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SEROTONIN TRANSPORTER GENE AND TREAMENT OF ALCOHOLISM

The gene responsible for encoding SERT has a functional polymorphism at the 5'-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a..

Use of S-Nitrosothiol Signaling to Treat Disordered Control of Breathing

The present invention is directed to a method of treating disordered control of breathing including the treatment of apnea and hypoventilation associated with congenital or acquired brain stem abnorma..

COMBINATION OF HGF INHIBITOR AND PTEN AGONIST TO TREAT CANCER

The present invention is directed toward a method of treating cancer by administering to a patient an inhibitor of Hepatocyte Growth Factor and an agonist of PTEN.

Method and System For Fusing a Spinal Region

A method and system for fusing a region in the spine involve the use of at least one guide tube to pass instruments and substances into the spinal region in a minimally invasive manner. In the preferr..

COMPOSITIONS AND METHODS FOR TREATMENT OF LEUKEMIA

The invention relates generally to effective treatment leukemia. In particular, the present invention provides compositions and methods to inhibit the interaction of menin with MLL and MLL-fusion onco..

Use of pramipexole to treat amyotrophic lateral sclerosis

The present invention is directed to compositions comprising pramipexole and the use of such compositions treat neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). As shown in Fig...

Inhibiting CAV3 isoforms and the delta25B splice varients for the diagnosis and treatment of cancer

The present application is directed to an antibody that specifically binds to a Cav3 isoform or its '25 splicing variants thereof.

L- ODDC PRODRUGS FOR CANCER

The main drawback in the use of most nucleoside anticancer agents originates from their hydrophilic nature, of which property requires a high and frequent dosage for an intravenous administration. Unl..

HYBRIDOMA CELL LINES AND MONOCLONAL ANTIBODIES RECOGNIZING ANTHROSE SACCHARIDE OF BACILLUS ANTHRACIS

The present invention includes hybridoma cell lines and monoclonal antibodies that bind to the anthrose tetrasaccharide of Bacillus anthracis and methods using said antibodies.

ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE

Disclosed herein are antimicrobial compositions, kits, and articles of manufacture. Further disclosed herein are methods for treating surfaces, including tissue, inter alia, wounds, with the disclosed..

No-modified hemoglobins and uses therefor

Nitrosylhemoglobin can be produced by introducing gaseous NO into an aqueous solution of hemoglobin. It has been demonstrated that nitrosylhemoglobin in aqueous solution can be converted to SNO-hemogl..

Dual Specific Immunotoxin for Brain Tumor Therapy

We tested the in vitro and in vivo efficacy of a recombinant bispecific immunotoxin that recognizes both EGFRwt and tumor-specific EGFRvIII receptors. A single chain antibody was cloned from a hybrido..

Anti-Tumor Antibodies

Chondroition sulfate proteoglycans represent excellent targets for anti-tumor immunotherapy. Antibodies which target such proteoglycans can be used alone, in combinations, armed with a cytotoxic paylo..

VACCINE VECTORS

The present invention relates, in general, to recombinant viral constructs expressing a protective antigen and to vaccine compositions comprising same. The invention further relates to a method of ind..

Inhibiting Smad signaling promotes neuron regeneration

Regeneration of a lesioned CNS axon of a mature neuron, determined to be subject to regeneration inhibition by Smad2/3 signaling, is promoted by contacting the neuron with an inhibitor of Smad2/3 sign..

METHOD FOR AUGMENTING THE EFFECTS OF SEROTONIN REUPTAKE INHIBITORS

A method of treating a subject for a serotonergic neurotransmission dysregulation disorder, comprises administering the subject a serotonin enhancer (e.g., a serotonin reuptake inhibitor) in an amount..

COMPOSITIONS AND METHODS FOR THE TREATMENT OF SEBORRHEA

Methods and compositions are provided for treating dermatological diseases, disorders, and pathologies, including seborrheic dermatitis, in a subject in need thereof. In some embodiments, methods are ..

COMPOSITIONS FOR TISSUE REPAIR/REGENERATION

The invention provides compositions and methods for cardiac repair and/or regeneration of tissues such as myocardium.

ANTI-CD19 ANTIBODY THERAPY FOR AUTOIMMUNE DISEASE

The invention relates to immunotherapeutic compositions and methods for the treatment of autoimmune diseases and disorders in human subjects using therapeutic antibodies that bind to the human CD19 an..

CHRONIC LYMPHOCYTIC LEUKEMIA PROGNOSIS AND TREATMENT

Provided herein are methods for identifying a subject afflicted with chronic lymphocytic leukemia who is responsive to treatment with a chemotherapeutic agent by detecting the presence or absence of a..

ANTI-CD19 ANTIBODY THERAPY FOR TRANSPLANTATION

The invention relates to immunotherapeutic compositions and methods for the treatment and prevention of GVHD, humoral rejection, and post-transplantation lymphoproliferative disorder in human subjects..

COMPOSITIONS AND METHODS FOR TREATING HAIR LOSS USING NON-NATURALLY OCCURRING PROSTAGLANDINS

A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse h..

Methods and Compositions to Identify Increased Risk of Breast Cancer by Detection of CPG Island Methylator Phenotype (CIMP)

The present invention is directed to kits and methods for identifying a female subject as having an increased risk of developing breast cancer, comprising detecting a CPG island methylator phenotype (..

CANCER THERAPY

PROBLEM TO BE SOLVED: To provide cancer therapy. ; SOLUTION: A method for preventing or treating cancer is provided. In the method, low molecular weight antioxidants [e.g., mimetics of superoxide dism..

REAGENT FOR AUTOIMMUNE DISEASE AND TREATMENT

PROBLEM TO BE SOLVED: To provide a reagent for the treatment of autoimmune diseases and a method. ; SOLUTION: This invention relates to a treatment method using an anti-CD22 monoclonal antibody having..

XANTHINE DERIVATIVES FOR THE TREATMENT OF VASCULAR DEPRESSION

Methods and compositions are provided for treating vascular depression. The methods involve administering to a subject in need thereof a xanthine derivative in a therapeutically effective amount to tr..

METHODS OF SUBCLASSIFICATION OF DUCTAL CARCINOMA OF THE BREAST

Provided herein are methods of determining the aggressiveness or indolence of a ductal carcinoma in situ lesion. Also provided are methods of developing treatment plans for subjects with a ductal carc..

PREVENTION OF FLAP NECROSIS IN PLASTIC SURGERY

PROBLEM TO BE SOLVED: To provide a method for resolving or preventing vasoconstriction and preventing depletion of blood flow or restoring blood flow in a pedicle flap or any other microsurgery. ; SOL..

Peripheral Reticular Pigmentary Change and Age-Related Macular Degeneration

Examination of 956 age-related macular degeneration cases showed that the complement factor H variant (Y402H, C allele at rs1061170) increases risk for the development of peripheral reticular pigmenta..

Implants with membrane diffusion controlled active ingredient release

Implant having a structure for implantation in a human or animal body, comprises implant base body, primer layer applied at least partially to the surface of the implant, active ingredient layer consi..

STABILIZATION OF CELLS BY IONIC LIQUIDS

The present invention relates to the use of ionic liquids and/or compatible solutes for storing and stabilizing eukaryotic cells, above all blood cells such as leukocytes, platelets, or erythrocytes. ..

IMPLANT AND BONE SCREW HAVING INTERLOCKING CAMS

The invention relates to a fixation device for bones, consisting of an implant (1; 11), having at least one through hole (2; 12), to be fastened to the bone, and of at least one bone screw (3; 13) to ..

USE OF PLANT EXTRACTS COMPRISING POLYPHENOL FOR TREATING ADIPOSITY AND DIABETES MELLITUS TYPE 2

The present invention relates to the use of plant extracts comprising polyphenol for treating adiposity and diabetes mellitus type 2. The extracts comprise specific polyphenol compounds, in particular..

BIOEQUIVALENCE DIALYSIS

The present invention relates to a method for treating blood disorders and blood disorders compensation. This includes steps in which one blood or blood plasma of a patient outside the body brings wit..

Combination of an antibody and a bacterium, which expresses Fc-receptors or proteins, which bind the light chain of an antibody, useful for the treatment of tumors and their precursors, preferably col

Combination of at least one antibody and a bacterium, which expresses Fc-receptors or proteins, which bind the light chain of an antibody, is claimed, where at least one antibody is bound via its Fc-r..

BIOEQUIVALENCE DIALYSIS

The present invention relates to a method for treating blood composition disorders and blood function disorders. Said method comprises steps, in which blood or blood plasma of a patient is brought int..

USE OF OPIOIDS OR OPIOID MIMETICS FOR THE TREATMENT OF RESISTANT CANCER PATIENTS

The use of opioids or opioid mimetics is suggested for the manufacture of a medicament for the treatment of resistant cancer patients.

INHIBITING GSNOR

Treatment of myocardial infarction to reduce infarct size and organogenesis is provided by administration of agents selected from the group consisting of:

METHOD OF PROVIDING NEUROPROTECTION USING SUBSTITUTED PORPHYRINS

Described herein are methods of treating ischemic injury comprising administering to a subject in need thereof a therapeutically effective amount of a substituted porphyrin compound. Also disclosed ar..

3,28-DISUBSTITUTED BETULINIC ACID DERIVATIVES AS ANTI-HIV AGENTS

Compounds according to Formula (I) are described along with compositions containing the same and methods of use thereof for the treatment of viral infections.

METHODS OF TREATING LUNG DISEASE AND OTHER INFLAMMATORY DISEASES

A method of treating an inflammatory disease in a subject in need thereof is carried out by administering the subject a gastrin-releasing peptide (GRP) inhibitor in a treatment effective amount. Suita..

PREDICTING CORONARY ARTERY DISEASE AND RISK OF CARDIOVASCULAR EVENTS

Methods of assessing the risk of cardiovascular disease in a subject by detecting the level of at least one metabolite in a sample from the subject are disclosed herein. The level of the metabolite is..

PREVENTION OF RECEPTOR DESENSITIZATION

PROBLEM TO BE SOLVED: To provide a method for treatment of diseases relating to G protein receptor kinase activity or patients under pathological conditions of the same. ; SOLUTION: The desensitizatio..

METHODS AND COMPOSITIONS FOR REGULATING HDAC6 ACTIVITY

The present invention provides methods and compositions for inhibiting Hsp90 activity in a cell, comprising contacting the cell with an inhibitor of histone deacetylase 6 (HDAC6)

Treatment of glycogen storage disease type II

Methods of treating glycogen storage disease type II, by administering acid alpha -glucosidase, are described, as are compositions for use in treatment of glycogen storage disease type II.

COMPOSITIONS AND METHODS FOR MODULATING S-NITROSOGLUTHIONE REDUCTASE

Disclosed herein are methods and compositions for modulating the levels and/or activity of S-nitrosoglutathione reductase (GSNOR) in vivo or in vitro. Specifically disclosed are GSNOR deletion constru..

USE OF HASF AS A PROTECTIVE AGENT AGAINST ISCHEMIC TISSUE DAMAGE

A method of inducing a protective response against ischemic tissue damage is carried out by administering to subject a composition comprising an HASF polypeptide. The composition is administered prior..

NEUROACTIVE STEROID COMPOSITIONS AND METHODS OF USE THEREFOR

Provided are methods for ameliorating a symptom of a neuropsychiatric disorder in a subject. Also provided are methods for ameliorating at least one physical symptom or at least one psychological symp..

COMPOSITIONS AND METHODS FOR PROMOTING NASAL PATENCY AND TREATING NEUROGENIC BLADDER USING PROSTAGLANDINS

The invention provides methods for maintaining or promoting patency (e.g., nasal patency) comprising administering to a subject in need thereof an effective amount of at least one prostaglandin F anal..

Forming Iron Nitrosyl Hemoglobin

Contrary to current opinion that nitrite in general oxidizes hemoglobin with elimination of active nitric oxide, deoxygenated hemoglobin reacts with low concentration inorganic nitrite to produce very..

METHOD OF TREATING GLYCOGEN STORAGE DISEASE

The present invention relates, in general, to Glycogen Storage Disease and, in particular, to a method of treating Glycogen Storage Disease-type-III and to compounds and compositions suitable for use ..

IMPROVED DEVICE AND METHOD FOR DELIVERY OF A MEDICAMENT

The disclosure relates to an improved method of enhancing nicotine concentrations in a gaseous carrier. The methods are adaptable to the delivery of nicotine for therapeutic effect in various diseases..

TREATMENT OF WNT/FRIZZLED-RELATED DISEASES

Methods of treating Wnt/Frizzled-related diseases, comprising administering niclosamide compounds are provided. Methods of predicting whether a disease will respond to treatment with a niclosamide com..

SMOOTHENED RECEPTOR MODULATORS

The present invention relates, in general, to the Smoothened receptor and, in particular, to a method of modulating Smoothened receptor activity and to compounds and compositions suitable for use in s..

COMPOSITIONS AND METHODS FOR INHIBITING HAIR GROWTH

A method for inhibiting hair growth in mammals using compositions containing FP receptor antagonists (e.g., prostaglandin F analogs that are block activation of the FP receptor). The compositions can ..

USE OF AN AGENT THAT RESTORES TISSUE PERFUSION AND OXYGENATION

The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated ..

Inhibition of HIF-1 activation for anti-tumor and anti-inflammatory responses

The presently disclosed subject matter generally relates to methods and compositions for inhibiting the expression and/or activation of hypoxia-inducible factor 1 (HIF-1) genes in a cancer cell, tissu..

Compositions and Methods for the Treatment of Radioresistant Glioma Stem Cells

Compositions and uses of gamma secretase inhibitors (GSIs) for the treatment and inhibition of gliomas in subjects in need thereof are provided. Methods for administering gamma secretase inhibitors in..

STEM CELL DERIVED FACTORS FOR TREATING PATHOLOGIC CONDITIONS

A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic condtions.

Substituted porphyrins and their therapeutic use

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby proc..

NOVEL MEDICAL USES FOR NO AND NO DONOR COMPOUNDS

A body part is preserved using nitric oxide and/or a nitric oxide donor that does not directly release nitric oxide or a red blood cell nitrosylating agent, preferably ethyl nitrite to facilitate oxyg..

INHIBITION OF INTER-ALPHA TRYPSIN INHIBITOR FOR THE TREATMENT OF AIRWAY DISEASE

It is disclosed herein that blockade of inter-alpha-trypsin inhibitor (IaI) prevents the development of airway hyperresponsiveness in animal models of asthma and chronic obstructive pulmonary disease...

METHODS AND COMPOSITIONS FOR TREATING URINARY TRACT INFECTIONS USING AGENTS THAT MIMIC OR ELEVATE CYCLIC AMP

Methods and compositions are provided for treating a urinary tract infection (UTI). The methods involve administering to a subject in need thereof a cAMP elevator or agent that mimics cAMP, particular..

SYSTEMS AND METHODS FOR DETERMINING HEMOGLOBIN CONCENTRATION UTILIZING DIFFUSE REFLECTANCE AT ISOSBESTIC WAVELENGTHS

Systems and methods for determining hemoglobin concentration utilizing diffuse reflectance at isosbestic wavelengths are provided. In one embodiment, the method includes emitting light onto a tissue m..

INHIBITING GS-FDH TO MODULATE NO BIOACTIVITY

Patients needing NO donor therapy or inhibition of pathologically proliferating cells or increased NO bioactivity are treated with a therapeutically effective amount of an inhibitor of glutathione-dep..

ANTI-LIPID ANTIBODIES

The present invention relates, in general, to anti-lipid antibodies and, in particular, to methods of inhibiting HIV-I infection using anti-lipid (e.g. anti-phospholipid) antibodies.

A METHOD OF DETECTING ANTIBODIES AND ANTIBODY-HIV VIRION COMPLEXES

The present invention relates, in general, to HIV and, in particular to a method of detecting anti-HIV antibodies and antibody-HIV virion complexes.

Treatment For Diseases Relying On Discovery That Thioredoxin Mediates Nitric Oxide

Patients having a disease associated with high level of thioredoxin system activity or a requirement for nitric oxide, e.g. large cell lymphoma or restenosis, are treated with a thioredoxin reductase ..

REVERSIBLE PLATELET INHIBITION

The present invention relates, in general, to receptors and to platelet aggregation and, in particular, to a method of inhibiting platelet aggregation using an aptamer that binds to and inhibits the a..

THERAPEUTIC AGENTS FOR NEURODEGENERATIVE DISEASES

Methods of treating diseases involving protein aggregation are provided. Methods of identifying and selecting an autophagosome/lysosome fusion enhancer are also provided.

Early Detection of Pathogens in Blood

The present invention is a method of extracting infectious pathogens from a volume of blood including the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis re..

METHODS OF TREATING DISEASE-INDUCED ATAXIA AND NON-ATAXIC IMBALANCE

Methods for treatment of disease-induced ataxia and non-ataxic imbalance are disclosed. The methods involve treating a patient with a compound having nicotinic acetylcholine receptor activity.

METHOD OF TREATING CHRONIC MYELOGENOUS LEUKEMIA CELLS

Here, the inventors disclose the treatment of imatinib mesylate resistant chronic myelogenous leukemia cells with a cotreatment of vorinostat (SAHA, suberoylanilide hydroxamic acid) and dasatinib, a d..

DELTA-TOCOTRIENOL TREATMENT AND PREVENTION OF PANCREATIC CANCER

Methods are disclosed for treating neoplastic disorders, such as pancreatic cancer, using tocotrienols; namely, gamma-tocotrienol and delta tocotrienol. The antitumorogenic effects of these compounds ..

WITHACNISTIN COMPOUNDS FOR TREATMENT OF CANCER

The subject invention pertains to the treatment of tumors and cancerous tissues and the prevention of tumorigenesis and malignant transformation through the modulation of STAT3 intracellular signaling..

MATERIALS AND METHODS FOR TREATING ALLERGIC AND INFLAMMATORY CONDITIONS

The subject invention provides for the utilization of bone-marrow derived stem cells in the treatment of allergic and inflammatory diseases. In one embodiment, the invention provides for treatment of ..

Urodilatin Cancer Treatment

Urodilatin, a peptide formed in the kidney, has significant anticancer effects eliminating two-thirds of cancer cells within 24 hours.

Bone marrow-derived neuronal cells

Bone marrow stromal cells (BMSC) differentiate into neuron-like phenotypes in vitro and in vivo, engrafted into normal or denervated rat striatum. The BMSC administered into the ventricle did not rema..

PREVENTION, TREATMENT, AND DIAGNOSIS OF ALZHEIMER'S DISEASE THROUGH ELECTROMAGNETIC FIELD EXPOSURE

According to a first embodiment the invention includes a method of treating a neurological disorder, such as Alzheimer's Disease, in a subject in need thereof by positioning an electromagnetic field e..

COMPOSITIONS AND METHODS FOR ENHANCING NEUROPROTECTION VIA ADMINISTRATION OF STEM CELLS AND BLOOD BRAIN BARRIER PERMEABILIZERS

The present invention provides compositions and methods for enhancing the neuroprotective effect of umbilical cord blood cells. More particularly, the present invention provides methods of treating ne..

HUCBC TREATMENT OF AMYLOID ASSOCIATED DISEASE

Administration of human umbilical cord blood cells (HUCBC) or HUCBC-derived plasma is used to treat amyloid-based diseases, such as Alzheimer's disease, Huntington's disease, cerebral amyloid antigopa..

REELIN RESCUES COGNITIVE FUNCTION

Disclosed are methods of influencing, and enhancing, cognitive function by increasing, and/or preventing interference with, Reelin levels as well as Reelin signaling. Cognitive function is improved, i..

INHIBITORS OF AKT/PKB WITH ANTI-TUMOR ACTIVITY.

The subject invention concerns materials and methods for inhibiting the Akt/PKB pathway. In one embodiment, a compound of the invention inhibits kinase activity and/or phosphorylation levels of Akt pr..

CONTROL OF NK CELL FUNCTION AND SURVIVAL BY MODULATION OF SHIP ACTIVITY

Inhibition of dendritic cell function in solid organ grafts or allogeneic bone marrow transplants prior to or during engraftment by blocking SH2-containing inositol phosphatase (SHIP) expression or fu..

METHODS OF DIAGNOSING AND TREATING CANCER.

The invention relates to methods of determining an appropriate cancer therapy for a subject based on intratumoral expression levels of Ribonucleotide Reductase M1 (RRM1) and thymidylate synthase (TS) ..

NEURODEGENERATIVE DISEASE TREATMENT USING JAK/STAT INHIBITION

The invention relates to treatment of neurodegenerative diseases with JAK/STAT pathway inhibitors to eliminate extracellular cell signaling events leading to cell cycle abrogation and/or apoptosis. Pr..

Materials and methods for diagnosis, prevention and/or treatment of stress disorders and conditions associated with abeta peptide aggregation

The subject invention concerns materials and methods for treating and/or preventing diseases associated with accumulation of A[beta] peptide in neural tissue. The subject invention also concerns mater..

METHODS OF DETECTING AND TREATING COLON DISORDERS

The subject invention pertains to a method of detecting colon disorders including inflammatory bowel disease, such as Crohn's disease and ulcerative colitis, based on underexpression of Lipopolysaccha..

N,N'-DI-P-BROMOPHENYL GUANIDINE TREATMENT FOR STROKE AT DELAYED TIMEPOINTS

1,3 di-o-tolylguanidine (DTG) was examined as anti-stroke drug with a broad therapeutic window. DTG activates sigma 1 and 2 receptors. Administration of DTG at 24 hours post- stroke to rats reduces ne..

METHODS OF TREATING STROKE USING STEM CELL-LIKE MENSTRUAL BLOOD CELLS

A cell type that is a complete match of the transplant recipient appears as an optimal scenario to open treatment options to a large patient population with minimal complications. The use of autologou..

A METHOD AND COMPOSITION USING A DUAL SPECIFICITY PROTEIN TYROSINE PHOSPHATASE AS AN ANTIMALARIAL DRUG TARGET

Phosphotyrosine phosphatase (PTP) encoded by PF13_0027 is a desirable drug target for the human malaria parasite Plasmodium falciparum. This PTP is critical for intraerythrocytic parasite development ..

CT ATLAS OF THE BRISBANE 2000 SYSTEM OF LIVER ANATOMY FOR RADIATION ONCOLOGISTS

The method includes the steps of obtaining atlas data in an atlas coordinate set from a computer-readable atlas of hepatic anatomical information including three orders of division. The three orders o..

INDIVIDUALIZED CANCER TREATMENTS

The invention provides for compositions and methods for predicting an individual's responsitivity to cancer treatments and methods of treating cancer. In certain embodiments, the invention provides co..

COMBINATION OF INSULIN AND ASCORBATE TO ENHANCE WOUND HEALING

Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without asc..

METHOD OF RAPIDLY VISUALIZING ESSENTIAL NEURAL PATHWAYS

A method of optimizing pre-operative procedures in the field of neurosurgery. The method facilitates the identification of essential fiber tract pathways that must be avoided when planning and perform..

MATERIALS AND METHODS FOR PREVENTION AND TREATMENT OF RNA VIRAL DISEASES

The subject invention concerns a method of inhibiting an RNA virus infection within a patient by increasing the amount of 2-5 oligoadenylate synthetase (2-5 AS) activity within the patient. Preferably..

LEUKEMIA TREATMENT METHOD AND COMPOSITION

A method of inducing high anti-leukemia activity responsive to the combination of hydroxamic acid analogue histone deacetylase inhibitors and PKC412 against human acute leukemia characterized as expre..

Synergistic Modulation of Microglial Activation by Nicotine and THC

Treatment of microglial cells with nicotine and THC synergistically attenuate the microglial activation. Using microglial activation, the combination of THC and nicotine interact synergistically reduc..

MATERIALS AND METHODS FOR CAPTURE OF PATHOGENS AND REMOVAL OF AURINTRICARBOXYLIC ACID FROM A SAMPLE

The present invention concerns methods and materials for extracting infectious pathogens from a sample, such as blood, comprising the steps of creating a fibrin aggregate confining the pathogens and i..

METHODS OF TREATING COGNITIVE IMPAIRMENT

The subject invention concerns materials and methods for treating a person or animal having cognitive impairment. In one embodiment, the method comprises administering an effective amount of one or mo..

TISSUE CLASSIFICATION METHOD FOR DIAGNOSIS AND TREATMENT OF TUMORS

The present invention discloses an informational computation method for classifying objects Specifically, the invention is a system, method, and computer-readable media for classifying tumors using a ..

SHIP-DEFICIENCY TO INCREASE MEGAKARYOCYTE AND PLATELET PRODUCTION

A method of increasing megakaryocytes and platelet numbers in a patient comprising the step of inhibiting SHIP expression, including SHIP's enzymatic activity and signaling functions, whereby normal b..

ANTICANCER COMBINATION THERAPY INCLUDING TRICIRIBINE

This invention encompasses combination therapies including TCN, TCN-P, TCN-PM and/or related compounds and one or more additional anti-cancer agents, for example, taxanes a molecule that modulates the..

METHOD OF TREATING PERIPHERAL NERVE SENSORY LOSS USING COMPOUNDS HAVING NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVITY

Methods for treatment of peripheral nerve sensory loss are disclosed. The methods involve treating a patient with a compound having nicotinic acetylcholine receptor activity.

STERILE INFLATABLE DRAPE

A sterile inflatable drape includes a base having a size and shape adapted to cover a surgical site. A peripheral border surrounds the base. The base and the peripheral border have a first side covere..

REATMENT OF SUICIDAL IDEATION OR BEHAVIOR USING INHIBITORS OF NICOTINIC ACETYLCHOLINE RECEPTORS

The invention concerns methods of treating suicidal ideation or behavior in a subject in need thereof, comprising decreasing endogenous nicotinic acetylcholine receptor (nAChR) activity in the subject..

Cancer imaging and treatment

A compound, or a pharmaceutically acceptable salt or ester thereof, comprises a ligand for the chemokine receptor CXCR4 and a detectable label, the ligand having a binding affinity for the CXCR4 recep..

TROCAR TUBE, TROCAR, OBTURATOR, OR RECTOSCOPE FOR TRANSLUMINAL ENDOSCOPIC SURGERY VIA NATURAL BODY CAVITIES

The present invention relates to a trocar tube, trocar, obturator, rectoscope for transluminal endoscopic surgery via natural body cavities. A trocar tube (2) according to the invention is provided, h..

RADIOLABELED MONOMERIC AND MULTIMERIC CYCLIC OLIGOPEPTIDES BINDING TO THE CXCR4 RECEPTOR FOR CANCER IMAGING AND TREATMENT

A compound, or a pharmaceutically acceptable salt or ester thereof, comprises the structure: [(P1-S1j)p - L - (S2q-P2)r]t wherein: P1 and P2, which may be the same or different, are cyclic oligopeptid..

Fibroblast growth factor (fgf23) and methods for use

The invention relates to nucleic acids encoding a fibroblast growth factor-23 (FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invent..

MINIMIZED SMALL PEPTIDES WITH HIGH AFFINITY FOR FACTOR VIII AND FACTOR VIII-LIKE PROTEINS

The present invention relates to the composition of small molecules and their use in the field of protein isolation, purification, stabilizing and/or enhancing its activity. In particular, the present..

TROCAR TUBE, TROCAR, OBTURATOR, OR RECTOSCOPE FOR TRANSLUMINAL ENDOSCOPIC SURGERY VIA NATURAL BODY CAVITIES

The present invention relates to a trocar, trocar, obturator, Rektroskop for the transluminal endoscopic surgery via natural orifices. A trocar according to the invention is provided with a distal por..

MULTIPLE N-METHYLATED CYCLIC HEXAPEPTIDES FOR TREATMENT OF NEUROGENIC INFLAMMATION

The present invention relates to cyclic hexapeptides containing two or more N-alkyiations in their backbone. The described cyclopeptides are active as anti-inflammatory agents and/or analgesics and ma..

USE OF AN OZONE/OXYGEN MIXTURE AS PRIMARY ANTICANCER THERAPY THROUGH INTRAPERITONEAL INSUFFLATION

Squamous cell carcinomas of the ENT area (HNSCC) are a group of metastatic tumors with a high mortality rate in humans and animals. Since then discovered that the biomolecule ozone inhibits the growth..

METHODS FOR THE TREATMENT OF VIRAL CONDITIONS

The invention is directed to a method of stimulating PRF in a viral cell by administering an aminoglycoside antibiotic to said cell. In another embodiment, the invention is directed to a method of inh..

Methods and Compositions for Facilitating Tissue Repair and Diagnosing, Preventing, and Treating Fibrosis

Compositions and methods for facilitating tissue repair by enhancing the actions of BIGH3 or at least one of its downstream effector molecules in injured tissue, and for the diagnosis, prophylactic an..

AMINOFLAVONE (NSC 686288) AND COMBINATIONS THEREOF FOR TREATING BREAST CANCER

Disclosed are methods of treating breast cancer by administering to a mammal aminoflavone, and optionally one or more additional anti-cancer agents. According to example embodiments, the methods inclu..

METHODS OF TREATING A MICROBIAL INFECTION BY MODULATING RNASE-L EXPRESSION AND/OR ACTIVITY

The invention relates to methods and compositions for treating a microbial infection. In the present invention, RNase-L activity has been shown to play an integral role in innate immunity and for defe..

SMALL MOLECULE INHIBITORS OF LCK SH2 DOMAIN BINDING

The present invention provides, materials and methods for modulating an immune response. The materials and methods may be used to treat diseases associated with an aberrant immune response. In some em..

INHIBITORS OF NCCA-ATP CHANNELS FOR THERAPY

Methods and compositions are provided that are utilized for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN), particularly following spinal cord inj..

Potent Inhibitory Effect of Zinc in Combination with Sulforaphane on Cancer Cell Growth

This invention relates to compositions comprising zinc and sulforaphane which can be used in the treatment or prevention of cancer. The invention also relates to methods of treating or preventing canc..

METHODS FOR REGULATING URINARY POTASSIUM

The internalization sequence at the C-terminal end of the ROMK protein has been identified and sequenced. It has been discovered determined that endocytosis is triggered by binding of the ROMK interna..

COMPOSITIONS AND METHODS OF INDUCING ENDOPLASMIC RETICULUM STRESS REPONSE

The present invention provides methods of inducing cell cycle arrest and/or cell growth inhibition, with the methods comprising administering to the cells an effective dose of the compounds of the pre..

DOCOSAHEXAENOIC ACID FOR THE TREATMENT OF HEART FAILURE

There is currently no completely effective treatment for heart failure. Considering the need for, and current void in the medical field for, a treatment for heart failure, the invention is drawn to tr..

METHODS OF TREATING A DIABETIC EMBRYOPATHY

Maternal diabetes can lead to a developmental malformation of an embryo. A developmental malformation caused by maternal diabetes is commonly referred to as a diabetic embryopathy. There is currently ..

Methods for Treating Central Pain Syndrome and Other Pain Related Pathologies

Central pain syndrome (CPS) is a debilitating condition that affects a large number of patients with a primary lesion or dysfunction in the central nervous system. Despite its discovery over a century..

EGFR AND PAR2 REGULATION OF INTESTINAL PERMEABILITY

The present invention provides a method of treating an autoimmune disease, comprising the steps of increasing transepithelial electrical resistance leading to decreased cell permeability. Further prov..

DERIVATIVES OF APF AND METHODS OF USE

Derivatives of a novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagno..

IN VIVO BIOFILM INFECTION DIAGNOSIS AND TREATMENT

The present invention relates to a method for in vivo detection of a biof?lm infection residing in a mammal, the method comprising (i) administering to the mammal a diagnostic-effective amount of a bi..

METHOD OF TREATING ORGANOPHOSPHOROUS POISONING

The present invention is directed to various methods for treating organophosphorus poisoning in an animal that is at risk of exposure to an organophosphorus compound or preventing organophosphorus poi..

DERIVATIVES OF APF AND METHODS OF USE

Derivatives of bladder epithelial antiproliferative factor and methods of using them are disclosed. In specific embodiments, the glycopeptide compositions are useful for the treatment and/or preventio..

SUR1 INHIBITORS FOR THERAPY

Methods and compositions are provided that are utilized for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN). In particular, the methods and composi..

MONOCLONAL ANTIBODIES FOR TREATMENT OF CANCER

The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer,..

MONOCLONAL ANTIBODIES AGAINST CLAUDIN-18 FOR TREATMENT OF CANCER

The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDl 8, including tumor-related diseases such as gastric cance..

IDENTIFICATION OF TUMOR-ASSOCIATED MARKERS FOR DIAGNOSIS AND THERAPY

The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products ..

USE OF RNA FOR REPROGRAMMING SOMATIC CELLS

The present invention provides methods for de-differentiating somatic cells into stem-like cells without generating embryos or fetuses. More specifically,-the present invention provides methods for ef..

METHODS INVOLVING MS4A12 AND AGENTS TARGETING MS4A12 FOR THERAPY, DIAGNOSIS AND TESTING

The invention relates to methods involving MS4A12 and agents targeting MS4A12 which are useful for therapy, diagnosis and testing of disease states, in particular cancer diseases. In particular, the i..

USE OF FLT3 LIGAND FOR STRENGTHENING IMMUNE RESPONSES IN RNA IMMUNIZATION

The invention relates to supplying vaccine RNA to cells. The invention relates in particular to a common use of vaccine RNA and Flt3 ligand for inducing, creating or enhancing an immune response when ..

METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF CANCER

The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which represent t..

IDENTIFICATION OF TUMOR-ASSOCIATED MARKERS FOR DIAGNOSIS AND THERAPY

MONOCLONAL ANTIBODIES FOR TREATMENT OF CANCER

VACCINE COMPOSITION COMPRISING 5'-CAP MODIFIED RNA

The present invention relates to modification of RNA with 5 '-cap analogs in order to improve the stability and increase the expression of said RNA, in particular in immature antigen presenting cells...

ANTIBODIES SPECIFIC FOR CLAUDIN 6 (CLDN6)

The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ov..

DELIVERY OF TRANSTHYRETIN ACROSS THE BLOOD-BRAIN BARRIER AS A TREATMENT FOR ALZHEIMER'S DISEASE

The invention provides a composition comprising transthyretin and an ICAM-1 targeting agent, wherein the transthyretin and ICAM-1 targeting agent are coupled together, as well as methods of preparing ..

ADVANCED FUNCTIONAL BIOCOMPATIBLE FOAM USED AS A HEMOSTATIC AGENT FOR COMPRESSIBLE AND NON-COMPRESSIBLE ACUTE WOUNDS

A sprayable polymeric foam hemostat for both compressible and non-compressible (intracavitary) acute wounds is disclosed. The foam comprises hydrophobically-modified polymers, such as hm-chitosan, or ..

Identification of tumor-associated antigens for diagnosis and therapy

METHODS AND COMPOSITIONS FOR INHIBITING ANGIOGENESIS

The present invention relates to methods and compositions for modulating angiogenesis. In particular, the present invention relates to Pigment Epithelial-derived Factor (PEDF) fragments for use in mod..

Compositions And Methods For Treatment, Research And Therapeutic Applications For Malaria

The present invention provides anti-Plasmodium immunogenic compositions comprising EVP1 (PFD0495c) or an antigenic portion thereof, as well as methods of immunizing against malaria employing these com..

METHOD OF REGULATING THE HEAT SHOCK RESPONSE

The present invention is directed to method of modulating a heat shock response in a first cell of a multicellular organism comprising stimulating or inhibiting an HSR signaling activity of a second c..

COMPOSITIONS AND METHODS FOR TREATING ATRIAL FIBRILLATION

The present invention provides compositions and methods for treating heart conditions. In particular, the present invention provides compositions and methods that block G protein coupled receptor medi..

Compositions and Methods For Treating Bone Formation Disorders

The present invention relates to compositions and methods for the detecting, treating, and empirically investigating disorders associated with bone formation (e.g., osteoporosis). In particular, the p..

DELIVERY SCAFFOLDS AND RELATED METHODS OF USE

The present invention relates to delivery systems. In particular, the present invention provides microporous scaffolds having thereon agents (e.g., extracellular matrix proteins, exendin-4) and biolog..

METHODS AND COMPOSITIONS FOR MODULATING CALCIUM CHANNELS

The present invention relates to methods and compositions for modulating calcium channels. In particular, the present invention provides methods and compositions for modulating (e.g., disrupting) Cav1..

Use of SCF and G-CSF in the Treatment of Cerebral Ischemia and Neurological Disorders

The present invention relates to the use of stem cell factor (SCF) polypeptide, alone and in combination with granulocyte colony stimulating factor (G-CSF) polypeptide, in the prevention or treatment ..

CARDIAC PACING LEAD AND DELIVERY SHEATH

The present invention provides compositions and methods related to epicardial pacing systems. In particular, the present invention provides a novel delivery sheath and cardiac pacing lead to be deploy..

METHOD FOR REMOVAL OR INACTIVATION OF HEPARIN

The present invention relates to the use of immobilized RAGE or portions thereof for removal of heparin and low molecular weight heparin from a fluid sample or from a patient in need of neutralization..

Pathogenecity Islands of Pseudomonas Aeruginosa

Disclosed are Pseudomonas aeruginosa Genomic Island nucleic acid sequences referred to as PAGI-5, PAGI-6, PAGI-7, PAGI-8, PAGI-9, PAGI-10, and PAGI-11. These nucleic acid sequences may be useful in me..

CARDIOPROTECTIVE ROLE OF HEPATIC CELLS AND HEPATOCYTE SECRETORY FACTORS IN MYOCARDIAL ISCHEMIA

The present invention provides methods, compositions, and systems for treating a subject at risk for, with, or suspected of having, myocardial ischemia using hepatocyte secretory factors (e.g., AGP2, ..

SEALANTS FOR MEMBRANE REPAIR

The present invention provides a method for preventing or repairing damage to a fetal membrane. In one embodiment, the method comprises contacting a fetal membrane with a composition comprising a four..

POLYVALENT POLYNUCLEOTIDE NANOPARTICLE CONJUGATES AS DELIVERY VEHICLES FOR A CHEMOTHERAPEUTIC AGENT

The present invention is directed to compositions and methods of delivering a chemotherapeutic agent via a polynueleotide-functionalized nanoparticle (PN-NP).

Methylation Profile of Neuroinflammatory Demyelinating Diseases

The present invention relates to compositions and methods for diagnosing neuroinflammatory demyelinating diseases, including but not limited to, multiple sclerosis. In particular, the present inventio..

COMPOSITIONS AND METHODS FOR URINARY BLADDER REGENERATION

The present invention provides compositions and methods for the regeneration of tissue. In particular, the present invention provides mesenchymal stem cells (MSCs) and endothelial progenitor cells (EP..

LIVE-ATTENUATED COMPOSITIONS FOR BACTERIAL INFECTIONS

The present invention relates to compositions and methods for disease treatment and prevention through administration of a live attenuated composition. In particular, the present invention provides co..

COMPOSITIONS AND METHODS FOR TREATING CONDITIONS ASSOCIATED WITH NEURONAL DYSFUNCTION

The present invention relates to compositions and methods for the treating and empirically investigating conditions associated with neuronal dysfunction (e.g., chronic pain, epileptic neuronal activit..

Surface Independent, Surface-Modifying, Multifunctional Coatings and Applications Thereof

The invention provides surface treatments that reduce or eliminate marine biofouling of various surfaces. A surface that is to be subjected to a marine environment can be treated with a mPEG-DOPA. The..

METHOD FOR REDUCING SCARRING DURING WOUND HEALING USING ANTISENSE COMPOUNDS DIRECTED TO CTGF

This invention provides a method for reducing hypertropic scarring resulting from dermal wound healing in a subject in need which comprises administering to the subject an antisense oligonucleotide wh..

METHODS FOR SCAR PREVENTION

Provided herein are compositions and methods for preventing or reducing scar formation (e.g., hypertrophic scars). For example, provided herein are methods of administrating HMG-CoA-inhibiting agents ..

COMPOSITIONS AND METHODS FOR TREATING LYMPHOMA

Provided are compositions comprising PX-478, or metabolites, analogs or derivatives thereof for treatment of lymphoma.

USE OF ECDI-FIXED CELL TOLERANCE AS A METHOD FOR PREVENTING ALLOGRAFT REJECTION

The present invention provides methods, systems, and compositions for inducing donor-specific tolerance. In particular, the present invention provides methods of administering ECDI-treated cells befor..

Methods, Compositions and Articles of Manufacture for Contributing to the Treatment of Cancers

Methods, compositions and articles of manufacture for contributing to the treatment of cancers, including solid tumors, are disclosed. The methods, compositions and articles of manufacture can utilize..

ANTICOAGULANT ANTAGONIST AND HEMOPHILIA PROCOAGULANT

A method for treating a coagulation deficient patient comprises administering an amount of polyP to the patient sufficient to reduce the PT Test value or Dilute PT Test value of the plasma of the pati..

MINIMALLY-INVASIVE MEASUREMENT OF ESOPHAGEAL INFLAMMATION

The methods and apparatus of the present invention allow the evaluation of inflammation of the esophagus. Measurements may be utilized, for example, to diagnose a disease of the esophagus, to monitor ..

FIBRIN SEALANT

A fibrin sealant, comprises (a) thrombin, (b) fibrinogen, (c) polyP, and (d) calcium. The thrombin and the fibrinogen are separated prior to application.

ENCAPSULATED MATERIALS AND METHODS FOR ENCAPSULATING MATERIALS

A system that incorporates teachings of the present disclosure may include, for example, an apparatus having an outer nozzle operable to discharge an outer stream of a shell solution, and an inner noz..

COMPOSITIONS AND METHODS FOR TREATING PULMONARY HYPERTENSION

Provided herein are methods and materials for treating pulmonary hypertension (PH) in a subject. Also provided herein is a method of diagnosing whether a has PH by detecting a PH marker. A PKG pulmona..

COMPOSITIONS COMPRISING DECITABINE AND TETRAHYDROURIDINE AND USES THEREOF

Compositions comprising decitabine and tetrahydrouridine for the treatment of blood disorders and hematological and solid malignancies are described.

Functional Role for Cannabinoids in Autonomic Stability During Sleep

The present invention relates generally to pharmacological methods for the prevention or amelioration of sleep-related breathing disorders via administration of cannabimimetic agents and combinations ..

METHOD OF TREATING NEUROLOGICAL DISEASES

A method of treating neurological diseases, like Alzheimer's Disease by administering a compound that activates protein kinase C and inhibits histone deacetylases to an individual suffering from the n..

PHOSPHOLIPID MICELLAR AND LIPOSOMAL COMPOSITIONS AND USES THEREOF

The invention generally relates to compositions and methods for the reduction or neutralization of toxins associated with a bacterial, mycobacterial, fungal, viral, or protozoal agent. More particular..

Modulation of Platelet Aggregation

Methods and compositions for inhibition of platelet cell aggregation are described. In particular, compositions comprising cell permeant RGT peptides, such as RGT bound to a lipid moiety are provided...

METHODS AND COMPOSITIONS FOR THE INHIBITION OF THROMBUS FORMATION

The present invention is directed to compositions comprising inhibitors of GPIb-IX-VWF binding and methods of treating or preventing thrombosis associated with sepsis or endotoxemia in a mammal.

ANTI-BACTERIAL COMPOSITIONS AND METHODS INCLUDING TARGETING VIRULENCE FACTORS OF STAPHYLOCOCCUS AUREUS

This disclosure relates to compositions and methods including for the inhibition, prevention, and/or treatment of microbial infections, including infections from such pathogens as Staphylococcus aureu..

Method and Composition for Treating Alzheimer's Disease and Dementias of Vascular Origin

A composition and method of treating Alzheimer's disease or a dementia of vascular origin are disclosed. The composition and method utilize an endothelin antagonist as the active agent to treat Alzhei..

COMPOSITIONS AND METHODS FOR TREATING A DISEASE MEDIATED BY SOLUBLE OLIGOMERIC AMYLOID BETA

The present invention relates to methods for restoring fast axonal transport in a cell affected by oligomeric amyloid beta and for treating an oligomeric amyloid beta- mediated disease such as Alzheim..

COMPOSITIONS AND METHODS FOR THE TREATMENT OF MYOCARDIAL DYSFUNCTION ASSOCIATED WITH SIRS OR SEPSIS

Provided are compositions and methods for the treatment of myocardial dysfunction associated with SIRS or sepsis, which methods comprise the administration to a patient in need thereof of a compositio..

METHOD FOR DETECTING THE EXISTENCE OF RENAL CALCULI AND/OR INFLAMMATION OF THE EXCRETORY URINARY TRACTS

The invention relates to methods for detecting diseases of the excretory urinary tracts. The aim of the invention is to provide a method for detecting the existence of diseases of the excretory urinar..

METHOD OF DETERMINING SENSITIVITY OF HUMAN OR NON-HUMAN ANIMAL CELLS TO AN IAP ANTAGONIST

cFLIP serves as a biomarker for efficacy of treatment with IAP antagonists, including Smac peptidomimetics.

X-RAY MARKER FOR VISUALLY COMPARING AND FOR CONTROLLING THE IMAGE PROCESSING IN DIGITAL X-RAY RECORDINGS, IN PARTICULAR FOR A THORAX X-RAY RECORDING FOR A PATIENT LYING DOWN

The invention relates to an X-ray marker (1) that is also to be X-rayed in an X-ray recording of an organ of a patient (3) to be examined. The X-ray marker (1) has such a geometric X-ray weakening str..

DEVICE FOR DETERMINING VERTEBRAL DISTANCES OF THE SPINAL COLUMN OF A PATIENT

The invention relates to devices for determining vertebral distances of the spinal column of a patient. The devices are characterized in particular in that vertebral distances of the patient while wal..

MODULATION OF MLCK-L EXPRESSION AND USES THEREOF

In various aspects and embodiments the invention provides methods and reagents for controlling gene expression, and for treating disorders and diseases. Embodiments provide methods and reagents specif..

METHODS OF TREATING DIASTOLIC DYSFUNCTION AND RELATED CONDITIONS

The invention provides a method of treating diastolic dysfunction, e.g., diastolic dysfunction with preserved ejection fraction, in a subject. The method comprises administering to the subject in an a..

COMPOSITIONS AND METHODS FOR THE TREATMENT OF KRABBE AND OTHER NEURODEGENERATIVE DISEASES

Provided are compositions and methods for the treatment of Krabbe and other neurodegenerative diseases, including storage diseases such as GMl gangliosidosis, Niemann-Pick disease, Tay-Sachs disease, ..

Method and Composition for Potentiating an Opiate Analgesic

Composition and methods of treating pain and reducing or reversing tolerance to opiate analgesics are disclosed. The composition and method utilize an opiate analgesic and an endothelin antagonist as ..

HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME

Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a..

ANTIMICROBIAL THERAPY FOR BACTERIAL INFECTIONS

The disclosure provides compounds and methods to treat bacterial pathogenesis, and demonstrates that the S. aureus pigment is a virulence factor and potential novel target for antimicrobial therapy.

COMPOSITIONS AND METHODS FOR INHIBITING ENTRY OF A HEPATIC VIRUS

The present invention embraces Niemann-Pick C1-like 1 protein antagonists and agents that inhibit hepatic virus infection for use in the prevention and treatment of a hepatic virus infection.

Materials and Methods for Making Improved Micelle Compositions

Provided are methods of treatment of many different diseases and disorders using micelle and sterically stabilized crystalline compounds of the invention.

Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells

Solutions and suspensions comprising polymerized hemoglobin derived from human blood are disclosed. The solutions and suspensions may comprise cell culture medium, an enzyme (such as a protease), and/..

SELF-ASSEMBLED TOROIDAL-SPIRAL PARTICLES AND MANUFACTURE AND USES THEREOF

Toroidal-spiral shaped particles, their method of manufacture, and uses thereof are disclosed. The toroidal-spiral particles can contain at least one active agent, such as a drug, and provide a contro..

Anti-inflammatory and anti-HIV compositions and methods of use

The metabolic fingerprint and anti-inflammatory activity and anti-HIV activity of H. gentianoides is disclosed. High performance liquid chromatography (HPLC) analysis shows that H. gentianoides contai..

METHODS AND COMPOSITIONS FOR TREATING BRAIN DISEASES

The present disclosure provides targeting peptides and vectors containing a sequence that encodes targeting peptides that deliver agents to the brain.

BIOACTIVE SUTURES FOR THE TREATMENT OF CANCER

The present invention relates to compositions and method for the treatment of cancer using a suture or dressing providing a plurality of tumor cell antigens and/or an immunostimulatory agent to a subj..

RCA LOCUS ANALYSIS TO ASSESS SUSCEPTIBILITY TO AMD AND MPGNII

The invention relates to gene polymorphisms and genetic profiles associated with an elevated or a reduced risk of alternative complement cascade deregulation disease such as AMD and/or MPGNII. The inv..

PRENYLATED BISPHOSPHONATES AS ANTI-TUBERCULOSIS AGENTS

The invention provides methods to treat a mycobacterium infection and methods to inhibit mycobacterial polyprenyl pyrophosphate synthesis with a compound of formula I. The invention also provides nove..

Diagnosis and Treatment of Age-Related Macular Degeneration

The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of AMD..

METHOD AND COMPOSITIONS FOR TREATING AND PREVENTING SEIZURES BY MODULATING ACID-SENSING ION CHANNEL ACTIVITY

This invention provides novel methods and compositions for treating and preventing seizures by administration of ASIC1a receptor activating compounds. A novel method of assaying ASIC1a receptor activa..

REPEATED ADMINISTRATION OF LENTIVIRAL VECTORS TO RESPIRATORY CELLS

The invention provides methods for administering lentiviral vectors to the respiratory system of a patient to treat a disease.

ANKLE PROSTHESIS METHODS

Methods of implanting an ankle prosthesis in a subject having an ankle joint in need of replacement.

TREATMENT OF HEPATITIS C VIRUS INFECTIONS

This present invention provides for a new class of HCV NS3/4A protease inhibitors as additional therapeutics for hepatitis C virus. The proposed compounds, bilverdin, bilirubin, and derivatives thereo..

Use of unmethylated CpG oligonucleotides for the treatment of allergy

An immuostimulatory nucleic acid containing an unmethylated CpG dinucleotide for use in a method of treating or preventing an allergy in a subject, wherein an effective dose of the immunostimulatory n..

Vaccine, therapeutic composition and methods for treating or inhibiting francisella tularenis

The present invention is directed to compounds and methods for treating a mammal exposed to Francisella tularensis.

Methods of Treating Pulmonary Diseases and Disorders by Modulating Calcium/Calmodulin Dependent Protein Kinase II Activity

Disclosed are methods of treating or preventing a pulmonary disease or disorder in a subject, the methods comprising administering an effective amount of an compound that inhibits Calmodulin Kinase II..

CONTROLLED-RELEASE IMMUNOGENIC FORMULATIONS TO MODULATE IMMUNE RESPONSE

Single-dose controlled-release immunogenic formulations, such as vaccines, based on bioerodible polyanhydride copolymer or homopolymer microparticles for the control of immune response mechanisms are ..

Canine influenza virus and related compositions and methods of use

Un virus de la influenza canina aislado del subtipo H3N8 depositado con la American Type Culture Collection como Depósito de Patente No. PTA-7694.

METHOD FOR PRECISELY DETERMINING THE FLUORESCENCE IN A LAYER SYSTEM, SUCH AS THE EYE

The invention relates to a method for precisely determining the fluorescence in a layer system, such as the eye. The object of the invention is to provide a method that is as simple and requires as li..

Hybrid method for 3D shape measurement

A method for three-dimensional shape measurement provides for generating sinusoidal fringe patterns by defocusing binary patterns. A method for three-dimensional shape measurement may include (a) proj..

TREATING CANCER WITH DESTHIAZOLYL RITONAVIR

Treatment of cancer includes administering a compound of formula I, for example desthiazolyl ritonavir, to a subject. In particular, treatment of breast cancer is described.

CATALYTIC TOPOISOMERASE II INHIBITORS

The invention provides methods and compositions useful for treating cancer, for selectively inhibiting topoisomerase II, and for inducing apoptosis.

ISCHEMIA/REPERFUSION PROTECTION COMPOSITIONS AND METHODS OF USING.

The invention provides for ischemia/reperfusion protection compositions having one or more ketone bodies and melatonin. The invention also provides for methods of using such compositions to reduce or ..

DNA CYTOSINE DEAMINASE INHIBITORS

Cytosine deaminase inhibitors and methods for identifying inhibitors of the anti-retroviral activity of APOBEC3G are described.

METHODS OF TREATING HIV PATIENTS WITH ANTI-FIBROTICS

The invention relates to methods of treating patients infected with human immunodeficiency virus (HIV) with a therapeutic that has anti-fibrotic effects, for example, pirfenidone and analogs thereof.

DECELLULARIZATION AND RECELLULARIZATION OF ORGANS AND TISSUES

The invention provides for methods and materials to decellularize an organ or portion thereof and to recellularize such a decellularized organ or portion thereof to thereby generate an organ or portio..

METHODS AND MATERIALS FOR ISOLATING ISOGENIC ISLET CELLS

Compositions and methods for isolating and purifying islet cells are described. Islets obtained using such compositions and methods can be transplanted into diabetic patients.

METHODS AND SYSTEMS FOR TREATING AND PREVENTING CARDIAC INJURY IN DYSTROPHIC SUBJECTS

The present invention provides methods for treating and preventing cardiac deficiencies and injuries (e.g., cardiac injury and ventricular dilation) in dystrophic subjects using poloxamer containing c..

BIORESORBABLE EMBOLIZATION MICROSPHERES

The present disclosure is generally directed to an embolic material which is in the form of a microsphere or a plurality of microspheres. The embolic material generally comprises carboxymethyl chitosa..

RECEPTOR-TARGETING REAGENTS

The present disclosure features, inter alia, receptor-targeting reagents (e.g., immunotoxic receptor-targeting reagents), which are useful in, e.g., methods of binding a receptor-targeting reagent to ..

METHOD FOR IDENTIFYING INDIVIDUAL VIRUSES IN A SAMPLE

The problem of the invention consisted in identifying individual viruses in an arbitrary sample quickly, unambiguously and reliably, and with the least possible preparation-related and technology-rela..

METHOD FOR IDENTIFYING INDIVIDUAL VIRUSES IN A SAMPLE

COMPOSITIONS AND METHODS FOR REPAIR OF TISSUES

Biomaterials providing sustained release of growth factor for repair of tissues such as bone and cartilage are disclosed. The biomaterials comprise a proteoglycan derived from domain I of perlecan and..

Pan-Antagonists For The Androgen Receptor And Androgen Receptor Mutants Associated With Anti-Androgen Withdrawal

Disclosed herein are novel antagonists of the androgen receptor and androgen receptor mutations associated with clinical failure of currently prescribed anti-androgens and use of said antagonists in t..

METHODS OF ADMINISTERING PORCINE B-DOMAINLESS FVIII

The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against blee..

MODIFIED FACTOR VIII

Methods of treating patients with Factor VIII deficiency by administration of modified porcine factor VIII are disclosed. The particular modified porcine factor VIII is one in which most of the B doma..

COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS.

PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using th..

