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The following are Biotech technologies offered for sale or license. Viewing technologies for sale is a free service of IdeaConnection.com, as is connecting with the seller if a technology interests you. Click on a heading below for more information.Lacritin-syndecan fusion proteinsThe present invention relates to methods and compositions useful for the regulation of lacritin, syndecan, and lacritin-syndecan interactions and the signaling pathway downstream of lacritin-syndecan ..HYDROGENASE POLYPEPTIDE AND METHODS OF USEProvided herein are polypeptides having hydrogenase activity. The polypeptide may be multimeric, and may have hydrogenase activity of at least 0.05 micromoles H2 produced min-1 mg protein-1. Also prov..CAS6 POLYPEPTIDES AND METHODS OF USEProvided herein are methods for cleaving a target RNA polynucleotide. The target RNA polynucleotide includes a Cas6 recognition domain and a cleavage site, and may be based on a repeat from a CRISPR l..Biotin-facilitated transport in gram negative bacteriaBiotinylation of compounds such as peptides and peptidomimetics facilitates illicit transport of the compounds into Gram negative bacteria.Neuronal progenitors from feeder-free human embryonic stem cell cultureThe present invention relates to methods for producing feeder cell-free neuroprogenitor cells (preferably adherent) from embryonic stems cells, preferably human embryonic stem cells, the feeder cell-f..REVERSE RESTRICTION FRAGMENT LENGTH POLYMORPHISM ASSAY AND USES THEREOFThe present invention presents a Reverse Restriction Fragment Length Polymorphism (RRFLP) method for the detection of the presence of an informative restriction enzyme site in a nucleotide sequence. T..Enhancement of Bacillus Thuringiensis Cry Toxicities to Lesser Mealworm Alphitobius DiaperinusThe subject invention relates in part to the discovery that BtBooster (BtB) peptides enhance Bt strain and Cry protein toxicity to the lesser mealworm. The subject invention also relates in part to th..PROKARYOTIC RNAi-LIKE SYSTEM AND METHODS OF USEProvided herein are methods for inactivating a target polynucleotide. The methods use a psiRNA having a 5' region and a 3' region. The 5' region includes, but is not limited to, 5 to 10 nucleotides ch..PYRIDINONE HYDROXYCYCLOPENTYL CARBOXAMIDES: HIV INTEGRASE INHIBITORS WITH THERAPEUTIC APPLICATIONSNew chiral and achiral oxy- substituted cyclopentyl pyridinone diketocarboxamides and their derivatives and methods for their preparations are disclosed. The compounds include tautomers, regioisomers ..VECTORS COMPRISING A MAGNUM-SPECIFIC PROMOTER FOR AVIAN TRANSGENESISThis invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of a bird and for expressing said exogenous sequences to alter the phenotype..RECOMBINANT AVIAN PARAMYXOVIRUS VACCINE AND METHOD FOR MAKING AND USING THEREOFThe present invention encompasses engineered APMV compositions or vaccines. The vaccine or composition may be a recombinant APMV composition or vaccine. The present invention encompasses methods for m..MODIFIED PEPTIDES HAVING TOXIN-ENHANCING EFFECTS.This invention relates in part to modifying BtBooster (BtB) peptides, in part to increase their stability in insect midgut digestive juices. Some preferred embodiments of BtB have removed proteinase c..ANTI-TRYPANOSOMAL PEPTIDES AND USES THEREOFThe present invention provides methods of killing, inhibiting the growth, and/or inhibiting the reproduction of kinetoplastid protozoan with hydrophobic signal sequence peptides and compositions inclu..PROPHYLACTIC AND THERAPEUTIC IMMUNIZATION AGAINST PROTOZOAN INFECTION AND DISEASEPolypeptide and polynucleotide vaccines effective to treat or prevent infection of a mammal, such as a dog, a cat, or a human, by a protozoan. Methods of treatment and prevention are also provided, in..GLYCOPROTEIN CANCER BIOMARKERThe invention relates to glycoproteins having a cancer-specific glycoform. Cancer-specific glycoforms are useful in diagnostics and therapeutics.Aptamers as agonistsNucleic acid aptamers are described herein which can transduce a signal into cells by crosslinking a cell surface molecule, thereby inducing of one or more biological activities by the cells; in servi..ANTIDOTES FOR AGONISTIC APTAMERSThe present invention relates, in general, to aptamers and antidotes therefor and, in particular, to aptamers capable of binding to and activating molecules, such as receptors (e.g., the OX40 receptor..Single-cell biosensor for the measurement of GPCR ligands in a test sampleThe present invention is related to the detection of GPCR ligands in a test sample by using a single cell biosensor expressing a GPCR. Preferably, the test sample is derived from a biological or envir..DETECTION ASSAY DEVICES AND METHODS OF MAKING AND USING THE SAMEAn article such as a biomolecular detector or biosensor having a nonfouling surface thereon includes:(a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a pol..PREDICTING RESPONSIVENESS TO CANCER THERAPEUTICSProvided herein are methods for predicting the responsiveness of a cancer to a chemotherapeutic agent using gene expression profiles. In particular, methods for predicting the responsiveness to 5-fluo..RESIN ASSISTED CAPTURE OF CYSTEINE-MODIFIED PROTEINS/PEPTIDES AND DETERMINATION OF PRESENCE AND LOCATION OF MODIFICATIONA resin connected by amide bond to pyridyl sulfide or methylthiosulfonate can be conjugated to a post-translationally modified protein/peptide to allow determination of presence and kind and optionall..TREATING ONCOGENIC RAS DRIVEN CANCERSOncogenic Ras-driven cancer is treated with agent by interrupting pathway comprising activation of Akt by oncogenic Ras, activated Akt causing phosphorylation of eNOS at S1177 site of eNOS to provide ..VHH ANTIBODY FRAGMENTS FOR USE IN THE DETECTION AND TREATMENT OF CANCERThe presently disclosed subject matter provides ligands for detecting and imaging cancer cells and tumors, and for guided delivery of an active agent to cancer cells and tumors. In some embodiments th..CHARACTERIZATION OF GRP94-LIGAND INTERACTIONS AND PURIFICATION, SCREENING, AND THERAPEUTIC METHODS RELATING THERETOThe presently disclosed subject matter discloses characterization of interactions between ligands and Hsp90 proteins, including GRP94, wherein ligand binding to the N-terminal nucleotide binding domai..IgG Fc/HIV-gp120/C3d FUSION PROTEINPROBLEM TO BE SOLVED: To provide an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates, and a method for inducing anti-HIV antibodies using the immunogen. ; SOLU..HEDGEHOG SIGNALING AND CANCER STEM CELLS IN HEMATOPOIETIC CELL MALIGNANCIESThe present disclosure relates generally to methods of treating hematopoietic cell malignancy in a subject by administering to the subject a Hedgehog (Hh) pathway antagonist, such as a Smoothen (Smo) ..PHOTOLABILE CAGED TRANSITION METAL COMPLEXES AND METHODS OF USING THE SAMEThe present invention provides compounds of Formula I: ( I ) along with compositions comprising the same and methods of using the same, such as for photodynamic therapy in the treatment of cancer.COMPOSITIONS AND METHODS USING siRNA MOLECULES FOR TREATMENT OF GLIOMASThe present invention provides small interfering RNA (siRNA) molecules, compositions containing the molecules, and methods of using the compositions to treat gliomas.AUTOANTIBODIES IN THE DETECTION AND TREATMENT OF CANCERMethods, kits, and compositions for detecting and/or treating cancer based on detecting and/or administering an antibody, which can optionally be a bispecific antibody, having the immunoreaction chara..Modulation of immune response by non-peptide binding stress response polypeptidesA recombinant stress response polypeptide that lacks an antigen binding domain, and methods for using the recombinant stress response polypeptide to elicit an immune response, for example an anti-tumo..SOUR TASTE RECEPTOR COMPOSITIONS AND METHODSThe present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for sour ..PREDICTING CANCER RISK AND TREATMENT SUCCESSProvided herein are methods for predicting the likelihood of recurrence of a cancer using gene expression profiles. Methods for developing treatment plans for individuals with cancer are also provided..CROSS-SPECIES CHIMERIC RNA MOLECULESMethods to reduce the expression of at least one gene of an intracellular pathogen in a host cell are provided, wherein the method comprises introducing into a host cell a heterologous polynucleotide ..METHODS OF INHIBITING CANCER CELL GROWTH WITH HDAC INHIBITORS AND METHODS OF SCREENING FOR HDAC10 INHIBITORSMethods of inhibiting cancer cell growth using HDAC10 inhibitors are provided. Methods of treating cancer in a subject using HDAC10 inhibitors are also provided. In certain embodiments, at least one s..MONOCLONAL ANTIBODY PRODUCTION IN B CELLS AND USES THEROFThe presently disclosed subject matter provides methods of inhibiting a host innate response to activator-mediated proliferative signals in a primary B cell. In some embodiments a method is provided f..AFFINITY DISPLACEMENT MOLECULAR SEPARATIONProvided herein are methods for identifying molecules that compete with a ligand for binding to a protein. The method comprises contacting a ligand with a proteome to allow protein members of the prot..DELIVERY METHODThe present invention relates, in general, to RNA silencing and, in particular, to a method of effecting targeted delivery of an RNA silencing moiety using a targeting moiety that binds to a cell surf..COMBINATION THERAPY IN THE TREATMENT OF CANCERDisclosed herein is a method of treating a tumor by administering to the subject a treatment effective amount of a therapeutic antibody and an alkylating agent.BIODEGRADABLE COPOLYMER COMPRISING AMYLOPECTIN OR GLYCOGEN SUITABLE FOR DELIVERING NUCLEIC ACID MATERIALS INTO CELLSThe invention is related to a biodegradable copolymer, which is suitable for delivering nucleic acid materials into cells, and which comprises a amylopectin or glycogen and at least one cationic polym..BIODEGRADABLE COMPOSITE SYSTEM AND THE USE THEREOFThe invention relates to a composite system of at least one biodegradable blend containing at least one biodegradable Blockcopolyesterurethan (PEU) and at least one polyhydroxyalkanoate (PHA), optiona..FORMULATION FOR INDUCING BROADLY REACTIVE NEUTRALIZING ANTI-HIV ANTIBODIESThe present invention relates in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies, and, in particular, to a formulation comprising Toll Like Receptor (TLR) agonists with HI..FORMULATIONThe present invention relates, in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies and, in particular, to a formulation comprising a prehairpin intermediate form of HIV-1 e..METHODS OF MAKING CELL SHEETS, TISSUE SHEETS AND TISSUE ENGINEERED BLOOD VESSELSMethods of making cell sheets, tissue sheets and tissue-engineered blood vessels are provided. The methods include culturing cells on a nanoimprinted coated scaffold under hypoxic conditions to form a..MOUSE MODELSThe present invention relates, in general, to animal models suitable for testing candidate immunogens and, in particular, to knock-in mice expressing heavy and light chains of membrane proximal extern..NON-INVASIVE ENERGY UPCONVERSION METHODS AND SYSTEMS FOR IN-SITU PHOTOBIOMODULATIONProducts, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases medi..MODULATORS OF ODORANT RECEPTORSThe present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays ..METHODS FOR LOADING CONTRAST AGENTS INTO A LIPOSOMEThe invention comprises compositions and methods for loading both magnetic resonance contrast agents and therapeutic agents into liposomes, such as low temperature sensitive liposomes (LTSLs). In cert..TEMPERATURE-SENSITIVE LIPOSOMAL PREPARATIONPROBLEM TO BE SOLVED: To provide a liposome useful in methods of administering active agents using mild hyperthermic conditions. ; SOLUTION: There is provided the liposome containing an active agent a..THERAPEUTIC AGENTS COMPRISING ELASTIN-LIKE PEPTIDESThe present invention provides therapeutic agents and compositions comprising elastin-like peptides (ELPs) and therapeutic proteins. In some embodiments, the therapeutic protein is a GLP-1 receptor ag..CHAPERONE-ASSISTED PROTEIN EXPRESSION AND METHODS OF USEThe present disclosure provides methods of utilizing chaperone proteins for the production of active protein such as those encoded by the genes of natural biosynthetic clusters. The methods provided h..PERIPHERAL BLOOD BIOMARKERS FOR IDIOPATHIC INTERSTITIAL PNEUMONIA AND METHODS OF USEThe present invention provides methods for diagnosing several types of diseases. Specifically, the present disclosure provides a panel of diagnostic genes, the differential expression of whose mRNAs o..METHODS OF MANIPULATING CELL SIGNALINGThe disclosure provides for methods of monitoring and/or modulating cell signaling, and specifically, polynucleotides, polypeptides, cells, assays, genetically modified non-human animals, and methods ..N-TERMINAL DIMERIZATION METHODS WITH BIS-AMINDINO ACID-AND BIS-THIOIMIDATE DERIVATIVESThe invention provides high-yield protein dimerization methods using highly reactive bis-thioimidates that may be used in the manufacture of a highly potent anti-cancer peptide dimers.HIV-1 ANTIBODIESThe present invention relates, in general, to HIV-1 specific antibodies and, in particular, to broadly neutralizing HIV-1 specific antibodies that target the gp41 membrane-proximal external region (MP..INHIBITION OF ENDOSOMAL TOLL-LIKE RECEPTOR ACTIVATIONThe present invention relates, in general, to pattern-recognition receptors (PRRs), including toll-like receptors (TLRs), and, in particular, to a method of inhibiting nucleic acid-induced activation ..COMPOSITIONS, METHODS AND KITS FOR ELICITING AN IMMUNE RESPONSEThe present invention relates to compositions, methods, and kits for eliciting an immune response to at least one CMV antigen expressed by a cancer cell, in particular for treating and preventing canc..Conjugates prepared with aggregate-free proteinsA naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conj..TISSUE ENGINEERINGThe present invention relates, in general, to tissue engineering and, in particular, to a method of extending the lifespan of cells suitable for use in vascular engineering. The present invention r..Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNAThe present invention relates to methods for producing an RNA-loaded antigen presenting cell (APC), said method comprising introducing into an antigen presenting cell in vitro RNA encoding an immunomo..PEG-URATE OXIDASE CONJUGATES AND USE THEREOFA naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG..COMPOSITIONS AND METHODS FOR ENHANCING ODORANT RECEPTOR ACTIVITYThe present invention relates to polypeptides capable of modulating odorant receptor activation. In particular, the present invention provides polypeptides (e.g., type 3 muscarinic actetylcholine rece..MICRORNA AND USE THEREOF IN IDENTIFICATION OF B CELL MALIGNANCIESDisclosed are nucleic acid sequences, including microRNA sequences and cDNA sequences, as well as vectors, DNA libraries, microarrays, and recombinant cells comprising the nucleic acid sequences descr..METHOD OF INDUCING AN ANTI-VIRAL IMMUNE RESPONSEThe present invention relates to a method of inducing an anti-viral immune response. The method comprises administering to a patient in need thereof an antigen that induces the production of antibodie..HEMATOPOIETIC STEM CELL GROWTH FACTORThe present invention relates, in general, to stem cells and, in particular, to a hematopoietic stem cell (HSC) growth factor and to methods of using same.RNA aptamers and methods for identifying the sameRNA aptamers and methods for identifying the same are disclosed. The RNA aptamers selectively bind coagulation factors, E2F family members, Ang1 or Ang2, and therapeutic and other uses for the RNA apt..ANTI-CD19 ANTIBODIES AND USES IN B CELL DISORDERSThe invention relates to immunotherapeutic compositions and methods for the treatment of B cell diseases and disorders in human subjects, such as, but not limited to, B cell malignancies and autoimmun..INTEGRATED DROPLET ACTUATOR FOR GEL ELECTROPHORESIS AND MOLECULAR ANALYSISThe invention is directed to a droplet actuator device and methods for integrating gel electrophoresis analysis with pre or post-analytical sample handling as well as other molecular analysis processe..COMPOSITION AND METHODS FOR ELICITING AN IMMUNE RESPONSEThe present invention relates to compositions, methods, and kits for eliciting an immune response, in particular for eliciting an immune response to at least one antigen expressed by a cancer cell, in..URATE OXIDASEThe present invention relates, in general, to urate oxidase (uricase) proteins and nucleic acid molecules encoding same. In particular, the invention relates to uricase proteins which are particularly..VIRAL MICRORNAThe present invention relates, in general, to micro RN As and. in particular, to viral microRNAs expressed by Herpes Simplex Vims 1 (HSV-1) or Herpes Simplex Virus 2 (HSV-2), to agents that inhibit su..TRIMODAL CANCER THERAPYCancers are treated with three types of agents: a chemotherapeutic agent which induces lymphopenia; an inhibitory antibody to a surface marker on Treg cells; and an anti-cancer vaccine. This combinati..REGULATORY B CELLS AND THEIR USESThe present invention relates to a phenotypically distinct CD1dhigh CD5+ B cell subset that regulates T cell mediated inflammatory responses through the secretion of interleukin-10 (IL-IO). The invent..INDOLINE SCAFFOLD SHP-2 INHIBITORS AND CANCER TREATMENT METHODThe subject invention concerns methods and compounds for inhibiting Shp2. In one embodiment, a compound of the invention has a chemical structure as shown in formula I or II: wherein X, Y, and Z are i..PROTEASOME INHIBITORS FOR SELECTIVELY INDUCING APOPTOSIS IN CANCER CELLSThe subject invention concerns compounds having activity as inhibitors of proteasomes and methods of using the subject compounds. In one embodiment, a compound of the invention has the chemical struct..SUBSTRATE-MIMETIC AKT INHIBITORDisclosed herein is a species of peptide and non-peptide inhibitors of Akt, an oncogenic protein. Beginning with a residue of Akt target substrate GSK-3, the functional domains of the GSK-3 residue we..INHIBITION OF SHP2/PTPN11 PROTEIN TYROSINE PHOSPHATASE BY NSC-117199 AND ANALOGSProtein tyrosine phosphatase (PTP) Shp2 is a non-receptor PTP that involved in cell signaling and regulation of cell proliferation, differentiation, and migration. Shp2 mediates activation of kinases ..BIVM (BASIC, IMMUNOGLOBULIN-LIKE VARIABLE MOTIF-CONTAINING) GENE, TRANSCRIPTIONAL PRODUCTS, AND USES THEREOFThe subject invention provides polynucleotide sequences, designated BIVM, and transcriptional/translational products obtained from the polynucleotide sequences of the invention. The subject invention ..STAT3 Agonists and Antagonists and Therapeutic Uses ThereofThe present invention relates to methods for modulating, i.e., agonizing or antagonizing, Stat3 (Signal Transducer and Activator of Transcription3) signaling activity for use in gene therapy. Inhibiti..Protein kinase C as a target for the treatment of respiratory syncytial virusThe subject invention concerns a method of inhibiting respiratory syncytial virus (RSV) infection in a patient by decreasing the endogenous protein kinase C (PKC) activity within the patient. Preferab..DETECTION OF PKC-IOTA AS A BIOMARKER FOR BRAIN TUMORIGENESISA method of detecting brain tumorigenesis in a subject, the method including the steps of (a) obtaining a sample from the brain of the human subject, (b) detecting quantitatively or semi-quantitativel..METHOD OF SELECTIVELY INHIBITING PKCIOTAPKCiota inhibitor1 H-imidazole-4-carboxamide, 5-amino-1 -[2,3-dihydroxy-4-[(phosphonooxy) methyl] cyclopentyl] -,[1 R-(1a, 2ss, 3 ss, 4 a)], (ICA-1 ), targets a unique sequence (amino acid residues 46..SHIP INHIBITION TO DIRECT HEMATOPOIETIC STEM CELLS AND INDUCE EXTRAMEDULLARY HEMATOPOIESISThe present invention concerns inhibition of SHIP expression and/or function in mammalian subjects to direct HSC from the bone marrow to other sites in the body (such as the spleen and/or liver), wher..Passive Electric Field Focus System for In Vivo and In Vitro ApplicationsThe present invention provides a system and method of directing, focusing, or concentrating electrical charges within a defined electric field so that these charges can be used to exert forces on cell..METHODS AND COMPOSITIONS FOR REDUCING ACTIVITY OF THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR AND FOR TREATMENT OF DISEASESMethods, compositions and devices are provided by the present invention for reducing activity of a natriuretic peptide receptor and other signals. Therapeutic treatments are provided by use of polynuc..METHOD AND COMPOSITION FOR MODULATING CANONICAL WNT PATHWAY USING FOLATE AND INOSITOLThe canonical Wnt signaling pathway is implicated in many disorders including neural tube defects, limb malformations, and heart defects, developmental disorders associated with alcohol exposure (feta..HYPERACTIVE VARIANTS OF 5-AMINOLEVULINATE SYNTHASE AND METHODS OF USEThe rate of porphyrin biosynthesis in mammals is controlled by the activity of the pyridoxal 5'-phosphate-dependent enzyme 5-aminolevulinate synthase. Assuming the turnover in this enzyme is controlle..ALPHA-HELIX MIMETIC USING A 2,5-OLIGOPYRIMIDINE SCAFFOLDAlpha-helix mimetics and associated methods of making are provided. These compounds are constructed using a 2,5-oligopyrimidine scaffold. The semi-rigid scaffold holds individual side chain-like resid..Growth Factor Binding MoleculesGrowth factor binding molecules having a plurality of peptide loops attached to a non-peptide organic scaffold, preferably having pseudo-six amino acid peptide loops with four amino acid sidechains. T..VOLUME EXCLUSION AGENT TO ENHANCE FORMATION OF EXTRACELLUAR MATRIXA method of enhancing the formation of extracellular matrix in culture. Cells in culture secrete most of the collagen into the media as unprocessed procollagen, i.e., the cells do not convert procolla..INHIBITION OF CELL PROLIFERATIONCompounds of formula (I) and (II) are provided as modulators of Rb:Raf-1 interactions which are potent, selective disruptors of Rb:Raf-1 binding. Therapeutic methods of using the compounds, for exampl..AKT AND CLUSTERIN AS BIOMARKERS OF CHEMOTHERAPEUTIC RESPONSIVENESSCompositions and methods for identifying cancers resistant to treatment due to the presence of elevated pAKT levels and/or overexpression of AKT. The methods comprise the detection of active phosphory..MATERIALS AND METHODS FOR PREVENTING OR TREATING NEURODEGENERATIVE CONDITIONS ASSOCIATED WITH ABETA PEPTIDE ACCUMULATIONThe subject invention concerns methods for preventing and/or treating neurodegenerative conditions associated with Abeta peptide accumulation in neural tissue in a human or animal. The subject inventi..METHOD OF ACTIVATING NK CELLSThe present invention provides a method of mediating hypo-activation of NK cells. Methods of the present invention comprise administering to a subject an effective amount of broad acting phosphotase i..METHOD OF MODULATING SHIP ACTIVITYA method of treating or preventing an immune disorder, such as graft versus host disease, in a subject. The method includes the administering a SHIP1 inhibitor, such as 3a-aminocholestane, to a subjec..Cytotoxin Compound And Method of IsolationThe present invention concerns compounds derived from tunicates of the species Synoicum adareanum, as well as to pharmaceutical compositions comprising these compounds and methods of use. Extracts fro..Immunotherapy for Treatment of Amyloid-Related Disorders Using Encapsulated Beta-Amyloid PeptidesThe present invention relates to the field of polymer chemistry and more particularly to encapsulated peptides and uses thereof.HUMAN MAST CELL LINE AND USES THEREOFThe subject invention pertains to the development of a novel human mast cell line, USF-MC1. USF-MC1 is a mast cell precursor present in human umbilical cord blood (HUCB) that may be sustained in cultu..INDOLINE SCAFFOLD SHP-2 INHIBITORS AND METHOD OF TREATING CANCERProtein tyrosine phosphatase (PTP) Shp2 is a non-receptor PTP that involved in cell signaling and regulation of cell proliferation, differentiation, and migration. Shp2 mediates activation of kinases ..CANCER TREATMENT USING NATRIURETIC PEPTIDESThe present invention includes a method of utilizing four peptide hormones to inhibit the growth of cancer(s). A dramatic decrease in the number of human pancreatic adenocarcinoma cells (i.e., the typ..DENDROASPIS NATRIURETIC PEPTIDE FOR TREATMENT OF CANCERDisclosed is a method of inhibiting the growth of a cancer cell using Dendroaspis natriuretic peptide (DNP), isolated from the Green Mamba snake venom with similar structure to ANP, with or without fo..Inhibition of SHIP to Enhance Stem Cell Harvest and TransplantationThe instant invention teaches the inhibition of SHIP expression, or function for the increased efficacy of autologous stem cell transplants. In another embodiment, interference with SHIP function can ..ANTIVIRAL ACTIVITY OF CYCLOPENTENE NITRO-ESTER AND DERIVATIVESDisclosed is a method of synthesizing new optically pure heterocyclic compounds using Pd(0) catalyzed intramolecular cyclizations. Analogs of cyclopentanes, like isoxazoline-2-oxide and furan, with si..SHIP-Deficiency to Increase Megakaryocyte Progenitor ProductionThe invention concerns a method for increasing megakaryocyte and megakaryocyte progenitor numbers in vitro or in vivo by suppressing SH2-containing inositol-5-phosphatase (SHIP) function in megakaryoc..PLATINUM COMPLEXES AND METHODS OF USEThe subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat..METHODS FOR INHIBITING TUMOR CELL PROLIFERATIONThe subject invention concerns methods for inhibition of STAT biological functions using platinum complexes.PREDICTIVE VALUE OF NUCLEAR EXCISION REPAIR GENES FOR CANCER SURVIVALPatients who have their cancer surgically removed are at risk for recurrence, even though currently free of disease. Lung cancer patients with higher activity of a nuclear excision repair gene called ..Lysophospholipids as biomarkers of ovarian cancerA method of using a bioactive lysophospholipid (LL) as a biomarker for detecting the presence and recurrence of ovarian cancer. Subspecies of LL, such as lysophosphatidic acid (LPA), lysophosphatidyli..DNA Biochip and methods of useThe subject invention concerns materials and methods for detecting nucleic acid sequences. One aspect of the invention concerns a silicon-based "biochip" comprising nucleic acid immobilized thereon. I..CANCER PLATINUM RESISTANCE DETECTION AND SENSITIZATION METHODThe phosphorylation status of the BAD protein is a determinant of ovarian cancer cell responsiveness to platinum chemotherapy. Indirect manipulation of BAD phosphorylation status influences cisplatin ..AUTOMATED PARTICULATE CONCENTRATION SYSTEMAn automated system for concentrating potentially harmful substances from various water types or other non-viscous liquids to facilitate detection of those substances is disclosed herein. The automate..Cannabinoid 2 (Cb2) Receptor Gene Promoter and Unique RNA Transcripts in B Cells and Methods of UseCannabinoid receptor 2 (CB2) is expressed in B lymphocytes and is involved in immune regulation. Mouse splenic B cells express three CB2 transcripts utilizing two different first exons. Human peripher..Oncotherapeutic Application of Inhibitors of High-Affinity Glucose TransportersThe subject invention concerns materials and methods for treating oncological disorders in a person or animal using any agent or compound that inhibits uptake of glucose into a cell. The subject inven..BIOMARKERS FOR PREDICTING RESPONSE TO IMMUNOSUPPRESSIVE THERAPYThe subject invention concerns methods and materials for assessing a patient's likelihood of responsiveness to an immunosuppressive therapy. The subject invention is contemplated for use with patients..MICROFLUIDIC DEVICE FOR CONTROLLED AGGREGATION OF SPIDER SILKThe present invention is directed to a device and method of controlling the phase separation of one or a mixture of two or more spider silk proteins, leading to the defined and controllable assembly o..METAL-ENHANCED BIOLUMINESCENCE: AN APPROACH FOR MONITORING BIOLOGICAL BIOLUMINESCENT PROCESSESThe present invention relates to surface plasmon-coupled bioluminescence, wherein bioluminescent emission from a bioluminescent chemical reaction couples to surface plasmons in metalized particles the..HIGH AFFINITY RECOMBINANT SEA LAMPREY ANTIBODIES SELECTED BY A YEAST SURFACE DISPLAY PLATFORMThe present invention relates to a Yeast Surface Display (YSD) vector for expression of VLR proteins by yeast, wherein the vector includes nucleotide sequences encoding segments of yeast flocculation ..ENGINEERING BROAD-SPECTRUM DISEASE RESISTANCE AGAINST HAUSTORIUM-FORMING PATHOGENS USING RPW8 AS A DELIVERY VEHICLEThe present invention relates to the increased expression of RPW8 proteins causing an increased level of the RPW8 proteins at extrahaustorial membrane with subsequent induction of pathogen inhibition ..ELECTROADDRESSING AND IN-FILM BIOPROCESSING USING STIMULI-RESPONSIVE HYDROGEL-FORMING POLYMERSMethods for the generation of hydrogels formed by electrodeposition of an electroaddressable polymer are described. The hydrogels may contain one or more cell populations electroaddressed or electroad..UBIQUILIN REGULATION OF PRESENILIN ENDOPROTEOLYSIS, AND SUPPRESSION OF POLYGLUTAMINE-INDUCED TOXICITY IN CELLSUse of ubiquilin is described, including utilization for reducing fragmentation of presenilin 1 and 2 and to modulate [gamma]-secretase components, Pen-2 and Nicastrin, as well as utilization for indu..PROTEINS CONTAINING EXPANDED POLYGLUTAMINE TRACTS INDUCE MITOCHONDRIAL FRAGMENTATION BY DISRUPTING MITOCHONDRIAL FUSIONExpanded polyglutamine tracts are shown to be a cause of disturbance of mitochondrial function and therefore a cause of cell toxicity and cell death and a cause of various diseases or disorders relate..Recombinant Double-Stranded RNA Phage, and Use of the SameA recombinant double stranded RNA (dsRNA) phage expresses dsRNA-encoded genes in eukaryote cells. Recombinant dsRNA phage are useful for the expression of dsRNA expression cassettes encoding passenger..TARGETED DELIVERY OF IMAGING PROBES FOR IN VIVO CELLULAR IMAGINGThe present invention relates to imaging probes comprising immunoliposomes that encapsulate self-quenching concentrations of stable free radicals or high-relaxivity contrast agents, such as nitroxides..IMPROVED FOLDING OF RECOMBINANT PROTEINS VIA CO-EXPRESSION OF ARCHAEAL CHAPERONESThe present invention relates to recombinant protein production, and more specifically, to methods for recovery of properly folder bioactive proteins by expressing chaperone genes from extremophilic A..FIBROUS ASSEMBLIES FOR ANTIBODY PRESENTATION, AND MULTIPLEXED ANTIGENIC ANALYSIS USING SAMEBiofunctionalized fibers including a fiber platform and a histidine-tagged protein and, optionally, an antibody. Chitosan is a fiber useful as the fiber platform. The fiber platform may be treated wit..BIOSYNTHETIC PATHWAY AND GENES REQUIRED FOR TROPODITHIETIC ACID BIOSYNTHESIS IN SILICIBACTER TM1040Production and use of a sulfur-containing compound, tropodithietic acid (TDA), from the roseobacter Silicibacter sp. TM1040 is described. Specifically, a biosynthetic and regulatory pathway for TDA bi..RADIATION-RESISTANT MUTANTS OF A HALOPHILIC ARCHAEON AND USES THEREOFThe present invention relates to variants of the model halophile Halobacterium sp. NRC- 1 that have been exposed to cycles of irradiation with high doses of 18-20 MeV electrons. These novel isolated h..CONVERSION OF JUST-CONTINUOUS METALLIC FILMS TO LARGE PARTICULATE SUBSTRATES FOR METAL-ENHANCED FLUORESCENCEThe present invention relates to a method of producing silver films having large nanoparticles caused by cracking during anaerobic annealing to provide surfaces that exhibit increased metal enhanced f..VOLTAGE-GATED METAL-ENHANCED FLUORESCENCE, CHEMILUMINESCENCE OR BIOLUMINESCENCE METHODS AND SYSTEMSIn the present invention, it is demonstrated for the first time, the influence of electrical current on the ability of surface plasmons to amplify fluorescence signatures. An applied direct current ac..MICROWAVE TRIGGER METAL-ENHANCED CHEMILUMINESCENCE (MT MEC) AND SPATIAL AND TEMPORAL CONTROL OF SAMEThe present invention relates to a method of imaging structures and features using plasmonic emissions from metallic surfaces caused by chemiluminescence based chemical and biological reactions wherei..PLANTS WITH REDUCED EXPRESSION OF PHOSPHATASE TYPE 2C GENE FOR ENHANCED PATHOGEN RESISTANCEThe present invention relates to a method for down regulating an Arabidopsis protein phosphatase type 2C gene, referred to as "defense-associated protein phosphatase type 2C one" (DAPP1) that function..GLYCOSYLATION ENGINEERED ANTIBODY THERAPYThe instant invention is drawn to methods of generating a glycosylation- engineered antibody, and using the glycosylation-engineered antibody for treating a patient, particularly a cancer patient or a..A NOVEL COMPOSITION OF MATTER AND METHOD FOR STIMULATING THE GROWTH OF BENEFICIAL MICROORGANISMSThe invention describes a novel composition of matter obtained from the leaves of green plants, which is useful in promoting the growth of beneficial microorganisms. Specifically, that the invention d..COMPOSITIONS AND METHODS UTILIZING FIBRIN BETA CHAIN FRAGMENTS OF THE BBETA CHAIN OF FIBRINOGENA composition including a peptide sequence of the formula ssX1-X2, the peptide sequence corresponding to an amino acid sequence of a fibrin beta chain fragment of a Bbeta chain of fibrinogen, wherein ..ZAP-70 AS PREDICTOR AND MODULATOR OF EFFECTOR FUNCTION OF T CELLSIn this application is described a novel, multiparameter analysis of TCR-coupled signaling and function in resting and activated naive and memory CD4 T cells, revealing a biochemical basis for immunol..ERG-1 Peptides and Polynucleotides and Their Use in the Treatment and Diagnosis of DiseaseThe present invention relates to peptide and polynucleotide fragments of ERG-1, and in particular, human ERG-1a (HERG-1a) and its isoforms, and their use in the treatment and diagnosis of disease, esp..COMPOSITIONS AND METHODS OF USE OF EPB1, AND ERBB3 BINDING PROTEINInhibition of the proliferation of hormone refractory prostate cancer cells is achieved by administering EPB1, an ErbB3 binding protein, in combination with another anti-proliferation therapy such as ..Vaccines and Immunomodulatory Therapies for TularemiaThe present invention relates to attenuated strains of Francisella tularensis from which genes in the guanine nucleotide biosynthetic pathway have been deleted and to methods for making the mutants. T..MICROCIN H47 PLASMID SELECTION SYSTEMThe present invention relates generally to stabilized expression plasmid systems. The stabilized expression plasmid systems comprise an expression vector that includes a plasmid maintenance system (PM..Breast cancer resistance protein (BCRP) antibodiesThe Breast Cancer Resistance Protein is described, as well as the cDNA encoding said protein. This protein has been found to confer resistance to cancer chemotherapeutic drugs.Novel Antiproliferative Factor and Methods of UseA novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and r..IMMUNOGLOBULIN CONSTANT REGION FC RECEPTOR BINDING AGENTS.IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each repla..RAPID EXPRESSION CLONING OF HUMAN MONOCLONAL ANTIBODIES FROM MEMORY B CELLSThe present application provides methods for producing human monoclonal antibodies without using hybridoma technology, antibodies produced used the described methods, and methods for using the antibod..FACTOR VIII COMPOSITIONS AND METHODSThe present invention provides methods of increasing the half-life and/or specific activity of factor VIII. More specifically, the invention provides methods of increasing the half-life and/or specifi..NOVEL HUMAN ANDROGEN RECEPTOR ALTERNATIVE SPLICE VARIANTS AS BIOMARKERS AND THERAPEUTIC TARGETSThe present invention relates to novel androgen receptor splice variants (AR3, AR4, AR4b, AR5 and AR8) and variants and fragments thereof which have a role in the progression of androgen independent p..COMPOSITIONS AND METHODS FOR THE INNATE IMMUNE RESPONSE PATHWAYAutoimmune diseases are the consequence of complex interactions between a mosaic of host genetic factors and etiologic elements. Celiac disease (CD) is an autoimmune disease prevalent in 1% of the gen..METHODS FOR TREATING CANCERS AND DISEASES ASSOCIATED WITH 4-1BB (CD137) EXPRESSIONThe present invention relates to the role of 4-1BB (CD137) ligand and anti-4-1BB (CD137) antibody in the treatment of cancers and diseases associated with 4-1BB (CD137) expression. More particularly, ..ENGINEERED TYPE IV PILIN OF CLOSTRIDIUM DIFFICILEThe present invention relates to engineered Clostridium difficile type IV pilin (tfp) genes, type IV pilin proteins which can serve as a diagnostic marker for identification of patients infected with ..CO-SIGNALING METHODS FOR TREATING CANCERSProvided herein is a method of treating a neoplastic disease in an individual in need of such treatment, comprising the steps of: expanding ?d T lymphocytes in vitro; priming Natural Kill cells in vit..MAGE-A3/HPV 16 PEPTIDE VACCINES FOR HEAD AND NECK CANCERThe present invention relates to Trojan antigens, and immunogenic compositions comprising the Trojan antigens. The present invention also relates to methods of generating an immune response in a subje..TARGETING NAD BIOSYNTHESIS IN BACTERIAL PATHOGENSThe emergence of multidrug-resistant pathogens necessitates the search for new antibiotics acting on previously unexplored targets. Nicotinate mononucleotide adenylyltransferase of the NadD family, an..Antigen binding domains from fishA process for the production of an antigen specific antigen binding domain using a transformed host containing an expressible DNA sequence encoding the antigen specific antigen binding domain, wherein..RESPONSE GENE TO COMPLEMENT 32 (RGC-32) IN DISEASEThe invention relates to antibodies that bind to a fragment of the Response Gene to Complement-32 (RGC-32), as well as methods of using these antibodies. Particular methods of using the antibodies of ..NOVEL RETINAMIDE RETINOIC ACID METABOLISM BLOCKING AGENTSRetinoic acid metabolism blocking agents (RAMBAs). The RAMBAs may be used for treatment of cancer, including breast and prostate cancers. Methods for preparing novel retinamide RAMBAs. The methods inc..NON-HEMOLYTIC CLYA FOR EXCRETION OF PROTEINSThe disclosure below provides a protein export system utilizing non-hemolytic variants of HlyE family member proteins for efficiently producing recombinant protein from a host cell. In a preferred emb..FLUORESCENT PROTEINS AND USES THEREOFThe present invention provides novel fluorescent proteins. In particular aspects of the invention, a novel fluorescent protein of the invention has an increase in quantum yield. In other particular as..ANDROGEN RECEPTOR INACTIVATION CONTRIBUTES TO ANTITUMOR EFFICACY OF CYP17 INHIBITORS IN PROSTATE CANCERProvided are methods of inhibiting CYP17 in a mammal, such as a human, that include administering an effective amount of at least one CYP17 inhibitor, such as VN/124-1, VN/125-1, VN/85-1, VN/87-1 and/..METHODS AND SYSTEMS FOR PURIFYING TRANSFERRING AND/OR MANIPULATING NUCLEIC ACIDSThe disclosure provides methods, systems, and devices for purifying, transferring or manipulating nucleic acids while maintaining the 2D spatial relationship of the nucleic acids as they were present ..ENHANCED CELLULASE EXPRESSION IN S. DEGRADANSThe invention provides organisms and methods of using and making organisms with enhanced cellulase expression.PEPTIDES FOR TRANSPORT OF THERAPEUTICS AND THEIR CARRIERS IN MOUSE MODELS AND HUMANSA system for targeted delivery of agents (e.g., molecular probes, diagnostic agents, therapeutic agents, imaging agents, research or analytical compounds, enzymes, peptides, proteins, lipids, lipoprot..Process For The Preparation of Beta and Alpha CryptoxanthinThe present invention relates to a process for converting lutein and/or lutein esters to (3R)-[beta]-cryptoxanthin and (3R,6'R)-[alpha]-cryptoxanthin, suitable for human consumption as dietary supplem..ENGINEERED PROTEASES FOR AFFINITY PURIFICATION AND PROCESSING OF FUSION PROTEINSThe present invention is directed to the identification of a protease prodomain that is capable of binding a corresponding protease with high affinity. The protease prodomain of the present invention ..RADIOACTIVELY MARKED CYCLOPROPANE DERIVATIVES OF DAT AFFINE TROPANESThe invention relates to radioactively marked cyclopropane derivatives of DAT affine tropanes suitable for the quantitative, non-invasive imaging of striatal and extrastiatal dopamine transporters (DA..APPARATUS, METHOD, AND GEL SYSTEM FOR ANALYTICAL AND PREPARATIVE ELECTROPHORESISThe present invention relates to an electrophoresis apparatus comprising a gel chamber for receiving electrophoresis medium, a removable gel system, which is arranged in the gel chamber, having a sepa..Active Microfluidic MembranesThe present invention relates to a biofabricated Active Microfluidic Membrane (AMM) in a microfluidic network of a microfluidic device and a method for the in situ biofabrication of such a microfluidi..SPARSELY CROSS-LINKED NANOGELS: A NOVEL POLYMER STRUCTURE FOR MICROCHANNEL DNA SEQUENCINGThe present invention is generally directed to novel polymeric materials for use in the electrophoretic separation of nucleic acids. In particular, the novel polymer materials are sparsely crosslinked..Peptides, Peptidomimetics and Small Molecule Inhibitors of the Epstein-Barr Virus Mediated Fusion and Entry ProcessDisclosed are compositions and methods for modulating Epstein-Barr virus (EBV) infection in a patient. The compositions may include peptides or peptidomimetics that are related to gp42 and function to..SELF ASSEMBLING PEPTIDE SYSTEMS AND METHODSThe present invention provides a self-assembling peptide system which utilizes a bioactive sequence which enhances transfection efficiency. In particular, the present invention provides compositions a..SYNTHETIC PEPTIDE AND PEPTIDE CONJUGATES AND RELATED TISSUE COUPLING METHODS VIA TRANSGLUTAMINASE ENZYMEPeptides and conjugates thereof comprising one or more bioactive agents which can be coupled to a tissue via a transglutaminase and related methods.COMPOSITION AND METHOD FOR SELF-ASSEMBLY AND MINERALIZATION OF PEPTIDE-AMPHIPHILESThe present invention is directed to a composition useful for making homogeneously mineralized self assembled peptide-amphiphile nanofibers and nanofiber gels. The composition is generally a solution ..CITRIC ACID POLYMERSThe present invention provides polymers (e.g., elastomeric citric acid polymers) and methods of making and using these polymers (e.g., as a biologically active molecule delivery platform). In certain ..METHODS AND COMPOSITIONS FOR GENERATING SPORULATION DEFICIENT BACTERIAThe present invention relates to methods and compositions for engineering sporulating bacterial cells, particularly a cell of the class Clostridia. In particular, the present invention relates to the ..ANTI-CANCER COMPOUNDSThe present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound ..Novel Biodegradable Elastomeric Scaffold for Tissue Engineering and Light Scattering Fingerprinting Methods for Testing the SameThe present invention is directed to a novel biocompatible polymer that may be used in tissue engineering. More specifically, the specification describes methods and compositions for making and using ..POTENT AND SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE INHIBITORS WITH IMPROVED MEMBRANE PERMEABILITYCompounds and related compositions and methods as can be used to inhibit neuronal nitric oxide synthase and as can be employed in the treatment of various neurodegenerative diseases.COMPOSITIONS AND METHODS FOR INDUCTION OF ANTIGEN-SPECIFIC TOLERANCEThe present invention utilizes carrier particles to present antigen peptides and proteins to the immune system in such a way as to induce antigen specific tolerance. The carrier particle is designed i..METHOD OF MODULATING HSF-1The present invention is directed to methods of modulating HSF1 activity comprising modifying the acetylation of the DNA binding domain of the HSF1.Cysteine Protease Autoprocessing of Fusion ProteinsDisclosed are fusion proteins, polynucleotides that encode the disclosed fusion proteins, and methods for expressing and autoprocessing of the disclosed fusion proteins to obtain a target protein. The..MANIPULATION OF NEURONAL ION CHANNELSThe present invention provides compositions and methods for the manipulation of ion channels. For example, the present invention relates to Parkinson's and other neurological diseases and conditions, ..POLYVALENT RNA-NANOPARTICLE COMPOSITIONSThe present invention concerns nanoparticles functionalized with duplex RNA for a variety of uses, including but not limited to gene regulation. More specifically, the disclosure provides a new strate..TARGET DNA INTERFERENCE WITH crRNAThe present invention provides methods, systems, and compositions for interfering with the function and/or presence of a target DNA sequence in a eukaryotic cell (e.g., located in vitro or in a subjec..METHODS AND COMPOSITIONS FOR ISOLATING NUCLEIC ACIDThe present invention relates to compositions and methods for isolating and purifying nucleic acid. In particular, the present invention relates to methods of isolating nucleic acid from cells for use..INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASISThe present invention provides compounds and methods of inhibiting and treating metastatic prostate cancer. The compounds include MEK4 inhibitors. In another aspect the invention provides methods of i..LATERAL FLOW STRIP AND USES THEREOFThe present invention relates to lateral flow strip assay system and uses thereof. In particular, the present invention relates to lateral flow assay systems for the simple and inexpensive detection o..NOVEL PEPTIDE-BASED SCAFFOLDS FOR CARTILAGE REGENERATION AND METHODS FOR THEIR USEDisclosed herein are novel peptide amphiphile molecules and compositions composed of a peptide sequence that non-covalently binds the growth factor TGF-ss1. Also disclosed are methods of using these p..MULTIPLEXED BIOMOLECULE ARRAYS MADE BY POLYMER PEN LITHOGRAPHYMethods of patterning multiple biomolecules on a surface are disclosed. The method includes inking a polymer pen array, where tips are inked with selected inks comprising the biomolecules, and transfe..INTERPENETRATING BIOMATERIAL MATRICES AND USES THEREOFThe present invention relates to matrices (e.g., fibrin-alginate matrices; fibrin-alginate-matrigel matrices) for culture of cells, organs (e.g., ovary or fragment thereof), cells and cell aggregates ..BIOMARKERS FOR PROSTATE CANCERThe present invention relates to compositions and methods for the detecting, treating, and empirically investigating the prostate. In particular, the present invention provides compositions and method..METHODS FOR NUCLEIC ACID TRANSFER INTO CELLSThe present invention provides methods for increasing the transfer of nucleic acids into cells. In particular, the present invention provides for the use of inhibitors of HDAC6, a cytoplasmic histone ..NON-ENZYMATIC DETECTION OF BACTERIAL GENOMIC DNAThe present invention relates to methods for detecting for the presence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to a method that ut..Self-Assembly of Peptide-Amphiphile Nanofibers Under Physiological ConditionsPeptide amphiphile compounds, compositions and methods for self-assembly or nanofibrous network formation under neutral or physiological conditions.DETECTION OF MATERNAL ALCOHOL EXPOSUREThe present invention provides methods, compositions, and systems for detecting in utero alcohol exposure by detecting expression level changes in certain biomarkers (e.g., in placental tissue). In ce..ALLELIC DISORDERS CAUSED BY MUTATIONS IN TRPV4The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily V, member 4 (TRPV4). In particular, mutations are detec..SURFACE-IMMOBILIZED ANTIMICROBIAL PEPTOIDSImmobilizable antimicrobial compounds incorporating antimicrobial and/or antifouling components, as can be adhered to various device structures and components.Self-assembling peptide amphiphiles and related methods for growth factor deliveryThe invention provides peptides that are capable of binding growth factors, as well as peptide amphiphiles comprising certain of these peptides, micellar assemblies of such amphiphiles and related met..LABEL-FREE BIOSENSORS BASED UPON DISTRIBUTED FEEDBACK LASERA biosensor based upon a vertically emitting, distributed feedback (DFB) laser is disclosed. In one configuration, the DFB laser comprises a replica-molded, one- or two- dimensional dielectric grating..Altered Intracellular Localization of BRK/Sik Protein Tyrosine Kinase in Human Prostate TumorsThe invention provides methods for detecting abnormal prostate conditions, such as benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN), and adenocarcinoma, in an animal by co..Anti-Antiogenic Fragments of Pigment Epithelium-Derived Factor (PEDF)The present invention provides anti-angiogenic derived from pigment epithelium-derived factor (PEDF) pharmaceutical compositions comprising the peptides, and methods of preventing angiogenesis. Such m..THREE-DIMENSIONAL MICROFABRICATED BIOREACTORS WITH EMBEDDED CAPILLARY NETWORKIn an aspect, the present invention uses projection micro stereolithography to generate three-dimensional microvessel networks that are capable of supporting and fostering growth of a cell population...NEUTRALIZATION OF STAPHYLOCOCCAL AND STREPTOCOCCAL TOXINSStaphyloccocus and Streptococcus bacteria secrete various toxins that act as superantigens by stimulating a large fraction of the host's T cells. The binding of toxins to the variable domains of T cel..PEPTIDES AND REGULATION OF CALCIUM CHANNELSCalcium channels can be regulated by natural gamma proteins. Herein we disclose embodiments of compositions and methods, particularly involving short peptides which are capable of regulating calcium c..RHO1-Gamma Amino Butyric Acid C Receptor-Specific AntibodiesThis invention provides antibodies immunologically specific for rho1-GABAC receptor protein. The invention also provides methods of making and methods of using said antibodies and kits containing the ..Production of Neural Stem Cells from Bone Marrow Tissue and Use ThereofThe invention provides reagents and methods for preparing mammalian mesenchymal-derived neural stem cells, especially autologous mesenchymal-derived neural stem cells, compositions thereof, and method..USES OF BISPECIFIC ANTIBODY COATED DENDRITIC CELLS PULSED WITH ANTIGENS AND GM-CSF IN IMMUNE REGULATIONGM-CSF administered before immunization exerted a sustained suppressive effect against the induction of myasthenia gravis (MG). This suppression was associated with lowered serum autoantibody levels, ..METHOD OF PROMOTING NEUROGENESIS BY MODULATING SECRETASE ACTIVITIESThis invention provides methods and reagents for promoting neurogenesis, by modulating neural stem cell proliferation and differentiation. Particularly, this invention provides methods and reagents fo..COMPOSITIONS AND METHODS TO PREVENT CANCER WITH CUPREDOXINSThe present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains deri..HEMICELLULOSE-DEGRADING ENZYMESThe present disclosure provides methods for the conversion of hemicellulose into fermentable sugars using enzymes isolated from Prevotella bryantii. Hemicellulose-degrading enzymes include an endoxyla..DESIGN, SYNTHESIS AND EVALUATION OF PROCASPASE ACTIVATING COMPOUNDS AS PERSONALIZED ANTI-CANCER DRUGSCompositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of com..STIMULI-RESPONSIVE LOW SOLUBILITY HYDROGEL COPOLYMERS OF N-ISOPROPYL ACRYLAMIDE AND SYNTHESIS METHODPreferred embodiment stimuli-responsive low solubility copolymer hydrogel compositions of the invention include polymerized N-isopropylacrylamide and water insoluble monomer or oligomer repeating unit..INFERTILITY ASSOCIATED DEFB-126 DELETION POLYMORPHISMThe present application provides diagnostic methods for determining the fertility status of a male individual by evaluating his DEFB-126 phenotypic and genotypic status. The present invention relates ..HUMAN SINGLE-CHAIN T CELL RECEPTORSA soluble human single-chain T cell receptor (TCR) having the structure: Va2-L-Vss or Vss-L-Va2, wherein L is a linker peptide that links Vss with Va, Vss is a TCR variable ss region, and Va2 is a TCR..Use of polypeptides of cupredoxin family in cancertherapy.Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifyin..COMPOSITIONS AND METHODS FOR INHIBITING Ga PROTEIN SIGNALINGThe present invention comprises compositions and methods for specifically inhibiting signaling through Ga13, Gai and Gaq subunits.ACTIVATED MESENCHYMAL STEM CELLS FOR THE PREVENTION AND REPAIR OF INFLAMMATORY STATESInflammatory cytokines e.g. IFN-? serve as initiating stimuli for MSC immunosuppresive activity in vivo. Other inflammatory cytokines, such as TNF alpha, the molecule hemoxygenase I, and TLR ligation ..REGULATION OF APOPTOSIS BY NEURAL SPECIFIC SPLICE VARIANTS OF IG20Pro-apoptotic signaling caused by down-modulation of KIAA0358 or expression of IG20-SV4 effectively induces spontaneous apoptosis and sensitization to TNFa-induced apoptosis in neuroblastoma cells. Me..Fitness assay and associated methodsThe present invention provides an assay for determining the biochemical fitness of a biochemical species in a mutant replicating biological entity relative to its predecessor. The present invention fu..Soybean Gene for Resistance to Aphis glycinesAn Aphis glycines resistance Rag2 gene is provided herein, along with methods for identifying its presence using marker-assisted selection. A cultivar of G. max having resistance to Aphis glycines con..PAK1 AGONISTS AND METHODS OF USEThe present invention is directed to Pak1 agonists and methods of use.High affinity TCR proteins and methodsT cell receptors (TCRs) that have higher affinity for ligand than wild type TCRs are provided. These high affinity TCRs are formed by mutagenizing a T cell receptor protein coding sequence to generate..Method for modulating or controlling sodium channel current by reactive oxygen species (ROS) originating from mitochondriaMethod for modulating or controlling sodium channel current of a cell includes inducing mitochondrial reactive oxygen species (ROS) production in the cell.IDENTIFICATION AND USE OF PEPTIDE INHIBITORS OF PROTEIN SYNTHESISThe present invention discloses compositions of peptide inhibitors of protein synthesis, and methods of identifying peptide inhibitors that are capable of inhibiting protein synthesis through an inter..HYPERVIRULENT MUTANT OF AGROBACTERIUM TUMEFACIENSThis disclosure relates to a mutant Agrobacterium tumefaciens that is functionally deleted for the atu1060 gene that codes for the cyclic di-GMP synthase Atu1060, as well as methods for its use in tra..Immunogenic Mycoplasma Hyopneumoniae PolypeptidesMycoplasma hyopneumoniae polypeptides and nucleic acids, as well as nucleic acid expression vectors and host cells containing nucleic acid vectors are provided. In addition, compositions containing M...Metacaspase II in engineering soybean for disease resistanceThe present invention is in the field of soybean genetics. More specifically, the invention relates to nucleic acid molecules from regions the soybean genome, which are associated with soybean Phytoph..USE OF RPA4 AND RPA4/RPA32 HYBRID POLYPEPTIDES FOR MODULATING CELL PROLIFERATIONDisclosed are polynucleotides and polypeptides that are useful for modulating cell proliferation. The polynucleotides may comprise coding regions for RP A4 and RPA4/RPA32 hybrid polypeptides. The poly..IMMUNOGENIC COMPOSITIONS FOR ACTIVATING ?d T CELLSDisclosed are compositions, kits, and methods for activating, expanding, or stimulating ?d T cells that include recombinant attenuated microbes. The compositions may include pharmaceutical composition..ZINC FINGER NUCLEASE FOR THE CFTR GENE AND METHODS OF USE THEREOFThe present invention provides new zinc finger proteins and zinc finger nuclease (ZFNs) that find particular using in repairing the cystic fibrosis transmembrane conductance regulator (CFTR) gene.Direct Oxidation of Calcium/Calmodulin Dependent Protein Kinase II and Associated Diagnostic and Therapeutic MethodsCalcium/calmodulin dependent protein kinase II (CaMKII) has been found to be directly oxidized, and direct oxidation of CaMKII was observed to result in calcium independent activation of CaMKII. Antib..IMMUNOSTIMULATORY NUCLEIC ACIDSThe invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25% T nucleotide ..VARIANT TLR4 NUCLEIC ACID AND USES THEREOFThe invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.HUMAN PROTEIN ACYL TRANSFERASES AND METHODS OF USES THEREFORThe present invention provides the identification of human Ras palmitoyl acyl transfersase complexes, and nucleic acids coding therefor. In addition, methods of screening for modulators of human Ras p..SCHWEINFURTHINS AND USES THEREOFDisclosed is a method for preventing or treating an undesirable condition in a subject carrying cells homozygous null for the neurofibromatosis type 1 gene or subjects that are haploinsufficient for t..BACULOVIRUSES WITH ENHANCED VIRION PRODUCTION AND A METHOD FOR THE PRODUCTION OF BACULOVIRUSESA method of co-expressing a portion of the VSV G protein gene or a truncated "stem" portion with GP64 and a retrovirus increases the titer of retroviral vectors. A truncated VSV G protein, preferably ..LONG ACTING ATRIAL NATRIURETIC PEPTIDE (LA-ANP) AND METHODS FOR USE THEREOFMaterials and methods related to making and using natriuretic polypeptides having a mutation that results in an extended carboxy terminus.COMBINATION MOTIF IMMUNE STIMULATORY OLIGONUCLEOTIDES WITH IMPROVED ACTIVITYA class of immunostimulatory nucleic acids having at least two functionally and structurally defined domains is provided. This class of combination motif immunostimulatory nucleic acids activates an i..Immunostimulatory nucleic acid moleculesNucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and ..RNA INTERFERENCE SUPPRESION OF NEURODEGENERATIVE DISEASES AND METHODS OF USE THEREOFThe present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.Immunomodulatory oligonucleotidesOligonucleotides containing unthylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response in a subject are disclosed. Also disclosed are therapies for t..SCHWEINFURTHIN ANALOGUESThe invention provides fluorescent schweinfurthin analogs of formula(I) which are useful as probes and for the treatment of cancer and other diseases.PHOSPHORYLATED RECOMBINANT N-ACETYL-alpha-D- GLUCOSAMINIDASE (NaGlu) AND USES THEREOFThe present invention relates generally to phosphorylated recombinant NaGIu fusion proteins, the production of phosphorylated recombinant NaGIu fusion proteins and uses thereof.COMPOSITIONS AND METHODS FOR ENHANCING DISEASE RESISTANCE IN PLANTSCompositions and methods for enhancing disease resistance in plants by modulating levels or activities of GmUBox1 polynucleotides and polypeptides are provided. Transformed plants, plant cells, tissue..ACTIVATION OF HIGH PROTEIN CORN GLUTEN BY PH MODIFICATIONCompositions and methods for inhibiting undesirable plants.DITERPENE MODULATOR OF MACROPHAGE PHAGOSOMAL MATURATIONNovel uses for diterpene modulators of macrophage phagosomal maturation are provided. The diterpene isotuberculosinol is used as an immune modulator, assay for pharmaceutical compositions and an isola..Chimeric infectious DNA clones, chimeric porcine circoviruses and use thereof.Una molécula de ácido nucleico quimérico infecciosa de circovirus porcino (PCV1-2) caracterizada por tener una molécula de ácido nucleico que codifica un PCV1 infeccioso, no patógeno que contien..RAMAN-ACTIVE REAGENTS AND THE USE THEREOFThe present invention provides a new class of Raman-active reagents for use in biological and other applications, as well as methods and kits for their use and manufacture. Each reagent includes a Ram..CHIMERIC INFECTIOUS DNA CLONES OF PORCINE CIRCOVIRUS AND USES THEREOFThe present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisy..Universal and differential serologic assay for swine influenza virusA universal and differential assay kit for the detection of antibodies to swine influenza virus (SIV) in a biological sample comprising SIV non-structural 1 (NS1) protein and SIV nucleoprotein (NP); a..New fusion peptide comprising a coupling of a silencing domain with small molecule peptide aptamer, is androgen receptor inhibitor, useful to treat prostate cancer and benign prostatic hyperplasiaFusion peptide (I) comprising a coupling of a silencing domain with small molecule peptide aptamer, for the inhibition of androgen receptor, is new. - ACTIVITY : Cytostatic. - MECHANISM OF ACTION : An..Cyst nematode resistant transgenic plantsCompositions and methods for providing cyst nematode resistance are provided. One aspect provides transgenic plants or cells comprising an inhibitory nucleic acid specific for one or more cyst nematod..DESIGN, SYNTHESIS AND FUNCTIONAL CHARACTERIZATION OF ROTTLERIN ANALOGSA method of synthesizing rottlerin analogs is described. The synthesis methods described are the first known method of synthesizing rottlerin analogs from commercially-available materials to produce c..Use of methanobactinThe invention provides compositions comprising and methods employing methanobactin, as well as methanobactin synthetase sequences.KIDNEY DERIVED STEM CELLS AND METHODS FOR THEIR ISOLATION, DIFFERENTIATION AND USEThe invention relates generally to methods for isolation and culture of kidney stem cells, cells isolated by the methods, and therapeutic uses for those cells.MULTIPOTENT ADULT STEM CELLS AND METHODS FOR ISOLATIONThe invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provid..ANALYSIS OF BRAIN PATTERNS USING TEMPORAL MEASURESA set of brain data representing a time series of neurophysiologic activity acquired by spatially distributed sensors arranged to detect neural signaling of a brain (such as by the use of magnetoencep..DNA APTAMERSThe present invention relates to rapid diagnosis of Salmonella contamination using DNA aptamers.HIGH THROUGHPUT BIOREACTORA continuous flow bioreactor system that includes a bioreactor, an optional post-bioreactor preparation chamber, a cell sorter, and an optional pre-bioreactor preparation chamber in a closed loop, use..SELECTIVE INHIBITORS OF C-JUN N-TERMINAL KINASESCompositions and methods for treating, preventing, or ameliorating one or more symptoms, disorders, or conditions associated with particular c-Jun N-terminal kinase(s) (JNKs) activity are provided. Co..ANTI-FLAVIVIRUS THERAPEUTICThe present invention relates to anti-flavivirus compounds, including lycorine and derivatives thereof, and their use in treating a subject infected by a flavivirus. The present invention also relates..Homologous Recombination in Multipotent Adult Progenitor CellsThe invention relates to methods of altering gene expression by homologous recombination in a multipotent adult progenitor cell (MAPC). In particular, methods of producing a recombinant MAPC, of corre..NUCLEOTIDE REPEAT EXPANSION-ASSOCIATED POLYPEPTIDES AND USES THEREOFIsolated polypeptides that are endogenously expressed from nucleotide repeat expansions are disclosed. In some cases, the polypeptides include polypeptide repeats. In some cases, the polypeptide repea..NEUROTROPHINS AND USES THEREOFA neurotrophin polypeptide, and a biologically active fragment thereof, are described. Also, methods are disclosed that include providing a composition comprising the neurotrophin polypeptide to a sub..TAL EFFECTOR-MEDIATED DNA MODIFICATIONMaterials and methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; "TALENS") are provided.REDUCING INFLAMMATION USING CELL THERAPYThe invention provides methods for treating pathological conditions associated with an undesirable inflammatory component, including graft- versus -host disease. The invention is generally directed to..HAEMOPHILUS PARASUIS POLYPEPTIDES AND METHODS OF USEThe present invention provides isolated polypeptides having oligopeptide permease activity and an amino acid sequence that has at least 80 % identity with a Haemophilus parasuis OppA polypeptide. Also..DECELLULARIZATION AND RECELLULARIZATION APPARATUSES AND SYSTEMS CONTAINING THE SAMEThe invention described herein provides systems and apparatuses for an initialpreparation of an organ or tissue scaffold comprising an extracellular matrix, and subsequent recellularization of the sca..TREATMENT OF DISEASES CAUSED BY BACTERIAL EXOTOXINSProvided are high affinity T cell receptor variable regions that are useful for treating diseases caused by superantigens including atopic dermatitis, pneumonia and delayed wound healing. The variable..Detection of nucleic and acid sequence differences using the ligase detection reaction with addressable arraysThe present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality o..MAPC GENERATION OF LUNG TISSUEThe present invention relates to methods of improving function in lung tissue by administering a population of multipotent adult progenitor cells ("MAPCs") or differentiated progeny thereof.MODIFIED VITAMIN K-DEPENDENT POLYPEPTIDESThe invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot format..Stem Cell Aggregates and Methods for Making and UsingThe invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stern cells but can differe..MODIFIED VITAMIN K-DEPENDENT POLYPEPTIDESThe invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot format..MOLECULAR MARKERS FOR IDENTIFICATION OF FAT AND LEAN PHENOTYPES IN CHICKENSThe invention provides molecular methods of screening chickens to determine those more likely to have a lean or fat phenotype by identifying the presence of at least one polymorphism in genetic materi..NOVEL HYDROGELS AND USES THEREOFThe present invention provides novel hydrogels and methods of making and using such hydrogels. The present invention provides hydrogels that may be formed by the self-assembly of peptides in solution...INJECTABLE BETA-HAIRPIN PEPTIDE HYDROGEL THAT KILLS METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUSA peptide comprising the sequence VKVKVRVKVDPPTKVKVRVKV-NH2 forms a hydrogel which has the ability to shear-thin and recover. The hydrogel, both before and after shear-thinning, is capable of killing ..Identification Of Fat And Lean Phenotypes In Chickens Using Molecular MarkersThe present invention provides methods of screening chickens to determine those more likely to have a lean or fat phenotype. The invention also provides methods of screening chickens to identify a pol..DELIVERY OF HYDROGELS AS SPRAYSA method for delivering beta-sheet peptide hydrogels to a target surface by shear-thinning and spraying the peptide hydrogel on the surface is provided. The beta-sheet peptide hydrogels can be applied..FERTILITY ENHANCEMENT USING LIPID CARRIERS AND BIOACTIVE MOLECULESThe invention relates to a composition and method for enhancing fertilization. Fertilization enhancement is achieved by effectively delivering bioactive molecules with a lipid anchor (GPI-linked prote..Perlecan Fragments as Biomarkers of Bone Stromal LysisA method for the detection in a body fluid of perlecan polypeptide fragments that are biomarkers of tumor metastasis, and antibodies for detecting these fragments are described. An immunoassay kit for..MACROMOLECULAR DIFFUSION AND RELEASE FROM SELF-ASSEMBLED B-HAIRPIN PEPTIDE HYDROGELSA hydrogel for delayed release of an anionic macromolecule, wherein the hydrogel comprises the anionic macromolecule, 150 mM NaCl, and a peptide selected from the group consisting of SEQ ID NO:1 throu..METHODS AND COMPOSITIONS FOR THE DISPLAY OF POLYPEPTIDES ON THE PILI OF GRAM-POSITIVE BACTERIAProvided herein are methods and compositions for the display of polypeptides of interest on the tip of pili of Gram-positive bacteria. According to the present invention, the polypeptide of interest i..COATED QUANTUM DOTS AND METHODS OF MAKING AND USING THEREOFThe present disclosure provides embodiments of a new class of hydroxylated quantum dots. The quantum dots have a hydroxylated coat disposed thereon, and which serves to minimize non-specific cellular ..IMMUNOGENIC COMPOSITIONS AND METHODS OF USE THEREOFEmbodiments of the disclosure encompass compositions and methods for generating immune responses in an animal or human host Embodiments of the compositions encompass proteins derived from the surface ..Compositions and methods for generating an immune responseWe have developed DNA and viral vectors that can be used, alone or in combination, as a vaccine against one HIV clade, subtype, or recombinant form of HIV or against multiple HIV clades, subtypes, or ..MODULATION OF SODIUM CHANNELS BY NICOTINAMIDE ADENINE DINUCLEOTIDEThe present invention relates to the use of oxidized nicotinamide adenine dinucleotide (NAD+) or of its reduced form, NADH, as sodium channel modulators. The present invention also relates to the use ..METHODS OF MAKING MONOCLONAL ANTIBODIES USING FUSION- PEPTIDE EPITOPE ADOPTIVE TRANSFER (F-PEAT) TECHNOLOGYDisclosed are compositions and methods for related to monoclonal antibodies specific for single amino acid variation in an antigen.METHODS FOR DETERMINATION OF PROTEIN PHOSPHATASE ACTIVITY, AND USES IN PREDICTING THERAPEUTIC OUTCOMESOne aspect of the present disclosure encompasses methods for determining a protein kinase or phosphatase activity in a biological sample, comprising: contacting in a reaction mix a first test sample a..BHC80 - HISTONE COMPLEXES AND USES THEREOFProvided herein is the tertiary structure of domains of the BHC80 protein, including the PHD finger domain, such as when the BHC80 protein is complexed with an unmodified histone H3 tail in the presen..RE-ENGINEERED UV DAMAGE ENDONUCLEASE, COMPOSITIONS AND METHODSProvided are methods and compositions for reducing damage to skin by ultraviolet light and other agents that cause distortion to double stranded DNA and methods for reducing damage to other organs due..HETEROCYCLIC PEPTIDE KETOAMIDESA novel class of peptide a-ketoamides useful for selectively inhibiting calpains, selectively inhibiting cysteine proteases, and generally inhibiting all cysteine proteases, having the formula M-AA2-A..PH-dependent NMDA receptor antagonistsNMDA receptor blockers, including pH-sensitive NMDA receptor blockers, are provided as neurprotective drugs that are useful in stroke, traumatic brain injury, epilepsy, and other neurologic events tha..Imaging AgentsThis invention provides amino acid derivatives useful in detecting and evaluating brain and body tumors, including (1S,2S) anti-2-[18F]FACPC and (1R,2R) anti-2-[18F]FACPC.ALZHEIMER'S DISEASE IMAGING AGENTSThis invention provides compounds and methods of imaging amyloid deposits using radiolabeled compounds. This invention also provides a method of inhibiting the aggregation of amyloid proteins to form ..USE OF RANKL TO INDUCE DIFFERENTIATION OF MICROFOLD CELLS (M CELLS)The differentiation of microfold (M) cells is important in mucosal immunity. The differentiation of M cells is desirable, such as in situations in which a host response to an antigen is sub-optimal, o..PURINE NUCLEOSIDE MONOPHOSPHATE PRODRUGS FOR TREATMENT OF CANCER AND VIRAL INFECTIONSThe present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporo virus, HSV-I, HSV-2, Dengue ..9-AMINONOSCAPINE AND ITS USE IN TREATING CANCERS, INCLUDING DRUG- RESISTANT CANCERS9-aminonoscapine, prodrugs thereof, and pharmaceutically acceptable salts thereof, are disclosed. Pharmaceutical compositions including 9-aminonoscapine, and methods of preparation and use thereof are..AMINOQUINOLINE DERIVED HEAT SHOCK PROTEIN 90 INHIBITORS, METHODS OF PREPARING SAME, AND METHODS FOR THEIR USENovel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors and methods for making these classes are provided herein. These compounds are useful in treating and preventing cancer and..HEAT SHOCK PROTEIN 90 INHIBITORS, METHODS OF PREPARING SAME, AND METHODS FOR THEIR USENovel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors are disclosed. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases and condition..PROSTATE CANCER BIOMARKERS TO PREDICT RECURRENCE AND METASTATIC POTENTIALDescribed herein are methods for predicting the recurrence, progression, and metastatic potential of a prostate cancer in a subject. For example, the method comprises detecting in a sample from a subj..TRIARYLMETHANE ANALOGS AND THEIR USE IN TREATING CANCERSCompounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and compositions ca..INHIBITORS OF NOX ENZYMES AND METHODS OF USE THEREOFInhibitors of Nox enzymes, such as Noxl, Nox2, and Nox3, and methods of making and using such compounds are describe herein.Use of mTOR Inhibitors to Enhance T Cell Immune ResponsesIt is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T cell r..HUMAN ANTI-PD-1, PD-L1, AND PD-L2 ANTIBODIES AND USES THEREFORThe present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing, pro..DRUG RESISTANT IMMUNOTHERAPY FOR TREATMENT OF A CANCERThe present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer. The methods also relate to generating a drug-resistant cytotoxic immu..TUMOR IMAGING COMPOUNDSThe invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of alpha-aminoisobutyric acid (AIB) anal..ELICITING IMMUNE RESPONSES USING RECOMBINANT MVA VIRUSES EXPRESSING HIV ENV, GAG AND POL ANITGENSMethods for eliciting beneficial immune responses against HIV by administering to a subject a recombinant MVA virus expressing HIV env, gag, and pol antigens are described. The recombinant MVA is admi..GAMBOGIC AMINE, A SELECTIVE TRKA AGONIST WITH NEUROPROTECTIVE ACTIVITYSmall molecule agonists, partial agonists, and antagonists for the TrkA receptor are described. The compounds are gambogic amines, where the carboxylic acid group of gambogic acid (CO2H) has been repl..ASSESSING TUMOR RESPONSE TO THERAPYSystems, methods and computer program products identify first biologic data in a region of interest in a first image and calculate a first biologic volume histogram from the first biologic data. Secon..DWF4 Polynucleotides, Polypeptides and Uses ThereofThe present invention relates to novel, polynucleotides isolated from dwarf plants. The dwf4 polynucleotides that encode all, or a portion of, a DWF4 polypeptide, a cytochrome P450 enzyme that mediate..IMMOBILIZING AN ENTITY IN A DESIRED ORIENTATION ON A SUPPORT MATERIALThe present invention relates to the identification and selection of attachment molecules that attach/immobilize an entity having a detectable activity or property on a support in an orientation that ..RECOMBINANT BACTERIUM CAPABLE OF ELICITING AN IMMUNE RESPONSE AGAINST STREPTOCOCCUS PNEUMONIAEThe invention encompasses a recombinant bacterium capable of eliciting an immune response against Streptococcus pneumoniae, a vaccine comprising the bacterium, and methods of using the bacterium.SYNTHETIC ANTIBODIESThe present invention provides methods for synthetic antibodies, methods for making synthetic antibodies, methods for identifying ligands, and related methods and reagents.ARTIFICIAL LECTIN MIMICS AND USES THEREOFLectins are important class of sugar-binding proteins involved in a variety of biological phenomena. In some aspects, the present invention relates to the process of selection and application of high-..PROSTATE CANCER MARKERS AND USES THEREOFThe present invention provides methods for assessing the probability of a prostate tumor in a subject, or for monitoring efficacy of treatment for prostate cancer, involving detection of QSOX1 in pati..PANCREATIC CANCER MARKERS AND USES THEREOFThe present invention provides methods and reagents for assessing the probability of a subject having a pancreatic tumor, and for monitoring efficacy of treatments for pancreatic tumors.SYNTHETIC ANTIBODIESMethods for synthetic antibodies, methods for making synthetic antibodies, methods for identifying ligands, and related methods and reagents.SYNBODIES TO AKT1The present application provides synbodies against AKT1 differing in amino acid sequence, conjugation chemistry, linker/scaffold, or adjunct moiety. The synbodies are useful for diagnosis and treatmen..METHODS OF ASSESSING A RISK OF CANCER PROGRESSIONMethods and kits that use miRNA expression to predict the development of brain metastases in non-small cell lung cancer patients are disclosed.RECOMBINANT EDWARDSIELLA BACTERIUMThe present invention encompasses a recombinant Edwardsiella bacterium, and compositions and methods of use thereof.A DNA REPLICON SYSTEM FOR HIGH-LEVEL RAPID PRODUCTION OF VACCINES AND MONOCLONAL ANTIBODY THERAPEUTICS IN PLANTSPlant viral vectors have great potential in rapid production of proteins, but no simple Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including v..MOLECULAR FILMS FOR HYDROPHOBIC IMPLANT SURFACESCompositions are disclosed containing a solvated viscoelastic polymeric gel diluted into an ionically conductive aqueous solution which can be usefully applied to any surface that is hydrophobic to ac..METHODS FOR IDENTIFYING CANCER RISKProvided herein are tissue-specific differential methylated regions (T-DMRs) and cancer-related differential methylated regions (C-DMRs) and methods of use thereof. In one embodiment of the invention,..Methods of treating measles infectious disease in mammalsThe invention provides for a measles vaccine utilizing a human codon-optimized polynucleotide encoding a measles virus polypeptide, such as HA or F protein. Optionally, the vaccine is administered wit..Cardiac Stem CellsHuman cardiac stem cells can be isolated from endomyocardial biopsies. Such cells mediate cardiac regeneration and improve heart function in a mouse infarct model. The cells can be used for autologous..Integrated Analyses of Breast and Colorectal CancersGenome-wide analysis of copy number changes in breast and colorectal tumors used approaches that can reliably detect homozygous deletions and amplifications. The number of genes altered by major copy ..BIOLUMINESCENCE IMAGING-BASED SCREENING ASSAY AND INHIBITORS OF ABCG2A bioluminescence imaging-based high-throughput assay for inhibitors of ABCG2 is described. Compositions of inhibitors of ABCG2 and methods of using ABCG2 inhibitors are also described.DNA INTEGRITY ASSAY (DIA) FOR CANCER DIAGNOSTICS, USING CONFOCAL FLUORESCENCE SPECTROSCOPYThe present invention relates, e.g., to a method for determining the size distribution of DNA molecules in a sample comprising cell-free nucleic acid, comprising labeling the DNA with a fluorescent dy..METHODS FOR FREPARATION AND USE OF MARROW INFILTRATING LYMPHOCYTES (MILS)The invention provides compositions comprising activated marrow infiltrating lymphocytes, methods of generating populations of marrow infiltrating lymphcytes, uses of the marrow infiltrating lymphocyt..STAT3 ANTAGONISTS AND THEIR USES AS VACCINES AGAINST CANCERThe present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing Stat3 ..Methods for Identifying Cancer RiskThe present invention provides methods and kits for identifying an increased risk of developing cancer in a subject. The methods include analyzing a first biological sample, such as a blood sample, fr..Imidated biopolymer adhesive and hydrogelBiologically compatible polymers carry an imide and can be used as an adhesive, a hydrogel or both. A second biologically compatible polymer reactive with the imidated polymer can be used therewith to..Reagents and Methods for Engaging Unique Clonotypic Lymphocyte Receptorslatforms comprising at least one lymphocyte affecting molecule and at least one molecular complex that, when bound to an antigen, engages a unique clonotypic lymphocyte receptor can be used to induce ..Transgenic Frog Lines and Assays Employing ThemRhodopsin transgenes driven by rhodopsin promoters were produced, some attached to GFP coding sequences as a fusion construct. When the resulting transgenes were introduced into Xenopus laevis, the ph..MICROARRAYS OF BINARY NUCLEIC ACID PROBES FOR DETECTING NUCLEIC ACID ANALYTESDisclosed is a microarray of binary nucleic acid probes for the detection of one or a plurality of nucleic acid analytes in a complex sample in a single high throughput assay with extraordinary specif..Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue of boneMethods and apparatuses are provided for musculoskeletal tissue engineering. For example, a scaffold apparatus is provided which comprises microspheres of selected sizes and/or composition. The micros..A SPLIT DNA ENZYME FOR VISUAL SINGLE NUCLEOTIDE POLYMORPHISM TYPINGA probe that changes solution color in the presence of only one of the two DNA sequences, which differ by a single nucleotide, is reported. The probe consists of two oligodeoxyribonucleotides, which f..LINKED PEPTIDE FLUOROGENIC BIOSENSORSBiosensors, compositions comprising biosensors, methods of producing biosensors, and methods of using biosensors are disclosed. The biosensors comprise a fluorogen- activating peptide and a blocking p..MUTANTS OF THE P4 PROTEIN OF NONTYPABLE HAEMOPHILUS INFLUENZAE WITH REDUCED ENZYMATIC ACTIVITYA P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typable H. influenzae (NTHi) is useful as a..STEREOCHEMICALLY DEFINED DIPEPTIDE ESTERS OF ANTIVIRAL AGENTS FOR ENHANCED OCULAR TREATMENTStereochemically defined dipeptide esters of nucleoside-analogous antiviral agents including acyclovir and ganciclovir are provided. Certain of these stereochemically defined dipeptide esters are foun..PLANT ARTIFICIAL CHROMOSOME PLATFORMS VIA TELOMERE TRUNCATION.The invention provides engineered plant minichromosomes generated by telomere mediated truncation of native chromosomes. These minichromosomes are faithfully transmitted from one generation to the nex..ACYCLOVIR-PEPTIDE ANALOGSDipeptide and tripeptide ester derivatives of acyclovir and its analogs are disclosed which are useful to treat herpes virus infections. Also disclosed is a method for preparing a therapeutic agent fo..Drought Responsive Genes In Plants And Methods Of Their UseMicroarrays are employed to analyze soybean transcriptions under water stress conditions in both root and leaf tissues at vegetative stage. Novel drought responsive genes may be thus identified and ma..CAFFOLD FOR BONE AND TISSUE REPAIR IN MAMMALSA mammalian tissue scaffold and method for making a tissue scaffold including a rigid scaffold body of biocompatible glass fibers bonded together and in special alignment to define open channels withi..Method for detecting DNA methylation in cancer cellsThe present invention provides a detecting method of detecting malignant cells in a patient's specimen or a biological sample. Specifically, the inventive method includes the steps of extracting a gen..ASSAYS FOR DETECTING PREGNANCY- ASSOCIATED GLYCOPROTEINSDisclosed are methods and compositions for detecting pregnancy in an animal by means of assaying peptidase activity of one or more Pregnancy Associated Glycoproteins (PAGs). In certain aspects, method..Phage Display Selection of Anti Fungal PeptidesA method for the identification of peptides having an affinity for the surface of fungi is provided as is a method for the identification of peptides capable of affecting the development of a fungus. ..NOVEL INHIBITORS OF RETROVIRAL REVERSE TRANSCRIPTASEDisclosed are nucleic acid molecules, and methods of their use, which have a specific structure including a double helical domain and a G-quadruplex domain physically connected by a linker domain whic..Modulating levels of RNA-binding proteins for the treatment of breast cancerThe present invention relates to methods of using RNA-binding protein modulating agents to treat of cancer, particularly patients that are susceptible to or diagnosed with estrogen receptor-negative b..SELF-ASSEMBLING MULTICELLULAR BODIES AND METHODS OF PRODUCING A THREE-DIMENSIONAL BIOLOGICAL STRUCTURE USING THE SAMEStructures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse t..SCAFFOLDS WITH TRACE ELEMENT FOR TISSUE REGENERATION IN MAMMALSA scaffold for implantation into a mammal to facilitate vessel growth in repair, regeneration, and/or proliferation of bodily tissue, where the scaffold is based on a borate, silicate, or phosphate, g..CONTROLLING VESSEL GROWTH AND DIRECTIONALITY IN MAMMALS AND IMPLANTABLE MATERIALA method for directing vessel growth toward a blood-deficient site in a mammal comprising implanting into the mammal an assembly of at glass fibers to form a vascular bridge with a first end of the va..SCAFFOLD FOR TISSUE REGENERATION IN MAMMALSA three-dimensional scaffold with interconnected pores for repair of tissue comprising a scaffold body for structural support of the tissue scaffold, where the scaffold body comprises scaffold body co..METHOD TO DEVELOP HIGH OLEIC ACID SOYBEANS USING CONVENTIONAL SOYBEAN BREEDING TECHNIQUESDisclosed is a soybean plant with mutations in FAD2-1A and FAD2-1B. Moreover, disclosure is directed to seeds from said plants with altered ratios of monosaturated and polyunsaturated fats In particul..SOYBEAN TRANSCRIPTION FACTORS AND OTHER GENES AND METHODS OF THEIR USEGene expression is controlled at the transcriptional level by very diverse group of proteins called transcription factors (TFs). 5671 soybean (Glycine max) genes have been identified and disclosed as ..AUTISM-ASSOCIATED BIOMARKERS AND USES THEREOFBiomarkers for human autism are disclosed. Methods for treating, preventing, and diagnosing human autism and autism-related disorders are also disclosed.USES OF IMMUNOLOGICALLY MODIFIED SCAFFOLD FOR TISSUE PREVASCULARIZATION CELL TRANSPLANTATIONThis invention provides method of making and using of a porous 3 dimensional cyclic RGD peptide-modified alginate scaffold that can be loaded with different cell types and/or growth factors for implan..ENZYMATIC DEGRADATION OF A2E AND OTHER BISRETINOID COMPOUNDS OF RPE LIPOFUSCINThe present invention provides methods for reducing the amount of lipofuscin compounds present in a cell which comprises contacting the cell with an amount of an enzyme sufficient to directly or indir..RECOMBINANT HUMAN FOLLICLE STIMULATING HORMONE ANTAGONISTS AND METHODS OF USE THEREOFIn one embodiment the present invention is directed to a recombinant human follicle stimulating hormone (FSH) antagonist having reduced N-linked glycosylation. In other embodiments, the present invent..COMPOSITIONS OF HUMANIZED NOTCH FUSION PROTEINS AND METHODS OF TREATMENT.This invention provides a fusion protein comprising a signal peptide, an extracellular domain of human Notch receptor protein and an Fc portion of an antibody bound thereto. This invention also provid..SYSTEMS AND METHODS FOR INDUCING ELECTRIC FIELD PULSES IN A BODY ORGANSystems and methods for providing controllable pulse parameter magnetic stimulation are described. One aspect is directed to a magnetic stimulation system for inducing approximately rectangular electr..METHODS FOR INDUCING TRANSPLANTATION TOLERANCEA method is provided for preventing rejection by an immune system of a recipient subject of a tissue transplanted from a donor subject into the recipient subject without the need for long-term adminis..GAB2 AMPLIFICATION IN MELANOMAProvided herein are methods of detecting or inhibiting melanoma growth based on Gab2 protein expression. Gab2 protein was found to be either amplified and/or overexpressed in melanoma. Gab2 protein ex..HERPES VIRUS BACKBONE FOR VIRAL VACCINE AND VACCINE BASED THEREONA recombinant deoxyribonucleic acid comprising a human herpes simplex virus (HSV) deoxyribonucleic acid (DNA) having a heterologous DNA integrated therein wherein the heterologous DNA encodes a polype..OSTEOCHONDRAL IMPLANTS, ARTHROPLASTY METHODS, DEVICES, AND SYSTEMSImplants for resurfacing or repairing one or more articular cartilage bearing surfaces of a biological organism include an engineered tissue and a biocompatible porous substrate secured to the enginee..FIBROBLAST DERIVED STEM CELLSThe present invention provides methods and compositions relating to the production of stem cells, derived from dedifferentiated fibroblasts, and the use of such stem cells for treatment of a variety o..Massive parallel method for decoding DNA and RNAThis invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is i..SYSTEMS AND METHODS OF BLOOD-BASED THERAPIES HAVING A MICROFLUIDIC MEMBRANELESS EXCHANGE DEVICEThe present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent..ASSAY FOR DETERMINING HEALTH OF CD8+ T CELLSA method of determining if a subject's CD8+ T-cells functionally recognize an HLA-E/Hsp60sp target structure comppsmg a) contacting a sample of the subject's CD8+ T-cells with a HLA-E+ cell loaded wit..MICROBUBBLE DEVICES, METHODS AND SYSTEMSA hydrogel tissue engineering scaffold having microbubbles dispersed therein is disclosed. Also, a system for cell culturing including a controller and actuator to apply dynamic deformational loading ..LIGAND BINDING SITE OF RAGE AND USES THEREOFThe present method provides for an isolated peptide having an amino acid sequence corresponding to the amino acid sequence of a V-domain of a receptor for advanced glycation end product (RAGE). The pr..UNIVERSAL METHYLATION PROFILING METHODSThis invention provides methods of derivatizing a double-stranded DNA comprising contacting double-stranded DNA with a CpG methyltransf erase and an s-adenosylmethionine analog. This invention also pr..Delivery of Dna or Rna Via Gap Junctions from Host Cells to Target Cells and a Cell-Based Delivery System for Antisense or siRnaA method of delivering an oligonucleotide or a plasmid expressing an oligonucleotide into a target cell comprises introducing an oligonucleotide into a donor cell, particularly a stem cell, and contac..CANCER STEM CELLS, KITS, AND METHODSThe present invention provides a cancer stem cell that has, inter alia, the properties of asymmetrical cell division, tumor initiating capacity, and metastatic competence. This cancer stem cell popula..Transgenic mice over-expressing receptor for advanced glycation endproduct (RAGE) in brain and uses thereofThe present invention provides for a transgenic non-human animal whose cells contain a DNA sequence comprising: (a) a nerve tissue specific promoter; and (b) a DNA sequence which encodes a receptor fo..CONTROL OF SPORE GERMINATIONProvided is a method of stimulating germination of a spore of a Gram-positive bacterium. Also provided is a method of inhibiting germination of a spore of a Gram-positive bacterium. Additionally provi..COMPENSATING FOR ATRIOVENTRICULAR BLOCK USING A NUCLEIC ACID ENCODING A SODIUM CHANNEL OR GAP JUNCTION PROTEINA method of increasing the velocity of AV conduction in a mammal that may be in heart block or at risk of heart block by causing, in an AV node and/or His bundle having less than normal conduction spe..Method for assaying protein-protein interactionThe invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the use ..Methods for predicting pregnancy outcome in a subject by HCG assayThe present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invent..HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOFThe invention provides for a method for screening compounds that bind to and modulate a histone acetyltransferase protein. The invention further provides methods for treating neurodegenerative disorde..Nucleic acids for inhibiting hairless protein expression and methods of use thereofThe present invention provides DNAzymes and ribozymes that specifically leave Hairless Protein mRNA. The present invention also provides antisense oligonucleotides that specifically inhibit translatio..BIOREACTOR, DEVICES, SYSTEMS AND METHODSDisclosed are bioreactor devices, systems and methods. A bioreactor system can include one or more bioreactor modules that can be individually controllable and identifiable. A bioreactor module can be..SYSTEMS AND METHODS OF BLOOD-BASED THERAPIES HAVING A MICROFLUIDIC MEMBRANELESS EXCHANGE DEVICEThe present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent..MEDICAL IMPLANTS, PROSTHESES, PROSTHESIS PARTS, MEDICAL INSTRUMENTS, DEVICES AND AUXILIARY CONTRIVANCES MADE OF A HALOGENIDE-MODIFIED MAGNESIUM SUBSTANCEThe use of a magnesium substance, whose corrosiveness is altered as a result of modification with halogenides, enables medical implants, prostheses or prosthesis parts and medical instruments, devices..FLUOROGENIC SUBSTRATES FOR PROTEIN PHOSPHATASES AND ASSAYS INCORPORATING THE SUBSTRATESProvided is a class of fluorogenic protein phosphatase substrates. These fluorogenic substrates comprises a carbamate moiety having a carbamate functional group other than hydrogen bonded to the carba..LONG TERM POTENTIATION WITH CYCLIC-GLUR6 ANALOGSThis invention discloses CN2097-like compositions that facilitate the induction of long-term potentiation (LTP). In one embodiment the method comprises inducing long-term potentiation in a subject by ..INTEIN-BASED FLUORESCENT BIO-CIRCUIT FOR VITAMIN D DETECTIONThis invention is directed to an intein-based vitamin D fluorescent biosensor that accurately and rapidly measures la,25-hydroxyvitamin D3. Measurement at picomolar quantities is noted. Particular ref..DETECTION OF SHORT RNA SEQUENCESAn assay for detection of short sequences of RNA in a synthetic or clinically isolated sample is presented herein. Particular reference is made to detecting RNA based pathogens, such as H5 influenza.SIMULTANEOUS QUANTITATIVE MULTIPLE PRIMER DETECTION OF CLOSTRIDIUM DIFFICILEThis invention comprises a multiplex-capable oligonucleotide which is capable of hybridizing to at least one of the C. difficile tcdB, tcdC, or cdtB genes, wherein, wherein said primer consists of a s..METHODS OF DETECTING SOURCES OF MICROORGANISM CONTAMINATIONMethods of detecting a source of a microbial contamination in a suspect sample include detecting at least one member selected from the group consisting of a microbial geosmin synthase, a microbial 2-m..DEVICE AND NON-TOXIC COMPOSITIONS AND METHODS FOR PERMEABILIZATION OF DROSOPHILA EMBRYOSThe invention provides compositions and methods for permeabilizing insect embryos by removing the waxy layer of the shell using a solution containing a non-toxic cyclic terpene and a non-toxic surfact..PREDICTING HEMOSTATIC RISKFeatured are methods for assessing hemostatic risk including the risk for ACS. Such methods include acquiring blood/plasma composition based on a biological sample obtained from a subject, determining..METHODS OF DETECTION OF FACTOR XIA AND TISSUE FACTORThe invention provides compositions and methods for the detection of Factor XIa or Tissue Factor (TF) activity in a sample using an antibody based clotting time prolongation assay. The invention provi..Co-Administration of a Thrombolytic and an Anti-CD18 Antibody in StrokeA method for improving clinical outcome in focal ischemic stroke in a mammal by increasing cerebral blood flow and/or reducing infarct size is described which involves administering an effective amoun..METHODS AND PRODUCTS RELATING TO GSK3BETA REGULATIONThe invention relates to methods and compositions for regulation of GSK3[beta] activity. The invention provides phosphorylated GSK3[beta] polypeptides and antibodies that recognize such polypeptides. ..USE OF ANTIBODY SECRETING CELL ELISPOT TO ASSESS ANTIBODY RESPONSES FOLLOWING ANTIGEN EXPOSUREDisclosed are methods and kits for early detection of antigen exposure through the presence or absence of antigen-specific antibodies.TWO-DIMENSIONAL PHOTONIC BANDGAP STRUCTURES FOR ULTRAHIGH-SENSITIVITY BIOSENSINGThe present invention relates to two-dimensional photonic crystal arrays and their use in biological sensor chips, including those in the form of microfluidic devices. Methods of making the two-dimens..NUCLEIC ACID BINDING COMPOUNDS AND METHODS OF USEThe present invention relates to homo- and hetero-dimer compounds formed by a disulfide, sulfinyl thio, or olefin bond between two monomers. A method of making a homo- or hetero-dimer compound is also..USE OF NON-NUCLEOPHILIC ADDITIVES FOR REDUCTION OF SURFACE MORPHOLOGICAL ANOMALIES IN PROBE ARRAYSThe present invention relates to a formulations and methods for coupling a reactant (or probe precursor) to a functionalized surface for purposes of forming an arrayed sensor. This method includes the..NURR1 INTERACTING PROTEIN (NUIP)Provided herein are methods of promoting the activity of Nurr1 in a cell comprising contacting the cell with NuIP or an analog or fragment thereof. Also provided are methods of treating or preventing ..Non-androgen dependent roles for androgen receptor in liver cancerDisclosed are compositions and methods for modulating AR activity, such as non-androgen dependent AR activity. Also disclosed are compositions and methods for diagnosing beast cancer and for inhibitin..Automated placental measurementA method for analyzing the placenta and histology slides of placental tissue comprising: selecting a placental sample to be analyzed; obtaining a digital image of the placental sample; and performing ..Gene Differentially Expressed in Breast and Bladder Cancer and Encoded PolypeptidesThe present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to methods of treating or preventing a disorde..OPTICAL DETECTION AND MONITORING OF CANCER USING A PROTEIN BIOMARKERA method of detecting and staging pre-invasive and invasive cervical cancer is disclosed. A cervical tissue is illuminated in vivo with an incident light. Spectral emissions from the cervical tissue a..Nogo-Receptors and Methods of UseDisclosed are compositions relating to the Nogo receptor (NgR) family as well as fragments, chimeras, and variants thereof. The invention provides polypeptides, nucleic acids, vectors, expression syst..METHODS AND COMPOSITIONS RELATED TO SYNERGISTIC RESPONSES TO ONCOGENIC MUTATIONSDisclosed are compositions and methods related to new targets for cancer treatment.Continuous flow chamber device for separation, concentration, and/or purification of cellsThe present invention relates to methods and apparatuses for cell separation. In particular, the invention relates to separation of a particular cell type from a mixture of different cell types based ..Altered ospa of borrelia burgdorferiProvided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptid..CHROMOSOMAL REARRANGEMENTMaterials and methods for the detection and mapping of chromosomal rearrangements in a biological sample are provided. In general, the assay involves the synthesis of detectably labeled nucleic acid e..Helper Virus-Free Herpesvirus Amplicon Particles and Uses ThereofThe invention features new helper virus-free methods for making herpesvirus amplicon particles that can be used in immunotherapies, including those for treating any number of infectious diseases and c..RECOMBINANT FACTOR VIII HAVING INCREASED STABILITY.The present invention relates to a recombinant factor VIII that includes one or more mutations that result in enhanced stability of both factor VIII and factor VIIIa. Methods of making and using the r..DC-STAMP ANTIBODIESProvided herein are antibodies that specifically bind an epitope of DC-STAMP. Specifically, provided herein are monoclonal antibodies that bind an epitope of DC-STAMP, wherein the epitope comprises th..ULTRASOUND TECHNOLOGY TO CONTROL THE SPATIAL ORGANIZATION OF CELLS AND PROTEINS IN ENGINEERED TISSUESThe present invention is directed to methods of inducing spatial organization of cells an in vitro culture system using ultrasound technology. The invention is further directed to methods of inducing ..SPATIALLY INHOMOGENOUSLY FUNCTIONALIZED POROUS MEDIA AND METHOD FOR USE IN SELECTIVE REMOVAL OF CONTAMINANTSCompositions and methods for separating double-stranded nucleic acids out of a mixture comprising single-stranded nucleic acids and/or dNTPs and/or enzymes. The method uses spatially inhomogenously fu..COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALINGDisclosed are compositions and methods for treating diseases associated with G protein [beta][gamma] subunit activity.ANIMAL MODEL FOR OSTEOARTHRITIS AND INTERVERTEBRAL DISC DISEASEProvided herein is a transgenic animal whose genome comprises a first nucleic acid sequence encoding a fusion polypeptide, wherein the fusion polypeptide comprises a Cre recombinase and a mutated liga..MLK INHIBITORS AND METHODS OF USEProvided are compounds having an inhibitory effect on Mixed Lineage Kinases. Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of ..PREVENTING AND TREATING SEPSISProvided are polypeptides comprising a variant activated protein C comprising one or more amino acid substitutions selected from the group consisting of K146R, D172N, C212R, K146G, R147G, R177G and co..SOLUBLE LOW-DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN BINDS DIRECTLY TO ALZHEIMER'S AMYLOID-BETA PEPTIDEA soluble derivative of low-density lipoprotein receptor related protein-1 (sLRP-1) binds directly to Alzheimer's amyloid-[beta] peptide (A[beta]). This binding may be used to detect A[beta] or to sep..ENHANCING THE THERAPEUTIC EFFECT OF ACUPUNCTURE WITH ADENOSINEThe present invention relates to a method of improving the therapeutic effect of acupuncture in a subject. The method involves administering adenosine, an adenosine mimetric, an adenosine modulator, a..PRODUCTION OF HUMAN PAPILLOMAVIRUS CAPSID PROTEIN AND VIRUS-LIKE PARTICLESThe present invention is directed to a method of expressing the papillomavirus capsid protein coding sequence in a cell using an expression system under conditions facilitating expression of the prote..PSA AND KLK2 AS THERAPEUTIC TARGETS AND MOLECULES INHIBITING PSA AND KLK2Disclosed herein are compositions and methods relating to prostate-specific antigen (PSA), KLK2 and androgen receptor. Further provided are methods and compositions for inhibiting PSA and/or KLK2 acti..Thioredoxin Interacting Protein (TXNIP) As Regulator Of Vascular FunctionThe present invention relates to screening assays for the identification of agents that can modify the interaction of thioredoxin interacting protein (TXNEP) on thioredoxin (TRX)5 preferably by inhibi..FIBROBLAST GROWTH FACTOR (FGF) ANALOGS AND USES THEREOFThe invention relates to novel peptide comprising FGF-P and methods of use thereof.TREATING MYELIN DISEASES WITH OPTIMIZED CELL PREPARATIONSThe disclosure relates to oligodendrocyte-biased glial progenitor cells and methods of making, isolating, and using such cells.TUMOR SUPPRESSION THROUGH PLEXIN C1Disclosed are compositions and methods relating to Plexin C1 and diagnosing, treating, and evaluating treatment for cancer.METHODS OF TREATING B-CELL CANCERSThe present invention is directed to methods of causing malignant B-cells and treating malignant B-cells. These methods involve the use of an inhibitor of PKK activity, whether active directly against..USE OF PROTEIN TYROSINE INHIBITOR SUCH AS GENISTEIN IN TREATING DIABETIC RETINOPATHY OR OCULAR INFLAMMATIONPROBLEM TO BE SOLVED: To provide a method for prophylactically and therapeutically treating diabetic retinopathy and a method for prophylactically and therapeutically treating ocular inflammation. ; S..ABLATION BASED LASER MACHINING OF BIOMOLECULE PATTERNS ON SUBSTRATESA method for patterning a one or more biomolecules on a substrate that includes coating the substrate with a coating of the one or more biomolecules, applying a laser to the coating, and ablating a po..COMPOSITIONS AND METHODS FOR EX VIVO HEPATIC NUCLEIC ACID DELIVERYThe invention provides compositions and methods for delivery of nucleic acids to the liver ex vivo. The method includes slow, low pressure infusion of the nucleic acid into the liver to efficiently tr..A NOVEL IN VITRO HIV-1 LATENCY MODEL FOR SCREENING REACTIVATION AGENTS OF HIV-1In one aspect, the present invention provides an isolated Bcl-2-transduced cell that comprises, integrated into the genome of the cell, a transcription-competent immunodeficiency virus or a transcript..DETECTING AND SORTING METHYLATED DNA USING A SYNTHETIC NANOPOREProvided are methods for detecting, characterizing or separating DNA based on methylation. Heterogeneous DNA populations are separated based on DNA methylation by providing a membrane having a nanopor..ANNEXINA2 AS IMMUNOLOGICAL TARGETAnnexinA2 (ANXA2), a member of the Annexin family of calcium-dependent, phospholipid binding proteins, is one of a panel of identified antigens recognized by the post-vaccination sera of patients who ..CELLS FOR INCREASED PROTEIN EXPRESSION COMPRISING ONE OR MORE RELEASE FACTORS AND METHODS OF USEThe invention provides recombinant cells or recombinant restrictive cells for overexpressing one or more proteins comprising one or more release factors. The invention also provides methods for produc..Hypoxia Induced Mitogenic FactorWe found that FIZZ1/RELM[alpha] is inducible by hypoxia in lung. The hypoxia-upregulated expression of FIZZ1/RELM[alpha] was located in the pulmonary vasculature, bronchial epithelial cells, and type ..Leucine-rich repeat kinase (LRRK2) drosophila model for parkinson's disease: wildtype1 (WT1) and G2019S mutant fliesMutations in the leucine-rich repeat kinase (LRRK2) gene cause late-onset autosomal dominant Parkinson's disease (PD) with pleiomorphic pathology. Previously, we and others found that expression of mu..PARSTATIN PEPTIDES AND USES THEREOFThe invention provides parstatin peptides, particularly a mammalian parstatin peptide including amino acids 1-26 of full length mammalian parstatin, preferably a human parstatin. The invention provide..METHODS OF TREATING BRAIN TUMORS WITH ANTIBODIESThe application is directed toward a method of treating a brain tumor in a patient comprising systemically administering a monoclonal antibody.MULTICOMPONENT DEGRADABLE CATIONIC POLYMERSDegradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions,..SINGLE MOLECULE SPECTROSCOPY FOR ANALYSIS OF CELL-FREE NUCLEIC ACID BIOMARKERSThe present invention relates, e.g., to a method for detecting a nucleic acid molecule of interest in a sample comprising cell-free nucleic acids, comprising fluorescently labeling the nucleic acid mo..Methylated CpG Island Amplification (MCA)The present invention provides a method for identifying a methylated CpG containing nucleic acid by contacting a nucleic acid with a methylation sensitive restriction endonuclease that cleaves unmethy..CYTOKINE RECEPTOR CHAINPROBLEM TO BE SOLVED: To provide a receptor fragment having an affinity to IL-13, a method for producing the same, and the treating use of the same. ; SOLUTION: A polynucleotide having a specific sequ..CANCER STEM CELL EXPRESSION PATTERNS AND COMPOUNDS TO TARGET CANCER STEM CELLSDescribed herein are therapeutic targets expressed in cancer stem cells and methods for treating and diagnosing cancer by targeting such cells with antibodies, compounds, nucleic acid, or other therap..SOCS-1 GENE METHYLATION IN CANCERMethods are provided for identifying a cell exhibiting unregulated growth associated with methylation-silenced transcription of a suppressor of cytokine signaling (SOCS)/cytokine-inducible SH2 protein..Antibodies that Specifically Bind Hedgehog-Derived PolypeptidesThe present invention provides two novel polypeptides, referred to as the "N" and "C" fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific clea..CO-POLYMER STABILIZERS FOR HYDROFLUOROALKANE DISPERSIONSThe use of biodegradable and biocompatible lactide-based nonionic amphiphiles to stabilize a model drug (salbutamol base) dispersion in hydrofluoroalkane (HFA) propellant is disclosed. The results hav..ACTIVATED T CELLSProvided are compositions comprising activated T cells and activated T cells armed with bispecific antibodies directed at cancer antigens which are poor responders to alloantigen, and methods of using..METHOD AND COMPOSITION FOR A PROTEIN TRANSDUCTION TECHNOLOGY AND ITS APPLICATIONSA protein transduction method for efficiently delivery of exogenous proteins into mammalian cells is invented, which has the capability of targeting different cellular compartments and protection from..2,2-Bis-(hydroxymethyl)cyclopropylidenemethyl-Purines and -Pyrimidines As Antiviral AgentsCompounds which are active against viruses have the following formulas: wherein B is a purine or pyrimidine heterocyclic ring or base. In a preferred embodiment, the purine include 6-aminopurine (aden..GENUS-WIDE CHLAMYDIAL PEPTIDE VACCINE ANTIGENSPeptides generated from a random library that are bound by a monoclonal antibody to Chlamydial glycolipid exoantigen (GLXA) and thus mimic this antigen are disclosed. Peptides that correspond to antig..BIOMARKERS FOR DIAGNOSTIC AND THERAPEUTIC METHODSErythrocyte ATP-release modulators and composition and methods for their use as biomarkers of glucose processing or vascular disorders, as well as methods for screening to identify to modulators; meth..Galectin-3 cleavage as a marker for matrix metalloproteinase activity in cancerProvided are differential antibodies recognizing the cleaved and non-cleaved forms of matrix metalloproteinases (MMPs), and methods of using the antibodies as surrogate diagnostic markers for the pres..THERAPEUTIC AMIDESThe invention provides compounds of the formula: wherein X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical comp..MODIFIED EGFR ECTODOMAINA protein that attenuates EGFR and/or EGFR family members comprises a modified EGFR ectodomain. The protein inhibits signaling via the EGFR and/or EGFR family members. The protein includes a portion o..CYCLIC-GLUR6 ANALOGS, METHODS OF TREATMENT AND USEA composition which is reversible inhibitor of at least one neuron-specific PDZ domain comprising wherein structure (5), R is a molecular transporter with or without a linker amino acid; R1 is at leas..Hybrid 2-aminoterailin and aryl-substituted piperazine compounds and their use in altering CNS activityHybrid compounds containing an aminotetralin moiety or a heterocyclic and/or open chain analog thereof linked through an alkylene group to an aryl ring system-substituted piperidiene moiety exhibit hi..POLYAMINES USEFUL AS ANTI-PARASITIC AND ANTI-CANCER THERAPEUTICS AND AS LYSINE-SPECIFIC DEMETHYLASE INHIBITORSPolyamine, polyamine/guanidino, and polyamine/biguanide compounds are disclosed. The compounds are useful as anti-cancer and anti-parasitic treatments. The compounds are also useful as inhibitors of t..METHOD FOR IDENTIFYING A SUBPOPULATION OF MAMMALIAN CELLS WITH DISTINCTIVE RIBOSOME TRANSLATION PROFILESThe present invention generally relates to subpopulations of mammalian cells with distinctive ribosome translational profiles, i.e. translational activities. The present invention further relates to m..Non-Natural Peptides as Models for the Development of AntibioticsDescribed herein are methods of screening one of the RNA hairpins in the small ribosomal subunit of bacteria to identify peptides that bind to it. The RNA hairpin target may be the 970 loop (aka helix..ENGINEERING POROUS PARTICLES OF WATER SOLUBLE THERAPEUTICS FOR PRESSURIZED METERED-DOSE INHALER FORMULATIONSThe subject matter disclosed herein relates to methods for engineering porous particles of water soluble therapeutics with enhanced physical stability and aerosol characteristics in hydrofluoroalkane ..Homogeneous distribution of cellular suspension in porous carrier material for tissue engineering under using molded body with chamber having opening, comprises introducing the carrier material providThe process for homogeneous distribution of a cellular suspension in a porous carrier material (3) for tissue engineering under using a molded body (1) with a chamber (2) having an opening for receivi..PROCESS FOR THE PREPARATION OF CYCLODEXTRINS COMPOSED OF MORE THAN EIGHT GLUCOSE UNITSA process for the preparation of large-ring cyclodextrins (LR-CD) with a degree of polymerisation (DP) of 9 - 21 from starch is described. LR-CD are obtained in a biocatalytic process in high yields b..PROMOTION OF PEROXISOMAL CATALASE FUNCTION IN CELLSThe molecular mechanisms of peroxisome biogenesis have begun to emerge; in contrast, relatively little is known about how the organelle functions as cells age. The present inventors characterized age-..POLYCLONAL BISPECIFIC ANTIBODY COMPOSITIONS AND METHOD OF USEThe invention relates to compositions and methods for treating a host infected with a pathogen. The composition comprising a population of polyclonal bispecific binding molecules that can target and e..COMPOSITIONS AND METHODS FOR DETECTING AND MODULATING CELL DEATH BY A TRANSLATION REGULATED GENE EXPRESSION SYSTEMThe technology relates to a nucleic acid expression cassette comprising a TR element encoding an mRNA molecule that is translated in stressed and/or dying cells, and a nucleotide sequence operably lin..ANTI-CANCER THERAPEUTIC STRATEGY TO OVERCOME CANCER RESISTANCE AND TO ENABLE TAILORING TREATMENT TO PATIENTSA gene construct comprising a programmed-cell-death executioner gene having a nuclear localization signal, a deleted signal peptide, an actin-resistant binding site, a promoter, and an activator. A me..THERAPEUTIC COMPOSITIONS AND METHODS FOR DELIVERY OF ACTIVE AGENTS CLEAVABLY LINKED TO NANOPARTICLESVarious embodiments of the present invention pertain to therapeutic compositions that comprise: (1) an active agent (e.g., paclitaxel); and (2) a nanoparticle (e.g., gold nanoparticle). In such embodi..METHODS OF FABRICATING ENHANCED TISSUE-ENGINEERED CARTILAGECompositions and methods for fabricating a tissue-engineered cartilage construct comprising: providing a cell sample comprising a plurality of chondrocytes; culturing the cell sample to produce a tiss..SYSTEMS AND METHODS FOR MAGNETIC GUIDANCE AND PATTERNING OF CELLS AND MATERIALSSystems and methods generally useful in medicine, cellular biology, nanotechnology, and cell culturing are discussed. In particular, at least in some embodiments, systems and methods for magnetic guid..SYSTEMS AND METHODS FOR PRODUCING PLASTID PROTEINSMethods and systems that include a method comprising: providing a system comprising one or more plastid proteins comprising a signal sequence and one or more chloroplast processing enzymes; and allowi..SPERMICIDAL AND MICROBICIDAL COMPOSITIONSProvided herein are new spermicidal compositions that include one or more fluorous surfactants, e.g., non-ionic fluorous surfactants, anionic fluorous surfactants, cationic fluorous surfactants, and c..BISPHOSPHONATE-PROSTATIC ACID PHOSPHATASE INHIBITOR CONJUGATES TO TREAT PROSTATE CANCER BONE METASTASISThe present invention concerns conjugate compounds comprising a bisphosphonate covalently bonded to a prostatic acid phosphatase inhibitor and compositions comprising such conjugates. Methods for trea..SERUM MARKERS ASSOCIATED WITH EARLY AND OTHER STAGES OF BREAST CANCERMethods for identifying disease-specific markers, in particular breast cancer markers, by electrophoretically separating serum albumin complexes in a biological sample on a membrane are provided. Elec..COMPOSITE BONE GRAFTS, PARTICULATE BONE-CALCIUM SULFATE CONSTRUCTS, AND METHODS OF TREATING JOINT INJURIESA solid implantable bone construct (12) shaped like a cylinder, a cone, or a frustum, for anchoring ligament implants. The bone construct (12) can include a bone component and a biocompatible solid co..ANTIBACTERIAL PEPTIDES ACTIVE IN SYSTEMIC INFECTIONSAntimicrobial peptides of the formula are provided: X1-X2-PrO- X3- X4-PrO- Arg- Pro-Tyr-Leu-Pro- X5-Pro-Arg-Pro-Pro-Arg-Pro-Y, wherein X1 is a natural or non-natural amino acid having a free amino gro..MANIPULATING SP1 ACTIVITY TO IMPROVE THERAPEUTIC CLONINGThe observed over-expression of Sp1 target genes has inspired inventors to formulate a specific strategy for correcting many gene expression defects, and thus improve clone development. The invention ..AN ASSAY FOR SCREENING/RANKING ANTIOXIDANTS BASED ON THEIR EFFECTS ON MEMBRANE STEROL LATERAL ORGANIZATIONA method of screening an antioxidant for potency and/or toxicity in vitro, the method includes contacting the antioxidant with a model system comprising a sterol superlattice formation capable of gene..USE OF NIBP POLYPEPTIDESMethods for regulating NF-?B activation in cells comprising introducing into the cell a vector comprising a nucleic acid sequence encoding a NIK and IKK2 Binding Protein (NIBP) polypeptide, wherein th..TRIGGERABLY DISSOLVABLE HOLLOW FIBERS FOR CONTROLLED DELIVERYProvided are tubular structures of a biocompatible, triggerably-dissolvable material such as cellulose or a copolymer having an LCST below physiological temperatures. The structures may be embedded wi..BIOSENSORS AND RELATED METHODSProvided herein are biosensors that comprise a biological signal source linked to a substrate by a peptide nucleic acid spacer and methods of use of the biosensor. In one embodiment, the biosensor is ..MICRORNAS IN IDIOPATHIC PULMONARY FIBROSISThe present invention relates to the discovery that certain microRNAs are differentially expressed in Idiopathic Pulmonary Fibrosis. The present invention provides for diagnostic methods, therapeutic ..NITRO FATTY ACIDS AS REGIOMERS AND RELATED MIMETICSMimetics of nitro linoleic acid are potent agonists of PPAR-?, a receptor that regulates adipocyte differentiation, glucose homeostasis and insulin sensitivity. Thus, 10-LNO2 and 12-LN-NO2 are potent,..POLYPEPTIDES AND USES THEREOFThe invention provides a polypeptide having a sequence comprising from 10 to 24 consecutive amino acids from residues 215-233 of the sequence of human cyclin B1 protein or homolog thereof, as well as ..CYTOTOXIC T CELL DEFINED EGFR PEPTIDE AND AN OPTIMIZED DERIVATIVE PEPTIDEThe invention provides a polypeptide having a sequence of amino acids consisting of IXDFGLAKL (SEQ ID NO: 1), as well as a nucleic acid encoding the polypeptide, vector comprising the nucleic acid, ce..NOVEL BIOSENSORS FOR LIVE CELL IMAGING OF INTRACELLULAR PROTEINSThis invention is related to the field of imaging intracellular protein processing. Fluorescent probes capable of changing color over time are used to identify and track the synthesis, trafficking, an..TARGETING AN HIV-1 NEF-HOST CELL KINASE COMPLEXDrug candidates for inhibition of HIV-I replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory activity w..CANCER STEM CELL IMMORTALIZATIONThe present invention relates to the preparation and use of immortalized cancer stem cells. The immortalized cancer stem cells of the invention may be used in assays to identify anti-cancer compounds ..EARLY PROSTATE CANCER ANTIGEN-2: A NOVEL SERUM SPECIFIC MARKER FOR PROSTATE CANCER DETECTIONEarly Prostate Cancer Antigen-2 (EPCA-2) is a prostate cancer biomarker, newly identified via proteomics-based examination of alterations in nuclear structure. EPCA-2 shows a higher overall specificit..SUBSTANCE P AND ANALOGS THEREOF AS A CANCER IMMUNOGENIC COMPOSITION ADJUVANTDisclosed herein are methods and compositions effective for treating, preventing, and ameliorating cancer that utilize Substance P or Substance P analogs and antigens. Also disclosed are methods for v..METHODS OF LABELING BIOLOGICAL SAMPLESMethods are provided for labeling specific oxidized proteins. Methods also are provided for determining the oxidation state of a cell. Such methods are useful as diagnostic, therapeutic and screening ..ADIPOSE-DERIVED STEM CELLS AND LATTICESThe present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and ..CELL LINEThe invention provides a cell line complementing HSV ICP4, ICP27, and UL55 genes.THERAPEUTIC AND DIAGNOSTIC CLONED MHC-UNRESTRICTED RECEPTOR SPECIFIC FOR THE MUC1 TUMOR ASSOCIATED ANTIGENThe invention provides an isolated nucleic acid encoding a receptor, other than an immunoglobulin, wherein the receptor binds to a MUC1 tumor antigen independently of an major histocompatibility compl..ARTIFICIAL CELL CONSTRUCTS FOR INDUCING IMMUNOLOGICAL TOLERANCEThe present invention contemplates induction of immunological tolerance thereby providing permanent allograft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive agen..HUMAN LEUKOCYTE ANTIGEN ALLELES ASSOCIATED WITH ADVANCED LUNG DISEASESThe present invention relates to methods and compositions that may be used to predict the risk of an individual, for example a smoker, for developing chronic obstructive pulmonary disease ("COPD"), em..THERMORESPONSIVE, BIODEGRADABLE, ELASTOMERIC MATERIAL AND USES THEREFORProvided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers are non-toxic and typically have an LCST below 37 DEG C. Compositions comprising the copolymers c..SMALL MOLECULE INHIBITORS OF DUSP6 AND USES THEREFORCompounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The compoun..LINKED MYC-MAX SMALL MOLECULE INHIBITORSProvided herein are compounds and compositions for interfering with the association of Myc and Max. These compounds and compositions are useful in methods for inhibiting growth or proliferation of a c..BIOLOGIC SCAFFOLD FOR PREVENTION OF PULMONARY FIBROSISProvided herein are methods of preventing, lessening or treating pulmonary fibrosis in a subject. The methods comprise delivering an amount of a powdered extracellular matrix (ECM)-derived material to..MUSCLE DERIVED CELLS (MDCS) FOR PROMOTING AND ENHANCING NERVE REPAIR AND REGENERATIONThe present invention describes methods involving the use of muscle derived cells (MDCs), preferably obtained from skeletal muscle, to support the innervation and repair of damaged tissues and organs,..FSTL-1 AS A BIOMAKER OF INFLAMMATIONThe invention provides methods and kits for diagnosing severity of particular types of inflammatory diseases, such as rheumatic diseases, by assessing protein levels of follistatin-like protein 1 (FST..Identification of markers in esophageal cancerMethods for identifying expression of markers indicative of the presence of esophageal, a squamous cell cancer, a squamous cell cancer of the head and neck, colon cancer and melanoma are provided. Als..BONE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS IN BIOCOMPATIBLE MATRIX, AND TREATMENTS THEREOFThe present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e...TARGETED NITROXIDE AGENTSProvided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a..Biomarkers For Prognosis of Pulmonary DiseasesThe present invention relates to biomarkers that may be used to evaluate the prognoses of patients suffering from pulmonary diseases and assist in the determination of appropriate therapeutic regimens..BIOERODIBLE WRAPS AND USES THEREFORA tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun..Porous Biomolecule-Containing Metal-Organic FrameworksThe present invention relates to compositions including porous biomolecule-containing metal-organic