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Chemistry Technologies for Sale or License

The following are Chemistry technologies offered for sale or license. Viewing technologies for sale is a free service of IdeaConnection.com, as is connecting with the seller if a technology interests you. Click on a heading below for more information.

Chemistry is the science of the physical, structural, and compositional properties of matter, and their chemical reactions. The physical components of chemistry include atoms, molecules, crystals. Many areas of science fall under the umbrella of chemistry such as physical, organic, inorganic, and biochemistry. Post your business technology for sale or license here.

COMPOSITIONS AND METHODS FOR INHIBITING SPHINGOSINE KINASE

Amidine analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumor cells.

BICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS

Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.

ALKYNES AND METHODS OF REACTING ALKYNES WITH 1,3-DIPOLE-FUNCTIONAL COMPOUNDS

1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic ..

SYNTHETIC LIPID A DERIVATIVE

The invention provides functionalized monosaccharides and disaccharides suitable for use in synthesizing a lipid A derivative, as well as methods for synthesizing and using a synthetic lipid A derivat..

Synthesis and Stabilization of Neutral Compounds with Homonuclear Bonds

The present invention is directed to the synthesis and stabilization of neutral molecules containing homonuclear single or multiple bonds, methods of preparation, and uses thereof.

PHOSPHORESCENT COMPOSITIONS, METHODS OF MAKING THE COMPOSITIONS, AND METHODS OF USING THE COMPOSITIONS

Compositions, methods of making compositions, materials including compositions, crayons including compositions, paint including compositions, ink including compositions, waxes including compositions, ..

Microbial production of alanine

Microbial production of pyruvate and metabolites derived from pyruvate in cells exhibiting reduced pyruvate dehydrogenase activity compared to wildtype cells. Acetate and glucose are supplied as a car..

PREPARATION OF ALKENES BY MILD THERMOLYSIS OF SULFOXIDES

Embodiments of this disclosure, among others, encompass methods for generating alkenes under mild thermolytic conditions that can provide almost total conversion of a precursor compound to an alkene w..

HEPARAN SULFATE SYNTHESIS

The invention provides an efficient modular chemical synthesis for heparan sulfate oligosaccharides based on orthogonal protection strategies. Modular disaccharide building blocks, themselves the prod..

MICROBIAL PRODUCTION OF PYRUVATE AND PYRUVATE DERIVATIVES

Microbial production of pyruvate and metabolites derived from pyruvate in cells exhibiting reduced pyruvate dehydrogenase activity compared to wild-type cells. Acetate and glucose are supplied as a ca..

NEAR INFRARED DOPED PHOSPHORS HAVING A ZINC, GERMANIUM, GALLATE MATRIX

Phosphors based on transition metal-activated gallates, particularly Cr3+- and Ni2+-activated zinc germanium gallates, are disclosed herein. In some embodiments such phosphors can exhibit persistent i..

NEAR INFRARED DOPED PHOSPHORS HAVING AN ALKALINE GALLATE MATRIX

Phosphors based on doping of an activator (an emitter) into a host matrix are disclosed herein. Such phosphors include alkaline gallate phosphors doped with Cr3+ or Ni2+ ions, which in some embodiment..

FLUORESCENT PROCHELATORS FOR CELLULAR IRON DETECTION

Fluorescent probe compound of Formula Ia or Formula Ib: are described, along with methods of using the same to detect iron, copper, and hydrogen peroxide.

METHODS AND COMPOSITIONS FOR PREDICTING SUCCESS IN ADDICTIVE SUBSTANCE CESSATION AND FOR PREDICTING A RISK OF ADDICTION

The present invention relates to genetic polymorphisms that are associated with dependence on an addictive substance. In particular, the present invention relates to a method for predicting success in..

METHODS AND COMPOSITIONS FOR IDENTIFYING INDIVIDUALS AT REDUCED RISK OF SEPSIS

The present invention provides a method of identifying a subject having a reduced risk of developing sepsis, comprising detecting at least one APOE3 allele in nucleic acid from the subject.

NICOTINIC ACID RECEPTOR LIGANDS

The present invention relates, in general, to nicotinic acid receptor ligands and, in particular, to ligands that have a relative efficacy for activating a G- protein-coupled receptor function (e.g., ..

ASYMMETRIC ALPHA FUNCTIONALIZATION AND ALPHA, ALPHA BISFUNCTIONALIZATION OF ALDEHYDES AND KETONES

The present invention relates, generally, to asymmetric a-functionalization and to asymmetric a,a-bisfunctionalization of ketones and aldehydes and, in particular, to chiral auxiliaries suitable for u..

Method for Distinguishing Follicular Thyroid Adenoma (FTA) From Follicular Thyroid Carcinoma (FTC)

Follicular thyroid adenoma (FTA) is distinguished from follicular thyroid carcinoma (FTC) by comparing amount of an expression product of at least one gene selected from the group consisting of DDIT3,..

Droplet-Based Surface Modification and Washing

The present invention relates to droplet-based surface modification and washing. According to one embodiment, a method of splitting a droplet is provided, the method including providing a droplet micr..

METHODS AND COMPOSITIONS FOR IDENTIFYING INHIBITORS OF MUTS-alpha OR MUTS-beta INTERACTION WITH MUTL-alpha

Disclosed are methods and kits for screening potential inhibitors of MutS[beta] by screening agents for the ability to selectively inhibit interaction between MutS[beta] and MutL[alpha]. Also disclose..

Reacting chemical compound by biotransformation, preferably whole cell biotransformation, useful for degrading environmental pollutant and producing chiral intermediate, comprises adding alginite as r

Reacting chemical compounds by biotransformation, preferably whole cell biotransformation, comprises adding alginite as reaction additive to the reaction medium.

Cleavage of esters, amides or thioesters of formic acid, comprises converting ester, amide or thioester of formic acid to carbon dioxide and corresponding alcohol, amine or thiol by a formate dehydrog

Cleavage of esters, amides or thioesters of formic acid, comprises converting ester, amide or thioester of formic acid to carbon dioxide and corresponding alcohol, amine or thiol by a formate dehydrog..

Distillation of ionic liquids

Process for the distillation of mixtures containing salts with a melting point below 200 ° C at 1 bar (ionic liquids) contained, characterized in that - contains the cation of ionic liquid, a heteroc..

Procedures and preparation of ionic liquids by anion

Process for the preparation of salts of formula I, (B +) nxAy-where B is a cation which contains at least one nitrogen atom, A is an anion and n is an integer from 1 to 3, x and y are whole numbers ar..

METHOD FOR PRODUCING CELLULOSE ACETALS

The present invention describes a method for producing acetals of poly-, oligo-or disaccharides by dissolving them in at least one ionic liquid and then reacting them with a vinylether. The resulting ..

PROCESS FOR SILYLATING CELLULOSE

The present invention describes a process for silylating polysaccharides, oligosaccharides or disaccharides or derivatives thereof by dissolving these in an ionic liquid and reacting them with a silyl..

ACID CERAMIDASE POLYMORPHISMS AND METHODS OF PREDICTING TRAITS USING THE ACID CERAMIDASE POLYMORPHISMS

Provided are methods of predicting a trait in a subject including obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding the a..

Methods and apparatus for manipulating droplets by electrowetting- based techniques

An apparatus is provided for manipulating droplets. The apparatus is a single-sided electrode design in which all conductive elements are contained on one surface on which droplets are manipulated. An..

Droplet-Based Pyrosequencing

The present invention relates to droplet-based pyrosequencing including a method of identifying a base at a target position in a sample nucleic acid. The method includes: (a) providing a droplet micro..

C16 UNSATURATED FP-SELECTIVE PROSTAGLANDIN ANALOGUE

PROBLEM TO BE SOLVED: To provide a new PGF (prostaglandin F) analogue useful in treating various diseases and symptoms including bone disorders. ; SOLUTION: A compound having a structure in accordance..

DROPLET-BASED BIOCHEMISTRY

The present invention relates to a droplet microactuator and to systems, apparatuses and methods employing the droplet microactuator for executing various protocols using droplets. The invention inclu..

COBALT-CATALYZED ASYMMETRIC CYCLOPROPANATION WITH DIAZOSULFONES

Asymmetric cyclopropanation of olefins with diazosulfones.

ACYLSULFONAMIDES AND PROCESSES FOR PRODUCING THE SAME

The present disclosure relates to acylsulfonamides and processes for their preparation. The processes involve a target-guided synthesis approach, whereby a thioacid and a sulfonyl azide are reacted in..

TRIAZOLES AND PROCESSES FOR PRODUCING THE SAME

The present disclosure relates to triazoles and processes for their preparation. The processes involve a target-guided synthesis approach, whereby an alkyne and an azide are reacted in the presence of..

ENANTIOSELECTIVE RING-OPENING OF AZIRIDINES

A process for the preparation of a nucleophilic addition product of an aziridine and a nucleophile, the process comprising treating the arizidine with the nucleophile in the presence of a biaryl phosp..

COBALT-CATALYZED ASYMMETRIC CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS

Cobalt-catalyzed asymmetric cyclopropanation of electron-deficient olefins.

Supramolecular Assemblies and Building Blocks

The present invention generally relates to supramolecular assemblies and their modes of synthesis. The supramolecular assemblies include a 1:8 ratio of a supermolecular polyhedral building block and a..

PROTEASOME INHIBITORS HAVING CHYMOTRYPSIN-LIKE ACTIVITY

Disclosed herein is the use of HLM-008182, as well as its analogues formed via in-house synthesis, as a potent proteasome inhibitors. A new method was developed for HLM-008182 through a four-step prot..

ALKENE AZIRIDINATION

A process for the asymmetric aziridination of an alkene comprising treating the alkene with a sulfonyl azide, preferably trichloroethoxysulfonyl azide, in the presence of a cobalt(II) porphyrin.

ASYMMETRIC CYCLOPROPANATION WITH SUCCINIMIDYL DIAZOACETATE

Cobalt(ll) complexes of the D 2-symmetric chiral porphyrins are effective catalysts for asymmetric cyclopropanation reactions with succinimidyl diazoacetate. The Co-catalyzed reaction is suitable for ..

Cobalt-Catalyzed Asymmetric Cyclopropanation of Alkenes with alpha-Nitrodiazoacetates

A process for the cyclopropanation of olefins with a metal porphyrin catalyst and an acceptor/acceptor substituted diazo reagent.

ASYMMETRIC CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS WITH DIAZO REAGENTS

Cobalt-catalyzed asymmetric cyclopropanation of electron-deficient olefins.

IONIC LIQUID MEDIATED SOL-GEL SORBENTS

Ionic liquid (IL)-mediated sol-gel hybrid organic-inorganic materials present enormous potential for effective use in analytical microextraction. One obstacle to materializing this prospect arises fro..

Metal Porphyrin Catalyzed Olefin Aziridination with Sulfonyl Azides

Cobalt(II) complex of P1 [Co(P1)], a new porphyrin that was designed on the basis of potential hydrogen bonding interactions in the metal-nitrene intermediate, is a highly active catalyst for olefin a..

HETEROSUBSTITUTED N-THIOLATED BETA-LACTAM COMPOUNDS AND METHODS OF USE

The invention relates to heterosubstituted N-thiolated beta-lactams, compositions comprising these compounds, methods for their production, and methods of use as antibiotics to inhibit the growth of b..

SILICA-BASED MATERIAL FOR DETECTION AND ISOLATION OF CHITIN AND CHITIN-CONTAINING MICROORGANISMS

The subject invention provides silica-based material that has high affinity to chitin, chitin derivatives and chitin-containing microorganisms at an acidic pH. In an embodiment, the silica-based mater..

EGGSHELL CATALYST AND METHOD OF ITS PREPARATION

An eggshell catalyst useful for a Fischer-Tropsch (FT) synthesis or other reactions comprises a homogeneously dispersed transition metal and a promoter situated in an active phase in a precisely selec..

LIGHT CURING COMPOSITIONS

The present invention relates to light curing compositions, comprising radically polymerizable vinyl compounds and daylight sensitive radical initiators of the formula (I) and/or (II), and optionally ..

DEVICE FOR THE CONTINUOUS ANNULAR ELECTROCHROMATOGRAPHY

An annular gap apparatus (110) for performing a capillary electrochromatography is disclosed. The annular gap apparatus (110) has at least one separator (112) with at least one fixed annular gap (114)..

Catalyst systems comprising an alkaline earth metal chloride and their application for metathesis reactions

Catalyst system (I) comprising a metathesis catalyst containing a complex catalyst on basis of a 6th or 8th group metals and exhibits at least one carbene group at the metal bonded ligands, and an alk..

New ruthenium- and osmium-carbene-complex catalysts, which are bonded with chiral carbon atoms or over double bonds at a catalyst base skeleton, useful e.g. in metathesis-reactions, preferably in ring

Ruthenium- and osmium-carbene-complex catalysts (I), which are bonded with chiral carbon atoms or over one or more double bonds at a catalyst base skeleton, are new. Ruthenium- and osmium-carbene-comp..

CHELATING AGENT

A compound of the formula: wherein R<1> is selected from H, methyl, ethyl, carboxyl protecting groups and hydrophilic moieties, R<2> and R<3> are independently selected from H, methyl, ethyl and carbo..

Polycrystalline silicon thin layers produced by titanium-supported metal-induced layer exchange

The method involves applying a layer sequence on a substrate, where the layer sequence has an oxidation layer arranged between an output layer and an activator layer. The layer sequence is treated wit..

MULTILAYER SILK PROTEIN FILMS

The present invention is directed to a method of forming multilayer silk protein films and a multilayer film obtained therefrom. The invention is further directed to various materials, products and co..

USE OF PROKARYOTIC TIR-DOMAIN CONTAINING PROTEINS AS THERAPEUTIC AND DIAGNOSTIC AGENTS

The present invention relates inter alia to nucleic acid molecules encoding prokaryotic TIR-domain containing polypeptides as well as fragments and functional homologues thereof for diagnostic and the..

MUTEINS OF HNGAL AND RELATED PROTEINS WITH AFFINITY FOR A GIVEN TARGET

The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also relates to ..

POLYMERIC DELIVERY SYSTEMS FOR ACTIVE AGENTS

A composition, comprising: (a) at least one copolymer comprising repeating units of formula (I) wherein RA is a hydrocarbon group, optionally substituted with -OH, -SH, -COOH, NR'2, -COOR', -CONR', -C..

Mutated Abl kinase domains

The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequ..

NMP-CONTAINING EXTRACT, A METHOD OF ITS PRODUCTION AND USES THEREOF

The present invention relates to a N-methylpyridinium cation (NMP)-containing extract, a method for its production, uses of said NMP-containing extract as a dietary supplement and for the prevention o..

COMPOUNDS FOR NON-INVASIVE MEASUREMENT OF AGGREGATES OF AMYLOID PEPTIDES

The invention relates to the provision of compounds, methods for producing them, and their use for imaging and quantification of aggregates of ss-amyloid peptides in vivo. In a preferred aspect of the..

DEUTERIUM ISOBARIC TAG REAGENTS FOR QUANTITATIVE ANALYSIS

Deuterium isobaric tag reagents are provided for the quantitation of biomolecules, where the reagents contain heavy isotope atoms, including one or more 2H in each reagent. Generally, the reagents are..

CYCLOPENTADIENYLPHOSPHAZENE COMPLEXES (CpPN COMPLEXES) OF METALS OF THE THIRD AND FOURTH GROUP AND OF THE LANTHANOIDS

The present invention relates Cyclopentadienylphosphazen complexes (CPPN complexes) of Group III. and group IV and the lanthanides with the exception of lutetium. The novel complexes are too isolobal ..

NON-VIRAL TRANSFECTION AGENT

The invention relates to a non-viral transfection agent comprising polymer/nucleic acid complexes and nanofibers, wherein the polymer/nucleic acid complexes are composed of at least one nucleic acid a..

PROCESS FOR PREPARATION OF POLYOLEFINS VIA LIVING COORDINATIVE CHAIN TRANSFER POLYMERIZATION

Disclosed is a method of producing a polyolefin composition comprising contacting a metallocene pre-catalyst, co-catalyst, and a stoichiometric excess of a metal alkyl; adding a first olefin monomer; ..

Allylic Oxidations Catalyzed by Dirhodium Catalysts under Aqueous Conditions

The present invention relates to compositions and methods for achieving the efficient allylic oxidation of organic molecules, especially olefins and steroids, under aqueous conditions. The invention c..

Aminde Detection Method and Materials

Compounds linked to a solid support through a divalent linker moiety are disclosed. In particular, compounds such as 1-hydroxybenzotriazole-6-carboxylic acid are directly linked to the support under m..

SYNTHESIS METHODS OF HISTONE DEACETYLASE INHIBITORS (HDACIS)

Simple and efficient procedures for the synthesis of histone deacetylase inhibitors. The procedure may provide MS-275 in 72% overall yields.

PROCESSES FOR PLANT POLYSACCHARIDE CONVERSION

The present invention provides a novel process for ethanol fermentation.

METHOD AND DEVICE FOR ISOLATING A CHEMICALLY AND RADIOCHEMICALLY CLEANED 68GA-RADIO NUCLIDE AND FOR MARKING A MARKING PRECURSOR WITH THE 68GA-RADIO NUCLIDE

The invention relates to initial <68>Ge/Ga-generator elute which is guided directly to a cation exchanger, whereon <68 >Ga is quantitatively absorbed and is cleaned simultaneously in a chemical and ra..

ANTIOXIDANT AND PARAMAGNETIC HEPARIN-NITROXIDE DERIVATIVES

The present invention relates to novel heparin-nitroxide derivatives comprising heparin and at least two and more nitroxides/polynitroxide radicals that are covalently coupled to heparin by derivatisa..

METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF CANCER

The invention relates to an isolated regulatory nucleic acid, comprising a nucleic acid sequence according to SEQ ID NO 2 or a biologically active fragment thereof that can be specifically amplified a..

USE OF 3-(INDOLYL)- OR 3-(AZAINDOLYL)-4-ARYLMALEIMIDE DERIVATIVES IN LEUKENIA MANAGEMENT

The present invention relates to the use of a compound of formula (I) wherein R1 is H, C1-C6-alkyl, phenyl-C1-C4-alkyl or phenyl, R2 is a phenyl group which is substituted with 2 or 3 C1-C6-alkoxy gro..

3-(indolyl)- or 3-(azaindolyl)-4-arylmaleimide derivatives for use in the treatment of colon and gastric adenocarcinoma

The present invention relates to the use of a compound of formula (I) wherein R 1 , and R 3 are as defined in the description and R 2 is a phenyl group which is substituted with 2 or 3 C 1 -G 6 alkoxy..

UNIVERSAL PHOSPHORAMIDITE FOR PREPARATION OF MODIFIED BIOMOLECULES AND SURFACES

Reagents useful for attaching biomolecules (e.g., proteins, oligonucleotides, and other biomolecules) to a surface, processes of attaching molecules to a surface to form modified surfaces using these ..

CONJUGATED MONOMERS AND POLYMERS AND PREPARATION AND USE THEREOF

Disclosed are new conjugated compounds (e.g., monomers and polymers) that include ladder-type moieties which can be used for preparing semiconducting materials. Such conjugated compounds can exhibit h..

CHALCOGENIDE COMPOUNDS WITH A CLAY-LIKE CATION-EXCHANGE CAPACITY AND METHODS OF USE

Chalcogenide compounds with cation exchange capability and methods of using the compounds are described. Compounds of the general formula A2xMxSn3-XS6 are described wherein x is 0.1-0.95, A is Li+, Na..

ENHANCING THE PHYSICAL PROPERTIES OF SEMI-CRYSTALLINE POLYMERS VIA SOLID-STATE SHEAR PULVERIZATION

Solid-state shear pulverization of semi-crystalline polymers and copolymers thereof and related methods for enhanced crystallization kinetics and physical/mechanical properties.

Modified Acrylic Block Copolymers For Hydrogels and Pressure Sensitive Wet Adhesives

A method of producing an acrylic block copolymer comprising hydrophobic poly (lower alkyl methoacrylate), hydrophilic poly (lower alkyl methacrylic acid), and hydrophobic poly (lower alkyl methacrylat..