NUCLEOSIDE DERIVATIVES FOR TREATMENT OF CALICIVIRIDAE INFECTIONS, INCLUDING NOROVIRUS INFECTIONS

A method and composition for treating a host infected with a Caliciviridae virus, such as a Norovirus, comprising administering an effective treatment amount of a described modified nucleoside or a ph..

VASCULAR ACCESS TO EXTRA-VASCULAR SPACE

Provided are methods for accessing tissue in the vicinity of a blood vessel. Also provided are devices for use in a lumen of a patient's organ and methods for shunting interior volumes of organs.

SYSTEMS AND METHODS FOR PREVENTING MISTRANSFUSION

In some embodiments, a system and a method for preventing mistransfusion of a patient pertain to obtaining a sample of the patient's blood, obtaining a sample of blood that is about to be infused into..

Methods of Determining Renal Function using Technetium-99m Tricarbonyl-nitrilotriacetic acid

This disclosure relates to the methods of imaging the kidneys and measuring renal function using the renal tracer 99mTc(CO)3(NTA) (technetium-99m tricarbonyl-nitrilotriacetic acid). The disclosure enc..

COMPOSITIONS AND METHODS FOR TREATMENT OR PREVENTION OF POST-OPERATIVE ORGAN OR TISSUE INFLAMMATION

Compositions, methods and kits for treatment or prevention of post operative organ or tissue inflammation are provided. The compositions contain an effective amount for local delivery, of an anti-infl..

METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS

PD-I antagonists are disclosed that can be used to reduce the expression or activity of PD-I in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using th..

Treatment of EBV and KHSV Infection and Associated Abnormal Cellular Proliferation

A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an effe..

TREATING VARIOUS DISORDERS WITH 7,8-DIHYDROXYFLAVONE AND DERIVATIVES THEREOF

Novel compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of 7,8-dihydroxyflavon..

METHODS FOR THE TREATMENT OF GRAFT-VERSUS-HOST DISEASE

Methods are disclosed for treating or preventing graft versus host disease in a subject. The methods include selecting a subject in need of treatment for graft versus host disease; and administering t..

METHODS FOR THE TREATMENT OF A TRAUMATIC CENTRAL NERVOUS SYSTEM INJURY

Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-l..

METHODS FOR PREVENTING OXIDATIVE STRESS INJURY OF A TISSUE BY A FOLATE-TEMPOL CONJUGATE

The present disclosure is generally related to methods of preventing oxidative stress injury induced by renal ischemia-reperfusion by a Folate-TEMPOL conjugate.

XENOTROPIC MULV-RELATED VIRUS (XMRV) COMPOSITIONS AND METHODS OF USE

The invention relates to compositions and methods for analyzing and treating a disease, disorder, or condition associated with an XMRV infection.

SMALL MOLECULE LIGAND-DRUG CONJUGATES FOR TARGETED CANCER THERAPY

The present invention describes small molecule ligand-drug conjugates and methods of using the small molecule ligand-drug conjugates for targeted treatment of cancer in a patient in need thereof. Furt..

MICROPARTICLES FOR DELIVERY TO CELLS AND/OR TISSUES

Delivery of bioactive molecules (BAMs) to organelles, cells, tissues, or animals with high efficiency is desirable. Novel compositions for highly efficient delivery of bioactive molecules by biolistic..

MUCOSAL IMMUNIZATION

Methods and compositions for eliciting an immune response to an antigen are disclosed. In certain aspects, these methods concern eliciting an immune response in a subject by administering to the mucos..

BISPECIFIC NANOBODIES AS A THERAPEUTIC FOR ALZHEIMER'S DISEASE

The present invention provides for the treatment of Alzheimer's disease. More specifically, a recombinant bispecific antibody fragment that simultaneously blocks beta-secretase activity while also pro..

RECOMBINANT BACTERIUM CAPABLE OF ELICITING AN IMMUNE RESPONSE AGAINST ENTERIC PATHOGENS

The present invention relates to a recombinant bacterium that is capable of eliciting an immune response against at least two enteric pathogens, without substantially inducing an immune response speci..

METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING PRURITIS

The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.

COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING RADIATION INJURY

The invention provides compositions and methods featuring Nrf2 activators for treating or preventing radiation-associated tissue damage.

TREATMENT OF CHRONIC INFLAMMATORY RESPIRATORY DISORDERS

This invention relates, e.g., to a method for treating a subject having a chronic inflammatory respiratory disorder, comprising administering to the subject an effective amount of an inhibitor of the ..

COMPOSITIONS AND METHODS OF TREATING ENDOTHELIAL DISORDERS

Compositions and methods of treating endothelial disorders, including: asthma, erectile dysfunction, pulmonary hypertension, cardiovascular disorders, and other disorders, using a synergistic combinat..

Treating cancer by increasing intracellular malonyl CoA levels

A method of killing cancer cells by acute elevation of cellular malonyl Coenzyme A (Malonyl CoA) which leads to apoptosis. Elevation of malonyl CoA may be induced by inhibition of fatty acid synthase ..

COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING HEART TISSUE DEGENERATION AND USES THEREOF

The present invention provides compositions useful for cardiac therapy comprising a cyclin-associated agent. The present invention also provides kits for use in delivering a cyclin-associated agent to..

SUSTAINED RELEASE FORMULATION OF MELATONIN

The present invention relates to low-dose formulations of melatonin, and methods of use thereof, which provide a sustained release of melatonin so as to rapidly increase plasma levels of melatonin, ma..

INFLAMMATION-REGULATING COMPOSITIONS AND METHODS

The various embodiments provide a composition that provides local control over inflammation. The composition localizes the activities of the cytokine-neutralizing antibodies to the site of inflammatio..

ANTIBODIES AND CONJUGATES FOR MODULATORS OF ANGIOGENESIS

We provide methods and compositions for the treatment of dysregulation of blood vessel growth by regulation of neovascularization. Embodiments accomplish this by restricting the diffusion and transpor..

METHOD OF ASSESSING A BODY PART

A method of assessing a body part includes obtaining two or more types of data through a combination of two or more of the following four imaging modalities: (1) obtaining surface topography data of t..

SYNTHETIC OSTEOCHONDRAL COMPOSITE AND METHOD OF FABRICATION THEREOF

An osteochondral composite (10) including a hydrogel (24) with implanted biological cells (26) joined to a porous supportive base (12) at a mechanically-interlocked interface is disclosed. A method of..

TREATMENT OF TYPE 1 DIABETES BEFORE AND AFTER EXPRESSION OF PREDISPOSITION MARKERS

The present invention relates generally to the use of compounds, compositions, combinations, kits, and methods for the effective endocytic presentation of immunosuppressive factors for the down regula..

ROTATOR CUFF BONE-TENDON ALLOGRAFT

The invention provides a biomaterial and a method of selecting a biomaterial for a rotator cuff repair procedure. The biomaterial includes a bone-tendon allograft and the use of the biomaterial in rot..

CALCIUM PHOSPHATE BODIES AND A PROCESS FOR MAKING CALCIUM PHOSPHATE BODIES

Among the various aspects of the present invention is a process for making calcium phosphate bodies comprising amorphous calcium phosphate, hydroxyapatite or calcium triphosphate, the bodies themselve..

BACILLUS BASED DELIVERY SYSTEM AND METHODS OF USE

Herein a Bacillus exosporium antigen delivery (BEAD) system that provides a means to introduce recombinant proteins or small molecules into the exosporium of members of the B. cereus family of bacteri..

HIGH-THROUGHPUT AND NON-INVASIVE METHOD TO VITRIFY PORCINE EMBRYOS

The present invention provides a practical, non-invasive, and efficient method for cryopreservation of an in-vitro-produced porcine embryo. The inventive method treats the IVP (such as IVF- or NT-deri..

METHODS FOR AMELIORATING ADVERSE EFFECTS ASSOCIATED WITH TRANSFUSION OF AGED RED BLOOD CELLS

The present invention provides, inter alia, methods for ameliorating an adverse effect in a patient caused by an acute transfusion into the patient of a composition containing aged red blood cells usi..

MODULATION OF PHOSPHOLIPASE D FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS

The present invention relates to methods of treating neurodegenerative diseases comprising administering, to a subject in need of such treatment, one or more agent that inhibits or reduces the action,..

ANTIMICROBIAL COMPOSITIONS CONTAINING LOW CONCENTRATIONS OF BOTANICALS

The present invention relates to a preservative or antimicrobial compositions with broad spectrum antimicrobial activity comprising low concentrations of essential oil (and/or one or more component th..

POLYAMINE INHIBITORS FOR THE TREATMENT AND PREVENTION OF PARKINSON'S DISEASE

Disclosed herein are methods for treating a disease involving a-synucleic aggregation using (1) a compound which reduces the amount of polyamines in an amount effective to reduce a-synucleic aggregati..

SHH REGULATION AND METHODS THEREOF

The invention provides for methods of upregulating endogenous GDNF by inhibiting Shh signaling. The invention further provides a method for increasing the production of cholinergic neurons and dopamin..

TREATMENT OF DISEASES WITH ALTERED SMOOTH MUSCLE CONTRACTILITY

The present invention provides, inter alia, methods and compositions for treating or ameliorating the effects of a disease characterized by altered smooth muscle contractility, such as e.g., asthma.

SYNERGISTIC TRANSCRIPTION MODULES AND USES THEREOF

The invention provides for methods for treating nervous system cancers in a subject. The invention further provides methods for treating nervous system tumor cell invasion, migration, proliferation, a..

METHODS OF DIAGNOSING, PREVENTING AND TREATING BONE MASS DISEASES

The present invention provides methods and therapeutic agents for lowering or increasing serum serotonin levels in a patient in order to increase or decrease bone mass, respectively. In preferred embo..

COMPOSITIONS AND METHODS OF TREATING CHRONIC PAIN BY ADMINISTERING PROPOFOL DERIVATIVES

Compositions and methods for managing or treating chronic pain are provided. More particularly, methods are provided for managing or treating chronic pain by administering to a patient in need thereof..

Regeneration of endogenous myocardial tissue by induction of neovascularization

This invention provides a method of treating a disorder of a subject's heart involving loss of cardiomyocytes which comprises administering to the subject an amount of an agent effective to cause card..

CORONARY SINUS CANNULA WITH LEFT VENTRICLE LEAD AND PRESSURE TENT

Techniques for biventricular pacing include a rigid shaped stylet approximating curves of a coronary sinus and branch vein. Some techniques include a parasternal coronary sinus cannula comprising an o..

METHODS FOR ASSESSING THE IMMUNE SYSTEM IN A PATIENT

Methods of determining the onset or susceptibility of an immunological disease are provided herein. Also provided are immunoassay techniques for carrying out such methods.

COMPOSITIONS AND METHODS FOR WOUND TREATMENT

Provided herein are compositions, methods, systems, and kits for wound healing. As shown herein, CCN2/CTGF stimulated mesenchymal progenitor cells can form aSMA- fibroblasts. Further, TGF was shown to..

TREATMENT OF OPHTHALMIC CONDITIONS WITH FLUORENONE DERIVATIVES

Provided are compositions and methods for treatment of ophthalmic conditions, such as retinal detachment and age-related macular degeneration. Various fluorenone derivatives described herein can stimu..

METHODS AND COMPOSITIONS FOR TREATING T-CELL LEUKEMIA

The present invention relates to compositions and methods that may be used to diagnose and treat cancer, particularly T-cell leukemia. According to one preferred embodiment of the present invention, m..

COMPOUNDS AND METHODS FOR TREATING AND PREVENTING EXERCISE-INDUCED CARDIAC ARRHYTHMIAS

The present invention provides a method for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject, a method for treating or preventing exercise-induced cardiac arrhythmia ..

COMPOUNDS AND METHODS FOR INHIBITING SEROTONIN SYNTHESIS

Compounds having the structures below that are TPH1 inhibitors are provided: The compounds are useful for lowering serum serotonin levels in a patient in need thereof, e.g., to increase bone mass. In ..

RAGE REGULATES ROCK ACTIVITY IN CARDIOVASCULAR DISEASE

A method is provided for treating a RAGE-related disorder in a subject afflicted therewith comprising administering to the subject a therapeutically effective amount of an antagonist of rho-associated..

TURKEY VIRAL HEPATITIS VIRUS AND USES THEREOF

The invention is directed to a isolated a Turkey Viral Hepatitis picornavirus-like viruses associated with Turkey viral hepatitis, and isolated nucleic acids sequences and polypeptides thereof. The in..

Use of a melanoma differentiation associated gene (mda 7) for reversing a cancerous phenotype

This invention provides a method for reversing the cancerous phenotype of a cancer cell by introducing a nucleic acid having the melanoma differentiation associated gene (mda-7) into the cell under co..

NGAL-BINDING SIDEROPHORES AND USE THEREOF TO TREAT IRON DEFICIENCY AND IRON OVERLOAD

The invention provides compositions comprising a lipocalin, such as NGAL, and a mammalian siderophore that are useful as iron chelators and iron donors. The invention also provides mammalian sideropho..

HUMAN NOTCH3 BASED FUSION PROTEINS AS DECOY INHIBITORS OF NOTCH3 SIGNALING

This invention provides a fusion protein comprising a signal peptide, EGF repeats 1-X of the extracellular domain of human Notch3 receptor protein wherein X is any integer from 12 to 34, and an Fc por..

Di- und Triphosphat-Prodrugs, insbesondere Nukleosiddi- und -Triphosphat-Prodrugs

The invention relates to a propharmaceuticals useful compounds, pharmaceutical compositions produced therefrom, and drug and pharmaceutical dosage forms and a process for preparing the compounds of th..

Novel ansamitocin derivatives

This invention relates to the field of biologically active compounds and specifically to novel ansamitocin derivatives, pharmaceutical compositions comprising these novel ansamitocin derivatives, meth..

NOVEL ANSAMITOCIN DERIVATIVES

Provided are among other things ansamitocin derivatives, pharmaceutical compositions comprising these novel ansamitocin derivatives, methods for the production of the ansamitocin derivatives and their..

TREATMENT AND PROPHYLAXIS OF EPILEPSY AND FEBRILE SEIZURES

Provided are methods for treatment and prophylaxis of convulsive disorders and seizures, such as epilepsy and febrile seizures, by modulating TRPVl channel activation.

DIAGNOSING, PROGNOSING, AND EARLY DETECTION OF CANCERS BY DNA METHYLATION PROFILING

A method of employing DNA methylation analysis for the diagnosis, prognosis, and prediction of cancer.

COMPOSITIONS AND METHODS FOR CARDIAC TISSUE REPAIR

The invention features compositions comprising agents having cardiac protective activity isolated from epicardial progenitor cells and derivatives thereof, and methods for the use of such compositions..

COMPOSITIONS AND METHODS FOR TISSUE REPAIR

The invention features compositions comprising mesenchymal stem cells or multipotent stromal cells, agents secreted by such cells in culture, and methods featuring such cells for the repair or regener..

RIBONUCLEASE AND THIAZOLIDINEDIONE COMPOUNDS AND THEIR USE IN METHODS TO TREAT CANCER

The present invention relates to methods and kits for the treatment of cancer. A novel drug combination comprising a ribonuclease compound and a thiazolidinedione compound has been identified as produ..

CCL18 AND CCL3 METHODS AND COMPOSITIONS FOR DETECTING AND TREATING CANCER

The invention relates to methods of treating cancer by administering one or more chemokines that are downregulated in cancerous cells. More specifically, the invention provides methods for treating or..

PROSTHETIC LUNG

A prosthetic lung for receipt by a lung space of a patient includes a mass exchange apparatus for use in blood/air mass exchange, an air sac and an air vessel. The mass exchange includes plural blood ..

ANDROGEN RECEPTOR RELATED METHODS FOR TREATING BLADDER CANCER

Disclosed are compositions and methods for treating bladder cancer.

METHODS FOR THE TREATMENT OR PREVENTION OF HEMORRHAGIC CONDITIONS

The present invention relates to a method for treatment or prevention of a hemorrhagic condition in a patient by administering plasminogen activator inhibitor-1 ("PAI-1") and/or an inhibitor of deubiq..

PROTECTING AND REPAIRING CARTILAGE AND MUSCULOSKELETAL SOFT TISSUES

Provided herein are compositions and methods related to promoting protection or repair of articular cartilage and/or musculoskeletal soft tissue by contacting the cartilage, tissues or cellular compon..

TARGETING OF HISTONE DEACETYLASE 2 AND PROTEIN KINASE CK2 FOR TREATMENT OF INFLAMMATORY DISEASES

Methods for the treatment or prevention of diseases which are caused by the degradation of histone deacetylase 2 (HDAC2) in cells are described. The diseases which may be treated by the methods of the..

METHODS AND COMPOSITIONS RELATED TO AGLYCOSIDIC ESCULENTOSIDE A

Disclosed are compositions related to water soluble selective COX-2 inhibitors and methods of using the inhibitors (including h-EsA and derivatives thereof.)

METHODS AND COMPOSITIONS FOR THE TREATMENT OR PREVENTION OF PATHOLOGICAL CARDIAC REMODELING AND HEART FAILURE

The invention relates to methods of treating or preventing pathological cardiac remodeling and/or preventing heart failure. These methods include the administration of a PDEl inhibitor to a patient un..

METHODS AND COMPOSITIONS FOR TREATING INFLAMMATORY CONDITIONS

The present invention is directed to methods of treating an inflammatory condition in a patient. This method includes providing a therapeutic agent that is a vascular endothelial growth factor recepto..

MOLECULAR TARGETS FOR TREATMENT OF INFLAMMATION

Molecular targets and methods for treating inflammatory disorders are described. The expression and/or functionality of molecular targets RelB or SIRT1 is modified in order to treat inflammatory disor..

USE OF ELECTROPHILIC COMPOUNDS FOR INDUCING PLATELET PRODUCTION OR MAINTAINING PLATELET FUNCTION

The present invention is directed to a method of inducing platelet production that includes contacting a megakaryocyte with an electrophilic compound under conditions effective to induce platelet prod..

PARATHYROID HORMONE TREATMENT FOR ENHANCED ALLOGRAFT AND TISSUE-ENGINEERED RECONSTRUCTION OF BONE DEFECTS

Methods of improving an outcome of a bone allograft procedure in a subject suffering from a massive bone defect are described, including providing a bone allograft to the subject and intermittently pr..

METHODS AND COMPOSITIONS RELATED TO TR4 LIGAND

Disclosed are compositions and methods related to TR4 and aging.

USE OF BILIVERDIN REDUCTASE (BVR) AND BVR PEPTIDE FRAGMENTS TO TREAT CORONARY DISORDERS

The present invention relates to methods and compositions for treating coronary disorders and preventing cardiac cell death that involve the use of biliverdin reductase ("BVR") or BVR peptides to stab..

METHODS OF MODIFYING P53 ACETYLATION AND TREATING CANCER USING AVRA

The present invention relates to methods and compositions for the treatment of cancer. The methods and compositions involve the use of the Salmonella effector protein AvrA, as well as variants or frag..

ABERRATION CONTROL BY CORNEAL COLLAGEN CROSSLINKING COMBINED WITH BEAM-SHAPING TECHNIQUE

Corneal collagen crosslinking is used to alter a characteristic of the cornea, such as thickness or refractive index, to correct wavefront aberrations, including higher-order aberrations. A scanning l..

METHODS OF DIAGNOSING AND TREATING FIBROSIS

The present invention is directed to methods of diagnosing and treating a fibrotic condition in a mammalian subject. These methods involve measuring the levels of trimethylation at lysine residue 27 o..

Compositions that inhibit proliferation of cancer cells

The present invention relates to compositions and methods for reducing the proliferation of cancer cells through targeted interactions with integrin.

FIBROBLAST GROWTH FACTOR (FGF) ANALOGS AND USES THEREOF

The invention relates to novel peptide comprising FGF-P and methods of use thereof.

METHOD FOR MODIFYING THE REFRACTIVE INDEX OF OCULAR TISSUES

A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive str..

METHODS OF TREATING INFLAMMATORY INTESTINAL DISEASE AND MANAGING SYMPTOMS THEREOF

Methods and products are disclosed for treating an inflammatory intestinal disease in a mammalian subject in need thereof, or preventing or reducing a symptom of inflammatory intestinal disease. These..

METHOD OF GENERATING ?0 CELLS

Described is a method of the generation of ? DEG cells using a mitochondrial targeted restriction endonuclease. This method comprises (a) transfecting cells with an expression vector containing a gene..

METHOD AND KIT FOR THE EX VIVO EVALUATION OF THE RESPONSE OF A TUMOR TO CONDITIONS TO BE TESTED

The invention concerns a method and kit for the ex vivo evaluation of the response of a tumor to conditions to be tested, in particular a tumor treatment regime, in an isolated tumor sample. The diagn..

CANCER TREATMENT WITH GAMA-SECRETASE INHIBITORS

Provided are methods for treating cancer in a patient, comprising administering to a patient in need thereof a therapeutically effective regimen, the regimen comprising administering a gamma-secretase..

IMMUNOTHERAPY FOR CONTACT DERMATITIS USING CO-SIGNAL REGULATION

Compounds, compositions and methods for immunotherapy in contact dermatitis. Compounds and compositions (e.g. monoclonal antibodies) that stimulate the LAIR-1 expression pathway in LAIR-1 expressing i..

INHIBITORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO

The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway..

COMPOSITIONS AND METHODS FOR TREATING HEPATIC NEOPLASIA

The present invention provides compositions and methods featuring miR-26 microRNA polynucleotides for the diagnosis, treatment or prevention of hepatic neoplasia.

Peroral transgastric endoscopic techniques

Methods and apparatus for accessing the peritoneal cavity and for ligation of fallopian tubes. A representative method includes using an endoscope to orally access a gastric wall. The gastric wall is ..

METHODS OF PROMOTING MUSCLE GROWTH

The present invention relates to use of the interaction of myostatin with the activin type II receptors, and more specifically to use of soluble ACVR2 to increase muscle growth in a subject. As such, ..

COMPOSITIONS AND METHODS FOR ENHANCING ANTIGEN-SPECIFIC IMMUNE RESPONSES

Methods for treating or preventing recurrence of hyper proliferating diseases, e.g., cancer, are described. A method may comprise priming a mammal by administering to the mammal an effective amount of..

COMPOSITIONS AND METHODS FOR INACTIVATION OF PATHOGENS AT GENITAL TRACT SURFACES

The present disclosure includes compositions and methods of inactivating pathogens of a genital tract of a female. The compositions include L-lactic acid substantially free of D-lactic acid. In partic..

TARGET FOR THERAPY OF COGNITIVE IMPAIRMENT

PROBLEM TO BE SOLVED: To provide a method of identifying a gene associated with a desired behavior in a mammal. ; SOLUTION: The method of identifying a gene associated with the desired behavior in a m..

METHODS FOR PROTECTING THE SKIN FROM RADIATION INSULTS

The present invention relates to methods and compositions for the protection of skin and mucous membranes from undesirable side effects of ionizing radiation in a patient undergoing ionizing radiation..

CANCER IMMUNOTHERAPY WITH A VIRAL ANTIGEN-DEFINED, IMMUNOMODULATOR-SECRETING CELL VACCINE

A human cell line, which lacks major histocompatibility class I (MHC-I) antigens and major histocompatibility class II (MHC-II) antigens and which has been modified to comprise and express (i) a nucle..

PHOTOINITIATED TISSUE FILLER

Visible light-activated polymer cosmetic filler preparations useful in a variety of applications are provided. In some embodiments, the photo-activated polymer composition comprises a conventional pol..

GOLD (III) COMPLEXES WITH OLIGOPEPTIDES FUNCTIONALIZED WITH SULFUR DONORS AND USE THEREOF AS ANTITUMOR AGENTS

The invention concerns Au(III) complexes of the type [AuIIIX2(Pdtc)] (X = halogen, pseudo-halogen; pdtc = peptide-/esterified peptidedithiocarbamato) which are able to both maintain the antitumor prop..

METHODS OF TREATING CANCER WITH CD11B ANTIBODIES

Methods and compositions for treating cancer with CD11b antibodies are disclosed. The antibodies may be WT.5 antibodies or compete with WT.5 antibodies, and induce apoptosis in SKOV, MDAH-2774, or BxP..

ERYTHROCYTE ATP-RELEASE MODULATORS

Erythrocyte ATP-release modulators and composition and methods for their use to potentiate serum glucose clearance and vasodilation; methods for prophylactic or palliative therapy of glucose processin..

MONOPHOSPHORYLATED LIPID A DERIVATIVES

The present invention provides for monophosphorylated lipid A derivatives and carbohydrate derivatives that are useful as agents in the treatment of diseases and conditions, including cancers. Also pr..

LIGHT THERAPY TREATMENT

An exemplary method includes selecting at least one light source configured to generate light at a particular wavelength and applying the light to tissue following an ischemic event. Applying the ligh..

Medicament for Treating Problems Relating to Fertility and Pregnancy, and Autoimmune Diseases, and for Inducing an Immunological Tolerance in Transplant Patients, and Method for Producing Said Medicam

A medicament for treating pregnancy disorders or for inducing an immunological tolerance in patients with autoimmune diseases or transplantation processes, contains at least one each of a) a precursor..

Cell culture medium and method for culturing stem cells and progenitor cells

The invention relates to a stem cell culture medium that is deficient in both glucose and inositol. As expected most cells die rapidly as in media deficient in both glucose and inositol. However, in p..

USE OF THE OPPOSITE CELL DIFFERENTIATION PROGRAM (OCDP) FOR THE TREATMENT OF DEGENERATED ORGANS IN THE PATHOLOGICAL STATE

The present invention relates to a method for the treatment of organs which are degenerative and /or in the pathological state by means of the use of cells, which are phenotypically stably differentia..

PHARMACEUTICAL AGENT FOR THE TREATMENT OF FERTILITY AND GESTATION DISORDERS, IMMUNOLOGICAL DISEASES, AND TRANSPLANTATION FOR USE IN VETERINARY MEDICINE, PARTICULARLY IN HORSES, AND METHODS FOR THE PRO

The invention relates to pharmaceutical agents for the treatment of fertility and pregnancy disorders, and immunological diseases (autoimmune diseases) and transplantation, and a method for the produc..

AURORA KINASE INHIBITORS COMPOUNDS.

The present invention relates to novel compounds of formula (I) that inhibit cell proliferation, in particular by inhibiting selectively Aurora A kinase activity and to their use in medicine, in parti..

NEW RAC1 INHIBITORS AS POTENTIAL PHARMACOLOGICAL AGENTS FOR HEART FAILURE TREATMENT

The present invention finds application in the field of medicine and, in particular, to new compounds particularly active in inhibiting Rac1 member of the Rho family. Pharmaceutical preparations conta..

Treatment and Diagnostic Methods for Fibrosis Related Disorders

The present invention relates to the ability of SAP to suppress fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress fibrocytes. Methods and ..

WATER-SOLUBLE CARBON NANOTUBE COMPOSITIONS FOR DRUG DELIVERY AND MEDICINAL APPLICATIONS

Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments...

WATER-SOLUBLE CARBON NANOTUBE COMPOSITIONS FOR DRUG DELIVERY AND MEDICAL APPLICATIONS

System and method for intra-body communication

A method comprising generating a mechanical signal in a mammal, the mechanical signal having a frequency no more than 50,000 Hz, transmitting the mechanical signal through the musculoskeletal system i..

METHOD FOR MEASURING DISEASE PROBABILITY

Methods comprising providing a tissue sample, providing a first imaging device comprising a white light imaging device; providing a second imaging device comprising at least one imaging device selecte..

A DECELLULARIZATION METHOD FOR SCAFFOLDLESS TISSUE ENGINEERED ARTICULAR CARTILAGE OR NATIVE CARTILAGE TISSUE

Methods for fabricating a tissue-engineered construct comppsing: providing a tissue-engineered construct, wherein the tissue-engineered construct is derived from a xenogenic source; and decellularizin..

SCAFFOLDLESS CONSTRUCTS FOR TISSUE ENGINEERING OF ARTICULAR CARTILAGE

A process for culturing chondrocytes to form constructs which contain higher percentages of cells that retain the chondrocytic phenotype are disclosed. The tissue engineered constructs may be formed i..

UNIQUE DUAL-ACTION THERAPEUTICS

A new family of therapeutics which provides a controlled-release delivery platform for non-steroidal anti-inflammatory agents on an ester or an ester-carbonate backbone is disclosed herein. These agen..

TREATMENT OF DISORDERS ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 35 (GPR35)

Compounds are provided having agonistic activity against G protein- coupled receptor 35 (GPR35). The compounds are useful for providing antinociception, providing neuroprotection in case of stroke or ..

LEPTIN ANTAGONIST AND METHODS OF USE

This invention provides compounds that are true antagonists of the leptin receptor, in the presence and the absence of native leptin or another leptin receptor binder. These compounds may be used to i..

ANGIOCIDIN INHIBITION OF TUMOR CELL GROWTH

Methods are presented for the therapeutic administration of angiocidin in the treatment of cancers such as glioma, breast cancer, and leukemia. Methods are also presented for inducing growth arrest an..

Treatment of proliferative disorders with amino-substituted (E)-2,6- dialkoxystyryl 4-substituted benzylsulfones

Methods of treating cancer using compounds according to Formula (I) are disclosed herein, wherein X, X1, X2, Ra, R1, R2, R3, R4, R5, R6, R7, g, M, y, a, b, d, e, V, W, Z and Q are as defined herein.

LEPTIN AGONIST AND METHODS OF USE

Peptides are provided having leptin receptor agonist activity. The peptides are useful for treating obesity, insulin resistance, lipodystrophy and hypothalamic amenorrhea, anorexia-related infertility..

BLOOD MONOCYTE CD163 EXPRESSION AS A BIOMARKER IN HIV-1 INFECTION AND NEUROAIDS

The invention provides a method for detecting CD163+/CD16+ cell population in peripheral blood mononuclear cells in a biological sample from a subject infected with HIV-1 which comprises contacting th..

ENGINEERED DENDRITIC CELLS AND USES FOR THE TREATMENT OF CANCER

This invention provides the field of therapeutics. Most specifically present invention provides methods of generating in vitro engineered dendritic cells conditionally expressing interleukin-12 (IL- 1..

VIRUS DERIVED ANTIMICROBIAL PEPTIDES

Described herein are peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides, designated LBU, WLBU and WR, are analogs of the Lentivirus Lytic Peptide 1 (LLP1) amin..

NITRATED-FATTY ACIDS MODULATION OF TYPE II DIABETES

Nitro oleic acid and related metabolites are agonists of PPAR-?. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-?, relative to nitro linoleic acid. Thus, nitro oleic acid and its meta..

METHODS FOR HEAT SHOCK PROTEIN DEPENDENT CANCER TREATMENT

The present invention provides a method of treating an Hsp70 dependent cancer, including: providing at least one Hsp70 dependent cancer cell; contacting the at least one cell with a sub-effective conc..

SURFACTANT-BASED ANTIMICROBIAL SOLUTION FOR INHALATION

A surfactant can be added, safely and effectively, to a drug solution containing any antimicrobial agent, such as an antibiotic like tobramycin, that is suitable for administration to the lungs via in..

RADIOPROTECTIVE AGENTS

Provided herein are methods, for reducing, preventing, mitigating and treating damage caused by radiation. The methods comprise delivering a compound, as described herein, to a patient in an amount an..

ADMINISTRATION OF AN ADSORBENT POLYMER FOR TREATMENT OF SYSTEMIC INFLAMMATION

The invention provides a method of ameliorating systemic inflammation in a patient involving administering to the patient a therapeutically effective dose of composition including polystyrene divinyl ..

METHODS AND COMPOSITIONS FOR REGULATING TH2 AND TH17 RESPONSES

Methods are provided for treating diseases, such as asthma, inflammatory bowel disease, autoimmune disease and cancers in which IL-6 production by dendritic cells is elevated. Dendritic cell c-Kit sig..

LYMPH NODES AS A SITE FOR REGENERATION

Methods of transplanting cells, such as hepatocytes, are presented herein. Such methods are useful for treating liver disease as well as other disorders.

Vocal Cord Augmentation Utilizing Muscle-Derived Progenitor Compositions, and Treatments Thereof

The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment vocal cord tissue following introduction (..

METHODS OF TREATING DISORDERS ASSOCIATED WITH PROTEIN POLYMERIZATION

The present invention relates to methods of treatment of clinical disorders associated with protein polymerization comprising administering, to a subject, an effective amount of carbamazepine, oxcarba..

FATTY ACIDS AS ANTI-INFLAMMATORY AGENTS

Compounds of formula I and their metabolites are potent mediators of an inflammatory response: (I) where a, b, c, d, e, f, V, W, X, Y, Ra, Ra', Rb, Rb', Rc, and Rc'are defined herein. In particular, t..

REMOVAL OF OXYGEN FROM BIOLOGICAL FLUIDS

A system for reducing the concentration of oxygen in a fluid including red blood cells includes a housing, a plurality of hollow tubes extending within the housing and adapted for flow of the fluid th..

ESTROGEN ANTAGONISTS AS TREATMENTS FOR SCLEROSING DISORDERS

The present invention relates to methods and compositions for treating a subject suffering from a sclerosing disorder, comprising administering, to the subject, an effective amount of an estrogen rece..

USE OF TARGETED NITROXIDE AGENTS IN BONE HEALING

Provided herein are compositions and related methods useful for accelerating bone healing and growth. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. Th..

BLOOD VESSEL SEGMENTATION WITH THREE-DIMENSIONAL SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY

In the context of the early detection and monitoring of eye diseases, such as glaucoma and diabetic retinopathy, the use of optical coherence tomography presents the difficulty, with respect to blood ..

CONSTITUTIVE ANDROSTANE RECEPTOR (CAR) AS A THERAPEUTIC TARGET FOR OBESITY AND TYPE TWO DIABETES

The invention provides a method of controlling obesity or type two diabetes in a human. In accordance with the inventive method, the constitutive androstane receptor (CAR) is agonized within the human..

ANTI-HMG MONOCLONAL ANTIBODIES AND COMPOSITIONS CONTAINING THE SAME

Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositio..

STABLE LIPID-COMPRISING DRUG DELIVERY COMPLEXES AND METHODS FOR THEIR PRODUCTION

Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produ..

URINARY BIOMARKERS FOR PREDICTING LONG-TERM DIALYSIS

This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dial..

METHODS OF TREATING DISORDERS ASSOCIATED WITH PROTEIN AGGREGATION

The present invention relates to methods of treatment of clinical disorders associated with protein aggregation comprising administering, to a subject, an effective amount of an anti- protein aggregat..

COMPOSITIONS AND METHODS FOR DETECTING CANCER

The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and diagnosing ..

USE OF ENDOSTATIN PEPTIDES FOR THE TREATMENT OF FIBROSIS

C-terminal endostatin polypeptides are disclosed herein. These polypeptides include or consist of at least at least 40 consecutive amino acids of the amino acid sequence set forth as amino acids 133-1..

MATRICRYPTIC ECM PEPTIDES FOR TISSUE RECONSTRUCTION

Chemoattractant polypeptide compounds for progenitor cells and compositions and drug products comprising the compounds are provided herein. Methods for attracting progenitor cells to a location in or ..

DEVICES, SYSTEMS AND METHODS FOR CELL MODIFICATION

A method of modifying cells includes removing fluid including cells from a patient, contacting the removed fluid from the patient with at least one surface upon which at least one agent to interact at..

NON-INVASIVE METHOD TO TREAT UROLOGICAL AND GASTROINTESTINAL DISORDERS

Provided herein are methods and devices useful for inhibiting or treating urological conditions, such as overactive bladder (OAB) symptoms including bladder overactivity, urinary frequency, urinary ur..

METHOD FOR TREATING ALCOHOLIC HEPATITIS

Disclosed is a method for treating acute alcoholic hepatitis in a subject. The method comprises the step of administering to the subject an effective amount of an ester of an alpha-ketoalkanoic acid o..

Wortmannin Analogs and Method of Using Same

Wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment of cancer and tumour formation in a subject are described herein. The wortmannin analogs have utility i..

BONE SUBSTITUTE COMPOSITIONS, METHODS OF PREPARATION AND CLINICAL APPLICATIONS

The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium phosphate, ac..

FUNCTIONAL NEAR-INFRARED SPECTROSCOPY AS A MONITOR FOR DEPTH OF ANESTHESIA

Disclosed are methods and devices for measuring a state of anesthesia in a noninvasive manner. Optical techniques may be used to measure changes in a functional near-infrared (fNIR) signal, where the ..

TISSUE JOINING DEVICE AND INSTRUMENT FOR ENABLING USE OF A TISSUE JOINING DEVICE

A tissue joining device and a surgical instrument for employing the tissue joining device are provided. The tissue joining device may be designed such that a first member may be inserted into a second..

Local Delivery System for the Chemotherapeutic Drug Paclitaxel

The present invention provides methods for producing a semi-degradable polymeric composite drug delivery device for localized delivery of chemotherapeutic agents to be used in conjunction with total v..

Dual Inhibitors of HIV-1 GP-120 Interactions

Compounds, which inhibit the binding of gp120 to CD4 as well as 17b and methods for their use in inhibiting the HIV fusion process, are provided.

METHODS AND DEVICES FOR TREATING SURFACES WITH SURFACE PLASMA

Methods and devices for treating surfaces of objects using a non-thermal plasma are disclosed herein. The non-thermal plasma is generated through the use of an apparatus configured to generate a non-t..

ARTICLES AND METHODS FOR REPAIRING DAMAGED NERVOUS TISSUE

The invention concerns substrates comprising a biocompatible gel and at least one of a plurality of cells, said cells being capable of producing at least one therapeutic agent. Other aspects of the in..

PHYSICAL THERAPY SYSTEMS AND METHODS

The invention is directed to a physical therapy system including a glove with a set of acoustic sensors and a positive feedback system and method for teaching finger extension. The system may also inc..

TRICYCLIC COMPOUNDS HAVING CYTOSTATIC AND/OR CYTOTOXIC ACTIVITY AND METHODS OF USE THEREOF

The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase and/o..

Methods for treating cancer by inhibiting mitosis using pyrrolo[2,3-d]pyrimidines

A compound having the following formula: wherein X is selected from the group consisting of a C1 to C6 alkyl group, a heteroalkyl group, a substituted or unsubstituted aryl group, a substituted or uns..

ANTIRETROVIRAL DRUG FORMULATIONS FOR TREATMENT OF CHILDREN EXPOSED TO HIV/AIDS

The present disclosure provides fast disintegrating formulations for the treatment of human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) in patients such as neonatal, pe..

CORNEA RESHAPING

A corneal reshaping kit may include a mold defining a concavity that is sized and shaped for receiving an outer corneal surface, such that a corneal surface pressed against the concavity will adopt a ..

METHOD AND DEVICE FOR TREATING CARDIAC ARRHYTHMIAS

The present invention provides both methods and devices for termination of arrhythmias, such as ventricular or atrial tachyarrhythmias. The device and method involves application of alternating curren..

INHIBITORS OF METHIONINE AMINOPEPTIDASES AND METHODS OF TREATING DISORDERS

The invention is directed towards novel naphthoquinone and naphthothiazole compounds, and methods of treating disorders related to MetAP, including tuberculosis and bacterial infection, using various ..

METHODS FOR ENHANCING ANTIGEN-SPECIFIC IMMUNE RESPONSES

Methods for delivering naked DNA vaccines to enhance immune responses, by improving transfection efficiency without safety concerns associated with live viral vectors, are described. A method may comp..

TRUNCATED ACTIVIN TYPE II RECEPTOR AND METHODS OF USE

The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In additio..

NOVEL LIVER-TARGETING AGENTS AND THEIR SYNTHESIS

This invention provides novel liver targeting agents and their synthetic methods. A liver targeting agent, with a lysine based nitrilo triacetic acid structure as backbone which acquires multivalency ..

CONSENSUS SEQUENCE FOR INFLUENZA A VIRUS

Pandemic A(H1N1) continues its global spread, and vaccine production is a serious problem. Protection by current vaccines is limited by the mutational differences that rapidly accumulate in the circul..

REPROGRAMMING BLOOD CELLS TO PLURIPOTENT AND MULTIPOTENT STEM CELLS

The present invention is based on the seminal discovery that cord blood (CB) and adult bone marrow (BM) CD34+ cells can be reprogrammed to early stem cells. The invention provides the reprogramming of..

NON-INVASIVE METHODS AND SYSTEMS FOR ASSESSING CARDIAC FILING PRESSURE

Featured are methods and systems for assessing cardiac filing pressure non- invasively. Such methods include, inter alia, arranging a photoplethysmography (PPG) transducer on a finger of a patient and..

THE FUNGAL SREBP PATHWAY AS A TARGET FOR ANTI-FUNGAL AGENTS

Inhibition of Srel activity and/or expression has great potential for antifungal therapeutics. Disclosed herein are novel methods and compositions useful for the identification of novel inhibitors of ..

LYSINE-SPECIFIC DEMETHYLASE INHIBITORS

Polyamine, polyamine/guanidino, and polyamine/biguanide compounds bearing allene, propargyl, cyclopropyl, and other reactive moieties are disclosed. The compounds are useful as irreversible inhibitors..

Method For Identifying and Validating Dominant T Helper Cell Epitopes Using An HLA-DM-Assisted Class II Binding Assay

Rational design of immunotherapeutics relies on clear knowledge of the immunodominant epitopes of antigens. Current methods for identifying kinetically stable peptide-MHC complexes are in many cases i..

COMBINATION THERAPY FOR TUBERCULOSIS

The present invention relates to methods of treating tuberculosis, including multi not drug resistant varieties and latent tuberculosis. More particularly, the present invention relates to a method of..

MULTITYPE HPV PEPTIDE COMPOSITIONS AND METHODS FOR TREATMENT OR PREVENTION OF HUMAN PAPILLOMAVIRUS INFECTION.

Embodiments of the invention are directed to methods and compositions of multitype HPV polypeptides.

METHODS FOR TREATING OR PREVENTING BRAIN INFECTIONS

The invention is directed to methods of treating organ specific infections in a host organism by administering compounds that target host receptors and/or host cellular signaling molecules to prevent ..

UNIVERSALLY DEPLOYABLE AND EXPANDABLE BONE SCREW ANCHOR ASSEMBLY

A self-expanding bone screw anchor assembly adapted to allow the screw body to engage the bone and the anchor to attach thereto. The anchor assembly is adapted to be universally deployed with a variet..

LRRK2-MEDIATED NEURONAL TOXICITY

Leucine-rich repeat kinase-2 (LRRK2) mutations are a common cause of Parkinson's disease. Inhibitors of LRRK2 kinase that are protective in in vitro and in vivo models of LRRK2-induced neurodegenerati..

Membrane Associated Tumor Endothelium Markers

To gain a better understanding of tumor angiogenesis endothelial cells (ECs) were isolated and gene expression patterns were evaluated. When transcripts from ECs derived from normal and malignant colo..

METHODS OF SYNTHESIS AND USE OF CHEMOSPHERES

The present invention provides, in general, compositions comprising a hydrogel and an agent, for example a therapeutic agent or an imaging agent, for locoregional delivery. In certain preferred embodi..

HISTONE DEACETYLASE INHIBITORS, COMBINATION THERAPIES AND METHODS OF USE

The invention relates to histone deacetylase (HDAC) inhibitors to treat proliferative diseases. The present invention provides novel class III histone deacetylase inhibitors, in particular SIRT1 inhib..

METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING AUTOIMMUNE DISEASES

Provided are methods and compositions for treating and/or preventing an autoimmune diseases, including inflammatory bowel disease, rheumatoid arthritis, diabetes mellitus, celiac disease, autoimmune t..

HYDROGEL-BASED VASCULAR LINEAGE CELL GROWTH MEDIA AND USES THEREOF

A medium for growing vascular lineage cells is described. The vascular lineage cell growth medium includes an oligosaccharide-based hydrogel and a growth factor that promotes vascularization by vascul..

SYSTEM AND METHOD FOR MACRO-MICRO DISTAL DEXTERITY ENHANCEMENT IN MICRO-SURGERY OF THE EYE

A system for operating within an interior region of the eye, or other organ, includes a delivery channel having a proximal portion located exterior to the eye and a distal portion positionable within ..

Methods of Treating Neurological Autoimmune Disorders with Cyclophosphamide

escribed herein are methods for treating neurological autoimmune disorders in which the treatment method includes administering an immunoablative agent to eliminate most or essentially all maturing an..

DETECTION AND PROGNOSIS OF LUNG CANCER

Methods and tools are provided for detecting and predicting lung cancer. The methods and tools are based on epigenetic modification due to methylation of genes in lung cancer or pre-lung cancer. The t..

Growth differentiation factor receptors, and methods of using same

The present invention provides an activin type IIB receptor (ActRIIB) for use in the treatment or prevention of a muscle disease or disorder in a mammal. The muscle disease or disorder may be muscular..

METHOD FOR LATE INTRODUCTION OF THE (8R)-HYDROXYL GROUP IN CARBAPENEM BETA-LACTAM ANTIBIOTIC SYNTHESIS

The presently disclosed subject matter demonstrates that ThnG and ThnQ enzymes encoded by the thienamycin gene cluster in Streptomyces cattleya oxidize the C-2 and C-6 moieties of carbapenems, respect..

TREATMENT METHODS UTILIZING STEM CELL MOBILIZERS AND IMMUNOSUPPRESSIVE AGENTS

The present invention relates to the field of organ transplantation. In one aspect, the present invention provides methods of treating an organ transplant recipient comprising administering to the rec..

ANTI-CYTOMEGALOVIRUS ACTIVITY OF ARTEMISININ-DERIVED DIMERS

Artemisinin-derived monomers and artemisinin dimers are shown to exhibit in-vitro anti-cytomegalovirus (CMV) activity. Artemisinin dimers effectively inhibited CMV replication in human foreskin fibrob..

SR-BI AS A PREDICTOR OF HUMAN FEMALE INFERTILITY AND RESPONSIVENESS TO TREATMENT

Methods of diagnosis and treatment of diseases and disorders related to de novo synthesis of cholesterol, based on allelic variants of the scavenger receptor class B type I receptor, and kits for use ..

CITRULLINATION OF HUMAN PEPTIDYLARGININE DEIMINASE 4 (PAD-4) REGULATES ITS FUNCTION AND IMMUNOGENICITY

The present invention provides peptidylarginine deiminase 4 (PAD-4) polypeptides comprising one or more citrullinated Arginine sites. In one embodiment, a PAD-4 polypeptide comprises a citrulline resi..

PSMA-BINDING AGENTS AND USES THEREOF

Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, com..

METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION

This invention relates to treating age-related cognitive impairment. This invention in particular relates to the use of inhibitors of synaptic vesicle protein 2A (SV2A), such as levetiracetam, seletra..

COMPOSITIONS AND METHODS FOR ENHANCING TRANSPORT THROUGH MUCUS

The invention generally relates to compositions and methods for transporting substances across mucosal barriers. The invention also relates to methods of making and using such substances.

COMPOSITIONS AND METHODS FOR TREATING CARDIOVASCULAR CONDITIONS

The invention provides amphiphilic macromolecule encapsulates that are useful for treating cardiovascular diseases including conditions related to or emanating from atherosclerosis.

NONTOXIC SHIGA-LIKE TOXIN MUTANT COMPOSITIONS AND METHODS

Disclosed are nontoxic mutants of Shiga-like toxin (Stx1 or Stx2), nucleic acids encoding them, compositions containing the mutants and methods of using the mutants in connection with hemolytic euremi..

SYSTEM AND METHOD FOR LIVER CELL CULTURE AND MATURATION

The present invention relates to systems and methods for maturation, proliferation and maintenance of function in cells presenting hepatocyte characteristics and differentiated from stem cells. The ce..

AMPICILLIN AND AMOXICILLIN-BASED POLY(ANHYDRIDE-AMIDES)

In one aspect the invention relates to an antibacterial compound of formula II: wherein n is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12; R is H or OH; or a salt thereof. In other aspects the invention a..

ENDORPHIN THERAPY COMPOSITIONS AND METHODS

In certain embodiments, the invention provides methods of isolating and culturing neuronal stem cells from hypothalmi, methods of differentiating the neuronal cells into beta-endorphin neurons, and me..

HCV E2 CONSTRUCT COMPOSITIONS AND METHODS

The invention provides a construct comprising the ectodomain of the Hepatitis C virus (HCV) E2 sequence and a mammalian expression system therefore. More particularly, the invention relates to a const..

INHIBITION OF DCPS

The disclosure relates to methods and compositions (e.g., compounds and pharmaceutical compositions thereof) useful for increasing expression of SMN in a cell (e.g., in vitro or in vivo). As a deficie..

COMPOSITIONS AND METHODS FOR TREATING OPHTHALMIC DISEASES

Degradable polymeric compositions containing water-insoluble drugs blended with copolymers of biocompatible diphenol compound monomer units with pendant carboxylic acid groups polymerized with biocomp..

CONTROLLED RELEASE OF ACTIVES IN SKIN.

Topical compositions are provided in which active compounds for topical delivery through the stratum corneum are complexed with nanospheres of a triblock copolymer having an A-B-A structure wherein ea..

Compositions and Methods for Modulating Visceral Sensation and/or Gastrointestinal Reflex Activity

The invention relates to compositions capable of modulating visceral sensation and/or gastrointestinal activity obtained from botanical sources. More specifically, the invention relates to composition..

MICELLE ASSEMBLIES

The invention encompasses micelle assemblies, compositions having micelle assemblies, and methods for preparing micelle assemblies and compositions thereof. Also, the invention encompasses compounds o..

TREATMENT OF OBESITY

The present invention relates generally to a method of increasing lipid oxidation in a mammal and to agents useful for same. More particularly, the present invention relates to a method of increasing ..

X-CHROMOSOMAL VARIATION AS A DIAGNOSTIC AND THERAPEUTIC MARKER FOR THE PROGRESSION TO AIDS

The present invention relates to a method for diagnosing the likelihood and/or speed of AIDS progression in a mammal, comprising the analysis of at least one of the X-chromosomal SNPs from the DXS986 ..

METHOD FOR DETERMINING THE QUALITY OF HEPARIN

The invention relates to a method for determining contamination of heparin with other sulfated glycans, comprising the steps: incubating a predetermined amount of heparin together with a predetermined..

PHARMACEUTICAL COMPOSITIONS FOR TREATING INFECTIONS WITH DRUG RESISTANT MYCOBACTERIA

In a first aspect, the present invention relates to pharmaceutical compositions for the treatment of infections with mycobacteria wherein said mycobacteria are resistant to at least one of the followi..

RNA APTAMERS THAT SPECIFICALLY BIND TO THE SOLUBLE INTERLEUKIN-6 RECEPTOR

The invention relates to aptamers specifically binding to a target molecule. The aim of the invention is to prepare diagnostic and/or therapeutic agents for use in the recognition and/or prevention or..

DNA APTAMERS THAT SPECIFICALLY BIND TO THE SOLUBLE INTERLEUKIN-6 RECEPTOR

The invention relates to aptamers specifically binding to a target molecule. The aim of the invention is to provide diagnostic and/or therapeutic agents for use in the recognition and/or prevention or..

NEUROPROTECTIVE COMPOSITIONS AND METHODS

This disclosure concerns novel methods for preventing or treating neurological or neurodegenerative diseases or disorders by using kombo butter acid enriched extracts derived from the seeds of African..

THERAPEUTIC DEVICES FOR PATTERNED CELL GROWTH

The invention provides therapeutic devices comprising a polymeric anti-inflammatory agent that biodegrades to release anti-inflammatory agents. The therapeutic devices are useful for repair and regene..

PROCESS FOR DESIGNING INHIBITORS OF INFLUENZA VIRUS STRUCTURAL PROTEIN-1

Disclosed are methods and compositions useful in identifying inhibitors of influenza virus, such as influenza A and B virus. Also disclosed are methods for preparing compositions for administration to..

COMPOSITIONS AND METHODS FOR TREATMENT OF NEUROPATHIC PAIN

The present invention relates to compounds, compositions, methods, systems and kits for treating neuropathic pain regulated by SIP30. The present invention provides SIP30 antagonists for the treatment..

METHODS TO TREAT CANCER

The invention provides methods and pharmaceutical compositions for treating certain cancers with compounds of formula (I) wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specific..

DRESSING COMPOSITIONS AND METHODS

Described is a spray-on hydrogel comprising water-soluble PEG polymers that cross-link in situ to form a hydrogel such that the cross-links are reversible. The hydrogel can be useful as a drug deliver..

COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF PROTOZOAN INFECTIONS

Provided are compounds, compositions and methods for treating protozoan infections.

SOLUBILIZED TOPOISOMERASE POISONS

The invention provides compounds of formula I: wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provi..

TREATMENT OF CUTANEOUS HEMANGIOMA

This invention concerns a method of treating hemangiomas with a beta blocker by applying the beta blocker onto the hemangiomas directly. The invention also concerns a combination therapy by using a be..

HIV-1 GP41 NEUTRALIZATION DOMAIN AND USE THEREOF

The invention relates to a region of the HIV-I gp41 protein that contains, at least in part, an epitope that allows potent neutralization of resistant virus particles. This site is present in the C-te..

ANTITOXIN DESTABILIZATION TECHNOLOGY

Disclosed are methods for purifying toxin proteins which avoid denaturation and renaturation procedures.

BENZO [C] PHENANTHRIDINES AS ANTIMICROBIAL AGENTS

The present invention provides compounds of formula I: formula (I) wherein X1- X4 and R1-R12 have any of the values defined in the specification, as well as salts and prodrugs thereof, which inhibit m..

METHODS AND COMPOSITIONS FOR TREATING OBESITY AND RELATED DISORDERS

The invention provides methods for, and compositions effective for, treating obesity, inhibiting weight gain, treating diabetes mellitus, inhibiting atherosclerosis and treating related disorders and ..

BACTERIAL HELICASE INHIBITOR COMPOUNDS AND USES THEREOF

Organic compounds are described that inhibit bacterial helicase activity and growth of bacterial cells on surfaces.

INHIBITING OBESITY PROGRESSION BY INHIBITING ADIPOCYTE DIFFERENTIATION WITH A PRE-ADIPOCYTE AUTOPHAGY INHIBITOR

The present invention relates to methods of mitigating, preventing or treating weight gain or obesity in patients by administering one or more autophagy inhibitors, thereby, preventing the differentia..

METHODS AND COMPOSITIONS FOR TREATING ALZHEIMER'S DISEASE

A method is disclosed for inhibiting the build-up of amyloid plaques in the brain of a patient with at least one risk factor for, or a diagnosis of, Alzheimer's Disease by administering to the patient..

TYPE 5 ADENYLYL CYCLASE INHIBITORS FOR PROVIDING CARDIAC PROTECTION

The invention provides a method of treating a cardiac disease by administering a pharmaceutically effective amount of at least one compound capable of inhibiting AC5 to a patient. The compound capable..

AMNIOPUNCH AND USES THEREOF

A tissue, such as an amniotic or chorionic membrane, harvesting device that integrates a system facilitating subsequent storage of tissue samples. The device cuts a sample of the target tissue and aut..