frameworks and methods for their preparation. The porous biomolecule-containing metal-organic framew..OXYGEN DEPLETION DEVICES AND METHODS FOR REMOVING OXYGEN FROM RED BLOOD CELLSAn oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within ..ENGINEERED MICROPARTICLES FOR MACROMOLECULE DELIVERYA method for making a modified release composition, comprising: selecting a desired active agent and polymer matrix for formulating into a modified release composition; assessing degradation effect on..METHODS FOR EXPANDING REGULATORY T-CELLSThe present invention relates a method of expanding and enriching a regulatory T-cell population. Specifically, the invention relates to methods of expanding regulatory T-cells by contacting leukocyte..CO-CRYSTAL OF ANTIBODY 11F8FAB FRAGMENT AND EGFR EXTRACELLULAR DOMAIN AND USES THEREOFThe present invention relates to co-crystals of antibody 11F8 Fab fragments and the complete extracellular domain of EGFR or isolated domain III of EGFR, and structural coordinates obtained from such ..USE OF AN ANTIBODY AND A RARE-EARTH BASED CRYSTAL[00152] The present invention provides compositions and methods for the detection of red blood cells antigens. The methods and compositions are based on antibodies, serving as primary antibodies or se..COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF HIF-1 ALPHARNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is als..THE USE OF IL-27-P28 TO ANTAGONIZE IL-6 MEDIATED SIGNALINGProvided are methods increasing, or, alternatively, decreasing IL-6 and/or gpl30-mediated signaling in mammalian subjects using p28. Methods of preventing and/or treating autoimmune disorders, cancer,..BIOMATERIALS FOR TISSUE REPLACEMENTThis invention relates to biomaterial compositions, methods and kits for producing hydrogels with tunable physico-chemical properties. Specifically, the invention relates to producing cellulosic hydro..HYDROLYTICALLY DEGRADABLE POLYSACCHARIDE HYDROGELSProvided are polysaccharide compositions capable of controllable hydrolytic degradation and suitable for controlled release of therapeutic agents. Also provided are methods for synthesizing such compo..COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ANGIOGENESISRNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these gene..COMPOSITIONS COMPRISING HMW-MAA AND FRAGMENTS THEREOF, AND METHODS OF USE THEREOFThis invention provides recombinant polypeptides comprising listeriolysin fused to an antigen such as a fragment of a High Molecular Weight Melanoma- Associated Antigen (HMW- MAA), recombinant Listeri..COMPOSITIONS AND METHODS FOR INHIBITING AN ONCOGENIC PROTEIN TO ENHANCE IMMUNOGENICITYThe present invention includes compositions and methods for inhibiting an oncogenic protein or its down-stream effector protein to suppress expression of a cell-surface protein involved in inhibiting ..LIGAND-SPECIFIC INHIBITION OF ATTACHMENT OF IMMUNE CELLS TO IMPLANTABLE BIOMATERIALSMethods for protecting biomater?als comprise attaching CD47 or Ig domain thereof to the surface of the biomaterial, thereby inhibiting or reducing immune cell attachment and/or immune cell-mediated da..TRANSCRIPTOME TRANSFER PRODUCES CELLULAR PHENOTYPE CONVERSIONThe present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a phenot..MODULATORS OF TDP-43 MEDIATED TOXICITYCompositions and methods are disclosed for identifying agents useful for the treatment of proteinopathies.MICRO-RNA BIOMARKER IN CANCERThis invention provides compositions and methods for predicting and improving a chemotherapy response to treat an ovarian cancer. In one embodiment, the invention provides compositions and methods for..REGULATORS OF THE INTERFERON-ALPHA RECEPTOR 1 (IFNAR1) CHAIN OF THE INTERFERON RECEPTORThe present invention includes compositions and methods for modulating a regulator of IFNARl. The invention includes inhibitors and activators of PERK, PTPlB, and/or PKD2 wherein inhibition, or activa..SIMIAN ADENOVIRUS 41 AND USES THEREOFNovel simian adenovirus 41 and two isolates thereof are described. Various uses of these isolates, including construction of a recombinant vector which comprises simian adenovirus 41 sequences and a h..SIRNA COMPOSITIONS FOR INHIBITION OF HIF-1 ALPHARNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is als..Heterologous Protein Production Using The Twin Arginine Translocation PathwayProvided are means for evaluating and identifying putative substrates of the twin arginine translocation (Tat) secretory pathway in Streptomyces and other bacterial species. Also provided, therefore, ..SIMIAN SUBFAMILY B ADENOVIRUSES SADV-28,27,-29,-32,-33, AND -35 AND USES THEREOF.A recombinant vector comprises simian adenovirus 28, simian adenovirus 27, simian adenovirus 32, simian adenovirus 33, and/or simian adenovirus 35 sequences and a heterologous gene under the control o..SIMIAN SUBFAMILY E ADENOVIRUSES SADV-39, -25.2, -26, -30, -37, AND -38 AND USES THEREOF.A recombinant vector comprises simian adenovirus SAdV-39, -25.2, -26, - 30, -37, and -38 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian..Activation and Expansion of T-Cells Using An Engineered Multivalent Signaling Platform as a Research ToolProvided are a system and methods for selectively inducing expansion of a population of T cells in the absence of exogenous growth factors, such as lymphokines, and accessory cells for research purpos..CONTROLLED ADENO-ASSOCIATED VIRUS (AAV) DIVERSIFICATION AND LIBRARIES PREPARED THEREFROMA method for the directed production of a combinatorial library of an altered protein coding sequence is described. The method involves predetermining at least two different nucleotide sequence fragme..METHODS AND COMPOSITIONS FOR IN-VIVO ENZYME CAPTUREThe invention includes compositions, methods and kits for the in vivo identification of an enzyme that binds to a substrate. The invention comprises, in part, a photoreactive moiety to aid in identifi..AMINOTHIENOPYRIDAZINE INHIBITORS OF TAU ASSEMBLYThe present invention is directed to methods of inhibiting a tauopathy in a patient by administration of a compound of formula (I): Novel aminothienopyridazine compounds are also described.NOVEL MOLECULAR BEACONSThe invention provides novel compositions and methods for the detection of a target molecule. Specifically, the invention provides a bimolecular beacon composition comprising two nucleic acid molecule..ARTIFICIAL MENISCAL IMPLANTSProvided are three dimensional shaped porous, fibrous polymer scaffolds capable of mimicking the functional properties of native tissue of a knee meniscus, and methods for manufacturing and using said..SINGLE DIASTEREOMERS OF 4-FLUOROGLUTAMINE AND METHODS FO THEIR PREPARATION AND USEThe present invention is directed single diasteromers of 4-fluoroglutamine having a diastereomeric excess of at least 80%. Methods of preparing the single diastereomers are also described, as well as ..AMPHIPHILIC JANUS-DENDRIMERSThe invention concerns compounds of the formula: X-(Y)t wherein: X is Formula (X), each Y is the same or different and is Formula (Y) -O-[CH2-CH(OH)-CH2-O-]m-H; or -C(OR5)3; R1, R2, R3, R6, R7, R8, R9..Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of useA recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed. M..O-methylated rapamycin derivatives for alleviation and inhibition of lymphoproliferative disordersThe present invention relates to methods of alleviating and inhibiting a Iymphoproliferative disorder in a mammal, the method comprising administering one or more rapamycin derivatives (including rapa..FN14/TRAIL FUSION PROTEINSFusion proteins which act on the TWEAK and TRAIL signaling axes are provided. The proteins are useful in the treatment or amelioration of autoimmune diseases, particularly multiple sclerosis, as well ..Novel artificial antigen presenting cells and uses theforThe invention relates to novel artificial antigen presenting cells (aAPCs). The aAPC comprises at least one stimulatory ligand and at least one costimulatory ligand where the ligands each specifically..FUNCTION AND REGULATION OF ADAMTS-1The present invention relates to ADAMTS-1 and uses thereof. The present invention also relates to fragments of ADAMTS-1 and methods of inhibiting cell growth and metastasis. The present invention also..Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the sameFusion proteins and nucleic acid molecules encoding fusion proteins are disclosed. Fusion proteins comprising non-IL-15 signal peptide linked to IL-15 protein sequences and fusion proteins comprising ..SMALLPOX DNA VACCINE AND THE ANTIGENS THEREIN THAT ELICIT AN IMMUNE RESPONSEThe present invention relates to DNA vaccines that are capable of generating a protective immune response in mammals against a pox virus, and comprises at least one DNA plasmid capable of expressing a..Disc-Like Angle-Ply Structures for Intervertebral Disc Tissue Engineering and ReplacementProvided are implant scaffolds comprising angle-ply arrays of two or more layers of substantially aligned fiber, methods of making and using said scaffolds, and kits comprising such scaffolds.Neprilysin Gene Polymorphism and Amyloid Beta Plaques in Traumatic Brain InjuryThe invention relates to methods of diagnosing risk of amyloid [beta] deposition following traumatic brain injury. More particularly, the invention relates to the discovery of a specific single nucleo..COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ICAM-1RNA interference using small interfering RNAs which are specific for the ICAM-1 gene inhibits expression of this gene. Diseases which involve ICAM-1-mediated cell adhesion, such as inflammatory and au..DNA VACCINES ENCODING HIV ACCESSORY PROTEINSImproved vaccines and methods of using the same are disclosed. Immunosuppressive compositions for treating individuals who have autoimmune diseases or transplants and methods of using the same are dis..COMPOSITIONS AND METHODS FOR REGULATING CYTOCHROME C-MEDIATED APOPTOSIS BY tRNAThe invention relates to the discovery that tRNA is a potent regulator of cell survival. tRNA regulates the interaction between cytochrome c and Apaf-1 and subsequently Apaf-1 oligomerization into an ..GENERATION OF HYPERSTABLE mRNAsProvided herein is a method for enhancing the stability of a mRNA molecule. Specifically, the invention provides methods of increasing stability or augmenting expression of mRNA or its products by ins..NON-HEMOLYTIC LLO FUSION PROTEINS AND METHODS OF UTILIZING SAMEThe present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholestero..MODIFIED ADENOVIRUS HEXON PROTEIN AND USES THEREOFThe present invention provides a method of altering the specificity of an adenovirus vector. The method involves providing an adenovirus having a capsid with a modified adenovirus hexon protein. The m..SMNDELTA7 DEGRON: NOVEL COMPOSITIONS AND METHODS OF USEThe present invention includes an isolated nucleic acid comprising a nucleic acid sequence encoding a SMN?7 degron and the encoded polypeptide. The invention also includes inhibitors of SMN?7 degron. ..METHOD OF INHIBITING BIOMATERIAL-INDUCED PROCOAGULANT ACTIVITY USING COMPLEMENT INHIBITORSMethods for reducing or eliminating biomaterial-induced procoagulant activity in blood subjected to extracorporeal treatment that exposes the blood to the biomaterial are disclosed. The methods involv..FOXP3 OLIGOMERIZATION AND INTERMOLECULAR INTERACTIONSMethods of identifying immune response modulators are disclosed. Some methods comprise identifying chemical candidates that modulate oligomerization of FOXP3 and/or fragments thereof comprising the Zi..Simian adenoviruses SAdV-36, -42.1, -42.2, AND -44 and uses thereofAn adenovirus is disclosed, having a capsid comprising a hexon protein of SAdV-42.1 or an amino acid sequence at least about 99% identical thereto, or a hybrid hexon protein. The capsid encapsidates a..DETECTION OF NUCLEIC ACIDS USING A CANTILEVER SENSORDetection of miniscule amounts of nucleic acid is accomplished via binding of target nucleic acid to probe material, composed of nucleic acid, which is bound to a sensor configured to sense mass. The ..ELECTROWETTING MICROARRAY PRINTING SYSTEM AND METHODS FOR BIOACTIVE TISSUE CONSTRUCT MANUFACTURINGApparatuses and methods for manufacturing three-dimensional, bioactive, tissue scaffold fabrications with embedded cells and bioactive materials, such as growth factors, using biomimetic structure mod..BIOADHESIVE HYDROGELSA method of forming and the resulting bioadhesive hydrogel composition for repairing or supplementing a nucleus pulposus of an intervertebral disc comprises at least a first component, a second compon..ENCAPSULATION OF MICROBUBBLES WITHIN THE AQUEOUS CORE OF MICROCAPSULESThe present invention includes a construct that comprises at least one microbubble encapsulated within the aqueous core of a microcapsule. The present invention also includes a pharmaceutical composit..PLASMA TREATMENT FOR GROWTH FACTOR RELEASE FROM CELLS AND TISSUESAspects of the present invention are related to methods comprising contacting an endothelial cell in an endothelial cell population with a non-thermal plasma to release an angiogenic growth factor. Th..FLOW-BASED ENHANCEMENT OF SPECIFICITY FOR LABEL-FREE BIOCHEMICAL ASSAYSA label-free biochemical assay, in which label-free interrogation of a target-receptor layer is performed while the target-receptor layer is subjected to a relatively strong flow of an analyte-contain..COMPOSITIONS AND METHODS FOR TREATING A DISORDER OR DEFECT IN SOFT TISSUEThe present invention encompasses methods and compositions for generating a biomimetic proteoglycan. The invention includes methods of treating a disease, disorder, or condition of soft tissue using a..SMALL DIAMETER VASCULAR GRAFT PRODUCED BY A HYBRID METHODThe present invention relates to a hybrid graft and methods of generating the hybrid graft. The hybrid graft comprises an exterior surface and a luminal surface. The luminal surface comprises a microp..PHASE TRANSITIONING HYDROGELSA method of forming and the resulting hydrogel composition comprising poly( vinyl alcohol) at a final concentration of about 20% (w/w) to about 65% (w/w) and polyethylene glycol at a final concentrati..Self-assembled proteins and related methods and protein structuresThe present invention provides user-directed construction of novel specific homo- and hetero-dimeric, and multimeric assemblages of proteins. The present invention is comprised of gene sequences that ..METHODS OF MODULATING IMMUNE FUNCTIONPresented herein are therapeutic agents that modulate one or more immune functions and uses of such therapeutic agents in the prevention, treatment and management of diseases. In one aspect, the thera..MEASUREMENT OF MITOCHONDRIAL MEMBRANE POTENTIAL TO ASSESS ORGAN DYSFUNCTIONThe present invention relates to the field of organ transplantation. More specifically, the present invention provides methods for predicting organ function after transplantation. In certain embodimen..PROGRAMMABLE MULTISPECTRAL ILLUMINATION SYSTEM FOR SURGERY AND VISUALIZATION OF LIGHT-SENSITIVE TISSUESAn observation system for viewing light-sensitive tissue includes an illumination system configured to illuminate the light-sensitive tissue, an imaging system configured to image at least a portion o..BIOMARKERS FOR MYOCARDIAL ISCHEMIAThis invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial ischemia;..COMPOSITIONS AND METHODS FOR IMPLANTATION OF ADIPOSE TISSUE AND ADIPOSE TISSUE PRODUCTSThe invention provides compositions and methods for the preparation of biocompatible biomaterials from adipose tissue. Biocompatible biomaterials are cellular or acellular biomaterials. The invention ..POTENT IMMUNOSUPPRESSIVE AGENTS, DERIVATIVES AND USESProvided herein include compositions, all related stereoisomers as well as pharmaceutically acceptable salts provided as simplified analogs of pateamine A, in which the analogs generally are devoid of..Method for detecting cellular proliferative disordersA novel T-type calcium channel (CACNA1G) is provided, as are polynucleotides encoding the same. CACNA1G has been implicated in cellular proliferative disorders. More specifically, it has been observed..INDUCTION OF THYROID IODIDE-HANDLING GENE EXPRESSION IN HUMAN CANCERSDual suppression of the MAP kinase and PI3K/Akt pathways showed synergistic or greatly enhanced anti-melanoma cell effects, compared to suppression of a single pathway, including the inhibition of cel..BRAIN ENDOTHELIAL CELL EXPRESSION PATTERNPROBLEM TO BE SOLVED: To provide new techniques for isolating brain endothelial cells (ECs) and evaluating gene expression patterns to gain a better understanding of brain tumor angiogenesis. ; SOLUTI..Biological pacemakerDisclosed are methods and systems for modulating electrical behavior of cardiac cells. Preferred methods include administering a polynucleotide or cell-based composition that can modulate cardiac cont..SECRETED AND CELL SURFACE GENES EXPRESSED IN BENIGN AND MALIGNANT COLORECTAL TUMORSSerial analysis of gene expression (SAGE) was used to identify transcripts encoding secreted or cell-surface proteins that were expressed in benign and malignant tumors of the colorectum. A total of 2..USE OF BIOMARKERS FOR DETECTING OVARIAN CANCERThe present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measure..BIOMARKER FOR IDENTIFICATION OF MELANOMA TUMOR CELLSThis invention relates to use of neuropilin-2 as a novel biomarker and therapeutic target for melanoma. The presence of neuropilin-2 can be used as a biomarker for diagnosing and detecting individuals..DETECTION OF HEAD AND NECK CANCER USING HYPERMETHYLATED GENE DETECTIONMethods and kits for detection of a cell proliferative disorder, such as head and neck cancer are provided utilizing analysis of the methylation state of targeted genes or regulatory regions of genes ..SITE-SPECIFIC MODIFICATION OF PROTEINSMethods and compositions for site-specific modification of amino acids, peptides, polypeptides and proteins are disclosed.COMPOSITIONS AND METHODS FOR THE TREATMENT OF OCULAR OXIDATIVE STRESS AND RETINITIS PIGMENTOSAOxidative damage contributes to cone cell death in retinitis pigmentosa and death of rods, cones, and retinal pigmented epithelial (RPE) cells in ocular oxidative stress related diseases including age..CIRCULATING MUTANT DNA TO ASSESS TUMOR DYNAMICSDNA containing somatic mutations is highly tumor specific and thus, in theory, can provide optimum markers. However, the number of circulating mutant gene fragments is small compared to the number of ..BIOMARKERS FOR MELANOMAThe present invention relates to methods of determining melanoma status in a subject. The invention also relates to kits for determining melanoma status in a subject. The invention further relates to ..LATERAL FLOW DEVICE FOR DIAGNOSING MICROBIAL INFECTIONSFungal infections are difficult to diagnose. The most common filamentous fungal infection, aspergillosis, carries with it a high mortality. Culture of the organism is difficult and obtaining samples, ..HYDROGEL-GRAFTED DEGRADABLE NERVE GUIDESThe present invention is directed to the compositions and methods of preparing hydrogel-grafted nerve guides for peripheral nerve regeneration. Particularly, the present invention describes the nerve ..COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER USING TISSUE-SPECIFIC ONCOLYTIC ADENOVIRUSESThe present invention includes the use of a nucleic acid sequence encoding an shRNA to target RNA interference against a cellular factor where such use can enhance oncolytic adenovius replication. The..ALBUMIN-BOUND PROTEIN/PEPTIDE COMPLEX AS A BIOMARKER FOR DISEASEMethods and kits for diagnosis and prognosis using biomarkers comprising albumin-bound protein/peptide complex (ABPPC).PRODRUG ACTIVATION IN CANCER CELLS USING MOLECULAR SWITCHESThe present invention features a novel protein engineering strategy by combining the domains of two independent proteins into a molecular switch. The invention features polypeptides comprising a prodr..METHODS FOR PROMOTING FUSION AND REPROGRAMMING OF SOMATIC CELLSThe invention features methods for reprogramming somatic cells by treating the cells with one or more agents to induce de-differentiation, in particular by targeting demethylase and methyltransferase ..PATHWAYS UNDERLYING PANCREATIC TUMORIGENESIS AND AN HEREDITARY PANCREATIC CANCER GENEThere are currently few therapeutic options for patients with pancreatic cancers and new insights into the pathogenesis of this lethal disease are urgently needed. To this end, we performed a comprehe..METHODS AND KITS FOR IDENTIFICATION OF ANTI-EXCITOTOXIC COMPOUNDSThe instant invention provides methods and kits for screening for anti-excitotoxic compounds which increase the total amount of EAAT-I protein or the surface amount of EAAT-I protein.TARGET AND METHOD FOR INHIBITION OF BACTERIAL RNA POLYMERASETarget and method for inhibition of bacterial RNA polymerase disclosed are targets and methods for specific binding and inhibition of RNAP from bacterial species.METHODS FOR OBTAINING BIOACTIVE COMPOUNDS FROM PHYTOPLANKTONPhytoplankton represent a potential source of bioactive compounds. The present disclosure provides, inter alia, methods for identifying glycerolipids and apoptosis- inducing sphingosine-like lipids fr..GRAFT POLYMERS FOR ENHANCED INTRACELLULAR DELIVERY OF ANTISENSE MOLECULESInnovative graft polymers designed for the efficient delivery of antisense molecules into biological cells and for maintaining the biological activity of these molecules while in serum and other aqueo..PREPARATION AND USES OF POLYARYLATESThe present invention is directed to polyarylates comprising repeating units having the structure: as well as their preparation and use as cell growth substratesHIGH MOLECULAR WEIGHT POLYMERS, DEVICES AND METHOD FOR MAKING AND USING SAMEAnhydride polymers that release active or activatable agent(s) have pre-selected properties such as molecular weight, flexibility, hardness, adhesiveness, and other valuable properties. The polymers a..LITHIUM STIMULATION OF CORD BLOOD STEM CELL PROLIFERATION AND GROWTH FACTOR PRODUCTION.The present invention provides methods for expanding human umbilical cord blood stem cells and methods for stimulating growth factor production by cord blood stem cells using an in vitro cell culture ..TOPOISOMERASE-TARGETING AGENTSThe invention provides compounds of formula I or formula II: wherein: the bond represented by <img id="CUSTOM-CHARACTER-00001" he="1.02mm" wi="4.23mm" file="US20090258890A1-20091015-P00001.TIF" img-co..Transgenic plants expressing L3 delta proteins are resistant to trichothecene fungal toxinsDisclosed are specific mutants of L3 and transgenic plants that produce them. The plants exhibit increased resistance to fungal toxins that target ribosomal L3 protein. Also disclosed are transgenic p..Non-cytotoxic PAP mutantsDisclosed are PAP mutants that are less toxic than wild type PAP and that exhibit depurination activity. Also disclosed are transgenic plants that produce the PAP mutants, and methods for preparing th..Soybean Oil Based Oxygen Carrying Emulsion for Massive Blood LossVivaSure is a new treatment for shock from massive blood loss. It is based on soybean oil and is therefore biodegradable. It refills lost vascular volume, protects from free radicals, absorbs toxins a..TOPOSIOMERASE INHIBITORSThe invention provides compounds of formula (I): wherein A, B, W, Y, Z, R1, R3 and R4 have any of the meanings defined in the specification and their salts. The invention also provides pharmaceutical ..SWITCH-REGION: TARGET AND METHOD FOR INHIBITION OF BACTERIAL RNA POLYMERASEThe invention provides a target and methods for specific binding and inhibition of RNA polymerase from bacterial species. The invention provides methods for identifying agents that bind to a bacterial..MEDIA CONDITIONING FOR IMPROVING GENE DELIVERY EFFICIENCY TO DIFFERENTIATING EMBRYONIC STEM CELLSThe present invention provides systems and methods for improving the efficiency of a transient gene delivery system to differentiating embryonic stem (ES) cells by serum starving the targeted cells fo..HIGH-THROUGHPUT BIOMARKER SEGMENTATION UTILIZING HIERARCHICAL NORMALIZED CUTSA method and apparatus for obtaining segmented images of the stained regions may comprise quantifying the extent of the presence of staining of a biomarker in an original image of a sample, which may ..MONOMERS AND PHASE-SEPARATED BIOCOMPATIBLE POLYMER COMPOSITIONS PREPARED THEREFROM FOR MEDICAL USESThe invention relates to novel monomers of Formula (I) useful for preparation of phase-separated biocompatible polymers or polymer compositions. These polymers or polymer compositions may be bioresorb..SYNTHESIS OF CYCLIC DIGUANOSINE MONOPHOSPHATE AND THIOPHOSPHATE ANALOGS THEREOFThe invention provides methods for the synthesis of cyclic dinucleotides and thiophosphate analogs thereof as well as a new family of analogs of cyclic diguanosine monophosphate that includes a series..STEROSPECIFIC CARBONYL REDUCTASESStereospecific carbonyl reductases SCR1, SCR2, and SCR3 are described herein as are nucleotide sequences that encode these reductases. These stereospecific carbonyl reductases have anti-Prelog selecti..OREGANO AND MINT ANTI-INFLAMMATORY COMPOSITIONS AND METHODSThe present invention relates to bioactivity-guided isolation and identification of bioactive compounds from oregano and mint plants, in particular, rosmarinic acid, oleanolic acid and ursolic acid, a..Interspecific cornus hybrid designated KF 111-1An advanced generation interspecific hybrid of Cornus kousa and C. florida that is distinguished by its exceptionally high vigor, attractive foliage, very floriferous display of white floral bracts, h..BIORESORBABLE POLYMERS SYNTHESIZED FROM MONOMER ANALOGS OF NATURAL METABOLITESNew bioresorbable polymers are synthesized from monomer analogs of natural metabolites In particular, polymers are polymerized from analogs of amino acids that contribute advantageous synthesis, proce..Disease Resistant Transgenic PlantsProvided are transgenic plants, seed and plant parts which display increased resistance to fungal disease or mycotoxin. Also provided are methods of making transgenic plants with increased resistance ..Methods for Obtaining Bioactive Compounds from PhytoplanktonPhytoplankton represent a potential source of bioactive compounds. The present disclosure provides, inter alia, methods for identifying glycerolipids and apoptosis-inducing sphingosine-like lipids fro..COMBINATION THERAPY TO IMPROVE DRUG EFFICIENCYThe instant invention provides methods for increasing drug bioavailability and/or preventing multi-drug resistance through inhibition of ABCG2 protein by caffeine or caffeine analogs.MODULAR TRIPLE-HELICAL COLLAGEN-LIKE PRODUCTSRecombinant bacterial triple-helical collagen-like proteins comprising two or more repetitive sequences of Gly-Xaa-Yaa yielding high-stability polymeric constructs without the need for post-translatio..Cytokines and Genes Differentially Affected by TNF BlockersThe present invention is directed to cytokines and genes that are differentially affected by TNF blockers and the use of these genes and cytokines to help asses the TB risks of new immunosuppressive t..Proteins, Nucleic Acids Encoding the Same, and Associated Methods of UseDisclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to th..NOVEL HUMAN LYSOSOMAL PROTEIN AND METHODS OF ITS USEThe gene associated and causative of classical late infantile neuronal ceroid lipofuscinosis (LINCL), CLN2, has been identified and characterized. The translation product of this gene is a novel prote..Labeled Biomolecular Compositions and Methods for the Production and Uses ThereofDisclosed herein is a set of E. coli single-protein production (SPP) technologies with protein NMR (SPP-NMR) for (i) using isotope-enriched membrane proteins produced with the SPP system in screening ..TYPE I INTERFERON ANTAGONISTSDisclosed in certain embodiments is a method of preparing a Type 1 interferon antagonist comprising modifying a Type 1 interferon at the site of interaction with the interferon receptor subunit IFNAR-..NOVEL TOXIN-ANTITOXIN SYSTEMDisclosed in certain embodiments is a method of inhibiting cell function comprising inducing the expression of a mRNA interferase that cleaves mRNA at GCU.Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acidsA method of sorting mixtures of nucleic acid strands comprising hybridizing the strands to an array of immobilized oligonucleotides, each of which includes a constant segment adjacent to a variable se..Salivary Bioassay for Early Detection of Bone LossThe present invention is directed to methods to detect and diagnose osteoporosis and periodontal disease using salivary biomarkers.METHODS AND COMPOSITIONS FOR TREATING CANCERThe present invention provides methods of treating cancer using 2-amino-6-trifluoromethoxybenzothiazole (riluzole). In one aspect, the present invention provides methods of reducing cancer cell growth..NOVEL MODIFICATION OF IMMUNOMODULATORY PROTEINMethods of inhibiting annexin I induced apoptosis by contacting a cell population containing a TRPM7/ChaK1 kinase with an effective amount of a composition containing an inhibitor for the kinase.A METHOD OF USING AN EXTRACELLULAR MATRIX TO ENHANCE CELL TRANSPLANT SURVIVAL AND DIFFERENTIATIONProvided is a matrix for promoting survival and differentiation of cells transplanted thereon, comprising a base matrix and a cell-made matrix thereon. Methods and means for making and using same are ..TELOMERASE REVERSE TRANSCRIPTASE VARIANTThe present invention relates to nucleic and amino acid sequences of a novel variant of the telomerase reverse transcriptase. More particularly, the present invention is directed to a novel variant of..TARGETING BACTERIAL SUICIDE PATHWAYS FOR THE DEVELOPMENT OF NOVEL ANTIBIOTICSThe invention provides methods for identifying an agent which prevents or partially prevents an antitoxin from forming a complex with its cognate toxin, comprising contacting a potential agent with a ..THE USE OF PROTEIN S FUSION FOR PROTEIN SOLUBILIZATIONThe invention provides vectors containing a multiple cloning site comprising a PrS tag or a PrS2 tag from Myxococcus xanthus. Methods are provided for enhancing solubility of a target protein using Pr..TARGETING TUMOR CELLS WITH CHEMOTHERAPEUTIC AGENTS CONJUGATED TO MATRIPTASE ANTIBODIESThe present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expres..IMAGING INDIVIDUAL mRNA MOLECULES USING MULTIPLE SINGLY LABELED PROBESA method for probing a target sequence of messenger ribonucleic acid molecules (mRNA's) in a fixed, permeabilized cell, said target sequence including at least 30 non- overlapping probe binding region..COMPOSITIONS COMPRISING MG29 NUCLEIC ACIDS, POLYPEPTIDES AND ASSOCIATED METHODS OF USEDisclosed herein are compositions and methods for treatment of muscle dysfunction (including sarcopenia) and other diseases involving skeletal musle, including age-related muscle dysfunction. In addit..ANTI-SENSE MICRORNA EXPRESSION VECTORSThe present invention relates to an alternative strategy for expressing the antisense sequence of a miRNA. This system allows for continuous production of the antisense sequence and subsequently compl..Immunotherapy for Unresectable Pancreatic CancerThe present invention provides a novel cancer immunotherapy comprising a vaccination schedule of both intratumoral and systemic injections followed by peripheral boost injection. The immunotherapy can..Multiplex Screening for Pathogenic Hypertrophic Cardiomyopathy MutationsThis invention relates to a new method of screening for hypertrophic cardiomyopathy. In certain embodiments, the invention comprises a method of screening for hypertrophic cardiomyopathy comprising de..Cold Shock Protein Compositions and Methods and Kits for the Use ThereofThe present invention provides cold shock protein-containing compositions for improved DNA synthesis reactions with improved reactivity, methods for synthesizing DNA using such compositions, kits for ..Compositions and methods for enzymatic detachment of bacterial and fungal biofilmsIsolated nucleic acid sequences and amino acid sequences for soluble -N-acetylglucosaminidase or active fragments or variants thereof which promote detachment of bacterial cells from a biofilm are pro..TISSUE ENGINEERED FIBROCARTILAGE REPLACEMENTFibrocartilage implants characterized by circumferential fiber networks embedded in arcuate or torroidal scaffolds with orthogonal fiber networks embedded therein to prevent separation of the circumfe..Chemoprevention of Colorectal Cancer by Mesalamine/SulfasalazineA method for preventing or treating colorectal cancer in a patient possessing human tropomyocin isoform TC22 is presented. Also presented is a method for evaluating TC22 expression reduction activity ..PROTEINS EXPRESSED BY MYCOBACTERIUM TUBERCULOSIS AND NOT BY BCG AND THEIR USE AS VACCINESThe present invention is directed to proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as vaccines.STRATEGY FOR HOMO- OR HETERO-DIMERIZATION OF VARIOUS PROTEINS IN SOLUTION AND IN CELLThe present invention describes a chimeric polypeptide comprising a first portion comprising a receptor domain, wherein the receptor domain comprises an intracellular region and a transmembrane region..NOVEL COMPOUNDS FOR INHIBITING EEF2 KINASE ACTIVITYThe present invention discloses novel compounds for inhibiting eEF2 kinase and methods of use thereof.E2F AS A TARGET FOR TREATMENT OF HORMONE REFRACTORY PROSTATE CANCERThe instant invention provides amino acid sequences competing with E2F for DNA binding. Methods of using said amino acid sequences for treatment of hormone-refractory prostate cancer are also provided..STRUCTURE OF A PROTEIN PHOSPHATASE 2A HOLOENZYME: INSIGHTS INTO TAU DEPHOSPHORYLATIONEmbodiments of the present invention relate to crystals and atomic coordinates for PP2A, as well as methods for using these atomic coordinates to prepare modulators of PP2A and inhibitors prepared usi..DEMETHYLATION AND INACTIVATION OF PROTEIN PHOSPHATASE 2AEmbodiments of the present invention relate to atomic coordinates for PME-1 alone or in complex with PP2A, as well as methods for using these atomic coordinates to prepare inhibitors of PME-1 and/or P..NANOPARTICLES FOR PHOTODYNAMIC THERAPYEmbodiments of the invention include nanoparticulate products of a flash nanoprecipitation process, the products comprising, in combination, pre-formed nanoparticles having properties of an upconversi..IDENTIFICATION OF BACTERIAL AUTOINDUCER AND USE IN TREATING BACTERIAL PATHOGENICITYA bacterial autoinducer, CAI-I, was purified and its structure identified. Methods for synthesis of the autoinducer and its analogues were elucidated. Methods of using the autoinducer or its analogues..NANO-PARTICLE SURFACE MODIFICATIONOxide, oxysulfide, halide or phosphate host particles with a self-assembled organo- phosphonate monolayer covalently bonded thereto. Methods for coating the host particles and use of rare earth ion-do..MODULATORS OF PROTEIN PHOSPHATASE 2A AND PP2A METHYL ESTERASEThe disclosure relates to modulation of protein phosphorylation, including information derived from the structures and activities of the proteins designated protein phosphatase 2A (PP2A) and PP2A meth..Nanochannel arrays and their preparation and use for high throughput macromolecular analysisNanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecu..IAP BINDING COMPOUNDSCompounds that bind cellular IAPs (inhibitor of apoptosis proteins) are disclosed. The compounds are mimetics of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABOLO, Hid, Grim an..INHIBITORS OF MTOR KINASE AS ANTI-VIRAL AGENTSThe present invention provides methods and compositions for treating or preventing viral infections using modulators of host cell enzymes relating to mTOR. The invention also provides methods and comp..SiRNA PHOSPHOLIPID CONJUGATEsiRNA-conjugated liposomes and micelles, methods of making such conjugates, and methods of using such conjugates, such as for the delivery of siRNA to cells to reduce expression of target polypeptides..STEROIDAL ANTI-HORMONE HYBRIDSDisclosed are novel compounds and compositions for inhibition of androgen and estrogen receptor signaling, methods for inhibiting androgen signaling, methods for inhibiting estrogen signaling, methods..MIXED MICELLES INCLUDING AMPHIPATHIC CONJUGATES OF RNA AGENTS, AND USES THEREOFDisclosed are improved pharmaceutical formulations for the delivery of RNA interference agents, such as antisense RNA, micro-RNA and siRNA. The formulations employ mixed micelles including amphipathic..METHOD OF PREPARING ADENOSINE-RESISTANT ANTI-TUMOR T LYMPHOCYTES FOR ADOPTIVE IMMUNOTHERAPYIn the past, adoptive immunotherapy often failed because the transferred immune cells were inactive in vivo. This disclosure provides a method of producing immune cells that are highly active in vivo...IMAGING NEUROLEPTIC COMPOUNDSA method for identifying typical and atypical antipsychotics based on their ability to reduce neuronal/glial activity in specific brain regions upon dopaminergic neurotransmission is disclosed.COLLAGEN FIBRILLAR CONSTRUCTIONMethods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engine..POLYCYCLIC COMPOUNDS FOR USE IN TREATING OCULAR NEURODEGENERATIVE DISEASESDescribed herein are various compounds for treatment of ocular neurodegenerative diseases, including but not limited to glaucoma and diabetic retinopathy. The compounds described herein can act to att..METHODS OF TREATING FUNGAL INFECTIONSMethods of identifying compounds that potentiate the activity of antifungal agents, potentiators identified by these methods, and methods of using potentiators are disclosed.METHODS OF TARGETING CELLS FOR DIAGNOSIS AND THERAPYMethods of making bispecific binding complexes and nanopolymers coupled to detection and/or therapeutic agents are disclosed. Also disclosed are methods of using such bispecific binding complexes and ..SELF-ASSEMBLING MICELLE-LIKE NANOPARTICLES FOR SYSTEMIC GENE DELIVERY.Nanoparticles containing nucleic acid and suitable for use as in vivo delivery agents for nucleic acids are provided. The nanoparticles use a covalent conjugate of a polycation such as polyethylenimin..MODULATORS OF NUCLEAR RECEPTOR CO-REGULATORY PROTEIN BINDINGDisclosed are novel compounds and compositions for inhibition of androgen and estrogen receptor signaling, methods for inhibiting androgen signaling, methods for inhibiting estrogen signaling, methods..Biomarkers for Diabetes, Obesity, and/or HypertensionMethods of identifying subjects having, or at risk of developing, diabetes, obesity, and/or hypertension are disclosed, as well as methods of identifying biomarkers for diabetes, obesity, and/or hyper..Methods and Compounds for Modulating Cannabinoid ActivityDisclosed are compounds and compositions that inhibit the action of monoacylglycerol lipase (MGL) and fatty acid amide hydrolase (FAAH), methods of inhibiting MGL and FAAH, methods of modulating canna..T CELL RECEPTOR-DEFICIENT T CELL COMPOSITIONSThe invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one e..NUTRACEUTICAL COMPOSITION AND METHODS FOR PREVENTING OR TREATING MULTIPLE SCLEROSISThe present invention embraces nutraceutical compositions containing isolated Bacteroides fragilis capsular polysaccharide A for use in methods of preventing or treating multiple sclerosis.MICRORNA-10 ANTAGONISTS AND MICRORNA-10 TARGETS FOR USE IN THE TREATMENT OF A GLIOMAThe present invention embraces microRNA-antagonists and activators of homeobox D10 protein; Zinc finger, MYND domain containing 11 protein; or RB1-inducible coiled-coil 1 protein for use in decreasing..ATTENUATED URACIL AUXOTROPH OF AN APICOMPLEXAN AND USE THEREOFUracil auxotroph mutants of apicomplexans are provided which lack a functional carbamoyl phosphate synthase II (CPSII) enzyme. Also provided are T. gondii autoxtroph mutants which express exogenous an..Compositions and methods for inhibiting the synthesis or expression of MMP-1The present invention relates to the specific inhibition of matrix metalloproteinase 1 (MMP-1) using agents which inhibit the synthesis or expression of MMP-1. Such agents are useful for suppressing i..Methods for diagnosing and treating neuroendocrine cancerThe present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods fo..CDDO-COMPOUNDS AND COMBINATION THERAPIES THEREOFCDDO-compounds in combination with other chemotherapeutic agents induce and potentiate cytotoxicity and apoptosis in cancer cell. One class of chemotherapeutic agents include retinoids. Cancer therapi..COMPOSITIONS AND METHODS FOR INHIBITING THE INTERACTION BETWEEN CFTR AND CALThe present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides..SELECTION OF CELLULOLYTIC MICROBES WITH HIGH GROWTH RATESMethods for obtaining cellulolytic microbes with high growth rates are disclosed. For example, C. thermocellum colonies with growth rates higher than 0.17 hr " 1 have been obtained by the present meth..COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF PANCREATIC DUCTAL CANCERThe present invention includes compositions and methods for diagnosing and treating pancreatic cancer. These compositions and methods are based on the finding that 14-3-3s protein is secreted from pan..MOLECULAR SIGNATURES FOR DIAGNOSING SCLERODERMAThe present invention features methods for classifying, determining severity, and predicting clinical endpoints of scleroderma based upon the expression of selected biomarker genes.PREVENTION OR TREATMENT OF IMMUNE-RELEVANT DISEASE BY MODIFICATION OF MICROFLORAL POPULATIONSThe present invention is a method for preventing or treating an immune -relevant disease by modulating commensal microbiota populations via antibiotics, exogenous microbiota and/or probiotics.BIOACTIVE MOLECULES PRODUCED BY PROBIOTIC BACTERIA AND METHODS FOR ISOLATING AND USING THE SAMEThe present invention is a method for isolating bioactive molecules secreted by probiotic bacteria such as Lactobacillus rhamnosus, and methods for using such bioactive molecules to decrease replicati..Bis-carbazole DNA intercalating agents for antitumor therapyThe present invention is a DNA intercalating agent represented by the structure Y-Z-Y, wherein Y is an anti-tumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, containing at ..MICRORNA BIOMARKERS FOR HUMAN BREAST AND LUNG CANCERThe present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.METHOD FOR IDENTIFYING AN AGENT THAT INHIBITS CANDIDA ALBICANS -MEDIATED HOST CELL DIFFERENTIATIONThe present invention features a method for identifying an agent that inhibits Candida albicans- mediated differentiation of keratinocytes. Agents identified by the screening assay of the invention fi..CAVEOLIN 1-REPORTER PROTEIN KNOCK-IN MOUSEThe present invention embraces a transgenic mouse whose genome harbors a nucleic acid molecule encoding caveolin-1 fused in-frame with a reporter. To control expression of the Cavl-reporter, the nucle..Microrna-21 antagonists and its target PDCD4 for use in the treatment of a gliomaThe present invention embraces microRNA-21 antagonists and activators of Programmed Cell Death 4 for use in decreasing glial tumor cell proliferation and treating glioma.CELL CULTURE HYDROGEL WITH pH INDICATORThe invention provides devices, compositions and methods for maintaining conditions in a cell culture and for measurement of conditions in the cell culture. In particular, the invention provides hydro..COMPOSITIONS AND METHODS FOR TREATING CANCER WITH DACARBAZINE NANOEMULSIONSA uniform microfluidized nanoemulsion is disclosed containing an anti-cancer agent, such as dacarbazine. The microfluidized nanoemulsion improves the combination's cell membrane permeability by at lea..SYNERGETIC FUNCTIONALIZED SPIRAL-IN-TUBULAR BONE SCAFFOLDSAn integrated scaffold for bone tissue engineering has a tubular outer shell and a spiral scaffold made of a porous sheet. The spiral scaffold is formed such that the porous sheet defines a series of ..STRUCTURAL/BIOLOGICAL IMPLANT SYSTEMA structural/biological implant and method of use. The implant being utilized as a single or multiple staged system that is designed to encourage new alveolar bone growth with or without the need to o..BIOSENSOR FOR CONTINUOUS MONITORING OF METABOLITES AND PROTEINS AND METHODS OF MANUFACTURE THEREOFA biosensor comprises a substrate; a reference electrode; a working electrode; a counter electrode; and a plurality of permeability adjusting spacers. The reference electrode, the working electrode an..METHODS OF INHIBITING VASCULAR PERMEABILITY AND APOPTOSISAgonists of vascular endothelial sphingosine-1-phosphate receptors are described. Compounds such as FTY720 can be phosphorylated by sphingosine kinase-2 into the phosphorylated forms which serve as sp..DIFFERENTIATION OF HUMAN EMBRYONIC AND INDUCED PLURIPOTENT STEM CELLSThe invention relates to culture systems, methods, and conditions that allow pluripotent undifferentiated hESCs or iPSCs to progressively and uniformly differentiate into cells of the chondrogenic lin..FLUORINATED LIPIDS AND METHODS OF USEThe invention provides methods and compounds for delivering agents to cells. The compounds can include a fluorinated lipid, a linker, and an agent for delivery to a cell.POLYMERIC MICROSPHERESThe invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell with ..METHODS AND COMPOSITIONS FOR MODULATING MEMBRANE POTENTIAL TO INFLUENCE CELL BEHAVIORThe present invention provides methods for controlling proliferation, differentiation, and/or migration of cells by modulating membrane potential through an endogenously expressed channel protein. The..MEASUREMENT OF BIOLOGICAL TARGETSAn integrated imaging system, e.g., a microsystem, for detecting activity of a biological target, for example, in response to a stimulus, includes an array of pixels arranged on a substrate, each pixe..SMAD PROTEINS CONTROL DROSHA-MEDIATED MIRNA MATURATIONThe invention, in some aspects, relates to compositions and methods useful for modulating expression of miRNAs that are regulated by the TGF-ss/BMP signaling pathway. In some aspects, the invention re..ANTI-APOPTOTIC AGENTS AND USES THEREOFThe invention generally relates to the use of parasite-derived neurotrophic factor (PDNF), or a fragment of PDNF, to reduce cell apoptosis. The PDNF or PDNF fragment is provided in the cytoplasm of a ..SILK BIOMATERIAL AND METHOD OF USE THEREOFThe present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such..CATIONIC CONTRAST AGENTS AND METHODS OF USE THEREOFThe present invention provides compounds useful as contrast agents, such as for the CT imaging of cartilage tissue. The contrast agents are generally iodinated organic molecules that are positively ch..ENGINEERED ENZYMATICALLY ACTIVE BACTERIOPHAGE AND METHODS FOR DISPERSING BIOFILMSThe present invention is directed to engineered enzymatically active bacteriophages that are both capable of killing the bacteria by lysis and dispersing the bacterial biofilm because they have been a..NANOCHANNEL-BASED SENSOR SYSTEM FOR USE IN DETECTING CHEMICAL OR BIOLOGICAL SPECIESA sensor system for detecting a chemical or biological species includes a sensing element and a bias and measurement circuit. The sensing element includes nanochannels, each having an outer surface fu..ALIEN SEQUENCESThe present invention provides sequences and reagents for preparing microarrays with internal controls. Specifically, the present invention defines and provides sequences that are not present in the h..METHOD FOR BACTERIAL LYSISThe present invention is directed to a microfluidic device for lysis of cells, such as bacteria and microorganisms. In particular, the present invention relates to microfluidic devices and methods of ..HIGH MAGNIFICATION SPECTRAL REFLECTANCE BIOSENSING WITH DISCRETE LIGHT SOURCESA spectral reflectance imaging device for detecting biomolecular targets includes an illumination source that illuminates a substrate with a plurality of separate wavelengths of incoherent light. The ..BACTERIOPHAGES EXPRESSING ANTIMICROBIAL PEPTIDES AND USES THEREOFThe present invention is generally related to engineered bacteriophages expressing antimicrobial peptides or lytic enymes or fragments thereof for targeting a broad spectum of bacterial hosts, and for..NUCLEIC ACID SUPPORTED PROTEIN COMPLEMENTATIONThe present invention is directed to novel methods for in vitro and in vivo detection of target nucleic acid molecules, including DNA and RNA targets, as well as nucleic acid analogues. The present in..ISOLATION OF RNADisclosed herein are methods for purification of RNA from a sample. The method involves preparing the sample in a solution of lysis buffer, depositing it into a first end of a lysis straw such that th..SEQUENCE PRESERVED DNA CONVERSIONDescribed herein are inexpensive high throughput methods to convert a target single stranded DNA (ssDNA) such that each nucleotide (or base) adenine (A), thymine (T), guanine (G) and cytosine (C) is c..NUCLEIC ACID CLONINGThe present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be eas..BACTERIOPHAGES EXPRESSING AMYLOID PEPTIDES AND USES THEREOFThe present invention generally relates to engineered bacteriophages which express amyloid peptides for the modulation (e.g. increase or decrease) of protein aggregates and amyloid formation. In some ..BIOREACTIVE AGENTSThis invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, ..ANTIMICROBIAL IONIC LIQUIDSCertain aspects of the present invention relate to compositions, formulations, and use of ionic liquids as antimicrobial agent (e.g. as antibacterial and/or antifungal agents). In certain embodiments,..MELANOMA BIOMARKER AND METHODS OF USESThe present invention relates to the use of TROY, also called tumor necrosis factor receptor superfamily, member 19 (TNFRSF19) also called toxicity and JNK inducer (TAJ), in diagnosis and therapy of n..LABEL-FREE SENSING OF PNA-DNA COMPLEXES USING NANOPORESEmbodiments disclosed herein relate to a method of detecting specific DNA sequences and the application of this method in the detection of pathogens, viruses, drug-resistant pathogens, genomic variati..CHROMOSOME THERAPYThe present invention features compositions and methods for introducing, into cells, nucleic acids whose expression results in chromosomal silencing. The nucleic acids are targeted to specific chromos..NUCLEIC ACID SILENCING AGENT-PROTEIN CONJUGATES AND USE THEREOF FOR TREATING HCV-RELATED DISORDERSA method of using a complex or a molecule comprising a targeting moiety to deliver a second molecule effectively to HCV or to a cell being infected or having the potential to be infected by HCV, resul..TRYPTOPHAN AS A FUNCTIONAL REPLACEMENT FOR ADP-RIBOSE-ARGININE IN RECOMBINANT PROTEINSA method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one ..STABILIZED LIPOSOME COMPOSITIONS AND RELATED METHODS OF USELiposome compositions and related methods of preparation which can comprise one or a plurality of biopolymer components.MEASURING TISSUE OXYGENATIONMethods and systems for calculating tissue oxygenation, e.g., oxygen saturation, in a target tissue are disclosed. In some embodiments, the methods include: (a) directing incident radiation to a targe..TOLL-LIKE RECEPTOR-BASED BIOSENSORSCompositions and methods for detecting Toll-like receptor binding to ligands and test compounds are disclosed herein.INTERLEUKIN 6 AND TUMOR NECROSIS FACTOR ALPHA AS BIOMARKERS OF JNK INHIBITIONBiomarkers for JNK inhibition are described that can be used for monitoring effectiveness of JNK inhibitors and monitoring treatment with JNK inhibitors.ENHANCED TRANSPORT USING MEMBRANE DISRUPTIVE AGENTSCompositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are de..METHODS AND COMPOSITIONS TO REDUCE OXIDATIVE STRESSThe invention relates to therapeutic applications for compositions that reduce the level of oxidative stress on cells in vivo or in vitro. The invention describes methods for improving the therapeutic..Toll-Like Receptor 9 ModulatorsTLR9 is localized to endoplasmic reticulum and upon stimulation with a TLR9 ligand, is transported to a tubular lysosomal compartment as is CpG-DNA. Furthermore, it is shown that TLR9 and CpG-DNA dire..METHODS FOR MICROBIAL PRODUCTION OF TERPENOIDSThe invention relates to recombinant expression of terpenoid synthase enzymes and geranylgeranyl diphosphate synthase (GGPPS) enzymes in cells and the production of diterpenoids.Methods and compositions for enhancing the efficacy and specificity of RNAiA method of enhancing the efficacy of an siRNA duplex, or promoting entry of an antisense strand of an siRNA duplex into a RISC complex, the siRNA duplex comprising the antisense strand and a compleme..MULTIPURPOSE MICROFLUIDIC DEVICE FOR MIMICKING A MICROENVIRONMENT WITHIN A TUMORThe present application relates generally to a novel microfluidic device for the in it propagation of neoplastic cellagregates under conditions that mimic the physiological microenvironment found in t..COMPLEMENT FACTOR H-BASED ASSAYS FOR SERUM BACTERICIDAL ACTIVITY AGAINST NEISSERIA MENINGITIDISAssays for detection of bactericidal anti-Neisserial antibodies using a factor H polypeptide having a human amino acid sequence that mediates binding to Neisserial factor H binding protein (fhBp) are ..STAPHYLOCOCCUS DETECTION ASSAYSProvided herein are methods, kits, and compositions related to nucleic acid detection that allow the detection and discrimination of various Staphylococcus species and types. In particular, provided h..NUCLEIC ACID PROCESSING METHODS, KITS AND DEVICESBiological samples containing nucleic acids, RNA and DNA, are freed from bound proteins by incubation with a chaotropic agent such as a guanidium salt, and the mixture is readied for further processin..PRIMERS, PROBES AND METHODS FOR NUCLEIC ACID AMPLIFICATIONHomogenous detection during or following PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled primers and probes, improves reproducibility and quantif..REAGENTS AND METHODS FOR PCRModified double-stranded oligonucleotides that have terminal regions on each of their strands, that have a hybrid length of 6-50 nucleotides long, that have a melting temperature Tm of at least 32 DEG..Reagents and methods for improving reproducibility and reducing mispriming in PCR amplificationAn additive for preventing mispriming in polymerase chain reaction (PCR) amplifications and assays comprising a hairpin oligonucleotide having a stem duplex greater than six nucleotides in length and ..METHODS OF USING MIR-199A AS A MARKER AND SEQUENCES OF MIR-199A AS A THERAPEUTIC FOR CANCERThe invention relates to methods of measuring the level of expression of differentially expressed microRNAs (miRNAs), such as for example hsa-mir-199a, in a cancer cell as an indicator of the level of..USE OF THE COMBINATION OF PHY906 AND A TYROSINE KINASE INHIBITOR AS A CANCER TREATMENT REGIMENThis invention provides herbal compositions useful for increasing the therapeutic index of chemotherapeutic compounds. This invention also provides methods useful for improving the quality of life of ..ROCK INHIBITORS AND USES THEREOFThe subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are compounds that inh..METHODS AND COMPOSITIONS RELATED TO RIBOSWITCHES THAT CONTROL ALTERNATIVE SPLICING.Disclosed are methods and compositions related to riboswitches that control alternative splicing.AAV-MEDIATED DELIVERY OF DNA TO CELLS OF NERVOUS SYSTEMPROBLEM TO BE SOLVED: To provide a method of delivering a DNA exogenous to both an adeno-associated virus (AAV) and a target cell of the mammalian nervous system. ; SOLUTION: The method includes the s..A SNP MARKER OF BREAST AND OVARIAN CANCER RISKThe invention provides methods for predicting an increased risk or probability of developing breast or ovarian cancer in a patient based upon the patient's KRAS-Variant and BRCA status.TISSUE ENGINEERING OF LUNGThe present invention relates to compositions comprising a decellularized tissue. The present invention also provides an engineered three dimensional lung tissue exhibiting characteristics of a natura..NOVEL MARKERS FOR DETECTION OF COMPLICATIONS RESULTING FROM IN UTERO ENCOUNTERSDescribed herein are biomarkers, such as protein biomarkers, which are diagnostic of and predictive for complications that result from an in utero encounter, such as an infection by the fetus, that ca..COMPOSITIONS AND METHODS OF USE OF AN ONCOLYTIC VESICULAR STOMATITIS VIRUSOncolytic VSV viruses have been developed as a strategy for combating cancer. The present invention includes mutant VSV that have one or more mutations in the nucleic acid sequence encoding the viral ..DETECTION, ISOLATION AND USES OF RENALASE (MONOAMINE OXIDASE C)The present invention provides for the identification, isolation and uses of mammalian Monoamine Oxidase C (MAO-C), also known as renalase.Identification of cancer protein biomarkers using proteomic techniquesThe claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to discrimin..Semaphorin 7A Plays a Critical Role in TGF-Beta1-Induced Pulmonary Fibrosis and Alveolar DestructionThe present invention provides methods of treating a subject diagnosed with, or at risk for developing, pathogenic fibrosis, particularly pulmonary fibrosis. The method of the invention comprises admi..INHIBITORS OF RECEPTOR TYROSINE KINASES AND METHODS OF USE THEREOF.The present invention provides moieties that bind to an Ig-like domain, e.g., D4 or D5, of a human receptor tyrosine kinase, e.g., the human Kit RTK or the PDGFR RTK, or the D7 domain of a type V rece..METHODS AND COMPOSITIONS RELATED TO RIBOSWITCHES THAT CONTROL ALTERNATIVE SPLICING AND RNA PROCESSING.Disclosed are methods and compositions related to riboswitches that control alternative splicing.RIBOSWITCHES AND METHODS AND COMPOSITIONS FOR USE OF AND WITH RIBOSWITCHES.Riboswitches are targets for antibiotics and other small molecule therapies. Riboswitches and portions thereof can be used to regulate the expression or function of RNA molecules and other elements an..METHYLATION BIOMARKERS AND METHODS OF USEDisclosed are methods and compositions of assessing one or more statuses of a subject. Also disclosed are methods and compositions of identifying status biomarkers associated with a status of a subjec..IDENTIFICATION OF CANCER PROTEIN BIOMARKER USING PROTEOME TECHNIQUEPROBLEM TO BE SOLVED: To provide a testing method capable of being used in order to diagnose the cancer of an ovary in an initial stage or an advanced stage. ; SOLUTION: There are disclosed a method f..INSTRUMENTS, METHODS AND SYSTEMS FOR HARVESTING AND IMPLANTING CARTILAGE MATERIALSThe present disclosure provides instruments and systems for accessing and removing hyaline cartilage from desired donor sites. The present disclosure also provides instruments/systems for implantation..SINGLE NUCLEOTIDE POLYMORPHISMS IN BRCA1 AND CANCER RISKThe invention provides methods for identifying mutations, such as single nucleotide polymorphisms (SNPs), within breast and ovarian cancer associated genes that modify the binding efficacy of micro RN..JNK3 MODULATOR AND METHOD FOR USING THE SAMEPROBLEM TO BE SOLVED: To provide a method for screening a molecule and compound reducing the expression or activity of the c-Jun NH<SB>2</SB>terminal kinase (JNK) group of a MAP kinase. ; SOLUTION: Th..COMPOSITIONS AND METHODS FOR INHIBITING INFLAMMATION FROM AND REJECTION OF BIOMATERIALS AND OTHER METHODSThe present invention relates, inter alia, to methods and compositions for regulating the host response to biomaterials, including inhibiting inflammation from and rejection of biomaterials using sali..METHODS OF REGULATING RENALASE (MONOAMINE OXIDASE C)The present invention provides methods of using Monoamine Oxidase C (MAO-C), also known as renalase, as a therapeutic protein in its active and inactive forms. Administering inactive renalase protein ..Regulation of oncogenes by microRNAsNaturally occurring miRNAs that regulate human oncogenes and methods of use thereof are described. Suitable nucleic acids for use in the methods and compositions described herein include, but are not ..IMMUNIZATION TO REDUCE NEUROTOXICITY DURING TREATMENT WITH CYTOLYTIC VIRUSESMethods for protecting the brain and other tissues from virus- associated toxicity are provided. Patients are treated with a first immunizing virus prior to administration of a second, therapeutic cyt..TOLL-LIKE RECEPTOR 4 DEFICIENCY AND DOWNSTREAM EFFECTORS CAUSE PULMONARY EMPHYSEMAThe present invention provides compositions and methods for the detection, treatment, and prevention of emphysema/COPD. Compositions of the present invention comprise TLR4 activators, Nox3 inhibitors,..Targeting TGF-beta as a Therapy for Alzheimer's DiseaseThe invention includes compositions and methods for enhancing peripheral macrophage A[beta] phagocytosis activity. The invention includes inhibiting a component of TGF-[beta] signaling pathway in peri..Systems, Devices and Methods For Cartilage and Bone GraftingDisclosed are systems, methods, devices and products to identify suitable donor sites for harvesting bone-cartilage grafts and to implant such bone-cartilage grafts. In some embodiments, a method incl..SMALL MOLECULE INHIBITORS OF AUTOTAXIN AND METHODS OF USEAutotaxin (ATX) is a prometastatic enzyme initially isolated from the conditioned media of human melanoma cells that stimulates a myriad of biological activities including angiogenesis and the promoti..METHOD FOR THE DETERMINATION OF PHOSPHOLIPIDS IN AMNIOTIC FLUID SAMPLESThe present invention refers to a fast method for the determination of phospholipids in amniotic fluid samples by HPTLC (high performance thin layer chromatography). This innovative method presents hi..BRAIDED CORRUGATED TEXTILE VASCULAR PROSTHESIS AND PROCESS OF PRODUCING SAMEThe present invention relates to a braided corrugated vascular prosthesis with a textile structure consisting of at least two types of biocompatible fibres, of which one is absorbable by the human bod..COMPOSITIONS COMPRISING ANTIOXIDANT AND MITOPROTECTIVE FLAVONOIDS WITH NEUROPROTECTIVE PROPERTIESThe present invention discloses compositions comprising phenolic compounds present in plant extracts with therapeutic activity against neuronal excitotoxicity, oxidative stress and mitochondrial dysfu..ESTÉRASE THERMOPHILE DE THERMUS THERMOPHILUSThe invention relates to a thermophilic protein with esterase activity. Said protein, of the Thermus thermophilus organism, is expressed in recombinant yeasts and bacteria, in particular E.coli, K.lac..Biphasic calcium phosphate and method for obtaining same from fish bonesThe present invention relates to a biphasic calcium phosphate comprising between 5 and 40% by weight of beta-tricalcium phosphate; between 0.1 and 0.6% by weight of Mg; between 0.2 and 0.8% by weight ..USE OF A CASEIN-DERIVED PEPTIDE AND COMPOSITIONS THEREOF AS ANTIHYPERTENSIVEUse of a casein-derived peptide with antioxidant and ACE-inhibitory activity in vitro and antihypertensive activity in mammals, and compositions thereof. This peptide may be use as active ingredient i..Trangenic mice used as model for human pathologies originating from stem cellsTransgenic non-human mammals that reproduce the human pathology that is of stem cell origin, for example, chromosomal anomalies associated with chronic myeloid leukaemia, B-cell acute lymphoblastic le..CELL-CULTURE FLOW BIOREACTORCell-culture flow bioreactor that comprises an incubator (1), the receptacle (14) of which, to which access is gained via a hermetically sealed door (13), is defined by thermally insulating walls, and..LIPOSOMES COVERED WITH THE EXTRACELLULAR DOMAIN OF THE APO2L/TRAIL PROTEINThe invention relates to the field of biotechnology and medicine. The invention specifically relates to a compound comprising a liposome covered or decorated at least with the extracellular domain of ..SMART PACKAGING FOR DETECTING MICROORGANISMSThe present invention relates to novel smart packaging, designed using a novel material comprising a partially polar adsorbent solid base impregnated with a solution of vanillin, which allows the grow..VECTORS AND USES OF THE MBOUMAR TRANSPOSONThe invention relates to the recombinant production of a naturally active transposase of Messor bouvieri, transposon Mboumar-derived genetic constructions necessary for transgenesis and mutagenesis, a..NOVEL AMPEROMETRIC BIOSENSOR, PRODUCTION METHOD THEREFOR AND USE OF SAMEThe invention relates to a novel amperometric biosensor, the production method therefor and use of same. The invention is based on a combination of the laccase enzyme and sonogel-carbon materials. The..METHOD FOR ENHANCING THE EFFECTIVENESS OF BACTERIAL STRAINSA method for enhancing the pathogenicity of bacterial strains of the genus Bacillus, which comprises exposing the strain to temperatures below ambient temperature or other situations of stress, a comp..SINGLE-LABELLING AGENTS BASED ON VINYL SULPHONEThe invention relates to labelling agents containing a compound with a labelled molecule and a vinyl sulphone group. The invention also relates to the compounds, the method for obtaining same and the ..COMPOUND OF SILICA-VINYLSULPHONE, SYNTHESIS AND USES OF THE SAMECompound which comprises a medium of silica functionalized with vinylsulphone groups. In addition, the invention describes the method for production thereof and uses thereof as an immobilizer of biomo..POROUS BIOTIN CARRIER, AND ASSOCIATED PRODUCTION METHODS AND USESThe invention relates to a compound comprising biotin joined to a porous carrier by means of a linker containing the group 1, 2, 3-triazole. The invention also relates to the method for obtaining said..STRAIN CECT 7462 OF BACILLUS PUMILUS AND A METHOD FOR INCREASING THE ENTOMOPATHOGENIC EFFECTS THEREOFThe invention relates to a novel bacterial strain of Bacillus pumilus (CECT 7462 or B. pumilus TCC). Said strain can be treated with exposure to low temperatures in order to increase the entomopathoge..ANTIBODIES FOR TREATING CANCERThe invention relates to the use of an antibody or a fragment thereof, specific against substance P, for the manufacture of a medicament for therapeutic treatment of a cancer expressing NK1 receptor a..GENOME SEQUENCES OF PRIMERS AND A PROBE FOR THE QUANTIFICATION OF PORCINE ADENOVIRUSES (PAdV)The invention relates to a sensitive test for the detection of porcine adenoviruses in environmental samples, water and food. Specifically, the invention relates to a quantitative tool intended for th..CIS BICYCLIC COMPLEXES OF PLATINUM (II) HAVING ANTICANCER ACTIVITYThe invention relates to compounds having formula (I), wherein: the broken line represents a single or double bond; X is N, O, S, or -(CH2)n-; n is an integer between 1 and 3; R1 is a radical selected..NOVEL CHEMOTHERAPEUTIC AGENTS FOR CANCER TREATMENTThe invention relates to compounds having formula (15), shown below, in which R1 is H or I, R2 is a radical selected from (C1-C16)-alkyl, phenyl and benzyl, R3 is a (C2-C4)-alkyl group and the configu..NOVEL CHEMOTHERAPEUTIC AGENTS FOR TREATING CANCERThe compounds of formula (I) where: R1, R2, R3 and R4 are independently H, or a radical selected from hydroxyl; -OR; and -OCOR; where R is a radical selected from (C1-C4)-alkyl, phenyl, -(CH2)n-phenyl..CRANIAL IMPLANTAn Implant, such as a cranial implant (3), for attachment to a defect (2) in a bone structure (1) having an edge (4) is described. The implant comprises a direction of extension and a rim (5) extendin..USE OF GLYCOSAMINOGLYCAN FOR RESTORING GLYCOCALYXThe invention is directed to the use of glycosaminoglycans for restoring glycocalyx functions or preventing glycocalyx damage. The effectiveness of glycosaminoglycans is directed in all pathologies wh..In vitro method for predicting whether a compound is genotoxic in vivo.The invention is in the field of genomics and it provides an in vitro method for predicting whether a compound is genotoxic in vivo. It provides a method that employs the analysis of expression profil..HOMOGENEOUS, INTRINSIC RADIOPAQUE EMBOLIC PARTICLESThe invention is directed to embolic material comprising spherical, homogeneous and substantially non-porous radiopaque polymer particles based on at least one hydrophilic monomer and at least one rad..Method for determining the primary site of cupThe invention relates to a method for the classification of cancer using a specific multi-class tumor classifier comprising specific sets of genes for the interpretation of expression data obtained fr..PEPTIDE LIGANDS FOR TARGETING TO THE BLOOD-BRAIN BARRIERThe present invention relates to peptides comprising defined amino acid sequences, compositions comprising said peptides and a pharmaceutically acceptable substance, use of said peptides as a central ..HIGH THROUGHPUT METHOD AND SYSTEM FOR IN VIVO SCREENINGProvided is a method and system for screening chemical compounds or compositions, wherein replicating entities are introduced into the yolk of an (un)fertilized egg or embryo. The method may be extend..A BIOLOGICAL MICROFLUIDICS CHIP AND RELATED METHODSA biological microfluidics chip (100) comprising a substrate (102), a microfluidic inlet port (104) defining an opening in a surface of the substrate (102), and a microfluidic outlet port (106) defini..Novel mRNA splice variant of the doublecortin-like kinase gene and its use in cancer diagnosis and therapyMethods for treating neuroblastoma in a subject are provided. The methods include administering to the subject nucleic acid that is capable of causing a significant reduction of the amount of doubleco..A CELL CULTIVATION RECEPTACLE AND RELATED APPARATUSESA cell cultivation receptacle (10) comprises a recess layer (11) having formed therein a downwardly extending recess (12) defining an opening (13) on an upper side of the recess layer (11). The recess..METHODS FOR IMMOBILIZING MICROVESICLES, MEANS AND METHODS FOR DETECTING THEM, AND USES THEREOFThe invention provides a method for immobilizing microvesicles to a coated surface using a laminar flow. Further provided are a chip mould for the preparation of microfluidic chips suitable for use in..FUTURE CARDIAC EVENT BIOMARKERSThe present invention relates to the identification of chemokine biomarkers predictive of future acute coronary syndromes including unstable angina pectoris (UAP). The present invention also identifie..Novel Cross-Linkers For Obtaining Structure Information On Molecule ComplexesThe present invention describes a novel cross-linker, a method for preparing one or more cross-linked biomolecules, biomolecular complexes of two or more biomolecules, a method for preparing cross-lin..SYNUCLEINOPATHIESPresent inventions demonstrates that NHE-1 inhibiting carbonylguanidine derivatives inhibit a-synuclein toxicity. Such compounds can be used in the treatment or prevention of synucleinopathies, such a..MUTANT AOX 1 PROMOTERSA mutant Pichia pastoris alcohol oxidase 1 (AOXl) promoter of the wild type Pichia pastoris AOXl promoter (SEQ ID No. 1) comprising at least one mutation selected from the group consisting of : a) a t..Biomarker for osteoarthritis and/or other ageing-related diseases, and use thereofThe invention relates to the identification of a biomarker whose abundance in bodily fluids is changed in subjects with osteoarthritis and/or other ageing-related diseases. The biomarker has applicati..METHOD FOR THE PRODUCTION OF RECOMBINANT PROTEINS BY GREEN MICROALGAEThe present invention relates to a method for the production of recombinant proteins by algal cells, which are fresh water unicellular green microalgae belonging to the order of Sphaeropleales. The pr..BIOMARKER FOR OSTEOARTHRITIS AND/OR OTHER AGEING-RELATED DISEASES, AND USE THEREOF.The invention relates to the identification of abiomarker whose abundance in biologicalsamplesis changed in subjects with osteoarthritis and/or other ageing-related diseases. Thebiomarker hasapplicati..APTAMERS DIRECTED AGAINST THE MATRIX PROTEIN-1 OF TYPE A INFLUENZA VIRUSES AND USES THEREOFThe present invention relates to nucleic acids that bind specifically to the matrix protein- 1 of type A influenza viruses and uses thereof for detecting such viruses in a sample of interest. More par..HIV-REV-MULTIMERIZATION INHIBITING NANOBODIESThe present invention relates to an anti-HIV-Rev antibody. More specifically, the invention relates to a nanobody that is able to inhibit the multimerization of the Revprotein, and by this, it inhibit..ENHANCING THE T-CELLS STIMULATORY CAPACITY OF HUMAN ANTIGEN PRESENTING CELLS AND THEIR USE IN VACCINATIONWith the current invention, we provide new methods of enhancing the T-cell stimulatory capacity of human dendritic cells (DCs) and their use in cancer vaccination. The method comprises the introductio..AQUEOUS COACERVATE COMPOSITION COMPRISING POORLY WATER-SOLUBLE BIOLOGICALLY-ACTIVE AGENTSThis invention relates to an aqueous gelatin-free, egg portion-free, two-phase coacervate composition comprising a coacervate phase and an equilibrium water phase, comprising, per 100 parts by weight,..PLANT GROWTH PROMOTING PROTEIN COMPLEXThe present invention relates to a plant growth promoting protein complex. More specifically, the invention relates to the use of specific proteins from the Anaphase Promoting Complex/Cyclosome for in..INHIBITORS OF F18+ E COLI BINDINGThe present invention relates to blood group A/B/H determinant on Type 1 Core glycosphingolipids chains as recognition point for the FedF protein of F18-fimbriated Enterotoxigenic and verotoxinogenic ..INCORPORATION OF THERMO-RESISTANT AND/OR PRESSURE-RESISTANT ORGANISMS IN MATERIALSThe present application relates to methods for producing materials having viable micro-organisms incorporated therein. More particularly, the materials are produced under high temperature and/or high ..SUBSTITUTED 7-AZABICYCLO[2.2.1]HEPTYL DERIVATIVES USEFUL FOR MAKING PHARMACEUTICAL COMPOSITIONSThis invention provides 1-substituted-7-azabicyclo[2.2.1]heptyl derivatives, intermediates and methods for producing them, which are therapeutic agents useful for the prevention and treatment of centr..CATIONIC LIPOSOMES FOR THE DELIVERY OF HIGH MOLECULAR WEIGHT COMPOUNDSThe present invention relates to a specific type of liposomes, denominated as SECosomes, made from a cationic lipid such as 1, 2-dioleoyl-3-trimethylammonium propane (DOTAP), a surfactant such as sodi..METHODS AND COMPOSITIONS IN THE TREATMENT OF CORONAVIRUSESThe invention relates generally to the field of virology, and relates to the identification and characterization of the targets involved in the evasion strategy of viruses and to the use thereof in me..LIVER-SPECIFIC NUCLEIC ACID REGULATORY ELEMENTS AND METHODS AND USE THEREOFThe present invention relates to nucleic acid regulatory elements that are able to enhance liver-specific expression of genes, methods employing these regulatory elements and uses of these elements. E..METHODS AND SYSTEMS FOR CHANNEL SELECTIONA system and method are described for estimating a property of a neural or cardial source using inverse problem solving including a forward numerical model. The system comprises a selection means for ..METHODS FOR PRODUCING SUBSTANTIALLY HOMOGENEOUS HYBRID OR COMPLEX N-GLYCANS IN METHYLOTROPHIC YEASTSThe present invention provides methods for effectively and efficiently converting methylotrophic yeast's heterogeneous high mannose-type N-glycosylation to mammalian-type N-glycosylation by disruption..CELLS PRODUCING GLYCOPROTEINS HAVING ALTERED GLYCOSYLATION PATTERNS AND METHODS AND USE THEREOFThe present application relates to the field of glyco-engineering, more specifically to eukaryotic cells wherein both an endoglucosaminidase and a glycoprotein are present. These cells can be used to ..MINICHROMOSOME MAINTENANCE COMPLEX INTERACTING PROTEIN INVOLVED IN CANCERThe present invention relates to a protein that is interacting with the minichromosome maintenance complex in eukaryotes. More specifically, the invention relates to the use of a protein, interacting ..A PROTEOLYTIC PRODUCT OF HISTONE H2A AS A MARKER FOR CANCERThe present invention relates to proteolytic products of histone H2A. In particular, the present invention discloses a peptide having the amino acid sequence VTIAQGGVLPNIQAV which can be used to deter..NOVEL IMMUNOTHERAPY STRATEGYThe present invention relates to polyacetal-carboxylic acids, more in particular chlorite-oxidized oxyamylose (COAM) for use as a medicine, more in particular for the treatment or prevention of cancer..ACTIVATORS OF THE AUTOPHAGIC PATHWAYBy present invention it has been clearly demonstrated that polyamine compounds of the groups consisting of putrescine, spermine, spermidine, cholesteryl spermine, spermidine trihydrochloride, spermidi..HSC SELF-RENEWALThe invention is related to methods for culturing stem cells, more particularly hematopoietic stem cells (HSC). The invention relates to methods for HSC expansion and the use of factors to increase th..FUNCTIONAL LAYERS OF BIOMOLECULES AND LIVING CELLS, AND A NOVEL SYSTEM TO PRODUCE SUCHThe present invention concerns a new process for depositing a thick compact layer of biomolecules for instance such a layer with thickness in the [mu]m scale and, for depositing a thick compact layer ..USE OF NUCLEOSIDE ANALOGS AS ANTI-KOI HERPES VIRUS MOLECULESThe present invention relates to the use of substituted or unsubstituted bis(hydroxymethyl)-cycloprop-1'-ylmethyl nucleobase derivatives as active agents for the treatment or prevention of Koi Herpes ..INSERTION SEQUENCE DETECTION PROTOCOLThe present invention relates to a novel microarray-based methodology, referred to as 'Sliding Window Hybridization' (SWH), for reliable and convenient detection of short nucleic acid sequences in gen..HEPATOCELLULAR CARCINOMAPresent invention concerns a kit and an in vitro method, for evaluating a biological stage of an HCC tumour in an individual, based on a sample from the individual, comprising: deriving from the sampl..NOVEL PHOSPHATE MODIFIED NUCLEOSIDES USEFUL AS SUBSTRATES FOR POLYMERASES AND AS ANTIVIRAL ANGENTSThis invention provides phosphate-modified nucleosides represented by the structural formula: wherein W is O or S, and wherein B, R1; R3 and R2. are s defined herein. These compounds are useful as sub..INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASESThis invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neur..STEM CELL AGGREGATES AND METHODS FOR MAKING AND USINGThe invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differen..NEW ENDOLYSIN OBPGPLYSThe present invention relates to a polypeptide with an amino acid sequence according to SEQ ID NO: 1 and fragments or derivatives thereof. The present invention further relates to fusion proteins comp..ANTIMICROBIAL AGENTSThe present invention relates to endolysin variants comprising an endolysin to which a peptide stretch with membrane or LPS disrupting activity is fused. Moreover, the present invention relates to nuc..METHOD FOR INACTIVATING AT LEAST ONE PATHOGEN IN HUMAN BLOOD PLASMA SAMPLEThe present invention relates to a method for inactivating at least one pathogen of a human blood plasma sample, including: adiabatically compressing said sample, the temperature of said plasma being,..ROCAGLAOL DERIVATIVES AS CARDIOPROTECTANT AGENTS AND AS ANTINEOPLASTIC AGENTSThe present invention discloses new rocaglaol derivatives and the use of rocaglaol derivatives to prevent or to limit the cardiotoxicity of an antineoplastic agent, in particular to prevent or to limi..MECHANICALLY RESPONSIVE SUPPORTED POLYELECTROLYTE MULTILAYER FILMSThe invention concerns a mechanically responsive supported polyelectrolyte multilayer film, comprising: - an elastic substrate, on which are alternately coated: - at least one exponentially growing fi..BIOLOGICALLY ACTIVE COMPOSITIONS, METHODS FOR PRODUCING THE SAME AND BIOLOGICAL APPLICATIONSUse of a product from plants comprising extracts, fractions and/or molecules as G-protein coupled receptor (TGR5) specific agonist, having minimum effective concentration (EC50) of greater/equal to TG..TOCOPHEROL DERIVATIVES WITH A LONG HYDROXYLATED CHAIN, WHICH CAN BE USED AS NEUROTROPHICSLa présente invention a pour objet tout composé isolé ou synthétique, et en particulier les composés de formule (I), provoquant la différentiation de cellules précurseurs d'oligodendrocytes, ai..MONOCLONAL ANTI-CLAUDIN 1 ANTIBODIES FOR THE INHIBITION OF HEPATITIS C VIRUS INFECTIONThe present invention provides monoclonal antibodies that specifically bind to the extracellular domain of human Claudin-1 on the cell surface, thereby inhibiting HCV entry into susceptible cells and ..THIN-LAYER PHOTOBIOREACTOR WITH HIGH VOLUME PRODUCTIVITYThe invention relates to a photobioreactor (1) for the culture of cells, comprising a runoff substrate (2) having a surface inclined at an average slope along a direction of inclination (I-I) on which..NOVEL MELANOMA ANTIGEN PEPTIDE AND USES THEREOFThe present invention relates to novel melanoma antigen peptides and specific T lymphocytes directed to said peptides and the use thereof for treating melanoma.Method for making biochipsA method for immobilizing biological polymers such as DNA or proteins, on a solid support, by ionocovalent bond, for making biochips, and the resulting chips obtained by the method.CELLULAR DIFFERENTIATION PROCESS AND ITS USE FOR BLOOD VESSEL BUILD-UPThe present invention relates to the use of specific oxygen concentrations for implementing a process of differenti-ation of stem, provided that said stem cells are not humanembryonic stemcells, and s..MUTATED HYPERTHERMOPHILIC PHOSPHOTRIESTERASES AND USES THEREOFA subject of the present invention is mutated hyperthermophilic phosphotriesterases (PTEs) possessing a lactonase activity, and their uses as bioscavengers within the context of the decontamination of..THERAPEUTIC PEPTIDES AND METHODA polypeptide comprising one or more sequences derived from CDR2 or CDR3 of a TREM-1 protein, characterised by the ability to treat, ameliorate, or lessen the symptoms of sepsis, septic shock or sepsi..Peptide useful as an antimicrobial agent