Selective Exosite Inhibition of PAPP-A Activity Against IGFBP-4.
The present invention relates in one embodiment to PAPP-A exosite(s) interactors such as antibodies which bind to a region comprising LNR3 of PAPP-A and efficiently inhibit proteolysis of IGFBP-4, but not -5. The region comprising LNR3 represents a substrate binding exosite, which can be targeted for selective proteolytic inhibition. Accordingly, the present invention relates in one embodiment to differential inhibition of natural protease substrates by exosite targeting.
Patents:MX 2,010,008,083 [
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Inventor(s):
OXVIG CLAUS [DK]; MIKKELSEN JAKOB HAUGE; NIELSEN CLAUS GYRUP
Type of Offer:
Sale
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