COMPOSITIONS AND METHODS TO MODULATE CELL MEMBRANE RESEALING

Disclosed herein are compositions and methods for repairing cell membranes. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention i..

MECHANISM-BASED SMALL-MOLECULE PARASITE INHIBITORS

Methods for preventing or treating an Apicomplexan parasite infection in a patient administering to a patient in need thereof an effective amount of a compound of Formulas I- IV.

USE OF STEM CELLS FOR WOUND HEALING

Cells, compositions, and methods of cell therapy for administering a therapeutically effective amount of stem cells or cell concentrate to achieve accelerated wound healing of normal and chronic wound..

CLOSED SYSTEM SEPARATION OF ADHERENT BONE MARROW STEM CELLS FOR REGENERATIVE MEDICINE APPLICATIONS

A method for isolating and processing bone marrow derived stem cells, including the steps of: (a) collecting a biological sample containing adherent bone marrow stem cells in a receptacle with interio..

METHOD FOR TREATING SEPSIS OR SEPTIC SHOCK

The present invention is a method for treating sepsis or septic shock using Lipoxin A4.

TREATMENT OF HIV INFECTION

This invention concerns compositions and methods of treating, inhibiting, or controlling HIV infection.

TREATMENT AND DIAGNOSIS OF INFLAMMATORY DISORDERS

This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders.

METHOD FOR TREATING CHRONIC NERVE TISSUE INJURY USING A CELL THERAPY STRATEGY

A method for treating a degenerative or traumatic injury to a nerve tissue or the brain by administering at or near the injury site a composition containing adherent bone marrow stem cells suspended i..

Medical use of mRNA interferase

The present invention is directed to the discovery of a novel family of enzymes designated herein as mRNA interferases that exhibit endoribonuclease activity. The novel finding of the present inventor..

Hemostatic Effects of Glucono-Delta-Lactone

Glucono-delta-lactone (GDL) can be used to mediate the human blood coagulation process. In particular, GDL can be used in an assay to determine an individual's risk potential for accelerated blood clo..

Method of Treatment for Acute Myelogenous Leukemia

This invention relates to a method of treating acute myelogenous leukemia with TPA along with Dexamethasone and choline magnesium trisalicylate.

COMPOSITIONS AND METHODS MODULATING MG29 FOR THE TREATMENT OF DIABETES

Disclosed herein are compositions and methods for treatment of muscle dysfunction, including diabetes. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or poly..

RNA TARGETING IN ALPHA-SYNUCLEINOPATHIES

Therapies and assays to screen for small molecules that can have therapeutic use in the control of neurodegenerative diseases such as Parkinson's and other alpha-synucleinopathies.

INHIBITION OF QUORUM SENSING-MEDIATED PROCESSES IN BACTERIA

Methods are provided for identifying molecules that can be used to positively and negatively manipulate quorum-sensing-mediated communication to control bacterial behavior. Small-molecule antagonists ..

TREATMENT OF VIRAL INFECTIONS BY MODULATION OF HOST CELL METABOLIC PATHWAYS

Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for in..

METHODS FOR PREDICTING DISEASE OUTCOME IN PATIENTS WITH COLON CANCER

Closures for containers and methods for using same are provided. In a general embodiment/ the present disclosure provides a closure having a top portion (12), a bottom portion (14) and a side portion ..

INHIBITION OF GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE (GPAT) AND ASSOCIATED ENZYMES FOR TREATMENT OF VIRAL INFECTIONS

A method of treating or preventing a viral infection in a mammal by administering a compound or pharmaceutically acceptable derivative thereof that inhibits a phosphatidic acid synthesis enzyme

ANGIOGENIC RESORCINOL DERIVATIVES

Novel resorcinol derivatives and methods of preparation and use are presented. These compounds can stimulate angiogenesis as a biological function triggered by the activation of one cannabinoid recept..

ANTIMICROBIAL COMPOUNDS

This disclosure relates to compositions including certain compounds identified by a quantitative, high throughput assay to be effective in inhibiting the ability of a bacterium to kill a host organism..

METHODS OF TREATING FUNGAL INFECTIONS.

Methods of identifying compounds that potentiate the activity of antifungal agents, potentiators identified by these methods, and methods of using potentiators to treat fungal infections are disclosed..

SYNTHETIC TRITERPENOIDS AND METHODS OF USE IN THE TREATMENT OF DISEASE

The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using s..

METHOD FOR SELECTIVELY INHIBITING THE ACTIVITY OF ACAT1 IN THE TREATMENT OF ALZHEIMER'S DISEASE

The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selec..

FEMALE REPRODUCTIVE TRACT AND ANAL PROPHYLAXES

The present invention provides methods for boosting mucosal immunity in the female reproductive tract of pre- and post -menopausal women using a TGF-beta inhibitor, a Selective Estrogen Receptor Modul..

SYSTEM AND METHOD FOR PROVIDING PATIENT REGISTRATION WITHOUT FIDUCIALS

A method for providing patient registration without fiducials comprises the steps of: spatially placing an ultrasound image of a patient randomly at different starting positions relative to a preopera..

COMPOSITIONS AND METHODS FOR TREATING CANCER

The present invention embraces bis-acridine and bis- quinoline intercalators having a bis (4-aminophenyl) ether tether, and diglycolate salts thereof, for selectively decreasing colon cancer and glial..

COMPOSITIONS AND METHODS FOR TREATING PANCREATIC CANCER

The present invention provides a method of treating pancreatic cancer by inhibiting the activity cyclin D1 activity in tumor cells. The invention is based on the finding that cyclin D1 shRNA molecules..

Compositions and methods for preventing or treating a viral infection

The present invention is a composition for enhancing the immunogenicity of viral vaccine. The composition encompasses a viral vaccine in combination with at least one toll-like receptor and, in partic..

MONOCYCLIC CYANOENONES AND METHODS OF USE THEREOF

The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.

Methods for diagnosing and treating neuroendocrine cancer

The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods fo..

Animal model and compounds identified via this model for treatment of chronic pain

An animal model for chronic pain, and in particular lower back pain, is provided. Methods of identifying agents and reducing chronic pain with identified agents such as methotrexate are also provided...

ABSORBABLE BONE ADHESIVE APPLICATOR

The instant invention provides of a novel method for repairing bone defects using a polymer blend as well as apparatus for performing such a method. The method includes dispensing a polymer blend eith..

SYSTEM AND METHOD FOR IDENTIFICATION OF FINGERPRINTS AND MAPPING OF BLOOD VESSELS IN A FINGER

In accordance with an embodiment of the invention, there is provided an apparatus for characterizing and identifying a human. The apparatus comprises a light imaging device that images topography of a..

Polymeric antioxidants

Antioxidant polymers of the present invention comprise repeat units that include one or both of Structural Formulas (I) and (II): wherein: R is -H or a substituted or unsubstituted alkyl, acyl or aryl..

INHIBITORS OF CYCLIC AMP PHOSPHODIESTERASES

Recombinant fission yeast cells and methods of using them are described, which provide for identification of chemical and biological inhibitors or activators of a target exogenous phosphodiesterase (P..

SH2 DOMAIN PROFILING TO CHARACTERIZE TYROSINE PHOSPHORYLATION SIGNALING IN CANCER

A phosphoproteomic method termed SH2 profiling to characterize phosphotyrosine (pTyr) signaling in lung cancer. This method provides quantitative values for the phosphorylated binding sites for Src Ho..

PROTEIN-BASED ARTIFICIAL RETINAS

Multilayer protein films are provided, which comprise native bacteriorhodopsin and/or specialized bacteriorhodopsin mutants as the photoactive element. Also provided are artificial subretinal and epir..

DIALYSIS ADAPTER CELL AND METHOD OF USE

A dialysis adapter cell includes a housing comprising a plurality of pillars extending between and attached to a top plate and a bottom plate to form a hollow receptacle, wherein the top plate compris..

THERAPEUTIC APPLICATIONS OF FATTY ACID AMIDE HYDROLASE INHIBITORS

Fatty acid amide hydrolase (FAAH) is an enzyme responsible for the degradation of oleamide (an endogenous sleep-inducing lipid) and anandamide (an endogenous ligand for cannabinoid receptors). Disclos..

METHODS OF IDENTIFYING INSECT-SPECIFIC SPIDER TOXIN MIMICS.

Disclosed herein are methods of identifying a candidate molecule that mimics at least a portion of the three-dimensional structure of a rU-ACTX-Hvla insecticidal toxin, the method comprising providing..

Complexes of alpha (2) macroglobulin and antigenic molecules for immunotherapy

The present invention relates to complexes of alpha (2) macroglobulin associated with antigenic molecules for use in immunotherapy. The invention relates to methods for using such compositions in the ..

NOVEL ALBUMIN-FREE FACTOR VIII FORMULATION

PROBLEM TO BE SOLVED: To provide a factor VIII formulation for a treatment that is stable in the absence of albumin or other proteins. ; SOLUTION: The factor VIII composition formulated without adding..

FACTOR VIII FORMULATIONS

A Factor VIII (FVIII) composition formulated such that NaCl is not present in the final formulation or is present in trace amounts, which allows for a concomitant reduction in the lyophilization cycle..

METHODS AND COMPOSITIONS FOR INHIBITING ATHEROSCLEROSIS AND VASCULAR INFLAMMATION

Disclosed herein are compositions and methods for reducing inflammation associated with atherosclerosis and/or vascular inflammatory disease. The methods include administering to a subject in need of ..

COMPOUNDS FOR LYSOSOMAL MODULATION AND METHODS OF USE

Compounds useful for promoting lysosomal processes and thereby ameliorating the disruption of cellular and functional integrity induced by Ass and other protein and glycoconjugate species are provided..

Compositions and Methods for the Inhibition of Hepatitis C Viral Replication with Structural Analogs

Compositions and methods for the inhibition of viral replication are provided. In some embodiments, the compositions include a nucleic acid sequence that is identical to a region of the hepatitis C vi..

USING HEAT SHOCK PROTEINS TO IMPROVE THE THERAPEUTIC BENEFIT OF A NON-VACCINE TREATMENT MODALITY

The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an alpha-2-macroglobulin (alpha2M) preparation with a non-v..

METHOD FOR OBTAINING HUMAN MICROGLIAL PRECURSOR CELLS FROM PLURIPOTENT STEM CELLS

The present invention relates to a method for obtaining human microglial precursor cells, comprising: (a) providing a ceil population comprising neural precursor cells, wherein the cell population is ..

SENSOR ARRANGEMENT

The invention relates to a sensor arrangement for detecting electromagnetic radiation whose wavelength in or near the infrared range, with at least one measuring chamber (2), which is filled with the ..

ANTICANCER AGENT

The present invention relates to a pharmaceutical composition for the therapeutic and/or prophylactic treatment of cancer and/or metastasis thereof comprising an amino acid sequence related to a Wech ..

APPARATUS AND METHOD FOR DETECTING TRIACETONE TRIPEROXIDE

The present invention relates to an apparatus and method for fast and secure online detection of triacetone (TATP).

INHIBITORS OF THE NITRATION OF AMYLOID ss PEPTIDES AND THEIR USES IN THE DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE

The present invention relates to a method for identifying an inhibitor of the aggregation of amyloid-ss peptide (Ass), comprising the steps of a) contacting at least one Ass-peptide and/or the nitrate..

CYTOHESIN INHIBITORS

The present invention relates to a pharmaceutical preparation comprising as an active ingredient a primary amide according to the general formula (1) and/or a secondary amide according to the general ..

New nucleic acid molecules and polypeptides involved in lipid metabolism

The present invention relates in a first aspect to polypeptides useful for the prevention or treatment of various diseases. In particular, the present invention relates to a polypeptide containing a h..

PPAR gamma agonists for treating illnesses with pathophysiological participation of TH17 lymphocytes

Use of one or more peroxisome proliferator-activated receptor (PPAR)-gamma agonists for treating a disease in which T helper 17 (TH17) cells have a pathophysiologically relevant function, is claimed. ..

ADENINE RECEPTOR LIGANDS

The invention relates to adenine receptor ligands useful for treating, alleviating and/or preventing diseases and disorders related to adenine receptor function as well as pharmaceutical compositions ..

Anti-HSV antibody

The invention relates to an anti-HSV antibody as defined in the claims, a pharmaceutical composition comprising of an effective amount of the said antibody, an expression vector comprising of a nucleo..

PHARMACEUTICAL COMPOSITION CONTAINING CANNABINOID-RECEPTOR ANTAGONISTS

The present invention relates to the use of cannabinoid-receptor 2 (CB2R)-antagonists for the prophylaxis and/or treatment of pathogen, in particular, parasitic protozoa, caused or induced cerebral di..

IN-VIVO STIMULATION MEASURING PROBE

The invention relates to a measuring probe and a system for the targeted optical in-vivo stimulation of nerve cells and for the electrical measurement of nerve cell pulses. The measuring probe compris..

ANDROGENETIC ALOPECIA

The present invention relates to methods for testing for a predisposition or presence of androgenetic alopecia comprising testing a sample obtained from a prospective patient or from a person suspecte..

POI Prevention

A method is provided, comprising administering at least one guanylhydrazone or salt thereof or a combination thereof to a subject to prevent or ameliorate in said subject at least one of postoperative..

METHODS AND COMPOSITIONS FOR PROMOTING REGENERATION BY INCREASING INTRACELLULAR SODIUM CONCENTRATION

The invention provides methods and compositions for increasing the intracellular sodium concentration in a cell.

METHOD FOR ASSESSING POTENTIAL FOR TUMOR DEVELOPMENT AND METASTASIS

The present invention generally provides methods for assessing the potential of tumor formation and/or metastasis using a combination (e.g., a ratio) of the number of circulating tumor cells and the n..

ATOXIC RECOMBINANT HOLOTOXINS OF CLOSTRIDIUM DIFFICILE AS IMMUNOGENS

Atoxic Clostridium difficile toxin proteins were expressed in an endotoxin-free Bacillus system top develop a vaccine to reduce incidence and severity of C. difficile infection (CDI). Immunogens evalu..

INHIBITORS OF EXTRACELLULAR HSP90

The present invention describes the inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention rel..

Wound Healing Peptides and Methods of Use Thereof

Methods and compositions for the treatment of wounds in a mammalian subject are provided. Particularly, novel polypeptides and encoding nucleic acids that stimulate keratinocyte and endothelial cell m..

Methods, compositions and kits for vegetative cell-based vaccines and spore-based vaccines

Methods for immunizing a subject to an antigen of an infectious agent, a tumor, or an allergen are provided, using vegetative cytoplasmic expression of the antigen or spore surface display of the anti..

Matrix for the production of ligaments, tendons and other tissue

The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantati..

MULTIVALENT VACCINE VECTOR FOR THE TREATMENT AND INHIBITION OF VIRAL INFECTION

The present invention features compositions and methods for the treatment or inhibition of one or more viruses using a recombinant viral vector that encodes and expresses at least one viral gene from ..

COMPOSITIONS AND METHODS FOR TREATING EBOLA VIRUS INFECTION

The compositions and methods of the invention described herein provide treatments against Ebola virus infection by expressing gene(s) from the Ivory Coast ebolavirus (ICEBOV) species in a recombinant ..

PRE-OR POST-EXPOSURE TREATMENT FOR FILOVIRUS OR ARENAVIRUS INFECTION

The compositions and methods of the invention described herein provide pre- or post-exposure treatments against filovirus or arenavirus infection by expressing one or more genes (e.g., two ore more ge..

POLYMERIC BIOLUBRICANTS FOR MEDICAL USE

The present invention provides branched polymers which can be used as lubricants or shock absorbers in vivo. For example, the inventive polymers can be used as viscosupplements, viscoelastics, tissue ..

SUPRAMOLECULAR BIOCONJUGATES

The invention relates to supramolecular bioconjugates and to methods for assembling and utilizing supramolecular bioconjugates. Supramolecular bioconjugates comprise a plurality of first nucleic acids..

METABOLIC AND CARDIOPROTECTION BY THE MYOKINE FOLLISTATIN-LIKE 1 POLYPEPTIDE

Described herein are methods and compositions related to the discovery that the Follistatin-like 1 protein (Fstl-1) has metabolic and cardioprotective effects in vivo. Fstl-1 and portions and derivati..

IDENTIFICATION OF NOVEL PATHWAYS FOR DRUG DEVELOPMENT FOR LUNG DISEASE

The invention provides the identification of oncogenic pathways activated in cytologically normal airway cells of individuals having or at risk of having lung disease, as well as specific gene express..

KNEE BRACE WITH EXPANDABLE MEMBERS AND METHOD OF USING THE SAME

A knee brace (300) has a body (310) supporting first, second, and third expandable members (330). When expanded, the first, second, and third expandable members are positioned on the brace body to pro..

RECA INHIBITORS AND THEIR USES AS MICROBIAL INHIBITORS OR POTENTIATORS OF ANTIBIOTIC ACTIVITY

The present invention provides RecA inhibitors, compositions containing them, systems for identifying or characterizing them, and methods of using them.

CELL-SPECIFICALLY EFFECTIVE MOLECULES ON THE BASIS OF SIRNA AND APPLICATION KITS FOR THE PRODUCTION THEREOF AND USE THEREOF

1. Cell-specifically effective molecules on the basis of siRNA and application kits for the production thereof and use thereof. 2.1. The aim of the invention is to create a link between siRNA and one ..

METHOD AND DEVICE FOR RAPID DETECTION OF BACTERIAL ANTIBIOTIC RESISTANCE/SUSCEPTIBILITY

Described herein is a method and a device for expediting delivery of an agent to a damaged bacterial cell. In one embodiment, the methods and devices are useful for screening candidate antibiotics. In..

SYSTEM FOR ASSESSING THE EFFICACY OF STORED RED BLOOD CELLS USING MICROVASCULAR NETWORKS

A system for assessing the microvascular fitness of a sample of stored red blood cells. The system has a network device having at least one network unit. The network unit has a single inlet and a sing..

APPARATUS AND METHOD OF ANALYZING ARTERIAL PLAQUE

A method of identifying arterial plaque analyzes arterial plaque using one or more non-invasive tests to determine if the plaque has any of a plurality of hallmarks that are predictive of disruption. ..

PIMAP39 MODULATES INFLAMMATORY RESPONSE

The present invention relates to a novel peptide sequence named PIMAP39 (herein referred to as SEQ ID NO.: 1 ) and methods of use of the novel sequence and functional variants thereof. The present inv..

TETRAHYDROPYRANONAPHTHYRIDINES DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC TREATMENT THEREOF

This invention relates to tetrahydropyranonaphthyridines derivatives having formula (III) or IV: and analogues of the tetrahydropyranonaphthyridines derivatives. The invention also relates to pharmace..

TREATMENT OF IgE-MEDIATED DISEASE

The methods and compositions described herein are based, in part, on the discovery of a polypeptide of soluble CD23 (sCD23) that binds and sequesters IgE. Thus, the sCD23 peptides, polypeptides and de..

DELIVERY OF H2 ANTAGONISTS

The present invention provides improved systems and methods for the local delivery of H2 antagonists. The inventive methods include topical administration of an effective amount of a H2 antagonist enc..

THODS AND COMPOSITIONS FOR PREVENTING ADHESION

This invention provides methods and compositions for preventing post-surgical adhesion formation based on use of an interleukin-16 (IL-16) antagonist, including an IL-16 antagonist peptide and/or an I..

S ISOMERS OF ALPHA-METHYL HYDROCINNAMIC ACID FOR THE TREATMENT OF BLOOD DISORDERS

The present intervention generally relates to compositions comprising S-isomer of alpha-methyl- hydrocinnamic acid for the treatment and/or prevention of blood disorders and blood deficiencies, as wel..

SMALL MOLECULE INHIBITORS OF HEPATITIS C VIRUS

The invention provides derivatives and analogues of triazatetracyclo[7.7.0.01,13,.02,7]-hexadeca-2,4,6,10,12-pentaenes, 5,7,11-triazatetracyclo[8.7.0.01,6.012,17] -heptadeca- 6,8,12,14,16-pentaenes, p..

GLUTAMINE ENDOPEPTIDASES D'ESPÈCE ROTHIA ET UTILISATION DE CELLES-CI

Disclosed are glutamine endopeptidase enzymes from Rothia sp. bacteria that are naturally associated with the oral cavity, formulations comprising the glutamine endopeptidase enzymes and the use there..

METHODS FOR TREATING VIRAL DISORDERS

Disclosed are methods of treating viral disorders via the administration of an inducing agent and an anti-viral agent. In one embodiment, the inducing agent and the anti-viral agent are administered f..

Compositions for the treatment of blood disorders

The invention relates to compositions containing chemical compounds and compositions containing steel factor which stimulate the expression of hemoglobin or globin protein such as embryonic or fetal g..

LIPOXIN ANALOGS AND METHODS FOR THE TREATMENT OF PERIODONTAL DISEASE

This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis,..

CIRCULATING MIRNAS AS NON-INVASIVE MARKERS FOR DIAGNOSIS AND STAGING IN PROSTATE CANCER

The present invention relates to a method for staging prostate cancer in a subject suffering from prostate cancer, said method comprises (a) determining the amount of at least one miRNA selected from ..

HUMAN ANTIBODIES AGAINST HEPATITIS C VIRUS (HCV) USES THEREOF.

Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma..

SPINAL MUSCULAR ATROPHY (SMA) TREATMENT VIA TARGETING OF SMN2 SPLICE SITE INHIBITORY SEQUENCES

The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence element, named ISS-N1 (for "intronic splicing..

NOVEL METASTASIS SUPPRESOR GENES AND USES THEREOF

The invention relates to methods for detecting a metastatic cancer, methods for inhibiting tumor metastatic properties, methods for treating tumor metastasis, methods for identifying agents for the tr..

LIPID-AMINO ACID CONJUGATES AND METHODS OF USE

N-fatty acid-amino acid conjugates and J2 prostanoid-amino acid conjugates are disclosed along with methods for making such conjugates and methods of using these conjugates in the treatment of conditi..

METHODS FOR TREATING ENDOPLASMIC RETICULUM (ER) STRESS DISORDERS

The present invention provides methods for treating ER stress disorders and for identifying compounds for treating ER stress disorders.

TYPE III SECRETION INHIBITORS, ANALOGS AND USES THEREOF

The invention, in some aspects, relates to compounds and compositions useful for inhibiting Type III secretion systems in pathogenic bacteria, such as Yersinia Pestis. In some aspects, the invention r..

HUMAN ANTIBODIES AGAINST RABIES AND USES THEREOF

Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating ..

Methods and Compositions for the Treatment of Sterile Inflammation

Described are methods and compositions that inhibit IL-1 signalling for the treatment of acute inflammatory response to cell necrosis, and the attendant collateral tissue damage.

METHODS OF MONITORING TREATMENT OF AVIREMIC HIV-INFECTED PATIENTS

Methods of monitoring the efficacy of intensified highly active anti-retroviral therapy (HAART) treatment in aviremic Human Immunodeficiency Virus (HIV)-infected patients.

METHODS FOR IDENTIFYING MODULATORS OF THE PP2A B56 BETA REGULATORY SUBUNIT

The present invention is based at least in part on the discovery that the PP2A B56 beta regulatory subunit plays a role in regulating insulin signaling by directly regulating phosphorylation of AKT-I...

METHODS AND COMPOSITIONS FOR REDUCING INFLAMMATION AND TREATING INFLAMMATORY DISORDERS

Methods of treating an inflammatory disorder and inhibiting inflammation by administering an inhibitor of a pH-activated protease are provided.

COMPOUNDS FOR MODULATING RNA BINDING PROTEINS AND USES THEREFOR

The invention relates to compositions and methods for inhibiting RNA binding proteins (e.g., MEX-3, MEX-5 and POS-1), as well as methods for treating and preventing disorders associated with parasitic..

METHODS AND COMPOSITIONS FOR TREATING NEUROLOGICAL DISEASE

This invention relates to methods and compositions for treating neurological disease, and more particularly to methods of delivering iRNA agents to neural cells for the treatment of neurological disea..

COMPOUNDS FOR MODULATING TLR2

The present invention is directed to methods, kits, and uses of inhibitors of LCMV mediated NF-?B activation to treat viral infections and inflammatory conditions.

METHODS FOR TREATING GLIOBLASTOMA

Described are methods for treating cancers, e.g., glioblastoma, including administering an inhibitor of Notch signalling, e.g., a gamma secretase inhibitor, in combination with a chemotherapeutic agen..

TUMOUR-SPECIFIC P450 PROTEIN

The discovery that CYP1B1 protein is detectable in a wide range of human cancers of different histogenetic types, but is not detectable in non-cancerous tissues, gives rise to diagnostic methods for d..

DETECTION OF HUMAN IMMUNODEFICIENCY VIRUS CO-RECEPTOR TROPISM IN AVIREMIC SUBJECTS

Methods for detecting human immunodeficiency virus (HIV) co-receptor tropism or replication-competent virus in aviremic subjects, and methods of selecting optimal therapies for aviremic subjects.

METHODS FOR THE TREATMENT OR PREVENTION OF DIABETES MELLITUS AND OTHER METABOLIC IMBALANCES

The invention relates to methods for treatment and prevention of a metabolic imbalance, including diabetes mellitus and other related diseases or disorders, using an extract from a fruit of genus Elae..

IRF AS A TUMOR SUPPRESSOR AND USES THEREOF

The invention relates to methods for treating BCR/ ABL mediated disorders. The methods of the invention also include monitoring progression of or sensitivity to treatment of BCR/ ABL mediated disorder..

MICRONA COMPOSITIONS IN THE TREATMENT OF VEGF-MEDIATED DISORDERS

The invention provides methods of treating diseases caused by the over-production of a VEGF polypeptide by administering miRNA or miRNA inhibitor compositions to decrease at least one activity of a VE..

A METHOD FOR PREVENTING OR ALLEVIATING THE NOXIOUS EFFECTS RESULTING FROM TOXICANT EXPOSURE

The present invention provides a method of using agents which can modulate TRPAl function as counteragents to inhibit the physical effects of chemical irritants/toxicants when given prior to exposure ..

CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS

The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compo..

TREATMENT AND PREVENTION OF WHITE MATTER INJURY WITH KATP CHANNEL ACTIVATORS

The present invention includes a method of treating or preventing a CNS white matter injury in a patient in need thereof. The invention also includes a method of stimulating proliferation of a CNS cel..

COMPOUNDS AND METHODS FOR TREATING VIRAL ENCEPHALITIS

The invention includes compositions, methods, and techniques for influencing or otherwise altering or regulating signaling that emanates from ligands, receptors, or pathways of TLR7, and/or IL- 12, an..

METHODS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF PREECLAMPSIA

Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.

ACTIVATED WNT-BETA-CATENIN SIGNALING IN MELANOMA

The present invention is directed to a method of determining the prospects for survival of a melanoma patient. This method involves providing a biological sample from a patient diagnosed with melanoma..

MODULATION OF SIRT1 EXPRESSION

Methods are provided for reducing SIRT1 expression by administering a SIRT1 inhibitor. Also provided are methods for treating cardiovascular and metabolic disorders in a subject or delaying or prevent..

Apoptosis-Based Evaluation Of Chemosensitivity In Cancer Patients

Induction of apoptosis in target cells is a key mechanism by which chemotherapy induces cell killing. An in vitro system has been established for determining carboplatin and paclitaxel (Taxol) chemose..

Method and composition for treating immune complex associated disorders

The present invention provides methods and compositions for treating immune complex associated diseases (ICAD), such as SLE, rheumatoid arthritis, and hepatitis-C related immune complex disease (e.g.,..

C/CLP Antagonists And Methods Of Use Thereof

The invention relates to the novel discovery that antagonizing a C/CLP can be useful for the treatment of diseases associated with the upregulation of one or more C/CLP such as Th2-driven and/or IL-13..

METHODS OF TREATING HEPATITIS

The present invention relates to a method of treating hepatitis in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient.

Diagnosis and Treatment of Age Related Macular Degeneration

Methods, compositions and kits for diagnosis and treatment of age related macular degeneration.

Method for suppressing immune system response to transplanted tissue or cells

Methods are provided for suppressing the immune system response in recipients of transplanted organs, tissues or cells. An extracorporeal quantity of blood from the intended transplant recipient is tr..

COMPOSITIONS AND METHODS FOR TREATING OR INHIBITING LIVER INJURY

The present invention relates to the discovery that acetylsalicylic acid (ASA or aspirin), salicylic acid (SA) and related salicylate esters and their pharmaceutically acceptable salts, when coadminis..

HERBAL COMPOSITION PHY906 AND ITS USE IN CHEMOTHERAPHY

This invention provides herbal compositions useful for increasing the therapeutic index of drugs, including those used in the treatment of disease, especially viral infections and neoplasms of cancer...

AN OBJECTIVE, QUANTITATIVE METHOD TO PREDICT HISTOLOGICAL SUBTYPE IN NON-SMALL CELL LUNG CANCER

The invention provides a method for determining the histotype of a non-small cell lung cancer tumor which comprises (a) determining the levels of expression of each of thyroid transcription factor-1 c..

Anti-viral nucleoside analogs and methods for treating viral infections, especially hiv infections

The present invention relates to novel compounds according to the general Formulae (I, II, III, IV or V); wherein B is nucleoside base according to the structure Formula (VI); R is H, F, Cl, Br, I, C ..

Nogo Receptor Binding Small Molecules to Promote Axonal Growth

The present invention provides a method for identifying compounds which modulate the interaction of Nogo and Nogo receptor (NgR). The present invention also provides compounds that modulate the intera..

METHODS FOR MODULATING EXPRESSION OF CREB

Methods are provided for modulating CREB by administering a CREB-specific modulator. Also provided are methods for treating cardiovascular and metabolic disorders in a subject or delaying or preventin..

Survivin, a protein that inhibits cellular apoptosis, and its modulation

The present invention provides the amino acid of a protein that inhibits cellular apoptosis, herein termed the Survivin protein and nucleic acid molecules that encode Survivin. Based on this disclosur..

Neovascular-Targeted Immunoconjugates

Immunoconjugates for treating diseases associated with neovascularization such as cancer, rheumatoid arthritis, the exudative form of macular degeneration, and atherosclerosis are described. The immun..

Reactivation of Axon Growth and Recovery in Chronic Spinal Cord Injury

Disclosed are methods of treating chronic nervous system diseases or injuries, e.g., chronic spinal cord injury, using Nogo receptor antagonists, including Nogo receptor-1 (NgR1) polypeptides, Nogo re..

COMPOSITIONS AND METHODS FOR TREATING CANCER WITH ATTENUATED ONCOLYTIC VIRUSES

Compositions including attenuated oncolytic viruses and methods of their use for the treatment of cancer are disclosed. Some attenuated virus exhibit potential as tumor therapies by exhibiting charact..

AQUEOUS EXTRACT OF PIERIS BRASSICAE LARVAE AND ITS USE AS ANTIOXIDANT

The present research respects to the aqueous extract of Pieris brassicae larvae fed with tronchuda cabbage, which possesses antioxidant activity against radical species prejudicial to health and has c..

HYDROXYAPATITE AND BIOGLASS-BASED PELLETS, PRODUCTION PROCESS AND APPLICATIONS OF THEREOF

The present invention refers to hydroxyapatite and bioglass-based pellets of homogeneous size and spherical shape, whose interconnective porous structure, in the micrometer range, allows for an enhanc..

URINARY GM2 ACTIVATOR PROTEIN AS A MARKER OF ACUTE RENAL FAILURE OR THE RISK OF DEVELOPING ACUTE RENAL FAILURE

The invention relates to a method of determining the risk of developing acute renal failure (ARF) in an individual, or of determining an ARF, and a method of predicting the progression of an ARF, by d..

GLYCOSYLATED INDOLECARBAZOLES, METHOD FOR OBTAINING SAME AND USES THEREOF

Glycosylated indolecarbazoles, method for obtaining same and uses thereof. This invention relates to rebeccamycin and staurosporine derivatives obtained by means of fermentation of recombinant bacteri..

OVIEDOMYCIN DERIVATIVES, METHOD FOR OBTAINING SAME AND USE THEREOF

The invention relates to oviedomycin derivatives, the method for obtaining same and the use thereof. The invention relates to oviedomycin derivatives obtained by fermentation of recombinant bacterial ..

Therapeutic Use of the Encoding Sequence of the Carboxy-Terminal Domain of the Heavy Chain of the Tetanus Toxin

The present invention relates to the therapeutic use of the encoding sequence of the carboxy-terminal domain of the heavy chain of the tetanus toxin and of the polypeptide encoded by said sequence, pr..

USE OF CATECHOLAMINE FOR DIFFERENTIATION OF STEM CELLS INTO CARDIOMYOCYTES

The present invention relates to the use of catecholamine for differentiation of stem cells into cardiomyocytes and their maturation and a method for obtainment and maturation of these cardiac cells. ..

USE OF eNOS INHIBITORS IN NERVOUS REGENERATION

The invention relates to the use of inhibitors of the activity and/or expression of the endothelial isoform of the NO synthase enzyme (eNOS) in the preparation of a medicament for increasing the regen..

USE OF MASLINIC ACID FOR TREATING NOCICEPTIVE, INFLAMMATORY AND NEUROGENIC PAIN

Use of maslinic acid for treating nociceptive, inflammatory and neurogenic pain. The present invention relates to the use of maslinic acid and any of the derivatives thereof for treating painful patho..

METHOD FOR GENERATING A VIRTUAL SIMULATED PATIENT

The invention relates to a virtual simulated patient (talk bot) simulating the behaviour of a patient during a medical consultation such that the responses are as realistic as possible, corresponding ..

USE OF MASLINIC ACID FOR THE TREATMENT OF DISEASES AND THE SYMPTOMS THEREOF BY MEANS OF COX-2 INHIBITION

The invention relates to the use of maslinic acid or natural, synthetic or semi-synthetic maslinic-rich mixtures or of a composition containing said acid for the treatment of pathological processes as..

USE OF VIRGIN OLIVE OIL POLYPHENOLIC COMPOUNDS IN CANCER TREATMENT

The invention relates to the use of polyphenol compounds present in extra virgin olive oil for the treatment of cancer, as well as to pharmaceutical compositions containing same and to the use thereof..

COMPOSITION FOR PREVENTING OR TREATING MEDICAL DISORDERS ASSOCIATED WITH ANGIOGENESIS AND CELL PROLIFERATION

The invention relates to a composition which includes a statin and an agent activating the vascular endothelium. Said composition can be used for producing drugs or pharmaceutical compositions, prefer..

USE OF THE MASP-52 PROTEIN FOR THE DIAGNOSIS, TREATMENT AND PREVENTION OF CHAGAS DISEASE

The invention relates to the use of the MASP-52 protein, from the mucin-associated surface protein (MASP) family, for the diagnosis, treatment and prevention of Chagas disease, including a method for ..

SYNTHETIC ANALOGUES OF MEROSESQUITERPENES AND RELATED COMPOUNDS HAVING ANTITUMOURAL ACTIVITY

The invention relates to antitumoural properties in respect of solid tumours, such as breast, neuroblastomas, lung, colorectal, hepatic and pancreatic cancers both in humans and in animals, of synthet..

NOVEL (RS)-7- OR 9-(1,2,3,5-TETRAHYDRO-4,1-BENZOXAZEPIN-3-IL)-7H OR 9H-PURINES HAVING ANTITUMOUR ACTIVITY

The invention relates to compounds intended for use in the treatment of human and animal tumours. Experimental results obtained on breast tumour and non-tumour cells lines suggest that the selected co..

AQUEOUS SOLUTION FOR THE PRESERVATION OF TISSUES AND ORGANS

It is provided an improved aqueous solution for the preservation of tissues and organs comprising carvedilol, tacrolimus, and trimetazidine. A synergistic effect is observed for this preservation solu..

METHOD AND KIT FOR PREDICTING THE CHANCES OF SURVIVAL OF PATENTS WITH MANTLE CELL LYMPHOMA

Mantle cell lymphoma (MCL) is a distinct subtype of B-cell non-Hodgkin's lymphoma (NHL-B). The invention provides a method and a kit for predicting the chance of survival of a patient suffering from M..

Protein Product for Treatment of Infectious Diseases and Related Inflammatory Processes

The inventors have found that CD6, a member of the Scavenger Receptor Cysteine-Rich (SRSR) superfamily expressed on human lymphocytes binds to Gram-positive and Gram-negative bacteria, as well as to o..

METHOD FOR THE PREDICTION OF THE SEVERITY OF NUCLEAR ENVELOPE-RELATED DISEASES.

Nuclear envelopathies are diseases caused by a malfunction of nuclear envelope associated proteins or lamins. Nuclear envelopathies are heterogeneous group of diseases, ranging from muscle and lipid d..

METHOD FOR SCREENING COMPOUNDS FOR THE TREATMENT OR PREVENTION OF COLON CANCER

The invention is in the field of molecular medicine, more in particular in the field of identifying new compounds for the treatment or prevention of colorectal cancer. The invention provides a method ..

METHOD FOR THE TREATMENT OF ISCHEMIA REPERFUSION INJURY

The invention is in the field of thrombosis, haemostasis, cardiology, medicinal chemistry and/or pharmacology. More particularly, it relates to the use of a mutant activated protein C (APC) for the tr..

DIAGNOSTIC AND THERAPEUTIC TOOLS FOR DISEASES ALTERING VASCULAR FUNCTION

The invention relates to diagnostic and therapeutic tools and applications, particularly useful in diseases that affect vascular health and in inflammatory diseases. In particular, said diagnostic and..

MEANS AND METHODS FOR DIAGNOSING AND/OR TREATING A SUBJECT AT RISK OF DEVELOPING HEART FAILURE

The present invention relates to a method for identifying a subject at risk of developing heart failure, comprising: (a) determining the level of one or more biological markers in a biological sample ..

TWO COMPONENT BONE CEMENT COMPOSITION FOR VERTEBROPLASTY

The invention is directed to an intrinsically radio-opaque two component bone cement, comprising a first component which contains at least one acrylate monomer and a second component which contains at..

TREATMENTS INVOLVING GLUTAREDOXINS AND SIMILAR AGENTS

The present invention generally relates to treatments involving glutaredoxins. In one aspect, systems and methods of the invention can be used to treat a subject having an oxidative stress condition, ..

Disease susceptibility

The invention provides a method of assessing the susceptibility of a subject to an anxiety disorder or depression, the method comprising determining whether the subject has a haplotype comprising rs32..

ORGAN PROTECTION

The present invention provides compositions, medicaments and methods for use in preventing and/or alleviating the damaging effects of hypoxia and/or reperfusion injury.

SPHINGOSINE- 1- PHOSPHATE (S1P) RECEPTOR COMPOUNDS

The invention relates to compounds, in particular 2-amino- 3, 4, 5, -trisubstituted thiophenes, pharmaceutical compositions containing them and the uses of said compounds and compositions for diseases..

USE LARCH WOOD MATERIAL FOR TREATING INFLAMMATION

The application of wood material from a tree of the genus Larix for treatment and prophylaxis of inflammation in humans or animals is described. The present invention is based on the use of raw larch ..

METHOD FOR DETECTING A WOUND INFECTION

he present invention relates to a method for detecting a wound infection comprising the steps of : - contacting a sample obtained from a wound with at least two substrates for at least two enzymes sel..

TARGETS FOR RETROVIRUS ASSOCIATED DISEASES

The invention generally relates to retrovirus associated diseases, including diseases caused by human immunodeficiency virus (HIV) or human T-cell leukaemia virus (HTLV). In particular, the invention ..

Surgical procedure for the treatment of female urinary incontinence: tension-free inside-out transobturator urethral suspension

A new, quick, simple, efficient, safe, and reproducible surgical technique for the treatment of female urinary incontinence, in which the posterior urethra is suspended using a tape passed through the..

Novel isoform of versican and use in diagnosis and therapy

An isolated and purified nucleic acid molecule having a nucleic acid sequence encoding the V4 isoform of versican, or a fragment thereof of at least 30 nucleotides comprising the exon boundary between..

WATER SOLUBLE CURCUMIN COMPOSITIONS FOR USE IN ANTI-CANCER AND ANTI-INFLAMMATORY THERAPY

The present invention relates to the medical field. In a first aspect the present invention relates to novel water soluble cyclodextrin-curcumin complexes having a pharmacological activity, in particu..

Combined method for the sequential measurement of (1) the enzymatically active fraction and (2) the total amount of an enzyme

The present invention is related to a combined method and kit (or device) for the sequential measurement of the enzymatically active fraction and the total amount of an enzyme [(such as myeloperoxidas..

METHOD FOR GENERATING ISLET BETA CELLS FROM DEDIFFERENTIATED EXOCRINE PANCREATIC CELLS

The present invention relates to an in vitro method for generating insulin-producing beta cells from a population of mammalian cells comprising dedifferentiated exocrine pancreatic cells. The method c..

Generation of pancreatic progenitor cells

The invention relates to in vitro methods for producing pancreatic progenitor cells and cell populations from cells having definitive endoderm germ layer phenotype. The invention further encompasses s..

CARBOXYETHYLATED CYCLODEXTRIN POLYSULFATES USEFUL AS MEDICAMENTS

This invention relates to novel ss-cyclodextrin polysulfate compounds comprising from one to three 2-carboxyethyl substituents, and at least two sulfates groups per glucopyranose unit, which are usefu..

THE USE OF TOPOISOMERASE TYPE I INHIBITORS TO TREAT VIRAL INFECTIONS

The present invention relates to the use of compounds, inducing isgylation to treat viral infections. More specifically, the invention relates to topoisomerase type I inhibitors, such as camptothecin ..

MUCOSAL MEMBRANE RECEPTOR AND USES THEREOF

The invention is based on the identification of aminopeptidase N (APN) as the receptor for F4 fimbriae of enterotoxigenic E. coli (ETEC). Based on the observation that oral administration of F4 fimbri..

SYNEPHRINE DERIVATIVES FOR THE TREATMENT OF CANCER

This invention relates to a group of synephrine derivatives represented by the structural formula (I), a stereoisomer thereof, a solvate thereof, or a salt thereof, for use in the treatment of cancer,..

COMPOUNDS FOR USE IN THERAPY

A compound of formula (I) for use in the treatment of a disease of the immune system; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 ..

VIRAL INACTIVATION PROCESS

The invention relates generally to the field of virology. More particularly, the present invention relates to methods for determining the effect of a viral inactivation procedure on the antigenicity o..

MYCOBACTERIUM MUTANTS FOR VACCINES WITH IMPROVED PROTECTIVE EFFICACY

Tuberculosis (TB) is a major health problem and currently, the only licensed TB vaccine is Mycobacterium bovis Bacille Calmette-Guerin (M. bovis BCG). In the present invention, mutation of mycobacteri..

L-PLASTIN ANTIBODIES AND THEIR USE

The present invention relates to antibodies, especially camelid antibodies, binding to the tandem actin binding domain in L-plastin, but not to the single actin binding domains. It further relates to ..

VITAMIN D3 ANALOGUES FOR THE PREVENTION AND TREATMENT OF BONE DISORDERS

Novel vitamin D analogues are useful for making pharmaceutical compositions for the prevention or treatment of bone disorders such as osteoporosis

METHOD FOR ALLEVIATING INTESTINAL PROBLEMS AND NOVEL BACTERIAL STRAINS THEREFOR

The present invention relates to butyrate producing bacterial strains related to the species Buty?coccus pullicaecorum to be used in the prevention and/or treatment of intestinal health problems. The ..

BLOOD SERUM MARKER FOR DETECTION AND DIAGNOSIS OF ALZHEIMER'S DISEASE

The present invention relates to a blood marker for early detection and diagnosis of Alzheimer's disease. More specifically, it relates to an analysis of the protein glycan profile in the blood, and t..

USE OF SIP1 AS DETERMINANT OF BREAST CANCER STEMNESS

The present invention relates to the diagnosis and treatment of cancer. More specifically, it relates to the use of SIP1 nucleic acid and/or protein for the detection of breast cancer stem cells, and ..

INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF

The present invention relates to inhibitors of MALT1 proteolytic and/or autoproteolytic activity. More specifically, it relates to compounds such as, but not limited to peptide derivates such as Z-LSS..

Inhibition of alpha synuclein toxicity

Present inventions demonstrates that alpha synculein toxicity such as [alpha]-synuclein mediated cell death, alpha synuclein induced reactive oxygen species (ROS) in a cell requires the proapoptotic e..

METHODS AND PREPARATIONS FOR PROTECTING CRITICALLY ILL PATIENTS

The present invention relates to the use of a polyamine or a salt, solvate, or derivative thereof, such as spermine or spermidine for the treatment or prevention of a life threatening condition, such ..

NOVEL INHIBITORS OF FLAVIVIRUS REPLICATION

The present invention relates to a series of novel compounds, methods to prevent or treat viral infections by using the novel compounds, processes for preparation of the compounds, their use to treat ..

INHIBITORS OF LENTIVIRAL REPLICATION

The present invention provides peptides having lentiviral replication inhibiting properties, more in particular having antiviral activities with respect to HIV (Human Immunodeficiency Virus). The inve..

BACE1 INHIBITORY ANTIBODIES

The present invention relates to antibodies with a specificity for BACE1. More specifically, the invention provides monoclonal antibodies which bind to BACE1 and are capable of inhibiting the activity..

THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS

The present invention relates to a series of compounds of formula (A) having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention a..

TARGETED RADIOTHERAPY

The present invention concerns a therapeutically labeled napthodianthrone or phenanthro[1,10,9,8-opqra]perylene-7,14-dione compound, which comprises a chemical element or an isotope that has an unstab..

NOVEL VIRAL REPLICATION INHIBITORS

The present invention relates to a series of novel compounds having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relat..

ANTI-CANCER COMBINATION THERAPY

The present invention relates to a combination of therapeutic agents comprising: (a) a cytosine-based anti-cancer drug and/or a purine-based anticancer drug and (b) a therapeutic agent selected from t..

NEAR FULL-GENOME ASSAY OF HCV DRUG RESISTANCE

The invention relates to assays for characterization of genotypic mutations of Hepatitis C Virus (HCV) showing a resistance to anti-HCV drugs.

INHIBITION OF TUMOUR GROWTH AND METASTASES

The instant invention relates to compounds of formula 1 and their applications as an anti-cancer agent and/or as an angiogenesis inhibitor in mammals, preferably in humans; the instant invention also ..

NOVEL ANTIVIRAL AGENT

The present invention relates the use of a composition including or consisting of at least one element selected from among: a predetermined protein including or consisting of the amino acid sequence S..

MACROCYCLIC PRODRUG COMPOUNDS USEFUL AS THERAPEUTICS

The present invention includes macrocyclic prodrug compounds, pharmaceutical compositions containing them. The present invention also includes use of these compounds in the treatment of various diseas..

ANTI-AGING COMPOSITIONS COMPRISING MENYANTHES TRIFOLIATA LEAF EXTRACTS AND METHODS OF USE THEREOF

An anti-aging composition comprising a skin-beneficial amount of actives identified in Menyanthes trifoliata leaf, wherein the actives are inhibitors of one or more of MMP-1, 2 and 9 and/or scavengers..

CALCIUM/SODIUM SALT OF INOSITOL TRIPYROPHOSPHATE AS AN ALLOSTERIC EFFECTOR OF HEMOGLOBIN

The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of..

IRREVERSIBLE INHIBITORS USEFUL FOR THE TREATMENT OF KINASE-RELATED PATHOLOGIES

The present invention provides new compounds (I) having a kinase inhibitory activity and useful for treating cancer.

SYNTHESIS OF RESORCYLIC ACID LACTONES USEFUL AS THERAPEUTIC AGENTS.

Disclosed are macrocyclic compounds of formulae I, I', II, II', III, III', IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, ..

METHOD OF REDUCING MULTI-DRUG RESISTANCE USING INOSITOL TRIPYROPHOSPHATE

Inositol trisphosphate (ITPP) causes normalization of tumor vasculature and is a particularly effective cancer therapy when a second chemotherapeutic agent is administered following partial vasculariz..

METHODS AND COMPOSITIONS FOR TREATING CANCER

The present invention relates to uses or methods for treating proliferative diseases, in particular cancer, implementing ruthenium compounds, as well as to compositions containing same.

CALCIUM/SODIUM SALT OF INOSITOL TRIPYROPHOSPHATE AS AN ALLOSTERIC EFFECTOR OF HEMOGLOBIN

HYDROXY-BISPHOSPHONIC ACID DERIVATIVES AS VECTOR FOR TARGETING BONE TISSUE

The present invention relates to hydroxy-bisphosphonic acid derivatives corresponding to general formula (I): in which: - n and m denote, independently of one another, an integer ranging from 1 to 4, ..

Modified phosphocalcic compound, injectable composition containing same

A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic c..

INJECTABLE CALCIUM-PHOSPHATE CEMENT RELEASING A BONE RESORPTION INHIBITOR

The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhib..

MACROPOROUS AND HIGHLY RESORBABLE APATITIC CALCIUM-PHOSPHATE CEMENT

The present invention is directed to a novel cement powder comprising an organic component consisting of one or more biocompatible and bioresorbable polymers and an inorganic component consisting of o..

TREATMENT OF TUMOURS USING T LYMPHOCYTE PREPARATIONS

The invention relates to the treatment of a tumour in a patient, by injecting T lymphocytes depleted of regulatory T lymphocytes, and expressing a molecule enabling the specific destruction thereof, w..

METHOD FOR OPTIMIZING BLOOD CELL TRANSPLANTS

The invention relates to the use of allogenic T lymphocytes for the preparation of a composition intended to be injected into a recipient patient as conditioning for a hematopoietic stem cell transpla..

TUMOUR-CELL-FIXING CELLS

The present invention relates to an isolated cell capable of fixing tumour cells, expressing the CD10 protein and expressing at least one MDR protein, and to the use of this cell for screening for ant..

USE OF INTERFERING RNA FOR TREATING AN HIV INFECTION

The present invention relates to interfering RNA, in particular miRNAs capable of specifically blocking the replication of an HIV virus strain resistant to an antiretroviral compound, and to the use t..

COMPOUNDS FOR PREVENTING AND TREATING PLASMODIUM INFECTIONS

The present invention relates to the use of at least one compound of formula (I) for the manufacture of a medicament intended for preventing or treating infections by a Plasmodium parasite in an indiv..

TREATMENT OF MOOD AND ANXIETY DISORDERS

The invention relates to a selective inhibitor of EIk-1 or MSK-1 activation for use in the prevention and/or treatment of mood and anxiety disorders.

TYROSINE KINASE RECEPTOR TYRO3 AS A THERAPEUTIC TARGET IN THE TREATMENT OF CANCER

The present invention concerns new methods for treating cancer by using TYRO3 inhibitors and methods for identifying new molecules of interest for treating cancer.

BONE SUBSTITUTE, AND METHOD FOR THE PREPARATION THEREOF

The invention relates to a material that can be used as a bone substitute and to a method for the preparation thereof. The material comprises an organic phase (I) comprising striated collagen fibrils ..

TREATMENT OF RETINAL DEGENERATION

The use of a compound having a gon-4-ene nucleus, said nucleus having attached thereto, in the 13 position, a polycarbon-alkyl radical having 2 to about 16 carbon atoms, said compound containing at le..

A METHOD FOR THE TREATMENT OF CANCER

The invention is based on the surprising finding that treatment with a chemotherapeutic agent such as 5-fluorouracil (5-FU) and an autophagy inducer effectively inhibit the continued growth of, and pr..

A BONE CEMENT

A bone cement comprises a zinc-based glass and polyalkenoate acid. In addition, the cement comprises a controlled amount of tri-sodium citrate (Na3C6HsO7) ("TSC"). The cement has enhanced rheology wit..

COMPOSITION AND METHOD FOR TREATMENT OF PRETERM LABOR

The invention provides a method for treating or preventing preterm labor in pregnant female subjects. The method comprises the step of administering a therapeutically effective amount of a Toll-like R..

TREATMENT OF INFECTIONS

The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in the treatment of microbial infections, p..

COMPOUNDS AND METHODS FOR THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASE

The present invention provides a method and composition for the treatment and prevention of an autoimmune disease such a multiple sclerosis which is mediated by autoreactive T cells. The administratio..

TARGETING PRODRUGS AND COMPOSITIONS FOR THE TREATMENT OF GASTROINTESTINAL DISEASES

Provided herein are compounds, compositions and methods for preventing or treating gastrointestinal cancer in a mammal, wherein the method comprises delivering an effective amount of a COX-2 or a simi..

COMPOSITIONS AND METHODS FOR MODULATING TOLL-LIKE RECEPTOR ACTIVITY

The present invention relates to compositions and methods for use in the treatment of conditions such as septicaemia and septic shock. The invention further provides compositions and methods for the s..

TREATMENT OF MICROBIAL INFECTIONS

METHOD AND APPARATUS FOR STIMULATING PELVIC FLOOR MUSCLES

A method of and apparatus for stimulating pelvic floor muscles in a patient comprises applying at least one electrode externally to each side of the patient's body in the region of the pelvis, and ene..

CAUSAL THERAPY OF DISEASES OR CONDITIONS ASSOCIATED WITH CNS OR PNS DEMYELINATION

The invention broadly relates to the use of the Active in the causal treatment of a disease caused by axonal demyelination, in which the Active maintains the integrity of myelination (for example by p..

DETECTION AND TREATMENT OF AN INVASIVE CANCER PHENOTYPE

A method for the inhibition, prevention or treatment of invasive/metastatic cancer in an individual in need thereof, comprises a step of treating the individual with an agent capable of attenuating th..

A METHOD OF ASSESSING CANCER STATUS IN AN INDIVIDUAL

The invention relates to a method of screening patients to identify patients at risk of having a lung squamous cell carcinoma. A sample of serum from the individual is assayed for the abundance of a p..

A METHOD OF PREDICTING RESPONSE TO THALIDOMIDE IN MULTIPLE MYELOMA PATIENTS

A method of predicting response to thalidomide, or thalidomide analogs, in an individual with cancer, especially cancers for which thalidomide has been implicated as a treatment, such as Multiple Myel..

HIV-1 ENVELOPE POLYPEPTIDES FOR HIV VACCINE

Immunogenic HIV-1 envelope polypeptides are provided, wherein specificamino acid residues are mutated to repress immunosuppression in GP41, thereby boosting the immune response against HIV-1. Specific..

NANOPARTICLE-MEDIATED TREATMENT FOR INFLAMMATORY DISEASES

The present invention provides nanoparticles for treatment of inflammatory diseases. The nanoparticles preferably comprise chitosan and a siRNA targeting a mRNA encoding a pro-inflammatory cytokine, s..

METHOD FOR EARLY DETECTION OF CANCER

The present inventors have demonstrated that circulating auto-antibodies to cancer antigens hold promise as specific and sensitive biomarkers for the early detection of cancer. The present invention t..

PDZ DOMAIN MODULATORS

This invention relates to compounds useful as PDZ domain modulators, in particular the PDZ domain of PICK1. In other aspects the invention relates to the use of these compounds in a method for therapy..

