Method of Synthesizing Acetonide-Protected Catechol-Containing Compounds and Intermediates Produced Therein

The inventors disclose here a novel, facile approach to the synthesis of acetonide-protected catechol-containing compounds having at least one amine group. In specific embodiments, the invention provides novel methods of synthesizing 3,4-dihydroxyphenylalanine (H-DOPA(acetonide)-OH (6)), Fmoc-protected H-DOPA(acetonide)-OH (Fmoc-DOPA(acetonide)-OH (7)), Fmoc-protected dopamine (Fmoc-dopamine(acetonide) (10)), TFA-protected dopamine (TFA-dopamine(acetonide) (13)) and acetonide-protected 4-(2-aminoethyl)benzene-1,2-diol (acetonide-protected dopamine (14)).

Patents:
US 20,100,087,622

Inventor(s): MESSERSMITH PHILLIP B [US]; HU BI-HUANG [US]; LIU ZHONGQIANG [US]

Type of Offer: Licensing



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