induced neural trauma. This observation of thermo-tolerance and thermo-protection of neural circuits in two divergent insect species raises the possibility that this function may be conserved in mammals. Hence, these signaling molecules can be used as targets to develop therapeutic drugs for a posteriori treatment of patients suffering from heat stroke, ischemia-induced hyperthermia, or febrile seizures; it may also be valuable for preventative a priori treatment of patients with conditions predisposing them to hyperthermic neuronal disruption such as malignant hyperthrmia.
Type of Offer: Licensing
« More Pharmaceutical Patents