CATALYTIC ENANTIOSELECTIVE SYNTHESIS OF FLAVANONES AND CHROMANES

Various chromanone, flavanone and abyssinone compounds as can be prepares enantioselectively using a chiral thiourea catalyst.

NETWORKS FOR ORGANIC REACTIONS AND COMPOUNDS

A method for analyzing a collection of organic chemical reactions and compounds reported in the literature in the form of a complex network in either a normal, one-mode graph or a bipartite graph is d..

AMINOPYRIDINE DIMER COMPOUNDS, COMPOSITIONS AND RELATED METHODS FOR NEURONAL NITRIC OXIDE SYNTHASE INHIBITION

Nitric oxide synthase (NOS) inhibitor compounds comprising bi-terminal aromatic ring moieties, and related methods of NOS inhibition.

Method of Synthesizing Acetonide-Protected Catechol-Containing Compounds and Intermediates Produced Therein

The inventors disclose here a novel, facile approach to the synthesis of acetonide-protected catechol-containing compounds having at least one amine group. In specific embodiments, the invention provi..

SYSTEMS AND METHODS FOR SELECTIVE ALCOHOL PRODUCTION

The present invention relates to metabolic engineering issues related to flux determinism in core primary-metabolism pathways. In particular, the present invention relates to alcohol (e.g., butanol) p..

TETRATOPIC PHENYL COMPOUNDS, RELATED METAL-ORGANIC FRAMEWORK MATERIALS AND POST-ASSEMBLY ELABORATION

Disclosed are tetratopic carboxylic acid phenyl for use in metal-organic framework compounds. These compounds are useful in catalysis, gas storage, sensing, biological imaging, drug delivery and gas a..

CLICK CHEMISTRY, MOLECULAR TRANSPORT JUNCTIONS, AND COLORIMETRIC DETECTION OF COPPER

Click chemistry is used to construct molecular transport junctions (MTJs) through assembly of a molecular wire across a nanogap formed between two electrodes. Also disclosed are methods of using click..

ANTIFOULING HYDROGELS, COATINGS, AND METHODS OF SYNTHESIS AND USE THEREOF

The invention provides an antifouling hydrogel comprising an effective amount of antifouling polymer modified with a compound containing catechol functional groups to yield a modified antifouling poly..

CHIRAL PYRROLIDINE CORE COMPOUNDS EN ROUTE TO INHIBITORS OF NITRIC OXIDE SYNTHASE

Diastereomeric pyrrolidine compounds and methods of preparation, as can be used en route to the preparation of a range of nitric oxide synthase inhibitors.

Short Duplex Probes for Enhanced Target Hybridization

The present disclosure is directed to compositions and methods for detecting or associating with a target polynucleotide.

METHODS FOR TOTAL NITROGEN REMOVAL FROM WASTE STREAMS

A method and related apparatus for oxidation and reduction of a reduced aqueous nitrogen contaminant.

Zinc-activated contrast agents

The present invention relates to contrast agents for magnetic resonance imaging (MRI). In particular, the present invention relates to MRI contrast agents that are activated in the presence of zinc(II..

Apparatus and methods for water treatment

An apparatus and method for treatment of water borne oxidized contaminants, using hydrogen as an electron donor for denitrification and reduction of other oxidized contaminants. Preliminary results re..

SELF-ASSEMBLING POLY(DIOL CITRATES)-PROTEIN HYDROGELS

The present invention can be directed to poly(diol-citrate)-based copolymers, compositions thereof comprising protein components and methods of use and assembly.

Solid phase host compositions

A new family of silicon-based polymers has been prepared in which organic host components are bound covalently. The polymer is a polysilsesquioxane matrix comprising, for example, hosts such as cyclod..

Nanoarrays of single virus particles, methods and instrumentation for the fabrication and use thereof

A novel coordination chemistry or metal ion binding approach to controlling the site-isolation and orientation of virus particles, such as TMV, on a nanoarray template generated by lithography includi..

PROCESS FOR CONTINUOUS SOLVENT PRODUCTION

A continuous process for production of solvents, particularly acetone-butanol-ethanol (ABE) using fermentation of solventogenic microorganisms and gas stripping is provided. The solventogenic microorg..

Hydroamination of Alkenes

A method includes reacting an amino group, a composition including rhodium and an organic ligand, and a substrate having structural formula (I) in a reaction mixture. R1 is an organic group including ..

APPARATUS AND METHOD FOR APPLYING A FILM ON A SUBSTRATE

A system that incorporates teachings of the present disclosure may include, for example, an apparatus having a plurality of applicators, each applicator with an ingress opening to receive a liquid, an..

WATER REPELLENT METAL-ORGANIC FRAMEWORKS, PROCESS FOR MAKING AND USES REGARDING SAME

Microwave assisted synthesis may be used to produce water-repellent metallic organic frameworks (MOFs) molecules. The water-repellent MOFs contain non-polar functional groups, such as a trifluorometho..

SLOW RELEASE OF ORGANOBORONIC ACIDS IN CROSS-COUPLING REACTIONS

A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a protected organoboronic acid represented..

CATALYTIC COMPOSITIONS, COMPOSITION PRODUCTION METHODS, AND AQUEOUS SOLUTION TREATMENT METHODS

Composition production methods are provided that can include providing PdO nanoparticles on a nitrogen-doped titanium oxide surface to form a catalytic mixture. Catalytic compositions and/or bacterici..

METHOD FOR FORMING ALLYLIC ALCOHOLS

A method of performing a chemical reaction includes reacting an allyl donor and a substrate in a reaction mixture, and forming a homoallylic alcohol in the reaction mixture. The substrate may be an al..

HIGHLY PERMEABLE POLYMERIC MEMBRANES

Provided are substantially flat membranes that include a block or graft co-polymer and a water transport protein, such as Aquaporin-Z, or a synthetic mimic of such proteins. Also provided are methods ..

SOLVENT REMOVAL AND RECOVERY FROM INORGANIC AND ORGANIC SOLUTIONS

A process for recovering solvents from inorganic and organic solutions is disclosed. The process utilizes a polymer capable of selectively extracting the solvent from the inorganic or organic solution..

METHOD FOR THE SYNTHESIS OF A-RING AROMATIZED ACETYL MINOCYCLINES

The invention relates to a method for the production of A-ring aromatized acetyl minocyclines. The aim of the invention to provide a less complex method for the production of A-ring aromatized acetyl ..

METHOD FOR THE SYNTHESIS OF A-RING AROMATIZED ACETYL MINOCYCLINES

The invention relates to a process for production of A-ring aromatized acetyl-minocycline.The object of the invention, a resource-light process for the production of A-ring aromatized acetyl-Minocycli..

DIRECTED ASSEMBLY OF THREE-DIMENSIONAL STRUCTURES WITH MICRON-SCALE FEATURES

Polyelectrolyte inks comprising a solvent, a cationic polyelectrolyte dissolved in the solvent, and an anionic polyelectrolyte dissolved in the solvent, are described. The concentration of at least on..

Selective Aliphatic C-H Oxidation

A composition including a complex of a metal, a tetradentate ligand, at least one ancillary ligand, and a counterion may be used for selective sp3 C-H bond oxidation. The tetradentate ligand may inclu..

NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF

The invention relates to pyridinyl nicotinic acetylcholine receptor ligands, compositions comprising an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand and methods to treat or ..

Selective reduction of glycerol by porous silicon

The invention provides a method to prepare 1,3-propanediol from glycerol. The glycerol is contacted with porous silicon in the presence of an acid to provide the resulting 1,3-propanediol. The porous ..

WATER SOLUBILIZATION OF CELLULOSICS AND RELATED COMPOUNDS

The present invention is directed toward a method of solubilizing melaninic, ligninic, chitinic, and/or cellulosic material. The method includes providing melaninic, ligninic, chitinic, and/or cellulo..

MODIFIED POLYDICYCLOPENTADIENES

The present invention provides novel, modified polydicyclopentadienes and methods to prepare modified polydicyclopentadienes. The modified polydicyclopentadienes prepared by the methods of the inventi..

Methods for the Preparation of Thiazolidinethione Indene-Based Chiral Auxiliaries

Methods for the preparation of indene-based thiazolidinethiones are provided comprising contacting 1-amino-2,3-dihydro-1H-inden-2-ol, or a substituted derivative thereof, with an acid under suitable r..

APPARATUS AND METHOD FOR CARRYING OUT MULTIPLE REACTIONS

The invention provides methods and an apparatus useful for site-isolating reagents or catalysts during chemical reactions. The methods and apparatus are useful for carrying out cascade or domino react..

SPRAY DRIED MICROBES AND METHODS OF PREPARATION AND USE

The invention provides spray-dried preparations of microbes and methods of using those microbes.

y'-Ni3Al MATRIX PHASE Ni-BASED ALLOY AND COATING COMPOSITIONS MODIFIED BY REACTIVE ELEMENT CO-ADDITIONS AND Si

An alloy including about 16 at% to about 23 at% Al; about 3 at% to about 10 at% Cr; up to about 5 at% Si; up to about 0.3 at% of at least two reactive elements selected from Y, Hf, Zr, La, and Ce; and..

SYNTHESIS OF POLYCYCLIC PROCYANIDINS

The invention provides compounds that are A-type procyanidins. The compounds can be prepared by reacting flavylium salts with catechins or analogs thereof, for example, under anhydrous conditions in a..

SOLUBILIZATION OF COAL AND BIOCONVERSION OF COAL TO METHANE AND OTHER USEFUL PRODUCTS

Coal is contacted, or treated, with at least one aromatic alcohol and/or cycloaliphatic alcohol to solubilize at least a portion of the treated coal. The treated coal is optionally bioconverted to pro..

AUTOMATED SOLUTION-PHASE ITERATIVE SYNTHESIS

The first method for iterative solution-phase biomolecule synthesis is described. The method requires only 3 or fewer equivalents of building block at each coupling cycle, and incorporates a FSPE step..

Environmentally sensitive foldable oligomers

The invention relates to oligomers of cholic acid, cholate derivatives and amino acids called "foldamers" that undergo conformational changes in response to changes in temperature, solvent polarity, s..

BIFUNCTIONAL LACTIDE MONOMER DERIVATIVE AND POLYMERS AND MATERIALS PREPARED USING THE SAME

The invention described herein provides a novel lactide monomer derivative and process for preparing the lactide monomer derivative. The monomer derivative of the invention is bifunctional in nature, ..

POLYLACTIDE COMPOSITES AND METHODS OF PRODUCING THE SAME

Embodiments of polylactide composites comprise a polylactide, and a polymerized natural oil dispersed inside the polylactide.

PREPARATION OF SOLVENT-BORNE POLYMERIC BIOACTIVE COATINGS

Processes for preparation of a protein-polymer composite material are provided according to embodiments of the present invention which include providing an admixture of a polymer resin, a surfactant a..

NON-THERMAL PLASMA SYNTHESIS WITH CARBON COMPONENT

The disclosure herein describes a method for producing ammonia by introducing N2, CO and water into a non-thermal plasma in the presence of a catalyst, the catalyst being effective to promote the disa..

DETECTION OF NUCLEIC ACID SEQUENCE DIFFERENCES USING COUPLED LIGASE DETECTION AND POLYMERASE CHAIN REACTIONS

The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction m..

SOLVENT-BORNE POLYMERIC BIOACTIVE COATINGS FOR THE FACILITATED REMOVAL OF BIOORGANIC STAINS

Protein-polymer composite materials are provided according to embodiments of the present invention that include an admixture of a polymer resin, a surfactant and a non-aqueous organic solvent. An aque..

HOT-MELT ADHESIVE AND METHOD FOR THE MANUFACTURE THEREOF

The invention relates to a hot-melt adhesive, comprising at least one polysaccharide ester (6) obtained through the reaction of a polysaccharide (5) with an imidazolide (3) in molten imidazole (1). Th..

TETRAZINE-BASED BIO-ORTHOGONAL COUPLING REAGENTS AND METHODS

Coupling reactions, suitable for use in organic or aqueous media, are performed by contacting a 1,2,4,5-tetrazine with a dienophile. The dienophile may be covalently bonded to a protein, and the coupl..

METHOD OF MAKING STABLE, HOMOGENEOUS POTASSIUM HYDRIDE DISPERSIONS

A stable, homogeneous dispersion of potassium hydride is formed by reacting a mixture of wax and potassium metal with hydrogen.

REDUCED DYE PROBES FOR THE DETECTION OF RADICAL OXYGEN SPECIES

Reduced dyes, such as hydrocyanines, deuterocyanines, and/or other deuterated dyes, such as deuteraled leuco dyes, capable of detecting one or more reactive oxygen species are described herein The red..

PREPARATION OF SYNTHETIC NUCLEOSIDES VIA p-ALLYL TRANSITION METAL COMPLEX FORMATION

This invention provides highly regioselective and stereoselective processes for preparing synthetic nucleosides. A process for the preparation of synthetic nucleosides is provided that comprises a) pr..

POLYOXOMETALATE WATER OXIDATION CATALYSTS AND METHODS OF USE THEREOF

Homogeneous water oxidation catalysts (WOCs) for the oxidation of water to produce hydrogen ions and oxygen, and methods of making and using thereof are described herein. In a preferred embodiment, th..

METHODS OF PREPARING 1-DEOXY-SPHINGOID BASES AND DERIVATIVES THEREOF

Novel methods of synthesizing 1-deoxy-sphingoid bases and derivatives are disclosed. The synthesis is achieved from commercially available and inexpensive starting materials. The process includes thio..

COMPOUNDS, INTERMEDIATES, AND METHODS OF PREPARING THE SAME

The present disclosure provides optionally substituted seven-membered ring isomers of naturally occurring carbohydrate compounds, methods of synthesizing these compounds, intermediate compounds, metho..

PROCESSES FOR PREPARING 5,7 DIAMINOPYRAZOLO[1,5-a] PYRIMIDINE COMPOUNDS

Processes for the preparation of certain 5,7-diaminopyrazolo[1,5-a]pyrimidine compounds comprising the reaction of a primary or secondary amine and a protected 5-halo-7-aminopyrazolo[1,5-a]pyrimidine ..

Method of manufacture of 1,3-dioxolane and 1,3-oxathiolane nucleosides

Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiol..

TRIDENTATE PLATINUM (II) COMPLEXES

A platinum (II) complex of the general formula (I) or (II), in which Ar1, Ar2, and Ar3 are each independently aryl, heteroaryl, or heterocyclic. Ar1, Ar2, and Ar3 together form a tridentate ligand coo..

PLATINUM(II) DI(2-PYRAZOLYL)BENZENE CHLORIDE ANALOGS AND USES

Synthesis of platinum(II) di(2-pyrazolyl)benzene chloride and analogs includes forming a 1,3-di-substituted benzene including two aromatic five-membered heterocycles, and reacting the 1,3-di-substitut..

METHODS OF IDENTIFYING MOLECULAR FUNCTION

Disclosed herein are methods for identifying the molecular function of compounds, methods of iterative evolution of compounds, and a surface having high chemical diversity for performing the disclosed..

SCREENING METHOD TO IDENTIFY MOLECULES HAVING THE ABILITY TO MODULATE THE ACTIVITY OF A CATALYST

The present invention provides methods in which to screen or identify molecules that can have catalytic activity or that can alter a catalyst's activity.

COMPOUND ARRAYS FOR SAMPLE PROFILING

The invention provides arrays of compound for use in profiling samples. The arrays include compounds bind to components of the samples at relatively low affinities. The avidity of compounds binding to..

BACTERIUM FOR PRODUCTION OF FATTY ACIDS

A bacterium that produces fatty acids is disclosed. The bacteria further contains at least one modified polar cell layer.

FABRICATING POROUS MATERIALS USING THIXOTROPIC GELS

Methods, apparatuses, and systems for fabricating porous materials using thixotropic gels. A shear force is applied to a thixotropic material causing the material to flow. Multiple components are adde..

TRI-2-NAPHTHYLAMINES

The invention relates to tri-2-naphthylamines that can be useful in a variety of optical devices as hole-transport materials. For example, the tri-2-naphthylamines can be useful as hole-transport mate..

CYCLOPAMINE ANALOGS

The invention provides novel derivatives of cyclopamine having the following formula.

MOLECULAR RECTIFIERS COMPRISING DIAMONDOIDS

Provided is a molecular rectifier comprised of a diamondoid molecule and an electron acceptor attached to the diamondoid molecule. The electron acceptor is generally an electron accepting aromatic spe..

Preparing a colorless ionic liquid comprises reaction of heteroatom containing compound with quaternizing agent, where at least one heteroatom act as electron pair

Preparing a colorless ionic liquid (I) comprises: reaction of heteroatom containing compound, in which at least one heteroatom act as electron pair, with each of quaternizing agent under conditions th..

GLUR2 RECEPTOR MODULATORS

The present invention provides for compositions and methods for modulating the GluR2 receptor. It is based, at least in part, on the discovery, by X- ray crystallography, that a known GluR2 agonist bi..

SYNTHESIS OF OLIGOMERIC NEOLIGNANS AND THEIR USE

Compounds having the structure formule (I) and their uses are described herein.

ON-DEMAND MICROFLUIDIC DROPLET OR BUBBLE GENERATION

Microfluidic systems and methods can dispense single or multiple fluid particles (such as a gas or other fluid bubble) or an encapsulated particle (e.g., a bead or biological cell) into a microchannel..

PREPARATION OF FUNCTIONAL POLYMERS

The process of the present invention is directed toward conducting highly selective, high yield post polymerization reactions on polymers to prepare functionalized polymers. An embodiment of the prese..

LIVING SYNTHESIS OF CONDUCTING POLYMERS INCLUDING REGIOREGULAR POLYMERS, POLYTHIOPHENES, AND BLOCK COPOLYMERS

Regioregular poly(3-alkylthiophenes) and other polythiophenes can be prepared by living polymerization which have good solubility, processability and environmental stability. The polymerization method..

IMPROVED CONTROLLED RADICAL POLYMERIZATION PROCESSES

A transition metal mediated chain transfer agent controlled polymerization process is described. The process combines the advantages of atom transfer radical polymerization (ATRP) and reversible addit..

PURIFICATION METHODS AND PURIFIED CONJUGATED POLYMERS

Metal complexing agents are used to purify polymers including conducting polymers to provide very low metal content. The process comprises precipitating the polymer in solution into a solvent system c..

CHIRAL INDOLE INTERMEDIATES AND THEIR FLUORESCENT CYANINE DYES CONTAINING FUNCTIONAL GROUPS

This invention relates to the functionalized cyanine dyes and more particularly, to the synthesis of chiral 3-substituted 2,3'-dimethyl-3H-indole and its derivatives as intermediates for preparation o..

QUENCHED DENDRIMERIC DYES FOR BRIGHT DETECTION

The present invention presents designs for high extinction quenched "dyedrons" that can be activated by conversion of a single acceptor/quencher in the molecular assembly to a fluorescent state. The q..

POLYMERIZATION INHIBITOR COMPOSITION AND METHOD OF INHIBITING POLYMERIZATION OF DISTILLABLE MONOMERS

The present invention relates to a polymerization inhibitor composition and a method of inhibiting polymerization of distillable monomers in liquid and evaporated/condensed phases with the polymerizat..

PREPARATION OF FUNCTIONAL STAR MACROMOLECULES

A process for constructing multi-arm star macromolecules with uniform properties, high molecular weight and narrow molecular weight distribution using free radical polymerization is described.

MONOLITHIC POLYMER CROSSLINKED COMPOSITE MATERIALS AND METHODS OF MAKING

A bidentate free radical crosslinking initiator binds chemically to silica and silica rich surfaces and enables the free radical based polymerization of various materials such as styrene, divinylbenze..

PRE-FORMED ASSEMBLIES OF SOLGEL-DERIVED NANOPARTICLES AS 3-D SCAFFOLDS FOR COMPOSITES AND AEROGELS

A composite material that includes a dopant comprised of pre-formed, three dimensional assemblies of skeletal structures that are comprised of solgel derived nanoparticles. The composite material incl..