METHODS OF TREATING THROMBOEMBOLIC DISORDERS

The field of the invention relates to methods for dissolving a thrombus using inhibitors of platelet contractility. More particularly, the present invention relates to the use of an inhibitor of plate..

COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE

The present invention relates to pharmaceutical compositions for the treatment and/or prophylaxis of disease associated with fibrosis in a vertebrate, said composition comprising at least one activin ..

ECTOPIC PREGNANCY TREATMENT

The invention pertains to methods for treating ectopic pregnancy. More particularly, the present invention relates to methods for treating unruptured ectopic pregnancy using a non-surgical method comp..

A METHOD FOR TREATING OBESITY

A method and pharmaceutical composition for treating a disease or condition associated with elevated hypothalamic T cell protein tyrosine phosphatase (TCPTP) such as obesity, weight gain, type 2 diabe..

STAT3 INHIBITORS FOR THE TREATMENT OF FIBROSIS

A method of medical treatment or prevention of an interstitial lung disease (ILD) in a subject in need thereof, the method including administering a therapeutically effective amount of a signal transd..

ANTISENSE MOLECULES AND METHODS FOR TREATING PATHOLOGIES

An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 59.

METHOD FOR PREVENTING TRANSPORT OF A NEUROTROPIC VIRUS

The present invention relates to viruses, particularly to cellular transport of neurotropic viruses and the viral and cellular proteins involved with cellular transport of neurotropic viruses.

USE OF VITAMIN D RECEPTOR AGONISTS AND PRECURSORS TO TREAT FIBROSIS

This application relates to methods of treating, preventing, and ameliorating fibrosis, such as fibrosis of the liver, kidney, or pancreas. In particular, the application relates to methods of using a..

DETECTION OF ANTI-PARASITIC COMPOUNDS

The invention relates to screening compounds for anti-parasitic activity, especially for activity against parasitic apicomplexans using Chromerida.

TREATMENTS FOR EXCITOTOXICITY AND Ass-MEDIATED TOXICITY AND AGE-ASSOCIATED NEURONAL DYSFUNCTION

The invention relates to compounds for preventing, inhibiting or antagonising fyn from phosphorylating an amino acid residue in a molecule having an amino acid sequence shown in SEQ ID NO: 1. Typicall..

NOVEL METABOLIC DISEASE THERAPY

The invention relates to the prevention and treatment of metabolic abnormalities characterized by abnormal glucose metabolism, including diabetes mellitus and new onset diabetes mellitus through the u..

METHOD OF DETERMINING RESPONSE TO TREATMENT WITH IMMUNOMODULATORY COMPOSITION

The present invention provides a method for accurately determining the likelihood that a subject will respond to treatment with an immunomodulatory composition comprising detecting one or more markers..

TRANSLOCATOR PROTEIN LIGANDS

The present invention relates to compounds and methods for imaging translocator protein (18 kDa) (TSPO) expression in a subject. This invention also relates to compounds and methods for the treatment ..

A METHOD OF DELIVERING FUNCTIONAL AGENTS ACROSS THE BLOOD-BRAIN BARRIER

The present invention provides a method of delivering a functional agent across the blood brain barrier so that the functional agent is delivered into the brain of the subject, the method comprising t..

Method of treatment and Agents useful for same

The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the mono..

TREATMENT OF CHRONIC INFLAMMATORY CONDITIONS

A method for the treatment of a chronic inflammatory condition in a patient which comprises administration to the patient of an agent which blocks or inhibits IL-3 signalling events in the patient.

Antigenic complex for the diagnosis and treatment of porphyromonas gingivalis infection

Disclosed is a purified multimeric complex from P. gingivalis, the complex comprising at least one domain from each of RgpA, Kgp and HagA, and having a molecular weight greater than about 300 kDa. Als..

VIRAL POLYPEPTIDES AND METHODS

The invention is directed to polypeptides and polypeptide fragments from HIV- 1 envelope (Env) proteins following the characterisation of Env structures from environments where HIV isolates expose con..

Pain treatment

The present invention relates generally to a method for the treatment and prophylaxis of pain. In accordance with the present invention, it is proposed that antagonists of GM-CSF are effective in the ..

Osteoarthritis treatment

The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA). In accordance with the present invention, an antagonist of GM-CSF can be effective in t..

TREATMENT OF FIBROSIS

The present invention relates to methods and compositions for treating fibrosis. In one aspect the invention provides the use of an agent capable of increasing the number of stem cells and/or progenit..

TISSUE CULTURE METHOD USING MAGNETICALLY GENERATED MECHANICAL STRESS

PROBLEM TO BE SOLVED: To provide a culturing method of forming connective tissues such as bone, cartilage, ligament and tendon as tissues functioning like mechanical response, and to provide a culturi..

DEVICES AND METHODS FOR DETECTING ss-HAEMATIN AND HAEMOZOIN

In the application, the change in the magnetic state of the haemoglobin caused by the malarial infection is exploited by detecting suitable properties of haemozoin which are dependent on the applicati..

TREATMENT OF INFLAMMATORY DISORDERS

The present disclosure relates to the treatment of inflammatory disorders. In particular, although not exclusively the present disclosure relates to agents which inhibit a Mas related gene (Mrg) recep..

FERTILISATION PROTEIN

The invention relates to methods of treating male infertility comprising administering human PLC? in an amount of between 150 and 450 femtograms per human oocyte.

MONOCLONAL ANTIBODY FOR APP

The invention relates to a novel peptide, polypeptide or monoclonal antibody for use in the treatment of conditions characterised by elevated levels of ss-amyloid (Ass 39-43 amino acid peptide) in a s..

DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE

The invention relates to novel variants that associate with Alzheimer's disease AD and their use in kits as a means for diagnosing AD; and also their use in nucleic acid molecules or cells/cell lines ..

INHIBITOR OF INFLAMMATORY CONDITIONS

The invention relates to Boswellia frereana and particularly an extract of same for treating a range of inflammatory disorder or conditions selected from the group comprising: articular cartilage degr..

Antimicrobial agent and method for the production thereof

Provided are antimicrobial agents produced fromBurkholderiacepaciacomplex (Bcc) bacteria, in particular from bacteria which comprise a clusture of polyketide synthesis genes. Also provided is use of t..

MATERIAL COMPRISING NM23 LINKED TO A SUBSTRATE FOR USE IN TREATING NEURON DISORDERS

Provided are materials for promoting neuron growth, the materials comprising Nm23 protein, or a biologically effective fragment or derivative thereof, linked to a substrate capable of supporting neuro..

METHOD FOR DIAGNOSING AND TREATING MUSCULAR DYSTROPHY

The invention describes a method for identifying an individual exhibiting symptoms of, or having a propensity to develop muscular dystrophy comprising determining the level of expression in a tissue s..

USE OF VAP-1 INHIBITORS FOR TREATING FIBROTIC CONDITIONS

The present invention relates to inhibitors of VAP-1 and their use as medicaments in treating fibrotic conditions. Furthermore, the present invention relates to a method of diagnosing a fibrotic condi..

GLYCOPROTEINS HAVING LIPID MOBILIZING PROPERTIES AND THERAPEUTIC USES THEREOF

The invention provides compositions and methods for ameliorating symptoms associated with hyperglycemia by administering a Zn-a2-glycoprotein or a functional fragment thereof, methods of decreasing pl..

METHODS OF TREATMENT USING MODIFIED PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 MOLECULES

The present invention generally relates to methods of treating bleeding diseases and disorders and to promote wound healing. The methods comprises administering a procoagulant and a modified plasminog..

Compositions and Methods for Perioperative Bladder Instillation

Polyphenol- and especially catechin-containing compositions (e.g., Polyphenon E) are instilled in the bladder of a subject that previously underwent surgical resection or removal of bladder cancer to ..

MUSCARINIC AGONISTS FOR NEUROLOGICAL DISORDERS AND METHODS OF MAKING THE SAME

Muscarinic receptors with agonist activity and methods of making the same are disclosed. The compound have a thiadiazole compound having a having a quinuclidine ring, a tetrahydropyridine ring, an azo..

NA/K-ATPASE EXPRESSION AS AN INDICATOR FOR THE TREATMENT OF CANCER

Methods for regulating the expression of Na/K-ATPase and uses thereof, including uses in the diagnosis/prognosis and treatment of cancer, are disclosed.

SYSTEM FOR CONCURRENT DELIVERY OF THERMOBRACHYTHERAPY IN THE TREATMENT OF CANCERS

A system combines hyperthermia and radiation treatments in a single treatment modality by using a radioactive seed having magnetic properties.

A PEG-ALBUMIN COMPOSITION HAVING AT LEAST ONE PROTECTED THIOL REGION AS A PLATFORM FOR MEDICATIONS

This composition comprises a polyethylene glycol-albumin composition having at least one protected thiol region wherein the composition comprises PEG-AlbCys34 with Cys-34 preserved as a thiol. The alb..

SOLUBLE GUANYLYL CYCLASE A1 AND A-8R PEPTIDE AS DIAGNOSTIC MARKERS OF AND THERAPEUTIC TARGETS FOR PROSTATE CANCER

The present invention provides materials and methods useful to treat various sGCal- expressing cancers. Materials include peptides which interfere with sGCal's pro-survival functions, thereby resultin..

NON-INVASIVE OCULAR ANALYTE SENSING SYSTEM

A noninvasive method and apparatus for determining analyte concentration (e.g., glucose) in a subject that includes measuring light refraction from at least a portion one or more structures. One examp..

PEPTIDE MANIPULATORS OF REGULATORY T CELL ACTIVITY

The invention relates to peptide inhibitors of Treg cells. Peptides according to the invention are derived from the FOXP3 protein and inhibit its interaction with NFAT. Such peptides are effective to ..

ANTI-INFLAMMATORY AND WOUND HEALING EFFECTS OF LYMPHOID THYMOSIN B-4

The invention relates to a method of treating inflammatory conditions in a subject comprising administering to a subject a composition comprising a lymphoid thymosin-beta4 polypeptide or a functional ..

Male Contraceptive

A compound having formula I. R1, R2, R3 and R4 are independently H or lower alkyl. R5 is aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryloxy, heteroaryloxy, cycloalkyloxy, heterocycloalkyloxy, ary..

COMPOSITIONS FOR USE IN CARDIOPLEGIA COMPRISING ESMOLOL AND ADENOSINE

The invention related to a composition for use in cardioplegia, said composition comprising (i) esmolol; and (ii) adenosine, wherein in use the concentration of said esmolol is in the range 0.3-1.5mM,..

ANTITHROMBOTIC COMPOUNDS

A soluble compound for preventing or reducing blood coagulation comprising an antithrombotic agent and a membrane binding element, wherein the antithrombotic agent has a weight of less than about 5,00..

TREATMENT OF CENTRAL NERVOUS SYSTEM DAMAGE

The invention provides a method of promoting neuronal plasticity in the CNS of a mammal, the method comprising administering to the CNS of the mammal an agent that reduces the inhibitory properties of..

DRUG DELIVERY SYSTEM COMPRISING MATRIX METALLOPROTEINASE INHIBITORS

A composition for topical application to a subjects skin comprising a matrix metalloproteinase inhibitor, more particularly an inhibitor selected from the group consisting of : TIMP-I, TIMP-2, TIMP-3,..

ANTIBODIES SPECIFIC FOR MISFOLDED PROTEINS AND METHODS FOR THEIR PRODUCTION

Methods are provided for producing an antibody specific for a target antigen, in particular, antibodies capable of binding to prion proteins. The methods include adding a target antigen stabilising ag..

CARRIER

Carriers are provided for transport of a substance across the blood-brain barrier. The carriers comprise an antibody specific for a target antigen, in particular, antibodies capable of binding to prio..

METHODS AND COMPOSITIONS

A method of inducing relaxation of the cervix of a female mammal, the method comprising administering at least one pharmaceutical agent selected from follicle stimulating hormone or a beta-subunit the..

METHOD AND APPARATUS FOR IDENTIFYING THE VIABILITY OF ISCHEMIC MYOCARDIUM OF A PATIENT

A method for identifying the viability of is chemic myocardium of a patient. The method includes the steps of measuring in real-time the is chemic myocardium of a beating or non-beating heart, and det..

System, software, and method for detection of sleep-disordered breathing using an electrocardiogram

A system to form and store an electrocardiogram (ECG) signal derived from a cardiac electrical signal that includes an apparatus having a pair of the electrodes to connect to a patient to detect the c..

DRY POWDER DRUG DELIVERY FORMULATIONS, METHODS OF USE, AND DEVICES THEREFORE

The present disclosure relates to systems, methods, and formulations for the pulmonary administration of one or more therapeutic agents, in dry powder form, in a single, large dose quantity. These for..

HOLLOW GOLD NANOSPHERES (HAUNSS) AND HAUNSS-LOADED MICROSPHERES USEFUL IN DRUG DELIVERY

A near-infrared mediated drug delivery system comprising a plurality of microspheres made of polymeric material, each sphere containing a plurality of hollow gold nanospheres together with drug produc..

COMBINATIONAL MULTIDOMAIN MESOPOROUS CHIPS AND A METHOD FOR FRACTIONATION, STABILIZATION, AND STORAGE OF BIOMOLECULES

A new fractionation device shows desirable features for exploratory screening and biomarker discovery. The constituent MSCs may be tailored for desired pore sizes and surface properties and for the se..

USE OF RIBOFLAVIN IN THE TREATMENT OF HYPERTENSION.

The invention provides the use of riboflavin in the manufacture of a medicament for the treatment or prophylaxis of elevated blood pressure in a subject homozygous or heterozygous for the MTHFR C677T ..

METHOD OF STRATIFYING BREAST CANCER PATIENTS BASED ON GENE EXPRESSION

The present invention assists in prospectively predicting the metastatic likelihood, and thereby, the likely clinical outcome of breast cancer patients, based on the genotype of the patient, in partic..

METHODS FOR REDUCING MEIOTIC NON-DISJUNCTION

The present invention relates generally to methods for reducing chromosome non-disjunction and aneuploidy during meiosis in mammals by administering to a gamete an effective amount of cdh1, a derivati..

METHODS OF INHIBITING FIBROGENESIS AND TREATING FIBROTIC DISEASE

The present invention relates to the discovery of an epigenetic relay pathway that controls hepatic stellate cell activation and the wound-healing response in fibrogenesis, including fibrogenesis of t..

THE USE OF LIPID EMULSIONS FOR BINDING HEPATITUS C VIRUS

The present invention relates to compositions, methods and apparatus for use in the treatment of Hepatitis C Virus infection. The methods and apparatus are all based upon the use of very low density l..

METHOD OF INHIBITING CLOSTRIDIUM DIFFICILE BY ADMINISTRATION OF ORITAVANCIN

Glycopeptide antibiotics, such as oritavancin, demonstrate significant activity against both a vegetative form of C. difficile and C. difficile spores. Methods for the treatment, prophylaxis and preve..

COMPOSITIONS AND METHODS FOR REDUCING MACROVASCULAR COMPLICATIONS IN DIABETIC PATIENTS

The present invention relates to compositions and methods for reducing or ameliorating macrovascular complications in diabetic patients using C-peptide. The compositions and methods of the present inv..

METHODS AND COMPOSITIONS FOR TREATING LEUKEMIA

A combination of a BCR-ABL inhibitor and a hedgehog pathway inhibitor for the treatment of leukemia.

Medical Instrument For Grasping An Object, In Particular Needle Holder

A medical instrument for grasping an object, in particular a surgical needle holder, including an elongated shaft, two jaw parts arranged at a distal end of the shaft, at least one of the jaw parts be..

Treatment for keratinizing dermatological disorders by reduction in keratin expression

Compounds and a method for screening for a compound to reduce the expression of keratin proteins in keratinizing dermatological disorders are disclosed. Preferably keratin expression is reduced by the..

MODULATION OF RSK

The present invention relates to specific compounds for use in controlling inflammatory cell function and their potential use in modulating an immune response or inflammation. The present invention al..

SIGMA LIGANDS AND IKK / NF - KB INHIBITORS FOR MEDICAL TREATMENT

The present invention relates to agents that act in concert with sigma receptor ligands to enhance their effectiveness in the treatment of cancer and inflammatory disease. It also relates to methods w..

PROTEIN PRODUCT FOR MODIFYING CARDIOVASCULAR HEALTH

A composition for use in the treatment or prophylaxis of conditions mediated by endothelial function in mammals is provided. The composition includes a milk protein hydrolysate generated by treating m..

DIAGNOSIS AND TREATMENT OF CELL PROLIFERATION AND DIFFERENTIATION DISORDERS BASED ON THE FMN2 GENE

The present invention provides methods for diagnosing cell proliferation and/or differentiation disorders, compounds and methods for treating the same and methods for identifying agents potentially us..

TREATMENT OR PROPHYLAXIS OF PROLIFERATIVE CONDITIONS

The disclosure relates to novel compounds for use in the treatment or prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express cytochrome P450..

ANGINA TREATMENT

A xanthine oxidase inhibitor for use in the treatment of angina is described. The angina may be stable angina pectoris and the treatment may be to eliminate, reduce or alleviate one or more symptoms o..

Methods

The invention relates to a method of detecting an altered behaviour in a population of cells, said method comprising determining at least one of the following characteristics of the population of cell..

MANNOSYLATED BUTYROPHILIN TUMOUR MARKERS

This invention relates to the finding that butyrophilins (BTNs) are mannosylated when expressed by cancer cells. Methods and compositions relating to the detection and treatment of cancer cells expres..

FORMULATIONS OF VIABLE CELLS FOR ORAL DELIVERY

This invention relates to solid formulations for the oral delivery of live microbial cells which comprise dried viable cells and small amounts of a bile acid binding agent, for example, an anion excha..

METHODS FOR PREDICTING AUTOIMMUNE DISEASE RISK

The invention relates to means and methods for determining whether a subject is at high or low risk of autoimmune disease progression by determining the CD8 or CD4 cell subtype of the subject. Autoimm..

TREATMENT OF DISEASES RELATED TO HYPERACTIVITY OF THE COMPLEMENT SYSTEM

Raising the level of Factor I above physiological levels can be used to treat diseases in which the underlying pathology is linked to overactivity of the C3b-feedback cycle and the generation and pro-..

MODULATION OF T-CELL MEDIATED IMMUNE RESPONSES

This invention relates to the finding that the binding of SKAPl to RapL plays a role in the LFA-I mediated adhesion of T cells. Methods are provided for the identification of compounds which alter thi..

METHODS FOR TREATING INFLAMMATORY ARTHRITIS

Provided herein are, inter alia, methods of treating subjects suffering from inflammatory arthritis and identifying candidate compounds for treating inflammatory arthritis.

VISUAL PERIMETER MEASUREMENT SYSTEM AND METHOD

In one example of the invention a patient display is provided on which a fixation graphic or video is shown in substantially the centre of the display, and then target graphics or video are shown at d..

TREATMENT OF PRE-TERM NEONATES

This invention relates to the treatment of pre-term neonates with paraoxonase 3 (PON3) or serum amyloid A like protein 3 (SAA3) to reduce or prevent the morbidity and mortality associated with prematu..

COMPOSITION

The present invention relates to a composition for improving stem cell integration. The present invention also relates to a method of improving stem cell integration and kits for improving stem cell i..

NEURAL INTERFACE

This invention relates to the neural interface comprising one or more electrode-coupled microchannels. Each electrode-coupled microchannel comprises a microchannel for accommodating regenerating nerve..

Improved Reprogramming of Mammalian Cells, and Cells Obtained

Expression of reprogramming factors such as Sox2, klf4, c-myc, Nanog, LIN28 and Oct4 followed by culture in a MEK inhibitor and a GSK3 inhibitor reprograms tissue cells. The invention provides new use..

METHODS OF USING ANTI-INFLAMMATORY COMPOUNDS

The invention relates to the use of 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one for preparing a medicament intended to prevent or treat inflammatory disorders.

Treatment of central nervous system damage

SCD Fingerprints

This invention relates to methods of testing, diagnosing, monitoring, prognostically stratifying and classifying disease, disorders and other medical conditions and physiological states through the de..

Processing retinal images using mask data from reference images

Generating output data indicating areas of a retinal image that represent lesions comprises, receiving candidate date associated with a retinal image indicating areas of the image representing candida..

Handling blood or plasma by EM radiation - in wavelength region of 200 to 320 nanometres at radiation intensity of 1 joule to 1 kilo-joule per sq. metre

The blood or plasma is irradiated directly after and/or before the material exchange process (haemo-dialysis or plasmapheresis) without direct contact through the conveying system (1). The inner surfa..

Filter for selective leucocyte removal from blood etc. - has packing material of plant cell walls, not altering concn., function etc. of erythrocytes

Filter for selective elimination of leucocytes from blood, blood preparations or other leucocyte-contg. biological liq. comprises a sieve-like filter base and as column packing an adsorbent made from ..

Polymerase-inhibiting virustatic agent - extracted from root of Cochlospermum angolense as carotenoid, effective against HIV reverse transcriptase, influenza replicase, etc.

The inhibitor contains a compound (I) from the root of Cochlospermum angolense, with appropriate carriers and adjuvants. (I) is a carotinoid drug extract, obtained with water or alcohol from the finel..

Antiprotozoal compsns. - contain root extract of Cochlospermum angolense

Antiportozoal compsns. contain an active ingredient derived from the roots of Cochlospermum angolense. USE/ADVANTAGE - The compsns. are active against a wide range of human- and animal-parasitic proto..

Anthelmintic agent to treat diseases due to worms - contg. carotenoid drug extracted from roots of cochlospermum angolense

Antihelminth agent contains pharmacologically effective doses of the root contents of Cochlospermum angolense and conventional carriers and auxiliaries. Active ingredient is pref. a carotinoid drug ex..

Procedures and cutlery for the digestion of cells and the preservation and extraction of nucleic acids from living cells or tissues

The invention relates to a method for sample fixation, sample preservation, for cell disruption and extraction of nucleic acids in living cells, cell aggregates and tissue samples, and a working set f..

Fluorescent probe comprises two complementary hybridization sequences that are separated by a peptide with a recognition sequence for a target molecule, which also separates a donor chromophore from a

Fluorescent probe comprises two complementary hybridization sequences that are separated by a peptide with a recognition sequence for a target molecule, which also separates a donor chromophore from a..

PODOPHYLLOTOXIN

PROBLEM TO BE SOLVED: To provide a prodrug of podophyllotoxin having sufficiently reduced adverse effects by the administration to a patient. ; SOLUTION: There is provided a compound in which the prod..

Material layer and electro-surgery system for electrosurgical tissue fusion...

The invention relates to a biocompatible material layer for use as an intermediate layer between tissue surfaces to be fused with a fusion of body tissue. The layer of material is such that it causes ..

METHODS FOR PRODUCING HAIR MICROFOLLICLES AND DE NOVO PAPILLAE AND THEIR USE FOR IN VITRO TESTS AND IN VIVO IMPLANTATIONS

The present invention relates to a method for producing hair microfollicles comprising the steps of: a) providing de novopapillae, b) providing other cell populations selected from the group of fibrob..

Combined Use of TGF-Beta Signaling Inhibitor and Antitumor Agent

The combined use of a TGF-beta signaling inhibitor and an antitumor active substance or an imaging agent modified by a drug-encapsulating macromolecular micelle, or the like, is provided. The selectiv..

CONTRAST MEDIUM-CONTAINING ORGANIC-INORGANIC HYBRID PARTICLE

PROBLEM TO BE SOLVED: To provide a carrier for stably delivering an MRI contrast medium to a target site. ; SOLUTION: The organic-inorganic hybrid particle comprises a block copolymer containing an un..

POLYION COMPLEX COMPRISING PHD2 EXPRESSION INHIBITING SUBSTANCE

Disclosed is a safer and more sustainable gene delivery system or the like, which is effective for treatment of ischemic diseases and the like. Specifically disclosed is a pharmaceutical composition w..

POLYMER/METAL COMPLEX COMPOSITE HAVING MRI CONTRAST ABILITY AND MRI CONTRASTING AND/OR ANTITUMOR COMPOSITION USING THE SAME

The present invention provides a polymer-metal complex composite, which comprises a block copolymer capable of serving as a constituent member of a polymeric micelle and a metal complex having MRI con..

Compositions for Cancer Prevention, Treatment, or Amelioration Comprising Papaya Extract

The components of a brew/extract of leaves or other parts of the papaya plant (Carica papaya) or fractionated components thereof are effective in the prevention or treatment of stomach cancer, lung ca..

METHOD OF TREATING MALIGNANT MESOTHELIOMA

The present invention relates to a therapeutic agent for malignant mesothelioma comprising a substance which inhibits binding of CD26 to extracellular matrix such as an siRNA targeting CD26 cDNA or an..

ENDOPLASMIC RETICULUM TARGETING LIPOSOMES

Provided are compositions that include lipid particles, such as liposomes, that can fuse with the ER membrane of a cell. The lipid particles can also deliver a cargo, such as a therapeutic or an imagi..

MATERIAL FOR PREVENTING TISSUE ADHESION AND MATERIAL FOR PREVENTING JOINT CONTRACTURE

The present invention provides a tissue adhesion prevention material preparable at an affected area at the time of surgical procedure by producing a three-dimensional polymeric structure having a flex..

ULTRASONIC PROBE SUPPORTING DEVICE

PROBLEM TO BE SOLVED: To move an ultrasonic probe along a kneecap to obtain ultrasonic echo information for the cartilage of a knee joint. ; SOLUTION: An attaching unit 16 is positioned by an attachin..

KNEE ACOUSTIC MATCHING BOX FOR ULTRASONIC PROBE

PROBLEM TO BE SOLVED: To achieve acoustic matching between the kneecap and an ultrasonic probe when the ultrasonic probe is moved along the kneecap for obtaining ultrasonic echo information for the ca..

IMAGING TECHNIQUE

The present invention relates to a method of characterising tissue function in a subject in need of such characterisation. The method comprises performing an imaging technique, on a voxel defined with..

TISSUE REPAIR SCAFFOLD

A tissue repair scaffold comprising a secondary fibre bundle, the secondary fibre bundle comprising a plurality of primary fibre bundles, each primary fibre bundle comprising a plurality of fibres, wh..

TREATMENTS AND PREVENTION OF HYDROCEPHALUS

The present invention relates to the prevention or treatment of hydrocephalus. In one embodiment, the invention includes the use of one or more bioavailable folate derivatives, or salts thereof, for t..

Laser Imaging System to Assess the Vitality of Pulpal Chamber of Teeth

Brief Description Researchers have developed a laser imaging system that accurately assesses the pulp vitality of a tooth. This system can assess and image the pulp vitality without pain to the pati..

Portable, Foldable Mirror

The present invention relates generally to mirrors and, more specifically, to a portable mirror having a plurality of foldable mirror panels, each hingedly attached to a main mirror panel. A light fix..

Digital Staining for Histopathology

Background 99.9 % of cancer cases are diagnosed and monitored by histopathological assessment of a biopsy sample. The presence, concentration and distribution of biological molecules (such as nuclei..

Mouse Models of Rhinovirus-induced disease

Background Rhinoviruses cause the common cold, hospitalization of infants, pneumonia in the immunosuppressed and the majority of acute exacerbations of asthma and chronic obstructive pulmonary disea..

Bioresponsive Nanoparticle Aggregates

Background Bioresponsive materials offer a promising commercial opportunity and demonstrate great potential in the medical diagnostics and drug delivery sector. Compared with conventional chemistry,..

Finger Fracture Fixation

Fractures of the finger bones are a common pathological issue which could lead to temporary or permanent loss of normal function. Fractures close to the joint lead to further complications, often resu..

Adjustable Knee Ligament Fixator

The need for a technique that allows post-fixation graft re-tensioning after anterior cruciate ligament (ACL) reconstruction is indicated by clinical observations of excessive anterior laxity in the i..

Treatment of Mast Cell Related Disorders

Isis Project No 3566 CRAC channel blockers provide a novel therapeutic strategy for treating allergic rhinitis and nasal polyposis. Marketing Opportunity Allergy is characterised by an inflammato..

Efficient Cell Cryopreservation Media

Isis Project No 4026 Oxford researchers have developed cell cryopreservation media with well-defined, serum free agents for preserving adult stem cells, human and animal primary cells. Marketing O..

Prostate Cancer Treatment

New prostate cancer treatment that targets prostate cancer cells that have an elevated level of homologous recombination (a DNA repair pathway). Marketing Opportunity Most of the currently availa..

Amidobetaine solution for oral care

The patent includes an aqueous composition for oral care use comprising an amidobetaine solution. The solution includes the following five advantages: 1) The process of the present invention gives..

A Novel Therapeutic Strategy for HIV Infection

BACKGROUND: Tat is an HIV regulatory protein that is essential for viral replication and HIV disease progression. It critically regulates HIV transcription and allows the generation of full-length tra..

Human Osteoblastic Cell Line with Stably Knocked-Down Vitamin D Receptor

Vitamin D3 is implicated in a myriad of biological responses, many of them mediated via the vitamin D receptor (“VDR”). Researchers at the University of California have developed a human osteoblas..

Reversible Inhibitors of Cytosine-C5 DNA Methyltransferase

BACKGROUND: In eukaryotes, the methylation state of a gene specifically affects its transcription. Proper function of the methylation enzyme is crucial for viable development and normal cellular activ..

Rapid Antimicrobial Susceptibility Assay

BACKGROUND: The rising incidence of infectious bacterial strains that are resistant to multiple broad-spectrum antibiotics poses serious complications to the treatment of infectious diseases. Absent k..

A device for radiation therapy of rectal cancer

Colorectal cancer patients primarily undergo surgery for treatment followed by chemotherapy. The surgical procedure leads to development of a scar in the region of the body lower to the pelvic diaphra..

Highly Hypoxia Specific Gene Expression System By the Combination of the Erythropoietin Enhancer and the Erythropoietin 3'-Untranslated Region for Ischemic Disease Gene Therapy

Gene therapy with VEGF (vascular endothelial growth factor) is a new potential treatment for ischemic heart disease. Currently, VEGF is the most effective therapeutic gene for neo-vascularization and ..

An Integrated Wireless Neural Interface for Chronic Recording and Stimulation

The envisioned system integrates, wirelessly, a neural electrode array with a signal processor and a RF-communication module. The neural array can talk simultaneously with many individual neurons on..

Cone-Beam Reconstruction Using the Backprojection of Locally Filtered Projections

Technology for X-ray detection in cone-beam geometry is rapidly improving and offers more and more potential for the construction of robust computed tomography systems for high-resolution volume imagi..

Polymeric Compositions and Methods of Making and Using Thereof

Hydrogels are polymeric compositions, i.e. three-dimensional polymer networks that are capable of absorbing large amounts of water, and swell in water or aqueous fluids without dissolving. The wide va..

Drug Delivery System That Targets Bone and Boosts Availability and Solubility of Therapeutic Drugs

In healthy individuals, bone resorption and formation are well balanced, with the bone mass maintained in a steady state. Disturbance of such balance may lead to a number of bone diseases such as ost..

Novel Allele-Specific Primer Design for Quantitative, Sensitive, Allele Frequency Determination

The present invention provides a novel primer design for real-time quantitative allele-specific PCR (AS-PCR), which results in improved sensitivity, specificity and reproducibility of detection. The u..

Metal-based Membranes with Reduced Autofluorescence to Improve Detection and Imaging of Surface Analytes

Increasing the concentration of cells and microorganisms by filtration for solid phase imaging and counting is a rapid, sensitive tool. In addition, filtration is used for purification of genomic DNA ..

Process and Formulation to Improve Viability of Stored Human Cells and Tissue

There are more than 750,000 tissue and body-part transplants conducted annually, according to the American Association of Tissue Banks. There are many applications that utilize skin grafting: reconst..

Drug Delivery System for Macromolecular Treatment of Arthritis and Other Inflammatory Diseases

The technology in this invention is a water-soluble polymeric drug delivery system for the improved treatment of rheumatoid arthritis and other inflammatory diseases. The delivery system consists of ..

A Family of Intracellular Cholesterol Transport Proteins: Potential Drug Targets for Modulation of Cholesterol Homeostasis and Treatment of Coronary Heart Disease and Assay for Activity

This invention provides for a novel therapeutic target for diseases characterized by defects in cellular cholesterol homeostasis. The inventors have identified a member of a family of proteins that ca..

Strategies for Engineering Precise Folding of Proteins, Peptides, and Antibodies

Peptide cyclization is a common strategy to engineer better polypeptide-based therapeutics, or other industrial proteins/peptides. Cyclization and crosslinking are achieved in nature using disulfide b..

Alpha Conotoxin peptides and derivatives as potential therapeutics for nerve hypersensitivity and neuropathic pain

This invention includes alpha-conotoxin peptides isolated from the venom of predatory snails and related synthetic derivatives which antagonize the a9a10 nicotinic acetylcholine receptor, which has be..

Method for Oral Decorporation of Metals

Several new diseases involving heavy metal poisoning and radionuclide exposure have been introduced to mankind due to the emergence of new technologies. In addition, the potential for exposure is exp..

�O Conotoxins, including MrVIB, with potent and long-lasting analgesic effects

This invention relates to peptides derived from cone snail venom, including MrVIA and MrVIB. These peptides block specific sodium channel subtypes which mediate pain signals in dorsal root ganglion ne..

Proton-Conductive Nanoporous Opal Membranes

Well studied perfluorosulfonated ionomers such as Nafion� show decreased proton conductivity and degradation above 100oC, methanol permeation and swelling in methanol and water, which limits fuel ce..

Raman Spectroscopy Apparatus and Method for Continuous Chemical Analysis of Fluid Streams

The present invention provides apparatus and methods for analyzing the chemical composition of fluid streams using Raman spectroscopy. The apparatus includes a laser source for producing light having ..

Steroid Profiling in Ovarian Follicular Fluid, Importance for Diagnosis, Prognosis, and Determining Strategies for Treatment

Very sensitive assays for assaying concentration and profile of steroid biomarkers in small volumes of ovarian follicular fluid have allowed identification of specific steroid profiles which are usefu..

Steroid-Targeted Therapeutics for the Treatment of Cancer

Cancer is the second leading cause of death by disease in the U.S. It is essential to develop anticancer agents that demonstrate good efficacy without causing systemic toxicity. The cytotoxicity of a..

Targeted Nanoparticles Conjugated to Chelators as Imaging Agents and for Improved Targeting in Chelation Therapy

Excessive iron stored in the body is a powerful catalyst for the generation of highly toxic free radicals that can damage all molecular classes found in vivo. The progression of many diseases such as ..

Molecule Enhanced Optical Detection by Laser Action

There are numerous florescent molecules used as tags in both medical and biological research. These tags are very specific to the other molecules or sites to which they attach. When excited, the tags ..

Medicinal Drugs and Health Products from Natural Sources for Treating a Wide Range of Diseases

Areas of rich biodiversity, such as among the tropical forests and coral reefs of the South Pacific, are home to a wide pharmacopoeia of natural molecules which have evolved to regulate the interactio..

Ligation-During-Amplification (LDA) for DNA modification

Polymerase chain reaction has traditionally been used for in vitro modification and amplification of linear DNA. On the other hand, circular closed loop DNA is often the form replicated in host cells..

GST polymorphic allele assay

Cancer is the second largest cause of death in developed countries, accounting for nearly one in five of all deaths. Polymorphisms of glutathione S-transferase (GST) enzymes have been correlated wit..

Vaccine Candidate Genes Directed Against Virulent Group B Streptococcus

Group B Streptococcus algalactiae (GBS) is the most common cause of bacterial infection in human neonates. Type III GBS is responsible for most bacterial meningitis and a large proportion of other inv..

Siah-1 as a Drug Target for Colorectal Cancer Chemotherapeutics

Colorectal cancer is the second-leading cause of cancer death in the U.S. The American Cancer Society estimates that 56,730 people will die from colorectal cancer in 2004. Sporadic colon polyps and ..

Specific Covalent Immobilization of Proteins through Dityrosine Crosslinks: New Chemistry to Improve Protein Arrays

This invention provides a new immobilization chemistry that combines the versatility of specific protein immobilization with the advantages of site-specific covalent crosslinking. Target proteins are ..

Supported Opal Membranes

Membranes with nanopores are important in molecular transport, molecule-surface interactions at the nanoscale, and in separations. This invention relates to suspended opal membranes formed by the self..

Homogenous bioassays and biosensors.

This invention discloses a novel system that involves the use of a short peptide antigen doubly-labeled with fluorescent dye for use in homogenous bioassays and biosensors. Fluorescent energy transfer..

Compositions and Kits for Fluorescence Polarization Assay of Large Molecules

This invention describes a methodology for determination of high molecular weight antigens based on the principles of fluorescence polarization immunoassay (FPI). An improved oligopeptide composition ..

Bioresponsive Polymers Effective in Contraception, Hormone Delivery, and Protection against STDs

Women across the globe face a serious health threat from preventable STD and HIV infections due to the lack of compliance from partners in condom use. Development of a safe and effective method for p..

Novel Approaches for the Treatment of Nephrogenic Diabetes Insipidus (NDI)

This invention discloses a novel set of interactions between the prostaglandin and purine signaling pathways that reveal a new class of drug targets for future NDI therapies. <i>Benefits</i> Nep..

Method of High-Throughput Drug Screening

The development of effective drugs remains a challenging, risky and expensive endeavor. Currently it takes an estimated 7-10 years to develop and market a drug at a cost that exceeds $800 million. In..

Noninvasive Thermal Triggering of Hybrid Hydrogels

It is now well recognized that when systemic chemotherapy is used in the treatment of solid tumors, it is almost impossible to achieve therapeutic levels of drug at the tumor site without damaging hea..

Hydroxy Alkyl Celluloses that Melt at Body Temperature for Food Preparation and Drug Delivery Applications

Cellulose derivatives, owing to their excellent properties and physiological safety, are used widely as thickeners, adhesives, binders and dispersants, water-retention agents, protective colloids, sta..

Novel Genetic Mutations Affecting Intelligence

Decreased mental acuity can stem from multiple sources; i.e., from head trauma, age related diseases, and inherited genetic defects. An estimated 4.5 million Americans have Alzheimer�s disease or so..

Inhibitors of Ubiquitin Isopeptidases as Pharmaceuticals

For a cell, protein degradation is as essential as protein synthesis. One important intracellular mechanism for protein breakdown is the ubiquitin-proteasome pathway, which functions widely in intrac..

Improved Antithrombin III for Circulatory and Cardiovascular Diseases

Blood vessels are lined with heparin-like molecules that serve an anticoagulant function and help to keep blood flowing through the circulatory system. Many artificial vessels and medical devices als..

Circular, Hairpin, Circular/Hairpin, Lariat, and Hairpin-Lariat Hammerhead Ribozymes

Ribozymes are RNA molecules that can catalytically cleave nucleic acids, thereby suppressing expression of unwanted gene products such as disease causing proteins. This technology includes various co..

Erythropoietin as a Tissue Regenerating Cytokine for Acute Renal Failure and Other Kidney Diseases

Acute Renal Failure (ARF), in the context of multi-organ failure and in high risk patients, remains a common, and often fatal (~50% mortality), complication. Preventative measures are only poorly eff..

Assay and Drug Target for Ewing's Sarcoma

Ewing�s sarcoma is a highly aggressive bone or soft tissue-associated tumor of children and young adults. The tumor frequently progresses undetected until it metastasizes, whereupon the mortality o..

Cancer Systems Biology Website

As biological knowledge continues to grow, searching for how physiological systems function and how they relate to a particular disease becomes ever more difficult. In order to improve the efficiency..

Hydrogels Formulated for In situ Gelation Effective for Drug Delivery and Wound Healing

The high water content and soft consistency of hydrogels make them similar to natural living tissue with numerous applications across the medical field. Under certain conditions it is desirable to pre..

In Vivo Use of GST-activated Nitric Oxide Donors to Treat Cancer and the Multidrug Resistance Phenotype

A class of enzymes known as Glutathione-S-Transferases (GSTs) is over expressed in many forms of leukemia and solid tumors. This over expression is a major mechanism whereby malignant cells acquire d..

Biodegradable Elastomers for Medical Use

Polyurethanes are widely used in the medical field due to their wide range of physical properties and biocompatibility. However, they do not have the inherent ability to biodegrade. This invention a..

Mycoplasma Arthritidis Mitogen (MAM) Superantigen: A Unique Immunomodulator

MAM is a superantigen (SAg) produced by M. arthritidis, a bacterial species that causes murine arthritis, toxic shock and dermal necrosis. MAM has very little sequence homology with any other SAg, but..

Selective Inhibitors/Activators of PDE3 for Treatment of Heart Failure and Vascular Disease

Nonselective cyclic nucleotide phosphodiesterase (PDE3) hydrolyzes cAMP and regulate its content in cardiac myocytes. PDE3 inhibitors are already used clinically in the treatment of heart failure and..

Feedback Dose Control in Thermal Therapy

The American Cancer Society predicted that 1.372 million Americans would be diagnosed with cancer in 2005 and 570,280 would die of it. Improved treatment is imperative for reducing this staggering de..

Quercetin: A Natural Supplement for Treating and Preventing High Blood Pressure (Hypertension)

This invention defines a nutritional supplement formulation containing an effective amount of quercetin that is specifically dedicated to ameliorating, delaying and/or treating hypertension. An effec..

Methods and Apparatus for Minimally Invasive Transverse Aortic Banding: a Useful Tool in the Study of Pathophysiology and Treatment of Pressure-Overload Cardiac Hypertrophy

The present invention provides a curved suture applicator to enable a surgeon to efficiently encircle a target tissue such as a blood vessel with a suture or thread, and a minimally invasive ligation ..

A New Target for Allergy and Asthma Treatment

Eosinophils are a tissue dwelling hematopoietic cell type that likely play a role in parasitic immunity and allergic disease, such as asthma. Activated eosinophils secrete toxic basic proteins such as..

Rational Design of Anxiolytic and Anticonvulsant Drugs

The balance between neuronal excitation and inhibition is critical for information processing in the brain. When this balance is disrupted, epilepsy and anxiety disorders may result. This balance de..

Central Medical Image Storage Respository

This invention outlines the establishment of a central digital medical image repository that can be used by multiple institutions within a region or multi-site radiological imaging network. The inve..

Scanning Probe Microscopy Based Diffusion of Dopant and Impurities

It is common to see devices shrink in size with time, especially electronic devices such as computers, cell phones, mobile music players, pagers, calculators etc. There are, however, some important wo..

Computerized Medical Record for Labor, Delivery, Postpartum, & Nursery

This invention, nicknamed OB.exe, comprises a computerized medical record and a database system that actively manages information on normal laboring women and term newborns. The database captures 800..

Method for producing Beta-Carotene on a Large Scale for use in the Medical, Food and Cosmetics Industry

Carotenoids are antioxidant micronutrients reported to protect against the adverse activity of free redicals. Among the carotenoids, Beta-carotene is the most recognized and widely known carotenoid. F..

Image Guided Interstitial Ultrasound Therapy

The Technology The probe’s delivery system includes five independent channels, each capable of producing up to 50W of RF power. An MRI-compatible motor has also been developed to control the..

Mitochondria Penetrating Peptides

The Background Recent advances in the field of mitochondrial medicine have provided researchers with further incite into the unique structural and functional roles of the mitochondria. Conver..

Improved Enzymatic Synthesis of Oligosaccharides

Enzymatic synthesis of oligosaccharides, while a great improvement over chemical methods, remains expensive due to the difficulty in producing the nucleotide diphosphate sugars (NDPG’s: e.g. uridine..

Human Lipase Cell Lines

Human hepatic lipase cell line – Chinese hamster ovary (CHO) cells have been stably transfected with a human hepatic lipase cDNA to overexpress this enzyme in cell culture. CHO-HL-Lec1 – This cell..

ABCA1 Monoclonal Antibodies

ATP-binding cassette subfamily A member 1 (ABCA1) plays a pivotal role in the production high-density lipoprotein (HDL) and is a member of the ATPase cassette superfamily of transporters. ABCA1 mutati..

Retinitis Pigmentosa Animal Models

Retinitis pigmentosa is a human genetic disorder that causes blindness due to death of photoreceptors. Many cases of retinitis pigmentosa are caused by a mutation in the rhodopsin gene, rhodopsin P23H..

LASER TECHNIQUE FOR THE EVALUATION OF EROSION RESISTANCE OF INSULATING MATERIALS

Dry band arcing is a phenomenon encountered due to the prolonged exposure of high voltage insulation to wet/polluted environment and it is the principal factor that is responsible for degrading the in..

IN-TORCH VAPORIZATION (ITV) SAMPLE INTRODUCTION SYSTEM FOR INDUCTIVELY COUPLED PLASMA SPECTROMETERS

The University of Waterloo has developed a revolutionary sample introduction system for ICP spectrometers that provides dramatically more efficient and significantly increased analysis sensitivity of ..

Apparatus and Method for Cell Culture

Typically, cells are cultured in vitro by growing cells in a fluid or gel-like growth media in a sterile container under controlled temperature, pH and perhaps dissolve oxygen. In many stem cell cultu..

ELECTRIC FIELD TREATMENT CHAMBER

The electro-mechanical instability of cell membrane to electrical field is a phenomenon that has been shown to inactivation of micro-organisms in liquid media. This has led to the development of a met..

Patient Initiated Emergency Response System (PIERS)

More than one million Americans will suffer an acute myocardial infarction (AMI) this year. Within the first 60 minutes of chest pain, 250,000 will die. Before reaching any medical attention, a total ..

Polygraph Sensor Simulation and Testing System

Polygraph testing invloves the measurement of four physiological responses: blood volume in the arim; respiration rate and volume in the thoracic and abdominal areas; and skin conductivity. Automated ..

Computer-Controlled Neurological Stimulation System

Implanted electrical stimulation devices have been employed in the management of chronic intractable pain for over twenty years. The most common electrode implantation site has been the dorsal spinal ..

A Microfabricated Array Sensor for the Electrochemical Detection of Biological Molecules

The ability to detect ultra low concentrations of heme and hemoglobin in bodily fluids has great value in clinical and medical diagnostic applications. Clinical screening for many diseases, such as co..

Cortisol Sensor for Soldier Stress and Fatigue Monitoring

The hormone cortisol, which is produced by the adrenal gland and is released in the body during stressed or agitated states, has gained widespread attention as the so-called "stress hormone." But this..

Airborne Pathogen Neutralization

So far there is no effective way to disinfect or neutralize airborne pathogens in large volumes of contaminated air in real time to protect citizens against a terrorist attack using biological weapons..

Noninvasive Magnetic Sensing of Human Prostate Tumor

Despite the ability of noninvasive electromagnetic bioimpedance methods to measure low contrast changes in tissue, a perennial problem has been the precise localization of the change. Generally, the i..

ENHANCER OF LUMINOL-MEDIATED CHEMILUMINESCENCE

The NADPH oxidase of phagocytic leukocytes generates superoxide anion, a toxic oxygen radical important to bacteriostatic and paracitocidal inflammatory responses. Ongoing studies of the oxidase, the ..

TH1 VACCINES BASED ON REPLICATION ATTENUATED AVIRULENT URACIL AUXOTROPHS OF AN OBLIGATE INTRACELLULAR APICOMPLEXAN

Toxoplasma gondii is an obligate intracellular parasite capable of infecting most warm-blooded vertebrates and most nucleated cell types. Parasite transmission occurs primarily by oral ingestion of ti..

CD161 LIGAND, PILAR, FOR MODULATING ACTIVIATION AND PROLIFERATION OF T CELLS

CD161 is a C-type lectin receptor initially associated with murine NK cells. Unlike murine lymphocytes, the expression of CD161 in human T cells identifies mostly memory lymphocytes and only a small p..

COMPOUNDS FOR INHIBITING, ARRESTING AND POSSIBLY REVERSING NON-ENZYMATIC GLYCATION IN SKIN

Non-enzymatic glycation and cross-linking (Maillard reaction) are well known processes which accelerate the aging of key biological molecules. For example, non-enzymatic glycation of macromolecules su..

METHODS FOR DETERMINING COLLATERAL ARTERY DEVELOPMENT IN CORONARY ARTERY DISEASE

Coronary artery disease (CAD) is the most common cause of morbidity and mortality in industrialized societies. Collateral arteries function as “natural bypasses” effectively restoring the blood fl..

PROGNOSIS AND TREATMENT OF BREAST CANCER

Spot 14, also known as thyroid hormone-responsive Spot 14 (THRSP) or S14, is a primarily nuclear protein that is abundant in tissues active in long chain fatty acid synthesis, including the lactating ..

compositions and methods for inhibiting sonic hedgehog activity

Lung cancer is the most common cause of cancer in men and women in the United States. Lung cancer can be divided into two distinct classes, non-small cell lung carcinoma (NSCLC) and small cell lung ca..

methods for increasing cardiac MAss and performance

Congestive heart failure (CHF) is a chronic, degenerative condition that impairs the heart's ability to pump blood at normal filling pressures to adequately meet the energy requirements of the body. M..

METHOD FOR DETECTING CARDIAC COLLATERAL FORMATION

Coronary collateral circulation has been recognized as an alternative source of blood supply to an ischemic myocardial area. Collateral artery formation is associated with smaller infarcts, less ventr..

compositions and methods for preventing or treating variola virus infection

Variola virus, the most virulent member of the genus Orthopoxvirus, specifically infects humans and causes smallpox. Although smallpox was eradicated in 1980, it remains a potential agent for bioterro..

TRANSGENIC NON-HUMAN ANIMAL MODEL OF LUNG TUMORIGENESIS

Lung cancer is the leading cause of cancer mortality for men and women in United States. Key molecular changes, especially at early stages of carcinogenesis, represent potential pharmacological target..

methods for diagnosing and treating neuroendocrine cancer

Neuroendocrine cancers generally arise from the neuroendocrine system, a diffuse system in which the nervous system and the hormones of the endocrine glands interact. Neuroendocrine cancers also arise..

Novel Inhibitor of Hedgehog Dependent Tumors

Sonic Hedgehog (Shh) plays a critical role in the development of numerous structures. Overexpression of Shh has also been implicated in a number of common human tumors, including lung and pancreatic c..

A NOVEL CLASS OF MODULATORS OF THE ABC TRANSPORTER FAMILY TO IMPROVE THE OUTCOMES OF TREATMENT FOR CANCER THERAPY, SECRETORY DIARRHEA, AND CYSTIC FIBROSIS

ATP-binding cassette (ABC) transmembrane proteins function to transport small molecules such as drugs across membranes. Dartmouth researchers have identified a protein, which is secreted by the bacter..

CHIMERIC NK RECEPTOR AND METHODS FOR TREATING CANCER

Natural killer cells are innate effector cells serving as a first line of defense against certain viral infections and tumors. Natural killer cells have the ability to recognize and kill a variety of ..

DRUG RESISTANCE AND GENE EXPRESSION IN BIOFILMS

Biofilms are communities of microorganisms attached to a surface. Biofilm formation in clinical settings, particularly on a variety of medical implants (such as catheters) results in antibiotic resis..

METHODS OF PREVENTION AND TREATMENT OF DISEASES CAUSED BY THE FUNGAL PATHOGEN CANDIDA ALBICANS

The yeast Candida albicans is the most common fungal pathogen of humans. Most adult females experience sporadic incidents of vaginitis during the course of their reproductive lives and recurrent dise..

COMPOSITIONS AND METHODS FOR INHIBITING THE SYNTHESIS OR EXPRESSION OF MMP-1 FOR TREATING, PREVENTING, OR MANAGING

Overexpression of MMP-1 is associated with several pathological conditions, including the irreversible degradation of cartilage, tendon, and bone in arthritis and the degradation of collagens I and II..

A NOVEL PHARMACOLOGICAL PATHWAY WHICH DESTABILIZES LYSOSOMES AND TARGETS ONCOGENIC OR OTHER ABERRANT PROTEINS FOR DESTRUCTION

Lysosomes are acidic organelles that contain hydrolytic enzymes (such as proteases) that are required for maintaining normal cellular physiology. Lysosomal enzymes participate in diverse cellular fun..

COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING CANCER VIA MODULATING UBE1L AND/OR ISG15

Individuals with acute promyelocytic leukemia (APL)(FAB M3) express oncogenic promyelocytic leukemia (PML)/retinoic acid receptora (RARa). All-trans-retinoic acid (RA) treatment causes complete remiss..

COMPOSITION AND METHODS FOR ENHANCING AND DETECTING PRION PROTEIN

Prion diseases such as Creutzfeldt Jakob Disease (CJD), bovine spongiform encephalopathy (BSE), chronic wasting disease (CWD), and scrapie are fatal, infectious, neurodegenerative diseases that occur ..

NOVEL IMMUNOTHERAPY FOR OVARIAN CANCER

Dartmouth investigators and their colleagues at the University of Kansas have discovered a novel method for rescuing cytotoxic T lymphocytes from destruction by ovarian carcinoma cells in vitro using ..

USE OF MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) FOR TREATMENT OF NEUROPATHIC PAIN

Chronic pain is a dominant health problem. It is the most common reason to seek a physician's care with nearly 40 million office visits scheduled annually. Pain costs the U.S over $100 billion each ..

Implantable Biotelemetry System for Preterm Labor and Fetal Monitoring (ARC-14280)

Abstract: The Fetal Treatment Center (FTC) at UC San Francisco has developed a revolutionary surgical procedure to treat fetuses suffering from diaphragmatic hernia, a condition in which a hole in th..

Rapid Generation of Pulse Flash Free Radicals to Kill Human Cancer Cells, Recycle Human Urine, and Mineralize Organic Chemicals in Wastewater by Using Metallic Cations and Hydrides

Description This invention relates to use the reactions between cationic metals and hydrides to generate free radicals and undergo subsequent oxidation to destroy organic chemicals and kill human canc..

Human Consumable Essential Oil Highly Toxic to Pest Tephritid Fruit Flies

Description We discovered that an essential oil and its constitutes are very toxic to pest tephritid fruit flies including Ceratitis capitata (Wiedemann) (Mediterranean fly), Bactrocera dorsalis (Hend..

Method And Device For Biochemical Sensing

Description Medical diagnostics using chemical sensing of antibody, antigens, DNA fragments and other biochemicals are addressed using semiconductor sensors and supportive biochemical processes. This ..

Laser/Fiber Optic, Piezoelectric, Scanning Confocal Microscope

Description The design includes piezoelectric bimorph bender elements that scan the aperture in the confocal image plane to create a compact, relatively inexpensive, rugged confocal microscope which c..

Monoclonal Antibody DZ-1 for M. leprae (leprosy bacillus)

Description The DZ-1 monoclonal antibody detects specific antigen for the leprosy bacillus, Mycobacterium leprae. The recognized antigen is Phenolicglycolipid-I (PG-I). The monoclonal antibody reacts ..

Detection and Identification of Enteric Pathogens

Description Two pairs of DNA primers have been designed to be used in the Polymerase Chain Reaction System (PCR) to consecutively detect both Salmonella and Shigella. The method used to detect the bac..