has a defined sequence of 14 amino acidsAntimicrobial peptide (I) has a defined sequence of 14 amino acids. Peptide (I) with antimicrobial activity has the amino acid sequence Lys Lys Lys Lys Pro Leu Phe Gly Leu Phe Phe Gly Leu Phe. INDEPEN..C4D/C4B STANDARD FOR QUANTITATIVE FLOW CYTOMETRY OF HUMORAL TRANSPLANT REJECTIONThe invention concerns an internal standard used to quantitative analysis of the risk of humoral (i.e. vascular) transplant rejection. The internal standard consists of a stable composition of the C4d..USE OF CENTRIFUGAL PARTITION CHROMATOGRAPHY FOR PURIFYING GALANTHAMINEThe invention concerns the use of centrifugal partition chromatography in displacement mode for implementing a process for purifying galanthamine or its derivatives, from a starting composition, conta..METHODS AND SYSTEMS FOR EXPANDING AC133+ CELLS AND DIRECTING DIFFERENTIATIONThe invention provides, among other things, methods and systems for expanding CDl 33+ cells. The invention further provides methods and systems for increasing the blood flow to an ischemic tissue in a..METHOD OF IDENTIFYING MICRO-ORGANISMS AND THEIR SPECIES IN BLOOD CULTUREThe invention relates to a method of identifying micro-organisms and their species in a blood culture by mass-spectrometry and to a device for implementing such a method.4S-IOTA-CARRAGEENAN SULFATASE AND USE THEREOF TO OBTAIN ALPHA-CARRAGEENANThe present invention relates to 4S-iota-carrageenan sulfatase and to the use thereof for partially or totally converting the iota-carrageenan into iota-/alpha-carrageenan or alpha-carrageenan. The in..METHOD FOR DETECTING A CIRCULARIZED DNA, AND USE OF SAID METHOD FOR DETECTING MUTATIONSThe present invention relates to a method for detecting a circularized single-stranded DNA by means of the isothermal hyperbranched rolling circle amplification technique, in which the primers used co..LEPTIN ANTAGONISTSThe invention relates to synthetic leptin antagonists in which at least two amino acid residues of the sequence LDFI/S of the hydrophobic binding site at positions 39-42 of a leptin polypeptide sequen..NUCLEIC ACID MOLECULES AND METHODS FOR EXCHANGING EXON(S) BY TRANSSPLICINGThe present invention provides methods and compositions for generating novel nucleic acid molecules through targeted spliceosome mediated simple or double trans-splicing. The compositions of the inven..A STIMULATABLE ASYMMETRICAL POLYMERSOMEThe invention relates to a polymer vesicle with an asymmetrical unilamellar membrane, said membrane being constituted by two distinct layers, a layer (A) and a layer (B), said layers comprising respec..NON-AUXOTROPHIC SELECTION MARKERA non-auxotrophic selection marker located in a gene cluster encoding a metabolite for an organism, such as a fungus, lacking said marker is provided. The selection marker gene can be used to detect a..METHOD FOR DETECTING PHOSPHOPANTETHEINYL TRANSFERASE ACTIVITYThe invention provides a method for detecting 4 -phosphopantetheinyl transferase (4 PPTase) activity, the method comprising the steps of: (a) immobilising a carrier protein domain or a functional frag..A METHOD FOR SCREENING COMPOUNDSA method of screening compounds or molecules comprising the steps of: translating a sequence encoding the amino acid sequence comprising SEQ ID No. 29 in a translation system in the presence of a test..Modulation of tissue fatty acid composition of a host by human gut bacteriaThe current invention provides use of a CLA - producing bacterium for the in vivo conversion in the gut of polyunsaturated fatty acids to CLA. The CLA-producing bacterium is selected from one or more ..ORALLY ADMINISTERED BACTERIA AS VEHICLES FOR SYSTEMIC DELIVERY OF AGENTSThe current invention relates to the use of a bacterial species in the preparation of a composition adapted for oral administration for the delivery of an agent to a site in the body. The site in the ..METHOD FOR OPENING TIGHT JUNCTIONSThe present invention is directed to a method and use of RNA interference (RNAi) for the transient, reversible and controlled opening of the tight junctions of the blood brain barrier and/or the blood..CYTOKINES AS PROGNOSTIC MARKERS OF RESPIRATORY-TRACT INFECTION FOLLOWING MAJOR SURGERYThe invention relates to the use of a certain subset of cytokine markers as prognostic variables of infection status in an individual, and especially as prognostic markers of a patients developing sev..A METHOD OF ESTIMATING SEPSIS RISK IN AN INDIVIDUAL WITH INFECTIONA method of estimating sepsis risk in an individual with infection comprises a step of assaying a biological sample from the individual for an IL-2 or IL-7 mRNA value, and correlating the mRNA value w..RNAI IN BUDDING YEASTThe invention provides budding yeast that have a functional RNAi pathway. The invention provides RNAi pathway polypeptides derived from budding yeast that have an endogenous RNAi pathway. In some embo..METHOD FOR PRODUCING POLYHYDROXYALKANOATEA method for producing polyhydroxyalkanoate (PHA), comprising (i) culturing in a culture medium comprising terephthalic acid and/or a salt thereof and/or an ester thereof one or more bacterial strains..PSEUDOMONAS PUTIDA STYRENE MONOOXYGENASE VARIANTSThe present invention provides isolated polynucleotides derived from Pseudomonas putida, and encoding polypeptides having styrene monooxygenase activity. The polynucleotides of the present invention a..A METHOD FOR PREDICTING ATHLETIC PERFORMANCE POTENTIALA method and assay for predicting athletic performance potential of a subject, such as a thoroughbred race horse, comprising the steps of assaying a biological sample from a subject for the presence o..A METHOD OF IMMOBILISING BIOLOGICAL MOLECULES TO A SUPPORT AND PRODUCTS THEREOFA support comprising a substrate, wherein a surface of the substrate comprises functional amino or aldehyde groups, for the covalent binding of a biomolecule. The biomolecule may be a protein such as ..ANTI-SIALIC ACID ANTIBODY MOLECULESA method of generating and isolating a recombinant high affinity anti-sialic acid antibody molecule comprises the steps of immunising a host with an immunogen comprising a conjugate of sialic acid and..A MULTI-WELL PLATE FOR BIOLOGICAL ASSAYSA multi-well plate (1) for a biological assay comprising a plate frame (4) attached to a support substrate (7) through a gasket (5) wherein the plate frame (4) defines side walls for a plurality of we..ISOTHERMAL AMPLIFICATION METHOD FOR DETECTION OF NUCLEIC ACID MUTATIONA method is provided for detection of a nucleic acid region in a biological sample, by use of an isothermal amplification reaction, such as loop-mediated isothermal amplification (LAMP). In particular..CRYSTAL STRUCTURE OF A PLASMA MEMBRANE PROTON PUMPThe present invention relates to a crystal structure of a plasma membrane proton pump type ATPase. The invention further describes method for identification of modulators of ATPases as well as uses of..SUBMERGED PERFUSION BIOREACTORThe present invention discloses a device for biological purposes such as cell culturing, enzymatic reactions or filtering of fluid, which comprises a body having a first and a second surface, and wher..COMPOSITIONS AND METHODS FOR TREATMENT AND DIAGNOSIS OF SYNUCLEINOPATHIESA method of treating a neurodegenerative disorder is provided, wherein compound, which inhibits or down-regulates the expression of a gene selected from the group consisting of Gadd45a, Gadd45b, Gadd4..TFF3 HYPOMETHYLATION AS A NOVEL BIOMARKER FOR PROSTATE CANCERThe present invention relates to a TFF3 gene as a marker of prostate cancer. The present invention thus relates to methods for diagnosing prostate cancer or predicting or prognosticating the disease o..SELECTIVE EXOSITE INHIBITION OF PAPP-A ACTIVITY AGAINST IGFBP-4.The present invention relates in one embodiment to PAPP-A exosite(s) interactors such as antibodies which bind to a region comprising LNR3 of PAPP-A and efficiently inhibit proteolysis of IGFBP-4, but..BIOCOMPATIBLE MATERIALS FOR MAMMALIAN STEM CELL GROWTH AND DIFFERENTIATIONA biocompatible material, wherein at least a part of a surface of the biocompatible material is characterized by a micro or nano-meter scale topographical structure comprising a plurality of features ..MODIFIED PEPTIDES AS POTENT INHIBITORS OF THE PSD-95/NMDA RECEPTOR INTERACTIONThe present invention is directed to the provision of small molecule inhibitors of the PSD-95/NMDA receptor interaction, employing an undecapeptide corresponding to the C-terminal of the NMDA as a tem..USE OF NOVEL BIOMARKERS FOR DETECTION OF TESTICULAR CARCINOMA IN SITU AND DERIVED CANCERS IN HUMAN SAMPLESThe present invention relates to methods and kits for identification of testicular carcinoma in situ (CIS), gonadoblastoma (a CIS-like pre-cancerous lesion found in dysgenetic gonads) and CIS-derived ..DNA-BASED METHODS FOR CLONE-SPECIFIC IDENTIFICATION OF STAPHYLOCOCCUS AUREUSMRSA CC398 is a clone of S. aureus that has recently emerged in pigs and other domestic animals worldwide. As any other MRSA, the clone displays high levels of antibiotic resistance and poses a seriou..BIOSYNTHETIC ENGINEERING OF GLUCOSINOLATESThe invention provides methods and materials, such as newly characterised genes, and novel processes, for converting a host from a phenotype whereby the host is unable to carry out glucosinolate (GSL)..Porcine polymorphisms and methods for detecting themIdentification of a pig as resistant or non-resistant to enterotoxigenic E. Coli (ETEC). Particularly, there is provided methods, probes and DNA molecules involved in identifying a pig as resistant or..A NUCLEOTIDE VACCINEThe present invention relates to a vaccine comprising a nucleic acid construct such as a DNA construct especially a nucleic acid construct comprising sequences encoding invariant chain operatively lin..Thermostable DNA polymerase of the archaeal ampullavirus ABV and its applicationsThe present invention is directed to the thermostable DNA polymerase protein of the archaeal ampullavirus ABV (Acidianus Bottle-shaped virus) and the nucleic acid encoding said DNA polymerase. The inv..FLAVIN MONOOXYGENASES AND TRANSCRIPTION FACTORS INVOLVED IN GLUCOSINOLATE BIOSYNTHESISThe invention provides methods and materials relating generally to plant derived flavin-containing monooxygenases (FMOs) capable of catalysing oxidation of a thio- to a sulphinyl- group during glucosi..ANALYSING BREATH SAMPLES FOR VOLATILE ORGANIC COMPOUNDThe invention describes the use of a biomarker pentylfuran to detect bacterial and/or fungal pathogens. Pentylfuran is released from certain pathogens and detected in the headspace gas of an in vitro ..NITRIC OXIDE DONORSThe invention relates to novel NO donors which are targeted to the mitochondria. The NO donor compounds of the invention allow NO to be selectively provided to the mitochondria.DETECTION OF VOLATILE COMPOUNDS AS MARKERS FOR MYCOBACTERIA TUBERCULOSISThe invention relates to the use of biomarkers for identifying bacterial pathogens. In particular, the invention relates to the detection and identification of certain compounds as markers for mycobac..ANTI-CANCER COMPOSITIONS CONTAINING A SHARK MEAT EXTRACT AND A MUSHROOM EXTRACTThe invention relates to anti-cancer compositions comprising synergistically effective amounts of an extract of shark meat and an extract of a mushroom, in particular, compositions containing a shark ..FUSION POLYPEPTIDES AND USES THEREOFThe invention relates to fusion polypeptides comprising a polynucleotide-binding domain, such as a DNA-binding domain, and a ligase domain, such as a DNA ligase domain, methods for the production of s..Immunogenic polypeptide isolated from mycobacterium avium subspecies paratuberculosis and uses thereofThe present invention relates to an immunogenic polypeptide isolated from Mycobacterium avium subspecies paratuberculosis and variants of the polypeptide. The polypeptide and variants may be used in v..MEMBRANE PROTEIN EXPRESSION SYSTEM AND ITS APPLICATION IN DRUG SCREENINGPROBLEM TO BE SOLVED: To provide a convenient in vitro membrane protein expression system using an inhibitor of drug efflux pump proteins and heterologous cells for testing other drug resistance-relat..Peptoid compoundsThe invention relates to new peptoid compounds of formula (I), as well as their use in the treatment of bacterial infections, such as those caused by vancomycin resistant microorganisms, and to compos..CRYSTAL STRUCTURE OF A BACTERIAL ENZYME AND USES THEREOFThe present invention is predicated, in part, on the determination of the crystal structure of Staphylococcus aureus biotin protein ligase. The present invention provides, among other things, the crys..DUAL FUNCTIONING IONIC LIQUIDS AND SALTS THEREOFDisclosed herein are ionic liquid compositions comprising active pharmaceutical, biological, and nutritional compounds, and methods of use. Further disclosed are compositions of matter including liqui..A NEURAL ANALYSIS SYSTEMA neural analysis system, including: a neural event extractor for generating Sp/Ap curve data and field potential data for background and initial response segments obtained from a person; a correlator..NAVIGABLE SYSTEM FOR CATHETER BASED ENDOVASCULAR NEUROSURGERYA navigable system for catheter based endovascular neurosurgery including: a micro-motor (3) including a piezoelectric actuator (5) mounted to a free end of a guidewire or micro-catheter (2), the piez..TESTING DEVICE FOR IDENTIFYING ANTIGENS AND ANTIBODIES IN BIOFLUIDSA testing device for identifying an antigen or antibody within a biofluid sample including: a substrate having a hydrophilic surface thereon; the surface including a collection zone, and at least one ..Anti-angiogenic agents and methods of their useThe present invention relates to the use of sFRP-4 and functional variants thereof as anti-angiogenic agents. It relates to methods of treatment and screening methods using sFRP-4 and functional varia..A COLLAGEN SCAFFOLD FOR CELL GROWTH AND A METHOD FOR PRODUCING SAMEA bioscaffold and method of manufacture is described. The bioscaffold comprised greater than 80% type I collagen fibers or bundles having a knitted structure providing tensile load strength. The metho..METHOD FOR PREDICTING ENGRAFTMENT POTENTIALThe invention relates to methods for the identification of proliferating stem cells in products for transplantation, and uses thereof. More specifically, the invention relates to methods for predictin..CLASSIFICATION OF BIOLOGICAL SAMPLES USING SPECTROSCOPIC ANALYSISA method and system is described for rapidly classifying a sample of a biological fluid, comprising obtaining a spectrum of the biological fluid in response to excitation of the sample in a specified ..INJECTABLE BIOMATERIALSInjectable biomaterial compositions formed from tropoelastin for tissue repair and restoration. The compositions include a coalescence-controlling agent in the form of a polysaccharide or polysacchari..THERAPEUTIC AND DIAGNOSTIC MOLECULESThe present invention relates to methods for modulating angiogenesis, comprising administering to a subject, or cells or tissue derived therefrom: (i) one or more miRNA, or precursors or variants ther..A NOVEL REGULATOR OF CELLULAR SENESCENCEProvided herein are methods for regulating whether a cell undergoes apoptosis or senescence, comprising modulating the level of expression an/or activity of SENEX in the cell, wherein increasing the e..BIOCOMPATIBLE MATERIAL AND USES THEREOFThe present invention relates to a biocompatible ceramic material comprising Sr, Mg or Ba doped Hardystonite (Ca2ZnSi2O7 ), and a method for its synthetic preparation. The present invention also relat..ENHANCEMENT OF MICROBIAL COLONIZATION OF THE GASTROINTESTINAL TRACTPROBLEM TO BE SOLVED: To provide a composition not only transporting probiotic microorganism to the large bowel but also containing a medium functioning to promote the growth of microorganisms when ar..Method of screening multiply transformed cells using bicistronic expression of fluorescent proteinsA method of screening multiply transformed/transfected cells to identify those cells expressing at least two peptides or proteins of interest. The method comprising: 1. Simultaneously or sequentially ..A METHOD OF TRANSFECTION AND COMPOSITIONS THEREFORThe present invention relates to the targeted delivery of molecules to cells expressing toll-like receptors (TLRs). Aspects of the invention provide compounds comprising a positively charged group lin..AN ASSAY FOR MONITORING A NEUROLOGICAL CONDITIONThe present invention relates generally to biomarkers of neurological conditions including monitoring disease progression and the clinical severity of symptoms. More particularly, the present inventio..POLYSACCHARIDE SYNTHASES (H)The present invention relates generally to polysaccharide synthases. More particularly, the present invention relates to (1,3; 1,4)-ss- D-glucan synthases. The present invention provides, among other ..IMMUNOMODULATING COMPOSITIONS COMPRISING INTERLEUKIN 13 INHIBITORS AND USES THEREFORThis invention relates generally to compositions and methods for modulating immune responses. More particularly, the present invention relates to the co-expression, co-location or co-presentation on h..UDP-GALACTOPYRANOSE MUTASE FROM HAEMONCHUS CONTORTUS, AND RNAI AGENTS THAT INHIBIT ITThe invention relates to the cloning of the Haemonchus contortus UDP-galactopyranose mutase gene, which is homologous to the C elegans glf-1. Also disclosed is the use of RNAi agents targeting this en..INHIBITION OF DEGRADATION OF EXTRACELLULAR MATRIXThis application realtes to a method of inhibiting the degradation of an extracellular matrix associated with islet beta cells, said method comprising contacting said extracellular matrix with an effe..Generation of cartilage using magnetizable particlesThere is described a method of magnetically manipulating a cell in vivo which comprises the association of a magnetizable particle with a cell. More particularly, there is described a method of magnet..Whitened exine shellsA whitened exine shell haying a degree of whiteness (L*) of greater than 65 measured under D 65 illumination. The shell can be used as a delivery vehicle for an active substance, or as an antioxidant...Method of obtaining exine shells of narurally occurring sporesA method for obtaining exine shells of naturally occurring spores directly from harvested biological material, the method comprising the steps of (a) treating the material with a mixture of an acid an..Culture of Crypthecodinium cohnii and microorganisms derived therefromCrypthecodinium cohnii, or microorganisms derived from Crypthecodinium cohnii, are grown in a culture medium including propionic acid. The propionic acid increases the production of one or more of dry..MICROTRENCH AND TUMOUR PROLIFERATION ASSAYThere is provided a cell culture microtrench being defined on or in a surface of a substrate, wherein the ratio of the width of the microtrench to the maximum length of the short axis of a cell type o..PEPTIDES DERIVED FROM THE NEURAL-RESTRICTIVE SILENCER FACTOR REST AND USE THEREOFThe invention relates to peptides derived from neural-restrictive silencer factor which modulate expression of CD59 and thus affect antibody-mediated complement cytotoxicity in tumours.VIBRATING MICROPLATE BIOSENSING FOR CHARACTERISING PROPERTIES OF BEHAVIOUR OF BIOLOGICAL CELLSThere is described a method of characterising a property or behaviour of at least one biological cell. The method comprises the steps of: providing a microplate; submerging at least one surface of the..ACETIC ACID AND A BUFFERThe present invention relates to a composition comprising : a) 0.01-20% wt/wt acetic acid and b) a physiologically tolerable buffer capable of maintaining acetic acid at a pH in the range of 2-7; and ..COMPOSITIONS AND METHODS OF USE OF STANDARDIZED MIXTURESThe present invention is directed to methods and compositions for evaluating nucleic acids, methods of preparing such compositions, and applications and business methods employing such compositions an..METHODS AND COMPOSITIONS FOR IDENTIFYING BIOMARKERS USEFUL IN CHARACTERIZING BIOLOGICAL STATESThe present invention relates to methods, compositions, and kits for identifying biomarkers useful in characterizing biological states. In particular, the invention relates to methods and compositions..BIOMARKERDescribed are gastrointestinal cancer specific biomarkers comprising the nucleic acid sequence of the Engrailed-2 (EN2) gene or the amino acid sequence of the encoded EN2 protein. Also described are u..BIOMARKER ER2 FOR GYNAECOLOGICAL CANCERDescribed are gynaecological cancer specific biomarkers comprising the nucleic acid sequence of the Engrailed-2 (EN2) gene or the amino acid sequence of the encoded EN2 protein. Also described are use..PEPTIDIC CONJUGATES COMPRISING POLYHISTIDINE SEQUENCE AND FREE CYSTEINE AND THEIR USES IN IMAGINGBioconjugates for use in imaging are disclosed include a linker sequence fused to a polypeptide capable of binding a target in a biological system. The linker sequence is designed so that it is capabl..MICELLAR COMPOSITIONS FOR USE IN BIOLOGICAL APPLICATIONSThis invention relates to a composition comprising a micelle for use in biological applications, the micelle comprising: a substantially water-insoluble conjugated polymer which exhibits luminescence ..ELECTRICALLY CONDUCTIVE DNA POLYMER HYBRID AND METHOD OF MANUFACTUREAn electrically conductive DNA polymer hybrid, in particular a DNA polymer hybrid nanowire comprising a polymer having a first functional group that is complementary to a second functional group on a ..MARKERS OF OOCYTE VIABILITYThere is disclosed a method of determining the potential of individual oocyte to develop into a viable embryo, which method comprises establishing the concentration of any one or more of the markers i..SCAFFOLDThe present invention provides a polymeric scaffold containing an antibacterial photoactive drug and optionally comprising seeded cells such as stem cells. The invention also includes methods of using..AN AGENT FOR TRANSPORTING NUCLEAR SPIN ORDER AND FOR MAGNETIC RESONANCE IMAGINGAn agent for magnetic resonance studies, the agent comprising hyperpolarized 15N labelled N2O in solution or liquid 15N-N2O.TISSUE ANALYSISThe present invention provides a method of tissue analysis, disease modelling or drug development comprising the steps of providing a tissue sample comprising cells of at least two different cell type..A METHOD OF DETECTING A SUBJECT AT RISK OF, OR HAVING, AN INDICATION ASSOCIATED WITH CORONARY ARTERY DISEASEThere are disclosed methods and biomarkers for detecting an indication associated with, or risk of, coronary artery disease In an embodiment, a method includes obtaining a sample including bone marrow..FLUIDICS APPARATUS AND FLUIPICS SUBSTRATEA fluidics apparatus is disclosed for manipulation of at least one fluid sample, typically in the form of a droplet. The apparatus has a substrate surface with a sample manipulation zone for location ..METHODS CONCERNING PPAR DELTA AND ANTAGONISTS THEREOFNon-human animals which overexpress PPARd or which express transgenic PPARd are useful as models for inflammatory skin conditions such as psoriasis. Test substances can be screened to assess their sui..APPARATUS AND METHOD FOR THE DETECTION OF CELLSAn apparatus and method for in-vivo detection of magnetically labelled biological molecules or cells, located in a flowing medium in a human or animal body such as the blood stream (13). The apparatus..BIOMOLECULE BINDING LIGANDSThe invention provides biomolecule binding ligands, collections of biomolecule binding ligands, and their use in the purification of biological mixtures and in the identification of ligands having an ..SUPRAMOLECULAR HANDCUFFS IN POLYMERIC ARCHITECTUREThis invention pertains generally to supramolecular polymers comprising a polymeric molecule linked to a first CB[8] guest molecule and an attachment compound linked to a second CB[8] guest molecule, ..Composite biomaterial formed by cooling a fluid composition on a porous solid and removing solidified crystals of the liquid carrierA process for the preparation of a composite biomaterial comprising providing a first solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthe..PROTEIN AGGREGATION PREDICTION SYSTEMSWe describe methods for identifying aggregation-prone regions in structured-that is folded-proteins. Embodiments of the method use a local propensity for aggregation (Ai) at an amino acid position, th..AGENTS FOR DETECTING AND IMAGING CELL DEATHThis invention relates to molecular imaging agents comprising an S78C mutant synaptotagmin I C2A domain. These agents may be useful in detecting or assessing cell death in vitro and in vivo, for examp..TRX1 AntibodiesHumanised antibodies, TRX1 include modified constant regions and light and heavy chain framework of human antibody and CDR regions derived from a mouse monoclonal antibody. TRX1 binds to an epitope of..Galvanic micro-pump e.g. for generating small micro-flows in bio-technology, uses partitioning wall with high resistance for convective flow of electrolyte fluidA galvanic micro pump has two electrodes (1,2) and at least one working chamber containing an electro-liquid and with each working chamber joined via an ion-conductive partitioning wall to a second ch..Material layer and electro-surgery system for electrosurgical tissue fusion...The invention relates to a biocompatible material layer for use as an intermediate layer between tissue surfaces to be fused with a fusion of body tissue. The layer of material is such that it causes ..CELL SEPARATION DEVICE, CELL SEPARATION SYSTEM AND CELL SEPARATION METHODA cell separation device which can perform a continuous processing without bonding fluorescent molecules or magnetic particles to the surface of the cell membrane, a cell separation system, and a cell..The reduction of redox-sensitive substances by bacteria of the genus Alteromonas or ShewanellaBio-treatment of aqueous effluents, in particular to remove colour therefrom, is carried out in a Continuous Oscillatory-flow Baffle Reactor. Redox-sensitive substances are reduced by means of bacteri..Automated Vitrification SystemMarket Opportunity Cryopreservation of biological materials by vitrification has made significant inroads in displacing the more conventional slow-freeze process. However, technicians must conduct a..Laplace Pressure Trop for Microfluidic Droplet Formation from Asynchronous Sources and Different InletsTech ID: 21232 Brief Description Researchers have developed a Laplace pressure trap that can fuse droplets from different inlets and fuse droplets generated at different frequencies. The device tr..Device for High Efficiency Cell Encapsulation using Novel On-Demand Droplet Generation and Impedance-Based DetectionTech ID: 21236 Brief Description Researchers have developed a novel microfluidic device that is capable of encapsulating cells at a very high efficiency. The device integrates impedance measuremen..Colloidal Self-Assembly of Droplets for High Density Microfluidic Micro-Reactor Arrays with High Throughput FunctionalityTech ID: 21274 Brief Description Researchers have developed a simple method for the rapid self-assembly of predictable high density droplet-reactor arrays for high throughput microfluidic applicat..Microfluidic Device using Dielectrophoresis Separation of Heterogeneous Cell PopulationsTech ID: 21272 / UC Case 2011-181-0 Brief Description Researchers have developed an automated microfluidic device that traps different cell populations in different chambers based on the cells’ ..Facile Method for Modifying Retrovirus Envelopes to Purify Retroviruses and/or to Enhance Gene DeliversTech ID: 21217 Brief Description Researchers have developed a novel and convenient method to molecularly tune the exterior surface of retroviruses. The glycoproteins on the surface of viruses an..High Strength Nanotechnology-based Inorganic BinderA technology platform that permits the creation of inorganic solids with very high compressive strength, which permits the creation of light weight, fire resistant, mineral foam composites. These s..Chitosan Green Tea Polyphenol Complex for Wound HealingIn recent years, oxidative stress has been implicated in a variety of degenerative process and diseases, including acute and chronic inflammatory conditions such as wound healing. Green tea polypheno..Label-Free Protein DetectionBackground Conventional methods to detect the presence or quantity of specific proteins or other molecules in biological samples rely on the use of target-specific probes such as antibodies, which c..Superior Liquid Uptake Resins for Polymer-supported Synthesis (SLURPS)Background Solid phase synthesis, or polymer-supported synthesis, is a technique for chemical transformations in which molecules are bound to a solid, such as a polymer bead, during the reaction and..Cucumber Mosaic Virus Inducible Viral Amplicon (CMVIVA) Expression SystemTech ID: 11438 / UC Case 2006-640-0 Abstract A Chemically Inducible Cucumber Mosaic Virus Amplicon Expression System for Production of Recombinant Proteins in Plant-Based Systems Full Descript..Cost-Efficient, Biodegradable Microspheres with Control of Diameter, Density, Color and Surface ChemistryBACKGROUND: Currently commercialized microspheres for flow measurement and bioscience applications are manufactured via polymerization processes that are costly or impossible to customize and require ..A New Method to Enhance Nerve GrowthBACKGROUND: Stroke and CNS injuries together cost Americans an estimated $75 billion a year in medical and rehabilitation expenses and lost productivity. Currently, there are no effective, clinicall..Method to Diagnose Giant Cell ArteritisBACKGROUND: Giant cell arteritis is an inflammatory disease that primarily affects arteries in the head and neck. In the U.S. alone, it is estimated that 200 per 100,000 people over the age of 50 deve..End-Specific Antibody to Detect ApoptosisBACKGROUND: Programmed cell death or apoptosis is a critical event in normal cellular differentiation and development as well as in degenerative diseases, cancer and aging. Currently, the most widel..Expression and Purification of ATM Protein using Vaccinia VirusBACKGROUND: Ataxia telangiectasia (AT) is a genetic recessive disorder involving a large range of symptoms including telangiectasia (dilation of blood vessels) on the eyes, face, and shoulders, ataxi..New Factor involved in Lipid DisordersBACKGROUND: Fat cells, or adipocytes, are a specialized cell type that synthesize and store fat (triglycerides) in periods of nutritional abundance, and hydrolyze these fats when needed to meet deman..Diagnostic Test for Mutations in the AT GeneBACKGROUND: Ataxia telangiectasia (AT) is a genetic recessive disorder involving a large range of symptoms including telangiectasia (dilation of blood vessels) on the eyes, face, and shoulders, ataxi..Technique for Expressing any RNA in Curcular FormAntisense mRNA and ribozymes (catalytic RNA) have great potential for controlling gene expression. A major road block remains: many linear anti-sense or ribozyme RNAs are unstable when expressed in l..Glucanase Regulation of Plant Growth and DevelopmentHydrolysis of the polysaccharides that compose plant cell walls is critical to cell expansion, and is therefore a key process in governing the growth and development of plants. Specifically, beta-gluc..Commercial Auxin SubstituteA University of California researcher has identified a low-cost, non-toxic compound that can be exogenously applied to plants as foliar sprays to annual vegetable and perennial tree crops under commer..Multiplexing Protein Binding Microarrays for Genetic AnalysisBACKGROUND: Our ability to understand and practically benefit from the control logic encoded in the human genome is currently limited by a lack of accurate information regarding promoter regulation. G..Safe and Potent Synthetic Lung Surfactant for Treating RDS and Acute AsthmaBACKGROUND: The use of lung surfactant dispersions, based on lipid and protein components extracted from animal lung tissue, has significantly reduced mortality and morbidity from respiratory distress..Enzyme for Antimicrobial and Vaccine DevelopmentScientists at the University of California have shown that a specific enzyme is an essential regulator of Salmonella virulence. This enzyme is prevalent in many organisms including most enterobacteria..Method and Probes for the Identification of Microbial Genes specifically induced during Host InfectionBACKGROUND: Pathogenic microbes express certain virulence properties only during the infection of a host. Attempts to identify these virulence factors and to develop methods to control infections by t..Novel Antisense AgentUniversity of California scientists have synthesized novel oligonucleotide analogs for use in antisense and related applications. Unlike ordinary DNA and RNA strands, the U.C. analogs incorporate modi..indian patent published " NANOGENESEQ CHIP DESIGN''NANOGENESEQ has designed an innovative sequencing system design consisting of two key components: a) The Hardware component b) The Software component The hardware component of NANOGENESEQ sequencin..Inexpensive, Sensitive, Rapid and Selective Detection of GHB (Gamma-Hydroxybutyrate)Researchers at the University of California have invented a rapid, selective, sensitive, and inexpensive enzyme-based colorimetric assay for GHB that will provide means by which: * People can prote..Use of Vanadium Bromoperoxidase as a Signal-Generating Enzyme for Chemiluminescent Systems: Test Kits and Analytical MethodsPATENT ABSTRACT: Aqueous compositions, test kits and methods can be used to detect hydrogen peroxide or vanadium bromoperoxidase by generating a chemiluminescent signal in the presence of the analy..Tough, Self-Healing Silicone MaterialsSiloxane- and organosiloxane-based materials (collectively termed "silicones") are ubiquitous in commercially available goods and high technology applications, often in the form of oils, rubbers, resi..Initiators for Block-Copolypeptide SynthesisBACKGROUND: Amino acid-N-carboxyanhydride (NCA) polymerizations employing conventional initiators (e.g. hexylamine or sodium methoxide) are plagued by chain-breaking transfer and termination reactions..Moisture-Resistant Adhesive PolypeptidesBACKGROUND: Surgical tissue adhesives provide an alternative to suturing, packing, or stapling planes of tissue together. Use of adhesives for wound closure is desirable since adhesives can be very fa..Edible Coating for Crispy Texture in Processed FoodUniversity of California researchers have discovered that a sweet-corn extract can be used to modify the texture of processed foods to improve their crispiness. The extract may be applied as an edible..Recombinant Prolactin AntagonistThe hormone prolactin (PRL) exerts various effects in a wide range of physiological processes. Research suggests that PRL may promote cellular proliferation in both breast cancer and prostate cancer c..Identification of SortaseBACKGROUND: Hospital-borne bacterial infections present a major challenge in patient care due to the rising number of strains resistant to multiple antibiotics in recent years. Gram-positive bacteria,..Identification of SortaseBACKGROUND: Hospital-borne bacterial infections present a major challenge in patient care due to the rising number of strains resistant to multiple antibiotics in recent years. Gram-positive bacteria,..Detection of ATM Mutations and Polymorphisms with MEGA-SSCPBACKGROUND: Ataxia telangiectasia is an autosomal recessive disorder characterized by progressive cerebellar degeneration, immunodeficiency, growth retardation, premature aging, chromosomal instabilit..Phosphorylation of Histone H2B as a Marker for Cell Proliferation and Differentiation in Development and DiseaseBACKGROUND: Determining the cell cycle state of human cells can provide an important method for early detection of cancerous growth, especially the detection of cells at the G2/M phase of beginning ce..Chemokine and Peptide Derivatives for Would-Healing, Fibrotic Disease Treatment, and Tumor SupressionA University of California researcher has characterized an avian chemokine that acts both directly and as an agent for various growth factors in wound-healing. The gene that encodes this protein is an..Vectors for the Recombinant Expression of Human ImmunoglobulinsMonoclonal antibodies (mAbs) are an essential tool in numerous research, therapeutic, and diagnostic applications, as mAbs can be customized to bind a desired antigen. While this is highly advantageou..Monoclonal Antibodies and Method for Detecting Dioxins and DibenzofuransPolychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are toxic pollutants which pose persistent threats to both the human population and to the biosphere in general. Al..Polypeptides and Antibodies Associated with HTLVBACKGROUND: Human T-lymphotropic viruses (HTLV) are part of a family of retroviruses called oncogenic retrovirues. HTLVs were originally identified for their ability to infect human lymphocytes, part..Tissue-Specific Gene Inactivation of Beta-1 IntegrinBACKGROUND: Beta-1 integrin is a critical member of the large family of integrin proteins necessary for cell-extracellular matrix adhesion and bi-directional signaling across the cell membrane. Conven..High-Speed, High-Resolution Impedance SensorBACKGROUND: While there has been extensive work in developing radio-frequency probes for measuring proximal impedances in air, these probes have been limited to applications using good conductors as t..Suspended Carbon Nanotubes as Mulecular SensorsBACKGROUND: Relatively large surfaces areas and great sensitivity to environmental conditions make carbon nanotubes (CNTs) very promising candidates for sensing elements. However, all existing CNT sen..Platform for Chemical and Biological Sensing by Surface Enhanced Raman SpectroscopyBACKGROUND: Surface-Enhanced Raman Spectroscopy (SERS) is an optical analysis technique that can provide molecular identification and quantification by recording a spectrum that displays characterist..Hybrid Energy Transfer for Nucleic Acid DetectionBACKGROUND: The need for efficient assays to detect DNA sequences is enormous and constantly growing. The recent increases in the number of sequenced genomes for bacterial and viral pathogens as well ..Electronic Detection of Molecular Targets, Including Proteins, Oligonucleotides and other small MoleculesBACKGROUND: While many assays exist for the detection of DNA, RNA, proteins and other molecular targets, most sensors require sample purity and rigorous controls available only under ideal laboratory..One-Step Manufacture of Nanowire BiosensorsElectrochemical biosensors based on nanotubes or nanowires could be widely used in diagnostic, research, and security applications. However, the problems associated with functionalizing and placing th..Tunable, Full-Color Electroluminescent ArrayBACKGROUND: A light-emitting diode (LED) is a semiconductor device that emits visible light when an electric current passes through it. Traditionally, LEDs were made with inorganic materials. However..Oxide-Supported Metal Nanoparticle CatalystBACKGROUND: Gold nanoparticles, particularly with dimensions less than 10 nm, exhibit unexpectedly high catalytic activities toward different types of reactions, a property not revealed in bulk gold...Novel Supramacromolecular Polymer Complexes Providing Controlled Nitric Oxide Release for Healing WoundsTechnology To overcome these deficiencies, UofToronto researchers have developed a novel, stable and biocompatible system for generating a durable release of NO. This technology is based ..Nano-Composite Polymeric Membrane System for Drug DeliveryThe Background Then human body has its own homeostatic mechanisms to regulate a variety of physiologic parameters within a certain range. In instances of disease, however, these parameters..Readily Available Unprotected Amino AldehydesThe Technology A new class of compounds, containing two functional groups, an aldehyde and an unprotected amine has been developed. This finding has solved a significant problem in complex a..A Novel Proangiogenic CompoundBackground Angiogenesis, the formation of new blood vessels from a preexisting vascular bed, plays a critical role in tissue growth and repair. Angiogenesis is regulated by a complex collaboration ..Newly Described Peptide with Actin Stabilizing ActivityThe Background The cellular cytoskeleton functions to maintain the spatial shape and volume of mammalian cells; it is crucial for functions such as locomotion (migration), endocytosis, and phagocyt..Thermal Dependent Injectable Polymer MatrixTechnology The technology is a novel drug delivery polymer matrix comprising an inverse thermal gelling polymer with an anionic polymer. This polymer matrix is faster gelling than each of the s..Novel Strains of Diabetic and Nude RatsBackground Currently, the BB rat is the only available strain that spontaneously develops Type 1 Diabetes. While