SOY-BASED POLYOLS

The invention provides B-sides of urethane formulations, wherein the B-sides comprise both alcohol and epoxy moieties. Also provided are urethane formulations comprising the B-side of the invention, a..

METHOD OF PRODUCING LOWER ALCOHOLS FROM GLYCEROL

This invention relates generally to a process for value-added processing of fats and oils to yield glycerol and glycerol derivatives. More particularly, the process converts glycerol to acetol and the..

Method Of Producing Lower Alcohols From Glycerol

A reactive-separation process converts glycerin into lower alcohols, having boiling points less than 200 DEG C., at high yields. Conversion of natural glycerin to propylene glycol through an acetol in..

FUNCTIONALIZATION OF ORGANIC SURFACES

The present invention relates to functionalizing a surface of an organic material. For example, surfaces of materials having C-H bonds, such as polymers having C-H bonds, can be functionalized. In cer..

SYNTHESIS OF ACENES AND HYDROXY-ACENES

A method comprising reducing an acenequinone to form an acenepolyhydrodiol by exposing the acenequinone to a reducing environment comprising an alkoxyaluminate.

In situ Plating And Soldering Of Materials Covered With A Surface Film

The disclosed subject matter provides systems and methods for etching and/or metal plating of substrate materials. An exemplary method in accordance with the disclosed subject matter for metal-plating..

PHOTOLABILE COMPOUNDS

The present invention describes Photolabile Compounds methods for use of the compounds. The Photolabile Compounds have a photoreleasable ligand, which can be biologically active, and which is photorel..

STRUCTURES HAVING AN ADJUSTED MECHANICAL PROPERTY

In various embodiments, the properties of a cross-linkable polymer can be changed by modifying the degree of cross-linking. The degree of cross-linking can be modified on a localized basis using litho..

SUBSTRATE LASER OXIDE REMOVAL PROCESS FOLLOWED BY ELECTRO OR IMMERSION PLATING

Method of ablating the surface of a substrate including providing a dry substrate and an electrolyte source, ablating the surface of the dry substrate to at least partially remove a native oxide layer..

Surface-modified structures, useful e.g. in optical or catalytic applications, comprise substrate, e.g. of glass, silicate primary coating and secondary coating, e.g. of metal

A novel surface-modified structure (I) comprises (a) a substrate, (b) a silicate primary coating and (c) a secondary coating and/or particles containing element(s) other than silica and oxygen. The ch..

Method For The Determination Of Intra- And Intermolecular Interactions In Aqueous Solution

The present invention relates to the determination of intra- or intermolecular interaction between molecules in aqueous solution, said method comprising the steps of: (a) determining the dehydration (..

METHOD FOR THE STEREOSELECTIVE SYNTHESIS OF PHOSPHORUS COMPOUNDS

The present invention relates to a method for the stereoselective synthesis of phosphorus compounds, wherein in the first reaction step a chiral auxiliary is covalently bound to the phosphorus atom of..

PROCESS AND APPARATUS FOR ION CHANNEL CHARACTERIZATION

The present invention provides a process and an apparatus for performing the process, for ion channel characterisation, especially for determination of the impact of effector compounds onto the ion ch..

MEANS FOR TREATING MYOSIN-RELATED DISEASES

This invention relates to a method of designing a modulator of a myosin, the method comprising molecular modeling of a compound such that the modeled compound interacts with at least three amino acid ..

METHODS FOR IDENTIFYING NUCLEOTIDE LIGANDS

Methods of identifying associations between nucleotide ligands and target molecules include amplifying a pool of non-random oligonucleotides to form libraries of oligonucleotides, contacting the libra..

Mesoporous Inorganic Oxide Spheres and Method of Making Same

A method of preparing mesoporous inorganic oxide spherical particles includes providing a reaction mixture capable of producing mesoporous inorganic oxide spheres; heating the reaction mixture to prod..

CURCUMIN DERIVATIVES AND THEIR USE AS RADIOPROTECTORS

Disclosed are compositions relating to analogues, derivatives, and metabolites of curcumin, methods of synthesis thereof, and methods for use of said compositions. This abstract is intended as a scann..

HYBRID HOST MATERIALS FOR ELECTROPHOSPHORESCENT DEVICES

Compounds (including polymers) for use in hybrid host materials which can be used in electroluminescent devices. The compounds comprise at least one electron- transporting moiety and at least one hole..

METHOD FOR THE SENSITIVE DETECTION OF POLYAMINO ACIDS AND OTHER MACRO-MOLECULES

The invention relates to a method for the detection of an analyte containing polyamino acid. The object of the invention is to detect polyamino acids in a highly sensitive manner. The object is achiev..

Device and Method for Preparing and Performing Multiple Polymerase Chain Reactions

The present invention relates to methods, kits and devices with multiple open reaction chambers having multiple pre-deposited primer compositions, and a basic sample loading mechanism that utilizes an..

TRIOXANE MONOMERS AND DIMERS

Monomeric and dimeric trioxane fluoroaryl amides, 5-carbon-linked, C-10 non-acetal trioxane dimer esters; trioxane silylamides; and trioxane dimer orthoesters and methods of their use for treating sub..

THERMALLY STABLE VOLATILE FILM PRECURSORS

A precursor for the deposition of a thin film by atomic layer deposition is provided. The compound has the formula MxLy where M is a metal and L is an amidrazone-derived ligand or an amidate-derived l..

NEW RAC1 INHIBITORS AS POTENTIAL PHARMACOLOGICAL AGENTS FOR HEART FAILURE TREATMENT

The present invention finds application in the field of medicine and, in particular, to new compounds particularly active in inhibiting Rac1 member of the Rho family. Pharmaceutical preparations conta..

A METHOD FOR THE FORMATION OF MEGAMITOCHONDRIA

The present invention relates to an in-vitro method for the formation of megamitochondria in cells, wherein the cells are grown in a suitable fermentation medium acidulated with lactic acid to pH valu..

FLUORINATED NANODIAMOND AS A PRECURSOR FOR SOLID SUBSTRATE SURFACE COATING USING WET CHEMISTRY

The present invention is directed to nanodiamond (ND) surface coatings and methods of making same. Such coatings are formed by a covalent linkage of ND crystals to a particular surface via linker spec..

LARGE SCALE MICROBIAL CULTURE METHOD

A new culture method for producing high levels of a metabolite, such as succinic acid uses oxygen rich culture without pH adjustment to increase the biomass, acclimation in under oxygen lean condition..

FULLERNENE COMPOSITIONS AND METHODS FOR PHOTOCHEMICAL PURIFICATION

In various embodiments, the present disclosure describes fullerene derivatives that are capable of photocatalytically generating reactive oxygen species in the presence of ultraviolet and/or visible l..

Fluorescent fused-ring traizoles that inhibit cell proliferation and uses thereof

Fused-ring triazole compounds which inhibit proliferation of cells and exhibit a unique and intense fluorescence are provided. Also provided are methods for synthesizing these compounds and methods fo..

LIGANDS SPECIFIC FOR CANNABINOID RECEPTOR SUBTYPE 2

A compound of Formula I: (I) has activity as a cannabinoid receptor antagonist. In Formula 1, R1 is unsubstituted or substituted aryl, unsubstituted or substituted cycloalkyl, unsubstituted or substit..

VINYL SUBSTITUTED FATTY ACIDS

Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty ac..

Fluorous reaction systems

The present invention provides a method for carrying out a chemical reaction comprising the steps of forming an organic/fluorous solubilizing liquid phase comprising a solvent system. The solvent syst..

METHODS FOR THE PREPARATION OF IRCINIASTATIN AND ANALOGS THEREOF

Methods for the preparation of irciniastatins, including (+)-irciniastatin A and (-)- irciniastatin B, as well as analogs thereof, are described.

CROSS-LINKED POLYMER NETWORK FORMED BY SEQUENTIAL CROSS-LINKING

The convention concerns methods for preparing a cross-linked polymer network comprising: - forming a plurality of cross-links in a polymer network by (i) addition polymerization or (ii) ionic polymeri..

METHOD FOR ASSESSMENT OF FOLATE PHENOTYPES, DISEASE RISK, AND RESPONSE TO THERAPY

The invention provides a method for measuring the levels of 5- methyltetrahydrofolate (5-MTHF), tetrahydrofolate (THF), and 5,10-MTHF in a biological sample. The method includes employing an isotope d..

ACETYLENE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES

The invention relates to radiolabeled compounds and their use in methods of imaging amyloid deposits, as well as to methods of their manufacture. The invention also relates to compounds for inhibiting..

POLYVINYL CHLORIDE CONTAINING MULTIARMED STAR COPOLYMERS

The invention concerns processes for the production of multiarmed star copolymers comprising polymerizing vinyl chloride with a multifunctional initiator in the presence of Na2S2O4 and water. The inve..

METHODS OF IDENTIFYING AND USING GENERAL OR ALTERNATIVE SPLICING INHIBITORS

The present invention is based on the discovery of a cell-based system to identify novel modulators of splicing or splicing dependent processes. The cell- based system of the present invention utilize..

CATALYSIS OF FLUORINE ADDITION TO DOUBLE BONDS

Catalyzed methods for adding fluorine, F2, across carbon-carbon double bonds are disclosed. Use of these methods for labeling by radioactive isotope 18F and methods for improving yields of novel isoto..

Fatty Acid Monomers To Reduce Emissions and Toughen Polymers

Novel fatty acid monomers and methods for their synthesis are provided for use in polymerization reactions. Fatty acid monomers are employed as reactive diluents in the polymerization of vinyl esters ..

Production And Uses Of Carbon Suboxides

Methods for the reduction of gaseous carbon dioxide emissions from combustion or oxidation reactions are provided. The various methods involve the formation of carbon suboxides and/or polymerized carb..

POLY(ETHYLENE GLYCOL) AND POLY(ETHYLENE OXIDE) BY INITIATED CHEMICAL VAPOR DEPOSITION

A method for ionic polymerization of ethylene oxide. In the first step of the method, a gaseous monomer composition comprising ethylene oxide at a first flow rate is mixed with a gaseous ionic polymer..

CROSSLINKED HYDROGELS

The present invention preferably provides for a method of forming and the resulting solid polymer gel composition comprising polyethylene imine and at least one hydrogen bonding polymer. The compositi..

Lead sensor and methods of use

A fluorophore that forms a complex with Pb ions is disclosed. The fluorophore/lead complex fluoresces with an intensity greater than complexes formed by the fluorophore with other metals. The fluoroph..

Basic Acetophenones as Inhibitors of No-Synthases

Use of the substance characterized by general structural formula (I) for the preparation of an agent inhibiting the enzymatic activity of NO-synthase, R1, R2, R3, R4 and/or R5 being hydrogen, an alkyl..

ANTIMICROBIAL PEPTIDES MADE OF HYDRA

A nucleic acid molecule, selected from the group consisting of a) a nucleic acid molecule having the nucleotide sequence shown in SEQ ID:NO 1, 4 or 6, b) a nucleic acid molecule coding a peptide with ..

INHIBITORS OF DIMETHYLARGININE DIMETHYLAMINOHYDROLASE

The invention relates to an inhibitor of dimethylarginine dimethylaminohydrolase (DDAH) of general structural formula (I), wherein B is a branched or unbranched, substituted or non-substituted, satura..

DERIVATE VON N

The invention relates to physically-chemically and pharmacokinetically enhanced N ?-hydroxy-L-arginine (NOHA) derivatives and a method for producing the NOHA derivatives having enhanced physical-chemi..

METHOD FOR IMPROVED BIOACTIVATION OF MEDICATIONS

The invention relates to a prodrug comprising a partial structure having the general formula (I) or (II), where R1 and R2 are hydrogen, alkyl, or aryl radicals.

RADIO-OPAQUE POLYMER BIOMATERIALS

Iodinated and/or brominated derivatives of aromatic dihydroxy monomers are prepared and polymerized to form radio-opaque polymers. The monomers may also be copolymerized with other dihydroxy monomers...

APPARATUSES AND METHODS FOR DETERMINING PROTEASE ACTIVITY

The present invention relates to compositions and an apparatuses for determining protease activity. The compositions of the invention contain a reporter protein fused to at least one protease cleavage..

EXPRESSION SYSTEM COMPOSITIONS AND METHODS

The present invention relates to novel expression systems and methods for preparing samples for 3D structure determination of a protein based on a protein expression vector, E. coli host, and specific..

SYSTEM FOR DEHUMIDIFYING, HEATING AND/COOLING OF A LIQUID

The invention relates to an absorber (1) or a regenerator. A liquid in said absorber (1) runs across an exchange surface to interact with a gas for the exchange of humidity. The liquid is supplied to ..

RESERVOIR

The invention relates to a reservoir (1) for storing two pressureless fluids (2; 3). An insert (12) can be inserted into a reservoir base (6) of the reservoir. Said insert has a storage container (20)..

DEVICE FOR DISINFECTING WATER BY MEANS OF ANODIC OXIDATION

The invention relates to a device for disinfecting water by means of anodic oxidation, wherein a reservoir (10) is provided for disinfected water, wherein a feed line (15) leads from the water to be d..

ACTUATION VIA SURFACE CHEMISTRY INDUCED SURFACE STRESS

A method of controlling macroscopic strain of a porous structure includes contacting a porous structure with a modifying agent which chemically adsorbs to a surface of the porous structure and modifie..

INORGANIC-ORGANIC COMPOSITE FLUORESCENT SUBSTANCE

The present invention relates to a composite fluorescent substance, comprising an inorganic matrix and an organic fluorescent dye, wherein the inorganic matrix is constructed of an inorganic compound ..

ORGANO-CASCADE CATALYSIS: ONE-POT PRODUCTION OF CHEMICAL LIBRARIES

A method for production of a chemical library is provided, where the method involves: reacting, in a single vessel, a) a plurality, x, of aldehydes and/or ketones; and b) either (i) a plurality, y, of..

SYNTHESIS OF BIO-FUNCTIONALIZED RARE EARTH DOPED UPCONVERTING NANOPHOSPHORS

Methods for preparing rare earth doped monodisperse, hexagonal phase upconverting nanophosphors, the steps of which include: dissolving one or more rare earth precursor compounds and one or more host ..

CONVERSION OF CARBON DIOXIDE TO ORGANIC PRODUCTS

The invention relates to various embodiments of an environmentally beneficial method for reducing carbon dioxide. The methods in accordance with the invention include electrochemically or photoelectro..

FUNCTIONALIZED GRAPHENE SHEETS HAVING HIGH CARBON TO OXYGEN RATIOS

Functionalized graphene sheets having a carbon to oxygen molar ratio of at least about 23:1 and method of preparing the same.

HIGH-YIELD ACTIVATION OF POLYMER SURFACES FOR COVALENT ATTACHMENT OF MOLECULES

Polymer surfaces coated with organometallic layers, wherein the organometallic layers and polymer surfaces have functional groups that react to bond the organometallic layer to the polymer surface wit..

Organic Vapor Jet Deposition Using an Exhaust

Methods and systems for organic vapor jet deposition are provided, where an exhaust is disposed between adjacent nozzles. One or more carrier gases may be provided and ejected from a plurality of nozz..

DEVICE AND METHOD FOR ORGANIC VAPOR JET DEPOSITION

A device and a method for facilitating the deposition and patterning of organic materials onto substrates utilizing the vapor transport mechanisms of organic vapor phase deposition is provided. The de..

INITIATOR-TIGHTENED COMPOSITIONS

Disclosed herein are gel and plastic compositions comprising tightened layers of polymerized vinyl monomers, as well as methods of making the same, where the layers are tightened in having smaller por..

BETULINIC ACID DERIVATIVES AND METHODS OF USE THEREOF

This invention features betulinic acid derivatives having the formula: wherein the variables are defined herein. The invention also provides related compounds and intermediates thereof, as well as pha..

HYBRID PROKARYOTIC-EUKARYOTIC TUBULINS AND USE THEREOF

The present invention embraces hybrid Prosthecobacter- eukaryotic tubulin proteins and use thereof for identifying agents that modulate the activity of tubulin.

FUNCTIONAL POLYSOBUTYLENE BASED MACROMONOMERS AND METHODS FOR MAKING AND USING THE SAME

A method of synthesizing a functionalized polymer represented by the structural formula (I) comprising a step of reacting a polymer represented by structural formula (II) with a compound Nu1 -M to nuc..

THIOPHENE-BASED CONJUGATED POLYMERS FOR DETECTION OF EXPLOSIVES

A device comprises a sensing element, wherein the sensing element includes a polymer or a copolymer having at least one unit of structural formula (I) having particular substituents for R' and R, form..

POLYISOBUTYLENE-BASED POLYURETHANES

An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a so..

MODIFIED POLYMERS AND METHODS FOR MAKING AND USING THE SAME

The present invention provides block copolymers, e.g., thermoplastic elastomers, having at least one monomer that is covalently bonded to a sulfonate moiety. The present invention also provides block ..

COPOLYMERS HAVING POLYISOBUTYLENE AND BIODEGRADABLE POLYMER SEGMENTS

The present invention pertains to copolymers having one or more polyisobutylene segments and one or more biodegradable polymer segments, to methods of making such copolymers, to medical articles that ..

END-CAPPED POLYMER CHAINS AND PRODUCTS THEREOF

Methods are described herein for converting carbocationically terminated polymers to anionically terminated polymers. These methods comprise: (a) providing a carbocationically terminated polymeric moi..

Polymerization of aromatic monomers using derivatives of hematin

Hematin, a hydroxyferriprotoporphyrin, is derivatized with one or more non-proteinaceous amphipathic groups. The derivatized hematin can serve as a mimic of horseradish peroxidase in polymerizing arom..

Functional Hydrocarbon Polymers and Process for Producing Same

A method of synthesizing a compound of formula (IIIe), comprising a step of reacting a compound of formula (IIIc): A functional polymer of formula (XXXa): The variables in formulas (IIIc), (IIIe), and..

Methods for forming copolymers comprising olefin and protected or unprotected hydroxystyrene units

Novel methods for forming copolymers, including block copolymers, which comprise one or more olefin units and one or more protected or unprotected hydroxystyrene units are provided.

HIGHLY Z-SELECTIVE OLEFIN METATHESIS

The present invention relates generally to catalysts and processes for the Z-selective formation of internal olefin(s) from terminal olefin(s) via homo-metathesis reactions.

CATALYSTS AND PROCESSES FOR THE FORMATION OF TERMINAL OLEFINS BY ETHENOLYSIS

The present invention relates generally to catalysts and processes for the formation of terminal olefin(s) from internal olefin(s) via ethenolysis reactions. The ethenolysis reactions may proceed with..

CATALYSTS FOR METATHESIS REACTONS INCLUDING ENANTIOSELECTIVE OLEFIN METATHESIS, AND RELATED METHODS

The present invention provides compositions comprising metal complexes, and related methods. In some embodiments, metal complexes of the invention may be useful as catalysts for chemical reactions, in..

METHODS AND APPARATUS FOR THE SYNTHESIS OF USEFUL COMPOUNDS

The present invention relates to methods and apparatus for activation of a low reactivity, non-polar chemical compound, hi one example embodiment, the method comprises introducing the low reactivity c..

Process Intensification In Microreactors

The present disclosure provides for a chemical reactor which includes elongate chambers defining an arrangement and including first, second, and third elongate chambers adapted to support respective d..

GLUCOSE SENSORS AND METHODS OF MANUFACTURE THEREOF

Disclosed herein is a device that functions as a glucose sensor. The device has a reference electrode; a counter electrode, a working electrode; an electrically conducting membrane; an enzyme layer; a..

CHEMICAL OXIDIZATION OF VOLATILE ORGANIC COMPOUND

PROBLEM TO BE SOLVED: To effectively oxidize volatile organic compounds in the soil. ; SOLUTION: Volatile organic compounds are removed from the contaminated soil by introducing one or both of a water..

FULLY CROSSLINKED CHEMICALLY STRUCTURED MONOLAYERS

The present invention relates to a structured monolayer, which is composed of low molecular weight aromatics and in the lateral direction of fully networked, with the mono-layer on one of the two surf..

ODOR SAMPLES OF PEROXIDIC EXPLOSIVES

The invention relates to the use of a neutral ionic liquid for stabilizing peroxidic explosives and for producing stable solutions of peroxidic explosives. The invention further relates to stable comp..