Serotype-Specific Probes and Nucleotide Sequences of Listeria Monocytogenes Cluster IIB (4b-4d-4e)

Description Two genes which are unique to serotype cluster IIB (4b - 4d - 4e) have been characterized for Listeria monocytogenes. Serotype 4b is known to be the primary pathogenic species causing list..

Silkworm/Baculovirus Expression System for Production of MSP1 Malaria Vaccine

Description Malaria is a tropical disease that annually infects 200 million people in developing countries, with an estimated 2 -2.5 million people, mostly children, that die of this disease. Globally..

Optimization of Expression Construct and Purification Protocols for a MSP1.42 Malaria Vaccine

Description The invention consists of two parts which both contribute to an enhanced feasibility of commercial production of this potential malaria vaccine: (1) optimization of the MSP1.42 gene constr..

Baculovirus Produced P. falciparum Vaccine

Description The technology covers the construct consisting of the baculovirus polyhedron promoter, the yeast flg5 leader sequence, and the p42 MSP1 sequence with the transmembrane domain deleted clone..

Taccalonolide Microtubule-Stabilizing Agent

Description This new microtubule-stabilizing agent is an effective cytotoxin against many cancer cells in vitro. Bioassay-directed purification of the crude lipophilic extract yielded a steroid with p..

Method of Visualizing Chromosomes of Somatic Cells that Do Not Divide

Description Examination of mitotic chromosomes is essential for cytogenetic research, in particular for the chromosomal mapping of the genes responsible for some genetic disorders and cancers linked w..

Diagnosis and Treatment of Pre-Term Labor

Description Pre-term birth is a serious medical problem in the U.S. with almost half a million babies born prematurely each year. In spite of all recent medical advancements, the premature birth rate ..

Monoclonal Antibodies against Human Flightless-I Protein

Description The Flightless-I Protein was originally identified in the vinegar fly Drosophila but it is conserved in most multicellular organisms, including humans. Studies have shown that mutations in..

Novel Fluorescent Nanosensor Proteins

Description Two innovative sensor-protein platforms have been developed by UH researchers. These sensors are designed for highly sensitive fluorescence resonance energy transfer (FRET)-based molecular..

A Novel Optical Sensor Configuration

Description A novel optical-fiber sensor configuration has been developed for use in parallel bioreactor arrays and other potential applications. A major advantage of this configuration (as opposed to..

Urine Preservative with Combined Antibacterial and Antioxidant Properties (MSC-22695)

Abstract: The Urine Preservative with Combined Antibacterial and Antioxidant Properties preserves urine analytes at ambient temperatures for extended periods of time. The product does not require ref..

Fiber Optic Device for Sensing the Presence of Gas

Technology Description A fiber-optic device for sensing the presence of a gas in an environment is provided. The device comprises a light source for directing a light beam to a layer system having a f..

Humanized Model for Spontaneous Autoimmune Myocarditis

Description: Myocarditis is a major cause of sudden death in children and young adults and is often a precursor of dilated cardiomyopathy, a common indication for cardiac transplantation. Myocar..

Mouse Obesity Model with Modified Leptin Receptor

Description: The hormone leptin regulates food intake, metabolic rate and endocrine function. Disruption of leptin or its receptor molecule abolishes normal regulatory mechanisms, leading to obe..

Insulin Receptor Substrate Knockout Mice

Description: The IRS proteins are the downstream substrates of the insulin receptor in the early steps of the signal transduction pathways triggered by insulin’s binding to its receptor. Insul..

MCK Cre Mice

Description: This technology is an improvement to the cre-lox system for making targeted gene knockouts in mice. Clinical & Commercial Utility: The available technology feat..

Insulin Receptor Knockout Mice

Description: The Insulin/IGF family of ligands and receptors controls mammalian growth, metabolism and reproduction, and insulin signaling at the insulin receptor is implicated in important sign..

Melanocyte Concentrating Hormone Knockout Mice.

Description: Melanocyte concentrating hormone (MCH) is a cyclic peptide found in fish and mammals. Although involved in regulation of color change in fish, it is localized in the ventral aspect ..

Diagnosing and Treating Retinal Vascular Permeability

Description: Diabetic retinopathy (DR) is the leading cause of vision loss in working adults. Although its incidence and progression can be reduced by intensive glycemic and blood pressure contr..

Markers for Pancreatic Cancer and Cell Growth

Description: Pancreatic cancer has one of the highest mortality rates of any malignancy, and the 5-year-survival rate of patients is 4%. Approximately 28,000 patients with pancreatic cancer are ..

Methods of Diagnosing Cardiovascular Disease

Cardiovascular diseases like atherosclerosis are major causes of mortality and often occur as a complication of diabetes. Vascular dysfunction and atherosclerosis parallel the progression of diabetes ..

Diagnosing and Treating Diabetic Retinopathy

Description: Diabetic retinopathy (DR) is the leading cause of vision loss in working adults. Although its incidence and progression can be reduced by intensive glycemic and blood pressure contr..

Methods of Diagnosing Cardiovascular Disease

Methods of Diagnosing Renal Disease

Description: Diabetic kidney disease, also known as diabetic nephropathy, will develop in 25-40% of individuals with Type 1 diabetes mellitus, often leading to early death. The development of di..

Retinal Imaging System

Description: The invention overcomes certain problems inherent in traditional systems for retinal imaging through pupils that have not undergone pharmacological dilation (mydriasis). This is of..

Predictors of Renal Disease

Description: Diabetic kidney disease, also known as diabetic nephropathy, is an important cause of excess morbidity and premature mortality in individuals with Type 1 diabetes mellitus, 25% to 4..

Type 2 Diabetes Mellitus Gene

Description: Type 2 diabetes mellitus is a highly prevalent metabolic disease characterized by hyperglycemia (high blood sugar) as a result of defective insulin action which manifests as insulin..

Protein Kinase C Monocyte Assay

Description: Recent studies have shown that hyperglycemia induces de novo diacylglycerol synthesis and activates Protein Kinase C (PKC), which leads to many kinds of vascular abnormalities (e.g...

Repeat Polymorphism Gene and Uses Thereof

Description: This invention is based on the finding that there is a link between risk for non-insulin-dependent diabetes mellitus (NIDDM) and frataxin, a gene relating to an ataxia disorder. Thi..

Antigen Associated With Type I Diabetes Mellitus

Description: This invention relates to a protein, designated PM-1, that is expressed in human pancreatic islet cells. Autoantibodies to this protein have been found in serum of some prediabetic ..

Diabetogene RAD

Description: This invention relates to a protein whose expression is correlated with certain diabetes disease states, and may therefore play a key role in the etiology of the disease, or may be ..

Improving Glycemic Control

Description: In differential gene expression studies of human tissue, the inventors have found that expression of genes regulated by the transcription factor SRF (serum response factor) is incre..

ARNT2: A Novel Target for Diabetes

Description: The invention is based on the discovery of new targets not previously known to be linked to diabetes. Microarray analysis of human pancreatic islets from people with Type 2 diabete..

ARNT: A Novel Target for Treatment of Diabetes

Description: The invention is based on the discovery of a new target, not previously known to be linked to diabetes. Microarray analysis of human pancreatic islets from people with Type 2 diabet..

SKN-1 and Oxidative Stress Resistance

Description: The transcription factor SKN-1 specifies formation of the feeding and digestive system during early stages of C. elegans embryogenesis. The inventor and his colleagues have shown th..

Insulin Related Transcription Factor

Description: The invention pertains to the identification and cloning of the gene encoding a previously-unknown beta-cell specific transcription factor controlling insulin gene expression. There..

Methods of Modulating Angiogenesis

Description: The invention is based on the finding that the delta isoform of Protein Kinase C can modulate pathways leading to angiogenesis or cell growth. Specifically, PKC-delta was found to r..

Methods for Identifying Compounds for Treatment of Insulin Resistance

Description: This invention arises from the discovery that aspirin’s effect on insulin metabolism is a result of its action against the IKK-beta kinase pathway. IKK-beta activation causes insu..

Diabetogene RAD

Description: This invention relates to a protein whose expression is correlated with certain diabetes disease states, and may therefore play a key role in the etiology of the disease, or may be ..

Insulin Receptor Substrate Portfolio

This portfolio of issued patents covers several proteins (and the genes encoding them) that are the downstream substrates of the insulin receptor in the early steps of the signal transduction pathways..

Insulin Receptor Substrate Knockout Mice

Description: The IRS proteins are the downstream substrates of the insulin receptor in the early steps of the signal transduction pathways triggered by insulin’s binding to its receptor. Insul..

Treatment of Metabolic Disorders with Salicylates

Description: Inflammation participates in the pathogenesis of insulin resistance, type 2 diabetes and cardiovascular disease, and weight gain and obesity are known to be accompanied by activatio..

Obesity and Body Fat Distribution

Description: Obesity is an epidemic health problem worldwide that impacts on the risk and prognosis of many diseases, including diabetes, cardiovascular disease, hyperlipidemia, and cancer. Howe..

Methods and Compositions for Inducing Brown Adipogenesis

Description: The most common fat cells are white adipose tissue (WAT) cells, which have a thin ring of cytoplasm surrounding a lipid or fat droplet. WAT is found underneath the skin and provides..

Methods and Compositions for Modulating Necdin Function

Description: The most common fat cells are white adipose tissue (WAT) cells, which have a thin ring of cytoplasm surrounding a lipid or fat droplet. WAT is found underneath the skin and provides..

Methods of Diagnosis and Treatment of Metabolic Disorders

Description: The invention is based on the discovery that two proteins within a specific family play key roles in the pathogenesis of metabolic disorders such as Type 2 diabetes and obesity. The..

Methods and Compositions for Modulating Adipocyte Function

Description: The most common fat cells are white adipose tissue (WAT) cells, which have a thin ring of cytoplasm surrounding a lipid or fat droplet. WAT is found underneath the skin and provides..

Regulation of Eating Behavior

Description: Melanin concentrating hormone (MCH) is a cyclic peptide found in fish and mammals. Although involved in regulation of color change in fish, it is localized in the ventral aspect of ..

Mouse Obesity Model with Modified Leptin Receptor

Description: The hormone leptin regulates food intake, metabolic rate and endocrine function. Disruption of leptin or its receptor molecule abolishes normal regulatory mechanisms, leading to obe..

Melanocyte Concentrating Hormone Knockout Mice.

Description: Melanocyte concentrating hormone (MCH) is a cyclic peptide found in fish and mammals. Although involved in regulation of color change in fish, it is localized in the ventral aspect ..

Compositions and Methods for Treating Diabetic Eye Disease

Description: Diabetic retinopathy (DR) is the leading cause of vision loss in working adults. Nearly all patients with type 1 diabetes mellitus and over 60% of those with type 2 diabetes eventu..

Diagnosing and Treating Retinal Vascular Permeability

Description: Diabetic retinopathy (DR) is the leading cause of vision loss in working adults. Although its incidence and progression can be reduced by intensive glycemic and blood pressure contr..

Methods for Treatment of Rheumatoid Arthritis

Description: Rheumatoid arthritis affects approximately 1% of the world’s population, and is a significant cause of morbidity. Current therapies for rheumatoid arthritis are based on suppressi..

Treatment of Cardiovascular Disorders with Salicylates

Description: Inflammation participates in the pathogenesis of insulin resistance, type 2 diabetes and cardiovascular disease, and weight gain and obesity are known to be accompanied by activatio..

Enhancing Stem Cell Mobilization

Description: This invention provides a potentially novel approach to enhancing the efficiency of stem cell mobilization, to improve the effectiveness of stem cell transplantation therapies. Hema..

Diagnosing and Treating Diabetic Retinopathy

Description: Diabetic retinopathy (DR) is the leading cause of vision loss in working adults. Although its incidence and progression can be reduced by intensive glycemic and blood pressure contr..

Methods of Modulating Angiogenesis

Description: The invention is based on the finding that the delta isoform of Protein Kinase C can modulate pathways leading to angiogenesis or cell growth. Specifically, PKC-delta was found to ..

Methods of Modulating Fibrosis

Description: The invention features a novel approach to the modulation of the cellular pathways leading to fibrosis and extracellular matrix deposition. Connective tissue growth factor (CTGF) is..

Treatment of Permeability Failure

Description: Peritoneal dialysis is used to treat patients having renal failure. The dialysis fluid used in such treatment contains very high levels of glucose, in order to cause the osmotic ext..

Diabetogene RAD

Description: This invention relates to a protein whose expression is correlated with certain diabetes disease states, and may therefore play a key role in the etiology of the disease, or may be ..

Humanized Model for Spontaneous Autoimmune Myocarditis

Description: Myocarditis is a major cause of sudden death in children and young adults and is often a precursor of dilated cardiomyopathy, a common indication for cardiac transplantation. Myocar..

Methods of Generating Insulin-Producing Cells

Description: A promising avenue of investigation for treatment of diabetes is that of islet cell transplantation. A variety of strategies are under investigation for the introduction into diabet..

Encapsulated Pancreatic Cell Islet Products

Description: The efficacy of islet cell transplantation as a therapeutic strategy for diabetes has been demonstrated in humans by the Edmonton Protocol, but a number of obstacles remain for wide..

Beta Cell Growth and Differentiation

Description: Significant efforts are currently being directed at the regeneration of functional pancreatic islets from beta-cells, as a possible treatment for Type 1 diabetes. However, the facto..

Methods of Modulating Beta-Cell Growth and Function

Description: The invention is based on the discovery that melanin concentrating hormone (MCH), a naturally-occurring peptide hormone known to be involved in feeding behavior and certain neurolo..

Insulin Related Transcription Factor

Description: The invention pertains to the identification and cloning of the gene encoding a previously-unknown beta-cell specific transcription factor controlling insulin gene expression. There..

Method of Making Pancreatic Islet Cells

Description: A major, very promising avenue of investigation for treatment of diabetes is that of islet cell transplantation. A variety of strategies are under investigation for the introduction..

Immunologically Privileged Cells and Uses Thereof

Description: A major, very promising avenue of investigation for treatment of diabetes is that of islet cell transplantation. A variety of strategies are under investigation for the introduction..

Improving Glycemic Control

Description: In differential gene expression studies of human tissue, the inventors have found that expression of genes regulated by the transcription factor SRF (serum response factor) is incre..

ARNT2: A Novel Target for Diabetes

Description: The invention is based on the discovery of new targets not previously known to be linked to diabetes. Microarray analysis of human pancreatic islets from people with Type 2 diabetes..

Treatment of Metabolic Disorders with Salicylates

Description: Inflammation participates in the pathogenesis of insulin resistance, type 2 diabetes and cardiovascular disease, and weight gain and obesity are known to be accompanied by activatio..

Methods of Diagnosis and Treatment of Metabolic Disorders

Description: The invention is based on the discovery that two proteins within a specific family play key roles in the pathogenesis of metabolic disorders such as Type 2 diabetes and obesity. The..

ARNT: A Novel Target for Treatment of Diabetes

Description: The invention is based on the discovery of a new target, not previously known to be linked to diabetes. Microarray analysis of human pancreatic islets from people with Type 2 diabet..

Methods of Treating or Preventing Autoimmune Conditions

Description: The innate immune system is the first line of host defense against pathogens. Innate immune cells, such as dendritic cells and macrophages, are first activated and subsequently trig..

Type 2 Diabetes Mellitus Gene

Description: Type 2 diabetes mellitus is a highly prevalent metabolic disease characterized by hyperglycemia (high blood sugar) as a result of defective insulin action which manifests as insulin..

Methods for Identifying Compounds for Treatment of Insulin Resistance

Description: This invention arises from the discovery that aspirin’s effect on insulin metabolism is a result of its action against the IKK-beta kinase pathway. IKK-beta activation causes insu..

Antigen Associated With Type I Diabetes Mellitus

This invention relates to a protein, designated PM-1, that is expressed in human pancreatic islet cells. Autoantibodies to this protein have been found in serum of some prediabetic individuals who lat..

Regional Chemotherapy with 4-Hydroperoxycyclophosphamide (Intrathecal Administration)

A method of treating human tumors is provided in which tumors are regionally treated with a cytolytic, pre-activated, bifunctional alkylating agent, namely 4-hydroperoxycyclophosphamide. The treatment..

Establishment of a Human Cerebral CortexCell Line

This invention consists of a continuous, non-malignant, neuronal cell line, the cells of which: a) in the undifferentiated form are essentially free of branched process; b) stain positively for neurof..

MIG2

A new member of the chemokine family of cytokines has been identified. These chemokines are produced by interferon-gamma stimulated monocytes. Both the human (HuMig) and marine (MuMig) genes have been..

Primary Culture of Olfactory Neurons

Abstract (Set) The instant primary cultures of purified olfactory neurons can be stimulated with physiological levels of odorants. The neurons of the cultures express markers characteristic of mature..

Anti-viral Target For Herpes Virus

Abstract (Set) A herpes virus proteinase has been identified and cloned from cytomegalovirus. The substrate for the proteinase, which is an assembly protein precursor, has also been identified. The p..

Chronic Endothelial Cell Culture Under Flow

Abstract (Set) An in vitro method for producing a device coated with adherent cells by utilizing shear stress is provided. The device is useful in vivo such in prostheses such as artificial grafts. ..

Molecular Cloning of Macrophage Nitric Oxide Synthase

We now report the molecular cloning of macrophage NOS. The macrophage enzyme displays 50% sequence identity to the neuronal enzyme. Like Neuronal NOS, macrophage NOS has recognition sites for FAD, FMN..

Karyoplasmic Interaction Selection Strategy

Abstract (Set) Karyoplasmic Interaction Selection Strategy is a system of plasmids that assays protein-protein interactions in mammalian cells on the basis of the 2-hybrid system. Description (Set)..

Use of Retinoic Acid

Proliferation of retinal pigment epithelium following surgery or trauma is prevented by contacting retinal pigment epithelium cells with a therapeutic amount of a retinoic acid receptor (RAR) agonist,..

Recombinationally-targeted cloning in Saccharomyces cerevisiae artificial chromosomes

Homologous recombination techniques are used to produce yeast artificial chromosomes (YAC) containing foreign target DNA by utilizing at least three DNA segments which yield the vector. Preferred embo..

New Uses for Camptothecin Analogs (Shapiro - joint)

Camptothecin compounds are effective inhibitors of hemoflagellate growth and are useful in treating leishmaniasis and trypanosomiasis in livestock, other domestic animals and humans.

Reverse Two Hybrid Systems

Methods for identifying molecular interactions (e.g., protein/protein, protein/DNA, protein/RNA, or RNA/RNA interactions). All of the methods within the invention employ counterselection and at least ..

Glutamate Receptor Antibodies

Sub-unit specific anti-peptide antibodies which have been developed against the predicted amino acid sequences of several rat glutamate receptor CDNAs. Description (Set) Proposed Use (Set) The a..

Method of Inhibiting Parasitic Activity

A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorp..

Heart Simulation Software

The Heart Simulation 1 and Heart Simulation 2 programs provide a computer model of the electrical activity of the heart. More specifically, these programs allow for the simulation of cardiac arrhythmi..

Narp Expression and Regulation in Brain

Abstract (Set) A novel neuronal cell growth factor, neuronal-activity regulated pentraxin or NARP and its encoding cDNA sequence is provided in this invention. Narp induces dendritic neurite outgrowt..

Novel Members of the Human Immunoglobulin Superfamily that Mediate the Entry of Alphaherpesviruses into Cells ( 98025/98018)

The alphaherpesvirus subfamily includes neurotropic viruses such as human HSV-1 and HSV-2 and animal viruses such as porcine pseudorabies virus (PRV) and the bovine herpesvirus BHV-1. Viral entry into..

Chondrogenic and Osteogenic Inducing Molecule ( 98063)

A new family of polypeptides, called amelogenins, with activities similar to the bone morphogenetic protein family to potentiate tissue mineralization in vivo, has been identified and characterized. T..

Localization of Major Peptide Autoepitopes for Nucleosome Specific T Cells of Systemic Lupus Erythematosus (20032/99016)

Investigators at Northwestern University have identified peptides localized to distinct regions of histone proteins that are recognized by autoimmune T-cells in Systemic Lupus Erythematosus (SLE). The..

Surface-Associated Delivery of Genes and Oligonucleotides in vivo (20071(v))

This invention describes a novel system for the controlled, efficient delivery of DNA or oligonucleotide (ON) complexes from a supporting scaffold that could be used in tissue engineering or regenerat..

A New Potent Irreversible Inhibitor of y-Aminobutyric Acid Aminotransferase (21058/23058)

A promising new candidate inhibitor of the enzyme gamma-aminobutyric acid aminotransferase, critical to central nervous system disorders, has been prepared. Therapeutic potential in the treatment of e..

Mammalian Sterol Synthesis as a Target for Chemotherapy Against Bacteria (21061)

Recent discoveries at Northwestern University offer the opportunity to use well characterized drugs, known as statins, for a new much needed use, as antibacterial/antibiotic compounds. Thus, the prese..

Cell Line Overexpressing DNA Methyltransferase

Abstract (Set) Abnormal regional increases in DNA methylation, which have potential for causing gene inactivation and chromosomal instability, are consistently found in immortalized and tumorigenic c..

Floxed GFRalpha-1 Mouse

Abstract (Set) Scientists at JHU have created a mouse that harbors mutations allowing for the conditional inactivation of the GFRalpha-1 protein through the use of Cre mouse lines. Description (Set)..

Floxed Ret Mouse

Abstract (Set) Scientists at JHU have created a mouse that harbors mutations allowing for the conditional inactivation of the Ret protein through the use of Cre mouse lines. Description (Set) Pro..

Biomarkers for Chemo-resistance in Ovarian Cancer

Abstract (Set) Ovarian cancer is the most lethal gynecologic malignancy in the US. Although it is initially very responsive (80%) to cisplatin-based chemotherapy, 75% of patients easily develop cispl..

The Preparation and Application of an Adenovirus Construct To Treat Human Cancers

Abstract (Set) JHU scientists have identified a peptide derived from p55PIK, a PI 3-kinse regulatory subunit, which can effectively block the cell cycle progression of a variety of cancers. To delive..

Administration of DNA Vaccines with DNA Encoding Ii-PADRE Generates Potent PADRE-specific CD4+ T-cell Immune Responses and Enhances Vaccine Potency

Abstract (Set) Various strategies have been developed for enhancing DNA vaccine potency by modifying the properties of Antigen Presenting Cells (APCs). These strategies include increasing the number ..

Methods and Compositions for Inhibiting Angiogenesis (21064/21013/20001/96047)

Investigators at Northwestern University have discovered that pigment epithelium derived factor (PEDF), a glycoprotein secreted by a variety of normal cells, is an unusually potent endogenous inhibit..

Reactivation of Mutant p53 with a New Class of Small Molecules (23079)

Novel molecules, effective at inducing apoptosis by reactivating mutant p53, have recently been synthesized by Daniel Appella et. al. These compounds facilitate p53 protein binding to DNA and activate..

Biodegradable, Drug-Releasing Tubes for Tissue Engineering and Regeneration (23091)

Biodegradable drug-releasing conduits for applications in tissue engineering and neuronal regeneration. These conduits are capable of delivering DNA, protein, and/or small molecules. Significance: ..

Cell-specific Molecule and Method for Importing DNA into pulmonary epithelial cell nuclei (24002)

A short DNA sequence that can be placed into any gene therapy vector for efficient targeted expression in pulmonary epithelial cells. This invention has applications in the treatment of a number of p..

Cyclic Peptides and Cyclic Depsipeptides with Antitumor Activity (24095/23053/22081)

A novel family of peptide compounds with enhanced anti-proliferative activity has been synthesized at Northwestern University. These peptide inhibitors have anticancer activity exceeding that of two ..

Modulation of Immune Function by the Targeted Enhancement of CD154 Trimer Stability (25008)

Two lead compounds have been identified that can enhance immune function in vivo through a novel mechanism of stabilizing the CD154 trimer on the surface of activated T cells. ADVANTAGES: The compo..

Arsenic Encapsulation and Triggered Release for Cancer Treatment (25053)

Novel procedures and compositions for the encapsulation and delivery of arsenic drugs. SIGNIFICANCE: Despite its long history and excellent therapy, arsenic compounds have a variety of widely appr..

Protein Kinase Targeted Therapeutics (26087)

A validated novel compound and medicinal chemistry refinement for bioavailable small molecule inhibitors of protein kinases or protein kinase-mediated cellular stress response pathways. ADVANTAGES..

Myosin Light Chain Kinase Inhibitor Compounds, Compositions and Related Methods Of Use (26088)

A new class of small molecule therapeutic candidates with potential to address areas of disease and injury relevant to tissue barrier dysfunction, such as sepsis, lung injury, microvascular leak, Croh..

NOS Inhibitors For Treatment of Motor Deficit Disorder (26093)

Northwestern scientists have prepared compositions that are powerful and highly selective for inhibiting neuronal NOS activity in the fetal brain and protecting fetal rabbit kits from HI-induced sympt..

Improving Islet Survival by Encapsulation in Hydrogels Modified with Anti-Apoptotic Peptides (27055)

Novel in-situ hydrogels enabling islet cell encapsulation, stabilization and protection against cytokine induced cell apoptosis for improved tissue graft survival in transplantation applications. ..

DNA-binding Self-assembling Peptide Amphiphile System for the Transfection of Cellular Aggregates (27116)

A self-assembling peptide system utilizing a bioactive sequence which significantly enhances transfection efficiency. ADVANTAGES: A self-assembling peptide system able to transfect aggregates of c..

Flufenamic Acid for the Treatment of Chronic Pain (27153)

Oral administration of flufenamic acid (FA) has a potent analgesic effect that can be exploited for the treatment of chronic pain. Chronic pain is an invalidating condition affecting a large number o..

Layered Islet Delivery Scaffold (27154, 27090)

Northwestern University has designed a multilayered functional delivery system for islet cell transplantation. The layered polymer advances the opportunity for glycemic control in diabetic patients th..

Administration of DNA Vaccines with DNA Encoding Ii-PADRE Generates Potent PADRE-specific CD4+ T-cell Immune Responses and Enhances Vaccine Potency

DNA-binding Self-assembling Peptide Amphiphile System for the Transfection of Cellular Aggregates (27116)

A self-assembling peptide system utilizing a bioactive sequence which significantly enhances transfection efficiency. ADVANTAGES: A self-assembling peptide system able to transfect aggregates of c..

Control of Human Mesothelin-expressing Tumors By DNA Vaccines

Abstract (Set) Mesothelin has been implicated as a potential ideal target antigen for the development of antigen-specific cancer immunotherapy for the control of mesothelin-expressing cancers such as..

Control of Human Mesothelin-expressing Tumors By DNA Vaccines

Generation and Characterization of a Preventive and Therapeutic HPV DNA Vaccine

Abstract (Set) Cervical cancer is one of the most common cancers in women worldwide. Persistent infection with human papillomavirus (HPV) is considered to be the etiological factor for cervical cance..

Selective, Facile, Quantitative Detection of 2'-deoxyguanosine intermediates

Abstract (Set) A variety of structural modifications (lesions) are produced in DNA when the biopolymer is exposed to oxidative stress. Lesions can be genotoxic and/or cytotoxic, and are useful biomar..

Serial Assessment of Human Tumor Burdens in Mice by the Analysis of Circulating DNA

Abstract (Set) It is generally agreed that internal human xenografts provide the best animal models to study the microenvironments and metastatic processes occurring in human cancers. However, the us..

PIK3CA Exon 9 and Exon 20 Knock in Cells

Abstract (Set) PIK3CA exon 9 and exon 20 knock in cells within the MCF-10A human breast epithelial cell line. Description (Set) Proposed Use (Set) The cell lines described in this invention can..

Estrogen Receptor in Knock out (ERIK) Cells

Abstract (Set) Receptor positive non-tumorigenic human breast epithelial cell line derived from the commercially available MCF-10A human breast epithelial cell line with the p21 gene somatically dele..

K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells

Abstract (Set) Single oncogenic point mutation in codon 12 of K-Ras was "knocked in" to the commercially available MCF-l0A cell line and two other hTERT immortalized human breast epithelial cell line..

Specific Delivery of a Tumor-ablating Agent by a DECApeptide to Colon and Esophageal Cancer Cell Lines as a Therapeutic Treatment

Abstract (Set) Targeted tumor therapy is commonly based on the use of antibodies directed against a specific molecule, and tagged with a tumor ablating material to deliver therapy to the target cell...

Novel Anticancer Drug Leads

Abstract (Set) A novel target for cancer therapy has been discovered by JHU scientists. The drug azalanstat appears to act as an inhibitor and may be used to develop lead compounds for novel angiogen..

A Biotin-labeled Antibody for the Pre-clinical Diagnosis of Alzheimer?s Disease

Abstract (Set) Amyloid beta (A?is the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. Research to determine the dynamic equilibrium of A?n the brain and blood is es..

A Small Molecule Inhibitor of Glioblastomas

Abstract (Set) BACKGROUND: Mutations of the epidermal growth factor receptor (EGFR) are a possible molecular target for cancer therapy. EGFR is frequently amplified in glioblastomas and 30 to 40% of ..

Breast Milk Component Provides Protection Against Acute Respiratory Diseases

Description (Set) It has long been established that breast milk provides a protective role against acute respiratory disease. Scientists at Johns Hopkins University have identified a protective subst..

Automate Image Analyses for Magnetic Resonance Imaging

Abstract (Set) In this disclosure, we describe methods to perform automated analyses of MRI data. We propose automated tissue segmentation and subsequent morphological and photometrical analyses. The..

Variant Gene Increases Risk of Type 2 Diabetes

Description (Set) Type II Diabetes Mellitus (T2DM) represents a major global health challenge with over 170 million people affected worldwide. It is a condition in which the body fails to properly us..

Head & Neck Squamous Cell Carcinoma an Non-Small Cell Lung Cancer Prognostics and Diagnostics

Abstract (Set) Epigenetic changes have been implicated in the pathogenesis of solid tumors and almost all types of cancers primarily via abnormal promoter hypermethylation and silencing of tumor supp..

Seventy Two Gene Model for 8 Thyroid Tumor Types

Description (Set) Thyroid cancer represents 90% of all neuroendocrine malignancies with an estimated annual incidence of 122,800 cases worldwide. Currently, the most useful tool for the diagnosis of ..

Twist overexpression promotes chromosomal instability in the breast cancer cell line MCF-7

Description (Set) Chromosomal instability, the continuous formation of novel chromosome mutations at a rate higher than in normal cells, is a defining characteristic of most human cancers. Twist is a..

Cell Lines with Targeted Deletions of p53

Abstract (Set) Cell lines with deletions of p53 can be used for testing the specificity of drugs that target the p53 pathway. This pathway is inactivated in multiple forms of tumors. The cells lines ..

Targeted Mutagenesis of the Zebrafish Genome Through Manipulation of Helicase Activity

Description (Set) Helicase enzymes are important enzymes functioning in DNA replication, repair, recombination, and RNA transcription. RecQ helicases are a family of helicases that act to suppress ho..

Detection of Prostate Cancer Proteins in Serum for Cancer Diagnosis with a Blood Test

Abstract (Set) There is a crucial need of discovering novel biomarkers to improve the specificity of clinical diagnosis for prostate cancer. To achieve this goal, quantitative proteomic profiling is ..

Processing of Optical Coherence Tomography Signals - for both Medical and Non-Medical Applications (22044)

Optical Coherence Tomography (OCT) is the optical analog of ultrasound tomography. In OCT, an optical wave is launched into a tissue sample where it is reflected off of interfaces and where optica..

Use of Transcranial Magnetic Stimulation (TMS) to Treat Cerebral Palsy.

Description (Set) Cerebral palsy is manifested in a wide range of muscle dysfunctions which can have a severe impact on the quality of life of the patient. Using an innovative imaging technique, JHU ..

Radiolabeled Inhibitors for Prostate Cancer Imaging & Therapeutics

Abstract (Set) Prostate-specific membrane antigen (PSMA) is a cell surface protein that is over expressed in prostate cancer, including hormone-refractory and metastatic disease. Successful imaging o..

Functional Isolation of the Low-oxygenic Niche Derived Primitive Hematopoietic Stem Cells By Differential ROS Activity

Abstract (Set) A low-oxygenic niche in bone marrow limits reactive oxygen species (ROS) production, thus providing long-term protection for hematopoietic stem cells (HSCs) from ROS stress. Although m..

Diagnosis, Prevention and Treatment of Eye Injury and Infection

Abstract (Set) According to the World Health Organization, cataracts are the leading cause of blindness in the world. Approximately 10 million cataract operations are performed each year in the world..

PET32a O-GlcNAcase-thioredoxin Expression Vector

Abstract (Set) Expression and Purification of Recombinant and Endgenous 0- GlcNAcase The human O-GlcNAcase cDNA was subcloned into the commercial expression bacterial expression vector PET32a (Novage..

High-speed Diode for Low-cost Organic Circuitry

Abstract (Set) The Johns Hopkins University seeks a partner to commercialize a new organic diode useful for constructing complex organic electronic circuitry. The diode utilizes polymer and inorganic..

Protein Expression Markers for the Detection of Thyroid Cancer Metastasis

Description (Set) Approximately 80% of all thyroid cancers are papillary thyroid carcinomas (PTCs). Correct staging of PTC is one of the most important parts of the work up of patients for both predi..

MKK4/MAP2K4 KO Lines for Drug Discovery

Description (Set) MKK4 (JNKK1, MAP2K4, and SEK1), a dual-specificity kinase gene on chromosome 17p11, is a tumor suppressor gene that is mutated in a subset of most tumor types. MKK4 protein is activ..

Facile, PCR Free Detection of DNA with Single Nucleotide Discrimination

Abstract (Set) Single nucleotide modifications in DNA have important affects on gene expression. This results in significant phenotypic effects. Mutations in genes can also result in the development ..

Methods To Reduce Damage From Stroke And Other Neurological Disorders.

Description (Set) Cerebral ischemia (stoke) is an acute neurological condition that is caused by a blood clot that blocks a blood vessel in the brain, while a cerebral hemorrhage (stroke) is caused b..

Methods to Block or Reduce Damage from Stroke and Other Neurological Disorders

Description (Set) An acute neurological condition caused by blood clots that block blood vessels in the brain is cerebral ischemia (stroke) similarly; blood vessel breakage in the brain is cerebral h..

A Novel Method for Generating and Screening Peptides and Libraries Displayed on Adenovirus Fiber

Abstract (Set) Capsid-displayed adenoviral peptide libraries have been a significant yet unfeasible goal in biotechnology. Three barriers have made this difficult: the large size of the viral genome,..

A Novel Cystic Fibrosis Therapeutic Agent

Abstract (Set) JHU scientists found that a known drug has a novel function as a stimulator of calcium-activated Cl- channels (CaCCs) and, thus, is a potential therapeutic drug in the treatment of cys..

Candidate Proteasome Inhibitors that Prevent E6 Mediated p53 Degradation and Selectively Kill HPV+ Cervical Cancer

Abstract (Set) High-risk strains of Human papillomavirus (HPV) cause over 90% of cervical cancers. About 20 million people (men and women) are thought to have an active HPV infection at any given tim..

ER alpha M4, ER alpha U4, p16 M4, p16 U5, Hin1 M1, Hin1 U2, RASSF1a M1, RASSF1a U1, RAR beta M1, RAR beta U1, Twist BM2, Twist BU5, APC M3, APC U3, Cylin D2 M1, Cyclin D2 U4, 14-3-3 M2, 14-3-3 U3, HIC

Abstract (Set) Plasmid DNAs incorporating human gene-specific promoter sequences altered by sodium bisulfite treatment. Description (Set) Proposed Use (Set) Their use includes serving as reagent..

Novel Immunotherapy for Contact Dermatitis

Abstract (Set) Allergic contact dermatitis, the third most common reason for outpatient dermatology visits, is an immunological disease that gives significant influences on patient's quality of life ..

Novel Strategy to Induce Erythropoietin Production in vivo

Description (Set) Anemia is the most common disorder of the blood. For chronic anemia such as induced by renal failure and chemotherapy, administration of recombinant erythropoietin (EPO) protein exh..

Mouse Model of Human Head and Neck Squamous Cell Carcinoma

Abstract (Set) Cancers of the head and neck, the majority of which arise in the squamous cells that line the mucosal surfaces in the head and neck, account for 3% of all malignancies in the United St..

PSMA-targeted Nanoparticles for Therapy of Prostate Cancer

Description (Set) Targeted therapy for cancer has gained considerable importance recently with various improvements not only in target identification, but also in small molecule or antibody developme..

Topical Administration of Peripherally Acting Drugs for the Treatment of Chronic Pain

Abstract (Set) Clinicians currently have few therapeutic options when it comes to treating chronic neuropathic pain. Drugs available on the market today are not effective in all patients, and often r..

The Immediate Early Gene Arc Interacts with Endocytic Machinery and Regulates the Trafficking and Function of Presenilin

Abstract (Set) These discoveries promise a novel approach to develop agents to regulate presenilin 1 (PS 1) and treat Alzheimer's Disease and age-dependent memory decline. PS 1 functions as part of t..

A "Molecular Switch" in Group 1 mGluR Signaling Relevant to Neurological and Psychiatric Diseases

Abstract (Set) Reported here is the mechanism by which group 1 metabotropic glutamate receptors (mGluR) are co-functional with dopamine receptors or growth factor receptors. This convergent signaling..

Use of Transcranial Magnetic Stimulation (TMS) to Treat Cerebral Palsy.

Radiolabeled Inhibitors for Prostate Cancer Imaging & Therapeutics

Functional Isolation of the Low-oxygenic Niche Derived Primitive Hematopoietic Stem Cells By Differential ROS Activity

Diagnosis, Prevention and Treatment of Eye Injury and Infection

PET32a O-GlcNAcase-thioredoxin Expression Vector

Protein Expression Markers for the Detection of Thyroid Cancer Metastasis

Regional Chemotherapy with 4-Hydroperoxycyclophosphamide (Intrathecal Administration)

Method of Retarding the Progression of Chronic Renal Failure

Progression of chronic renal failure can be retarded (slowed or arrested) by administering to humans suffering from such disorder an agent which suppresses the production of glucocorticoids in the hum..

BRCA2 KO Lines for Drug Discovery

BRACA2 is a DNA repair gene. Mutations in BRACA2 cause an inherited risk of breast, ovarian and pancreatic cancers. The cancer cell lines are engineered to lack BRACA2 and are useful screening tools f..

Novel Drug Development for Cancer

vivo. Although, the BPU analogs are effective in the palliative management of a wide variety of human malignancies, their utility as chemotherapeutic agents is limited for several reasons: 1) They are..

CanScript For Gene Therapy: A DNA Enhancer Element Conveying Cancer-specific Expression to 30% of Human Malignancies

One of the major requirements for effective cancer gene therapies are DNA sequences that, when inserted into a gene-expression construct, will drive high-level gene expression exclusively in cancer c..

Novel Protein Increases Muscle Mass

Muscle mass is normally regulated by the activities of members of the transforming growth factor-B (TGF-B) superfamily, which act to limit muscle growth. Scientists at JHU have now found a protein th..

Specific Absorption Rate (SAR) Dosimeter for RF Power Deposition in MRI

The present invention addresses the critical need for direct and independent SAR by providing the first dosimeter for MRI which directly measures standard average head and body SAR. The device uses a ..

An Assay to Identify Novel Targets and Personalize Combination Anticancer Therapy

Scientists at JHU have developed a pharmacodiagnostic assay to identify relevant targets and direct the design of individual patient combination anticancer therapy. The assay is based on fine needle a..

Serum Response Factor (SRF) Conditional Knockout Mice

Scientists at JHU have created conditional serum response factor (srf) knockout mice to investigate the plasticity of adult neurons. The mice were generated to circumvent the embryonic lethality assoc..

Myc-repressed microRNAs as Novel Anti-cancer Therapeutic Agents

MicroRNAs (miRNAs) are 18-24 nucleotide RNA molecules that regulate the stability or translational efficiency of target mRNAs. miRNAs are frequently dysregulated in cancer cells and can act as oncogen..

A Novel Agent To Reduce the Requirement of Analgesics in Clinical Pain Management

N-methyl-d-aspartate (NMDA) receptor activation has been demonstrated to play an important role in the processing of spinal nociceptive information. Postsynaptic density protein-95 (PSD-95), a scaffol..

293 Cell Line for Flag-tagged HIMF (flag-HIMF-293)

Hypoxia-induced mitogenic factor (HIMF) is highly up regulated in the lungs as a result of hypoxia-induced pulmonary hypertension, and has proangiogenic and proinflammatory effects in the lung. As a ..

Mutations of the Cholecystokinin Receptor Type 2 in Human Cancers

Gastrin and the cholecystokinin type B/gastrin receptor (CCKBR) have been shown to be expressed in colorectal adenocarcinoma. Colorectal adenocarcinoma is the second leading cause of cancer mortality..

Quantitative Detection of Promoter Hypermethylation as a Biomarker of Acute Kidney Injury During Transplantation

Kidney repair after injury is a recapitulation of normal morphogenesis, with similarities to malignant transformation, and aberrant promoter hypermethylation, also known as epigenetics, is a promising..

Formulation of Toll-like Receptor Ligand with Whole Cell Tumor Vaccine to Enhance Anti-tumor Responses

Established reports in literature have shown that the innate immune system can modulate immune responses against cancer. Lipopolysaccharide (LPS), a Toll-like receptor ligand 4 (TLR4), was absorbed on..

A Functional Assay Distinguishing Pathogenic and Nonpathogenic Variant Alleles of the BRCA2 Gene

Some inherited mutations that inactivate BRCA2 and cause a high familial risk of breast, ovarian, and pancreatic cancer are common in the population. Other mutations are less frequent and referred to ..

Toxic Role of Heme Oxygenase in Hemorrhage

JHU scientists have investigated the contribution of inducible HO-1 to early brain injury produced by intracerebral hemorrhage (ICH). In vivo studies determined that after induction of ICH, HO-1 prot..

Development of a Combinational Paradigm Combating HIV, HIV/HSV or HIV/HPV Infections in Humans

million have been infected in the year 2006 alone. AIDS death reached 2.9 million this year which is the highest ever reported in any year. There are 40,000 new AIDS cases a year in U.S. along. The an..

Biofunctional Fibers

The present invention is directed to surface functionalization of polymeric fibers. Surface biofunctionalization is achieved by covalent conjugation of biofunctional igands and/or cell growth factors ..

Methods for Inducing Immune Tolerance By Inhibiting the Fas Pathway

Fas ligand ("FasL") is a protein with an activity to induce apoptosis of a Fas antigen ("Fas")-expressing cell. Apoptosis of the Fas antigen-expressing cells is believed to be induced by binding of Fa..

Derivation of Multipotent Mesenchymal Cells from Human Embryonic Stem Cells and Biomaterials-Directed In Vivo Commitment

Heterogeneous differentiation of human embryonic stem cells (hESC) limits the potential use of hESCs for cell-based therapies and studies of specific differentiation programs. Clearly, more efficient ..

Persistence Switch Involved in Persister Formation and Tolerance to Multiple Antibiotics and Stresses, as a Drug Target for Persister Bacteria

Persister bacteria are metabolically quiescent cells that neither grow nor die in the presence of antibiotics. The biological mechanism of bacterial persistence is not fully understood but it is clear..

Controlled Microencapsulation of Mammalian Cells

The present invention is directed to an automated device and method to prepare polyelectrolyte microcapsules for controlled microencapsulation of mammalian cells. This device and method delivers preci..

MKK4/MAP2K4 KO Lines for Drug Discovery

Detection of Antibodies to Specific Glycans as a Novel Diagnostic Test for Autoimmune Disease

Abstract (Set) JHU scientists have identified biomarkers specific for autoimmune disease. Systemic autoimmune diseases are life- threatening, complex and can involve various organ systems including s..

Facile, PCR Free Detection of DNA with Single Nucleotide Discrimination

Methods to Block or Reduce Damage from Stroke and Other Neurological Disorders

A Novel Method for Generating and Screening Peptides and Libraries Displayed on Adenovirus Fiber

A Novel Cystic Fibrosis Therapeutic Agent

MicroRNA Expression and Control of Stem Cell Pluripotency, Differentiation and Cellular Processes

MicroRNAs (miRNAs) are a class of short non-coding RNAs that bind to the 3' untranslated region of mRNAs and downregulate their translation to protein. MiRNAs play critical roles in many different ce..

Reversal of Aberrant Cancer Gene Silencing By Inhibition of SIRT1

The class III histone deactylase (HDAC), SIRT1, has cancer relevance because it regulates lifespan in multiple organisms, down-regulates p53 function through deacetylation, and is linked to polycomb g..

Generation of Xenografts on Mice to Tailor Anticancer Therapy from Fine Needle Aspiration Biopsies

Xenografts can be made from resected tumors of pancreatic cancer patients in order to generate tumor tissue for the testing of tailored drug regimes. However, the majority of patients with pancreatic ..

Inhibitors of Human Methionine Aminopeptidase 1 As Novel Anticancer Drug Leads

JHU researchers have unraveled an important function of human type 1 aminopeptidase (hMetAP1) in the timely progression of cells through mitosis. In addition, a new structural class of isoform specifi..

Development of a Biomarker for the Early Detection of Diabetes ("Pre-Diabetes") Based Upon O-GlcNAc

JHU scientists have identified markers in human blood that might readily identify individuals at the early stages of type II diabetes, when life-style changes will be most effective in disease prevent..

Controlled Local Delivery of Glucosamine (GlcN) for Musculoskeletal Repair

The novel feature of this discovery is the application of GlcN to joint and spine (cartilage) tissue engineering/repair. Because of this discovery of the relevant concentrations one can envision new t..

Pkd1 T3041R: Pkd1 Cleavage-deficient Mouse

Scientists at JHU have created a novel mouse model of polycystic kidney disease (PKD), one of the most common human genetic disorders. The mice are deficient in Pdk1 cleavage due to missense mutations..

An Approach to Guide the Individualize Development of New Anticancer Agents

The development of new oncology drugs has not resulted in a meaningful improvement in survival of cancer patients. Major reasons are the lack of criteria, models and guidelines to develop individualiz..

Use of EP3 Receptor Ligands to Reduce Damage from Stroke and Other Neurological Disorders

Cyclooxygenase (COX)-2 inhibitors are well known for their use as anti-inflammatory agents and have also been shown to reduce the damage associated with neuroinflammatory disorders. They act by inhibi..

Use of Novel Derivatives of Artemisinin To Inhibit Toxoplasma Gondii

Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is a medically important infection that is distributed worldwide. Current treatments for the prevention and treatment of toxoplasmosis are of ..

Inhibition of Transplantation Rejection By Suppressing HVEM

Decoy lymphotoxin beta receptor (LT? has potent immune inhibitory activities, and thus represents a promising biologic for the treatment of inflammation, autoimmune diseases and graft-versus-host dise..

Histone Mutant Plasmid Collections

Epigenetics, the study of stable alterations in gene expression that arise during development and cell proliferation, is a popular area of modern bioscience. The epigenetic context in which genes are ..

Use of High Dose Cyclophosphamide in Combination with Anti-Idiotypic Vaccines in Anti-cancer Therapy

Recently, immunotherapy based techniques have been developed for the treatment of various cancers. The central premise underlying immunotherapy for cancer is the presence of antigens which are select..

Use of High Dose Cyclophosphamide in Combination with Immune Therapeutics in Anti-Cancer Therapy

Cyclophosphamide and especially high-dose cyclophosphamide has been used for the treatment of certain autoimmune diseases such as severe aplastic anemia. Low to intermediate doses of cyclophosphamide ..

Method of Identifying Patients Suitable for High-Dose Cyclophosphamide Treatment

Aldehyde dehydrogenases (ALDHs) are intracellular enzymes responsible for oxidizing aldehydes. A number of studies seem to suggest that ALDH confers resistance of cells to cyclophosphamide, which is r..

Rapid Predictive Assay For Malignancies Treated With Polo-like Kinase-1 (PLK1) Inhibitors and Cell Cycle Modulators

Scientists at JHU have developed a pharmacodiagnostic assay for patients treated with targeted therapies directed at modulating the cell cycle, including but not limited to Polo-Like Kinase-1 (PLK1) i..

Protective Effect of Carbon Monoxide (CO) In Stroke

Carbon monoxide (CO) has been shown to mediate both beneficial and deleterious processes in the central nervous system depending on its concentration. CO is produced endogenously through the breakdown..

Novel Breast Cancer Cells That Stably Express a New Orange-red Fluorescent Protein Provides Facile Tracking of Metastatic Progression In Live Animal Model Systems

Modeling human disease states in mice has a profound impact on our understanding of disease progression and treatment development. The need for noninvasive longitudinal monitoring of such model system..

Small Molecules Targeting 5-meCpG Binding Domain Proteins (MBDs) for Cancer Prevention and Treatment, and for Other Clinical Uses

JHU scientists have discovered new small molecules inhibitors of the transcriptional repression pathway mediated by the 5m-CpG-binding family domain proteins (MBD), MBD2 and MeCP2. Both MBD2 and MeCP2..

Inhibition of Vif-Cul5 Interaction Through Use of Zinc Chelator

The Vif ? A3G axis is one of the most promising new drug targets in HIV research. Previous studies have discovered that Vif is an HIV-derived protein that acts to derail antiviral efforts from the ho..

Methods To Reduce Damage From Stroke And Other Neurological Disorders.

Low Voltage, High Mass Range Ion Trap Mass Spectrometer For Mars Atmosphere and Other Harsh Environments

The invention is an ion trap mass spectrometer designed for use on the surface of Mars to detect minute qualities of organic and biological compounds that might indicate the presence of life or former..

Methods to Block or Reduce Damage from Stroke and Other Neurological Disorders

Tamoxifen-resistant MCF-7 Breast Cancer Cell Line

MCF-7 cells serve as a prototypic model system for human breast cancer and their response to secretive endocrine response modifiers (SERM) therapy. MCF-7 cells, upon long term exposure to tamoxifen, ..

Novel Inhibitors of CRAC Channel As Immunosuppressants

T cell activation is essential for immune response. It is primarily responsible for graft rejection upon organ transplantation. Moreover, dysregulation of T cells has been implicated in several autoim..

A Novel Method for Generating and Screening Peptides and Libraries Displayed on Adenovirus Fiber

Antipsychotic Drugs that do not elicit Weight Gain by Screening for Influences on Hypothalamic AMP-Kinase and Histamine H1 Receptors

Atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major side effect of weight gain. Ignorance of the mechanism of thes..

A Novel Cystic Fibrosis Therapeutic Agent

The Consensus Coding Sequences of Breast and Colorectal Cancers

Human cancer is a disease caused by an accumulation of mutations in genes involved in cell cycle regulation. To date only a small fraction of the genes underlying tumorigenesis have been identified, a..

Melanoma Metastasis-associated Genes As Novel Diagnostic and Prognostic Markers and Therapeutic Targets For Melanoma

The incidence of melanoma is increasing at the highest rate for any form of cancer in the United States and the current lifetime risk in the US is 1 in 68. Presently there are few effective systemic t..

Genomewide Analysis of Chromosomal Translocation

Abstract (Set) The cancer genome is quite unstable with many aberrant genetic translocations dispersed across its sequence. Many chromosomal translocations result in chimeric transcripts resulting in..

Monoclonal Antibodies (mAb) Specifically Against Mouse and Human LIGHT and B7-H4

Scientists at JHU have made antibodies against mouse and human LIGHT and B7-H4 molecules. Description (Set) Proposed Use (Set) These mAb could be used specifically to detect the expression of LIG..

Candidate Proteasome Inhibitors that Prevent E6 Mediated p53 Degradation and Selectively Kill HPV+ Cervical Cancer

Selective Fluorescent Labeling of S-Nitrosothiols: S-FLOS

Johns Hopkins University is seeking licensees for a powerful analytical and quantitative technique for S-nitrosylation of proteins. S-nitrosylation is a post-translational protein modification that ca..

ER alpha M4, ER alpha U4, p16 M4, p16 U5, Hin1 M1, Hin1 U2, RASSF1a M1, RASSF1a U1, RAR beta M1, RAR beta U1, Twist BM2, Twist BU5, APC M3, APC U3, Cylin D2 M1, Cyclin D2 U4, 14-3-3 M2, 14-3-3 U3, HIC

Abstract (Set) Plasmid DNAs incorporating human gene-specific promoter sequences altered by sodium bisulfite treatment. Description (Set) Proposed Use (Set) Their use includes serving as reagent..

New Angiogenesis Inhibitors Derived From Fumagillin

Angiogenesis, the formation of new blood vessels, is involved in the pathogenesis of a number of common human diseases, including cancer, diabetic retinopathy, rheumatoid arthritis, and macular degene..

Novel Immunotherapy for Contact Dermatitis

Mouse Model of Human Head and Neck Squamous Cell Carcinoma

PSMA-targeted Nanoparticles for Therapy of Prostate Cancer

MicroRNAs As Targets for Anti-Angiogenic Therapies

Drugs Targeting Cancer Stem Cells

The study of cancer stem cells is important for the development of new cancer treatments. Existing chemotherapeutics may eradicate the bulk of a tumor but residual stem cells may remain to initiate n..

Topical Administration of Peripherally Acting Drugs for the Treatment of Chronic Pain

N171-82Q Huntington's Disease (HD) Mouse Model

This transgenic line expresses an N-terminally truncated human huntingtin cDNA that encodes 82 glutamines and encompasses the first 171 amino acids. The altered huntingtin cDNA is under the control of..

Biocompatible "smart" nanogels as carriers for hydrophobic drugs

The present invention involves a biocompatible nanogel composition for the delivery of hydrophobic substances that are not readily soluble in organic solvents. These nanogels have been designed to con..

The Immediate Early Gene Arc Interacts with Endocytic Machinery and Regulates the Trafficking and Function of Presenilin

Ligands for Nicotinice Acetylcholine Receptors, and Methods of Making and Using Them

One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of the i..

A "Molecular Switch" in Group 1 mGluR Signaling Relevant to Neurological and Psychiatric Diseases

Multitypic Recombinant Adenovirus Vaccines Against HPV

This invention is a vaccine against human papillomavirus infection consisting of recombinant adenoviruses that are engineered to include peptides of the human papillomavirus 16 minor capsid protein (L..

Small molecule as Novel Anti-tumor and Anti-angiogenic Agent

Abstract (Set) JHU scientists found that a known antibiotic that inhibits the type 2 methionine aminopeptidase and possesses anti-angiogenic activity both in vitro and in vivo. It causes both primary..

The Direction of Controlled Heat Specifically to Cancer Cells to Enhance Therapeutic Responses to Combination Therapy

The novel featues outlined in ths invention are: 1. The use of localized limited heat that is specifically directed to the cancer cells and their environment to sensitize the cell to combination thera..

Liposomase for the Tumor-specific Delivery of Chemotherapeutic Drugs

The challenge in developing effective cancer treatments is in achieving specificity so that only cancer cells are destroyed. JHU scientists have developed a novel drug delivery system that overcomes ..

Method of Synthesis of Chemospheres and Chemogel, Hydrogel Embolic Particles and Gel for Locoregional Delivery of Therapeutic Agents and Immunoisolation of Cellular Therapeutics

Description (Set) JHU scientists have developed a method of producing innovative biocompatible compositions useful for variety of therapeutic applications. The biocompatible polymer gel compositions ..