the high cumulative incidence (>85% in males and females) of diabetes in BB rats, an..PoLi Implant System for Targeted and Controlled Drug DeliveryTechnology The PoLi Implant Systems have several advantages over other synthetic polymer drug delivery systems. They are made of natural, fully biocompatible and biodegradable materials. The co..Canine Embryonic Stem CellsBackground The establishment of embryonic stem (ES) cell lines has brought great promise and opportunities for regenerative medicine and pharmaceutical research. Embryonic stem cells are derived fr..Unique Treatment for Type 2 Diabetes and Islet Cell TransplantationBackground Deposition of islet amyloid polypeptide (IAPP or amylin) fibrils is associated with over 90% of cases of type 2 diabetes, and is present regardless of the obesity of the pat..Bioreactor Suite ()Abstract: A major drawback of conventional reactors has been gravity-induced sedimentation of the microcarrier beads. As cell density becomes greater, the beads require more stirring, resulting in hi..METHOD FOR INHIBITING, ARRESTING AND POSSIBLY REVERSING NON-ENZYMATIC GLYCATIONNon-enzymatic glycation and cross-linking (Maillard reaction) are well known processes which accelerate the aging of key biological molecules. For example, non-enzymatic glycation of macromolecules su..METHOD FOR INHIBITING, ARRESTING AND POSSIBLY REVERSING NON-ENZYMATIC GLYCATION IN DIABETIC PATIENTSNon-enzymatic glycation and cross-linking (Maillard reaction) are well known processes that accelerate the aging of intracellular proteins and extracellular structural proteins such as collagen and el..COMPOSITIONS AND METHODS FOR REGULATING RNA TRANSLATION VIA CD154 CA-DINUCLEOTIDE REPEATThe expression of CD154 (CD40 ligand), a member of the Tumor Necrosis Factor gene family, by activated T lymphocytes is critical in the development of humoral and cell-mediated immunity. CD154 blockad..method for IDENTIFYING AGENTS WHICH MODULATE gtpASE ACTIVITY INVOLVED IN INSULIN-STIMULATED glut4 TRANSLOCATIONInsulin treatment of fat and muscle cells causes a rapid increase in glucose transport. The basis for this effect is an increase of glucose transporters of the GLUT4 type at the cell surface. This tra..Regulatory T Cell MEDIATOR PROTEINS and uses thereofRegulatory T cells (Treg) play an important role in constant and inducible control of T cells responses in vitro and in vivo. Treg cell depletion results in the induction of autoimmune pathology and e..Nucleic acid sequences encoding luciferase for expression in filamentous fungiBioluminescence is the light produced in certain organisms as a result of luciferase-mediated oxidation reactions. The luciferase genes, e.g., the genes from luminous beetle and, in particular the luc..COMPOSITIONS AND METHODS FOR INHIBITING THE SYNTHESIS OR EXPRESSION OF MMP-1 FOR TREATING, PREVENTING, OR MANAGINGOverexpression of MMP-1 is associated with several pathological conditions, including the irreversible degradation of cartilage, tendon, and bone in arthritis and the degradation of collagens I and II..COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING CANCER VIA MODULATING UBE1L AND/OR ISG15Individuals with acute promyelocytic leukemia (APL)(FAB M3) express oncogenic promyelocytic leukemia (PML)/retinoic acid receptora (RARa). All-trans-retinoic acid (RA) treatment causes complete remiss..NOVEL IMMUNOTHERAPY FOR OVARIAN CANCERDartmouth investigators and their colleagues at the University of Kansas have discovered a novel method for rescuing cytotoxic T lymphocytes from destruction by ovarian carcinoma cells in vitro using ..A RELIABLE, NON-RADIOACTIVE METHOD FOR MONITORING ACCUMULATION OF CHOLESTEROL INSIDE MAMMALIAN CELLS AFTER LOADING WITH LOW DENSITY LIPOPROTEIN (LDL)Agents identified as cholesterol inhibitors are useful in preventing and treating cardiovascular and neurodegenerative diseases associated with over accumulation of cholesterol in cells. These agents ..IDENTIFICATION AND USES OF A NOVEL TRANSCRIPTIONAL ACTIVATOR THAT USES VISIBLE LIGHT AS ITS INDUCERDartmouth researchers are contributing to the rapidly emerging field of regulatable gene expression. Recent research at Dartmouth has identified a protein complex that activates gene expression in res..USE OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) FOR TREATMENT OF NEUROPATHIC PAINChronic pain is a dominant health problem. It is the most common reason to seek a physician's care with nearly 40 million office visits scheduled annually. Pain costs the U.S over $100 billion each ..Novel Method of Monitoring AngiogenesisAngiogenesis is the formation of new capillary blood vessels as outgrowths of pre-existing vessels. This tightly regulated process plays a vital role in many physiological processes, such as embryoge..NOVEL USE OF ASPIRIN FOR COLON CANCER PREVENTIONThe American Cancer Society estimates that colorectal cancer will be diagnosed in 147,000 Americans in 2003 and will cause 57,100 deaths, making it the second-leading cancer killer. A seven-ye..DELINEATION OF A NOVEL PATHWAY THAT REGULATES HUMAN CD154 (CD40 LIGAND) GENE EXPRESSIONThe expression of CD154 (CD40 ligand) by activated T lymphocytes plays a central role in humoral and cellular immunity. The fundamental importance of this protein in mounting an immune response has m..METHODS OF DIAGNOSING, PROGNOSTICATING AND TREATING COLLAGENASE-1 RELATED DISEASESDegradation of the extracellular matrix is part of the pathological process associated with many diseases: e.g., joint destruction in arthritis, invasion and metastasis in cancer, bone dissolution in..COMPOSITIONS AND METHODS FOR TREATING AND IDENTIFYING THERAPEUTICS FOR CYSTIC FIBROSISCystic fibrosis (CF) is one of the most common autosomal recessive diseases in the human population. CF as a disease typically involves several different epithelial tissues. However, the principal c..POWERFUL RESEARCH TOOL FOR SCREENING AND TESTING OF CHOLESTEROL REDUCING COMPOUNDSAccumulation of cholesteryl esters as cytoplasmic lipid droplets within cells of human aortic tissue is a characteristic feature of early lesions of atherosclerotic plaque. These cholesteryl esters a..NEW TREATMENT FOR LOW BACK PAINLow back pain is a major clinical problem second only to the common cold in its financial and symptomatic impact on human suffering. It has been estimated that 20 percent of the adult population h..IDENTIFICATION AND USES OF A DNA DIGESTING ENZYME POTENTIALLY INVOLVED IN THE PATHWAY OF APOPTOSIS AND CELL DEATH AND USEFUL IN CONDITIONS SUCH AS CYSTIC FIBROSISDartmouth researchers are contributing to the rapidly emerging field of apoptosis, which describes a pathway of cell death that is essential for normal human development and that can, when aberrant, l..DISCOVERY OF A NEW CLASS OF ANTITUMOR AGENTSDartmouth researchers have synthesized a novel class of antitumor agents. These potential new drugs were designed to bind more tightly to cancer cell DNA than many conventional anticancer drugs by a ..ALTERNATIVE SPLICING OF THE MCL-1 GENE USEFUL IN CANCER THERAPYMCL1 is a member of the BCL2 gene family which is involved in controlling cell viability and immortalization. Because of their ability to keep cells alive, these gene products can contribute to cance..ANTI-MICROBIAL PROTEASE INHIBITORHuman morbidity and mortality due to bacterial infections has become a problem of great concern due to the well-publicized dramatic increase in the frequency of infections caused by bacteria that are ..A NOVEL METHOD TO ENHANCE THE ACTIVITY OF ROUTINELY USED ANTICANCER AGENTSDartmouth researchers have discovered a new methodology that can enhance the activity of routinely used anticancer agents. In particular, this method appears to be selective for tumors that are defec..NOVEL HIGH-THROUGHPUT SCREENING ASSAY FOR IDENTIFICATION OF CHOLESTEROL INHIBITORSDartmouth scholars developed a high-throughput screen comprised of a cell-based assay for identification of chemical inhibitors which block internalization of plasma membrane cholesterol from entering..METHODS FOR IMMUNIZATION OR TREATMENT OF HUMANS AND ANIMALS AGAINST VIRUSES (HIV INCLUDING), INFECTIOUS AGENTS, CANCER AND OTHER GENETICALLY TREATABLE MALADIESApicomplexan parasites are significant pathogens of humans and animals, and cause diseases such as toxoplasmosis, malaria, cryptosporidiosis, theileriosis, and many others. For these reasons various ..Microwave Powered Sterile Access Port (MSC-22802)Abstract: This technology was developed to provide a less expensive, easy-to-use method for eliminating potential contamination during transfer of materials into and from bioreactors or other sample ..MODULATION OF CELL PROLIFERATION USING HYBRID POLYPEPTIDESMODULATION OF CELL PROLIFERATION USING HYBRID POLYPEPTIDES TECHNOLOGY REVIEWPresent therapeutic strategies for cancers such as colon cancer often involve highly toxic treatments. Further, in many case..Mouse Null for Pigment Epithelium-derived Factor (PEDF) (21077)Investigators at Northwestern University created an animal model useful for analyzing the role of pigment epithelium derived factor (PEDF), an endogenous inhibitor of angiogenesis, in the onset and pr..Bioreactor (Cartridge) for in vitro Pharmacokinetic/Pharmacodynamic SystemAbstract (Set) JHU scientists have developed a special bioreactor (cartridge) that permits growth of protozoan parasites for studies on the pharmacokinetic/pharmacodynamic (PKJPD) relationships of ex..Screening Method for Smith-Lemli-Opitz SyndromeUsing this method it is possible to determine, from a small blood sample taken from a newborn, whether there are abnormalities in the sterol content of the blood. The overabundance of certain sterols ..Precision Genetic Regulatory ElementsNew versions of the LacI repressor protein with increased DNA binding affinity. The lac repressor protein (LacI) is a genetic regulatory protein widely used to control the expression of cloned genes ..Cloning and Expression of Ginkgo biloba Levopimaradiene SynthaseGinkgo biloba leaf extracts have been used for centuries to treat cerebrovascular and cardiovascular diseases. Recently, the American Medical Association endorsed the Chinese herb as a viable alternat..Diterpene Production in Recombinant YeastThrough genetic modification of Saccharomyces cerevisiae and defined culture conditions, the production of diterpenes through fermentation has been achieved. This provides an opportunity to synthesize..TGF-Beta Conjugated Growth ScaffoldsTGF-Beta Conjugated Growth Scaffolds can be used to increase the mechanical strength of the cultured tissues by increasing extracellular matrix production. As the growth factor remains on the scaffold..Prefabricated Tissue Engineering Bone Plug for Bone Defect RepairComposed of materials for engineering bone tissue, this plug may be inserted into a bone defect and then used to inject and hold in place polymeric materials that enhance bone regeneration. Other appl..Encapsulation of Radioisotopes in Carbon Nanocages for BioMedical ApplicationsAbstract Encapsulation of Radioisotopes in Carbon Nanocages for BioMedical Applications Technology ID: #23017 Investigator: Prof. Boris Yakobson Delivery of radioactive isotopes to specific targ..Non-Invasive Bone and Joint Damage Detection DeviceRadiography is an important diagnostic tool in medicine but unfortunately suffers from certain limitations. X-ray detection equipment is not totally portable, cannot detect certain types of injuries a..Development of a Novel Confocal Laser Scanning Microscope for Functional Recording of Fast Neuronal ActivityDendrites of neurons in the central nervous system are the principal sites for excitatory synaptic input. These neuronal dendrites are known to possess active computational properties also. Currently,..Alternating Recombination Method for Assembling DNA FragmentsA process for recombination assembly of a series of cloned DNA fragments into a large ordered arrangement. Potential uses of this technology include: . Analysis of function of large interrupted codi..Abstract Method for Assembling PCR Fragments of DNAA process for assembling a series of DNA fragments generated by PCR into an ordered circular arrangement for replication and genetic work in cells. The method uses the 3' overhangs created by excision..Nitric Oxide-Producing Hydrogel Materials for Preventing Arterial BlockageEndothelial cells, normally present as a monolayer in the arterial wall, are believed to play an important role in the regulation of smooth muscle cell proliferation in vivo. Endothelial cells are ser..Metabolically-Enhanced Microbial StrainThe key element in this new technology is that metabolic energy which would normally be diverted away from biosynthetic processes is recaptured in the form of NADH. During fermentation with this strai..Bacteriophage Genes as the Basis for New AntibioticsDiscovery of wide-spectrum bacteriocidal proteins creates new opportunities for (a) improving phage therapy and (b) identifying important bacterial drug targets and developing new antibiotics. These b..MUC7 20-mer Peptide: Novel and Promising Antifungal and Antibacterial Therapeutic AgentThis invention encompasses peptide derivatives of a naturally occurring protein found within the human body. These peptides have been shown to posses potent antifungal and antibacterial activity compa..Recombinant Baculovirus that Produces Human Topoisomerase IIntroduction Eukaryotic topoisomerase I (Topo I) is capable of relaxing both negatively and positively supercoiled DNA. The enzyme catalyzes changes in the superhelical state of duplex DNA by transien..Cell line expressing functional alpha1D-adrenergic receptorsIntroduction The alpha1D-adrenergic receptor (AR) is a major regulator of cardiovascular and central nervous system function. Targeting AR is thus of major interest to the pharmaceutical industry for ..Selective Detection of PhosphoproteinsIntroduction Mass spectrometry enrichment and detection of phosphoproteins is critical to cancer research and drug development, among many applications. In MALDI-TOF mass spectrometry, metal plates de..Continuous Production of Microcellular FibersIntroduction In microcellular plastic foams, inert gas is dissolved in thermoplastic under high pressure. The forced evacuation of this gas during processing creates pores (or cells) within the final ..Microcellular Foaming of Cyclic Olefin Copolymer (COC)Introduction Cyclic olefin copolymer (COC) is a commercially available thermoplastic. It possesses exceptional clarity in its natural form, similar to that of glass, and it has high moisture resistanc..Keratinocytes Derived from Human Embryonic Stem CellsSummary The investigator has discovered a method for isolating and propogating keratinocytes from human embryonic stem (ES) cells. Production of an isolated keratinocyte culture proceeded step-wise fr..A Novel Class of HIV Therapeutics: Monoclonal Antibodies that Neutralize Previously Resistant HIV Primary IsolatesSummary Background: Molecular studies of the genomic organization of HIV-1 show that it encodes a number of genes common to all retroviruses, such as the gag, pol, and env genes. The env gene of HIV-1..Small Molecule Transcriptional Activators: Lead Agents for Gene TherapySummary One difficulty that has been encountered with the use of transcriptional activation systems in gene therapy is that overexpression of transcriptional activators in cells typically inhibits gen..PTP-NP, A New Member of the Receptor Protein Tyrosine Phosphatase Family, Implicated in Development of Nervous System and Pancreatic Endocrine CellsSummary The Flanagan Lab discovered a new member of the protein tyrosine phosphatase (PTP) family, called PTP-NP (for neural and pancreatic). The regulation of protein tyrosine phosphorylation is an i..A New p53 Cell-Based AssaySummary Harvard researchers developed a reliable, high-throughput screening assay to identify activators and inhibitors of p53. This cell-based luminescence assay measures the level of a reporter gene..Modular Conditional Knockout: Precise Temporal Control of Protein Degradation in Living CellsSummary Polyubiquitinated proteins in eukaryotes are directed to the proteasome for degradation. It is generally accepted that proteasome-mediated proteolysis depends strictly upon ubiquitination, as ..Novel Gadolinium nanoparticles for Magnetic Resonance Lymphatic ImagingIntroduction Gadolinium (Gd3+) is chelated with diethylenentriaminepentaacetyl (DTPA) to provide contrast in magnetic resonance (MR) imaging to identify pathogenic tissues. Unfortunately, the Gd3+-DTP..Nanocellular Foaming of Ultra High Molecular Weight Polyethylene using UltrasoundIntroduction Ultra high molecular weight polyethylene (UHMWPE) is a thermoplastic consisting of molecules of incredibly long chains with molecular weights of several million. It has the highest impact..Production of Palladium Nanostructures with Shape Selection by Adding BromideIntroduction Single-crystal, one-dimensional nanostructures of palladium are attractive as interconnects for fabricating nanoscale electronic devices. Polycrystalline, mesoscopic wires made of palladi..Copper Chloride-mediated Synthesis of Silver NanowiresIntroduction Owing to the high electrical and thermal conductivity of bulk silver, the synthesis of Ag nanowires has been and continues to be an area of active research. The properties and application..Gold VisionIntroduction A neuron or group of neurons that senses or receives light within the eye is known as a photoreceptor. Damaged or diseased photoreceptors lead to impaired vision or blindness. Local stimu..A Microfluidic Device and Methodology for Rapid, Quantitative Determination of Analyte Concentration in a Fluid SampleIntroduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, especially for biosensors and environmental monitoring. One recent area of interest is p..Platelet Clotting Force ArrayIntroduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, such as point-of-care diagnostic devices. These microscale diagnostic platforms will ena..Programmable Generation and Transport of Droplets on Microscale Surface Texture RatchetsIntroduction Advances in microfluidic technology are constantly opening doors to new and exciting applications. Currently, many laboratory processes can be combined on a single chip commonly only mill..Cell and Microparticle Separator Employing Patterned GroovesIntroduction Microscale enrichment and separation are important for various research, biomedical, and industrial uses. Conventional means for these processes typically require specific labels— eith..Signal Amplification Method for SPR-based Chemical DetectionIntroduction Surface plasma resonance (SPR) is a general spectroscopic method for sensing refractive index changes near the surface of a metal film. Its sensitivity to these changes provides a versati..3-D Tissue Culture ChamberIntroduction Many of the seminal findings in cell and molecular biology have come from cultures of cells grown in two dimensions but the limitations of biology in just 2D are becoming clear. Cells in ..Active Biomimetic Cilia Using NanowiresIntroduction Critical challenges in emerging bio-fluidic devices lie in bio-compatible transport of small sample volumes and bio-reaction enhancement without damaging biomolecules. In nature, biologic..Purified Compositions of Stem Cell Derived Differentiating CellsIntroduction Stem cells have a capacity for both self-renewal and the generation of differentiated cell types. Embryonic Stem (ES) cells are derived from cultures of inner cell mass (ICM) cells, and h..Chitosan/alginate hybrid scaffoldsIntroduction For the past decade, a large number of natural and synthetic porous polymeric materials have been extensively studied for use as scaffolds for bone tissue engineering. Although these effo..HLA Homozygous CellsIntroduction Although stem cells have great potential in regenerative medicine, they can only be used effectively in recipients that have the same histocompatibility type or the cells will be rejected..Microfabricated Thermocouples for Microfluidics and MicroreactorsIntroduction Continued strong growth is projected within the biochip products and services marketplace worldwide. As the number and complexity of reactions and separations that are carried out using b..PROFILED REGULATORY SITES USEFUL FOR GENE CONTROLIntroduction The invention provides methods for quantitative profiling of chromatin sensitivity to a DNA modifying agent. The invention also relates to methods for identifying regulatory sites in a ge..METHODS AND COMPOSITIONS FOR DIAGNOSING HEPATOCELLULAR CARCINOMAIntroduction Currently, it is difficult to diagnose HCC. Methods employed generally rely on imaging techniques such as MRI, CT, and ultrasound and are of little use in detecting the disease in its ear..CNS Tissue-selective Transgenic Animal Mouse ModelIntroduction A central nervous system (CNS) specific knockout system has been unavailable thus far due to technical limitations. Recent advances have provided exciting data based on the use a liver-sp..Scn1A knockout mouse-a genetic animal model for human epilepsyIntroduction Epilepsy is one of the most common neurological disorders. Its pathophysiology is poorly understood and the available pharmacotherapies are effective only in a fraction of patients with f..BCRP expressing cell linesIntroduction The breast cancer resistance protein (BCRP) is an ATP-binding cassette efflux transporter originally identified by its ability to confer multidrug resistance in cancer cells. BCRP mediate..Dact1 (Dpr1/Frodo1) Conditional Knockout MiceIntroduction Wnts are secreted signaling proteins important in development and disease in multicellular animals. These signaling proteins help regulate cell fate specification, cell morphology, cell p..M1 Muscarinic Acetylcholine receptor Knockout MiceIntroduction Muscarinic acetylcholine receptors are members of the G protein-coupled receptor superfamily expressed in neurons, cardiomyocytes, smooth muscle, and a variety of epithelia. The M1 recept..A Mouse Model for OsteoporosisIntroduction Osteoporosis, an age-related disease in which loss of bone mass causes skeletal deformities and fractures, affects nearly 20 million people in the US, mostly women. A major complication i..Type III Adenylyl Cyclase Gene Knockout MiceIntroduction The olfactory sensory system has the remarkable capacity to detect and discriminate among a wide array of odorants and translate them into cognitive representations. Cyclic nucleotide–g..Zinc Transporter-3 Knockout MouseIntroduction The presence of histochemically reactive zinc within synaptic vesicles defines a subset of neurons that have been termed zinc-enriched (ZEN) neurons. Because ZEN neurons are prevalent thr..PDL2-Ig Fusion ProteinIntroduction T cell activation and tolerance are critically regulated by costimulatory molecules, especially those in the B7 and CD28 superfamilies. PD-1, a novel member of the CD28 family, is express..B7-H-Ig Fusion ProteinIntroduction T cell activation and differentiation require not only T cell receptor recognition of the antigen–MHC complex but also costimulation through the interaction of accessory molecules on AP..Type I Adenylyl Cyclase Knockout MouseIntroduction The type I adenylyl cyclase (I-AC) is neurospecific and expressed in areas of the brain that show long-term potentiation. This enzyme is thought to play an important role in the developme..A Yeast Ligand SensorIntroduction The yeast ligand sensor is a novel approach for the detection and quantification of ligandbinding, an issue of great interest in drug discovery and other areas. The approach is a protein-..NPY-Deficient miceIntroduction NEUROPEPTIDE Y (NPY), a 36-amino-acid transmitter distributed throughout the nervous system, is thought to function as a central stimulator of feeding behaviour. NPY has also been implica..SirT1 Conditional Knockout MiceIntroduction SirT1 is a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase capable of modifying the activity of many transcription factors that have been implicated in the physiology and pa..Thrombospondin 2-null miceIntroduction Thrombospondin 2 (TSP2), a matricellular protein with a primary role in modulating cell matrix interactions, has been implicated in tissue repair and foreign body responses. Technology de..SV2B Knockout MouseIntroduction Synaptic vesicle protein 2 (SV2) is a membrane glycoprotein found only in the secretory vesicles of neural and endocrine cells. It appears to be unique to vertebrates, suggesting that it ..Cyclic nucleotide phosphodiesterase 7B (PDE7B)Introduction Cyclic nucleotide phosphodiesterases (PDEs) are enzymes hydrolyzing the second messengers adenosine and guanosine 3',5'-cyclic monophosphates (cAMP and cGMP). The human genome encodes 21 ..SV2A/B Double Knockout MouseIntroduction Synaptic vesicle protein 2 (SV2) is a membrane glycoprotein found only in the secretory vesicles of neural and endocrine cells. It appears to be unique to vertebrates, suggesting that it ..Fluorescent Microglial Cell LinesIntroduction Microglial cells are the resident immune cells of the central nervous system. Upon brain damage, these cells are rapidly activated and transform from a resting state into activated microg..A Microfluidic Device and Methodology for Rapid, Quantitative Determination of Analyte Concentration in a Fluid SampleIntroduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, especially for biosensors and environmental monitoring. One recent area of interest is p..Ultrasound Target Vessel Occlusion using MicrobubblesIntroduction Ultrasonography is a noninvasive medical imaging technique, which utilizes ultrasonic waves in order to visualize soft tissue within the body. Advances in this technology have led to a th..Pre-Surgical Cauterization during Minimally Invasive Endoscopic Procedures Using UltrasoundIntroduction Surgery is an essential tool in the treatment of many pathologies. Hundreds of thousands of surgical procedures are performed each year that result in the full or partial removal of organ..Platelet Clotting Force ArrayIntroduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, such as point-of-care diagnostic devices. These microscale diagnostic platforms will ena..Dynamic Characterization of Particles Using Flow CytometryIntroduction Flow cytometry is an increasingly useful analytical technique that utilizes the scattering of laser light to interrogate a variety of microparticles, including microorganisms, cells, and ..Tissue-Engineered Urinary Bladder Using Autologous CellsIntroduction There is a variety of reasons that a person’s bladder may fail or require removal, including bladder acontractility, cancer, and cystitis. Unfortunately, conventional artificial bladder..Advanced Biomimetic Surfaces for Surface-Enhanced Raman Spectroscopy (SERS)Introduction Raman spectroscopy characterizes molecules by their Raman scattering. As incoming light scatters off a molecule, most does so elastically, neither gaining nor losing energy, and this is k..Respiratory Detection System (RDS)Introduction Respiration rates are an important indicator of cellular and metabolic states in cells ranging from mammalian to bacterial, from individuals to large populations. Unfortunately, conventio..Technique for Detecting Loose Arthroplasty ComponentsIntroduction Due to traumatic injury, severe arthritis, and similar conditions, total joint replacement surgery (or arthroplasty) is becoming increasingly common. Despite the field’s maturity, howev..Guided cell patterning on gold-silicon dioxide substrates by surface molecular engineeringIntroduction Cellular patterning on silicon substrates is the basis for development of integrated cell-based biosensing devices, for which long term cell selectivity and biostability remain a major ch..Ultrasonic Probe for Determination of Kidney Stone SizeIntroduction Kidney stones are a common problem for men and women worldwide that can cause great pain and lead to complications, such as infection. Conventional treatments such as extracorporeal shock..Controllable Transverse Rotation AdapterIntroduction The process of fitting prosthetic limbs to amputees can be a long process filled with trial and error, and it is exacerbated in lower limb amputees due to painful shear stress caused by t..New biocompatible and biodegradable polymersIntroduction Porous biodegradable scaffolds are ideal materials on which, new tissue may be grown. These new tissues are used as graft material to replace damaged tissue removed during surgery. These ..Fluid flow assisted dielectrophoretic alignment and sorting of dielectrophoretic alignment and sorting ofIntroduction The accurate and precise sorting and deposition of nano/bio materials within a nano- or micro-environment is critical for the functionality of devices such as biochips. Fluid flow in a mi..Clutter Rejection Filters for Doppler Optical Coherence TomographyIntroduction Doppler optical coherence tomography (DOCT) is a recently developed technology that can image blood flow with high special and temporal resolution. Technology description Researchers at t..Flexible Fiber-Optic Scanning Multiphoton or Harmonic Miniature Imaging ProbeIntroduction Endoscopes are increasingly involved in performing common surgical procedures and in diagnosing cancer and other medical conditions. New technologies can demonstrate significant cost savi..Gold VisionIntroduction A neuron or group of neurons that senses or receives light within the eye is known as a photoreceptor. Damaged or diseased photoreceptors lead to impaired vision or blindness. Local stimu..Tissue-Engineered Vascular GraftIntroduction Vascular disease affects approximately 10 million Americans and is a leading factor in heart disease, stroke and diabetes. Tissue engineering offers a way to address failing organ systems..Dynamic Change of Focus for True 3-D, Scanned Retinal DisplaysIntroduction Generating true 3-D computer displays will enable the creation of more realistic and informative images, allowing improved functionality when relying on visual display data. Technology de..Design of Surface Plasmon Biosensor Based on Self-Referencing and Digital Window SystemIntroduction Surface Plasmon resonance (SPR) has attracted strong attention as a biosensor in the past two decades because it can provide label-free, real-time detection with high sensitivity. Technol..Biomaterial with Engineered VascularizationIntroduction Porous biomaterials allow the penetration of nascent networks of blood vessels. The advantage of these materials is that specific biological “training molecules” can be inserted in th..Intracellular Delivery VectorIntroduction Some drugs require cellular uptake to be effective and methods to increase cellular uptake are desired to improve on the efficacy and reduce the side-effects of certain drugs. One way to ..Thin-film BioreactorIntroduction The large scale production of biological materials requires the use of bioreactors. Bioreactors can also be used in biologically mediated chemical conversions and waste management. Tradit..Protein Microarray Fabrication with Novel FunctionalizationIntroduction Protein microarrays are enjoying increasing use in both research and diagnostic applications. One of the key challenges in protein microarray manufacture is the fixation of the protein or..Targeted Gene Modification by Parvoviral VectorsIntroduction Though the development of integrating vectors based on eukaryotic viruses has made possible the efficient introduction of genes into mammalian chromosomes, there are many situations where..A method for quantitative, proteome-wide analysis of protein phosphorylationIntroduction Protein phosphorylation is one of the most important regulatory events in cells. The state of activity of numerous enzymes and processes and the association of specific proteins into func..Carbon Nanotubes by Electrospinning with a Polyelectrolyte and Vapor Deposition PolymerizationIntroduction Ever since the discovery of carbon nanotubes they attracted a great deal of attention due to the myriad of possible applications, such as in fuel cells, lithium-ion batteries, and superca..Carbon Nanotubes by Electrospinning with a Polyelectrolyte and Vapor Deposition PolymerizationIntroduction Ever since the discovery of carbon nanotubes they attracted a great deal of attention due to the myriad of possible applications, such as in fuel cells, lithium-ion batteries, and superca..Solution Processable n-Type polymersIntroduction Conjugated polymers and organic semiconductors promise great advances in electronics because of the benefits they offer over silicon, including being cheaper with less demanding manufactu..Microporous MicromoldingIntroduction In microcellular plastic foams, inert gas is dissolved in thermoplastic under high pressure. The forced evacuation of this gas during processing creates pores (or cells) within the final ..Induction Ionization Interface for Mass SpectrometryMass spectrometry relates to the determination of the molecular weights of individual molecules by their conversion into ions in a vacuum and then subjecting them to an electric or magnetic field or b..3-D Tissue Culture ChamberIntroduction Many of the seminal findings in cell and molecular biology have come from cultures of cells grown in two dimensions but the limitations of biology in just 2D are becoming clear. Cells in ..EOS Vectors Select for Pluripotency During iPS Cell Reprogramming (RDLP# 605)This invention relates to the creation of a novel stem cell expression cassette called EOS that restricts reporter expression to embryonic or induced pluripotent stem cells.A Novel Catalyst Technology for the Polymerization of ?-OlefinsThe Invention A novel catalyst technology for the polymerization of alpha -olefins was developed including several families of pre-catalysts based on early transition metal complexes of amine-phenola..Increased Fungal Biomass for Bio Ethanol ProductionThe Invention Dr. Amir Sharon and his team from Tel Aviv University have developed a transformation-based approach through which fungi can be modified to be less sensitive to external conditions and ..A Potential Target For Discovery and Development of Novel Antiviral Agents Against Porcine Endogenous RetrovirusThe Invention Researchers in Tel Aviv University have cloned and characterized Reverse Transcriptase (RT) of PERV-B - a variant that infects human cells and, hence, might infect human recipients of..Self Assembled Peptide HydrogelThe Invention A breakthrough Self Assembled Peptide Hydrogel (SAPH) has been developed by Professor Ehud Gazit and his team at Tel Aviv University. SAPH is a safe, self assembled, biocompatible, re..Self Assembling Peptide NanotubesThe Invention Aromatic dipeptides have been demonstrated to self-assemble into discrete nanotubes that are, upon design, either sensitive or resistant to enzymatic degradation. Such nanotubes are hom..Edible Anti-Adhesion Material for the Treatment of Oral BacterialThe Invention A high-molecular-weight, non dialyzable material (NDM) isolated from Cranberry juice, specifically inhibits adhesion and dissociates co-aggregates of oral bacteria. NDM act preferably o..Edible Anti-Adhesion Material Derived From Cranberry for the Treatment of Helicobacter Pylori InfectionThe Invention An edible, high-molecular-weight, non dialyzable material (NDM) isolated from Cranberry juice inhibits specific adhesion of H. Pylori to immobilized human mucus and to cultured gastric ..Over-Expression of Membrane Proteins in Bacterial SystemThe Invention The invention provides for an increase in the expression of heterogeneous membrane proteins as well as crystallization ability. This is achieved by addition of hydrophilic alpha-helical..Targeted filamentous bacteriophages as therapeutic agentsThe Invention Targeted drug-carrying filamentous bacteriophages have been developed as a novel therapeutic approach for the treatment of infectious diseases and cancer. The phages are genetically-mod..Novel baby bottle nipple that mimics breast feedingThe Invention A new nipple for baby bottles has been developed that mimics breast feeding. The structure of the new nipple is based on the functional architecture of the breast nipple anatomy, thus e..Novel oral formulation of InsulinThe Invention Gagomers are novel particles (neither liposomes nor microspheres/nanospheres) composed of hyaluronan shell which is crossed linked to phospholipids and can be generated either as micr..Collagen fibers from a soft coralA novel source of collagen manifested as fibers derived from certain species of soft corals has been isolated. The New Collagen fibers are strong and flexible compared to commercial collagen. The fi..NOVEL ANTIMICROBIAL PEPTIDESBACKGROUND Ai2 Limited is a University of Manchester spinout company that aims to become a significant player in the global anti-infectives market. The company’s focus is on developing novel anti-mi..CORTICOSTEROIDS WITH REDUCED SIDE EFFECTSBACKGROUND Glucocorticoids (GCs) have been used therapeutically for many years to treat a range of inflammatory conditions as immunosuppressants and in the treatment of certain cancers. These compound..OPTICIN A TREATMENT FOR CANCER AND ANGIOGENESISBACKGROUND Opticin is a protein present in the eye (in the vitreous humour) and was discovered at University of Manchester by Dr Paul Bishop. Uniquely Opticin has been found to exhibit both cytotoxic ..A FUNCTIONAL FOOD WITH INDICATIONS FOR PEPTIC ULCERSBACKGROUND 1 in 10 people are affected by peptic ulcers over the course of their lifetime. Incidence of the condition is set to increase as the population ages. Current treatment relies on combination..NOVEL TISSUE MARKER FOR STRATIFYINGBACKGROUND Research at the University of Manchester has identified a new tissue marker with potential use in the stratification of breast cancer patient groups and improved targeting of treatment for ..SPINAL DISC NUCLEUS REPLACEMENTBACKGROUND In the last 10 years commercial interest in treatment of spinal degeneration in relation to back pain has increased with a large number of devices competing in a market estimated to be wort..PRODUCTION OF NOVEL HUMAN COLLAGENSBACKGROUND A powerful new platform technology for the production of human collagens is being developed in the Kadler Centre for Cell-Matrix Research within the Department of Life Sciences at the Unive..eLUNSERS: A SOFTWARE TOOL FOR MONITORING THE SIDE-EFFECTS OF NEUROLEPTIC DRUGSBACKGROUND Neuroleptics are the drugs of choice in the treatment of schizophrenia, bipolar mania and related disorders but suffer from troublesome side-effects such as drug induced parkinsonism, restl..Collaboration/Licence Opportunity Size and Permeability Selective Encapsulation and Delivery ofBACKGROUND Although there is considerable research being carried out in the area of hollow sub-micron constructs for the purposes of encapsulation of useful therapeutic entities, most of the processes..NOVEL ANTI-HELMINTHICBACKGROUND Gastrointestinal nematode infections are amongst the commonest infections of man and animals worldwide. Collectively 1 in 3 people on the planet are infected by at least one species and app..EXCIPLEX ™ A HIGHLY SENSITIVE NUCLEIC ACID FLUORESCENT DETECTION SYSTEMBACKGROUND Conventional fluorescent dyes used in nucleic acid detection methods suffer from a number of limitations. High backgrounds result in false positives and a reduction in sensitivity. The smal..ENZYME TARGETTED THERAPEUTICSBACKGROUND Enzymes, especially proteases play essential roles in disease specific processes and are valuable targets for therapeutic intervention. A number of methods of targeting enzymes have been us..Kenaf plants with elevated fiber contentThe Invention Transgenic Kenaf plants (Hibiscus cannabinus L.) have been developed by modifying the endogenous concentration of gibberellins using anti-sense technologies. These novel Kenaf plants h..ZNF206: A Novel Regulator of Embryonic Stem Cell Self-Renewal and PluripotencyZNF206: A Novel Regulator of Embryonic Stem Cell Self-Renewal and PluripotencyLife Extension Through Neurofibromin Mitochondrial Regulation and Antioxidant Therapy for Neurofibromatosis-1 in Drosophila...Background: Anti-oxidant and anti-aging compounds have been screen using other animal models. However, there was no clear understanding of the molecular basis for how the screening worked and the sys..Mitochondrial DNA Variants Associated with Metabolic SyndromeBackground: Over the past 25 years, the Wallace's laboratory discovered that the variation in the maternally-inherited human mtDNA forms a single mtDNA tree in which the branches of the tree are regi..Energy-Saving Technological Method for Long-Term Storage of Bio-Degradable TissueBackground: Currently the critical storage of bio-degradable tissue for long periods of time is done at -70" C. This temperature does provide nearly unlimited storage time. Storage at -70' C is subst..Photo-electric Device and Method for High Throughput Activation, Guidance and