Enantioselective production of alpha-hydroxy carbonyl compounds

The invention relates to a process for the regioselective and enantioselective preparation of +--hydroxy carbonyl compounds from +--ketocarbonyl compounds via enzymatic reduction.

METHODS AND COMPOSITIONS FOR INHIBITING CLOSTRIDIUM DIFFICILE SPORE GERMINATION AND OUTGROWTH

Certain bile acids, including novel bile acids, and derivatives thereof can be used to inhibit the germination of C. difficile spores and/or the growth of C. difficile cells. The methods and compositi..

TREATING CATALYSTS

A method includes contacting a catalyst including a metal having an average particle size of approximately one nanometer or greater with SO2; and reducing the average particle size of the metal.

SULFUR-TOLERANT WATER-GAS SHIFT CATALYSTS

A method for oxidizing carbon monoxide by a water-gas shift (WGS) reaction and a method for reducing carbon dioxide by a reverse water-gas shift (RWGS) reaction, both using a catalyst of the formula x..

HETEROCYCLIC INHIBITORS OF NECROPTOSIS

The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-a) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas ..

Method for de novo detection of sequences in nucleic acids:target sequencing by fragmentation

The present invention provides a method for determining nucleic acid sequences of a template nucleic acid that requires no prior knowledge of the nucleic acid sequence present in the template nucleic ..

New substituted bisoxazoline ligands, useful as chiral catalyst in asymmetric organic synthesis, preferably nitroaldol reaction

Substituted bisoxazoline ligands (I) are new. Substituted bisoxazoline ligands of formula (I) are new.R1, R2, R3 = aryl, e.g. phenyl or alkyl, e.g. methyl, isopropyl or tert-butyl. Independent claims ..

Polyoxadiazole polymers

Polyoxadiazole polymer (I), (II) or (III) is new. Polyoxadiazole polymer of formula (I), (II) or (III) is new. n : >= 1, preferably 6-10; m, p, q : integer; X : [1,3,4]oxadiazole derivative of formula..

METHOD FOR THE SOLID PHASE-BASED PRODUCTION OF PHOSPHATE-BRIDGED NUCLEOSIDE CONJUGATES

The invention relates to a method for producing phosphate-bridged nucleoside conjugates. In the method, a cyclosaligenyl nucleotide is produced first, to which a linker is added, which is used to perf..

CROSSLINKED POLYCYCLOOCTENE

Chemically crosslinked polycyclooctene having excellent shape recovery properties is prepared by ring-opening metathesis polymerization of cis-cyclooctene followed by chemical crosslinking. The crossl..

POLYESTERS WITH GRAFTED ZWITTERIONS

The invention relates to polymers, such as aliphatic polyesters, with grafted zwitterions More particularly, the invention relates to polyester-graft-phosphorylcholine polymers prepared by ring-openin..

POLYMERIC COMPOSITIONS, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME

Disclosed herein is a polymeric composition comprising a polymeric composition comprising a first crosslinked network; and a second crosslinked network; wherein the first crosslinked network is crossl..

RAPID CELL BLOCK EMBEDDING METHOD AND APPARATUS

PROBLEM TO BE SOLVED: To provide a method and apparatus for rapidly embedding cells that utilizes a flow-through embedding technique. ; SOLUTION: The apparatus 10 includes a cell flow pathway 16 defin..

SINGLE PROBE, MULTIPLE TEMPERATURE, NUCLEIC ACID DETECTION METHODS, KITS, AND COMPOSITIONS

Provided herein are methods, kits, and compositions related to nucleic acid detection assays that allow discrimination of multiple target sequences with a single probe. In particular, provided herein ..

CROSS-LINKING OF SUPEROXIDE DISMUTASE MONOMERS

A stabilized superoxide dismutase (SOD1 ) analogue, wherein the side chains of two amino acids on two different SOD1 monomers are connected is provided. A method of producing a stabilized superoxide d..

CONJUGATE ADDITION REACTIONS USING BIFUNCTIONAL CINCHONA-ALKALOID-BASED CATALYSTS

One aspect of the present invention relates to quinine-based and quinidine-based catalysts. Another aspect of the present invention relates to a method of preparing a chiral, non-racemic compound from..

AMPHIPHILIC COMPOSITIONS AND METHODS FOR PREPARING AND USING SAME

The invention relates to amphiphilic C-glycoside derivatives, to methods of using them and to processes for synthesizing them. Specifically, the invention relates to novel cyclic and linear enone-glyc..

CHIRAL STATIONARY PHASES BASED ON XANTHONE DERIVATIVES

The present invention relates to the development of new chiral stationary phases (CSPs), named chiral xanthone stationary phases (CXSPs), and to the use thereof for the enantiomeric resolution by high..

DEVICE TO SEPARATE OLEFINS FROM PARAFFINS AND TO PURIFY OLEFINS AND USE THEREOF

The present invention discloses a device, which uses membranes, capable of separating olefins from paraffins. The device (1) considers an ultramicroporous ceramic membrane module, zeolite or silicate ..

ENZYMATIC SYNTHESIS OF ENANTIOMERICALLY ENRICHED DERIVATIVES OF CIS- AND TRANS-CYCLOPENTANE-1,2-DIAMINES

The invention relates to the enzymatic resolution of derivatives of cis- and trans-cyclopentane-1,2-diamines in order to obtain enantiomerically pure or enriched compounds, a method for preparing the ..

METHOD FOR THE DEHALOGENATION AND HYDROGENATION OF HALOGENATED AROMATIC MOLECULES

Method for the consecutive dehalogenation and hydrogenation of halogenated aromatic molecules under mild temperature and pressure conditions in the presence of a catalyst of rhodium complexes with bis..

TWO-ZONE FLUIDISED-BED REACTOR

The invention relates to a fluidised-bed reactor (10, 20, 30, 40) comprising two zones (11,12, 21, 22; 31, 32; 41, 42), in which the upper zone (11, 21, 31, 41) has a different cross-section to the lo..

METHOD FOR OBTAINING AROMATIC HYDROCARBONS FROM METHANE

The invention relates to a method for obtaining aromatic hydrocarbons from a stream containing at least one light hydrocarbon selected from the list comprising methane, ethane, ethylene, propane, prop..

SCALABLE PROCESS FOR PRODUCING PHYCOCYANINE

The invention relates to a three-stage process for producing and purifying phycocyanine originating from microalgae of the genus Anabaena, said process being characterised by scalability and high yiel..

HALOGENATED DERIVATIVES OF 2H-1,4-BENZOXAZIN-3(4H)-ONE WITH C-2 ALKYL CHAINS OR N-4 ACYL RESIDUES

The invention relates to halogenated derivatives of 2H-1,4-benzoxazin-3(4H)-one with C-2 alkyl chains or N-4 acyl residues. The invention belongs to the field of chemical compounds that can be used fo..

POLYMER MATRICES BASED ON POLYSACCHARIDES AND CYCLODEXTRINS

The present invention relates to novel materials based on polymer matrices obtained from polysaccharides, to the methods for obtaining same and to the uses thereof. More particularly, the invention re..

METHOD FOR THE PREPARATION OF MERO SESQUITERPENES FROM LABDANE DITERPENES

The present invention describes a method for producing mero sesquiterpenes, more specifically drimenylbenzenes and drimenylnaphthoquinones, by means of a Diels-Alder reaction between a labdane diterpe..

N-BENZYL IMIDAZOLE DERIVATIVES

The invention relates to the use of a N-benzyl 5-substituted imidazole derivative having the general formula (I) wherein R is (C1-3)alkyl, (C1-3)alkyloxy, halogen, nitro or cyano; R1 is formyl, (C1-6)..

METHOD FOR RELEASING AND LABELLING 0-GLYCANS

The application describes a one-pot process for releasing and labelling O-glycans from glycoproteins, thereby facilitating analysis via LC-ESI-MS-MS. The process comprises contacting the glycoprotein ..

COPOLYMERS

The invention provides a block copolypeptide comprising a hydrophilic heteropolypeptide block (A) and a hydrophobic homopolypeptide block (B). There is also provided a polymersome comprising a block c..

LANTHANIDE COMPOUNDS

A compound, according to general formula 1: M( II )Ln(III) 1-p-q Ce(III) p Tb(III) q M'(III) 3 O 7 wherein M(II) represents a divalent metal selected from the group of Ca, Sr and mixtures thereof; Ln(..

METHOD FOR PRODUCING CARBOXYLIC ACIDS BY OXIDATIVE CLEAVAGE OF UNSATURATED COMPOUNDS

The invention provides a method of oxidative cleavage of an unsaturated carbon-carbon bond, said method comprising contacting a reactant molecule containing a carbon-carbon unsaturated bond with a cat..

COORDINATION COMPLEX SYSTEM COMPRISING TAUTOMERIC LIGANDS

The invention relates to a coordination complex system comprising a ligand having the formula: R1-SO2-NH-P (XR2)2 (1a); or R1-SO2-N=PH (XR2)2 (1b); or R1-SO(OH)=N-P(XR2)2 (1c); wherein X is independen..

PROCESS FOR THE PRODUCTION OF PHOSPHOROUS COMPOUNDS

The invention is directed to a process for the production of certain phosphorous, namely urea, thio-urea and sulphonamide phosphorous compounds. The present invention provides a process for the produc..

METAL CATALYSTS COMPRISING NITROGEN-CONTAINING AROMATIC LIGANDS AND USE THEREOF

The present invention discloses a method for the preparation of a polymer from vinyl group-containing monomers comprising the step of polymerizing the vinyl group-containing monomers in the presence o..

THE METHOD OF GLYCERIC ACID SELECTIVE PREPARATION AND CATALYSTS FOR ITS REALIZATION

The present invention relates to chemical technology, particularly to the glyceric acid preparation method in process of selective glycerol oxidation in presence of new supported Pd catalyst. Object m..

PROCESS FOR THE OXIDATIVE CLEAVAGE OF THE ETHYLENIC DOUBLE BONDS OF VINYLAROMATICS

The invention relates to a process for the oxidative cleavage of vinylaromatics of the formula (1), with the characteristic feature that compounds of the formula (1) are oxidized in accordance with th..

METHOD FOR PRODUCING GLUCOSE DERIVATIVES

The present invention relates to a method for producing 2-0- (a- D-glucopyranosyl) -glycerate from a glucosyl donor and a glucosyl acceptor comprising the steps: - providing a sucrose phosphorylase (E..

NON-LEACHING HETEROGENEOUS CATALYST SYSTEMS FOR COUPLING REACTIONS

Supported palladium containing catalyst systems comprising an inorganic support material, a modifying agent covalently attached to said inorganic support material through at least one first functional..

Method for preparation of ruthenium-based metathesis catalysts with chelating alkylidene ligands

The invention relates to a method for preparation of ruthenium-based carbene catalysts with a chelating alkylidene ligand ("Hoveyda-type catalysts") by reacting a penta-coordinated ruthenium (II)-alky..

METHOD FOR THE PREPARATION OF REACTIVE [18] F FLUORIDE

The present invention is related to a method to obtain reactive [18F] fluorides in an organic medium suitable for radiolabelling without any azeotropic evaporation step, by the use of a solid phase ex..

INORGANIC-BINDING PEPTIDES AND QUALITY CONTROL METHODS USING THEM

The present invention relates to quality control methods using inorganic binding peptides, wherein inorganic entities are identified using inorganic-binding peptides specifically binding to the inorga..

MARKED PEPTIDES AND USE THEREOF FOR ASSAYING CIRCULATING IRAP

The invention relates to a method for assaying the circulating extracellular portion of the IRAP ("insulin-responsive aminopeptidase") protein, including at least one step of quantitatively assaying t..

Method for screening and selecting ligands

The present invention provides a method for screening of ligands wherein the target is a membrane protein, which is reconstituted into a membrane environment, using the surface plasmon resonance (SPR)..

EXTRACELLULAR ALLOSTERIC INHIBITOR BINDING DOMAIN FROM A TYROSINE KINASE RECEPTOR

The present invention relates to an extracellular binding domain for an allosteric inhibitor, whereby said binding domain is derived from a single membrane span tyrosine kinase receptor. More specific..

CYCLIC IMIDATE LIGANDS

The present invention relates to a use of a cyclic imidate as a ligand for catalysis in which the ligand contains substructure (Y) as a minimal structural motive, wherein the carbon atoms and the nitr..

COLORIMETRIC ASSAY FOR THE VISUAL DETECTION OF PRIMARY AND SECONDARY AMINES

The present invention concerns a novel method and kit system for the detection of solid-phase bound primary amines, secondary amines, or thiol groups comprising adding a fluid to said substrate and fu..

Improved cleaning of plasma chamber walls by adding of noble gas cleaning step

An improved reaction chamber and chamber cleaning process are disclosed able to remove water residues by making use of noble-gas plasma reactions. The chamber is easy to operate and the method is easi..

LOW TEMPERATURE DIRECT SELECTIVE METHANE TO METHANOL CONVERSION

Direct selective conversion of methane to methanol at low temperature (e.g. less than 300 degrees Celsius) is provided. The conversion is carried out at ambient pressure. An oxygen- activated catalyst..

METHOD FOR PRODUCING HYDROGEN BY WATER DISSOCIATION

The invention relates to a method for producing hydrogen from an aqueous medium containing an electron donor, a photosensitizer and a supported catalyst. The method is characterised in that the photos..

METHOD FOR HYBRIDIZING NUCLEIC ACIDS

The invention relates a method for manipulating, isolating, detecting or amplifying a target nucleic acid in a sample by hybridization with an oligonucleotide-oligocation molecule, comprising allowing..

CONTROLLED RELEASE OF ACTIVE ALDEHYDES AND KETONES FROM EQUILIBRATED DYNAMIC MIXTURES

The present invention concerns a dynamic mixture obtained by combining, in the presence of water, at least one diamine derivative, comprising at least one benzylamine moiety, with at least one active ..

CYCLITOLS AND THEIR DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS

The present invention is directed to polyphosphorylated and pyrophosphate derivatives of cyclitols. More particularly, the invention relates to polyphosphorylated and pyrophosphate derivatives of inos..

CATALYTIC PHOSPHINATION METHOD

The invention relates to a double or triple catalytic phosphination method, essentially performed in a single step of injecting phosphine groups on a di-, tri- or tetra-halobiaryl compound.

APPARATUS AND PROCESSES FOR GENERATING VARIABLE CONCENTRATION OF SOLUTES IN MICRODROPLETS

The present invention relates to systems and methods for generating microdroplets with varying concentrations of a particular solute from a solution at fixed concentration.

METHOD OF PREPARING AN ADDUCT

A method for identifying one or several molecular structure(s) having a high-affinity for a target of interest, said molecular structure(s) each comprising one nucleotide chain onto which is hybridize..

METHOD FOR THE SILANISATION OF POLYSACCHARIDES

The invention relates to a method for the silanisation of polysaccharides in a homogenous medium and in the presence of ionic liquids.

METHOD FOR SYNTHESIZING HYDROXY-BISPHOSPHONIC ACID DERIVATIVES

The present invention relates to a method for preparing a hydroxy-bisphosphonic acid derivative or a salt thereof, from the corresponding carboxylic acid, comprising the following steps: - activation ..

NOVEL COMPOUNDS, USE THEREOF AS MEDICAMENTS, AND METHOD FOR THE PREPARATION THEREOF

The invention relates to novel compounds having the following formula (I) in which: n is an integer from 1 to 12, in particular from 1 to 8, m and m' are, independently of one another, integers from 0..

THERMOREVERSIBLY CROSSLINKED ELASTIC BITUMINOUS COMPOSITION

The invention relates to a bituminous composition comprising at least one bitumen and at least one organogelling molecule taken alone or as a mixture, said organogelling molecule being represented by ..

AMPHIPHILIC BLOCK COPOLYMER AND METHOD FOR PREPARING SAME

The invention relates to an amphiphilic block copolymer, to the preparation thereof, and to the use thereof in the form of a self-stabilizing latex. The copolymer has the formula R5O-[-CH2CH2-O-]n-C(=..

METHOD FOR SYNTHESIZING POLYESTERS IN AN ACIDIC IONIC LIQUID MEDIUM

The present invention relates to a method for synthesizing polyesters or copolyesters having a mean molar mass, in mass MW, greater than 10000, by means of a direct polyesterification reaction between..

PROCESSES FOR THE PREPARATION OF THE ALPHA CRYSTAL POLYMORPH OF METAL PHTHALOCYANINES

Methods for producing a stabilised alpha copper phthalocyanine are described. More specifically such methods comprise forming a mixture of (a) a compound of the general formula (II), in which, R1 and ..

A PROCESS FOR PREPARING SILICA MICROPARTICLES

Silica core - shell microparticles are prepared by growing a porous silica shell from a silica precursor onto the surface of non- porous silica particle dispersed in a mixed surfactant solution under ..

Colorimetric anion sensor element

A sensor element suitable for colorimetric detection of anions in a sample, the sensor element comprising a water insoluble polymeric hydrogel having a polymer network defining a water permeable micro..

INTERMEDIATES IN THE ENANTIOSELECTIVE SYNTHESIS OF 3-(AMINOMETHYL)-5-METHYL-HEXANOIC ACID

(S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid or (S)-pregabalin is an anticonvulsive drug. In addition to its use as an anticonvulsive agent, pregabalin has also been indicated as a medicament in the..

CONJUGATED LINOLEIC ACID DERIVATIVES

A conjugated linoleic acid (CLA) derivative having the structure (I) wherein n is an integer from 1 to 10; and wherein the broken lines at positions 9 and 11, or at positions 10 and 12, are each doubl..

Alpha-GLYCOSYL THIOLS AND alpha-S-LINKED GLYCOLIPIDS

The present invention relates to stereoselective methods for the preparation of [alpha]-glycosyl thiols and [alpha]-S-linked glycosylceramides.

pH sensor device comprising an ionogel

A pH sensor comprising an ionic liquid stabilised in a gel so as to form an ionogel; and a pH indicator salt. The ionic liquid may comprise a trihexyltetradecylphosphonium [P6,6,6,14]+ cation and one ..

Making a stationary phase for separations from electrochemically polymerised monomer

A method of fabricating the stationary phase of an analysis tool for subsequent use in analytical separations (e.g. chromatography), includes the steps of electrochemically growing the stationary phas..

Organosilane coating compositions and use thereof

A sol-gel coating composition comprising a hydrolysed organosilane, an arganometallic precursor and a corrosion inhibitor, wherein the corrosion inhibitor is a chelator for the organometallic precurso..

BIODEGRADABLE SOLVENTS FOR THE CHEMICAL INDUSTRY

This invention relates to ionic liquid (ILs) solvents for chemical synthesis based on an alkyl - imidazolium cation core containing ionic liquids which have enhanced biodegradability and reduced toxic..

COMPOSITIONS AND METHODS FOR EXPRESSING IN-FRAME MULTIMERIC PROTEINS

The present invention concerns methods and compositions for making and using multimeric, single chain proteins of a defined structure. The invention also includes nucleic acid expression systems for m..

METHOD OF SURFACE TREATING MICROFLUIDIC DEVICES

The formation of a barrier layer within individual channels or cavities of a microfluidic device is described. The barrier layer is effected through a gas phase deposition process, desirably implement..

IONIC LIQUID SOLVENTS

A chiral ionic compound comprising an alkyl substituted imidazolium or pyridinium cationic core having an alkyl ester side chain (-alkyl-C(O)O-) directly linked to the core and an associated counter a..

SYSTEM AND METHOD FOR MODELLING A MOLECULE WITH A GRAPH

Modelling a molecule by means of a graph, said graph comprising vertices and edges, each edge having a specific type, and said graph having cyclic orderings on the half -edges about at least one of th..

ALLOSTERIC BINDING COMPOUNDS

The present invention relates to allosteric binding compounds of formula (I), especially for the treatment of CNS disorders, together with pharmaceutical compositions and methods of treatment includin..