High throughput generation of water-in-oil emulsions for molecular genetic analyses

Researchers have developed a technology called BEAMing (Beads, Emulsion, Amplification and Magnetics), which can assess millions of molecules simultaneously for the study of human genetic variation (..

Mouse Adult Kidney Stems Cells Modulate Function of Dendritic Cells

Abstract (Set) Recent data has suggested that stem cells, such as mesenchymal cells derived from bone marrow, demonstrate an immunosuppressive ability and could represent a new approach for the treat..

Novel Class and Clinical Application of Antithrombotic Agents that Specifically Inhibit Inflammation-related Vascular Occlusion

Inflammation is known to be an integral part of the vascular occlusive events that occur during heart attack and stroke, although the specific pathway that links inflammation to clot formation has no..

Functional Cardiac Tissue Engineering Using Nanostructured Scaffolds for Cardiac Cell Therapy & High-Throughput Drug Screening

This technology incorporates a method to guide the three-dimensional growth and generation of functional cardiac tissues with controlled and enhanced electrophysiological properties using a nanostruct..

Discovery of Novel HTLV-3 and HTLV-4 Retroviruses

Scientists at JHU have recently discovered the existence of two new types of Human T Lymphotropic Viruses (HTL-V), HTLV-3 and HTLV-4, which may be transmitted within humans. The HTLV-4 and HTLV-3 are..

Epigallocatechin-3-Gallate (EGCG) Enhances CD8+ T Cell Mediated Anti-Tumor Immunity Induced by DNA Vaccination

Immunotherapy and chemotherapy are generally effective against small tumors in animal models of cancer, but many tumors can grow rapidly and become resistant to both therapies. JHU researchers have n..

Alteration of the Albumin-bound Protein/peptide Complex (ABPPC) is Biomarker for Disease

JHU scientists have invented a cost-effective, rapid, and sensitive assay that characterizes proteins differentially bound to albumin in diseased and healthy patients and is compatible with current bl..

Formation of Functional Motor units and Recovery from Paralysis Using Embryonic Stem Cell Transplantation

The technology describes the potential of embryonic stem cell-derived motor neurons to functionally replace those destroyed in a paralyzed rat model. JHU researchers have successfully demonstrated the..

ATR-Seckel Cancer Cells for Drug Discovery

Advanced gene targeting methods were used to generate biallelic knock-in point mutations in human colorectal cancer cells that cause a loss of ATR function, but retain enough activity to permit viabil..

Tumor Repressor Genes in the Prevention of Cancer

Some epidemiological studies suggest that many solid tumor types occur less often than predicted in individuals with Down syndrome. Using mouse models of trisomy 21 and cancer, scientists at JHU have..

Sequence Motifs that Direct Nuclear Import of Small RNAs

Small RNA species, such as small-interfering RNAs (siRNAs) and microRNAs (miRNAs), have important roles in gene silencing and possess great potential for the development of novel therapeutics. Researc..

Role of Kv Channels in Neuroregeneration and Protection

Injury to the human central nervous system (CNS) is usually difficult to treat because of the limited regeneration capabilities of the neurons. Evidence suggests that the lack of CNS regeneration is d..

Vaccine to Prevent/Treat Esophageal Cancer in Individuals with Barrett's Esophageal Metaplasia

Esophageal cancer affects approximately 14,000 individuals per year in the United States, is increasing in incidence, and is associated with an exceptionally high mortality rate. The poor outcome in p..

Development of Peptide Antibody Depletion (PAD) and its Application to Mass Spectrometry Sample Preparation

One of the major limitations of mass spectrometry is obtaining mass information on proteins in the presence of contaminating materials or other high abundant proteins that, when present in the sample,..

Embryonic Stem Cells from Animal Models of Motor Neuron Diseases Including Spinal Muscular Atrophy (SMA) and Amyotrophic Lateral Sclerosis (ALS)

Progress in the development of therapies for motor neuron diseases has been hampered by the lack of effective cell culture models. Since spinal motor neurons selectively die in ALS and SMA, an effecti..

Processes for Regulating Blood Glucose in a Mammal and Novel Polypeptides Useful in Nad Biosynthesis

Scientists at JHU have discovered of a novel blood-circulating form of Nampt. This novel isoform a slightly higher molecular mass compared to the intracellular form of Nampt and is mainly secreted by..

Phase 2 Inducers and Related Signaling Pathways Protect Cartilage Against Inflammation/Infection, Apoptosis and Stress

The molecular pathogenesis of arthritis associated with increased chondrocyte apoptosis is earmarked by over-expression of cyclooxygenase-2 (COX-2) in articular tissues. COX-2 inhibitors are efficacio..

TC-1/A2

Scientists at JHU have developed an HLA-A2 expressing tumor mouse model that can naturally process and present E7 antigen via HLA-A2 molecules. Description (Set) Proposed Use (Set) This mouse mod..

A Rapid Assay Using Fine Needle Aspiration (FNA) to Test for 5-fluorouracil Dosing and Efficacy

Scientists at JHU have developed a functional assay for a class of widely used anti-cancer drugs, 5-fluorouracil and related compounds (5FU). The assay is based on Fine Needle Aspiration (FNA) of any ..

The Use of Lumican as an Inflammation Modulator

This technology identifies an extra-cellular matrix protein, lumican, that plays a role in the inflammation pathway. This protein is present in the skin, cornea, intestines and blood vessels, and modu..

Multiple Inversion Flip Flop (MIFF) Vectors

JHU researchers have developed novel Multiple Inversion Flip Flop (MIFF) plasmid vectors for controlling the expression of transgenes that are either stably-integrated or transient. These vectors comp..

SIV Clonal Isolates: SIV/17E-Fr, SIV/17E-C1, SIV/3-11RG, and SIV/3-7

Abstract (Set) JHU researchers have constructed infectious simian immunodeficiency virus (SIV) molecular clones that differ in their Env and Nef proteins. These clones display differences in neurovir..

Identification of E. Coli Determinants Contributing to Bacteremia that Form the Foundation for Development of Vaccines Against E. Coli Bacteremia Andsepsis

E. coli is the most common gram-negative organism causing nosocomial bacteremia and bacteremia in VA and elderly patients. The mortality and morbidity associated with E. coli bacteremia is substantial..

Multifunctional Neck Brace

strengthening of cervical muscles and the prevention of atrophy of cervical muscles; and graduated mobility and improved comfort in patients with a disease attributable to the cervical region of the s..

Augmentation of Endocardial Thromboresistance

A critical function of the endocardium is to maintain local thromboresistance by providing an anticoagulant surface. Thrombomodulin, is expressed on the surface of the endocardium endothelial cells an..

Cell Lines that Express SIV/HIV Receptors and Co-Receptors in the K562 Human Cell Line

Both simian and human immunodeficiency viruses (SIV and HIV) utilize chemokine receptors, with or without CD4, as portals for entry into susceptible cells. JHU researchers constructed a reporter cell..

HOXB7 as a Potential Prognostic Marker and Therapeutic Target in Cancer

Scientists at The Johns Hopkins University have determined that HOXB7, a member of homeobox superfamily of transcription factors, regulates the expression of EGFR/ER2 and ER?and functionally orchestra..

MEK KO Lines for Drug Discovery

MEK knockout in human colorectal cancer cell line HCT116. Description (Set) Proposed Use (Set) MAP kinase/ERK kinase (MEK) is the specific activator of extracellular signal-regulated kinase (ERK)..

Line 1: Pkhd1flox3-4 mouse line, formal name Pkhd1tm1Ggg.; Pkhd1del3-4 mouse line, formal name Pkhd1tm1Ggg.1

Pkhd1flox3-4, when mutated, causes human autosomal recessive polycystic kidney disease (ARPKD). The Pkhdlde13-4 allele results after Cre-mediated deletion of exons 3 and 4. Homozygosity for this allel..

Neuroprotective Actions of Polyphenols, Flavonoid Derivatives and Their Respective Extracts

Polyphenols, such as resveratrol, have been linked to many health benefits. This widespread belief stems from its intrinsic antioxidant properties that protect against oxidative damage. Recently, oth..

NAC-1 Monoclonal Antibody

Scientists have developed a human NAC-1 monoclonal antibody. The antibody can be applied by immunohistochemistry, Western blot and immunoprecipitation to detect NAC-1 protein expression. Description..

Estrogen Receptor in Normal (ERIN) Cells

There is no ideal system for studying pre-neoplastic cells that are ERpositive due to the inability to establish an estrogen growth stimulated but non-tumorigenic breast epithelial cell line. Scientis..

Promoters for Neural Regeneration

Background Injury to the human central nervous system (CNS) is usually difficult to treat because of the limited regeneration capabilities of the neurons. Evidence suggests that the lack of CNS regene..

Compounds with Effects on Potassium Channels

KCNQ channels play a role in cardiac and neuronal membrane excitability. Scientists at JHU have identified a series of novel compound that potently activates KCNQ channels. Initial studies of electrop..

Inducing and Inhibiting T Cell Tolerance with A2a Receptor Agonists and Antagonists

T cells play a critical role in fighting disease and infection. However, when T cells recognize and attack normal or non-infected cells, autoimmunity ensues. A contrasting, but similarly detrimental s..

The MR-eye: Methods and Devices for Local MRI

The present invention is a novel method to lock the MRI frame-of-reference to an internal device, where the RF excitation is confined to the immediate region surrounding the probe. Two dimensions are ..

Protein-Encapsulated Aligned Fibers by Electrospinning for Enhanced Peripheral Nerve Regeneration

We have developed novel protein-encapsulated fibrous meshes that are composed of micro-/nano-sized aligned fibers. The encapsulated protein in the fibers can be released in a sustained manner for up t..

MR-visible and radiopaque microcapsules for use as embolic agents and for immunoisolation of cellular therapeutics

Immunoisolation of cells through microencapsulation is a means to prevent their immune destruction following transplantation. To date, microencapsulation has shown great clinical potential for a wide ..

A. phagocytophilum Monoclonal ab hybridomas

Researchers at JHU have created hybridomas producing monoclonal antibodies reactive with the obligate intracellular bacterium Anaplasma phagocytophilium 44kDa antigens (Msp2), AnkA and unidentified la..

Novel Compounds that Target Estrogen Receptor (ER) Positive. Tamoxifen-resistant Breast Cancers

The drug tamoxifen is widely used to treat estrogen receptor (ER) positive breast cancer and to prevent relapse. However, half of all recurrences in breast cancer patients are resistant to tamoxifen ..

Trioxane Dimers Having Surprisingly High Anticancer Activities and Surprisingly Long-lasting Antimalarial Activities

Artemisinin (1), a monomeric 1, 2, 4 trioxane, is usually administered for the treatment of multi-drug resistant malaria. However, studies have determined that artemisinin not only possesses excellent..

Co-assembling Peptide Hydrogels

Peptide-based hydrogels have become popular for biomedical applications such as tissue engineering and drug delivery due to their biodegradable and bioresorbable properties. For use in vivo, hydrogels..

Developing a High-throughput Screening Method for Identification and Validation of T Cell Epitopes Based Upon the Mass Spectral Analysis of Antigens Bound to Class II HLA-DR Constructs

All currently established methods for the identification of immunogenic epitopes are extremely tedious, time consuming and frequently unsuccessful. The identification of high throughput methods to is..

A Fast, Cell-based, High-throughput Assay for the Identification of Compounds with DNA-interstrand Crosslinking Capability

Using somatic cell gene targeting, isogenic cell clones were created from the colorectal cancer cell line RKO. Each KO cell line differed only in the allelic status of one Fanconi Anemia (FA) gene, ei..

Novel methods for genetic calcium channel blockade

The development of left ventricular hypertrophy (LVH), irrespective of etiology, confers an incremental risk of adverse outcomes in the general population and in patients with different forms of card..

TGFbeta Antagonists, Including AT1 Receptor Blockers, Rescue the Multisystem Pathogenesis of Marfan Syndrome

This invention is based on the discovery that excessive activity of an important signaling protein, TGF?likely underlies a variety of problems in Marfan syndrome, including the tendency to develop emp..

Prostate Specific Membrane (PSMA)-binding Peptides Useful for Targeted Therapy for Cancer

Prostate-Specific Membrane Antigen (PSMA) is a glutamate carboxypeptidase II that is expressed by normal prostate epithelium and is even more highly expressed by a large proportion of prostate cancers..

Peptide Substrates for Fibroblast Activation Protein (FAP) that can be Used to Generate FAP-activated Prodrugs and Protoxins

Fibroblast activation protein alpha (FAP-alpha) is a membrane bound serine protease that is only produced by reactive stromal cells present within sites of epithelial cancers. FAP-alpha is not express..

Antibody Based Anti-HIV-1 Microbicide Targeting a Host Protein

Development of microbicides to prevent HIV-1 transmission to women plays a valuable role in stemming the worldwide epidemic of the disease. In order to address some of the shortcomings of microbicide..

Johns Hopkins University PROTEIN-DB2 Database System

Genomic data collection follows the workflow of amplification of DNA expression, amplified DNA extraction, high-throughput sequencing, and subsequent processing/analysis of the sequence data. DNA itse..

Emission Ratiometric Kinase Activity Reports in High Throughput Drug Screening and Analysis

Protein phosphorylation is one of the major regulatory mechanisms controlling cellular functions and aberrant kinase activities are found to form the molecular basis for many disease phenotyes. As a r..

Chemical Control of Trk Signaling in Mice

Neurotrophins are a family of molecules that encourage survival of nervous tissue by secreting factors in a neuron's target field, and act by prohibiting the neuron from apoptosis. The neurotrophin fa..

Tetrahydrobiopterin for Treatment of Cardiac Failure and Remodeling

Tetrahyrdobiopterin (BH4) is an obligate cofactor for the aromatic amino acid hydroxylases (tyrosine, tryptophan, and phenylalanine), as well as for the nitric oxide synthases. It is currently used cl..

Identification of Novel Putative Endogeneous Angiogenic Protein Inhibitors

The present invention identified over 70 novel putative endogenous angiogenesis inhibitors using methods of bioinformatics. Classification of these inhibitors is based on conserved domains of known a..

Web-Based Diabetes Data Management Application

Intensive control of blood glucose levels may delay the onset and progression of microvascular complications that contribute to the morbidity and mortality of patients with type 1 and type 2 diabetes..

Johns Hopkins Diabetes Management Program

The invention encompasses a team of health care professionals who directly manage the pharacologic, nutritional and educational components of the medical care plan for hospitalized patients with diabe..

New uses for old drugs: Identification of Hedgehog pathway antagonists previously tested in humans

Hedgehog (Hh) pathway activity is responsible for the growth of lethal cancers such as small cell lung cancer, and carcinomas of the esophagus, stomach, pancreas, biliary tract, and prostate, and acc..

A New Method to Increase Memory T Lymphocytes and Enhance their Functions for Resistance of Cancer and Infections

CD137 has long been recognized as a co-stimulatory receptor for growth and functional maturation of recently activated T cells in the presence of T cell receptor signal. Now, researchers at JHU have d..

pT2cfosGW

A current hypothesis is that sequences conserved over greater evolutionary distances are more likely to be functional than sequences that are less well conserved. In order to identify non-coding regul..

Site-specific Modification of the Human Genome Using Custom-designed ZFNs

Scientists at JHU have designed sets of Zinc Finger Nucleases (ZFN) to target mouse genes, namely the tyrosinase (mTYR) and CFTR (mCFTR) and human genes, namely the CCR5 co-receptor (hCCR5) through w..

Molecular Targets for the Anti-cancer Natural Product Pateamine A

v The natural marine product Pateamine A (PatA) is a potent anti-tumor and pro-apoptotic agent. Until recently, PatA?s mechanism of action was unknown until scientists at JHU determined that the prote..

S9

Cystic Fibrosis bronchial epithelial cell line isolated from a patient with genotype ?508 /W1282X. IB3-1 Cells were immortalized with adeno12SV0 and later infected with a viral vector AAV carrying CF..

A Novel Statistical Method to Identify Robust Prostate Cancer Marker Genes

The most commonly used diagnostic screen for prostate cancer (measurement of levels of prostate specific antigen) is now known to function very poorly as a disease biomarker. The test developed in thi..

C38

JHU scientists have created a Cystic Fibrosis bronchial epithelial cell line that was isolated from a patient with genotype ?508/W1282X. Cells were immortalized with adeno12SV0 and later transfected ..

Interference of the mir-17 miRNA Cluster as a Novel Cancer Therapeutic Strategy

The MYC cancer gene increases the expression of a cluster of microRNAs that are implicated in the development of human cancers. Researchers at JHU have discovered that MYC regulates a growth regulator..

RAS KO Lines for Drug Discovery

RAS gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Parsons et al., 2005 Description (Set) Proposed Use (Set) The cell lines described in..

Neuroprotection Actions of EP1 Receptor Drugs

Prostaglandin E2 is the primary product of arachidonic metabolism and is synthesized via the prostaglandin and cycloxygenase pathways. The hormone-like chemical has been shown to affect the central n..

A New Method for High-efficiency Integration of Transgenes into Bacterial Chromosomes without a Drug Marker

This invention allows the insertion of foreign DNA into an innocuous site in the bacterial chromosome using the site-specific recombination system of Tn7. Drug selection is not required since this int..

Arginase, A Target Enzyme for the Treatment of Myocardial Dysfunction in Aging and Heart Failure

We have identified a novel method to treat heart failure and age related myocardial dysfunction by inhibiting the enzyme Arginase. The seminal observations underlying this claim involve the following..

Revolving Robotic Needle Driver

Abstract (Set) Image-guided robots are manipulators that operate based on medical images. These are modern medical tools with applications in most medical fields, allowing the physicians to perform i..

Genome-wide Direct Transcription Measurement using Array-based Assay of Labeled Nascent RNA

Description (Set) JHU scientists have developed, optimized and validated an innovative approach for study of nascent RNA transcription. Post-transcriptional regulation of gene expression constitutes ..

Tandem L2 Fusion Vaccines for Prevention of Human Papillomavirus Infection

Abstract (Set) HPV infection causes 5% of human cancers worldwide. Prevention of HPV infection will eliminate HPV associated cancers and their precursors. However, current licensed vaccines are deriv..

L2 Lipopeptide Vaccine for Prevention of Human Papillomavirus Infection

Abstract (Set) Human papillomavirus (HPV) infections are the most common sexually transmitted infection in the United States. Infection by over 15 different oncogenic HPV genotypes is a cause of cerv..

Cardiac Stem Cell and Myocyte Secreted Paracrine Factors

Abstract (Set) Stem cells hold the promise to revolutionize future reparative medicine through the development of stem cell-based therapies. Transplanting stem cells (either embryonic or adult derive..

Imaging Methods for Assessment and Quantification of in vivo Antigen Capture and Vaccination

Abstract (Set) Immunization has eradicated many harmful infectious diseases in the Western world. This is commonly achieved by injecting individuals with attenuated pathogens such as viruses and bact..

Ras-regulated microRNAs as a novel anti-cancer therapeutic strategy

Abstract (Set) MicroRNAs (miRNAs) are 18-24 nucleotide RNA molecules that regulate the stability or translational efficiency of target mRNAs. miRNAs are frequently dysregulated in cancer cells and ca..

CisGenome Software

Abstract (Set) Chromatin immunoprecipitation followed by genome tiling array analysis (ChIP-chip) or by massively parallel sequencing (ChIP-seq) is an extremely powerful tool to understand gene regul..

Technique for Identifying and Measuring Narp in Plasma

Abstract (Set) JHU scientists have developed a method of concentrating Neuronal activity regulated pentraxin (Narp) in plasma using taipoxin bound affinity beads. The concentrated Narp is detected us..

Mosquito-based Malaria Transmission-blocking Antibodies

Abstract (Set) A single effective vaccine against malaria is lacking. As such, the global research effort has focused on developing a "cocktail" vaccine, wherein different life stages of the parasite..

Tumor Suppressor MicroRNAs Controlling Cancer Cell Growth

Description (Set) Johns Hopkins scientists have discovered two microRNAs that are expressed in normal blood cells, but are not expressed in virtually any of the leukemia-lymphoma cell lines and prima..

Method for Investigating Long-Range Chromatin Interactions In Vivo

Abstract (Set) The packaging of DNA into chromatin, the complex of DNA and protein that makes up chromosomes, is an important mechanism for regulating gene expression. Recent studies demonstrate that..

Cost-Effective Method for High-Throughput and Quantitative Analysis of DNA Methylation

Abstract (Set) Investigators at Johns Hopkins University developed a simple and cost-effective approach to detect and quantify the status of DNA methylation, termed MSqFRET. This method couples the w..

http://www.jhttportal.jhu.edu/TechTransfer/TechnologyLocator.asp

Description (Set) JHU inventors have identified a population of microRNA (miRNA) associated with a critical neurotransmitter transporter gene regulatory region. miRNA has roles in modulating gene exp..

Novel Antibiotic Treatment of Gliosarcoma Reduces Tumor Size and Increases Survival

Abstract (Set) The present invention is directed to methods of using a bacteriostatic antibiotic to treat glioma and other brain tumors including astrocytoma, oligodendroglioma, glioblastoma multifor..

LRRK2 Fly Model for Parkinson's Disease

Abstract (Set) Mutations in the leucine rich repeat kinase (LRRK2) gene causes late onset autosomal dominant Parkinson's disease (PD). The LRR protein has two enzyme activities (kinase and GTPase) wh..

Methods to Reduce Mesh Spacing of the Protective Mucus Barrier

Description (Set) Human mucus forms a protective barrier to toxins and infectious pathogens on all the most susceptible surfaces of the body such as the lung airways, gastrointestinal tract, nose, ey..

The Method to Enhance Death of Cancer Cells

Abstract (Set) B7-H1 is an immunoglobulin-like immune suppressive molecule broadly detectable on the majority of human and rodent cancers and its functions have been attributed to delivering an inhib..

Radiolabeled Analogs of Cyclopamine for Imaging Hedgehog Signaling

Description (Set) The hedgehog (Hh) signaling pathway is increasingly recognized as an important therapeutic target in cancer. When Hh signaling goes awry patients may develop a wide variety of tumor..

Immunoliposomal Delivery of Vaccine to the Spleen

Abstract (Set) A fundamental problem in all vaccination methods is to present the target antigen to the appropriate population of cells so that the immune system will be sufficiently activated to mou..

Molecular Insights into Breast Cancer Prevention and Therapeutics Involving Novel Genistein Analogs

Abstract (Set) Cancer is the second leading cause of death in the U.S. and claims the lives of around 555,000 Americans each year. An estimated 1.3 million new cases of cancer are reported in the U.S..

Rapid Induction of Cancer Cell Death by Synergistic Treatment of Tetra-O-methyl Nordihydroguaiaretic Acid (M4N) with either Two Specific Kinase Inhibitors

Abstract (Set) M4N is an anti-cancer drug candidate, which is currently under the first phase of clinical trials. Although M4N can reduce tumor cell growth; it fails to induce quick tumor cell death...

Dually Targeting the PI3K/Akt and MAP Kinase Pathways in Poorly Differentiated and Undifferentiated Thyroid Cancer Cells has High Therapeutic Promise

Abstract (Set) JHU scientists have discovered an innovative method of targeting aggressive thyroid cancers that are resistant to conventional treatment. Poorly differentiated anaplastic thyroid cance..

Detection of Virus Exposure as an Etiological Agent in Patients with Sudden Onset of Psychosis

Description (Set) JHU scientists have developed an assay based on detection of certain viral antigens in patients with a sudden and unexplained onset of psychiatric symptoms. This discovery is rooted..

Salivary Rinse and Serum Detection Test for Head and Neck Cancer

Description (Set) A Johns Hopkins University investigator has identified unique profiles of hypermethylated gene promoters that are effective markers of risk for head and neck cancer. Head and neck s..

Beta-3 Adrenergic Receptor Agonists Reduce Cardiac Hypertrophy and Heart Failure

Abstract (Set) This invention is based on the discovery of a novel role for beta-3 adrenergic receptors (B3AR) in the control of cardiac hypertrophy when the heart is under physical stress. The preci..

Cancer Immunotherapy Using Irradiated Tumor Cells Secreting Hsp 70

Abstract (Set) Ovarian cancer is responsible for the highest mortality rate among patients with gynecologic malignancies. Therefore, there is an emerging need for innovative therapies for the control..

Novel Cell Surface Receptor Variants as Biomarkers for Hormone-Refractory Human Prostate Cancer

Abstract (Set) Prostate cancer cells depend on hormones and hormone receptor activity for growth and survival. Some prostate cancer cells progress to a phenotype that is aggressive and no longer susc..

High Affinity Small Molecule Inhibitors of Hepatitis C NS3/4A Protease

Description (Set) Hepatitis C virus (HCV) infection is a growing global health problem with over 3 million new cases of HCV infection each year. Johns Hopkins University scientists have discovered a ..

Monoamine oxidase (MAO) inhibitors reduce cardiac hypertrophy and prevent heart failure

Description (Set) JHU scientists have developed a method to reduce heart muscle cell changes that lead to heart enlargement and congestive heart failure, using agents that inhibit monoamine oxidase (..

Novel Peptide And Delivery Method For The Treatment Of Human Cancers

Description (Set) The PIK3 signaling pathway has recently been recognized a major player in the regulation of cell survival and cell proliferation as it relates to cancer. Scientists at JHU have util..

A Predictive Test for Determining Chemotherapy Regimens in Patients with Cancer

Abstract (Set) The ability to predict sensitivity to individual cytotoxic chemotherapies could improve treatment response and survival of cancer patients. There is currently no method in routine use ..

Carcinoembryonic Antigen as a Potential Biomarker for use in Targeted Drug Delivery Applications as well as Other Therapeutic Strategies

Abstract (Set) Blood-borne metastasis is a highly regulated and dynamic process, whereby cancerous cells separate from a primary tumor, migrate across blood vessel walls into the bloodstream, evade h..

Mutational Analysis of the Serine-threonine Kinome in Colorectal Cancers

The invention describes novel mutations in serine-threonine kinase genes within the Phosphatidylinositol-3-OH Kinase (PI(3)K) pathway in patients with colorectal cancer. Details are described in the p..

Mouse Monoclonal Antibody 8A2

Abstract (Set) This technology is a mouse monoclonal antibody, which specifically recognizes vertebra SUMO-2 and SUMO-3. SUMOylation is essential for cell-cycle regulation in invertebrates; however, ..

Modulation of Regulatory T cell (Treg) Function

Abstract (Set) Regulatory T cells (Treg) are a subset of the CD4 T cell population that down-modulate an immune response. In some diseases, i.e. autoimmunity, Treg activity can prove beneficial ..

Instrument System for Managing and Cherry Picking Microorganism Collections

Large biomaterial collections require precise and selective access to a subset of material under sterile conditions. JHU researchers have invented a novel integrated instrument system built from exist..

Short Chain Fatty Acid (SCFA) - Carbohydrate Bifunctional Hybrid Molecules with Novel Anti-cancer Properties

Butyrate, a natural short chain fatty acid (SCFA), is well-established to have anti-cancer properties via its ability to induce cell cycle arrest and apoptosis in cancer cells. Currently, several clin..

Hi-Throughput Assay for Screening Small Molecule Inhibitors of Uracil DNA Glycosylase

Uracil DNA glycosylase (UDG) is one of the primary enzymes that prevents the incorporation and accumulation of deoxyuridine in genomic DNA. The identification of pharmacologic agents that inhibit UDG ..

Total Human Serum Free IgE Immunoenzymetric Assay (IEMA)

Xolair (generic name, omalizumab) is currently approved by the FDA for the treatment of extrinsic asthma. Presently, there are no serological markers or assays for monitoring the efficacy of prolonge..

Large-scale Survival, Differentiation and Structural Integration of Human Neural Stem Cells Grafted into the Adult

The present invention provides methods and compositions for treating spinal cord diseases and injuries. The methods involve transplanting neural stem cells which have been previously expanded in vitro..

Inhibition of Ischemia-induced Arrhythmias by Blocking Mitochondrial Inner Membrane Ion Channels

This invention describes a method for preventing and/or terminating ischemia-related arrhythmias by targeting the mechanism responsible for the electrical instability occurring during an ischemic epis..

Novel Drugs for the Treatment of Optic Nerve Disease

A small molecule library was screened using an RGC cell culture system for novel factors that promote RGC survival and outgrowth. Five novel compounds have been identified that promote the development..

Method for identifying mutations in coding and non-coding DNA

Annotation of the completed human genome has demonstrated that about 1.5 % encodes protein. About twice (roughly 3.5%) falls within non-coding sequence and is suggested to be functional based on exten..

Gowth of Mesenchymal Stem Cells Under Non Adherent Conditions for Clinical Applications

The use of bone marrow derived mesenchymal stem cells (MSC) has been proposed for a number of regenerative therapies including repair of myocardial tissue. The data to date has suggested improved fun..

Immortalization of Nociceptive Dorsal Root Ganglion Sensory Neurons

This invention involves a novel method to immortalize nociceptive dorsal root ganglion (DRG) neurons. DRG neurons are terminally differentiated cells that extend long axons to their target tissues. Mo..

Neuropilin-1 Sema Mice

Neuropilin-1 (Npn-1) is a receptor that binds ligands from structurally distinct families like semaphorins (Sema) and vascular endothelial growth factors (VEGF). Npn-1 is a type I transmembrane protei..

Reactive Oxygen Generating Enzyme Inhibitor with Nitric Oxide Bioactivity and Uses Thereof

In the US, CHF is the number one cause of hospitalization in people over age 65, and it affected approximately 5 million people in 2004. This translates into a potential cost of $29 billion for the he..

A Compression Device for Enhancing Normal/Abnormal Tissue Contrast in MRI

This invention is a pneumatic device for detecting breast cancer with MRI. The device enables imaging of the elasticity (stiffness) of the tumor and mechanical properties of the surrounding tissue thr..

Inhibiting Binding of Inducible Nitric Oxide Synthase to Cyclooxygenase-2 to Treat Inflammation

Cyclooxygenase (C0X2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Inducible NOS specifically binds to C0X2 and S-nitrosylates it, enhancing C0X2 catalytic activity..

Targeting of Stat-3 Signaling in the Hematopoietic System Evokes Multicomponent Therapeutic Antitumor Immunity

The immune system can act as an extrinsic suppressor of tumors. Therefore, tumor progression depends in part on mechanisms that down modulate intrinsic immune surveillance. Identifying these inhibito..

HAUSP KO Lines for Drug Discovery

HAUSP (also known as USP7) deubiquitinase gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Cummins et al., 2004a (see below) Description (Se..

XIAP KO Lines for Drug Discovery

X-linked inhibitor of apoptosis protein (XIAP) gene knockouts of human colon cancer cell lines. Details are described in the paper by Cummins et al., 2004 (see below). Description (Set) Proposed ..

DEC1 KO Lines for Drug Discovery

Deleted in esophageal cancer 1 (DEC1) gene knockouts of the human keratinocyte cell line, HaCaT. Details are described in the paper by Zawel et al., 2002 Description (Set) Proposed Use (Set) The ..

CHK2 KO Lines for Drug Discovery

Chk2 protein kinase gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Jallepalli et al., 2003 (see below). Description (Set) Proposed Use (..

RAF KO Lines for Drug Discovery

BRAF kinase gene knockouts of human cancer cell lines. Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for novel molecules that target the ..

Dicer KO Lines for Drug Discovery

Dicer RNase gene knockouts in human cell lines. Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for novel molecules that target the miRNA ..

PIK3CA KO Lines for Drug Discovery

PIK3CA knockouts in human colorectal cancer cell lines HCT116 and DLD1. Details are described in the paper by Samuels et al., 2005 Description (Set) Proposed Use (Set) JHU scientists have recentl..

SMAC KO Lines for Drug Discovery

Second mitochondrial-derived activator of caspase (SMAC; also known as Diablo) gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Kohli et al., 2..

p16 KO Lines for Drug Discovery

p16 tumor suppressor gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Bachman et al., 2003 Description (Set) Proposed Use (Set) The cell l..

PTEN KO Lines for Drug Discovery

PTEN is a tumor suppressor gene that is frequently mutated or deleted in a variety of human cancers . PTEN functions primarily as a lipid phosphatase and plays a key role in the regulation of the PI3..

MTAP KO Lines for Drug Discovery

Methylthioadenosine phosphorylase (MTAP) plays an important role in the salvage pathway for the synthesis of adenosine. The loss of MTAP function has been implicated in a variety of cancers. JHU resea..

Selectively Targeted Histone Deacetylase Inhibitors

Inhibitors of histone deacetylases (HDAC) are regarded as an important approach to cancer chemotherapy, since they disrupt the aberrant cellular metabolism that occurs in many tumor types. The HDAC in..

Use of Consensus Sequence as Vaccine Antigen to Enhance Recognition of Virulent Viral Variants

Vaccines for diverse viruses will be most effective when they direct the recipient?s response to recognize the most virulent form of the organism. Scientists at JHU have found that circulating strains..

Generation of Isogenic Lines Differing Only in MLH1 Status

JHU researchers have created matched cell lines which are isogenic, differing only in the MLH1 alleles. One line has two defective alleles, the other has one defective allele and one normal (wild-type..

A Novel Genetic Approach to inhibit or Eliminate the Tumorgenicity of Human Embryonic Stem Cells and/or their Derivatives After Transplantation

Pluripotent embryonic stem cells have enormous potential for providing an unlimited supply of multipotent and specialized cells, such as brain and heart cells, for transplantation and cell-based thera..

B(subscript 1)-Insensitive T(subscript 2) Magnetization Preparation for Magnetic Resonance Imaging at High Field

T2 magnetization preparation is a commonly used MRI technique that enhances the contrast between arteries and surrounding tissues. Recently, high field imaging has shown promising results in acquiring..

Identification of PSCA as an Immune Relevant Target of Antitumor Immune Responses

Prostate Stem Cell Antigen (PSCA) was previously identified as a biomarker for pancreatic and prostate cancer. JHU researchers have shown that a pancreatic cancer vaccine induced immune responses agai..

New Analogs of the Hormone 1(alpha)25-Dihydroxyvitamin D with Side Chain Carbonyl Groups

Medicinal chemists are designing analogs to be at least as potent as, but less calcemic than, the natural hormone la, 25-dihydroxyvitamin D3 (calcitriol) for chemotherapy of diverse human illnesses. S..

Strategies for Designing Drugs that Target the Sir2 Family of Enzymes to Treat Multiple Diseases

Sir2 enzymes comprise a unique class of NAD+ -dependant protein deacetylases that are involved in a broad range of biological processes including transcriptional silencing, aging, fat mobilization an..

High Fidelity DNA Display for the Evolution of Combinatorial Libraries

This invention relates to a method of producing combinatorial libraries from non-biological molecules coupled with replication of selected compounds. Individual molecules used to construct the library..

Platelet Endothelial Cell Adhesion Molecule-1 Gene Polymorphism and its Soluble Level are Associated with Severe Coronary Artery Stenosis in Chinese and Asian Indians

Many established risk factors in atherosclerosis and Coronary Artery Disease (CAD) have been defined for Caucasians but not for other ethnic groups. For example, the Asian Indians have 4 times higher ..

High Fidelity DNA Display for the Evolution of Combinatorial Libraries

Function of GDE Protein Family in Cellular Differentiation

This technology describes a novel retinoid-inducible gene, GDE2 (glycerophosphodiester phosphodiesterase 2) that encodes a 6 TM protein and is necessary to drive spinal motor neuron differentiation in..

PDE Inhibitors in Immunotherapy

Defects in the immune system of tumor-bearing hosts can dramatically preclude effective immune-therapy. JHU researchers and others have previously described some of the cellular and molecular mechani..

A method for high-efficiency clonal isolation and expansion of human embryonic stem cells

JHU researchers have developed a method and identified growth factors for high efficiency cloning, clonal expansion and subculture of human embryonic stem (hES) cells. The invention further describes ..

Facile Modification of Collagen Directed by Synthetic Peptides

mechanical properties. Such modification may allow attachment of bioactive agent that can bring in designed bioactivity to natural collagen. Most of the techniques practiced today for collagen modific..

Method for the direct extraction of isothiocyanates into the seed oil from glucosinolate-containing plant seeds

JHU researchers have developed a methodology for simple, reliable, stable, and inexpensive incorporation of plant isothiocyanates into oils such as natural plant seed oils. Some plant isothiocyanates..

Diagnostic Tool for Diagnosing Benign Versus Malignant Thyroid Lesions

Thyroid cancer represents 1% of all malignant diseases and it is estimated that 5-10% of the population will develop a clinically significant thyroid nodule during their lifetime. The best available t..

Methods and Compositions for Treatement of Intraepithelial Neoplasia

The present invention provides for compositions, kits and methods for treatment of intraepithelial neoplasia, where the compositions include catecholic butanes, which include NDGA derivatives Paten..

BACE2 Knockout Mice

Two beta-secretases termed BACE1 and BACE2 have been shown to generate the Alzheimer's disease Abeta peptides. To examine the physiological roles of BACE2 and to determine whether BACE2 is the major ..

Multi-turn Element RF Coil Array for Multiple Channel MRI

An RF coil assembly for use in a multiple receive-channel MRI system is provided. The RF coil assembly is configured as a multi-turn-element RF coil assembly 200 to operate as a surface-coil array in ..

Pleiotrophin is a Neurotrophic Factor for Spinal Motor Neurons and Dorsal Root Ganglion

This invention utilizes pleiotrophin (PTN), a growth factor of the cytokine family, as a neurotrophic factor for both the motor and the sensory neurons of the PNS. In animal and tissue culture models,..

Implantable Microstimulators for Gastrointestinal Tract

This technology constitutes implanting neuromuscular micro-stimulators with an endoscope into the gastrointestinal tract. The micro-stimulators are targeted to areas of dysfunction, and stimulate or ..

Pyruvate Dehydrogenase Kinases as Therapeutic Targets for Cancer and Ischemic Diseases

This invention addresses two desired outcomes relating to cells exposed to ischemic or low oxygen tension by modulating the activity of a mitochondrial matrix enzyme. Tumor cells that have low oxygen ..

Development of Novel Approaches to Combinatorial Antifungal Drug Therapy

This invention relates to a method of treating fungal infections. Fungal infections can be life-threatening to transplant patients, cancer chemotherapy patients, AIDS patients and others in immunocomp..

A Dwarf Mouse with Growth Hormone Deficiency Due to Targeted Ablation (Knock Out) of the GHRH Gene

The proliferation of pituitary somatotroph cells and the synthesis and secretion of GH are under the stimulatory control of the hypothalamic peptide GHRH. GHRH is initially synthesized as pre-prohormo..

Use of Amniotic Fluid (AF) in Ocular Disease

Human amniotic membrane (HAM) has been used successfully in recent years to treat various ocular ailments such as ocular chemical burns, corneal ulcers, and persistent corneal epithelial defects. The ..

Use of Amniotic Fluid (AF) in Ocular Disease

Emission Ratiometric Indicators of Intracellular Cyclic AMP and Epac Activation

The classic second messenger, cAMP, coordinates many cellular functions via its effectors such as Epac (exchange proteins directly activated by cAMP) and PKA (cAMP-dependent protein kinase). JHU inven..

Transgenic Mice that Express Human Superoxide Dismutase 1 with the Following Mutations (1) a Double Mutation at Residue 46 and 48 with Histidine 46 Mutated to Arginine and Histidine 48 Mutated to Glut

Mutations in superoxide dismutase 1 cause familial forms of amyotrophic lateral sclerosis (ALS). To investigate potential mechanisms of disease pathogenesis, transgenic mice that express human superox..

Imaging Tissue Deformation Using Strain Encoded (SENC) Magnetic Resonance Imaging (MRI

Strain Encoded (SENC) MRI is a novel technique for the direct imaging of regional deformation (contraction and stretching) or elasticity of tissues. Deformation of tissue results in changes in intensi..

Fluorescence Assay for Type IB DNA Topoisomerases for Use in High-Throughput Screening of Small Molecule Libraries

This invention describes the first continuous spectroscopic assay for DNA topoisomerase IB that allows monitoring of the reaction under multiple turnover conditions. As these enzymes are established ..

LOI of lgf2 Increases Intestinal Stem Cell Compartment and Adenoma Formation

This invention provides a strategy for identifying patients at risk of colorectal cancer, and likely other tumor types, by the discovery and identification of an expanded stem cell population in such ..

New Inhibitor of HIV-1 Replication, Ubiquitin Like Protein ISG15

The AIDS epidemics are still not limited, especially in the developing countries. The antiviral therapy used in this country is not affordable in the undeveloped countries. In the United States, curre..

OS-9 Interacts with Hypoxia-inducible Factor 1(alpha) and Prolyl Hydroxylases to Negatively Regulate HIF-1 Activity

Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis in metazoan species and mediates changes in gene transcription in response to changes in cellular oxygenation. ..

Cloning and Isolation of the Large Ribosomal Subunit Proteins from E. coli for the in vitro Reconstitution of functional 50S Subunits

For the first time, JHU researchers have cloned, expressed and purified each of 34 individual large ribosomal subunit proteins for E. coli for use in vitro ribosome reconstitution reactions. The ready..

Modification of Professional Antigen-Presenting Cells with Small Interfering RNA (siRNA) Targeting BAK and/or BAX Can Enhance DNA Vaccine Potency

dendritic cell survival by co-administering DNA encoding antigen with DNA encoding inhibitors of apoptosis to DCs. We previously tested a variety of anti-apoptotic factors for their ability to enhance..

The Use of Cerebralspinal Fluid as Inter-subject Normalization Reference Standard for Magnetization Transfer Weighted Imaging

This invention describes the use of cerebrospinal fluid (CSF) as an inter-subject reference standard for magnetization transfer (MT) imaging. This is useful in cases where the standard MT referencing ..

HMG-1 transgenic mouse

The HMG-I/Y gene is overexpressed in human cancer, although a direct role for this gene in transformation had not been established. JHU researchers have generated transgenic mice with HMG-I targeted t..

Control of Proliferation and Apoptosis in Cancer Cells

pp32 (ANP32A) is a protein expressed in stem-like normal cellular compartments and in human cancers, such as breast and prostate, that exerts multiple complex functions. Collectively appear to control..

Identification of a Specific Ligand for Siglec-8

JHU scientists have created a unique, carbohydrate-based chemical structure that binds to the cell surface protein Siglec-8, which is expressed by human eosinophils, basophils and mast cells. Siglec-8..

Hypomorphic Mouse Mutant of PASG, an SNF2L factor, that leads to growth retardation and premature aging that is associated with replicative senescence, genetic instability, decreased stem cell expansi

Researchers at JHU have shown that PASG (Proliferation Associated SNF2-Like gene, also termed lsh or SMARCA6) is essential for properly maintaining DNA methylation and gene expression patterns which a..

Genetic Modification of Cells Prior to Delivery to the Heart so as to Improve Electrical and Contractile Function

Heart failure (HF) is a major public health problem in the United States. Despite great strides in the management of HF, it is still associated with high mortality and morbidity. Cardiac transplantati..

TH, Bcl Conditional KO mouse

Transgenic mouse that lacks expression of Bcl-x in Tyrosine Hydroxylase-positive Neurons. Description (Set) Proposed Use (Set) This mouse is a useful tool for the molecular study of neural disor..

TH - Cre Mouse

A transgenic mouse, which produces the Cre Recombinase in Catecholaminergic Neurons. Description (Set) Proposed Use (Set) This mouse is a useful tool to study, at the molecular level, neuronal c..

Potent, Simplified Derivatives of Immunosuppressive Agents

Pateamine A (PatA), a metabolite from the marine sponge Mycale, is a potent inhibitor of the intracellular signal transduction pathway that emanates from the T-cell receptor and leads to the transcri..

PXA1, PXA2, PXA3, PXA4, PXA5, PXA6

The invention consists of low-passage cell lines generated from primary pancreatic cancers established as nude-mice xenografts, and subsequently passaged in vitro. Description (Set) Proposed Use (..

pFex: An Adenoviral Fiber Exchange Shuttle System

The value of re-targeted adenoviral vectors is becoming apparent in the current age of gene therapy. However, the large size and complex organization of adenoviral vectors makes construction of re-tar..

Shh Light2 Cells

Cell line derived from the NIH/3T3 cell line transfected with GLI-responsive Firefly luciferase reporter from H. Sasaki and a constituitive Renilla-luciferase expression vector. Description (Set) ..

293 EcR Shh

Cell line for ecdysone-inducible expression of Shh. Description (Set) Proposed Use (Set) This cell line can be used to discover compounds that block activation of the Hh response pathway and abn..

Mutations of the PIK3CA Gene in Human Cancers

Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate signaling pathways important for neoplasia, including cell proliferation, adhesion, survival and motility. To determine if PI3Ks ..

4D Digital Rat Whole Body (ROBY) Phantom

The 4D digital rat whole body (ROBY) phantom is a realistic and flexible model of the rat anatomy and cardiac and respiratory motions for use in molecular imaging research. The organ shapes are model..

Single Cell Analysis of HIV Replication Capacity and Drug Resistance

This invention provides an assay to simultaneously analyze residual susceptibility and reduced replication capacity of drug-resistant viruses which may provide the ability to make more rational therap..

Alkenal/one Oxidoreductase (AOR) cDNA and Protein

Alkylating agents are useful compounds as anticancer drugs as they possess electrophilic characteristics that can promote cell death by covalently binding to cellular nucleophiles such as DNA and prot..

Novel Boronic Chalcone Derivatives and Uses Thereof

A class of anti-cancer agents such as chalcones has shown promising therapeutic efficacy for the management of human cancers. Recent studies have shown that anticancer agents such as chalcones induce..

4xwtCBF1-Luciferase and 4xmtCBF1-Luciferase Reporters

4xwtCBF1-Luc(pJH23A) is a luciferase reporter plasmid that contains 4 copies of a binding site for CBF1. It is a tool that provides readout for Notch signaling and for functional analysis of the Epste..

Forward Trafficking Motifs and their Uses

This technology demonstrates the existence of such dominant forward trafficking signal (FTS) motifs that can override an ER retention signal. Novel amino acid sequence motifs are been identified that ..

Vascular Barrier Protective Properties of Bioactive Components of Oxidized Phospholipids Released During Acute Injury Conditions

regain vascular integrity and to prevent edema formation. However, mediators that control restoration of endothelial barrier function are largely unknown. JHU researchers have discovered that oxidized..

R-3327-AT6.3

Highly metastatic prostate cancer cell line which will grow both in vitro and in vivo Description (Set) Proposed Use (Set) Technology may be used as a research reagent for prostate cancer resea..

Adeno-Associated Viral Gene Therapeutic For Cystic Fibrosis, TR5/2-CBA-(capital alpha)264CFTR

Cystic fibrosis (CF) is caused by a defect in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR protein regulates the conductance of sodium and chloride across cell membran..

JSC1

This primary effusion lymphoma (PEL) cell line was established from lymphomatous peritoneal effusion tumor cells that were anaplastic, large, and hematopoietic in appearance. The resultant cell line h..

WNT Pathway Antagonists

The Wnt signaling pathway is known for its important role in inductive interactions that regulate cellular growth and differentiation, and likely also plays important roles in the homeostatic maintena..

Hedgehog Pathway Antagonists

The Hedgehog pathway is known for its important role in inductive interactions that regulate growth and differentiation, and is likely also to play important roles in the homeostatic maintenance of p..

Hedgehog Pathway Antagonism for the Prevention and Treatment of Metastatic Prostate Cancer

Prostate cancer is the most commonly diagnosed malignancy in men in the United States. Although most prostate cancers are localized and grow too slowly to cause harm, an important minority develop the..

Use of NADPH-dependent alkenal/one oxidoreductase in the Bioactivation of Irofulven and Related Compounds that Preferentially Kill Cancer Cells

Irofulven (6-hydroxymethylacylfulvene, HMAF) is a novel anticancer chemotherapeutic that is under extensive clinical evaluation. It is an alkylating agent that is capable of forming DNA, RNA, and pro..

Antibody to Human DNA Methyltransferase 1

We successfully prepared a polyclonal rabbit antibody to a peptide derived from the N-terminus of human DNMT1 (the sub-contractor was provided with the peptide sequence, synthesized the peptide, inje..

Phosphodiesterase 5 Inhibition for Treatment of Cardiac Hypertrophy

Phosphodiesterase (PDE) enzymes are a family of proteins that degrade cyclic nucleotides; thus, playing a major role in cell signaling. PDE5a selectively catabolizes cyclic guanosine monophosphate (cG..

The BayesMendel Software Library for Predicting Inherited Genetic Susceptability to Cancer

A library of software tools to calculate the risk that an individual carries an inherited deleterious mutation of a known cancer gene. The calculation uses input from the individual?s family history ..

A Cell Line with Targeted Deletions of both Bax and p21

A Bax and p21 knock out cell line in human colorectal cancer cells. Details are described in the papers by Zhang et al. (2000) and Yu et al. (2003). Description (Set) Proposed Use (Set) Cells tha..

Cell Lines with Targeted Deletions of SMAD4

Creation of cell lines in which the SMAD4 genes have been disrupted by targeted homologous interation. Description (Set) Proposed Use (Set) Isogenic cell lines with or without intact SMAD4 genes..

hCNT3/PK15NTD

Cell line derived from swine kidney tubular epithelial cells which contains transfected human CNT3 as its only nucleoside transporter. Description (Set) Proposed Use (Set) Can be used to study ..

Polymerized Myoglobins as a blood Substitute

JHU researchers, in collaboration with other researchers, are developing artificial oxygen carriers to be used in therapeutics. Current artificial oxygen carrying technologies include the use of cell ..

Catheter and Method for Ablation of Atrial Tissue

The current invention is a novel catheter design that allows a wide ring of abalative lesion to be placed on the left atrial endocardial surface surrounding the pulmonary vein. The novel catheter diff..

Human Cancer Cell Lines Deficient in the CDC4 Gene

To assess the role of CDC4 in genetic instability, we generated cells that lack functional CDC4 genes. An abnormal chromosome number (aneuploidy) is a hallmark of human cancer, recognized for nearly a..

Human Cancer Cell Line Deficient in the BLM Gene

To assess the role of BLM in genetic instability, we generated cells that lack functional BLM genes. Genetic instability appears to be required for a normal colorectal epithelial cell to evolve into a..

A p105-based NF-(kappa) B Super repressor

Nuclear factor (NF)-kB is a family of transcription factors that regulate immune and inflammatory responses, programmed cell death (apoptosis), and developmental processes. In normal cells, NF-kB is l..

Pigment Epithelium-derived Factor as a Therapeutic Agent for Vascular Leakage, and a Peptide or Small Molecule Surrogate as Therapeutic Agent for Vascular Leakage and Neovascularization

Increased vascular leakage is a common feature of a number of disease states, including but not limited to, diabetic retinopathy, diabetic nephropathy, nephrotic syndrome, ascites, and rheumatoid arth..

Modulation of Insulin Secretion by Targeting a Novel Pancreatic Hyperpolarization-activated Current Via Pharmacological Intervention and/or Somatic Gene Transfer

An estimated 16 million people in the US alone suffer from diabetes, a disorder of glucose metabolism involving the hormone insulin. Indeed, diabetes is a leading cause of death. Conventional treatmen..

A Library of a Large Collection of Genotypically Defined Mutants

JHU researchers have generated a library of 1,183 genotypically defined Mycobacterium tuberculosis mutants using transposon-mediated random insertion mutagenesis. The transposon used to generate the ..

Transforming Single DNA Molecules into Fluorescent Magnetic Particles for Detection and Enumeration of Genetic Variation

Stat3 Antagonists and Their Uses as Vaccines Against Cancer

The present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing Stat3 ..

Bungarotoxin Binding Site (BBS)-tagging of Proteins

A novel approach to tag proteins using a minimal bungarotoxin binding site (BBS-tag). In this method we have developed a new method for the visualization of protein trafficking. We used a 13 amino aci..

Functionalized alpha 7 Nicotinic Receptor Ligands for Imaging

JHU researchers have synthesized a variety of new radiopharmaceuticals for imaging the a7 subtype of nicotinic cholingergic receptors. They are using nuclear medicine techniques, including positron em..

Method of Gene Transfer to the Cardiac Atria

Successful myocardial gene transfer remains an elusive target. Methods used to date include direct injection, pericardial effusion and intravascular administration. Transmural gene transfer has been ..

Method for Finding Mutations Caused by the Insertion of Repeated DNAs

Retrotransposons are very abundant mobile components of the human genome. They can move from one site to another in the genome. Retrotransposons move from place to place via an RNA intermediate and re..

hENT3/PS120

Cell line derived from swine kidney tubular epithelial cells which contains transfected human ENT3. Human ENT3 is a golgi nucleoside transporter. Description (Set) Proposed Use (Set) This cell ..

hENT2/PK15NTD

Cell line derived from swine kidney tubular epithelial cells which contains transfected human ENT2 as its only nucleoside transporter. Description (Set) Proposed Use (Set) Can be used to study t..

hENT1/PK15NTD

Cell line derived from swine kidney tubular epithelial cells which contains transfected human ENT1 as its only nucleoside transporter. Description (Set) Proposed Use (Set) Can be used to study t..

Minimally Invasive Surgical Assistance System for Throat Surgery

Minimally Invasive Surgery (MIS) is a surgical approach aiming at reducing the healing time and trauma to the patient as a result of performing surgery on internal organs. In this approach, the treate..

PK15NTD Cells

Cell line derived from swine kidney tubular epithelial cells which are deficient in endogenous nucleoside transporters. Description (Set) Proposed Use (Set) Pharmacological tool for evaluation o..

Method for Treating Nausea and Vomiting of Pregnancy

We have developed a new method to treat nausea and vomiting by stimulation vagus nerve fibers in the neck using electrodes attached to a current source. We can also stimulate the vagus nerve fibers us..

Spinal Vertebral Interventions by Natural Orifice Translumenal Endoscopic Surgery (NOTES)

Abstract Vertebral spine procedures are currently performed via thoracoscopy and other percutaneous approaches. With the advent of natural orifice translumenal endoscopic surgery (NOTES) techniques,..

Hybridoma RG-1

tract JHU scientists generated a monoclonal antibody, RG-1, that binds to highly conserved L2 residues and neutralizes human papillomavirus 16 (HPV16) and HPV18. Passive immunotherapy with RG-1 was ..

Yeast Knockout Mutation (YKO) Collections and Yeast Double Knockout Collections

JHU researchers have produced collections of single and double yeast knockout (YKO) mutants. Description (Set) Proposed Use (Set) Collections of YKO mutants are useful for determining the functi..

Inhibitors of Beta Lactamase

The invention provides novel non-.beta.-lactam inhibitors of .beta.-lactamases. In particular, the invention provides boronic acid-based compounds set forth in the specification. These compounds may b..

Suppression of HIV Replication and Prevention/Treatment of HIV-Associated Dementia by Minocycline

This invention describes the addition of a tetracycline derviative to existing combinations of antiretroviral drugs for treatment of HIV-infected individuals. JHU researchers have determined that the ..