Poration of Targeted Cells with High Spatial ResolutionBackground: In biomedical research, controlled modulation of physiological functions of various excitable cells such as skeletal, cardiac and neuronal cells is important. The information derived from..Mouse Model of Cardiac and Muscle Disease and Cancer Caused by a Mitochondrial DNA Point MutationBackground: It is becoming increasingly clear that mitochondrial DNA (mtDNA) base substitution mutations are a common cause of age-related degenerative diseases as well as cancer. However, no mouse m..Integrated Biomedical Multimodality Imaging Probe - Optical Coherence Tomography/Ultrasound/Photoacoustics Imaging SystemBackground: In clinical applications for the examination of cardiovascular, cerebrovascular, leg and other vessels, ultrasound imaging (USI) and optical coherence tomography (OCT) are two of the most..Method and System of Elasto-Optical Tomography for Breast Cancer ImagingBackground: Currently, X-ray mammography is the widely accepted method for the detection of changes in the breast that may be cancer. However, this screening technique lacks specificity to determine ..Accurate Classification of MLH1/MSH2 Missense Mutations with MAPP-MMRBackground: During genetic testing of the human MLHl and MSH2 genes, missense variants are sometimes encountered. It is difficult to tell if these variants are benign or deleterious. Technology: T..APE/REF-1 as a Drug Target for Acne and Development of Potential APE/REF-1 Inhibitors for Prevention and Therapy of Acne VulgarsisBackground: Acne vulgarisis the most common skin disorder, and while it usually appears in adolescence, adults can get it too. The pathogenesis of acne is complex and multifactorial. According to the..A Robust Reporter Ssystem to Identify Bone Morphogentic (BMP) ActivityBackground: Bone Morphogentic Proteins (BMP)s are involved in various developmental processes, but are most famous for the activity to stimulate bone formation. Technology: Through phylogenetic fo..Fiber Optic Probe and Method for Optical Trapping, Ablation, Excitation and Detection of Microscopic ObjectsBackground: Manipulation of microscopic objects by laser methods has been used since the 1970s. Both laser tweezers (used to hold microscopic objects in place) and optical scissors (used to conduct d..Method and Apparatus for Performing Qualitative and Quantitative Analysis of Wounds Using Spatially Structured IlluminationBackground: Use of instruments to assess etiology and status of chronic wounds is still in an embryonic state. Clinicians rely primarily on clinical features such as wound size, location, depth, and ..Method to Develop Mutant Protein LibraryBackground: Current technologies used to develop novel protein and antibody libraries have been met with limited success. Specified and controlled distribution of mutations relative to the parent pro..Novel Antenna Angiography CatheterBackground: Cardiac catheterization is typically performed with stiff-tipped catheters. In order to engage a blood vessel orifice, the stiff tip must be positioned at a precise location, and in the c..Fast Lysis Cell TrapsBackground: Chemical cytometry involves the use of high-sensitivity analytical tools, such as mass spectrometry, electrochemistry and capillary or microfluidic separation methods to characterize sing..A Model of Heterogeneous Ventilation and Nitric Oxide Production in the LungsBackground: Asthma is a pulmonary disorder characterized by chronic airway inflammation and airflow obstruction that is widespread, but variable in space and time. Although airflow obstruction is rou..Novel Method Using Laser in Assays to Induce MechanotransductionBackground: Mechanotransduction, the process by which cells convert mechanical stresses to a biochemical signal, influences many cell functions including cell motility and proliferation and also modu..Ergonomic Tracheal Suction SystemBackground: Tracheal suction catheters used today by respiratory therapists have a number of drawbacks. First, the therapist operating the tracheal suction catheter is directly exposed to the patient..Nanosecond Laser Cell Lysis in Microfluidic DevicesBackground: To date, cell lysis in microfluidic devices for analytical purposes has been achieved using chemical, electrical, and optical means. Chemical cell lysis occurs on time scales of several t..Methods of Manufacturing Microdevices in Laminates, Lead Frames, Packages, and Printed Circuit BoardsBackground: Microelectrical-mechanical systems (MEMS) are miniature mechanical devices intended to perform non-electronic functions such as sensing or actuation. These devices are typically built fro..Rescanning Laser Scanning Confocal MicroscopeBackground: The laser scanning confocal microscope (LSCM) is widely used as a confocal microscopy technique for imaging fluorescent objects in a manner that removes out of focus fluorescent light and..Optimizing Sound to Suppress TinnitusBackground: Tinnitus is the perception of sound in the absence of corresponding external sounds. Although known for its high-pitched ringing, tinnitus is an internal noise that varies in pitch and fr..Construction of Single Molecule Electronic Devices, with Applications to BiosensingBackground: "Molecular Electronics" (ME) generally refers to a class of novel electronic devices in which the electronic response and function are entirely controlled by single molecules. In principl..Prokineticin 2 and Prokineticin Receptor 2 as a Target to Treat Epilepsy and SeizuresBackground: PK2 belongs to a family of secreted peptides that regulate diverse biological functions including serving as a regulatory molecule for circadian rhythms. The signaling of PK2 is mediated ..Micromachined Passive Programmable Drug Delivery SystemsBackground: The ability to deliver drugs locally to the site of need and over a prolonged period of time is important as a therapeutic method for many ailments and diseases. Many drugs are more effec..Method and Apparatus for Performing Qualitative and Quantitative Analysis of Produce (Fruit, Vegetables) Using Spatially Structured IlluminationBackground: The use of wide-field, broadband, spatially illuminated imaging of turbid media has the potential for simultaneous surface and sub-surface mapping of media structure, function and composi..High Sensitivity Optical Coherence TomographyBackground: Optical coherence tomography (OCT) is a non-invasive sub-surface optical imaging modality with high axial resolution and high signal to noise ratio compared to other imaging modalities su..A New Mouse Model of Sjogren's SyndromeBackground: Sjogren's Syndrome is a grave autoimmune disease in which destruction of the exocrine glands leads to severe dryness of the eyes and mouth, with additional systemic complications. The pat..THE ARHGAP18 GENE AND SCHIZOPHRENIABackground: Correlation of brain images and genotypes for diagnostics of neuropsychiatric disorders and drug discovery Technology: The invention includes general methods for identifying markers th..Beta-Amyloid and Neurofibriallary Tangle Imaging AgentsBackground: Positron emission tomography (PET) is a non-invasive test that helps doctors diagnose abnormalities, determine the extent of disease, prescribe treatment, and track progress. The patient ..Dynamic Skin Cooling with Non-Toxic Cryogen with Minimal Global Warming PotentialBackground: An important issue in laser treatment of cutaneous lesions is to protect the epidermis from thermal damage. This heating, which is primarily caused by light absorption in the melanosomes,..Restoring Cough Using MicrostimulatorsBackground: Respiratory complications are the most common cause of morbidity and mortality following spinal cord injury. Patients with such injuries often suffer a disruption in the neuromuscular cen..Integrated Direct Electron Imaging SensorsBackground: Conventional charged particle imaging sensors use film and charged couple device (CCD). CCD has poor radiation tolerance and records images indirectly while the film is an analog recorder..Gene Encoding CRAC ChannelBackground: CRAC stands for Ca2+-Release Activated Ca2+. When Ca2+ from the endoplasmic reticulum (a major store of Ca2+) is depleted, a CRAC channel, is activated to slowly replenish the endoplasmic..CAP/SORBS1 Gene and DiabetesBackground: Diabetes Mellitus (DM) is one of the leading causes of death in the United States (Bassett). The molecular defects underlying the development of most human Type 2 DM are not yet clear. Bu..Flexible Endoscopic TubeBackground: In performing, through an anatomical channel inside the body, a diagnostic or surgical procedure, the surgeon or operator may need to rotate with precision the distal end inside the body,..Intragastric Balloon for Treatment of ObesityBackground: The BioEnterics Intragastric Balloon System™ is a non-surgical, non-pharmaceutical alternative for the treatment of obesity. The balloon system is designed to provide loss therapy to re..Microfluidic Device for Forming Monodisperse LipoplexesBackground: The determinant factor for the successful applications of delivering drugs is to develop a non-viral and efficient carrier. Cationic lipid based liposomal carriers are the most attractive..Technique to Characterize NIitric Oxide Exchange in the LungsBackground: It has been reported that the concentration of Nitric oxide (NO) in the exhaled breath was substantially elevated in patients with asthma who were not treated with corticosteroids, sugges..Methodology of Elasto-MammographyBackground: It has been well recognized that the tissue stiffness plays an important role for diagnosis of breast cancers, as tumors are stiffer than the surrounding breast tissues, and malignant tum..Methodology of Elasto-MammographyBackground: It has been well recognized that the tissue stiffness plays an important role for diagnosis of breast cancers, as tumors are stiffer than the surrounding breast tissues, and malignant tum..A Novel 7 Base Deletion in the Gene on Chromosome 21 for Diagnostic of KeratoconusBackground: Keratoconus is a noninflammatory progressive corneal thinning disorder leading to mixed myopic and irregular astigmatism and is implicated as a major cause of cornea transplants in the We..Wafer Scale Glass BlowingBackground: Large scale confinement chambers have been created in the past using traditional glass-blowing techniques. However, conventional glass-blowing can only be used to create large components ..An Integrated Microfluidic Platform with Lateral Dielectrophoresis (DEP) Based Cell/Particle SeparationBackground: Most of the current techniques used for Dielectrophoresis separation use planar electrodes which sit at the bottom of the channel. With this design the electric field decreases dramatical..Protein Nanocapsule for Drug DeliveryTechnology: University of California researchers are investigating a protein scaffold system for molecular transport, namely, the E2 protein of Bacillus stearothermophilus in the pyruvate dehydrogena..Hybrid Binding Proteins Against Pathological Protein Aggregates in the CentralBackground: The pathological protein aggregates such as beta-amyloids, alpha-synuclein and prion protein deposits in the CNS can be removed by vaccination, i.e., immunization using specific antibodie..Wafer-Level Micro-Glass BlowingBackground: Large scale confinement chambers have been created in the past using traditional glass-blowing techniques. However, conventional glass-blowing can only be used to create large components ..Generation of Stable Concentration Gradients in 2D and 3D Environments Using a Microfluidic Ladder ChamberBackground: In the chemical, biomedical, and pharmaceutical industries, it has become increasingly desirable to perform large numbers of chemical operations in a highly parallel fashion. For example,..Development of Diagnostics and Therapeutics for Cornelia de Lange SyndromeBackground: Cornelia de Lange Syndrome (CdLS) is a moderately common multisystem birth defects disorder that poses severe medical and social challenges for affected children and their families. Diagn..Methods and Reagents for Screening New Drugs and Treating Ion Pump Associated DisordersBackground: Sodium/potassium ATPases (Na+/K+-ATPases), a family of multi-subunit ion pumps, are the most important active transporters in animal cells. They are required for maintaining the electroch..Fabrication of Renewable RNA Microarrays and MethodsBackground: Numerous methods and devices are available to detect and/or quantify target DNA in a test sample. In almost all of these methods, detection and/or quantification are performed utilizing a..A Microfluidic Device for Enabling the Controlled Growth of Cells and Methods Relating to SameBackground: In many neurodegenerative diseases and in spinal cord injury, axons and synapses are damaged; a cell culture model is useful for investigation into these areas of research. In typical cel..Biomarker-Guided Prediction of Patient Adherence to MedicationsBackground: Adherence is one of the pivotal determinants of treatment outcomes for many medical disorders. It is estimated that 50% or more of patients with chronic conditions are noncompliant with m..LEF-1 Internal Ribosome Entry SiteBackground: Full length Lymphoid Enhancer Factor-1 (LEF-1) is a transcription factor that promotes cell growth via its interaction with the WNT signaling mediator beta-catenin. Truncated LEF-1 lacks ..Purification of Laminin 5Background: Lamin-5, a protein produced by skin, mammary and other epithelial cells, may be involved in the progression of cancer. Purified human laminin-5 is not commercially available, and we have ..Microfluidic Production of Monodispersed Submicron EmulsionsThrough Filtration and Sorting of Satellite DropsBackground: In the past decade, droplets have been intensively used by the industries as an agent for drug preparations, for plastic polymerizations, and chemical processing. Recent advancements in m..New Therapy to Inhibit Plasma Cells in Autoimmune DiseasesBackground: In patients suffering from multiple sclerosis (MS) B cells, stimulated by axon antigens, infiltrate central nervous system. Technology: The inventors discovered a new class of antibodi..Medical SpectroscopyDOMAIN Aging of injuries on a victim’s body is an important aspect of forensic medicine. Currently, visual assessment and colorimetry based on empirical criteria are the most common techniques for t..Diagnosis and prognosis of cancers in GI tractDOMAIN Although the incidence of gastric carcinoma (tumour in stomach) is declining, this disease is still the second most frequent cause of cancer death worldwide. Gastric carcinomas are often not de..Alginate - Drug Delivery SystemDOMAIN The mucosal surfaces of the body (such as GI tract, respiratory tract, eye, and genitourinary tract) constitute the major target for drug and gene delivery. As such, mucous secretions can have ..Rapid prediction of gene expression levels using spectroscopyDOMAIN The study of gene expression in cells is increasingly being used to understand their biological function. The genes are up- and down-regulated by a complex protein regulatory network, which res..A Microfabrication Process for Vertical Microelectrodes inside Polymer MicrochannelsBackground: For microfluidic applications, different electrodes inside the microfluidic channels may be patterned by metal evaporation methods such as thermal evaporation, electric beam evaporation, ..Wall-Less Microfluidics with On-Site Magnetohydrodynamic (MHD) Pumps for Continuous Flow ControlBackground: A disadvantage of closed microfluidic channels are that they are made from different materials. Also, most of the microchannels are fabricated from lithography techniques which require th..Optimal selection of flurophores for bioimaging using hyperspectral camerasDOMAIN In many situations it would be beneficial to have an instrument that can show In biology and medicine, fluorescent labelling is used to detect the location and concentration of various molecule..Real time hyperspectral imagingIn many situations it would be beneficial to have an instrument that can show directly the spatial distribution of various chemical components in real time of a surface. Typical application areas are ..Fiber optic bundle based optical coherence tomographyBackground: Optical coherence tomography (OCT) has been used for high resolution optical imaging in many areas of medicine, especially ophthalmology. "Conventional wisdom" was that OCT could not be d..ThirdEye – early detection of cerebral palsy (CP)DOMAIN An early and accurate detection of cerebral palsy (CP) enables correct treatment at an early age to the infant at risk. Today’s methods for detecting CP are unable to establish a diagnosis un..Methods and Compostions for the Treatment of Immune Disorders and Regulation of Cytokine and Growth Factor SignalingCategories: Pharmaceuticals: Central Nervous System Disorders, Immune and Inflammatory Disorders Biotechnology: Assays, Diagnostics, Model Systems Background: Mgat5 is an enzyme that glycosylat..MEMRI (manganese enhanced MRI)DOMAIN Within an ageing population, ischemic heart disease (IHD) and secondary heart failure represent major challenges underlining a demand for diagnostic imaging to identify IHD in its different sta..Phage-displayed Peptide Library with Affinity for Bacterial Elongation Factor TuBackground: The highly abundant GTP binding protein elongation factor Tu (EF-Tu) fulfills multiple roles in bacterial protein biosynthesis. EF-Tu also binds other ligands, including four structurally..High Density Micromachined Electrode Arrays Usable for Auditory Nerve Implants and Related MethodsBackground: Auditory prostheses using microelectrode arrays suffer from a number of limitations. Issues that were not resolved are electrode size, the need for electrical wires to communicate with an..Determining leakage through a heart valveDetermining the severity of a leakage through a heart valve is important. There are several parameters that are clinically interesting in this regard: the area of the lesion, the flow or flow rate thr..Glycosylase enzymesDOMAIN Glycosylases have found use in a number of methods aimed at analyzing DNA for the presence of altered nucleobases that could result from ionizing radiation or chemical oxidants, identifying mis..Method and Apparatus of Using 3D Conductive Structures in Dielectrophoretic Separation ApplicationsBackground: Researchers estimate that 80% of all machine failures are due to wear and that 1.3~1.6% of the GNP is lost to degradation of machinery due to friction-related wear. The abnormal abrasive ..Rapid Bio-Molecules Detection by Adjacent Impedance Probing (AIP) TechniquesBackground: Today, most detection schemes for DNA, proteins and other large biomolecules involve luminescent measurements using a variety of labels (i.e. fluorescent and/or chemiluminescent probes, p..Fabrication of Suspended Carbon Micro and Nano-scale StructuresRecent attention has focused on high aspect ratio carbon micro-electromechanical (C-MEMS) because of the many applications possible, such as micro-electrodes in electromechanical sensors and miniaturi..Method to Characterize Exhaled Nitric Oxide from the Airways Using a Sequence of Breathhold ManeuversBackground: Exhaled nitric oxide (NO) arises from both airway and alveolar regions of the lungs, which provides an opportunity to characterize region-specific inflammation. Current methodologies rely..Total Ankle ArthroplastyBackground: Total ankle arthroplasty (TAA) is the process of replacing a diseased ankle with a prosthetic ankle. Over the years there have been several efforts to provide a total ankle replacement sol..Methods for Assessing the Temperature of Deep Tissue in vivo Using Non-ionizing RadiationBackground: Measuring temperature in tissue is highly relevant to treatments applied to tissue in which the tissue becomes heated. This includes methods that treat tissue with RF (Radio Frequency) su..Microscope Immersion Fluid ApplicatorBackground: Microscopy is an important tool used by all researchers in the scientific community. Often, a microscope user will first scan the specimen with a low power dry objective and then wish to ..A New Tandem-Affinity Tag for Two-Step Protein Purification under Fully Denaturing ConditionsBackground: Preservation of posttranslational modifications during purification is crucial for successful mass spectrometric analyses of protein modifications. Current tandem-affinity purification st..TRANSGENIC MOUSE MODEL FOR SCREENING ANALGESIC AGENTSBackground: UC Case No.: 2004-692 Patent Application Publication No.: WO/2006/017293 International Application No.: PCT/US2005/024697 This invention is an animal model and various cell-based mode..New Polymeric BiomaterialsTechnology: The invention is on new polymeric biomaterials. The new biomaterials were created by chemical synthesis with carbohydrates and amino acids as building blocks. The biopolymers have a speci..Cell Encapsulation on a Microfluidic PlatformBackground: Cell encapsulation is a highly useful tool in cell culturing, assay, and cell-based therapy applications. Encapsulation has traditionally been accomplished by extrusion through a nozzle, ..A Diffusive Probe for Quantification of Optical Properties of Superficial LayersBackground: Diffuse optical spectroscopy (DOS) has been successfully employed for quantitative determination of in vivo optical properties and chromophore concentrations of deep tissues such as breas..Use of Laser-Induced Fluorescence for Determination of Root Canal Pathology and Localization of Pathological Tissues to Facilitate Endodontic TherapyBackground: Currently endodontic therapy is based upon radiographic information and tactile feedback. Direct detection and localization of infected dentin and pupal tissue has not been possible. It h..Nrf1 Deficient Mice as a Model for Liver Cancer and Non-Alcoholic SteatohepatitisBackground: Antioxidant and xenobiotic metabolizing enzymes are critical in the protection against chemically induced oxidative/electrophilic stress in cells that cause damage, DNA mutation, apoptosi..Invention of New Dendritic AmphiphilesBackground: Amphiphilic compounds are of general interest in numerous disciplines in life sciences, especially in pharmacology and general chemistry, and numerous amphiphilic compounds are known in t..Regulated Growth Factor Delivery for Nerve RegenerationBackground: Options for successful repair of peripheral nerves after traumatic injury remain suboptimal. Current strategies are limited to transfer of donor nerves from functional areas, with substan..Automatic Detection and Diagnostics of Diabetic RetinopathyBackground: Diabetes is a condition that affects blood vessels throughout the body, particularly in the kidneys and eyes. Diabetic retinopathy is a complication of diabetes and is the leading cause o..A Microfluidic Dynamic Vapor Control SystemBackground: Controlling the chemistry of small drops is troublesome owing to the difficulty in handling and metering small volumes. To change the chemistry of a 50nl drop by 10% would require adding ..Polymeric Valves for Controlled Drug DeliveryBackground: Biochips can be used in vitro or in vivo to deliver small, controlled amounts of chemicals or other molecules at controlled times and rates. Current delivery release mechanisms include el..Methods for Treating Port Wine Stain Birth Marks, Hemangiomas and Other Conditions Caused By Aberrant Blood VesselsBackground: Cutaneous vascular lesions including port wine stains (PWS) and hemangiomas are frequently treated with laser and light devices. The pulsed dye laser (PDL) is the current standard means o..Neuropeptide S (NPS) as a Treatment for Anxiety, Sleep Disorders, Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder, and AsthmaBackground: Patent "WO02/31145" discloses a newly deorphanized GPCR system, Neuropeptide S (NPS), the endogenous ligand, and its cognate GPCR. However this patent does not detail the pharmacological ..Method for Quantitative Digital Color Imaging of ObjectsBackground: In many disciplines, quantitative measurements of color are required to evaluate nondestructively the state of an object (e.g., quality of produce). This characterization is typically per..High-Isolation Tunable MEMS Capacitive SwitchBackground: For a typical MEMS switch, the resonant frequency is around 20 to 30 GHz which can not be employed by commercial wireless systems operating at a frequency band of 2 to 8 GHz. This resonan..Reagents and Methods for Diagnosis of Attention Deficit Hyperactivity DisorderBackground: Attention Deficit Hyperactivity Disorder (ADHD) is the most prevalent disorder of early childhood. It affects an estimated 3-6% of elementary school children. ADHD consists of development..Microfluidic Devices for Controlled Viscous Shearing and Formation of Amphiphilic VesiclesBackground: Amphiphilic vesicles are artificial cells with applications in drug delivery (including biomolecular nanomedicine such as DNA, peptides, proteins), combinatorial chemistry, nanoscale chem..An Antibody-based Method for Reducing Ocular Inflammation Which Can Aid in Corneal TransplantationHSV keratinitis is characterized, in part, by scarring of the eye as a result of HSV reactivation. To date, corneal transplantation is the standard treatment method. A significant obstacle preventing ..A New Burr DesignBackground: One of the great limitations in spine surgery is the difficulty with removing bone without damaging adjacent soft structures (such as the spinal cord, nerves, and durra). This difficulty ..New Clinical Bymixer for Fast-Response, Adjustable Measurement of Mixed Expired Gas Fractions in the Anesthesia Circle CircuitBackground: The volume of O2 consumption (VO2) and the volume of CO2 production (VCO2) can give vital information about a patient under anesthesia. For example, monitoring VO2 can detect non-steady s..Novel, Stand-alone, Closed Ventilating Circle Circuit with CO2 Absorption and Sensitive Spirometry Measures Pulmonary O2 Uptake During AnesthesiaBackground: The volume of O2 consumption (VO2) and the volume of CO2 production (VCO2) can give vital information about a patient under anesthesia. For example, monitoring VO2 can detect non-steady s..High-Resolution X-Ray Crystal Structures of Tritrichomonas Foetus Inosine Monophosphate Dehydrogenase as Lead Compound for Structure-Based Drug DesignBackground: Trichomoniasis is a venereal disease of cattle caused by a protozoan parasite, Tritrichomonas foetus. The disease has been reported worldwide with an estimated economic loss to the U.S. b..A Polymeric Micro-Cantilever Resonator Array and Its Implications in Auditory ProsthesesBackground: Ten percent of the general population suffers from hearing loss and that number rises to thirty five percent for people over sixty-five years of age. However, current digital hearing aids..Selective Inhibition of Enzyme Isoforms of Nitric Oxide SynthetaseUniversity of California, Irvine researchers have discovered a method to design and use selective inhibitors against a family of nitric oxide synthetase isoforms that control the production of nitric ..Methods for Assessing the Condition of Bone In-Vivo Using Non-Ionizing RadiationBackground: The ability to assess the health and condition of bone tissue is important since bone tissue viability is closely linked to composition, structure, and physiology. Traditional methods for..Vascularized Artificial TissueBackground: There exists a need for thick artificial tissues to cover large tissue defects following trauma or surgical resection of tumor. The primary limitation in the design of these tissues as we..hKCa3/KCNN3 Calcium Activated Potassium Channel: A Diagnostic Marker and Therapeutic Target for Heritable, Neurological and Psychiatric DiseasesUniversity of California, Irvine researchers have discovered SKCa3-1b and SKCa3-1c, two novel isoform variants of the SK3 (also known as KCNN3) gene. The SK3 gene is located on human chromosome 1q21 i..Novel Cytodiagnostic Markers For CancerBackground: Cervical cancer is one of the leading causes of cancer-related death in women worldwide. Approximately 500,000 new cases are diagnosed each year and pre-cancerous abnormalities of the cer..Wnt, Fz, and BMP-6 Receptors for the Treatment and Detection of Colon CancerBackground: Ectopic activation of the Wnt signaling pathway leads to increased cellular growth and division in experimental organisms and mutations in the Wnt pathway. Wnt pathway genes are tightly l..Platelet Aggregation InhibitorsThrombin is an enzyme in the blood that plays a key role in platelet formation during injury. While blood coagulation is essential for a surface wound, platelet activation underlies various pathologic..ADP Glucose Receptor as a Target for Disorders Involving Platelet AggregationBackground: Recently, activation of the P2Y12 G-protein coupled receptor (GPCRs) has been shown to be central to platelet aggregation. Drugs preventing platelet aggregation are being tested, but one ..A New Process Of Adding Alkyl Groups To Organic Substrates Using TmI2(MeOCH2CH2OMe)3Background: In the pharmaceutical industry, synthetic chemists often alkylate starting compounds to generate compounds that have more desirable properties. However, the current reagents used in this ..Use Of Infectious And Pathogenic Clone Of A Lung Cancer-Inducing Retrovirus For Generation Of Therapeutic Reagents And Diagnostic TestsBackground: Jaagsiekte sheep retrovirus (JSRV) causes broncheolo-alveolar carcinoma in sheep and is a significant veterinary problem world-wide. Clinically and histopathologically, this disease has s..Donor Organ Preservation for Transplantation Using a Hemoglobin Based SolutionDuring heart transplantation, the heart must be preserved while it is transported from donor to recipient. Standard techniques call for the heart to be immersed and cooled in cardioplegia or saline so..Modulation Of Cell Growth And Growth Factor Signaling Through Removal Of GlypicansBackground: Membrane associated heparin sulfate proteoglycans (HSPGs) have been shown to play important roles in many aspects of cell behavior, including cell-cell and cell-extracellular matrix adhes..Novel And Selective Inhibitors Of HIV-1 IntegraseIn the ongoing battle against the human immunodeficiency virus (HIV), researchers at the University of California, Irvine, have synthesized novel compounds that inhibit the protein HIV Integrase and p..Diagnostic Marker And Novel Therapeutic Target For Neurodegenerative DisordersScientists at the University of California, Irvine, have isolated a candidate gene that may be responsible for increasing the risk of schizophrenia and bipolar disorder. This elusive gene encodes for ..Enhancement Of Host Defense Via Receptor(s) For C1qBackground: As the development of protein products and peptide mimetics becomes more prevalent in the biotechnology and pharmaceutical industries, the ability to mimic the protective and modulate the..Humidity And Temperature Sensor Device For The Determination Of Oxygen Consumption In Medical ApplicationsBackground: The determination of oxygen consumption is an important monitor of normal cardiopulmonary and tissue function in anesthesia and critical care medicine. This requires accurate measurement ..A New Polymerization Method For PolymethyleneBackground: The most common method for manufacturing polyolefins and their derivatives is by polymerization of olefin monomers with Ziegler-Natta catalysts or by the use of free radical, nucleophilic..Transgenic Animal Models For Alzheimer's DiseaseThe present invention provides non-human, transgenic animals for use as a model for the study of Alzheimer's Disease. The animals exhibit pathology associated with Alzheimer's Disease. The phenotype i..Isolation Of Biological MaterialsCurrently, flow cytometry is the only method available for the purification of specific chromosomes. The current flow cytometry method requires a long time to sort large quantities of cellular sta..Method Of Inhibiting The Transport Of L-glutamateBackground: L-Glutamate is one of the most abundant excitatory neurotransmitters in the mammalian brain and, as such, is responsible for many synaptic transmissions in the central nervous system. Yet..Assay For And Treatment Of Autoimmune DiseaseThe invention is directed to prognosis, diagnosis and treatment of autoimmune diseases, including SLE (systemic lupus erythematosus), type-1 diabetes, experimental allergic encephalomyelitis (EAE) and..Position-Specific Insertion Vectors And Method Of Using SameBackground: Retrovirus vectors infect cells at high efficiency and are capable of integrating DNA copies of themselves into a host genome. Such vectors are, in many ways, desirable for introduction a..Biomimetic Agents for Replacement of NAD+/NADH in Enzymatic ReactionsAPPLICATION OF TECHNOLOGY: - Preparation of chiral, pharmaceuticals, or specialty organic compounds - Biosensor technology for medical, chemical and biological sensing ADVANTAGES: - Co-factors ar..Berkeley Ergonomic ArmBerkeley Ergonomic Arm is a practical ergonomic intervention and support system to improve productivity and reduce work place ergonomic-related injuries. Berkeley Ergonomic Arm dynamically enhances mu..Apolipoprotein A-1 Variants for Reducing Cardiovascular-Related RisksSingle dose drug therapy for preventing restenosis and reducing the effects of acute phase response ADVANTAGES: - Promises to help prevent restenosis and thereby reduce the frequency of repeated i..Antibodies for Monitoring and Phosphorylation Sites for Inhibiting DNA Double-Strand Break RepairAPPLICATIONS OF TECHNOLOGY: - Developing therapeutics for the radiosensitization of cancer cells - Assessing the efficacy of cancer treatments - Cancer drug screening and development - Research on t..An Apolipoprotein that Strongly Modulates Plasma Triglyceride LevelsAPPLICATIONS OF TECHNOLOGY: - Creation of new lipid-reducing drugs - Large scale genetic screening of individuals for cardiovascular disease susceptibility - Delivery of the ApoAV protein to reduce ..Aligned Crystal Growth at Polymerized MembranesAPPLICATIONS OF TECHNOLOGY: - Semiconductor crystals - Magnetic materials ADVANTAGES: Low-cost, low-energy method works at room temperature ABSTRACT: LBNL researchers, Deborah Charych and Ami..Assays Based on the Role of Dystroglycan and Alpha-Dystroglycan Proteolysis in Tumor Cell GrowthPATENT SUMMARY: The present invention relates to methods and compositions for the diagnosis and treatment of cells lacking normal growth arresting characteristics. This characteristic is referred to ..Using Novel Enzymes To Produce Advanced BiofuelsAPPLICATIONS OF TECHNOLOGY: Biosynthesis of carboxylic acids and lactones for biofuel production ADVANTAGES: - Provides biofuel alternatives to ethanol - The new enzymes can be modified to tailor..Low-resistivity Photon-transparent Window Attached to Photo-sensitive Silicon DetectorAVAILABLE TECHNOLOGIES Low-resistivity Photon-transparent Window Attached to Photo-sensitive Silicon Detector APPLICATION OF TECHNOLOGY: - Medical Imaging - Other Digital Scanning technologies ..High Quantum Efficiency Charge-Coupled DeviceAPPLICATIONS OF TECHNOLOGY: Low-level light imaging (Astronomical research, Raman Spectroscopy) ADVANTAGES: - Back illuminated - High near-IR quantum efficiency without fringing - Excellent broad..Genes Encoding Telomere-Associated ProteinsAPPLICATIONS OF TECHNOLOGY: - Molecular biology research - Medical research ABSTRACT: Telomeres are believed to be critical regulators of the genome, and telomere stability important for preventin..Full Karyotype Analysis for Increasing Pregnancy Rates per IVF CycleAPPLICATIONS OF TECHNOLOGY: - Screening all 24 chromosomes for numeric chromosome abnormalities during Preimplantation Genetic Diagnosis - Diagnosing disease states requiring cytogenetic analysis - M..Fast Scintillation Detectors Using Direct-Gap SemiconductorsAPPLICATION OF TECHNOLOGY: - Detection of ionizing radiation (e.g. x-rays, gamma rays, neutrons) - Nuclear materials detection - Nondestructive materials evaluation - Nuclear medical imaging - Elect..Comprehensive Prognostic Markers and Therapeutic Targets for Drug-Resistant Breast CancersAPPLICATIONS OF TECHNOLOGY: Under a microscope, fluorescent markers (right) reveal amplified genes in the chromosomes of a breast tumor’s cells. - Identifying patients with breast cancers that a..Color and Shape Changing Polymeric Ribbons and SheetsPATENT APPLICATION ABSTRACT: The present invention provides the design, synthesis and characterization of compositions comprising asymmetric bolaamphiphilic lipids that form extended polymeric ribbon..Electrospray Emitters for Integrating Mass Spectrometry with Microfluidic DevicesAPPLICATIONS OF TECHNOLOGY: - Multinozzle electrospray emitters for proteome-on-a-chip - Mass spectroscopy of peptides and biomolecules with a wide range of weights - Process for fabricating comp..Termite Microbial Enzymes for Energy Efficient Biofuel ProductionAPPLICATIONS OF TECHNOLOGY: Converting plant lignocellulosic biomass to simple sugars for fermentation into biofuels, and hydrogen. ADVANTAGES: - Promises to be more energy and chemically efficie..High Efficiency Micro-Scale Light-Concentrating Arrays for Digital ImagingIB-2279 APPLICATIONS OF TECHNOLOGY: • Digital imaging • Digital cameras, image scanners, and pixelated detectors • Applicable to visible, ultraviolet and infrared cameras ADVANTAGES: ..Co-registration of PET and Transrectal Ultrasounds (TRUS) Images for Improved Prostate Imaging and BiopsyIB-2420 Dual PET-TRUS imaging co-registers positron emission tomography and transrectal ultrasound images taken during the same patient exam. The simulated “merged PET-TRUS image” (central imag..SATB1: A Fundamental Prognostic Marker and Therpeutic Target for Metastatic Breast CancerIB-2186 Published in Nature, March 2008. See link below. APPLICATIONS OF TECHNOLOGY: Screening for metastatic-prone breast cancers Using SATB1-specific inhibitors to treat breast cancer ..Non-Transgenic Cell Lines for Identifying Target Premalignant GenesIB-2023 Berkeley Lab's S3 cell lines display partial loss of differentiation in 3DirBM Cultures. Human breast epithelial cell lines were derived from a patient with fibrocystic breast dise..Method for Identifying New Breast Cancer Stem Cells and Targeted TherapiesJIB-2395 APPLICATIONS OF TECHNOLOGY: Development of new breast cancer therapies and diagnostic assays Researching cancer progression and remission ADVANTAGES: Specifically isolates human mamm..Electrostatic-based DNA Microarray TechniqueJIB-2397 Press Release, Berkeley Lab, June 30, 2008 The dream of personalized medicine — in which diagnostics, risk predictions and treatment decisions are based on a patient's genetic profil..Using Novel Enzymes To Produce Advanced BiofuelsEJIB-2540 APPLICATIONS OF TECHNOLOGY: Biosynthesis of carboxylic acids and lactones for biofuel production ADVANTAGES: Provides biofuel alternatives to ethanol The new enzymes can be modi..Altering Bone Density by Modulating SOST Expression via Tissue-specific EnhancersB-1944 APPLICATIONS OF TECHNOLOGY: Developing therapies for treating bone related conditions such as osteopenia, osteoporosis, fractures, and sclerosteosis Diagnosing and treating Van Buchem’..Gram Positive and Gram Negative PlasmidAbstract The present invention provides a bacterium containing a unique plasmid. The plasmid is unique in its ability to replicate in both Gram positive and Gram negative bacteria. In addition, the ..Synthesis of Colloidal Upconverting Monodisperse Nanocrystals for Biological ApplicationsDescription of the technology: Synthesis, characterization, and spectroscopy of upconverting lanthanide-doped NaYF4 nanocrystals (NCs). Monodisperse cubic NaYF4 NCs were synthesized via a thermal dec..Silica NanoboxesMicroporous crystalline materials (e.g. zeolites, aluminophosphates), also called molecular sieves, are widely used as catalysts, adsorbents, and membranes. Two factors largely determine the utility o..74.1, Vertebrate Cytoplasmic DyneinThis monoclonal antibody is for one of the polypeptides of vertebrate cytoplasmic dynein. This antibody is an IgG and is therefore more useful than IgM; it is also prepared with mammal (cow) antigen, ..Method and Apparatus for Monitoring and Restoration of Shunt FunctionGeneral Information Hydrocephalus is a condition where cerebrospinal fluid (CSF) in the brain accumulates in the ventricles and increases pressure within the skull. It is routinely treated through ..Liquid-phase Reactor for Catalytic Production of Biomarkers from Biological MaterialsLiquid-phase Reactor for Catalytic Production of Biomarkers from Biological Materials - A method for rapid identification of biological materials such as Anthrax. General Information In 2001, just..Notify me of New Entries on this PageYou can receive an email whenever a new technology for sale is added to this category. You can unsubscribe at any time. |
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