IDENTIFICATION OF PHOSPHORYLATION SITES IN POLYPEPTIDES BY EMPLOYMENT OF URANYL PHOTOCLEAVAGE

The present invention relates to a method of cleaving a polypeptide at one or more phosphorylated residues. Said cleavage is induced by irradiation and is dependent on the presence of uranyl. The meth..

METHOD OF IDENTIFYING INDIVIDUALS AT RISK OF THIOPURINE DRUG RESISTANCE AND INTOLERANCE

The present invention is directed to a method of screening individuals for the presence or absence of one or more polymorphisms associated with the risk of thiopurine resistance or intolerance.

PREPOLYMER COMPOSITION

The present invention relates to a prepolymer composition comprising a polyester prepolymer, a vinyl-functional monomer having a vapour pressure which is less than styrene at 20 DEG C and an accelerat..

METHOD FOR THE DETERMINATION OF THE POSITION OF UNSATURATION IN A COMPOUND

A mass spectrometric method for determining the position of unsaturation in a compound is disclosed.

DYE COMPOSITION FOR USE IN PHOTOELECTRIC MATERIAL

A dye composition for use in a photoelectric material, the dye composition comprising a plurality of dyes comprising a chromophore and at least one binding group for binding with a semiconductor (pref..

Polymer electrolytes and devices containing them

The application arises from studies that have shown that electrochemical cells containing SPEs including: (i) a non-volatile organic ionic salt; and (ii) an inorganic electrolyte salt have an improved..

SYNTHESIS OF AGELADINE A AND ANALOGS THEREOF

The invention describes a one pot process for synthesizing a compound of structure (I), or a tautomer thereof. A compound of structure (II), or a tautomer thereof, and an aldehyde of structure RdCHO a..

CONTROLLED POLYMERISATION PROCESS

The present invention relates to a controlled metathesis-driven polymerisation process which is particularly useful for the synthesis of biological polymers such as peptides and polymers. The inventio..

PEPTIDE PURIFICATION BY MEANS OF METAL ION AFFINITY CHROMATOGRAPHY

PROBLEM TO BE SOLVED: To provide an oligopeptide (tag) for purifying an objective protein and a polymer substrate for metal ion affinity chromatography. ; SOLUTION: The polymer substrate is functional..

Contoxin Analogues and Methods for Synthesizing Same

According to the present invention, there is provided a range of new conotoxin derivatives and methods for synthesizing these analogues and other intramolecular dicarba bridge-containing peptides, inc..

COMPOSITIONS AND USES THEREFOR

The invention is directed inter alia to the use of receptor-associated protein (RAP) polypeptide or a functional analog thereof to reduce amyloid oligomerisation and deposition and to reduce Ass assoc..

MOLECULARLY IMPRINTED POLYMERS, METHODS FOR THEIR PRODUCTION AND USES THEREOF

The present invention relates to methods of preparing molecularly imprinted polymers (MIPs) which facilitate chemical hydrolysis and more particularly the hydrolysis of chemical substrates which posse..

A METHOD FOR THE N-DEMETHYLATION OF N-METHYL HETEROCYCLES

The present invention provides methods of N-demethylating, N-methylated heterocycles and N-methyl, N-oxide heterocycles using a transition metal with an oxidation state of zero, ferrocene or substitut..

ANTIMALARIAL AGENTS THAT ARE INHIBITORS OF DIHYDROOROTATE DEHYDROGENASE

Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidi..

NOVEL BISMUTH(III) NSAID COMPOUNDS AND METHODS FOR THEIR USE

The present invention relates to the field of non-specific anti inflammatory drugs (NSAIDs). In particular, the invention relates to bismuth(III) tris-carboxylate complexes having the formula [Bi(III)..

AFFINITY LIGANDS AND METHODS FOR PROTEIN PURIFICATION

The present invention relates generally to affinity ligands and chemical affinity ligand-matrix conjugates for use as chromatographic adsorbents and methods which utilise the adsorbents in the purific..

TEMPERATURE-RESPONSIVE POLYMER PARTICLES IN PROTEIN SEPARATION APPLICATIONS

The present invention relates to a method for isolating proteins from a solution containing the proteins. The invention also relates to a method for the chromatographic separation of proteins. The pre..

Peptide purification by means of hard metal ion affinity chromatography

A polymer substrate functionalized with a functionality comprising at least one cyclic, metal ion coordinating ligand group which comprises at least 3 nitrogen donor atoms in the ring of the cyclic gr..

TERPENE SYNTHASES FROM SANTALUM

An isolated nucleic acid molecule that encodes a terpene synthase and is selected from among: a) a nucleic acid molecule comprising the sequence of nucleotides set forth in SEQ ID NO: 1, SEQ ID NO: 3 ..

METHOD OF OXIDISING ORGANIC COMPOUNDS

Disclosed herein is a method of oxidising an organic compound, wherein the oxidation is catalysed by nanoparticles of RuO2.Also disclosed are methods for forming the RuO2 nanoparticles.

ORGANOMETALLIC CATALYST AND PREPARATION THEREOF

The present invention relates to a method for producing an organometallic catalyst and an organometallic catalyst when produced by the method. The method comprises the steps of combining a polycarboxy..

PEPTIDE AND PHOSPHOPEPTIDE SYNTHESIS VIA PHOSPHATE ASSISTED LIGATION

Methods of preparing polypeptides and proteins. In particular, the invention has been developed as a method of preparing peptides and phosphopeptides through formation of a peptide bond via phosphate ..

Surface polymerisation process and polymer product using RAFT agent

A method of polymerising monomer to form polymer at the surface of particulate material, said method comprising: providing a dispersion of said particulate material in a continuous liquid phase, said ..

Tropoelastin Derivatives

The invention relates to derivatives of tropoelastin and variants of those derivatives. The invention further provides expression products and hybrid molecules of the derivatives and variants of the i..

FLOTATION AIDS AND PROCESSES FOR USING THE SAME

This invention relates to particulate and/or liquid droplet separation processes from liquids containing the same and the use of specific chemical additives to control surface wetting, hydrophobicity ..

NOVEL COMPOUNDS, DERIVATIVES THEREOF AND THEIR USE IN HETEROJUNCTION DEVICES

The invention relates to novel polyaromatic and polyheteroaromatic compounds and derivatives thereof. The compounds display high solubility in organic solvents. A further aspect of the invention relat..

NITROGEN-CONTAINING MACROCYCLIC CONJUGATES AS RADIOPHARMACEUTICALS

The present invention relates to compounds that are useful as metal ligands and which either contain a molecular recognition moiety or can be bound to a molecular recognition moiety and methods of mak..

PROCESS FOR THE PREPARATION OF ASYMMETRICAL BIS(THIOSEMICARBAZONES)

The present invention relates to a method of making asymmetrical bis(thiosemicarbazones), compounds useful as synthetic intermediates in the method, new bis(thiosemicarbazones) that can be readily acc..

PROCESS FOR GENERATION OF PROTEIN AND USES THEREOF

A method of generating a protein with an improved functional property, th e method comprising: (a) identifying at least one Target amino acid Residue in a first protein, wherein said Target amino acid..

IMMOBILIZED ENZYMES AND CO-FACTORS

The present invention is concerned with the immobilization of enzymes and their co-factors in a system which permits regeneration of the co-factors. Also included in the present invention are methods ..

METHOD FOR MAKING ORGANIC CARBONATES AND SULPHUR ANALOGUES

A method of making an organic carbonate compound or sulphur analogue thereof is provided, the method comprising reacting urea (or a urea derivative or analogue) with an organic compound comprising at ..

DINUCLEAR, QUADRUPLY-STRANDED COMPOUNDS COMPRISING PALLADIUM OR PLATINUM

The invention relates to a compound of formula (M2L4 where: M = a palladium or platinum metal ion; L = X = -O-, -S-, -NH-, or (-CH2-)n, where n = 1, 2 or 3; R2, R4, R5, R6 are each independently selec..

MODIFIED PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 MOLECULE AND METHODS BASED THEREON

The present invention relates to a modified plasminogen activator inhibitor type- 1 (PAI-1) molecule that displays an increased in vivo half-life of the active form of PAI- 1, but is deficient in one ..

METHOD FOR SYNTHESIZING XANTHOHUMOL

A method is provided for synthesizing xanthohumol by inserting a prenyl-group onto the aryl-ring via a para-Claisen rearrangement after using a Mitsunobu reaction to establish the key prenylether prec..

BORON SELECTIVE IONIC LIQUIDS AND POLYMERIC IONIC LIQUIDS, METHODS OF MAKING AND METHODS OF USE THEREOF

Boron selective ionic liquids and polymeric ionic liquids, methods of making and methods of using the same are disclosed.

MUSCARINIC RECEPTOR AGONIST

PROBLEM TO BE SOLVED: To provide a muscarinic receptor agonist stimulating cholinergic activity. ; SOLUTION: There is provided a compound of formula (I), wherein R<SB>3</SB>is H, CH<SB>2</SB>CH<SB>3</..

INTERFACE POLYMER

A method of depositing an anion exchange polymer on an electrode substrate, said method comprising: a) contacting an electrode substrate with an anion exchange polymer in ionic form, wherein the polym..

CAPACITIVE DEIONIZATION

A process for separating organic compounds from an aqueous medium, said process comprising: adding surfactant to the aqueous medium, such that the organic compounds interact with the surfactant to for..

A METHOD OF MAKING A HARD LATEX AND A HARD LATEX

A method of making a hard latex from a latex comprising an aqueous dispersion of a polymer, the method comprising the step of exposing the latex to infrared radiation.

PHOTOCATALYTIC FLUIDIZED BED REACTOR WITH HIGH ILLUMINATION EFFICIENCY FOR PHOTOCATALYTIC OXIDATION PROCESSES

The invention relates to the realization of synthesis of organic com not pounds or abatement of volatile organic compounds (VOCs) in gas-solid fluid- ised bed photocatalytic reactor with improved illu..

FULLY CROSSLINKED CHEMICALLY STRUCTURED MONOLAYERS

The present invention relates to a structured monolayer which is made up of low molecular weight aromatics and is fully crosslinked in the lateral direction, where the monolayer has a pattern of funct..

NOVEL SULFONIUM BORATE COMPLEX

A novel sulfonium borate complex, which can reduce the amount of fluorine ions produced during thermal cationic polymerization, and realize low-temperature, rapid curing properties in a thermal cation..

BICYCLIC MONOPHOSPHINES

A compound of formula (I): wherein: RP1 and RP2 are independently selected from C3-12 alkyl groups; RC is a C5-6 aryl group, optionally substituted by one or more groups selected from: C1-7 alkyl, C1-..

ALUMINUM COMPLEXES AND THEIR USE IN THE SYNTHESIS OF CYCLIC CARBONATES

Dimeric aluminium catalysts of formula I: and their use in catalysing the synthesis of cyclic carbonates from epoxides and carbon dioxide.

FORMATION OF 18F AND 19F FLUOROARENES BEARING REACTIVE FUNCTIONALITIES

An iodonium compound of formula (I): where RAR1 is a C5-6 aryl group, bearing at least one substituent selected from formyl, thionoacyl, acylamidocarboxy, thionoester, azo, C2-20 alkenyl, C2-20 alkyny..

METHOD FOR MONITORING THE DEHYBRIDI ZATION OF DOUBLE STRANDED NUCLEIC ACID

The present invention relates, in one aspect, to a method for monitoring the dehybridisation of double stranded nucleic acid, comprising the steps of: (a) providing a nucleic acid probe and a target n..

AMMOXIMATION PROCESS

A redox ammoximation process in which a ketone or aldehyde is reacted with ammonia and oxygen in the presence of a catalyst, wherein: the catalyst is an aluminophosphate based redox catalyst having th..

Methods of identifying modulators of CFTR/CK2 interaction

A method of identifying a compound capable of modulating CFTR/CK2 interaction and/or CFTR phosphorylation by CK2 comprising exposing CFTR and/or CK2 to a test compound and assessing the effect of the ..

POLYPEPTIDES, POLYNUCLEOTIDES AND USES THEREOF

A recombinant polynucleotide encoding migrating stimulating factor (MSF) or variants or fragments or derivatives or fusions thereof or fusions of said variants or fragments or derivatives. Reagents ar..

FLUORESCENCE LIFETIME AND FLUORESCENCE ASSAYS

The invention provides a method for determining a degree of phosphorylation of a substrate, for example a peptide substrate, using a fluorescence probe that acts alone or with another material and has..

N-MYRISTOYL TRANSFERASE INHIBITORS

The present invention relates to N-heterocyclic sulphonamide compounds, in particular pyrazole sulphonamide compounds, and their use as N-myristoyl transferase inhibitors.

WIDE TEMPERATURE-RANGE SMECTIC LIQUID CRYSTAL MATERIALS

A method of making a wide temperature-range smectic liquid crystal material comprises taking a wide temperature-range nematic mixture and doping this with a mesogenic silicon-containing material. Aspe..

PREPARATION OF HALOGEN AND HYDROGEN CONTAINING ALKENES OVER METAL FLUORIDE CATALYSTS

Halogenated alkenes, especially fluorinated alkenes can be prepared from halogenated and fluorinated alkanes, respectively, by dehydrohalogenation or dehydrofluorination in the presence of a high-surf..

METHOD FOR PRODUCING A MATERIAL CONTAINING ZINC OXIDE AND A SEMICONDUCTOR ELEMENT WITH A MATERIAL CONTAINING ZINC OXIDE

The invention relates, amongst other things to a method with the features given in the generic part of claim 1. According to the invention, a p-doped zinc oxide-containing material (30, 60, 125, 225, ..

CATALYST AND PROCESS

The invention is a method of dehydrogenating a hydrocarbon, especially an alkane, to form an unsaturated compound, especially an alkene, by contacting the alkane with a catalyst comprising a form of c..

MODULATION OF MIRNA ACTIVITY

Provided is a method of identifying a compound which modulates miRNA activity comprising (i) determining the ability of a test compound to alter the polyuridylation activity of a ZCCHC polypeptide whe..

PROBES COMPRISING FLUORESCENT ARTIFICIAL NUCLEOBASES AND USE THEREOF FOR DETECTION OF SINGLE BASE ALTERATION

The present invention relates to forced intercalation probes (FIT-probes) comprising at least one nucleoside analogue which comprises at least a fluorescent artificial nucleobase directly bound to a c..

A COMPOSITE COMPRISING AT LEAST ONE TYPE OF PERFLUOROALKYL-PERFLUORO-PHTHALOCYANINE

The present invention relates to a composite comprising at least one type of perfluoroalkyl-perfluoro-phthalocyanine, and to a method of producing such composite. The present invention also relates to..

FLUORESCENT DYES AND COMPLEXES

A fluorescent dye comprising a xanthene-derived fluorophore having the formula (I) wherein R1, R2, R3, R4, R5 and R6 are independently selected from H, alkyl, alkoxy, alcohol, ether, alkenyl, alkenoxy..

Dimethylthiofoxins and azafoxins which may be useful as ligands for G-protein coupled receptors

The invention provides compounds of general formulae (II) or (III), or pharmaceutically acceptable salts thereof. X is -CO-(Y)k-(Z)nor -SO2-(Y)k-(Z)nwherein k is 0 or 1, each Y is a cycloalkyl, polycy..

Conductive Polymer Compositions in Opto-Electrical Devices

A conductive polymer composition comprising: a polymer having a HOMO level greater than or equal to -5.7 eV and a dopant having a LUMO level less than -4.3 eV.

Ultrahydrophobic Surfaces and Methods for Their Production

The present invention relates to a method of producing an ultrahydrophobic surface, the method comprising providing a mixture comprising low surface energy material and a sacrificial material, forming..

POLYPEPTIDES INCLUDING MODIFIED CONSTANT REGIONS

Disclosed are processes for producing a variant polypeptide (e.g. antibodies) having increased binding affinity for an Fc[gamma]R, which processes comprise modifying the polypeptides by substitution o..

Compounds and their use in detecting an amino acid and/or latent fingerprint

The present invention relates to compounds of amino acids and/or latent fingerprints of formula:[Het]-CHOwherein Het is a nitrogen containing heterocyclic system in which a nitrogen atomis substituted..

Method for extending the life of chemical sensors

The method is described for extending the life of chemical sensors for determining individual components in the gas phase, the contact between fluoride-ion conductor and metal electrode being heated o..

Capillary arrangement used in electro-spraying ionization processes in mass spectrometry, e.g. for converting molecules having a high molecular mass (e.g. DNA) from a solution into ions has an electri

Capillary arrangement (10) has an electrically conducting metal oxide layer (4) for contacting a sample fluid in the arrangement. An Independent claim is also included for a process for the production..

Procedures and cutlery for the digestion of cells and the preservation and extraction of nucleic acids from living cells or tissues

The invention relates to a method for sample fixation, sample preservation, for cell disruption and extraction of nucleic acids in living cells, cell aggregates and tissue samples, and a working set f..

Method for Detecting Target Nucleic Acids Using Template Catalyzed Transfer Reactions

The present invention relates to the detection and quantification of nucleic acid sequences and to the sequence determination of nucleic acids using template catalyzed transfer reactions. The inventio..

Preparing mineral organic fertilizer from process water of hydrothermal carbonization of plant material comprises separating carbon and organic residual components from process water and isolating min

Preparing mineral organic fertilizer from process water of the hydrothermal carbonization of plant material, comprises separating carbon and organic residual components from the process water and isol..

POLYMER MICELLE COMPLEX INCLUDING NUCLEIC ACID

It is an object of the present invention to provide: a polyion complex that sufficiently retains a photosensitizing substance in serum and is excellent in terms of structural stability; a nucleic acid..

ENVIRONMENT-RESPONDING siRNA CARRIER USING DISULFIDE-CROSS-LINKED POLYMERIC MICELLE

Disclosed is a siRNA-encapsulating polymeric micelle complex (a polyion complex) having high monodispersibility and structural stability and excellent in the ability of transporting siRNA into a cell...

ORGANIC-INORGANIC HYBRID NANO PARTICLE COMPOSED OF NUCLEIC ACID CONJUGATE HAVING POLYETHYLENE GLYCOL BOUND THERETO AND CALCIUM PHOSPHATE

Disclosed is an organic-inorganic hybrid nano particle comprising a conjugate of a nucleic acid and a polyethylene glycol chain bound covalently to the nucleic acid and a calcium ion (Ca2+) and a phos..

CATIONIC POLY(AMINO ACIDS) AND USES THEREOF

Provided is an efficient delivery system for nucleic acids. Provided specifically are cationic poly(amino acids) that have a side chain having different amine functional groups in a portion that inclu..

POLYION COMPLEX OF DOUBLE-STRANDED RIBONUCLEIC ACID

PROBLEM TO BE SOLVED: To provide a delivery system useful for delivering a double-stranded ribonucleic acid that achieves gene silencing in glomeruli, particularly mesangial cells or other cells to th..

CONTRAST MEDIUM-CONTAINING ORGANIC-INORGANIC HYBRID PARTICLE

PROBLEM TO BE SOLVED: To provide a carrier for stably delivering an MRI contrast medium to a target site. ; SOLUTION: The organic-inorganic hybrid particle comprises a block copolymer containing an un..

COPOLYMER INCLUDING UNCHARGED HYDROPHILIC BLOCK AND CATIONIC POLYAMINO ACID BLOCK HAVING HYDROPHOBIC GROUP IN PART OF SIDE CHAINS, AND USE THEREOF

The present invention relates to a block copolymer containing an uncharged hydrophilic polymer chain block and a cationic polyamino acid chain block, wherein the hydrophilic polymer chain block is cov..

CHARGE CONVERSIONAL TERNARY POLYPLEX

Disclosed is a polymer composite (polyplex) that contains nucleic acid, a cationic polymer, and an anionic polymer. The anionic polymer covers the surface of the composite comprising the cationic poly..

ESTERASES FOR MONITORING PROTEIN BIOSYNTHESIS IN VITRO

The present invention relates to the use of an esterase for monitoring and/or tracking the synthesis of a protein, polypeptide or peptide in a cell-free translation system or in an in vivo expression ..

Expression vector for Bacillus species

The present invention is related to the use of the gsiB promoter as an inducible promoter in an expression system, whereby the promoter can be induced by a measure selected from the group comprising d..