Antitumor Effects Generated by pNGVL4a-Sig/E7 (detox)/HSP70 DNA Vaccine Administered Through Gene Gun, Biojector and Syringe

DNA vaccines have emerged as an attractive approach for antigen-specific cancer immunotherapy. We have previously linked Mycobacterium tuberculosis heat shock protein 70 (HSP70) to human papillomaviru..

Isogenic Cell Lines with or without Intact BAX Genes

To assess the role of BAX in drug-induced apoptosis in human colorectal cancer cells, we generated cells that lack functional BAX genes. Such cells were partially resistant to the apoptotic effects o..

A Defective Response to Hedgehog Signaling In Disorders of Cholesterol Biosynthesis

This invention provides a method to stimulate stem or progenitor cells with a signaling molecule in vitro and produce a uniform population of the desired differentiated cell type. For example, with th..

Synthetic mammalian retrotransposon gene

Retrotransposons are infectious pieces of DNA that can insert themselves (a process referred to as retrotransposition) into the genomes of their hosts, which include all mammals, such as human beings...

Anthracycline doxorubicin-resistant carbonyl reductase-1 knock out mice

The cancer treatment drug doxorubicin (brand name adriamycin) is very effective against tumors, but causes a serious side effect of heart damage. This toxicity occurs in part because the enzyme carbon..

Use of Hedgehog Pathway Inhibitors in Small Cell Lung Cancer

We have shown that small cell lung cancer (SCLC), a highly aggressive and frequently lethal tumor, uses an embryonic signaling pathway to promote its growth. This signaling pathway is known as the Hed..

Method for producing diverse libraries of encoded polymers

With our reagents, libraries of drug-like molecules are rendered in a format where they can be subjected to evolution. This enables processing of libraries that are about 10 orders of magnitude more ..

Cell Lines Expressing APC in Inducible Manner

JHU scientists have created an inducible expression system for APC in HT-29 colorectal carcinoma cells. Using this novel inducible expression system, it was shown that APC inhibits cell growth throug..

p21 Knock Out Human Mammary Epithelial Cell Lines

MCF-I0A human breast epithelial cell lines devoid of the p21 gene. Description (Set) Proposed Use (Set) These cell lines could be used to screen for drugs that target the p21 pathway and/or the ..

Transcriptome of Human Hematopoietic Stem Cells

The human CD34+/CD38-/Lin- cell subset comprises ~1-10% of the CD34+ cell population and includes few of the less primitive hematopoietic (lineage-committed) progenitor cells (HPCs), yet contains most..

Eight Anti-ganglioside Monoclonal Antibodies

Monoclonal antibodies to major brain cell surface antigens involved in axon-myelin stability, nerve regeneration, and control of nerve cell signaling. Description (Set) Proposed Use (Set) Diagn..

Comparison of HPV DNA Vaccines Employing Intracellular Targeting Strategies

Human papillomavirus (HPV) E6 and E7 are consistently expressed and are responsible for the malignant transformation of HPV-associated lesions. Thus, E6 and E7 represent ideal targets for therapeutic..

Rat 1a-myc

Rat 1a-myc is a human MYC oncogene transformed Rat 1a fibroblast cell line. Description (Set) Proposed Use (Set) This cell line is an ideal tool to study Myc function and transforming activity. ..

Digital Karyotyping

Alterations in the genetic content of a cell underlie many human diseases, including cancers. A method called Digital Karyotyping provides quantitative analysis of DNA copy number at high resolution. ..

Inhibition of Hedgehog Signaling by Direct Binding of Cyclopamine to Smoothened (Efficient Drug Screening for Thousands of Protein Targets)

Opportunity I: Dysregulation of the Sonic hedgehog-Patched-Gli pathway leads to several human diseases. Disruptions in this pathway during embryogenesis are associated with birth defects. In adults, a..

Use of Antibiotic Minocycline in Viral Diseases of the Central nervous System

Diseases associated with West Nile Virus (WNV) and other encephalitis viruses are increasingly common. Plus, currently no treatment exists for any of the encephalitis viruses. WNV alone has become a ..

Novel Tyrosine Kinases Implicated in Colorectal Cancers

Tyrosine kinases (TK) are the regulators of signaling pathways that control cellular functions such as differentiation, transcription, cell cycle progression, and apoptosis. Tyrosine kinases are somet..

PUMA Mediates the Apoptotic Response to p53

The p53 pathway is inactivated in the great majority of human cancers. Of the many physiologic effects of p53 that have been described, current evidence suggests that apoptosis is critical for its tum..

Isogenic Cell Lines Deficient in DNA Methyltransferase Genes

Cell lines with disruptions of various DNA methyltransferase genes have been created. Description (Set) Proposed Use (Set) Useful for screens to identify drugs that can inhibit the growth of can..

Disulfide Constrained Peptides for Targeting the Prostate Specific Membrane Antigen

Utilizing a standard phage display methodology, we have screened a hepta-peptide disulfide bridge constrained phage display library for binding to the prostate specific membrane antigen (PSMA). PSMA i..

Design and Synthesis of Renal Dipeptidase Inhibitors

Colon cancer is a deadly disease with a 6% average lifetime risk in the United States. When detected in the earliest stages, patients have a 90% survival rate. In the early stages of colon cancer, how..

A Molecular Mechanism for Action of Immunophilins and a Method to Identify Novel Pharmaceuticals

The immunophilins are a family of proteins that are functionally related by their rotamase activity (ie they are peptidylprolyl isomerases, PPIase) and their ability to bind immunosuppressive drugs su..

Polyamine Analogues With Significant Antitumor and Antiparasitic Activity

Johns Hopkins researchers have synthesized a novel series of terminally alkylated polyamines that have significant biological activity. Some of the analogues have impressive antitumor activity against..

Boronic-Chalcone Analogs as MDM2 Inhibitor

A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human breast cancer cell lines. The results show the boronic-chalcones are more toxic to breast canc..

Boronic-Chalcone Analogs as MDM2 Inhibitor

Enhancement of Adenoviral Oncolytic Activity by Modification of the E1A Gene Product

The present invention relates to compositions and methods for enhancing the oncolytic activity of replication-competent, target cell-specific adenovirus vectors by modification of the E1A gene product..

Generation of HLA-Ig based Artificial Antigen Presenting Cells

Adoptive immunotherapy involves stimulation of viral- or tumor-specific T cells, ex vivo, followed by transfer of expanded numbers of activated autologous T cells back into patients. While adoptive im..

Expanding Human Embryonic Stem Cells Using human Adult (Marrow) Cells or Derived Molecules

All the existing human embryonic stem cells (hESCs) are derived and propagated on mouse embryonic fibroblasts (MEFs). We established a method to derive and expand human cells (from adults) that can fu..

Hypoxia-induced Mitogenic Factor

JHU researchers have discovered a novel cytokine named Hypoxia- Induced Mitogenic Factor (HIMF; also known as FIZZ1/RELM? a secreted protein that is highly up regulated in the lungs as a result of hyp..

Cell Lines For Evaluation of 'Beta'-Catenin Function

Mutation in the beta-catenin/APC pathway are responsible for over 90% of all colon cancers in humans. Mutations in the beta-catenin gene activate the activity of this oncogene and cause uncontrolled g..

Modulators of hedgehog Signaling

Members of the Hegdehog (Hh) family of secreted signaling proteins play critical roles in coordinating cell growth and differentiation. Impaired pathway function in embryogenesis can produce severe ma..

Tracker Robot For CT-Guided Interventions

A new robotic system for CT-guided operations has been developed to perform precise manipulation of a needle or other surgical instrument in the confined space of the imager without interfering with t..

Specific Ablation of STAT3(beta) Distorts the Pattern of STAT3-Responsive Gene Expression and Impairs Recovery From Endotoxic Shock

Stat3 is one of seven mammalian signal transducer and activator of transcription molecules that are activated by the Janus Kinases in response to cytokines. Although originally identified as an acute-..

Mutations in Macrophage Scavenger Receptor 1 Gene Increase Risk of Prostate Cancer, Asthma, and Cardiovascular Disease

The present invention discloses methods of screening a subject for increased likelihood or risk of certain diseases or disorders. This method comprises detecting the presence or absence of at least on..

pNB1 + pNB3

These molecular biology research tools are recombinant yeast plasmids that were designed for use with an in vitro Tn7 transposition system Description (Set) Proposed Use (Set) Genome analysis, ch..

Simulation System for Training and Pre-treatment Planning of Image Guided Needle Placement Proceedures for Vertebroplasty and Other Orthopedic and Soft Tissue Diagnostic & Therapeutic Medical Applicat

The invention is designed to provide physicians and paramedical medical personnel with a simulation system that will allow them to train, practice and or pre-plan image guided needle placement procedu..

Non-invasive Diagnostic Imaging Technology For Mitochondria Dysfunction In Man By Using Lipophilic Cations Labeled With F-18 and I-123

In the last decade a new field of ?Mitochondrial Medicine? has been created from the discovery that a wide array of diseases in humans are associated with mitochondrial dysfunction. A partial list of ..

Claudins As markers For Early Detection, Diagnosis, Prognosis and as Targets of Therapy For breast Cancer

We have recently identified Claudins 1, 3, 4, and 7 as differentially expressed in breast cancer relative to normal breast tissue. Further studies have shown Claudins 1 and 7 to be down-regulated in p..

1. A Family of Novel Flavoenzymes, 151, that Binds Actin and Regulates Repulsive Axon Guidance Through Oxidation-Reduction Mechanisms and 2. A Role For Oxdidation of Actin In Limiting Axonal Outgrowth

We have identified a class of proteins containing members which directly binds to the cytoplasmic domains of plexin receptors in both invertebrates and vertebrates, and we have shown that these protei..

Enhancing DNA Potency By Co-administration of DNA Encoding Anti-apoptotic Proteins

Intradermal vaccination via gene gun efficiently delivers DNA vaccines into dendritic cells (DCs) of the skin, resulting in activation and priming of antigen-specific T cells in vivo. However, DCs hav..

In Vitro and In Vivo Induction of Potent Bystander Anti-Tumor Effects Through Inhibition of Stat3 Signaling

The present invention relates to methods for modulating, i.e., agonizing or antagonizing, Stat3 (Signal Transducer and Activator of Transcription3) signaling activity for use in gene therapy. Inhibiti..

Cell Line 2V6.11

Abstract (Set) The human adenovirus E4 ORF 6 34 kDa oncoprotein (E4 34k), in concert with the 55 kDa product of E1b, prevents concatenation of viral genomes in infected cells, inhibits the repair of ..

Software Tools for Analysis of Chromosomal Abnormalities in Pedigrees Using High Density Genomic Data SNPtrio

Abstract (Set) Description (Set) Chromosomal DNA alterations can be detected using high density single nucleotide polymorphism (SNP) microarrays. These include deletions and duplications (assessed..

Three Software Tools for Analysis of Chromosomal Abnormalities in High Density Genomic Data

Abstract (Set) High density single nucleotide polymorphism (SNP) data have been used to identify chromosomal changes in DNA samples. A current challenge is to identify disease associated changes such..

Software Tools for Analysis of Chromosomal Abnormalities in Pedigrees Using High Density Genomic Data.

Description (Set) The SNP software analysis tools use a novel "reverse pedigree" method to detect genetic differences between siblings. This reversed pedigree method reveals how regions of chromosome..

Anopheles Gambiae Densonucleosis Virus Expression System

Abstract (Set) Densonucleosis viruses (DNVs) are single-stranded non-enveloped viruses in the family parvoviridae. This invention is the novel Anopheles gambiae densonucleosis virus (AgDNV), and the ..

A New In Vitro Assay For Evaluating Anti-viral Drug Activity

Abstract (Set) JHU scientists have developed an efficient in vitro single-round virus infectivity assay with a high correlation to clinical outcomes of drug treatment. This reporter virus assay is an..

Prevention and Treatment of Bacterial and Fungal Meningitis

Description (Set) Johns Hopkins University is currently seeking licensees for a method of preventing meningitis caused by bacterial or fungal infection. Meningitis is a serious and often deadly infla..

The New Culture Method of Rat Distal Pulmonary Vein Smooth Muscle Cell

Description (Set) Isolation of primary cell populations is complex and requires a significant amount of technical expertise to produce purified and viable cultures. JHU scientists have developed an o..

Treatment of Retinal Degenerations with Gene Transfer of Components of the Anti-oxident Defense System

Abstract (Set) In age-related macular degeneration (AMD), rods, cones, and retinal pigmented epithelial (RPE) cells die from oxidative damage. JHU scientists have determined that increased expression..

miRNA Microarray Analysis in Barrett's Esophagus and Esophageal Adenocarcinoma

Description (Set) JHU scientists have discovered independent microRNA specific for Barrett?s esophagus (BE) and Esophageal adenocarcinoma (EAC). These EAC and BE microRNA could be used as diagnostic ..

Methods of Generating Primate Pluripotent Stem Cells from Non-Embryonic Sources

Abstract (Set) Currently, the efficiency of generating human induced pluripotent stem (iPS) cells is low. JHU scientists have found a way to improve it by supplementing an additional gene or bioactiv..

Prostate Cancer Cells Derived from Familial Prostate Cancer Tumor and Methods of Use

A cell line has been generated from a culture of prostate epithelial cells taken from a prostate cancer patient with a strong family history of prostate cancer. This is the first cell line to be gener..

Screening Method to Predict Donor Organ Function after Transplantation

Abstract (Set) Transplantation represents an established procedure in end-stage organ failure patients and results in satisfying long-term results. However, this surgical therapy is continuously limi..

Improved Method of Human Embryonic Stem Cell Embryoid Body Formation

Description (Set) JHU scientists have developed an optimized method for culturing and differentiating human embryonic stem (hES) cells. Obtaining sufficient numbers of viable differentiated cells fro..

Diagnostic Biomarkers of Kidney Transplant Dysfunction

Abstract (Set) Johns Hopkins University is currently seeking licensees for a panel of biomarkers for kidney transplant dysfunction. Kidneys are the most frequently transplanted organ in the U.S. Kidn..

J HIN, J RASSF1A, J TWIST, J HIC Plasmids

Abstract (Set) Plasmid DNAs incorporating human gene-specific promoter sequences altered by sodium bisulfate treatment. The plasmids contain sequences hybridizing to external QM-MSP regions within ge..

Johns Hopkins Approved Wireless Portable Polysomnography Monitoring Device

Abstract (Set) Currently there are no clinically proven portable devices that objectively measure and record sleep activity in a reliable fashion at minimal inconvenience to the patient. While portab..

Selective Prodrug Activation in Cancer Cells Using Protein Switches

Cancer is a major health problem in the world and is the second leading cause of death in the U.S. An estimated 1.3 million new cases of cancer are reported in the U.S. each year. Current chemotherape..

Plasmid pProEX-hOtu1

Abstract (Set) The plasmid pProEX-hotu1 was constructed using vector pProEX and cDNA of human otubain 1. The plasmid was created for expression and purification of recombinant human otubain 1 in E.co..

Known Drug found to have applicability in the area of glaucoma, optic nerve diseases, and other neurodegenerations

Abstract (Set) According to the World Health Organization, glaucoma is the second leading cause of blindness in the world. One approach to treat glaucoma, and optic nerve diseases as well as other ne..

Floating Chamber Set for Multi-Well Tissue Culture Plate

Abstract (Set) Description (Set) Clear, precise immunohistochemistry data is reliant on the quality of immunolabeling and the structural integrity of the tissue being examined. Most tissue process..

Glutaminase Inhibition to Treat Cancer, Cardiac Ischemia and Stoke

Abstract (Set) A common occurrence in cancer is altered glucose metabolism where cells take up glucose avidly and convert it primarily to lactate, despite available oxygen. These cells also depend on..

Collagen Mimetic Peptides for Imaging and Therapy

Abstract (Set) Collagens, the most abundant protein in mammals, provide a structural framework during tissue development and repair. Functionalized collagen that incorporates exogenous compounds may ..

DLD-Chk1 S317A Cells

Abstract (Set) Chk1 kinase acts downstream of ATM/ATR kinase and plays an important role in DNA damage checkpoint control, embryonic development and tumor suppression. JHU scientists have engineered ..

A Malaria Vaccine to Stop Malaria Transmission

Abstract (Set) Malaria is a disease caused by parasites of the genus Plasmodium. It affects near 2 billion people worldwide and results in 1-2 million deaths every year. Transmission-blocking vaccine..

COA360.org - Cultural Competency Organizational Assessment

Abstract (Set) Today, four states in U.S. are minority-majorities (California, Texas, New Mexico, and Hawaii) and by 2010 there could be as many as eight. Nearly 18% of Americans speak a language oth..

JH-EsoAd1- Esophageal Cancer Cell Line

Abstract (Set) Esophageal adenocarcinoma currently has one of the most rapidly increasing tumor incidences in the United States, with the vast majority of cases occurring on the backdrop of metaplast..

Rabbit Serum 2804: Antibodies Against Human LAP2

Abstract (Set) Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate filaments (lamins) and membrane associated proteins called lamin-associated ..

Rabbit Serum 2805: Antibodies Against Human LAP2

Rabbit Serum 2807: Antibodies Against Xenopus LAP2

Rabbit Serum 2999: Antibodies Against Human Emerin

Rabbit Serum 3273: Antibodies Against Human BAF

Rabbit Serum 4278: Antibodies Against Human MAN1

Rat Serum 4279: Antibodies Against Human MAN1

Rabbit Serum 5045: Antibodies Against Human BAF`

Rabbit Serum 5688: Antibodies Against Rat Lmo7

Rabbit Serum 5690: Antibodies Against Rat Lmo7

Targeting CD4+ Cells to Treat Ischemia Reperfusion Injury

There is currently no specific therapy for ischemic acute renal failure. We have recently identified that CD4+ T cells directly participate in the pathogenesis of the injury. Furthermore, modulating C..

Carcinogen-specific Induction of Genetic Instability

The researchers created two H3 colorectal cancer cell lines. One cell line has chromosomal instability (CIN) and resistance to 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP). The other cell l..

Disruption of p53 in Human Cancer Cells Alters the Responses to Therapeutic Agents

p53 knockout in human colorectal cancer cell line HCT116. Details are described in the paper by Bunz et al., 1999 Description (Set) Proposed Use (Set) The p53 gene is inactivated in the majority ..

14-3-3sigma is Required to Prevent Mitotic Catastrophe After DNA Damage

14-3-3Sigma knockout in human colorectal cancer cell line HCT116. Details are described in the paper by Chan et al., 1999 Description (Set) Proposed Use (Set) 14-3-3Sigma promotes pre-mitotic cel..

Association of Dopamine Beta-Hydroxylase Polymorphisms with Bipolar Disorder

A central role for the gene encoding dopamine beta-hydroxylase in neuropsychiatric disorders is disclosed. Use of single nucleotide polymorphisms in the dopamine beta-hydroxylase gene for diagnosis, p..

Inhibition of Retroelement Replication With Divalent Cations

AIDS is a devastating disease caused by the HIV-1 virus. Happily, there are now highly active antiviral drug cocktails available that allow many patients to control the disease. Nevertheless, many pat..

Enhancement of DNA Vaccine Potency by Linking Marek's Disease Virus Type 1 VP22 to an Antigen

We have previously employed an intercellular spreading strategy using herpes simplex virus type 1 (HSV-1) VP22 protein to enhance DNA vaccine potency because DNA vaccines lack the intrinsic ability to..

Use of Isogenic Human Cancer Cells for High-throughput Screening and Drug Discovery

A novel high-throughput drug screening strategy is described using isogenic human cancer cell lines that are genetically identical except for the presence or absence of a key cancer causing gene. Isog..

Macaca Mulatta CCR8 cDNA

Both simian and human immunodeficiency viruses (SIV and HIV) utilize chemokine receptors with or without CD4, as portals for entry into susceptible cells. JHU researchers have cloned 11 rhesus macaque..

Use of Proaerolysin Toxins Modified to Contain Tissue Specific Protease Activation Sequences as Targeted Therapy For Cancer

Proaerolysin is a bacterial toxin that is normally activated by furin protease to produce the pore forming toxin aerolysin which is toxic to prostate cancer cells at picomolar concentrations. We have ..

Beta-Secretase (BACE1) Knockout Fibroblast Cells

We have developed BACE1 knockout cells to further facilitate our understanding of physiological consequences of the lack of BACE1 in cells. We have established BACE1 knockout immortalized cell lines b..

Identification of P53-activating Compounds for Cancer Research and Therapy

An exciting,new invention from the laboratory of Dr. Scott Kern at The Johns Hopkins University School of Medicine for the identification of p53 activating compounds that I thought would be of interes..

Modulation of systemic Immune Responses by Transplantation of Hemotopoietic Stem Cells Transduced with Genes Encoding Antigens and Antigen Presenting Cell Regulatory Molecules

The initiation of T cell-dependent immune responses depends on presentation of antigens by bone marrow-derived antigen-presenting cells such as dendritic cells. Tolerance induction depends on expressi..

R-3327 AT.2

AT-2 originates from the spontaneous tumor (R3327) of the prostate identified by W.F. Dunning in a 22 month-old inbred Copenhagen male rat (1961). R3327 has been maintained by continuous serial passag..

R-3327 MAT-LyLu

This cell line was derived from the "H" subline and upon passage to the AT-1 subline (JHU-29) of the parental R3327 tumor The "H" subline is a heterogeneous cell line as it is comprised of androgen-de..

R-3327-MAT-Lu

This cell line was derived from the "H" subline and upon passage to the AT-1 subline (JHU-29) of the parental R3327 tumor. The "H" subline is a heterogeneous cell line as it is comprised of androgen-d..

R-3327 G

The in vitro cell line R-3327-G was derived from the parental R3327 tumor discovered by W.F. Dunning in a 22-month-old inbred Copenhagen male rat. Upon several in vivo passages of the original tumor, ..

R-3327-3.1

AT-3 originates from the spontaneous tumor (R3327) of the prostate identified by W.F. Dunning in a 22 month-old inbred Copenhagen male rat (1961). R3327 has been maintained by continuous serial passag..

R-3327-AT-1 (Rat Prostatic Cancer Cell Line)

AT-1 originates from the spontaneous tumor (R3327) of the prostate identified by W.F. Dunning in a 22 month-old inbred Copenhagen male rat (1961). R3327 has been maintained by continuous serial passag..

R-3327-AT6.1

Somatic cell hybrids created from highly metastatic rat prostatic cancer cells and human chromosome 11 were created using micro cell-mediated chromosome transfer. The introduction of human chromosome..

MoPrP. Xho Vector

This plasmid expression vector was developed to direct the expression of foreign genes in the brains of transgenic mice. The vector, which is transcriptionally dependent on the mouse prion protein pro..

Fas Ligand-Expressing Hematopoietic Cells for Transplantation

Rejection of allografts is mediated by activated T cells that recognize alloantigen presented by dendritic and other antigen presenting cells. To decrease the immune response against allografts, Johns..

Genetic Disruption of PPAR(delta) Decreases Tumorigenicity of Human Colon Cancer Cells

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are involved in many normal and disease related processes, such as lipid metabolism and cancer. Specifically, iso..

Oncogenic Osteomalacia-Related Gene 1: MEPE

This invention provides isolated polynucleotides encoding an oncogenic osteomalacia-related factor and polypeptides encoded by this polynucleotide. Expression systems, including gene delivery vehicles..

Phosphatonin-Related Gene: FRP - 4

This invention provides methods for modulating phosphate homeostasis and renal phosphate transport by delivering agents that alter the expression of the FRP-4 gene or alter the activity of the FRP-4 p..

Enhancement of Suicidal DNA Vaccine Potency by Linkage Mycobacterium Tuberculosis Heat Shock Protein 70 to an Antigen

Naked DNA vaccines represent an attractive approach for generating antigen-specific immunity because of their stability and simplicity of delivery. There are particular concerns, however, such as pote..

Cancer Immunotherapy using a DNA Vaccine Encoding the Translocation Domain of a Bacterial Toxin Linked to a Tumor Antigen

DNA vaccines are an attractive approach for tumor immunotherapy. One concern about DNA vaccines is their potency since they do not amplify themselves. Domain II of Pseudomanas Exotoxin A (ETA(dII))has..

Methods for Identifying Gene Regulatory Sequences, and the Identity of such Sequences

A barrier to advances in understanding the mechanisms and regulation of imprinting of a genomic region is our poor understanding of the organization of genes and the cis regulatory factors located in ..

Beta - Secretase (BACE1) Knockout Mice

Two beta-secretases termed BACE1 and BACE2 have been shown to generate the Alzheimer's disease Abeta peptides. To examine the physiological roles of BACE1 and to determine whether BACE1 is the major b..

Practical Tunable Planar and Cylindrical Multi-element Magnetic Resonance Detector Arrays

The invention is a detector for MRI signals, and is used in conjunction with an MRI scanner. More specifically, the invention is a tunable strip array for providing multi-channel detection of MRI sign..

CTD110.6 monoclonal antibody

O-linked N-acetylglucosamine (O-GlcNAc) is a newly described but ubiquitous dynamic modification of key regulatory proteins in side virtually all multi-cellular eukaryotic cells. Recently, this sugar ..

Determinants of ShhN required for signaling

The invention relates to hedgehog proteins that are involved in signaling developmental processes. The proteins of the invention modulate differentiation of neural plate. Also provided are methods for..

Use of Fluorescence Resonance Energy Transfer to Directly Monitor the Receptor-Mediated Activation of Heterotrimeric G-proteins in Living Cells

Techniques to visualize heterotrimeric G-protein signaling in cells has not proven effective thus far. The best technique to date, calcium imaging, requires cells to be loaded with a fluorescent calci..

PICK1 Antibody and GluR2 Phospho-specific Antibody

Antibodies to analyze the levels of the PICK1 protein and the phosphorylation of Ser880 of the AMPA receptor GluR2 subunit. Description (Set) Proposed Use (Set) PICK1 has been shown to regulate ..

Neuroprotection and Inhibition of Apoptosis by Mitrochondrial Potassium Channel Openers

Mitochondria can either enhance or suppress cell death. Cytochrome C release triggers apoptosis, but activation of mitochondrial ATP-sensitive potassium (mitoPotassiumATP) channels prevents lethal isc..

Prevention and/or Treatment of Neurodegenerative Diseases by Elevation of Glutathione and Phase Detoxification Enzymes

A wealth of data has unambiguously showed that cellular glutathione (GSH) protects neurons against degeneration (possibly by preventing apoptosis). Phase 2 enzymes such as GSH transferase that also he..

Recombinant Ehrlichia Phagocytophila Major Surface Protein (MSP) From Clone p20H13

Recombinant E. phagocytophilia MSP is a major immunodominant protein antigen derived from the human E. phagocytophilia (HE agent) strain BDS. The clone was initially selected based upon reactivity wit..

A Single Image Registration Method for Image Guided Interventions

The purpose of this invention is to determine the three-dimensional position and orientation of an effector (a needle, probe, etc.) relative to a subject using single cross sectional images (e.g. from..

Enhancement of Nucleic Acid Vaccine Potency by Intercellular Spreading and Enhancement of MHC Class I Presentation of Antigen Linked to Herpesvirus VP22 Protein

The potency of naked DNA vaccines is limited by their inability to amplify and spread in vivo. VP22, a herpes simplex virus type 1 (HSV-1) protein, has demonstrated the remarkable property of interce..

Application of Photochemotherapy for the Treatment of Cardiac Arrhythmias

Atrial fibrillation (very rapid random heartbeats) is the most common and debilitating electrical abnormality of the heart that affects nearly 2 million Americans and is responsible for 150,000 stroke..

CAIN Antibody

A novel protein which is a calcineurin inhibitor (CAIN) has been identified, cloned, and characterized. Description (Set) Proposed Use (Set) Calcineurin is a widely distributed protein phosphata..

LuSIV Cells: A Highly Sensitive Detection System for Infectious HIV and Related Retroviruses

JHU researchers constructed a reporter cell line, derived from human CEMx174 cells, that can be used to readily identify cells that are infected with HIV and related retroviruses. This cell line, desi..

Establishing Genomic Imprinting by Cell Differentiation: A Model System Using Embryonic Germ Cells

The purpose of the invention is to develop the first in vitro model system for studying genomic imprinting. This model system is based upon the development of pluripotent embryonic germ (EG) cells tha..

The Analgesic and Anesthetic Effects of Inhibiting the Interaction of the NMDA Receptor Subunits 2A/2B with Neuronal Nitric Oxide via PDZ Domain of PSD95/SAP90

PSD-95/SAP90 is a molecular scaffold protein that, through interactions involving its PDZ domains, couples the NMDA receptor to cellular signaling pathways at neuronal synapses. PSD-95/SAP90?s mRNA an..

Rapid PCR-based blood test for Detection of Bacteria

An innovative technique that establishes a unique and highly specific assay, which eliminates ubiquitous background DNA in all PCR reagents (Taq polymerase, primers, dNTP's, PCR buffer, MgC12) by empl..

Enhancement of Sindbis Virus Self-Replicating RNA Vaccine Potency by Linkage of Mycobacterium Tuberculosis Heat Shock Protein 70 Gene to an Antigen Gene

Self-replicating RNA vaccines (RNA replicons) have emerged as an effective strategy for nucleic acid vaccine development. Unlike naked DNA vaccines, RNA replicons eventually cause lysis of transfected..

GDF-1 Knockout Mouse

Transgenic knockout mouse serves as a useful tool to identify the developmental activity associated with the expression of the growth/differentiation protein, GDF-1. Description (Set) Proposed Us..

Enhancement of DNA Vaccine Potency by Linkage of Antigen Gene to the Extracellular Domain of FLT3-Ligand Gene

professional antigen presenting cells (APCs), particularly dendritic cells (DCs). A recombinant chimera of the extracellular domain of Flt3-ligand (FL) linked to a model antigen may potentially target..

Monoclonal Antibodies to Gangliosides Raised in Ganglioside-Deficient Knockout Mice

Knock-out mice lacking complex gangliosides were found to be improved hosts for raising high affinity, high titer monoclonal IgG anti-ganglioside antibodies. Gangliosides are major cell surface determ..

Fusion of Calreticulun (CRT) to Antigens Enhances the Potency of DNA Vaccines

Antigen-specific cancer immunotherapy and anti-angiogenesis have emerged as two attractive strategies for cancer treatment. An innovative approach that combines both mechanisms will likely generate th..

Novel Strategy to Enhance the DNA Vaccine Potency

Nucleic acid vaccines represent an attractive approach to generating antigen-specific immunity because of their stability and simplicity of delivery. However, there is still a need to increase the pot..

Method to Assess Vascular Endothelial Function using Phase-Contrast Magnetic Resonance Angiography

Endothelial function is crucial in maintaining cardiovascular health. FMD is a noninvasive method of evaluating endothelial function. Impaired FMD measured by ultrasound correlates with cardiovascular..

The Analgesic and Anesthetic Roles of CGMP-Dependent Protein Kinase Ia Inhibitor

IA selective, potent and cell-permeable inhibitor of cGMP-dependent protein kinase Ia, without effects on cAMP-dependent protein kinase or cGMP-regulated phosphodiesterases, has been found to reduce ..

Facilitation of the Expression in Eukaryotic Cells of Exogenous Genes by an Exogenous Compound

Scriptaid is a histone deacetylase inhibitor that provides a simple means of increasing the efficiency of plasmid-based reporter and expression constructs. When added to mammalian cells in culture Scr..

A Visual Color Detection System to Identify Agents that Induce Mitochondrial Dysfunction.

Mitochondrial dysfunction can lead to many diseases and can effect any organ at any age. The number of diseases associated with mitochondrial dysfunction has grown tremendously within the past decade ..

Techniques Using Heat Flow Management, Stimulation, and Signal Analysis to Treat Medical Disorders

This invention pertains to methods of treating a brain disorder using heat transfer, electrical stimulation, or delivery of medication so as to stop or prevent seizures or to improve function of the b..

Genetic Engineering of Autologous Vein Grafts with thrombomodulin-Expressing Vectors to Resist thrombosis, Neointimal Hyperplasia and Atherosclerosis

Autologous vein grafts are the most widely used conduits for coronary and peripheral arterial bypass surgery. Compared to arterial grafts, vein grafts suffer significantly higher failure rates that li..

Fusion of Heat Shock Protein 70 to Antigens Enhances the Potency of DNA Vaccines

Increasing evidence has suggested that CD8+ T cell mediated immune responses are important in controlling both intracellular pathogens and tumors. Using human papillomavirus E7 as a model antigen, we ..

Rapid Chest Tube Inserter

Key issues for chest tube insertion include location, penetration angle, control of depth of insertion (to minimize the risk of injury to internal structures), and effective evacuation of air/blood fr..

Mass-Correlated Pulsed Extraction for a Time-of-Flight Mass Spectrometer

This method and apparatus provides improved focusing and mass resolution over a broad mass range for a time-of-flight mass spectrometer. This is accomplished in a two-source extraction scheme in which..

Intraventricular Injection of Urokinase or other Thrombolytics

An experimental therapy that could accelerate the resolution of the blood clot and thus reduce the clot-related pathological events associated with the clinical management of intraventricular hemorrha..

Synphilin-1, a Protein which Associates with Alpha-Synuclein and Promotes the Formation of Cytostolic Inclusions

Complementary DNA encoding the neural protein ?synphilin-1? was cloned via the protein?s interaction with synuclein, a previously identified product which has been genetically linked to Parkinson?s Di..

Narp is a Synaptogenic Factor for Excitatory Glutamate Receptors

A novel neuronal cell growth factor, neuronal-activity regulated pentraxin or NARP and its encoding cDNA sequence is provided in this invention. Narp induces dendritic neurite outgrowth, promotes neur..

Biodegradable and Biocompatible Lactide-Phosphate Copolymers, Compositions, Articles and Methods for Making the Same

The growing need for new polymer-based drug delivery materials continues to stimulate polymer research. Although several classes of synthetic polymers have been studied for controlled drug delivery an..

Phenylalkenoic Acid-Mediated Corection of Aberant Protein Trafficking

This discovery encompasses the compound 4-phenyl-delta3-transbutenoic acid, which restores normal biosynthetic trafficking to the CFTR mutation deltaF508 The mechanism centers on butyrate-mediated dow..

Immunotherapy of Autoimmune Disease by co-transfection of Antigen Presenting Cells

Immunologic tolerance to self antigens is a necessary mechanism for protecting an organism from destruction by its own immune system. A number of diseases such as Multiple Sclerosis, Lupis, Myathenia ..

Homer Regulates Cellular Calcium Signaling: A Novel Target for Pharmaceutical Development

A method is provided for identifying a compound that modulates a cellular response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for i..

Neutralization of HIV-1 by Bacterial Toxins

Aerolysin is a channel-forming toxin secreted by Aeromonas spp. that binds to glycosyl phosphatidylinositol (GPI)-anchored proteins, such as Thy-1, on sensitive target cells. Receptor binding is follo..

Antisera to Pax-6 Protein

A rabbit polyclonal antisera which recognizes the developmentally important protein marker, Pax-6, in both histological sections and cultured cells. The localized protein identifies neuronal progenito..

Biosynthetic Engineering of Cell Surface Sialic Acids

Surrounding every cell is a halo of glycoproteins, glycolipids and proteoglycans termed the glycocalyx. On these structures, the most common terminus is the sugar sialic acid which is unique in its 9-..

TC-1 (Po)

This cell line "was developed to circumvent the confounding issue of negatively selecting nonessential tumor markers in cancer vaccine experiments. Primary lung epithelial cells from C57BL/6 mice were..

Human Smad3 and Smad4 are Sequence-Specific Transcription Activators

Mounting evidence suggests that Smad proteins are required for TGFbeta signaling, but the way(s) in which Smad proteins propagate this signal is unclear. It was found that two human Smad proteins (Sma..

Multiple Roles of Cholesterol in Hedgehog Protein Biogenesis and Signaling

The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modi..

A Set of Novel Immediate Early Genes from Brain

The present invention provides methods and materials related to immediate early genes. Specifically, the invention provides isolated immediate early gene nucleic acid, cells that contain isolated imme..

SynGAP

The PSD-95/SAP90 family of proteins have recently been implicated in the organization of synaptic structure. Here we describe the isolation of a novel ras-GTPase activating protein, GAPSYN, that speci..

Method for Generating Uniquely Immunogenic Autoantigen Fragments as Tools to Prevent and Treat Autoimmunity, and Initiate Specific Anti-Tumor Immune Responses

The present invention provides a method of producing autoantigens, compositions comprising autoantigenic fragments and methods of using autoantigenic fragments in the treatment of a condition associa..

High-throughput screening assay for mitochondrially-active drugs

Brief interruptions of coronary blood flow paradoxically protect the heart from subsequent prolonged ischemia. The basis of such endogenous cardioprotection, known as "ischemic preconditioning," remai..

14-3-3 Mediates a p53-Induced G2 Arrest

Exposure of colorectal cancer (CRC) cells to ionizing radiation results in a cell-cycle arrest in G1 and G2. The G1 arrest is due to p53-mediated induction of the cyclin-dependent kinase inhibitor p21..

Use of Multivalent Chimeric Peptide-loaded, MHC/lg Molecules to Detect, Activate or Suppress Antigen-Specific, T Cell-Dependent Immune Responses

Antigen-specific T cells play major roles in both normal physiologic immune responses as well as in many disease states. They are central in the immune response to a variety of pathogens including bac..

Blocker of Hedgehog Signalling

A Sonic hedgehog (Shh) response element was identified in the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) promoter that binds to a factor distinct from Gli, a gene known to..

Compound for Protection against Ischemia-Reperfusion Injury

An active ingredient in Chinese herbal medicine has been found to be useful for treating reperfusion injury. This plant-derived compound prevents the formation of free radicals, felt to be central to ..

Therapeutic Nanospheres

4-Phenylbutyrate exerts many beneficial biological effects. It appears to induce the transcription of certain promoters, as well as having a remedial effect on proteins which are aberrantly localized ..

Mice with Targeted Inactivation of Presenilin 1 Gene

The present invention relates to a transgenic non-human animal lacking native presenilin 1 (PS1) protein and a transgenic non-human animal expressing either the wild-type human PS1 or human PS1 contai..

Targeted Somatic Gene Transfer to Predict Drug Effects in Complex Cells and Tissues

The instant invention provides novel somatic gene transfer methods for mimicking one or more effects of a drug candidate compound. Generally stated, the methods are in vitro assays that modulate expre..

Monoclonal antibodies (and their Production) against HIV and SIV co-receptors: Chemokine receptors

These monoclonal antibodies are specific for the chemokine receptors CXCR4 and CCR5, which mediate entry of HIV and SIV into susceptible cells.

Homer Gene

The present invention is concerned with a novel family of proteins that are present in the mammalian central nervous system. These proteins are particularly characterized by (i) their enhanced express..

Semaphorins

The semaphorin gene family consists of a large family of conserved proteins several members of which have been shown to function in inhibitory and repulsive axon guidance. In addition, semaphorins may..

Nitric Oxide, and Nitric Oxide Donors, as a Therapy for the Common Cold and for Virally-Induced Asthma Attacks

The common cold is the most frequently experienced acute respiratory illness in humans. The majority of colds are due to infection with rhinoviruses. Recent evidence has also shown that upper respirat..

Tn7 Transposition Derivatives

The invention is specifically directed to efficient, random, simple insertion of a transposon or derivative transposable element into DNA in vivo or in vitro. The invention is particularly directed to..

Arachadonic Acid/Ceramide-Based Screens for Colorectal Cancer Chemopreventive Agents

Nonsteroidal antiinflammatory drugs (NSAIDS) can inhibit colorectal tumorigenesis and are one of the few agents known to be useful for the chemoprevention of neoplasia. It is shown that NSAID treatmen..

Autologous GVHD

Portions of the MHC class II invariant chain peptide, termed CLIP, exhibit immunomodulatory properties and can skew the cytokine response. In particular, the flanking regions of CLIP interact with rec..

Isolation of GRIP

The invention concerns the discovery of a novel family of proteins named as glutamate receptor interacting proteins (GRIPs). GRIPs interact with non-NMDA glutamate receptors and, in particular, intera..

Reversal of Loss of Imprinting in Tumor Cells by 5-aza-2"-deoycytidine

In order to determine whether loss of imprinting (LOI) in cancer might be reversed by altering DNA methylation, tumor cells were treated with 5-aza-2?deoxycytidine, a specific inhibitor of cytosine DN..

W162 Cells, Adenovirus Mutants H5dl1014 and H5dl1014

W162 cells are transformed Vero cells which permit highly efficient plaque formation by deletion mutant adenoviruses. These defective adenoviral deletion mutants (H5dl1011 and H5dl1014) lack coding se..

Targeted Expression of Growth Factors and Trophic Factors in the Retina and Retinal Pigmented Epithelium

The expression of vascular endothelial growth factor (VEGF) has been found to be associated with ocular neovascularization (NV) which is associated with disease processes leading to blindness, most no..

Human Blood Samples that Contain the Human Granulocytic Ehrlichia

Blood and serum samples from patients with corroborated HGE or HME. Blood samples contain antigens and nucleic acids of Anaplasma (Ehrlichia) phagocytophila (HGE) or Ehrlichia chaffeensis (HME); serum..

Plasmids Encoding the 16S rRNA Genes of Ehrlichia Equi and Human Granulocytic Ehrlichia

Cloned partial 16S rRNA genes (rrs) of several strains of Anaplasma phagocytophila (human granulocytic ehrlichiosis [HGE] agent). Description (Set) Proposed Use (Set) Used for developing molecul..

Generation of Soluble Divalent Heterodimeric Analogs of Proteins involved in Immune Responses

This invention is directed to compositions comprising soluble divalent and multivalent heterodimeric analogs of proteins that are involved in immune regulation and methods of making and using the same..

Interferon Gamma-Gene-Based Therapy in Allergic Diseases

In vivo delivery of an interferon-y gene to mucosal cells of the lung is an effective means to treat and prevent the development of allergen-induced diseases Description (Set) Proposed Use (Set) ..

Converting Cancer Genes into Killer Genes

A new gene therapy approach has been developed which exploits the genetic alternations characteristic of cancer cells. The method specifically targets cells over-expressing oncogenic proteins, resulti..

Bisulfite Modified Methylation Specific PCR

The precise mapping of DNA methylation patterns in CpG islands has become essential for understanding diverse biological processes such as the regulation of imprinted genes, X-chromosome inactivation,..

A Novel Cancer Drug Screen Based on Cell Cycle Uncoupling

Precise coordination of the S and M phases of the eukaryotic cell cycle is critical not only for normal cell division, but also for effective growth arrest under conditions of stress. When damaged, a ..

Novel Oxalate/Formate Exchange Protein

A DNA sequence encoding a transport protein responsible for the physical movement of oxalate and formate across the plasma membrane is provided. The protein, OxlT, can be isolated from the gram-negati..

Ty Transposon Plasmids

These clones (pJEF1267/pJEF1262/pD123/pX6/pJEF1114) are useful tools for generating yeast strains with multiple copies of a given gene of interest. These yeast strains contain a pre-virus coding seque..

Intervention in and Prevention of Epstein-Barr Virus Infection through Targeting of the EBNA2/CBF1 Interaction

Peptides having substantial homology with a cellular DNA-binding domain (known as CBF1/RBPJk) of the Epstein-Barr virus EBNA2 protein are the subject of this invention. EBV EBNA2 protein is one of the..

Enhancing Nerve Regeneration

Compounds have been identified which can stimulate neuronal growth by inhibiting the neuronal inhibitory activity of myelin-associated glycoprotein (MAG). Specifically, complex carbohydrates have been..

Antimalarial and Antitumor Activities of Artemisinin-Derived Trioxane Dimers with High Potency, Selectivity, and Stability

In only two steps and in 65% overall yield, natural trioxane artemisinin (I) was converted on gram scale into C-10-carba trioxane dimer (3). This new, very stable dimer was then transformed easily in ..

Antiviral Compositions and Methods of Use

This invention is related to isolation of two highly potent, non-toxic inhibitors against human immunodeficiency virus type 1 (HIV-1) integrase and viral replication. Two water soluble compounds, M522..

Structural Prediction of Allosterism

During the course of biological function, proteins interact with other proteins, ligands, substrates, inhibitors, etc. These interactions occur at precisely defined locations with the protein but thei..

An Inhibitor of Double Strand Break Repair (Non-Homologous End Joining) in Eukaryotic Cells

DNA damaging agents such as ionizing radiation and chemotherapeutics cause double-strand breaks in cellular DNA. These double-strand breaks interfere with the processes of DNA replication and chromoso..

Method for High Throughput Thermodynamic Screening of Ligands

The optimization of lead compounds as viable drug candidates involves the optimization of their binding affinity towards the selected target, most notably the achievement of high affinity and specific..

�whmd�: Essential Cell Division Gene in Mycobacteria

The slow growth rate of mycobacteria contributes significantly to the pathogenes 'is and treatment of mycobacterial infections such as tuberculosis. To combat infection, patients must undergo extended..

Compositions and Methods for Prevention of HIV Transmission Across Mucosal Surfaces

(Set) Most newly acquired cases of HIV-1 infection result from sexual, primarily heterosexual, transmission. While mechanical barriers, such as condoms, can be very effective in preventing sexual tra..

C-10 Carbon-Substituted Artemisinin-Like Trioxane Compounds Having Antimalarial, Antiproliferative and Antitumor Activities

Artemisinin is usually administered for the treatment of multi-drug resistant malaria. However, studies have determined that artemisinin not only possesses excellent anti-malarial properties but also ..

Novel Inhibitor of Programmed Cell Death

Apoptosis is the fundamental cellular process for the self-destruction of cells. Modulation of cell survival is essential to tissue development and homeostasis with aberrations of this process account..

An Epithelial Protein and DNA Thereof For Use in Early Cancer Detection

The present invention is a purified and isolated epithelial protein, peptide and variants thereof whose increased presence in an epithelial cell is at indicative of precancer. One epithelial protein w..

Water-Soluble Trioxanes as Potent and Safe Antimalarial Agents

Parasitic infections, particularly malaria, are a serious and widespread public health problem. New and better therapeutic agents are needed to fight these parasitic infections. The trioxane drug, art..

Trioxane Dimer Compounds Having Antiproliferative and Antitumor Activities

Described herein are novel trioxane dimers of structure ##STR1## which possess antiproliferative and antitumor activities. Patent (Set) 6,297,272; 5,840,925; 6,156,790; 6,160,004; 6,004,997; 730722; ..

Chemoprotective Isothiocyanates

Sulforaphane has been isolated and identified as a major and very potent phase II enzyme inducer in broccoli (Brassica oleracea italica). Sulforaphane is a monofunctional inducer, inducing phase II en..

1, 2, 4 - Trioxanes Having Antimalarial Activity

Because of the widespread incidence of malaria in certain parts of the world and because of the increasing parasite resistance to standard anti-malarial drugs, there is an urgent need for new and effe..

Early Detection of Lung Cancer Treatment

The present invention relates to a method for early detection of lung cancer. The method comprises obtaining samples from the body, especially respiratory tract material including sputum or bronchial ..

CYP2D6 and CYP3A4 double transgenic mice

Human CYP2D6 and CYP3A4 collectively metabolize over 70% of drugs on the market. In an effort To study the developmental and sexual expression and regulation of these two major human drug-metabolizing..

Murine Model for Mantle Cell Lymphoma

The rate of Non-Hodgkin’s lymphoma (NHL) is rising in the United States with over 50,000 new cases diagnosed annually. Mantle cell lymphoma (MCL), a type of NHL, is a particularly aggressive cancer ..

DEVELOPMENT OF NEW ANIMAL MODEL FOR HYPERACTIVE DISORDER AND SCHIZOPHRENIA. (Combined w/R-5825)

The study of schizophrenia and neurodegenerative diseases such as Parkinson’s Disease (PD) and the subsequent development of therapeutic agents to combat these diseases rely upon accurate non-human ..

A Rabbit Polyclonal Antibody Against Parkin

Since mutations of the parkin gene are the most frequent cause of familial Parkinson’s Disease (PD) and because heterozygous parkin mutations can also be found in sporadic PD, there is growing inter..

Rk-GFP Transgenic mouse with Rhodopsin kinase promoter driven Green Fluorescent protein with green photo receptors

This technology encompasses a transgenic mouse model, Rk-GFP, for the study of photoreceptor-specific gene expression in the retina. Unlike the currently available transgenic mice used for this purpos..

Discovery of an Integrative Nuclear FGFR1 Signaling (INFS) pathway that controls neuronal growth and survival - development of new experimental model and treatments for the Parkinson Disease (PD).

As current animal models of Parkinson's Disease (PD) fail to simulate all of the pathogenic, histological, biochemical and clinical features of the disease, their value remains limited. Therefore, it ..

Optical (and electromagnetic field) generated, dynamically controlled and configureable photonic structures (assemblies) in cholesteric liquid crystals and others chiral ordered soft materials for lif

Optical (and electromagnetic field) generated, dynamically controlled and configureable photonic structures (assemblies) in cholesteric liquid crystals and others chiral ordered soft materials for lif..

Methodology for the Synthesis of fluoride (NaYF4) nanophosphors co-doped with Gd3+ and other rare-earth ions and its applications in security printing and bimodal (optical and MRI) imaging

Methodology for the Synthesis of fluoride (NaYF4) nanophosphors co-doped with Gd3+ and other rare-earth ions and its applications in security printing and bimodal (optical and MRI) imaging Categories..

A Versatile 3-D Image Viewer for Diagnosis and Interventions

A Versatile 3-D Image Viewer for Diagnosis and InterventionsTechnology to allow surgeons to retrieve, review and interpret multimodal medical images, and to perform some critical neurosurgical procedu..

Dual PET and SPECT imaging

The ability to simultaneously monitor metabolism and biological markers in vivo has profound implications for clinical and small animal imaging. Current stand-alone imaging devices capable of these me..

A new method to determine the depth-of-interaction function for PET detectors

A method for callibrating the depth of interaction for 3D PET detector crystals. It only requires a stationary uniform radiation source. No movement of source or detectors needed and it calibrates all..

Transgenic mouse model for neurodegenerative diseases

The study of neurodegenerative diseases such as Parkinson’s Disease (PD) and the subsequent development of therapeutic agents to combat these diseases rely upon accurate non-human models that mimic ..

Method for Identifying Drug Targets in Biological Networks

This is the extension of the bridging centrality network to biological networks. In the network representation, proteins and other biological molecules are the nodes of a network and the interactions ..

Composition and Method of preparation of Lipidic particles containing VEGF for lymphadema

Pharmaceutical and immunological scientists at the University at Buffalo have developed novel formulations for cytokine and growth factor drugs, including recombinant interleukin-12 (rhIL-12), GM-CSF ..

Identification of a new Type II Heat-labile Enterotoxin

One of the factors limiting the commercial development of mucosal vaccines is the availability of appropriate, safe and effective adjuvants and antigen delivery systems that promote the desired kinds ..

Methods for Preparing Multivalent RNA-Targeting Ligands with Specific Application Towards Targeting the (CUG)n Oligomers that Cause Myotonic Dystrophy

Trinucleotide repeat disorders are genetic disorders caused by extended stretches of DNA encoded with the same trinucleotide sequence repeated many times. Some of the most notable trinucleotide repeat..

Anti-tumor compounds

Members of the inhibitor of apoptosis protein (IAP) protein family are often expressed at high levels in cancer cells. It is thought that high expression of IAP proteins leads to a disruption in the a..

Method and Composition of Less Immunogenic, Long Circulating EPO

Over one million patients in the U.S. are prescribed a therapeutic erythropoietin to treat anemia caused by kidney failure or cancer chemotherapy. It is estimated that over 80% of cancer patients and ..

Use of RNA inhibitors based on IL-14 and antibodies to IL-14 for the treatment of autoimmune diseases and lymphomas

Autoimmune disorders and B cell derived lymphomas cause life-long suffering or premature death. Often the treatment for these diseases is symptomatic at best with severe side effects. An effective new..

Using Selection to Define Rules for Small Molecule Targeting of RNA

Information needed to design nucleic acid-based compounds which target RNA can be as limited as knowing the Watson-Crick base pairing “code”. However, to date, the clinical success of such compoun..

Calcium Sulfate (sulphate)-Based Nanoparticles: Synthesis and Modification Methods and Application in Bone Regenerative Therapy

Bone regeneration within critical size defects, both in the oral cavity and throughout the rest of the body, occurs very slowly in the absence of bone stabilizing agents to act as scaffolds. Though au..

Chimeric TBP-Toxin Proteins as Mucosal Antigens for Vaccination against Neisseriae

Neisseria gonorrhoeae, the causative agent of the sexually transmitted disease gonorrhea, has been a burden to mankind from antiquity. Central to this bacteria's prolific nature, is its antigenic avar..

Method and Composition of Less Immunogenic, Long- Circulating Protein- Lipid Complexes

These novel compositions provide for enhanced delivery of protein therapeutics. Proteins (e.g. recombinant or full-length Factor VIII) associated with LIPRO-FORM (see R-6031 as well) exhibited markedl..

Method and composition of Pegylated protein (FVIII)-Phosphoserine complex

These novel compositions provide for enhanced delivery of protein therapeutics. Proteins (e.g. recombinant Factor VIII) associated with LIPRO-FORM exhibited improved pharmacokinetic profiles and highe..

Composition and method of preparation of lipid nano particulates containing antigens as cancer vaccine

Using a rational design strategy, compositions (LINAP) have been developed for the targeted delivery of cancer vaccine antigens. Designed to target Dendritic cells (DC), LINAP is able to facilitate mo..

Erogorgiaene derivatives and method for making

Marine-derived bioactive compounds hold great promise as therapeutics in the treatment of human disease. One particular family of marine-derived diterpene compounds has demonstrated anti-cancer, anti-..

Stent Vascular Intervention Device and Method Modification

A team of University at Buffalo researchers has developed novel stent vascular devices for the treatment of cerebral aneurysms. The new stents can be deployed by a conventional balloon-catheter and a ..

TLR2-mediated adjuvant activities of LT-II B subunits

The present invention deals with heat-labile enterotoxins (LT-IIs) in which the toxic A-subunits are absent, leaving only the nontoxic B pentamers. Researchers found that despite the absence of toxic ..

Gene silencing of human c-myc oncogene by poly-DNP-RNA

Overexpression of the c-myc proto-oncogene has been implicated in the onset and progression of a wide range of cancers; in restenosis following arterial injury or intervention; and in the loss and dys..

Inhibition of Mechanical Ion Channels by Peptide Enantiomers

Stretch-activated cation channels (SAC) are wide-spread in the body and trigger cellular responses to mechanical stresses. They mediate the senses of touch and hearing and help to regulate organ funct..

MUC7 12-mer-D isomer: novel and promising antimicrobial agent

This invention encompasses isomeric peptide derivatives of a naturally occurring protein found within the human body. These isomeric derivatives have been shown to possess potent antifungal activity c..

Novel Chalcogenoxanthylium Dyes for Purging Blood Pathogens

Researchers at the University at Buffalo and the American Red Cross have developed a suite of chemical compounds to be used to purge pathogens found in the blood supply. There is a dire need to in..