IMIDAZO[1,5-B]PYRIDAZINAMIDO LIGANDS AND THEIR COMPLEXES

The invention relates to novel NN(R) ligands of the formula 1 (imidazo[1,5-b]pyridazine-substituted amino ligands) in uncharged or anionic form and catalysts which can be produced therewith, in partic..

TRIORGANO(AMINO)BORATES: ACTIVATION OF ALKALI METAL AMIDES, CONVERTING ALKALI METAL AMIDES INTO HYDROCARBON-SOLUBLE REAGENTS

The invention relates to triorgamo(amino)borates and to the production and use thereof. Object of the invention is it to make a chemical compound available those the synthesis of new chemical produ..

SURFACE-TREATED COPPER FOIL AND COPPER-CLAD LAMINATE

To provide a surface treated copper foil satisfying all of the bonding strength to polyimide film, chemical resistance, and etching property, and to provide a CCL using the surface treated copper foil..

Superior Liquid Uptake Resins for Polymer-supported Synthesis (SLURPS)

Background Solid phase synthesis, or polymer-supported synthesis, is a technique for chemical transformations in which molecules are bound to a solid, such as a polymer bead, during the reaction and..

Processing and Application of Cereal Processing Byproduct-Based Adhesives

Tech ID: 11321 / UC Case 2004-311-0 Abstract Processing and Application of Cereal Processing Byproduct-based Adhesives Full Description A novel processing and application method for cereal pro..

Scratch Resistant Polymer Blends

This invention relates to polypropylene-based polymer blends exhibiting enhanced scratch resistance. Polypropylene-based materials such as TPO’s are used in a broad range of applications, including..

Cost-Efficient, Biodegradable Microspheres with Control of Diameter, Density, Color and Surface Chemistry

BACKGROUND: Currently commercialized microspheres for flow measurement and bioscience applications are manufactured via polymerization processes that are costly or impossible to customize and require ..

Solid Base Transesterification Catalysts for Biodiesel Production

BACKGROUND: Biodiesel presents physical-chemical properties similar to petro-diesel, and can be used directly in the motor with no further significant mechanical modifications or expenditure in mainte..

Use of Magnetic Nanoparticles to remove Dispersed Nanoparticles from Aqueous Solutions

BACKGROUND: Carbon nanotubes (CNTs) are important structural blocks for the preparation of composites with unique optical, electrical, and mechanical properties and their production is expected to inc..

Novel Enantiomeric Chiral Alcohols

DESCRIPTION: University of California, Merced (UC Merced) researchers have synthesized novel enantiomeric chiral alcohols, derivatives of a phenyl isobutanol. These compounds feature a conformationall..

Improved Physical Methods for Increasing Stereoselectivity

BACKGROUND: Since 1988, the Food & Drug Administration has required that the enantiomeric composition of all drugs be known, making stereoselective reactions essential for the pharmaceuticals industry..

Sequential Sampling within a Portable Computing Environment

BACKGROUND: In industrial, agricultural, and warehouse/retail settings, there are many situations where sequential sampling and hypothesis testing could markedly improve productivity and quality contr..

Heterogeneous Copper Catalysts

BACKGROUND: The development of effective asymmetric reactions that enable the enantioselective formation of one chiral center over another continues to be an important area of research. A second impor..

Organic Multi-Photon Absorbing Molecules

BACKGROUND: Two-photon or other multi-photon absorbing molecules have been designed in a variety of technologies involving such subjects as optical data storage, 3-D microfabrication techniques, freq..

A Novel Class of Pre-Emergent Herbicides

The University of California is seeking industrial partners to commercialize a novel class of herbicidal compounds, the DHC’s. The DHC’s were developed by a major producer of ag chemicals. This co..

Nanoparticle Assembled Hollow Spheres

BACKGROUND: Nanoparticles with very small diameters (<100 nm) can be produced from a variety of compositions, such as metals, metal oxides, metal non-oxides, and polymers. The physical, chemical, and ..

Bifunctional Catalysts and Methods for Synthesis of Impermeable and Semipermeable Coatings

BACKGROUND: Fields that involve the handling of sensitive materials, such as electronics, chemicals, and biological agents need a means of safely isolating these items to protect them or the outside ..

Searching Composition Space in Combinatorial Chemistry by Monte Carlo Methods

BACKGROUND: Combinatorial chemistry involves searching a large compositional space for compounds with a high figure of merit in order to find a molecule with a given property. However, current methods..

Modular Adhesives and Energy-Dissipating Materials

BACKGROUND: Natural materials are renowned for their strength and toughness. Spider dragline silk has a breakage energy per unit weight two orders of magnitude greater than high tensile steel, and is ..

A Chemical Enhancer of Net Photosynthesis

A University of California researcher has isolated genes (described in PCT application #WO00029607A1) from the soil bacterium Sinorhizobium meliloti (a symbiont naturally found with alfalfa) that prod..

A Methyl Bromide Substitute for Agricultural Use

Methyl bromide is extremely important to United States and World agriculture (64,000,000 lbs. used in the U.S. in 1990), and is the most widely used and efficacious general-purpose fumigant in the wo..

One-Pot Organocopper Chemistry and Stereospecific Nucleoside Formation

A researcher at the University of California has made several inventions related to organic syntheses involving higher-order cuprates. Higher-order organocuprates are reagents containing copper atoms ..

Safe and Powerful Reductant

Researchers at the University of California have synthesized a family of compounds which have very strong reduction properties and are also inexpensive and exceptionally safe. Since 1947 the stand..

Synthesis of Beta-Amino Alcohols

Enantiomerically pure .-amino alcohols play an increasingly important role in both the treatment of a wide variety of human disorders and as chiral auxiliaries in organic synthesis. The importance of..

Poly(2-Methoxy,g-(2'Ethyl-Hexyloxy)-P-Phenylene Vinylene), MEH-PPV, and Methods for Use

BACKGROUND: The possibility of combining the important electronic and optical properties of semiconductors and metals with the attractive mechanical properties and processing advantages of polymers ha..

A Monoclonal Antibody Assay for Detecting Cyclodiene Insecticides

Researchers at the University of California (UC) have produced a mouse hybridoma cell line, which secretes monoclonal antibodies directed against the most common and persistent polychlorinated cyclod..

Novel Chromogenic Ionophores

Ionophores selectively complex with specific ions in sample solutions, and are widely used for measuring ion concentrations in such solutions in conjunction with ion-selective electrodes. University ..

Novel Self-Doped Polymers

PATENT ABSTRACT: A self-doped conducting polymer having along its backbone a .pi.- electron conjugated system which comprises a plurality of monomer units, between about 0.01 and 100 mole % of the uni..

Novel Conductive Polymers

POLYISOTHIANAPHTENE, A NEW CONDUCTING POLYMER UC Case No. 1984-044-2 U.S. Patent 4,640,748 Patent Abstract: A polymer having an isothianaphthene structure represented by the formula (Ia) and/..

Prevention of Browning in Fruits and Vegetables

Bruising or other mechanical wounding of fruits and vegetables cause many post-harvest problems; including the browning of injured and adjacent tissue. Currently, the only way to control browning indu..

Tough, Self-Healing Silicone Materials

Siloxane- and organosiloxane-based materials (collectively termed "silicones") are ubiquitous in commercially available goods and high technology applications, often in the form of oils, rubbers, resi..

Amide Forming Chemical Ligation under Mild Reagent-Free Conditions

BACKGROUND: Despite the importance of amide (peptide) bonds, there are currently few methods for their preparation. The synthesis of amide bonds is generally limited to methods requiring the use of e..

COMPOSITIONS AND METHODS FOR IN VITRO MOLECULAR SORTING COMPARTMENTALIZATION IN DOUBLE (W/O/W) EMULSIONS

The present invention provides an in vitro system for compartmentalization of molecular or cellular libraries and provides methods for selection and isolation of desired molecules or cells from the li..

Raman Spectroscopy Apparatus and Method for Continuous Chemical Analysis of Fluid Streams

The present invention provides apparatus and methods for analyzing the chemical composition of fluid streams using Raman spectroscopy. The apparatus includes a laser source for producing light having ..

Use of Drosophila Embryos for Delivery and High-throughput Screening of Chemical Compounds

Present-day drug discovery frequently involves screening hundreds of thousands of compounds for biological activity against a target molecule. Compound screening is typically preformed using cell-base..

Quantitative Analysis of Unresolved Isomers and Isobars by Tandem Mass Spectrometry

This novel and improved deconvolution method allows high-throughput, quantitative analysis of isobars from unresolved chromatographic peaks, and accurate quantification of isomers or isobars in a comp..

Electrochemical Reduction of Ferric Ions Using Hydrogen Gas

Solvent extraction/electrowinning (SXEW) is a growing segment of the copper industry, producing some of the best quality copper in the market. Electrowinning of copper is a highly energy-intensive pro..

Chemical Vapor Synthesis of Uniform Mixtures of Fine Powders

Producing homogeneous mixtures of fine powders using conventional methods can be a challenging task, especially when the mixture is a composite powder. This technology describes a process of synthesiz..

A Virtual Electrochemical Laboratory

This software-based invention simulates a laboratory environment that enables students to understand how common electrochemical experiments are performed. Easily installed on a Microsoft Windows plat..

Wastewater Treatment Igloos or "Poo-Gloos" for the Removal of Ammonia

Wastewater treatment lagoons are one of the most widespread treatment technologies in the United States and are suited for small to medium sized rural communities, animal feedlot operations, as well a..

Magnetic Activated Carbon Particles for Gold Recovery, Water Treatment and other Applications

This invention describes the process of mixing a magnetic material homogeneously with an activated carbon material. Activated carbon is commonly used to remove a number of materials from liquids and ..

Direct Reading, Quantitative Biosensors for Measuring Chemical Concentrations

Bioluminescence and chemiluminescence are chemical oxidation processes that result in photon emission. Adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide (NADH) are two molecules that ..

Novel Synthesis of Indoles

Technology This technology offers two main opportunities. First, it can produce a number of new 2-substituted Indoles that cannot be realized by the Fisher synthesis, and which can be used the ..

Chelating Polymer Directly Prepared from Ligand Initiator

Researchers at the University of British Columbia have developed a novel technique to initiate polymerization with metal-specific chelators of choice allowing for easier generation of metal coordinate..

Mesoporous Dendrimersilicas

Background Mesoporous Organisilicates have applications in diverse areas such as catalysis and environmental remediation. Use of heterogeneous catalysts (or heterogenized homogeneous catalysts) has..

Methods of Synthesizing Arborescent Polymers

Methods have been developed for the synthesis of branched (arborescent) homopolymers with a well-defined structure. These molecules, characterized by a cascade-branched (arborescent) architecture, bel..

Polymerizable Beta-Diketones for MIPs of Divalent or Trivalent D and F Block Metals

A process for preparing vinyl substituted beta-diketones includes reacting a halogen-containing beta-diketone with an olefin in a reaction zone under Heck coupling reaction conditions in the presence ..

Soluble, Processible Molecularly Imprinted Macromolecules

The scientific community's excitement for the use of molecularly imprinted polymers (MIPS) for sensors and filters is rising at an almost exponential rate, with the practical realization that plastics..

Vessel for Solid Phase Micro-Extraction (SPME) Chemical Sampling

Researchers at the Johns Hopkins University, Applied Physics Laboratory (JHU/APL) have further developed the Solid Phase Micro-Extraction (SPME) process. This a process whereby chemicals of interest a..

Fluid Sampling Interface for a Submerged Water-Borne Vehicle

It is unsafe and often impossible for humans to directly assess potentially hazardous environments. Today, unmanned vehicles and robots are often used to perform activities that are difficult, dangero..

Dual-Sided Microchannel Plate Detector Mount for Coaxial Time-of-Flight Mass Spectrometers

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland Security and the medical community lead the list. Current instruments ..

Polymer Based Lanthanide Luminescent Sensors for the Detection of Organophosphorous Compounds

A number of organophosphorus compounds are used in nerve agents, including the chemically similar organo-fluorophosphorus compounds found in nerve gasses such as Sarin and Soman. Detection and quantif..

Automated Propellant Blending (MSC-22757)

Abstract: Innovators at NASA Johnson Space Center have developed a safer, more consistent and economical way in which to blend propellants. Used mainly for the production of Zirconium Potassium Perch..

Ammonia Monitor Including Solid Phase pH Conditioning and a Liquid-Liquid Exchange Module (MSC-22270)

Abstract: The Ammonia Monitor Including Solid Phase pH Conditioning and a Liquid-Liquid Exchange Module is a new kind of analytical instrument that measures ammonia dissolved in water. It provides co..

UV-Curable Polyimides ()

Abstract: The National Aeronautics and Space Administration seeks to transfer technology for the development and production of polyimides using ultraviolet light, rather than heat, to effect polymeri..

Lightweight Ceramic Insulation and Method (MSC-20782)

Abstract: NASA has introduced an alternative approach to the fabrication of ceramic insulation that is capable of withstanding temperatures up to 1600 degrees C. The process takes water-soluble salts..

Low-Temperature Oxidation Catalysts (TOP1-466)

Abstract: NASA Langley Research Center is actively seeking partnerships and collaborations to commercialize its Low-Temperature Oxidation Catalysts technology. Several licensees are developing commer..

Low-Temperature Oxidation Catalysts (TOP1-466)

Abstract: NASA Langley Research Center has developed a family of catalysts for low-temperature oxidation of carbon monoxide and other gases. These oxidation catalysts have high activity at low temper..

Thermostable Purified Endoglucanases from Thermophilic Bacterium Acidothermus Cellulyticius

U.S. Patent 5,275,944 Technology Description A purified low molecular weight cellulase endoglucanase I having a molecular weight of between about 57,420 to about 74,580 daltons from Acidothermus ..

Process for Selection of Oxygen-tolerant Algal Mutants that Produce H.sub.2

U.S. Patent 5,871,952 Technology Description A process for selection of oxygen-tolerant, H.sub.2 -producing algal mutant cells comprising:(a) growing algal cells photoautotrophically under fluore..

Hydrogen Producting Using Hydrogenase-Containing Oxygenic Photosynthetic Organisms

U.S. Patent 6,989,252 Technology Description This invention relates to photosynthetic hydrogen production and specifically to a biophotolysis process, which can be cycled, for the temporal separa..

Fluorescence technique for on-line monitoring of state of hydrogen-producing microorganisms

U.S. Patent 7,229,785 Technology Description In situ fluorescence method to monitor state of sulfur-deprived algal culture's ability to produce H.sub.2 under sulfur depletion, comprising: a) prov..

Solar-Induced Chemical Vapor Deposition of Diamond-Type Carbon Films

U.S. Patent 5,346,729 Technology Description An improved chemical vapor deposition method for depositing transparent continuous coatings of sp.sup.3 -bonded diamond-type carbon films, comprising:..

Process for Selection of Oxygen-tolerant Algal Mutants that Produce H.sub.2

U.S. Patent 5,871,952 Technology Description A process for selection of oxygen-tolerant, H.sub.2 -producing algal mutant cells comprising:(a) growing algal cells photoautotrophically under fluore..

Plasma Enhanced Chemical Vapor Depositions (PECVD) Method of Forming Vanadium Oxide Films and Vanadium Oxide Thin-Films Prepared Thereby

U.S. Patent 6,156,395 Technology Description A method is disclosed of forming a vanadium oxide film on a substrate utilizing plasma enhanced chemical vapor deposition. The method includes positio..

Photoenhanced Anaerobic Digestion of Organic Acids

U.S. Patent 4,919,813 Technology Description A process is described for rapid conversion of organic acids and alcohols anaerobic digesters into hydrogen and carbon dioxide, the optimal precursor ..

Using liquid desiccant as a regenerable filter for capturing and deactivating contaminants

Technology Description A method, and systems for implementing such method, for purifying and conditioning air of weaponized contaminants. The method includes wetting a filter packing media with a salt..

Solid Lithium-Ion Electrolyte

Technology Description The present invention relates to the composition of a solid lithium-ion electrolyte based on the Li.sub.2 O--CeO.sub.2 --SiO.sub.2 system having good transparent characteristics..

Method and System for Simulating Heat and Mass Transfer in CoolingTowers

Technology Description The present invention is a system and method for simulating the performance of a cooling tower. More precisely, the simulator of the present invention predicts values related to..

CELLULOSE BASED HEART VALVE PROSTHESIS

An inventor at The University of Iowa has found that cellulose-based pliable and porous prosthesis structures can be molded into a solid matrix and formed to various geometries such as thin films, mem..

NEW, IMPROVED SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT) SYSTEM, TO PRODUCE TRANSAXIAL IMAGES IN A PLURALITY OF TRANSAXIAL PLANES THROUGH A BODY

A single photon emission computed tomography (SPECT) system for producing transaxial images in a plurality of transaxial planes through a body. The SPECT system includes a detector system with an in-p..

TERNARY SULFIDE ALLOYS THAT SHOW THERMAL BISTABILITY FOR A RANGE OF TEMPERATURES AND PROPERTIES USEFUL FOR SWITCHING ELEMENTS IN MICROELECTRONICS, THERMOSTATS, THERMAL RELAYS, OPTICAL RECORDING AND ME

The researchers invented new alloy compositions of ternary sulfides which exhibit a phase transition with hysteresis as a function of temperature for certain ranges of chemical compositions. The phase..

METHODS AND COMPOSITIONS FOR DEGRADATION OF NITROAROMATIC AND NITRAMINE POLLUTANTS

The invention describes a novel strain of bacteria, and methods and kits for using it to degrade a variety of Nitroaromatic, Nitramine and other pollutants. These pollutants are frequently generated i..

MATERIAL PROPERTY IDENTIFICATION SYSTEM AND METHODS

This technology relates to the identification of properties of nonlinear elastic materials, and to a system and methods of delineating distributive elastic properties, including thin-walled membrane s..

CATALYST DISPERSED IN SUPPORTED MOLTEN SALT

This new method uses microcrystallites of various materials as catalysts. The materials include metals, metal alloys and mixtures, and intermetallic compounds all of which are used as heterogeneous ca..

COST EFFECTIVE SUGAR-BASED BIODEGRADABLE POLYMERS (#91-26 & #88-30)

A new simplified method has been discovered for the preparation of a variety of new polymers using sugars such as sucrose and raffinose as starting materials. The method employs highly selective enzym..

METHOD FOR SYNTHESIZING C-GLYCOSIDES OF ULOSONIC ACIDS

A method for synthesizing C-glycosides of ulosonic acids such as Neu5Ac, by which diastereocontrolled synthesis of alpha-C-glycosides of ulosonic acids is attained. In the method of the present invent..

CHEMICAL SENSING ARRAY AND SENSOR STRUCTURE

A new chemical sensor made from an array of one or more fluorescent polymers selected to detect one or more analytes in a solution. The fluorescent polymers comprise of phenolic repeating units and on..

NAPHTHALENE DIOXYGENASE COMPOUNDS AND METHODS FOR THEIR USE

This new enzyme of naphthalene dioxygenase (NDO) provides an NDO or NDO related complex where at least one alpha-subunit polypeptide comprises a substituted amino acid. The invention also provides DNA..

PRODUCTION OF GLYOXYLIC ACID

The University of Iowa Research Foundation owns domestic and international patent rights to proprietary processes for the production of glyoxylic acid from glycolic acid and oxygen in the presence of ..

ARTIFICIAL ENDONUCLEASE

The invention provides an artificial (synthetic) endonuclease that exploits the exquisite specificity achieved by DNA binding proteins to deliver a metal to, i.e., in close proximity to, a gene or oth..

GAS STORAGE MATERIALS AND DEVICES

The invention describes a novel synthetic processes and intermediates for the production of porous metal-organic frameworks (MOFs) for the storage of gases, such as hydrogen. The storage of hydrogen, ..

CARBOXYLIC ACID REDUCTASE POLYPEPTIDE, NUCLEOTIDE SEQUENCE ENCODING SAME AND METHODS OF USE

The invention provides the nucleotide sequence and amino acid sequence for the enzyme carboxylic acid reductase isolated from bacteria. Expression cassettes, vectors, transformed cells, and variants a..

METHOD FOR SYNTHESIZING GLYCOAMINOGLYCANS

The invention is related to sulfo protected nitrogen-containing monosacchardies, methods of making the same, and to methods of making polysaccharides using sulfo protected monosaccharides or other pol..

METHOD FOR PREPARING LADDERANES

The invention describes a method for preparing a ladderane comprising, associating two polyene molecules with a template such that the polyene molecules are properly aligned to allow for formation of ..

DATA STORAGE MATERIALS

The invention describes materials and devices for use as an information storage system or for use as a material having a characteristic fluorescent energy. The materials and design of the invention in..

Solar Hydrogen Generation

Background The establishment of the hydrogen economy will require a non-fossil fuel source of hydrogen. One of the most promising alternatives is to use solar energy to generate hydrogen. Currently, t..

Microporous Mixed Matrix Membranes

Background Dense mixed matrix membranes have been researched for many years since they are easier to produce than zeolite membranes, they are durable and flexible, and they offer a performance enhance..

Lanthanide-Containing Conducting Polymers as Emissive Materials

Background This technology represents a novel method of assembling emissive materials with potential applications that include: hybrid, organic, and polymer light-emitting diodes (LEDs), flexible scre..

Inexpensive, efficient method for manufacturing organic photovoltaics and LEDs

Background The incorporation of active components such as semiconductor nanoparticles into conducting polymer matrices has many potential applications, including electronic materials, photovoltaic cel..

Electrochromic Material Based on a Conducting Ladder Polymer

Background Electrochromism is the phenomenon displayed when some type of matter reversibly changes color when a burst of charge is applied. Recent applications of electrochromic materials include elec..

Detection of Single Nanoparticle Collisions by Electrocatalytic Amplification and its Analytical Applications in Nanotechnology and Biotechnology

Background Current detector/sensor technology has been used to detect the presence of molecules in substances quickly and with relatively high sensitivity. For example, the average diabetic is able to..

Carbon Dioxide Capture by Aqueous Piperazine

Background The conventional process for CO2 absorption/stripping uses aqueous amines such as monoethanolamine (MEA). Piperazine has previously been identified as a very reactive amine. It is an attrac..

A New Method For Anion Metathesis

Background Organic salts are essential reactants in a number of important applications, including the preparation of reaction media, catalysts, precatalysts, analytical materials, solvent, and sensory..

Phenolate Constrained Geometry Polymerization Catalyst and Methods for Preparing ( 96053)

Scientists at Northwestern University have created a unique constrained geometry catalyst (CGC) for olefin polymerization by a simple cost effective one step-synthesis. Upon activation with strong Lew..

Silyl-Terminated Polymer and Method for Preparing Silyl-Terminated Polyolefins ( 96055)

A new class of a-olefin polymerization catalysts has been developed at Northwestern University. The catalysts in the presence of silanes efficiently produce silyl-capped polyolefins with controlled mo..

Perfluoronapthyl Substituted Boron Containing Catalyst Activator ( 96101

A novel Ziegler-Natta polymerization activator has been created at Northwestern University. Tris (b-perfluoronapthyl) borane (PNB) cocatalyzes Group 4 metal complexes into a powerful a-olefin polymeri..

NOx Reduction Catalyst ( 97039)

The invention relates to a method for the reduction of nitrogen oxides in gaseous streams such as the exhaust emission from a lean burn internal combustion. U.S. Patent No. 6,143,681

Supported Organometallic Catalysts for Hydrogenation and Olefin Polymerization ( 98038)

Northwestern University scientists have prepared a new class of olefin / arene hydrogenation and olefin polymerization heterogeneous catalysts that exhibit high conversion rates under ambient conditio..

Organosilicon Compounds and Uses Thereof ( 99043/99008)

Researchers at Northwestern University developed a series of novel silicone-based linkages as tools for the solid-phase synthesis of compounds containing a benzene ring. U.S. Patent No. 6,416,861..

Chemical CO2 Fixation: Cr(III) and Co(III) Salen Complexes as Highly Efficient Catalysts for the Coupling of CO2 and Epoxides (21048)

New highly active Cr(III)- and Co(III) catalyst systems for the coupling of CO2 and terminal epoxides to cyclic carbonates under extremely mild conditions. Carbon dioxide is an attractive and economic..

Method for the Preparation of Monodisperse High Molecular Weight Polymers (21062)

A novel method has been developed whereby monodisperse high molecular weight polymers (> 500,000 g/mol) can be prepared from a variety of synthetic, normally disperse high molecular weight polymers. ..

Solid Phase Organic Silicate Host Compositions (21075)

A new class of solid organic host – silicon (polysilsesquioxane) matrix polymers have been created. Inorganic silicates, which provide mesoporous cavities, and organic shape / size template molecul..

Method of Producing An Exfoliated Polymer-Clay Nanocomposite Through Solid-State Shear Pulverization (22089)

Well dispersed polymer-clay nanocomposites are readily produced with continuous solid state shear pulverization (S3P). Process affords polymer hybrid nanocomposites with enhanced properties in the abs..

Catalytic Synthesis of High Energy Density Nanocomposite Dielectric Materials (26136)

A process affording homogeneously dispersed ceramic nanoparticles within the matrix of processable, high-strength polymers. The high energy density polymer-metal oxide composites provide effective hig..

Enhanced Polymer Properties by Solid State Shear Pulverization (28003

Northwestern’s solid state shear pulverization (S3P) process improves the physical properties of a variety of homopolymers. Enhanced polymer crystallinity, mechanical and oxygen barrier properties a..

Neutral Bimetallic Transition Metal Napthldioxydiiminato Catalysts and Related Polymerization Methods (28037)

New bimetallic Ni olefin polymerization catalyst system. ADVANTAGE: Bimetallic olefin polymerization catalysts with increased activity, degree of and selectivity for methyl group branching, and c..

Polymer-Cellulose Composites via Solid-State Shear Pulverization (28135

Process for producing polymer-cellulose composites with enhanced properties. ADVANTAGES: A scalable process to produce well dispersed polymer-cellulose composites having enhanced properties, witho..

Surface-Immobilized Antimicrobial Peptoids (28138)

Northwestern researchers have developed peptoid mimics of antimicrobial peptides that can be immobilized onto surfaces, rendering these surfaces capable of compromising the membranes of attached bacte..

Selective Inhibitors of Nitric Oxide Synthases (21036/98009)

This discovery presents two series of compounds that demonstrate very high selectivity for inhibition of neuronal nitric oxide synthase (nNOS) over the inducible nitric oxide synthase (iNOS) enzymes, ..

Facile Direct Conjugation of Peptides, Peptide Modified Polymers and Therapeutic Agents to Tissue Surfaces. (27127)

Synthetic peptide-polymer conjugates are enzymatically coupled to cartilage under mild conditions through the formation of isopeptide bonds between the peptides and extra cellular matrix (ECM) protein..

Oligo(p-phenylene vinylene) amphiphiles and methods for self-assembly

INVENTION: Amphiphilic oligo(p-phenylene vinylene) compounds and methods of use en route to self-assembled composites and device fabrication. Accordingly, it is an object of the present invention ..

Novel Ion Exchange Materials for Heavy Metals Removal

INVENTION: The novel ion exchange materials are metal sulfide based materials. They are made of inexpensive, non-toxic elements. They can be prepared by solid state or hydrothermal synthesis and are c..

Polymer-Cellulose Composites via Solid-State Shear Pulverization

INVENTION: Process for producing polymer-cellulose composites with enhanced properties. ADVANTAGES: A scalable process to produce well dispersed polymer-cellulose composites having enhanced proper..

Chlorine-Resistant Reverse-Osmosis Membrane

Current state-of-the-art technology for reverse osmosis filtration of water has one major flaw: the addition of chlorine can cause the membrane to degrade. However, when treating saltwater or brackish..

Centrifuge Permeameter for Unsaturated Soils System

Current testing methods cannot measure the unsaturated hydraulic properties of granular materials simultaneously, and require long testing periods. They are impractical and involve the use of several ..

Centrifuge Permeameter for Unsaturated Soils System

Background Current testing methods cannot measure the unsaturated hydraulic properties of granular materials simultaneously, and require long testing periods. They are impractical and involve the use ..

Centrifuge Permeameter for Unsaturated Soils System

Binder Compositions for Laser Sintering Processes

Background Rapid prototyping has developed steadily as an industry over the past two decades. The leading four companies in the field had aggregate sales estimated at $387 million in 2007, approximate..

Advanced Polymer Membranes for the Purification of Hydrogen and Other Gases

Background Current methods for carbon dioxide removal and hydrogen purification are not only very expensive but also cause large losses of gas and use toxic chemicals. The hydrogen required in the ref..

Additive technology to eliminate bio-fouling in membranes; e.g., desalinization

Background One of the major roadblocks to widespread use of membranes for water purification is membrane fouling. Fouling occurs when certain impurities in water are deposited on the surface of a memb..

A New Method For Anion Metathesis

vBackground Organic salts are essential reactants in a number of important applications, including the preparation of reaction media, catalysts, precatalysts, analytical materials, solvent, and sensor..

Highly Efficient and Specific Oxidation of Nucleic Acids with Dinuclear Copper Complexes

The present invention is related to a novel method for splitting nucleic acids at specific points on a complementary nucleic acid segment using a dinuclear copper-based compound of Formula I. Addition..

Abstract Tungstated Zirconia Nanocatalysts

Preparation of tungstated zirconia solid acid catalyst with enhanced activity Advantages . Enhanced activity relative to solid acid catalysts . Enhanced selectivity, thermal stability, and resis..

Method for Producing Tetrapodal Nanoparticles with High Selectivity

Large-scale production of tetrapodal CdSe nanoparticles Advantages . Method produces tetrapodal CdSe nanoparticles of uniform size with high selectivity . Production costs (relative to existing met..

Group IV monolithic column

In present chromatography products, silica based and organic polymers are used to fabricate monolithic columns. While some of these stationary phases have pH and temperature limitations, zirconia offe..

Temporally Addressable Biochemical Sensor Arrays

Chemical sensor arrays are low cost, compact, robust and versatile alternatives to large analytical tools and hence drive the need to rapidly fabricate reusable chemical sensor arrays for simultaneous..

Protein Imprinted Xerogels with Integrated Emission Sites (PIXIES)

Solution Processable n-Type polymers

Introduction Conjugated polymers and organic semiconductors promise great advances in electronics because of the benefits they offer over silicon, including being cheaper with less demanding manufactu..

Continuous Production of Microcellular Fibers

Introduction In microcellular plastic foams, inert gas is dissolved in thermoplastic under high pressure. The forced evacuation of this gas during processing creates pores (or cells) within the final ..

Microcellular Foaming of Cyclic Olefin Copolymer (COC)

Introduction Cyclic olefin copolymer (COC) is a commercially available thermoplastic. It possesses exceptional clarity in its natural form, similar to that of glass, and it has high moisture resistanc..

Methods for Detecting and Extracting Gold

Introduction Gold is found in various forms on earth. It can be found in rocks, ore deposits, eluvial deposits, alluvial deposits, placer deposits etc. Gold is also recovered from secondary sources su..

Programmable Generation and Transport of Droplets on Microscale Surface Texture Ratchets

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications. Currently, many laboratory processes can be combined on a single chip commonly only mill..

Selective Detection of Phosphoproteins

Introduction Mass spectrometry enrichment and detection of phosphoproteins is critical to cancer research and drug development, among many applications. In MALDI-TOF mass spectrometry, metal plates de..

Nanocellular Foaming of Ultra High Molecular Weight Polyethylene using Ultrasound

Introduction Ultra high molecular weight polyethylene (UHMWPE) is a thermoplastic consisting of molecules of incredibly long chains with molecular weights of several million. It has the highest impact..

Solution Processable n-Type polymers

Polymer Solar Cells using Self-Assembled Monolayer modified Zinc Oxide/Metal as Cathodes

Introduction Conjugated polymer-based organic solar cells are considered an essential source of inexpensive renewable energy due to their advantages of being fabricated by low-cost and large-area prin..

Continuous Production of Microcellular Fibers

Microcellular Foaming of Cyclic Olefin Copolymer (COC)

Method for the Preparation of SiC Nanorods

Summary A process has been developed to produce SiC nanorods in high yield with diameters <100 nm (typical diameters of 2-40 nanometers) and aspect ratios of 10-1000 nm. This method can be used to pro..

Selective Deposition of Cells in Microwells

Summary This invention is a method of selectively functionalizing indentations (such as wells or channels in microfluidic systems) or protrusions on a substrate such that, for example, cells selective..

Method and Apparatus for Fluid Dispersion

Summary The invention is a microfluidic device for focusing and/or breaking fluid sections and drops. The subject fluid flows in the device's central channel as the dispersing fluid flows in the two o..

Electrostatic Steering of Charged Droplets in Microfluidic Devices

Summary The invention consists of means of charging droplets and then using that charge to choose which channel a droplet will enter at a bifurcation. There is a need to have fast, accurate means o..

Method and Apparatus for Forming Multiple Emulsions

Summary Everyday emulsions have drops of one liquid dispersed in an immiscible continuous liquid. A multiple emulsion has immiscible droplets dispersed in drops dispersed in an immiscible continuous l..

Novel Peptide Therapeutic for Multiple Sclerosis

Summary Background: In Multiple Sclerosis, the hostâ€™s immune system (lead by T cells) attacks and destroys myelin basic protein, the principle component necessary for nerve transmission. Part a..

Mu Opioid Peptidomimetics: Lead Compounds for the Treatment of Pain

Summary Background: Although peptides have shown some promise in clinical trials as therapeutic agents, their success has largely been limited by several factors, including rapid degradation by peptid..

Novel Peptide Therapeutic for Multiple Sclerosis

Summary Background: In Multiple Sclerosis, the host immune system (lead by T cells) attacks and destroys myelin basic protein, the principle component necessary for nerve transmission. Part and parcel..

A Novel Class of HIV Therapeutics: Monoclonal Antibodies that Neutralize Previously Resistant HIV Primary Isolates

Summary Background: Molecular studies of the genomic organization of HIV-1 show that it encodes a number of genes common to all retroviruses, such as the gag, pol, and env genes. The env gene of HIV-1..

Antibody Purification

Summary Background: Monoclonal antibodies have become increasingly important for biomedical research and clinical therapeutics. The antibodies are used extensively in basic biomedical research, dia..

Deposition of nanoscale materials using structured surfaces

Summary The ability to precisely localize and control deposition of materials at the nanoscale is extremely important for a wide variety of emerging technologies. Many unique physical properties emerg..

Production of Digitized Stereoscopic Polarizing Images by Inkjet Printing

Summary The Technology The Stereo Imaging Research Group developed methods, materials and applications for stereoscopic hardcopy. The group's StereoJet process forms polarizing images by inkjet pri..

Production of Digitized Stereoscopic Polarizing Images by Inkjet Printing

Summary The Technology The Stereo Imaging Research Group developed methods, materials and applications for stereoscopic hardcopy. The group's StereoJet process forms polarizing images by inkjet pri..

Creating Nano-Wrinkles of Virtually any Design on the Surface of Polymers

Summary Creating Nano-Wrinkles of Virtually any Design on the Surface of Polymers Elevator pitch: A new method has been developed at Harvard to design and create virtually any type of nano-wrinkl..

General Approach to Large Area, Controlled Density, Aligned Films of Nanowires and Carbon Nanotubes via Bubble Expansion

Summary Background Central to many proposed electronic device-based applications of nanowires and carbon nanotubes is the development of methods that enable organization over large areas with controll..

Uniform Non-Spherical Colloidal Particles with Tunable Shapes

Summary Background: Non-spherical colloidal particles are useful in advanced applications beyond those that regular spherical colloidal particles exhibit. For example they are useful for modifying ..

Patterning of metals and metal compounds using ionotropic polymers

Summary Background: Patterning surfaces to create some function is a core technology propelling our technical society. The most important such technology, photolithography, is used to create IC chi..

Portable and Inexpensive Chemical and Biological Sensors

Summary The broadly tunable quantum cascade laser (QCL) described in this invention enables the production of a small, portable chemical and biological sensor that can detect a range of molecules with..

Microfabricated, Chip-Based, Low-Power Optical Tweezers

Summary Since they were first demonstrated over twenty years ago, optical tweezers have been widely used for the manipulation and measurement of many microscale particles, particularly in the biologic..

Microfluidic Platform for Constructing Tunable 3D Cellular Microenvironments for Performing Biologically Relevant Cell-Based Assays

Summary Markets/Needs Addressed: In vitro studies of living cells are commonly carried out in 2-dimensional (2D) systems involving cells grown in monolayers in glass or polystyrene Petri dishes. The ..

Deposition of nanoscale materials using structured surfaces

Transparent Conductor (formerly Zinc Oxyflouride)

Summary This invention embodies unique chemical vapor deposition (CVD) thin film compositions which reflect infrared radiation, transmit visible light, absorb ultraviolet radiation and conduct electri..

LHASA Software Program: Chemical Synthesis Analysis

Summary The computer program LHASA (an acronym for Logic and Heuristics Applied to Synthetic Analysis), which has been under continuous development at Harvard and various collaborating universities fo..

Fabrication of Carbon Microstructures

Summary This invention provides a convenient, inexpensive, rapid, and reproducible method for making high-carbon solid structures on the micro scale (dimensions of less than 2 mm, less than 100 nm, or..

Vapor Deposition of Silica Nanolaminates

Summary This invention concerns a very efficient atomic layer deposition (ALD) method to make extremely smooth and highly conformal silica thin films with excellent step coverage. As microelectronic c..

Microfluidic Arrays for Multiplex Detection of Analyts

Summary This invention is a microfluidic array apparatus and a method of performing multiple analyses on multiple samples simultaneously, utilizing nanoliter volumes of reagents. It has two embodiment..

Scaleable Hydrogen Production via Bioengineered Yeast Systems

Summary A new synthetic biology approach is proposed for producing hydrogen from bioengineered yeast strains. The invention applies aggressive engineering of metabolic pathways and reducing complexes ..

Specific Targeting of Cell Division (and Cancer): Small molecule inhibitors of Eg5 Hold Potential for Enhanced Safety

Summary Prof. Mitchisonâ€™s group at Harvard was the first to show, very elegantly, that it is possible to specifically target cell division proteins other than tubulin by using a small molecule,..

Novel Anti-CMV Small Molecules

Summary Five structurally diverse small molecules have been discovered that inhibit human cytomegalovirus (CMV) replication with sub- to low micro-molar potency and at concentrations of up to 500-fold..

Novel Clinical Stage Treatments for Epilepsy and Pain

Summary The principal investigator has discovered that Huperzine A (HupA) is characterized by extremely potent therapeutic activity against epilepsy and chronic pain. HupA was tested in a formalin mod..

Transparent Conductor (formerly Zinc Oxyflouride)

DEREK Software

Summary The computer program DEREK (an acronym for Deductive Estimation of Risk from Existing Knowledge) is designed to assist chemists and toxicologists in predicting likely areas of possible toxicol..

Extended Nitride Material Comprising C2N and Formation Method

Summary This invention includes a novel carbon nitride material and a method for its production. Carbon nitride has been shown to be harder than diamond as well as a better heat conductor. Pulsed lase..

Fabrication of Carbon Microstructures

Method for the Preparation of SiC Nanorods

HBPA Photoaffinity Probe

Summary This invention describes a photolabeling reagent p-(4-hydroxybenzoyl)phenylalanine (HBPA) which overcomes many difficulties associated with BPA. Patent protection includes this compound's synt..

Liquid Precursors for Formation of Metal Oxides

Summary Films of metal oxides have been deposited from vaporized precursor mixtures of metal beta-diketonates and, optionally, oxygen or other sources of oxygen. For example, a liquid mixture formed o..

Vapor Source for Chemical Vapor Deposition

Summary A novel apparatus has been developed to turn liquids into vapors for use in chemical vapor deposition. It employs a high-frequency ultrasonic plate to break the liquid into tiny droplets and a..

On Bead Tagging and Decoding for Combinatorial Synthesis

Summary Pharmaceutical drug discovery has been greatly impacted by the development of novel approaches to the rapid synthesis of novel compounds, including combinatorial synthesis approaches. A common..

Liquid Precursor for Formation of Materials Containing Alkali Metals

Summary Volatile liquid precursors (reagents) have been developed for the formation of alkali metal-containing materials using chemical vapor deposition (CVD), spray coating, spin coating or sol-gel d..

Techniques for high yield synthesis of macrocyclic compounds

Summary Many useful pharmaceuticals, including natural products, have a macrocyclic structure that can be a challenge when exploring synthesis methods. The Walsh Laboratory has discovered a new proces..

Vapor Deposition of Silica Nanolaminates

Method of Creating Self-Assembled, Selectively-Permeable Colloidosome Structures

Summary Colloidosomes are spherical shells of micron-sized particles made by the simple technique of self-assembly onto emulsion droplets. These hollow, elastic capsules are ideal for efficiently enca..

Selective Deposition of Cells in Microwells

Microfluidic Arrays for Multiplex Detection of Analyts

Production of Digitized Stereoscopic Polarizing Images by Inkjet Printing

Summary The Technology The Stereo Imaging Research Group developed methods, materials and applications for stereoscopic hardcopy. The group's StereoJet process forms polarizing images by inkjet pri..

Highly Conformal Tungsten Nitride Thin Films

Summary The invention describes a method of producing a uniform, smooth and conformal coating of tungsten nitride, synthesized by atomic layer deposition (ALD). The silver-colored coating (or film) is..

Alteration of Surface Affinities

Summary This invention claims a method for using a pulse of current in an electrochemical microdevice to change a surface from one that resists the adsorption of proteins and cells to one that promot..

Atomic Layer Deposition Using Metal Amidinates

Summary This invention relates to materials and processes for d eposition of conformal films containing metals on solid substrates. Examples include copper, cobalt and iron metals or their oxides or n..

Using Electro-magnetically Induced Transparency in Photonic Crystal Cavities to

Summary This invention describes a photonic crystal system which uses electro-magnetically induced transparency (EIT) as the non-linear medium in photonic crystal cavities to obtain devices of unprece..

Method and Apparatus for Fluid Dispersion

Electrostatic Steering of Charged Droplets in Microfluidic Devices

Summary The invention consists of means of charging droplets and then using that charge to choose which channel a droplet will enter at a bifurcation. There is a need to have fast, accurate means o..

Method and Apparatus for Forming Multiple Emulsions

Engineering 3D and Free Standing Tissue Structures

Summary Background: Efforts to build biosynthetic materials or engineered tissues that recapitulate the structure-function relationships of natural processes often fail because of an inability to repl..

Antibody Purification

Summary Background: Monoclonal antibodies have become increasingly important for biomedical research and clinical therapeutics. The antibodies are used extensively in basic biomedical research, dia..

Novel Surfactants for Stabilizing Emulsions of Water or Hydrocarbon Oil-Based Droplets in a Fluorocarbon Oil Continuous Phase

Summary Emulsionsâ€”dispersions of two immiscible fluidsâ€”have many applications in industry and everyday life. These range from paints, to crop protection, chemical synthesis, and producti..

"MoleProbe": A Real-Time Molecular Diagnostic Device

Summary A novel engineering method for generation of freestanding 2-D and 3-D tissue structures. Biopolymers (proteins, carbohydrates, lipids, nucleic acids or combinations thereof) are deposited onto..

Complex particle fabrication by chemically-directed contact electrification

Summary Background: Micro- and nanoscale particles are an area of intense research and commercial activity. They have many potential uses, for example in drug delivery, electronics and material app..

Patterning of metals and metal compounds using ionotropic polymers

Summary Background: Patterning surfaces to create some function is a core technology propelling our technical society. The most important such technology, photolithography, is used to create IC chi..

Native Anti-corrosion Coatings for Metals

Summary The need: Corrosion of metals hamper the performance and safety of products ranging from medical implants to large-scale naval vessels, aircraft, bridges, and oil pipeline structures. A 2002 s..

Systems and Methods for Assembly via Contact Electrification

Summary Taking advantage of a newly discovered mechanism for contact electrification of insulators the inventors have invented a new method of patterning insulator surfaces with particles. By assembli..

A novel bioplastic

Summary A novel bioplastic, poly ((3R,5R)-3,5-dihydroxyhexanoic acid (poly(3,5-DHH), has been discovered. This molecule may be manufactured biosynthetically and offers significant advantages over curr..

Deposition of nanoscale materials using structured surfaces

Novel Synthetic Mechanism to b-Lactone and Analogs: Lead Compounds for the Treatment of Proteasome-Related Diseases

Summary Background: Proteasome inhibition offers considerable promise in the therapy of a number of types of diseases, such as cancer and neurodegenerative diseases. One such proteasome inhibtor, Velc..

Improved Method of Expression Cloning

Summary The human genome will soon be completely sequenced, presenting a vast new array of targets against which pharmaceutical agents can potentially be designed. However, to capitalize on this new i..

HBPA Photoaffinity Probe

Bilins as anticancer agents

Summary A remarkable discovery at Harvard Medical School has led to the recognition that a naturally-occurring small molecule and analogs thereof possess potent anticancer properties through their abi..

Inhibitors of Protein-Processivity Factor

Summary Harvard investigators have discovered that Pol interacts with a processivity factor at a site that is distinct from sites of normal interaction between known Pol family members and other cellu..

Method of Detecting Compounds Utilizing Genetically Modified Lambdoid Bacterioph

Summary This invention describes a method to detet a molecule of interest in a given solution, and a method of selecting or screening for cell lines that can continuously produce desired compounds. Th..

Nonhomologous Random Recombination of Nucleic Acids (Nucleic Acid Shuffling)

Summary This invention comprises methods for non-homologous random recombination (NRR) of nucleic acids, and their use to develop and select nucleic acids or polypeptides with novel structure and func..

Modular Conditional Knockout: Precise Temporal Control of Protein Degradation in Living Cells

Summary Polyubiquitinated proteins in eukaryotes are directed to the proteasome for degradation. It is generally accepted that proteasome-mediated proteolysis depends strictly upon ubiquitination, as ..

Transformation of a Semiconducting Nanowire into a Conducting Nanowire in a Controllable Way

Summary This invention describes a nanowire that changes from a semiconductor to a conductor along its length and a method of making it. The method involves reacting a semiconductor nanowire with a me..

Affinity grids in preparing single particle specimens for Electron Microscopy

Summary Immobilized metal affinity chromatography has been used extensively to isolate macromolecular complexes for structural studies. This is facilitated by the high affinity interaction between a s..

Crosslinkable Hole Transporting Materials for Organic Lightemitting Diodes

Introduction High-performance organic or polymer light-emitting diodes comprise multilayer configurations having hole-transporting, emissive and electron-transporting layers to balance the injection a..

Nanocomposite Photovoltaic Cells

Introduction Photovoltaic cells based on polymer semiconductors are of great interest as a low cost approach to solar energy conversion into electricity. The most efficient polymer solar cells are bas..

Programmable Generation and Transport of Droplets on Microscale Surface Texture Ratchets

Fabrication of Gold Nanocages and Cubic Nanoframes for Biomedical Treatment through Etching Nanoboxes

Introduction Because of their small sizes and unique properties, nanomaterials are finding widespread use in studying complex biological systems. Gold nanostructures have been the subject of intensive..

Production of Palladium Nanostructures with Shape Selection by Adding Bromide

Introduction Single-crystal, one-dimensional nanostructures of palladium are attractive as interconnects for fabricating nanoscale electronic devices. Polycrystalline, mesoscopic wires made of palladi..

Copper Chloride-mediated Synthesis of Silver Nanowires

Introduction Owing to the high electrical and thermal conductivity of bulk silver, the synthesis of Ag nanowires has been and continues to be an area of active research. The properties and application..

Electrospray Evaporative Spray Cooling (EESC)

Introduction As electronic devices get increasingly more powerful and more compact, there are an increasing number of semiconductor components that emit an increasing amount of heat. In order to ensur..

Carbon Nanotubes by Electrospinning with a Polyelectrolyte and Vapor Deposition Polymerization

Introduction Ever since the discovery of carbon nanotubes they attracted a great deal of attention due to the myriad of possible applications, such as in fuel cells, lithium-ion batteries, and superca..

Gold Vision

Introduction A neuron or group of neurons that senses or receives light within the eye is known as a photoreceptor. Damaged or diseased photoreceptors lead to impaired vision or blindness. Local stimu..

Integrated Platform for Chemical Profiling of Ultrasmall Subcellular Compartments from a Single Cell

Introduction The ability to analyze biological and chemical activity at the subcellular level is limited by the tools that are currently available. Typically a choice between the spatial fidelity of i..

Novel Gadolinium nanoparticles for Magnetic Resonance Lymphatic Imaging

Introduction Gadolinium (Gd3+) is chelated with diethylenentriaminepentaacetyl (DTPA) to provide contrast in magnetic resonance (MR) imaging to identify pathogenic tissues. Unfortunately, the Gd3+-DTP..

Nanocellular Foaming of Ultra High Molecular Weight Polyethylene using Ultrasound

Production of Palladium Nanostructures with Shape Selection by Adding Bromide

Copper Chloride-mediated Synthesis of Silver Nanowires

Gold Vision

A Microfluidic Device and Methodology for Rapid, Quantitative Determination of Analyte Concentration in a Fluid Sample

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, especially for biosensors and environmental monitoring. One recent area of interest is p..

Platelet Clotting Force Array

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, such as point-of-care diagnostic devices. These microscale diagnostic platforms will ena..

Programmable Generation and Transport of Droplets on Microscale Surface Texture Ratchets

Signal Amplification Method for SPR-based Chemical Detection

Introduction Surface plasma resonance (SPR) is a general spectroscopic method for sensing refractive index changes near the surface of a metal film. Its sensitivity to these changes provides a versati..

3-D Tissue Culture Chamber

Introduction Many of the seminal findings in cell and molecular biology have come from cultures of cells grown in two dimensions but the limitations of biology in just 2D are becoming clear. Cells in ..

Platelet Clotting Force Array

Preparative Separation of Mixtures by Mass Spectrometry

Introduction With the average development cost for new pharmaceutical products in the hundreds of millions and continuing to increase, there is a pressing need to identify successful therapeutic compo..

Design of Thermal Interface Material Based on High Temperature Shape Memory Alloy for Connecting Two Thermoelectric Legs

Introduction Efficient heat management is crucial for electronics to optimize performance and to avoid premature component deterioration. An area of primary concern is at the interface of adjoining th..

Design of Active Materials and Structures based on Composites of Shape Memory Alloy and Shape Memory Polymer

Introduction Shape memory alloys (SMA) and shape memory polymers (SMP) have shown tremendous promise for a wide variety of applications because of their ability to “remember” a previous state when..

Method of Detecting, Characterizing, and Quantifying Bulk, Light- Element Materials Using High-Energy, Penetrating X-Rays

Introduction X-rays have long been used in the characterization of a wide variety of materials. However, conventional techniques for dealing with light-element (or low-Z) materials, such as those cont..

Streptavidin Mutants having Secondary Functional Domains

Introduction Streptavidin, a protein produced by Streptomyces avidinii, forms an extremely strong and specific non-covalent complex with the water soluble vitamin biotin. This binding affinity is so s..

Precision coating of macromolecules on Surfaces

Introduction Production of chemically modified surfaces by ion deposition allows for unique chemistries on those surfaces, providing functionalities that are critical to medical devices such as stents..

Shockwave Reactor

Introduction Ethylene is a commercially important chemical with many applications, and it is especially important as a building block for other, more complex molecules. It is typically made by crackin..

Novel Compound Semiconductor Use as a Buffer Layer for Controlled Oxide Growth on Silicon

Introduction An area of research that has gained increasing importance in recent years is the controlled growth of oxides other than SiO2 on silicon. Technology description Researchers at the UW have ..

Electroactive Polymer Using Shape Memory Alloy

Introduction Shape memory polymers have shown tremendous promise for a wide variety of applications for their ability to “remember” a previous state when heated. Unfortunately, they have been slow..

Droplet Compartmentalization for Chemical Separations and On-Line Sampling

Introduction The ability to separate complex mixtures of chemicals and biomolecules is an important component of any chemical synthesis or biological processing. To date, there is no technology availa..

Copper Chloride-mediated Synthesis of Silver Nanowires

Catch and Release Method for Charged Particle Concentration

Introduction Cell separation in a microfluidic device can be difficult at times. One difficulty researchers face is the ability to capture and separate charged particles when carried in an aqueous sol..

A Method and Design for Performing Rapid Parallel Microfluidic Molecular Affinity Assays

Introduction Point-of-care diagnostic testing, or testing performed at the patient bedside, allows physicians to diagnose patients more rapidly than traditional laboratory-based testing. Rapid results..

Method for Deconvolving Single-Molecule Intensity Distributions for Quantitative Biological Measurements

Introduction Fluorescence microscopy images of cells often contain puncta, or clusters of fluorescence signal. To measure the concentration of labeled proteins in a puncta, calibration typically needs..

Carbon Nanotubes by Electrospinning with a Polyelectrolyte and Vapor Deposition Polymerization

Advanced Biomimetic Surfaces for Surface-Enhanced Raman Biomimetic Surfaces for Surface-Enhanced Raman

Introduction Raman spectroscopy characterizes molecules by their Raman scattering. As incoming light scatters off a molecule, most does so elastically, neither gaining nor losing energy, and this is k..

Advanced Biomimetic Surfaces for Surface-Enhanced Raman Biomimetic Surfaces for Surface-Enhanced Raman

Air-Stable p-Type Semiconducting Polymers

Inductive Salinometer with Data Logging Capabilities and Toroidal Sensor

Introduction Salinity levels in seawater are not constant and can vary dramatically both temporally and spatially due to phenomena such as temperature, precipitation, deep-water upwelling, and tidal a..

Epoxide Initiators to Produce Hydroxyl-Functionalized Polyolefins by Carbocationic Polymerization

University of Western Ontario researchers have successfully developed a technology that produces Telechelic primary hydroxyl-functionalized polyisobutylene (PIB-OH) in a one step one pot synthesis pro..

Hydrophobic Powder Paints

Novel powder paints demonstrated to provide super-hydrophobic (Contact Angle > 160º) properties Description Description of the Invention Novel powder paints have been demonstrated to provide..

An Integrated, Continuous Fluidized Bed Ion Exchange System

A breakthrough in the area of ion exchange chromatography, as a highly efficient substitute for the packed bed and fluidized bed ion exchange processes. Description Background The separation ..

Novel Process for the Removal of Sulfur from Fuels

A novel process for removing sulfur from a hydrocarbon stream involving catalytic dehydrosulfidation. Description Background Federal regulations in both Canada and the U.S. have dictated that ..

Method to Enhance Oil Recovery from Fractured Carbonate Reservoirs

An environmentally-friendly method to recover heavy oil/bitumen from fractured carbonates, which contain about 60% of the world's oil reserves. The method potentially allows for much faster recovery a..

EXCIPLEX ™A HIGHLY SENSITIVE NUCLEIC ACID FLUORESCENT DETECTION SYSTEM

BACKGROUND Conventional fluorescent dyes used in nucleic acid detection methods suffer from a number of limitations. High backgrounds result in false positives and a reduction in sensitivity. The smal..

MONOMER FOR ‘ONE-PART’ CROSSLINKABLE WATER-BORNE COATINGS (HESS)

BACKGROUND Water-borne latex-based coatings have been in commercial use for well over five decades. For chemical and polymer suppliers, the inherently easier and safer manufacturing/ handling associat..

pH modified UV treatment of water pesticidal and pharmaceutical

The Invention The invention consists of introducing a pH influenced polychromatic ultra-violet (UV) photolysis process for disinfection of water contaminated by several organic components (alone or i..

Use of Photosensitized Epon Epoxy Resin 1002F for MEMS and BioMEMS Applications

Background: Microelectrical-mechanical systems (MEMS) are miniature mechanical devices intended to perform non-electronic functions such as sensing or actuation. These devices are typically built fro..

A Chemical Compound with Possible p53 Cancer Mutant Rescue Activity

Background: Mutants of the tumor suppressor protein are frequently found in human cancers. About three quarters of them have a single amino acid change in the core domain of p53 that is needed to bin..

One-Step Direct Synthesis of LaPO4

Background: Monazite is an important ceramic material for several potential applications including composite ceramics, machineable ceramics, nuclear waste storage, fluorescent materials, electrochemi..

A Microfabrication Process for Vertical Microelectrodes inside Polymer Microchannels

Background: For microfluidic applications, different electrodes inside the microfluidic channels may be patterned by metal evaporation methods such as thermal evaporation, electric beam evaporation, ..

A New PET Radiotracer for Serotonin 5HT1A Receptors

Background: Serotonin 5-HT1A receptors are implicated in Alzheimers disease, dementia, anxiety, schizophrenia, and depression, and significant efforts have been undertaken to develop various compound..

New Protein Resistant and Biodegradable Biopolymer

Background: The ability to resist nonspecific protein adsorption (protein resistance) is an indicator of a material's biological inertness or biocompatibility. Protein resistant biomaterials such as ..

High-Isolation Tunable MEMS Capacitive Switch

Background: For a typical MEMS switch, the resonant frequency is around 20 to 30 GHz which can not be employed by commercial wireless systems operating at a frequency band of 2 to 8 GHz. This resonan..

Depth Profiling of the Skin Structure In Vivo

University researchers have developed a photoacoustic probe contained within a handpiece for use in contact with the skin. The laser pulses generate acoustic waves at the subsurface absorption sites. ..

Fabrication Method for Polymer Thin Films

University researchers have developed a method that allows for the synthesis of a wide variety of polymer thin films, the fabrication method of which can be combined with photolithography to create su..

Molecular Imprinting for the Recognition of Peptides in Aqueous Solution

Molecular imprinting is a process for synthesizing materials that contain highly specific recognition sites for smaller molecules. Today, molecular imprinting is used for many purposes, including the ..

Aluminum - Lithium Alloy Metal Matrix Composites

For high temperature aerospace application, Ti alloys are often utilized to produce structural parts. However, the cost has often been the drawback. Finding an alternative has motivated the developmen..

Emulsified Zero-Valent Iron (EZVI) (KSC-12246)

Emulsified Zero-Valent Iron is a versatile technology that can be used at many of these locations. Applicable sites may include: dye and paint manufacturers;dry cleaners; chemical manufacturers; metal..

Hydrocarbon Oxidation for Manufacturing Chemicals

APPLICATION OF TECHNOLOGY: Chemical manufacturing Hydrocarbon oxidation ADVANTAGES: Works at ambient temperature Highly selective Energy-efficient process Environmentally benign ABSTRACT: Hei..

Using liquid desiccant as a regenerable filter for capturing and deactivating contaminants

A method, and systems for implementing such method, for purifying and conditioning air of weaponized contaminants. The method includes wetting a filter packing media with a salt-based liquid desiccant..

Device and method of positionally accurate implantation of individual particles in a substrate surface

A device and a method for positionally accurate implantation of individual particles in a substrate surface (1a) are described. A diaphragm for a particle beam to be directed onto the substrate surfac..

Biological Production of Polymer Monomers

EJIB-2541 APPLICATIONS OF TECHNOLOGY: Producing a wide variety dicarboxylic acids for the manufacture of commercial polymers, e.g. polyesters, polyamides, polyurethanes ADVANTAGES: Starting m..

Microfluidic device forming enhanced spatial and temporal gradients

Microfluidic device improving on current chemical gradient-generation designs in the forming of spatial and temporal gradients in a compact structure TECH FIELD(S) Microfluidic devices FEATUR..

Device for Controlled Placement of Effluents from Mechanically or Electrically Driven Separations

TECH FIELD(S) Analytical Chemistry, Mass Spectrometry, Proteomics FEATURES The analysis of samples utilizing analytical chemistry techniques frequently requires the samples to be subjected to a ..

Process for Thermo Catalytic Cracking (TCC) of heavy oils feeds to increase production of light olefins (Ethylene-Propylene) at low Temperature

Solution / invention summary : TCC Process is operated in existing steam cracking reactors and uses a novel catalyst material to increase the production of Ethylene-Propylene at a lower cracking temp..

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