Adjuvant activities of a mutant LT-IIb enterotoxin lacking binding to ganglioside GD1a

UB microbiologists have developed a mutant heat-labile enterotoxin (LT-IIb) that demonstrates promising adjuvant activity and appears to overcome the limitations and concerns related to various mucosa..

Novel Human Gene with Immunoregulatory and Antiproliferative Properties

Abnormal or unregulated control of the body’s immune system can contribute to a variety of disorders, including but not limited to autoimmune disease and cancer. Standard treatments for autoimmune d..

A vaccine to prevent infection by nontypeable Haemophilus influenzae infection

Currently, there is no effective vaccine to prevent infection by non-typeable Haemophilus influenzae (NTHi), a leading cause of otitis media as well as a number of other upper respiratory tract infect..

Poly-DNP-RNA-21

The RIa/PKA gene is often overexpressed in cancers of the breast, lung, colon, prostate and ovary. UB researchers have synthesized a new compound, DNP-ssRNA-21, that triggers cleavage of the mRNA of R..

Method for preparing less-immunogenic protein-lipid complexes

A novel method has been developed for preparing less immunogenic protein formulations. One composition derived from this method has demonstrated promising results in the delivery and efficacy of prote..

21,23-Core-Modified Porphyrins as Sensitizers for Photodynamic Therapy

Photodynamic Therapy (PDT) is a unique approach to the treatment of cancer and other diseases. Able to differentiate cancerous and normal tissue while minimizing or eliminating many of the side effect..

Organic Mixtures for the Encapsulation of Proteins in Dispersed Systems

Liposome technologies were developed to circumvent the problems associated with delivering therapeutic proteins into the human body. By encapsulating the protein of interest, the liposome allows the p..

Chimeric LT-II toxins as adjuvant-carrier molecules

One of the factors limiting the commercial development of mucosal vaccines is the availability of appropriate, safe and effective adjuvants, or delivery systems that promote the desired kinds of immun..

HIV antisense ORF(s) and putative protein(s)

The current invention is a gene comprising an open reading frame on the plus strand of the pro-viral DNA, and located in the region of HIV-1 long terminal repeat. The gene encodes a protein that is re..

OUTER MEMBRANE PROTEIN B1 OF MORAXELLA CATARRHALIS

The present invention includes a method for the isolation and purification of outer membrane protein B1 as well as B1 peptides from Moraxella catarrhalis, and the resulting compositions. The method in..

Biological Vaccine Delivery System

This invention relates to methods and compositions for producing a fusion protein comprised of Haemophilus influenae P2 amino acid sequences, wherein in place of loop 5, or a portion thereof, is displ..

Improved use of Recombinant Viruses for Liver Regeneration

Introduction Diseases of the liver, both genetic and acquired, are especially detrimental due to the fact that the liver is a key organ for most metabolic pathways. Currently, the only method of curin..

VACCINIA ANTIGENS FOR DEVELOPMENT OF A SMALLPOX VACCINE

Introduction Smallpox is a disease of increasing biodefense importance. The current smallpox vaccine is too virulent, and therefore unsafe, for up to 5% to 10% of the American public. Vaccinia are vir..

Specific glycan-modified HIV envelope proteins as vaccine immunogens against

Introduction A major obstacle in current AIDS/HIV vaccine development is the failure to induce broadly neutralizing antibodies against primary isolates of human immunodeficiency virus. Standard vaccin..

Respiratory Detection System (RDS)

Introduction Respiration rates are an important indicator of cellular and metabolic states in cells ranging from mammalian to bacterial, from individuals to large populations. Unfortunately, conventio..

BCRP expressing cell lines

Introduction The breast cancer resistance protein (BCRP) is an ATP-binding cassette efflux transporter originally identified by its ability to confer multidrug resistance in cancer cells. BCRP mediate..

Genetically Encoded Cell Death Reporter

Introduction Determining cell viability is critical to a wide variety of scientific disciplines. Currently, cell viability is assessed by incubating the cells of interest with a chemical dye or stain ..

Dynamic Characterization of Particles Using Flow Cytometry

Introduction Flow cytometry is an increasingly useful analytical technique that utilizes the scattering of laser light to interrogate a variety of microparticles, including microorganisms, cells, and ..

Ultrasonic Probe for Determination of Kidney Stone Size

Introduction Kidney stones are a common problem for men and women worldwide that can cause great pain and lead to complications, such as infection. Conventional treatments such as extracorporeal shock..

Nanocellular Foaming of Ultra High Molecular Weight Polyethylene using Ultrasound

Introduction Ultra high molecular weight polyethylene (UHMWPE) is a thermoplastic consisting of molecules of incredibly long chains with molecular weights of several million. It has the highest impact..

Technique for Detecting Loose Arthroplasty Components

Introduction Due to traumatic injury, severe arthritis, and similar conditions, total joint replacement surgery (or arthroplasty) is becoming increasingly common. Despite the field’s maturity, howev..

Optimal Fitting of Prosthetic Limbs: Evaluation of Prosthetic Socket Quality and Soft-Tissue Response

Introduction The process of fitting prosthetic limbs to amputees can be a long process of trial and error. Two common obstacles to the optimal fitting of prosthetic limbs are improperly tooled prosthe..

Attenuating Mutations for Tularemia Live Vaccine

Introduction Francisella tularensis is a bacterial pathogen that causes the zoonotic disease tularemia and that is often transmitted to humans through the bite of ticks or mosquitoes, inhalation of ha..

Technique for Detecting Loose Arthroplasty Components

Inhibition of the Foreign Body Reaction

Introduction It is crucial to control the chronic inflammation typical of many implantable medical devices such as cardiovascular stents, vascular grafts, and intraocular lenses to promote their longe..

Methods and Compositions for the Treatment of Neurological Diseases

Introduction Amyloid β (Aβ) peptides are thought to be the key pathogenic element in the initiation and progression of Alzheimer’s disease (AD) and alpha-synuclein (αS) is thought to play a simil..

Recombinant adenoviral vectors expressing chimeric fiber proteins for cell specific infection and genome integration

Introduction Gene transfer vectors require the efficient transduction of target cells, stable association with the host genome, and adequate transgene expression in the appropriate target cell, withou..

Methods and Compositions for enhanced stability of non-adenoviral DNA

Introduction A central challenge in gene therapy is delivering the therapeutic gene to the tissue site where it can be of benefit. Many pathological conditions have been identified that should be amen..

Botanicals as Antiviral and Hepatoprotective Compounds for Hepatitis C Virus Infection

Introduction Hepatitis C virus (HCV) is one of the several viruses that cause hepatitis, i.e., inflammation of the liver. The infection is usually chronic, and results in fibrosis, cirrhosis (scarrin..

Innovative and Targeted Treatment of Kidney Disease

Introduction Twenty million Americans are currently afflicted with kidney disease, and this number is expected to more than double in the next decade. UW scientists have identified that treatment with..

Gold Vision

Introduction A neuron or group of neurons that senses or receives light within the eye is known as a photoreceptor. Damaged or diseased photoreceptors lead to impaired vision or blindness. Local stimu..

Safe, effective and selective oral androgen therapy with the combination of high-dose oral testosterone or testosterone esters and a dual 5-alpha reductase inhibitor

Introduction Men with a testosterone deficiency may have symptoms of depression, reduced libido, and low energy. They may suffer from anemia, osteoporosis and debilitating muscle weakness. Testosteron..

Chlamydia Oligosaccharides

Introduction Chlamydia trachomatis is an obligate intracellular bacterium which parasites eukaryotic cells and is one of the most common causes of blindness and sexually transmitted diseases in humans..

Improved use of Recombinant Viruses for Liver Regeneration

Hexon-Modified Adenovirus Vectors that are Unable to Bind Human Blood Factors and Their Use

Introduction Human species C adenovirus serotype 5 (Ad5) is the most common viral vector used in clinical studies worldwide. Ad5 vectors infect liver cells in vivo with high efficiency via a poorly de..

Nav1.2/β1/contactin cell line

Introduction Mammalian Na+ channels are heteromultimeric structures that include the poreforming α subunit in association with auxiliary β subunits. Contactin is a neuronal cell adhesion molecule o..

Respiratory Detection System (RDS)

Cryopreservation of Human Embryonic Stem Cells

Introduction Embryonic stem cells (ESC) have unique capacities both for self-renewal and pluripotency. Human ESCs (hESCs) are therefore a potential source for regenerative medicine and tissue replacem..

BCRP expressing cell lines

cDNA for B1 subunits of human sodium channels

Introduction Voltage-gated sodium channels in the brain are composed of a central, pore-forming α subunit and one or two β subunits. Sodium channel β1 subunits modulate α subunit gating and cell s..

Identification of Genes Involved in Aging

Introduction Genes involved in aging are targets for diagnostic, prognostic, and therapeutic products related to aging. This technology encompasses methods, reagents, and compounds that can be used ei..

Selective Detection of Phosphoproteins

Introduction Mass spectrometry enrichment and detection of phosphoproteins is critical to cancer research and drug development, among many applications. In MALDI-TOF mass spectrometry, metal plates de..

Inductive Salinometer with Data Logging Capabilities and Toroidal Sensor

Introduction Salinity levels in seawater are not constant and can vary dramatically both temporally and spatially due to phenomena such as temperature, precipitation, deep-water upwelling, and tidal a..

Method of Detecting, Characterizing, and Quantifying Bulk, Light-Element Materials Using High-Energy, Penetrating X-Rays

Introduction X-rays have long been used in the characterization of a wide variety of materials. However, conventional techniques for dealing with light-element (or low-Z) materials, such as those cont..

Respiratory Detection System (RDS)

Production of Palladium Nanostructures with Shape Selection by Adding Bromide

Introduction Single-crystal, one-dimensional nanostructures of palladium are attractive as interconnects for fabricating nanoscale electronic devices. Polycrystalline, mesoscopic wires made of palladi..

Novel Gadolinium nanoparticles for Magnetic Resonance Lymphatic Imaging

Introduction Gadolinium (Gd3+) is chelated with diethylenentriaminepentaacetyl (DTPA) to provide contrast in magnetic resonance (MR) imaging to identify pathogenic tissues. Unfortunately, the Gd3+-DTP..

Inductive Salinometer with Data Logging Capabilities and Toroidal Sensor

Novel Adsorbent Systems for Water Purification Using Metal Oxide Bound to Substrate and Heated Metal Oxide Particles

Introduction There is an ever increasing need for potable water. Improvements in conventional purification technologies allow for savings in both time and money and ensure that clean water is availabl..

Novel Gadolinium nanoparticles for Magnetic Resonance Lymphatic Imaging

Method of Detecting, Characterizing, and Quantifying Bulk, Light-Element Materials Using High-Energy, Penetrating X-Rays

Cardiac PET/CT and SPECT/CT automated attenuation correction quality control alignment

Introduction In dual-modality PET/CT and SPECT/CT systems, the CT scan provides the attenuation map for PET attenuation correction (AC). These attenuation maps are often misaligned due to patient move..

A Bifunctional Poly(ethylene glycol) Silane Immobilized on Metallic Oxide-Based Nanoparticles for Conjugation with Cell Targeting Agents

Introduction Magnetic resonance imaging (MRI) is a non-invasive diagnostic and therapeutic methodology. The limitations of this imaging system are in its resolution. Lesions within the body must be ap..

Biomarkers for Cardiovascular Disease

Introduction Cardiovascular disease (CVD) is the leading cause of death among both men and women in the United States and, as such, is associated with high costs in terms of health care, morbidity, an..

Keratinocytes Derived from Human Embryonic Stem Cells

Summary The investigator has discovered a method for isolating and propogating keratinocytes from human embryonic stem (ES) cells. Production of an isolated keratinocyte culture proceeded step-wise fr..

Purification of a Smooth Muscle Cell Mitogen from Beta Tumor Cell Conditioned Me

Summary This invention describes a novel human growth factor, sometimes referred to as "BTC-GF". BTC-GF is a mitogen for smooth muscle cells, 3T3 fibroblasts, and retinal pigment epithelial cells, but..

Novel Peptide Therapeutic for Multiple Sclerosis

Summary Background: In Multiple Sclerosis, the hostâ€™s immune system (lead by T cells) attacks and destroys myelin basic protein, the principle component necessary for nerve transmission. Part a..

In Vivo Evolution of an RNA-Based Transcriptional Activator

Summary This invention claims a method of evolving potent RNA transcriptional regulators using a combination of directed evolution and site directed mutagenesis. Also described are specifically evolve..

Manipulating Stem Cells for Repair and Drug Delivery at Various Anatomic Sites

Summary Cellular and gene therapy for chronic drug delivery and tissue repair have been explored in a range of anatomic sites including the heart, brain, bone marrow, and skeletal muscle. Mashimo and ..

Tome-1, a novel cell-cycle gene required for mitotic entry

Summary This invention, out of Marc Kirschner's research group, concerns the discovery of a novel protein required for mititic entry. Harvard researchers have isolated and identified the protein and t..

BACE1 siRNA reduces A-Beta peptides in vivo

Summary BACE1 is a beta-secretase shown to cleave precursor molecules leading to the formation of amyloid proteins and plaques in Alzheimers patients. Dr. Li-huei Tsai and her collaborator Ken Kosik, ..

Novel Peptide Therapeutic for Multiple Sclerosis

Summary Background: In Multiple Sclerosis, the host immune system (lead by T cells) attacks and destroys myelin basic protein, the principle component necessary for nerve transmission. Part and parcel..

IL-8R and STAT-3 Modulation: Targeting Glioblastoma Multiforme and Other Brain Tumors

Summary There is an unmet need for better therapies against high grade anaplastic astrocytoma and glioblastoma multiforme. Recent results suggest that that inhibiting IL-8 receptor activity and enhanc..

Novel Cancer Target Following HDAC Track: First Histone Demethylase offers opportunity in treating resistant cancers

Summary The invention encompasses a novel target representing a potential new avenue in the treatment of cancer and other diseases, based on interference with gene regulation. The target, LSD1 (lysine..

A Novel Class of HIV Therapeutics: Monoclonal Antibodies that Neutralize Previously Resistant HIV Primary Isolates

Summary Background: Molecular studies of the genomic organization of HIV-1 show that it encodes a number of genes common to all retroviruses, such as the gag, pol, and env genes. The env gene of HIV-1..

Tubacin for Myeloma Therapy

Summary Background: Nearly 10 million people throughout the world are diagnosed with cancer each year. The direct and indirect medical costs to treat cancer total more than $180 billion each year, and..

Novel Avrainvillamide-like Compounds with Anti-proliferative Properties

Summary Avrainvillamide and stephacidin B, (a dimer of avrainvillamide) have been identified in culture media from various strains of the fungus Aspergillus. Both compounds demonstrate anti-proliferat..

Novel Clinical Stage Treatments for Epilepsy and Pain

Summary The principal investigator has discovered that Huperzine A (HupA) is characterized by extremely potent therapeutic activity against epilepsy and chronic pain. HupA was tested in a formalin mod..

Endowment angiogenesis-related patents

Summary Angiogenin is an extensively validated target involved in tumor angiogenesis. Angiogenin is prominently increased in multiple cancer cell types, including, prostate, colon, bladder, gastric, b..

Small Molecule Microarrays: A New Forefront in Drug Discovery

Summary Scientists from the laboratory of Professor Stuart Schreiber at Harvard University have developed a novel method of printing small molecule libraries on glass microscope slides. This method re..

Treating Diseases Associated with Oxidative Stress through the Metalothioneine System

Summary Since its initial discovery and characterization over 40 years ago by Vallee and colleagues, metallothionein has attracted a remarkable level of scientific attention due to its unique structur..

Dimeric HDAC Inhibitors

Application of streptococcus intermedius intermedilysin (ILY) for obesity treatment and contraception

Summary A bacterial toxin has been shown to enhance immune reactions to adipocytes when injected locally, facilitating antibody-mediated and complement-dependant cytolysis. Applications A peptide t..

SMERs: Small Molecule Enhancers for Treatment of Cancer and Neurodegenerative Diseases

Summary Background: Autophagy is the process by which cells cannibalize cellular elements such as proteins and organelles to generate intracellular metabolites for cell survival and cell death. For ex..

HIV Small Molecule Fusion Inhibitors

Summary Viral fusion inhibitors represent the newest class of HIV drugs. Fuzeon (enfuvirtide), a synthetic peptide, is the first viral fusion inhibitor to be approved by the FDA, and works by interfer..

Structure activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5

Summary A new paradigm in cell death has been discovered, Necroptosis. Necroptosis reflects a distinct mechanistic pattern of programmed cell death that combines elements of passive unregulated necros..

Identification of Contactins and L1-CAMs as ligands for the Amyloid Precursor Protein

Summary Approximately 24 million people worldwide have dementia of which the majority (~60%) is due to Alzheimerâ€™s; by 2040, it is projected that this figure will have increased to 81 million. ..

Synthetic trivalent haptens that form stable bicyclic trimeric complexes with anti-hapten antibodies -- a platform technology for developing new diagnostics and therapeutics

Summary Markets/Needs Addressed: The detection or modulation of the activity of antibodies in vivo and in vitro is important for a wide range of diagnostic and therapeutic applications. However, the ..

Novel Urazole Epoxyquinol Inhibitors of Hepatitis C Virus Replication

Summary Background: Hepatitis C virus (HCV) infects about 200 million people worldwide and frequently leads to cirrhosis, liver failure, and hepatocellular carcinoma. Currently, the best therapy for t..

Novel and Efficient Algorithm for Analyzing Large Genotypic and Phenotypic Data Sets in Clinical Trials

Summary Background: Recent technologies such as genotype sequencing and gene expression arrays result in datasets that typically have many more variables than data points. As a consequence, these vari..

Non-ATP competitive Inhibitors of Aurora Kinases: Selective and Potent Cancer Treatment

Summary Markets / Needs Addressed: Aurora kinases are overexpressed in many tumors including breast, cervical, colon, and pancreatic cancers. Aurora kinases are expressed only in actively dividing ce..

A potent antifungal agent from a Streptomycete

Summary Study of a unique Streptomycete has yielded a novel anti-fungal agent. The spectrum of activity of the isolated anti-fungal agent is similar to that of amphotericin but approximately three-tim..

Small-molecule inhibitors of Chlamydia cell growth

Summary Small molecule inhibitors of CopN for the treatment of Chlamydia pneumoniae associated pneumonia and vascular disease. See Huang et al. Nature 01 Oct 2008. CopN is a member of a family of p..

Inhibitors of Cellular Necrosis III (thiadiazoles)

Inhibitors of Cellular Necrosis III (non-thiadiazoles)

Small molecule regulators of autophagy identified by an image-based high throughput screen

Summary Compounds for the induction of autophagy and screening methods for further identification of autophagy inducing compounds. Autophagy is a lysosome-dependent process whereby proteins or dama..

Inhibition of Sirt$ for treatment of obesity and ehancing fat metabolism

Summary A method of screening for compounds that modulate SIRT4 fatty acid oxidation activity. SIRT4 is a mitochondrial protein that plays a central role in regulating amino acid stimulated insulin..

Treating Diseases Associated with Oxidative Stress through the Metalothioneine System

Methods for Improved Viability of Cells at Low Temperature

Summary Discovery of the linkage between the expression of Trigger Factor, a protein of previously-unknown function, and resistance of living cells to cold-shock has led to development of methods that..

Vaccine Compositions AMPERSAND Methods for Human Papilloma Virus

Summary This invention comprises methods of expressing the Human Papilloma Virus L1 and L2 proteins, and variations thereof, in bacterial host cells; the purification of the expressed proteins; and th..

Dominant negative inhibitor of anthrax toxin

Summary The invention enables prevention and emergency treatment of anthrax. It provides a dominant negative inhibitor (DNI) of an essential infectivity factor of B. anthracis, a potentially lethal pa..

Manipulating Stem Cells for Repair and Drug Delivery at Various Anatomic Sites

Dual-activity anthrax vaccine

Summary There is a need for improved anthrax vaccines. First, because of the low immunogenicity of the bacterial coat components of Bacillus anthracis, existing vaccines typically are directed at a se..

Next Generation Pulmonary Malarial Vaccine

Summary Scientists encounter difficult obstacles in attempting to develop vaccines against malaria. For example, malaria parasites of the same species but isolated from different geographic locations ..

Prevention of Tularemia Using an Enhanced Live Attenuated Vaccine Strain

Summary Francisella tularensis (F. tularensis) is an intracellular and facultative bacterium that is the etiological agent of tularemia. Government concern over F. tularensis as a biowarfare agent has..

AIDS vaccine using gamma-2 herpesvirus as a vector to express lentiviral (AIDS virus) genes

Summary A novel vaccine strategy, using recombinant rhesus monkey rhadinovirus, a close relative to human herpesvirus 8, has been developed at the lab of Dr. Desrosiers. Testing in primates demonstrat..

Multivalent Vaccine against Marek's Disease and Highly Pathogenic Avian Influenza Virus

Summary Protective immunity against avian influenza, H5N1 subtype, may be provided economically using a multivalent vaccine against both avian influenza and Marekâ€™s disease, a common vaccinatio..

Methods for Improved Viability of Cells at Low Temperature

Surface-Bound, Bimolecular, Double-Stranded DNA Arrays

Summary The invention, developed at Harvard Medical School, achieves high array feature density and accurate feature production through enzymatic second-strand synthesis of immobilized single-stranded..

Production and uses of polymerase colony ("polony") arrays

Summary The invention provides methods for rapid fabrication and use of replicable, high-density nucleic acid arrays. Array features are produced through amplification on a support matrix of nucleic a..

Surface-Bound Double-Stranded DNA Protein Arrays

Summary Developed at Harvard Medical School, this invention provides nucleic acid arrays specifically designed for the assay of DNA-dependent protein:protein binding and/or physical interactions betwe..

Hyperactive mutant of the Himar1 mariner transposase

Summary Mariner-family transposable elements are active in a wide variety of organisms and so are important genetic engineering tools. The Himar1 element, isolated from the horn fly, Haematobia irrita..

Bead-based polymerase colony microarrays and nucleic acid sequencing ("Polony-FISSEQ Beads")

Summary Foundational work of Dr. George Church has enabled the production and use of replicable arrays of polymerase-amplified nucleic acid colonies (so-called "polonies") on semisolid support matrice..

Modular Conditional Knockout: Precise Temporal Control of Protein Degradation in Living Cells

Summary Polyubiquitinated proteins in eukaryotes are directed to the proteasome for degradation. It is generally accepted that proteasome-mediated proteolysis depends strictly upon ubiquitination, as ..

Genetic Test for Periodontal Disease

Summary Peridontitis is a serious oral disease characterized by highly painful loss of tissue between the tooth and the gingival tissue. In the US, it is estimated that dentists perform upwards of 28...

C16:1n7-palmitoleate: A novel lipid hormone as a diagnostic and therapeutic tool

Summary Markets / Needs Addressed: Insulin resistance is the key factor of a collection of metabolic disorders including Type II diabetes, atherosclerosis, fatty liver disease, hypertension and dyslip..

A microfluidic differential manometer for cellular-scale hydrodynamics

Summary Background: The development and application of microfluidic systems have increased dramatically in recent years. The systems that typically involve controlled fluid flow through a number of..

Enhanced Nanoparticle-Based Molecular Imaging via MRI

Summary Enhanced Nanoparticle-Based Molecular Imaging via MRI Elevator pitch: For biotech and pharmaceutical companies who need to track drug effectiveness in the drug discovery and for MRI facili..

Engineering 3D and Free Standing Tissue Structures

Summary Background: Efforts to build biosynthetic materials or engineered tissues that recapitulate the structure-function relationships of natural processes often fail because of an inability to repl..

Microfluidic Platform for Constructing Tunable 3D Cellular Microenvironments for Performing Biologically Relevant Cell-Based Assays

Summary Markets/Needs Addressed: In vitro studies of living cells are commonly carried out in 2-dimensional (2D) systems involving cells grown in monolayers in glass or polystyrene Petri dishes. The ..

Hydroxapatite -Antigen Conjugates AMPERSAND Methods for Generating A Poly-IG Immune Resp

Summary Issued patents 5,443,832: SUMMARY OF THE INVENTION We have discovered that hydroxylated calcium phosphate (HCP) particulate is a particularly useful carrier for antigens to be applied to..

A microfluidic differential manometer for cellular-scale hydrodynamics

Summary Background: The development and application of microfluidic systems have increased dramatically in recent years. The systems that typically involve controlled fluid flow through a number of..

Treating Diseases Associated with Oxidative Stress through the Metalothioneine System

Purification of a Smooth Muscle Cell Mitogen from Beta Tumor Cell Conditioned Me

Monoamine Transporters: New Targets for Cocaine Abuse and CNS Diseases/Disorders Treatment

Summary This summary describes classes of compounds jointly designed, synthesized and evaluated through a collaboration between the laboratories of Professor Bertha K. Madras of Harvard Medical School..

Method and Kit for Evaluating Transformed Cells

Summary Human papillomaviruses (HPV's) are small DNA viruses of the papovavirus family that infect human epithelial cells. â€œLow riskâ€ HPVâ€™s can cause benign hyperplasiaâ€™s suc..

Liposome- Based, Intracellular Delivery of Drugs into Phagocytes, B- and T- cells and their tumor cells

Summary Liposomes are man-made spheres, or vesicles, with an aqueous interior enclosed by one or more phospholipid bilayers. Liposomes can enhance the pharmacokinetics and efficacy of therapeutics by ..

A Strain of the Ehrlichial Agent

Summary The NCH-1 strain of the agent of human granulocytic ehrlichiosis (HGE), isolated from a Nantucket patient in 1994, is available as a continuous culture in HL60 promyelocytic leukemia cells. Th..

Methods of Detecting and Treating Vaso-Occlusive Crisis in Sickle Cell Disease

Summary Sickle cell anemia is a genetic disorder caused by abnormal hemoglobin (Hgb S). Polymerization of Hgb S in the red blood cells distorts the cell shape causing abnormal cell function and premat..

Gene Therapy For Papillomavirus Induced Cervical Carcinoma

Summary Human papillomaviruses (HPV) have been linked to widespread, serious human diseases, especially carcinomas of the genital and oral mucosa.. These infections frequently lead to cancer of the ce..

Methods for Improved Viability of Cells at Low Temperature

Antisense Inhibition of Angiogenin Expression in Cancer

Summary Antisense oligonucleotides targeted to anigogenin and designed based on the known sequence of the ANG gene have been synthesized. Angiogenin is a potent positive mediator of neovascularization..

Cell Based Assay for Discovery of Glycogen Synthase Kinase Inhibitors

Summary Background: Lithium exhibits numerous physiological effects in animals. For example, lithium mimics insulin action by stimulating glycogen synthesis and is remarkably effective for the treatme..

Novel Chemistry and Method to make Compounds Active Against Picornaviruses

Summary Picornaviruses are a large family of viruses responsible for many serious human and animal diseases, including hepatitis A, meningitis, diarrhea, summer flu, the common cold and polio. Several..

Cellular Basis of Vascular-Graft Stenosis

Summary The invention features a mouse model of vascular graft stenosis in which the stenosis develops rapidly and closely mimics the development of vascular graft stenosis in humans. Methods of surgi..

Systematic, condition-independent identification of essential genes of microorganisms

Summary Traditional antibiotics have been aimed at a small subset of cellular processes (such as cell wall synthesis, protein synthesis and mRNA synthesis) and targets (including DNA gyrase and the ce..

Polo-Like Kinase Polo Box: Lead Target for Cancer Therapeutics

Summary Elevated expression of mammalian polo-like kinase (Plk) 1 occurs in many different types of cancers, such as head and neck, squamous cell carcinomas, oropharyngeal carcinomas, non-small cell l..

Drug screening tool for herpes antivirals

Summary Harvard Medical School researchers have developed a genetically modified herpes simplex virus that has utility as a drug screening tool. To develop this tool, Harvard researchers engineered a ..

Small Molecule Therapeutic and Screening Assays for Drugs Active Against Chronic Neural Degenerative Diseases.

Summary Huntington's disease, as well as other ataxias, are caused by the abnormal expansion of nucleic acid CAG repeats that code a glutamine stretch. These repeats are found within several otherwise..

Vaccine Compositions AMPERSAND Methods for Human Papilloma Virus

Valpha24JalphaQ Receptor: Lead Diagnostic and Therapeutic for Type I Diabetes

Summary Background: Autoimmune diseases are the result of a patient's immune system attacking their own cells and tissues. This can result in a wide variety of diseases, including multiple sclerosis, ..

Direct and Practical Synthetic Route to Pseudopterosins: Important Anti-Inflammatory, Anti-Pain, and Anti-Irritant Compounds

Summary Background: The pseudopterosins are a group of diterpene glycosides isolated from the Caribbean sea whip, Pseudopterogorgia elisabethae. The pseudopterosins represent an important structural c..

Identification of a Sequence Element from p53 that Signals for Mdm2-targeted Deg

Research at Harvard University has led to a novel means of protecting the cell against oncogenic tumor formation. This invention provides compositions and methods for inhibiting degradation of tumor..

Identification and Characterization of Class II HDACs: Lead Targets for Treatment of Cancer and Neurodegenerative Diseases

Summary Background: One promising target of recent cancer therapy research involves a family of proteins primarily involved in gene regulation known as histone deacetylases or HDACs. Currently there a..

Identification and Characterization of Class II HDACs: Lead Targets for Treatment of Cancer and Neurodegenerative Diseases

Use of glycated CD59 levels to assess glycemic control in diabetic patients

Summary The invention enables rapid detection of impaired glucose tolerance (IGT, or â€œpre-diabetesâ€) without oral glucose tolerance testing and permits identification of a population at ri..

Fetal Alcohol/Alcoholism therapy

Summary Fetal Alcohol Syndrome and alcoholism are major social and medical problems worldwide. Recent evidence suggests that alcohols alter nervous system function by interacting directly with selecti..

Hyperactive mutant of the Himar1 mariner transposase

Next Generation Diagnostics for Breast Cancer, Prostate Cancer, and Melanoma

Summary From the labs of Professor Alun Jones (inventor of CardioliteTM) and Professor Ashfaq Mahmood, comes a series of small molecule imaging probes, capable of conjugation to both SPECT-based and P..

Methods to Regulate the Duration of Th2 Activation

Summary TID1 encodes two human mitochondrial matrix localized splice variants. Expression of each of two splice variants has opposing effects on the cell's ability to respond to exogenous apoptotic st..

Inhibitors of Cellular Necrosis

Toxin-Phage Bacteriocide Antibiotic and Uses Thereof

Summary The rise of antibiotic resistant bacterial strains will necessitate the development of new strategies for treating bacterial infections. One potential alternative to conventional antibiotics i..

Treatment of alcoholism and substance abuse using selective inhibition of alpha 2 adrenergic receptors and dopamine D2 receptors

Summary To date, most alcohol and substance-abuse drugs have been plagued by moderate efficacy and a lack of specific target mechanisms. A new approach is proposed involving weighted inhibition of the..

Mu Opioid Peptidomimetics: Lead Compounds for the Treatment of Pain

Summary Background: Although peptides have shown some promise in clinical trials as therapeutic agents, their success has largely been limited by several factors, including rapid degradation by peptid..

Col 2A promoter Cre transgenic mice

Summary Description: Modulating gene activity on chondrocytes Transgenic mice were generated in which the regulatory sequences for the Col2a1 gene were used to drive expression of Cre recombinase i..

Animal Model of Diabetes and Obesity: Cross-bred JNK1 KO/JNK 2 KO Mice

Summary Mice with the JNK 1 and JNK2 genes knocked out were crossed with the obese mouse line (ob/ob) to create a mouse model of diabetes and obesity. These mice exhibit many of the hallmark metabolic..

BACE1 siRNA reduces A-Beta peptides in vivo

Saframycin Assay

Summary Background: Chemotherapeutic DNA-binding compounds exert their effects, in part, by preventing DNA synthesis and initiating events that leads to apoptotic death. Despite the excellent antiprol..

Susceptibility to Tuberculosis 1 (sst1): Novel Target for Diagnosis and Treatment of Mycobacterium tuberculosis

Summary Background: Tuberculosis is the seventh most important cause of global premature mortality and disability. Currently there are 8 million new cases and 3 million deaths annually from tuberculos..

Transgenic GFP-Rhodopsin Zebrafish Model System for Study of Retinal Disease

Summary Background: Rhodopsin is a G-protein coupled receptor that initiates the light response upon absorption of a photon in the outer segment of the retina (ROS). Rhodopsin constitutes at least 90%..

A Novel Class of Proteosome Inhibitors

Summary Harvard Medical School investigators has discovered a number of anticancer small molecules, termed ubistatins, that inhibit cell cycle machinery through interference with the ubiquitin-proteas..

Small Molecule Approaches to the Management of Macular Degeneration by Short-Circuiting the Visual Cycle

Summary Age related macular degeneration (AMD) affects millions of persons worldwide and is a leading cause of vision loss and blindness in ageing populations. In this disease, daytime vision (cone do..

Keratinocytes Derived from Human Embryonic Stem Cells

Novel Candidates for Tuberculosis Therapy

Summary There is a need for new antibiotics that are useful against tuberculosis. Proteasomes of Mycobacterium tuberculosium are essential in enabling these bacteria to evade killing by macrophages of..

Specific Targeting of Cell Division (and Cancer): Small molecule inhibitors of Eg5 Hold Potential for Enhanced Safety

Summary Prof. Mitchisonâ€™s group at Harvard was the first to show, very elegantly, that it is possible to specifically target cell division proteins other than tubulin by using a small molecule,..

Next Generation Pulmonary Malarial Vaccine

Novel Anti-CMV Small Molecules

Summary Five structurally diverse small molecules have been discovered that inhibit human cytomegalovirus (CMV) replication with sub- to low micro-molar potency and at concentrations of up to 500-fold..

Genetic Test for Periodontal Disease

Novel Peptide Therapeutic for Multiple Sclerosis

IL-8R and STAT-3 Modulation: Targeting Glioblastoma Multiforme and Other Brain Tumors

Simultaneous Study of Multiple Genetic Interactions Using Multi-mutant Yeast

Summary While the Saccharomyces Genome Deletion Project succeeded in deleting many open reading frames in the S. cerevisiae genome, the possibility of multiple deletions in the same strain still repre..

A Novel Class of HIV Therapeutics: Monoclonal Antibodies that Neutralize Previously Resistant HIV Primary Isolates

Tubacin for Myeloma Therapy

Novel Avrainvillamide-like Compounds with Anti-proliferative Properties

Novel Clinical Stage Treatments for Epilepsy and Pain

Targeting the Par-4 Protein as a Novel Approach in Depression Treatment

Summary Harvard researchers have discovered methods for identifying agents that modulate the interaction between Par-4 and the dopamine D2 receptor (D2DR). The ability to screen for this interaction m..

Proteasome-Mediated Degradation of RISC: Lead Target for Treatment of Long-Term Memory Disorders

Summary Background: Breakthrough research by Professor Sam Kunes and colleagues at Harvard University demonstrates that degradative control of the miRNA RISC pathway underlies the synaptic pattern of ..

Prevention of Tularemia Using an Enhanced Live Attenuated Vaccine Strain

necrostatin

Wnt1-Cre transgenic mouse model

Summary Background: The ability to generate specific genetic modifications in mice provides a powerful approach to assess gene function. As such systems allowing conditional genetic modification have ..

Targeting FtsZ Activity Using Novel Antibacterials: Screening Assays, Small Molecule Hits, and Synthetic Pathways to Potent Natural Products

Summary The emergence of bacterial strains resistant to current drugs has prompted a renewed effort to discover new methods for fighting infectious disease. A promising new target is FtsZ, a key media..

Attenuated RNA Viruses for Vacine and Drug Delivery

Summary Research in the lab of Prof. Sean Whelan has revealed new compositions to attenuate non-segmented negative-sense RNA (nsNS) viruses. Successful attenuation was demonstrated on vesicular stomat..

Endowment angiogenesis-related patents

Novel Biomarkers for Chronic Myelogenous Leukemia (CML)

Summary A high-dimensional metabolomics screen to diagnose and monitor chronic myeloid leukemia (CML) has been developed. Over 3000 metabolites are detected to yield a â€˜cytogenetic signatureâ�..

siRNA treatment for HSV-2 infection

Summary A novel strategy for the prevention and treatment of sexually transmitted viruses has been developed by Dr. David Knipe that topically administers siRNA to the vagina for use as a microbicide...

Brainbow Mice: A Technicolor Approach to map the Neuronal Circuits

Summary Understanding how the precise interconnections of neurons account for brain functions has been a preoccupation of neuroscientists for over a century. The primary obstacle that researchers have..

Transgenic Mice with Fluorescently Tagged Neuronal Mitochondria as a New Tool to Study Axonal Transport

Summary Background: Axonal transport supplies organelles to axons and synapses but little is known about how organelles are distributed among the branches of an axon to insure adequate supply of resou..

A Novel Screening Method for Assessment of Psychopathologic Disorders

Summary Background: The advancement in psychiatric genetics and clinical neuroscience is hindered by the heterogeneity of psychiatric disorders and by difficulties in defining and characterizing the p..

Compositions and Methods for the Prevention; or Treatment of Infection by Psuedomonas aeruginosa

Summary An antibody has been shown to reduce the pathogenicty of gram-negative pathogens such as P. aeruginosa and V. cholerae. This new technology provides an antibody based therapeutic for potential..

Treating Diseases Associated with Oxidative Stress through the Metalothioneine System

Dimeric HDAC Inhibitors

HEK293T cells stably expressing Divalent Metal Transporter-1 (DMT1-1): Model System to Screen for Inhibitors of Iron Uptake

Summary A HEK293T cell line that stably expresses Divalent Metal Transporter-1 (DMT-1). DMT1 functions in transport of ferrous iron across the plasma membrane and/or out of the endosomal compartment. ..

A Low Cost and Versatile Microbial Fuel Cell

Summary A novel, low-cost microbial fuel cell (MFC) capable of delivering high power, high-efficiency energy. The MFC takes advantage of an easily accessible and ubiquitous carbon source. The organic ..

Compounds and Methods for Tumor-Specific Targeting

Summary A novel strategy for developing cancer-homing drugs has been developed by Dr. Amin Kassis that combines Enzyme-Mediated Cancer Imaging and Therapy (EMCIT) with radionuclides (see figure below)..

AIDS vaccine using gamma-2 herpesvirus as a vector to express lentiviral (AIDS virus) genes

Novel Urazole Epoxyquinol Inhibitors of Hepatitis C Virus Replication

Inhibitor of CD59 Activity as an Adjunct to Antibody-Based Cancer Therapy

Summary A bacterial peptide fragment has been shown to facilitate antibody-mediated and complement-dependant cancer cytolysis. Applications Contact Maryanne Fenerjian, PhD Office of Technology Deve..

Application of Domain 4 of ILY for treatment and prevention of foreign ; pathogen infection

Summary Streptococcus intermedius intermedilysin (ILY) secreted by Streptococcus intermedius is a cholesterol-dependent cytolysin that shows the specific feature of hemolytic activity towards human ce..

Non-ATP competitive Inhibitors of Aurora Kinases: Selective and Potent Cancer Treatment

Small-molecule inhibitors of Chlamydia cell growth

Summary Small molecule inhibitors of CopN for the treatment of Chlamydia pneumoniae associated pneumonia and vascular disease. See Huang et al. Nature 01 Oct 2008. CopN is a member of a family of p..

Inhibitors of Cellular Necrosis III (thiadiazoles)

Inhibitors of Cellular Necrosis III (non-thiadiazoles)

Small molecule regulators of autophagy identified by an image-based high throughput screen

Summary Compounds for the induction of autophagy and screening methods for further identification of autophagy inducing compounds. Autophagy is a lysosome-dependent process whereby proteins or dama..

C16:1n7-palmitoleate: A novel lipid hormone as a diagnostic and therapeutic tool

Inhibition of Sirt$ for treatment of obesity and ehancing fat metabolism

Summary A method of screening for compounds that modulate SIRT4 fatty acid oxidation activity. SIRT4 is a mitochondrial protein that plays a central role in regulating amino acid stimulated insulin..

Dominant negative inhibitor of anthrax toxin

Breast cancer biomarker and drug target

Summary The invention provides a novel chloride channel protein found in human breast cancer cells. That protein, called Mat-8, serves as a useful diagnostic reagent for the detection of breast cancer..

Novel Synthetic Mechanism to b-Lactone and Analogs: Lead Compounds for the Treatment of Proteasome-Related Diseases

Summary Background: Proteasome inhibition offers considerable promise in the therapy of a number of types of diseases, such as cancer and neurodegenerative diseases. One such proteasome inhibtor, Velc..

Eotaxin: an Eosinophil Chemoattractant

Summary Investigators at Harvard Medical School have isolated and functionally characterized eotaxin, a novel mammalian chemokine that regulates migration of eosinophils, a class of leukocytes known t..

Methods for Improved Viability of Cells at Low Temperature

High-Throughput Synthetic Platform for Natural Product Analog Libraries

Summary Background: In small molecule drug development, researchers typically develop biased libraries in which all members share a particular characteristic, such as an ability to interact with a par..

Direct and Practical Synthetic Route to Pseudopterosins: Important Anti-Inflammatory, Anti-Pain, and Anti-Irritant Compounds

Identification of a Sequence Element from p53 that Signals for Mdm2-targeted Deg

Summary Research at Harvard University has led to a novel means of protecting the cell against oncogenic tumor formation. This invention provides compositions and methods for inhibiting degradation of..

A New p53 Cell-Based Assay

Summary Harvard researchers developed a reliable, high-throughput screening assay to identify activators and inhibitors of p53. This cell-based luminescence assay measures the level of a reporter gene..

Dominant negative inhibitor of anthrax toxin

Identification of Protein Ubiquitination Sites

Summary Protein ubiquitination is the most common of all postranslational modifications, and is a key process in the pathway of protein degradation. The present invention describes a method of identif..

SID Proteins Enable Gene Silencing by Systemic RNAi

Summary RNAi is an ancient gene regulatory mechanism that has been recently and nearly universally adapted to laboratory use to inhibit or knockdown expression of targeted genes. Gene targeting is usu..

Anti-Mitotic Eg5 Inhibitors for Treatment of Cancer and Inflammatory Disease

Summary Background: Molecules targeting mitosis and microtubule stability are important for the treatment of cancer. Unfortunately, the mechanism of action of these agents can cause undesirable toxici..

Col 2A promoter Cre transgenic mice

Summary Description: Modulating gene activity on chondrocytes Transgenic mice were generated in which the regulatory sequences for the Col2a1 gene were used to drive expression of Cre recombinase i..

Transgenic mouse model for neurodegenerative disease

Summary The laboratory of Dr. Li-Huei Tsai has developed a mouse model for Alzheimers disease. They created an indicuble transgenic (Tg) mouse line overexpressing GFP tagged p25. The overexpression is..

In Vivo Evolution of an RNA-Based Transcriptional Activator

Transgenic GFP-Rhodopsin Zebrafish Model System for Study of Retinal Disease

A Novel Class of Proteosome Inhibitors

Small Molecule Approaches to the Management of Macular Degeneration by Short-Circuiting the Visual Cycle

Proteasome-Mediated Degradation of RISC: Lead Target for Treatment of Long-Term Memory Disorders

Wnt1-Cre transgenic mouse model

A Novel Screening Method for Assessment of Psychopathologic Disorders

Treating Diseases Associated with Oxidative Stress through the Metalothioneine System

Microfluidic Eddies for Cell Trapping, Separation, and Concentration

Introduction Trapping individual live cells requires a balance between a trap strong enough to hold a swimming cell, and trap gentle enough not to disrupt or damage the cell. Current cell trapping met..

Cell and Microparticle Separator Employing Patterned Grooves

Introduction Microscale enrichment and separation are important for various research, biomedical, and industrial uses. Conventional means for these processes typically require specific labels— eith..

Methods and Compositions for Screening for Modulators of Parkinson’s Disease

Introduction Parkinson’s Disease (PD) pathogenesis has been linked to oxidative stress, mitochondrial dysfunction, aberrant proteolytic processes and dysfunctional immune surveillance. However the m..

Contrast Agent Corrections for PET-CT Scanners with Dual-Energy

Introduction Positron emission tomography (PET) is an imaging technique capable of creating threedimensional images of metabolic processes. Using radioactive metabolite tracers, this procedure functio..

Programmable Generation and Transport of Droplets on Microscale Surface Texture Ratchets

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications. Currently, many laboratory processes can be combined on a single chip commonly only mill..

Evanescent Wave Coupling Sensor for Shear/Pressure Measurement

Introduction Lower limb complications associated with diabetes include the development of plantar ulcers that can lead to infection and subsequent amputation. Several authors have postulated that shea..

MAGI-CCR5 Cells

Introduction Chemokines are a large family of chemotactic proteins, which regulate leukocyte activation and recruitment to sites of inflammation. Human chemokine receptor CCR-5 was shown to serve as a..

Recombinant AAV Vectors for Hepatic Gene Therapy

Introduction The liver is the target of a number of different viral infections and other disorders. Despite the impressive progress in biomedical sciences during the last decades, the therapy of many ..

Prosthesis to Photo-Stimulate Retinal Neurons for Sight Restoration

Introduction It is estimated that 1 million people in the United States and 40 million worldwide are legally blind. Approximately 25% of these cases are caused by inactive photoreceptors in the eye. M..

Needle Probe for Single and Two-Photon Determination of Human Retinal Health

Introduction Laser imaging of the retina is a well-developed field that has generated state-of-theart scanning laser ophthalmoscopes (SLOs). Autofluorescent materials have been developed that can imag..

A Rapid Microfluidic Immunoassay for Quantitative Measurement of Interactions among One or More Analytes

Introduction There is a need for rapid and versatile means to quantitatively measure binding interactions between analytes. Most conventional competitive assays are carried out in an ELISA format for ..

Biomarkers for Neurodegenerative Disorders

Introduction Neurodegenerative disorders (ND) such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and dementia with Lewy body (DLB), are currently diagnosed by clinical presentations, lab..

A Microfluidic Device and Methodology for Rapid, Quantitative Determination of Analyte Concentration in a Fluid Sample

Advances in microfluidic technology are constantly opening doors to new and exciting applications, especially for biosensors and environmental monitoring. One recent area of interest is point-of-care ..

Platelet Clotting Force Array

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, such as point-of-care diagnostic devices. These microscale diagnostic platforms will ena..

Technique for Detecting Loose Arthroplasty Components

Ultrasonic Probe for Determination of Kidney Stone Size

Non-toxic protocol to establish paraoxonase 1 (PON1) status

Introduction Paraoxonase 1 (PON1) is a member of a three-gene family localized on human chromosome 7. Due to its role in the metabolism of both lipids and organophosphorus (OP) compounds, genetic var..

Cardiac PET/CT and SPECT/CT automated attenuation correction quality control alignment

An optical spectroscopic approach for quantifying Hb/Mb ratio noninvasively noninvasively

Introduction Impaired blood flow and mitochondrial defects are involved in a wide variety of metabolic and degenerative diseases. The inability to quantify tissue hemoglobin (Hb) content presents a si..

Hybrid Cochlear Implants

Introduction Hearing loss is a common problem for aging seniors and people who work long hours in noisy environments. The majority of people with hearing loss have sensory-neural impairments due to dy..

Signal Amplification Method for SPR-based Chemical Detection

Introduction Surface plasma resonance (SPR) is a general spectroscopic method for sensing refractive index changes near the surface of a metal film. Its sensitivity to these changes provides a versati..

An Efficient Mammalian DNA Insulator Element

Introduction A boundary element (MINE for myc insulator element) has been discovered which efficiently functions as both an enhancer blocker as well as a barrier element in chromosomal DNA. Technology..

Biomarkers for Cardiovascular Disease

Oxidation Resistant form of Apolipoprotein A-I

Introduction High density lipoprotein (HDL) protects against atherosclerosis by removing cholesterol from cells of the artery wall. Apolipoprotein A-I (apoA-I), which accounts for ~70% of the total pr..

A Monoclonal Antibody Specific for Apolipoprotein A

Introduction Diagnosing the risk of developing heart disease is commonly done by measuring levels of cholesterol, HDLs, LDLs, and triglycerides. Lipoprotein A is an additional marker that is gaining s..

Fabrication of Gold Nanocages and Cubic Nanoframes for Biomedical Treatment through Etching Nanoboxes

Introduction Because of their small sizes and unique properties, nanomaterials are finding widespread use in studying complex biological systems. Gold nanostructures have been the subject of intensive..

Automated Yeast Pedigree Analysis

Introduction Saccharomyces cerevisiae, or budding yeast, is a single-cell eukaryotic microorganism that commonly is used by biologists to study genetics. Yeast pedigree analysis is used to study genom..

Anti-Pseudomonas Biofilm Agents

Introduction Pseudomonas aeruginosa infection is a serious problem in patients hospitalized with cancer, cystic fibrosis, and burns. This opportunistic pathogen causes infections that are difficult to..

The Multiple Drug Resistance Gene, Polymorphisms, and uses Thereof

Introduction Multiple drug resistance is a well-documented phenomenon and critical problem in the treatment of various diseases including cancer and HIV. While there are many mechanisms leading to mul..

Pulsation-Induced Thyroid Strain Imaging

Introduction Thyroid nodules are swellings that develop on the thyroid gland. Often they are benign, but in some cases they are cancerous. Making this distinction is important because 19-36% of the ge..

Localization Wire for Surgical Excision of Breast Lesions

Introduction With the introduction of screening mammography, the median tumor size has decreased considerably, and approximately half of breast cancers in surgical practice are non palpable and amenab..

Therapeutic Methods Based on Characterized BRCA1 and BRCA2 Proteins

Introduction Over a lifetime, it is estimated that women who have mutations in the BRCA1 gene or BRCA2 gene have up to a 55% and 25% risk of developing ovarian cancer, respectively. These rates are si..

Surface Receptor Antigen Vaccines

Introduction The invention relates to DNA vaccines, or vaccines containing molecules encoded by such DNA, for the induction of specific, sustained high titer antibody responses. More specifically, the..

Improved use of Recombinant Viruses for Liver Regeneration

METHODS AND COMPOSITIONS FOR DIAGNOSING HEPATOCELLULAR CARCINOMA

Introduction Currently, it is difficult to diagnose HCC. Methods employed generally rely on imaging techniques such as MRI, CT, and ultrasound and are of little use in detecting the disease in its ear..

Novel Thymidylate Synthase Mutants For Treating Chemotherapy-induced Mucositis and Other Chemotherapy Side Effects

Introduction 35 novel thymidylate synthase (TS) mutants have been generated by random mutagenesis. These mutants are different from wild type TS in single, double, or multiple mutations, which are loc..

Magnetic Nanoparticle-conjugates as Contrast Agents or Drug Carriers for Cancer Diagnosis and Therapeutics

Introduction There is a growing interest in developing nanoparticle-based targeting agents for tumor diagnostics and therapeutics. Using these agents, tumors and diseased tissues can be detected at th..

Porphyromonas gingivalis LPS as an Immune Modulator

Introduction Vaccines often require the use of adjuvants, immune modulating substances, to generate adequate immune responses for the prevention or treatment of disease. Current adjuvant systems often..

Tumor-cell Specific Adenoviral Vector Replication and Gene Expression

Introduction One of the greatest challenges in tumor gene therapy is to deliver an anti-tumor vector to every cell in the primary tumor and all distant metastases. This includes cells in the center of..

Diagnosis and Treatment of Malignancy

Introduction Novel methods for the detection, monitoring, treatment, and prevention of malignancies have been developed that are based on the body’s own immune response to cell surface markers on ca..

Compositions and Methods for Detecting Pancreatic Cancer

Introduction Pancreatic cancer is a highly lethal disease; it is highly invasive and unresponsive to standard chemotherapy. The discovery of genes that cause familial forms of cancers has often shed l..

Molecules and Methods for the Treatment and Detection of Cancer

Introduction Approximately 30,000 women are diagnosed with ovarian cancer yearly in the United States, and only about 50% of those diagnosed will survive the disease. Early, accurate prognosis of ovar..

Mouse Model of Gastrointestinal Stromal Tumor (GIST)

Introduction Recent developments have firmly established the important role of receptor tyrosine kinases in human cancer. Kit is a receptor tyrosine kinase and its role as a cellular oncogene has been..

Construction and Use of Mutant Herpes Thymidine Kinase Genes in Cancer Therapy

Introduction In addition to surgery, many cancers are also treated with a combination of therapies involving cytotoxic chemotherapeutic drugs and/or radiation therapy. However, disadvantages to this m..

Methods and Compositions to Quantitate Thyroglobulin in Human Blood Specimens

Introduction Thyroglobulin is a marker of thyroid cancer. The presence of thyroglobulin in the plasma/serum of patients indicates functioning thyroid tissue. Following surgery and treatment with radio..

Use of the Type 3 Adenylyl Cyclase as a Drug Target Site to Treat Obesity

Introduction Obesity in the U.S. has increased dramatically in the past two decades. Although intensive efforts have been devoted to anti-obesity therapy, the percentage of obese individuals in the Un..

Use of Contrast Agents to Increase the Effectiveness of High Intensity Focused Ultrasound Therapy

Introduction Contrast agents, used to make structures of interest stand out from the background, have been successfully employed to enhance diagnostic imaging in magnetic resonance imaging (MRI), and..

Treatment of African Sleeping Sickness and Chagas Disease

Introduction African human trypanosomiasis is caused by the protozoan parasites Trypanosoma brucei which is transmitted through the bite of tsetse flies. Ultimately the trypanosomes cross the blood-br..

Transgenic Mice Expressing Human Myeloperoxidase

Introduction Myeloperoxidase (MPO) co-localizes with macrophages in the human artery wall, and its characteristic oxidation products have been detected in atherosclerotic lesions. Thus, oxidants produ..

A Microfluidic Device and Methodology for Rapid, Quantitative Determination of Analyte Concentration in a Fluid Sample

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, especially for biosensors and environmental monitoring. One recent area of interest is p..

A Novel Diagnostic Test for Atherosclerosis and Clinically Active Coronary Artery Disease

Introduction Low levels of high density lipoprotein (HDL) are associated with a greatly increased risk of coronary artery disease (CAD). Evidence indicates that HDL protects against atherosclerosis by..

Warfarin Dosing and Genetic Variation

Introduction Warfarin is an anticoagulant used to prevent the blood from forming dangerous clots that could result in stroke. Determining the most effective and safest dose for each patient is extreme..

Phospholipid Transfer Protein, a Regulator of Cholesterol

Introduction The level of cholesterol in the blood is an important risk factor for atherosclerosis and coronary artery disease (CAD) which can eventually lead to heart attack or stroke. Cholesterol is..

Targeting Drugs to the Lymph Nodes for HIV and Cancer Therapies

Introduction HIV patients are currently treated using “HAART,” a highly active anti-retroviral therapy in which a plethora of drugs are administered to patients. This therapy is effective in reduc..

Methods of treating pulmonary disease using acetazolamide and structurally related derivatives

Introduction Alveolar hypoxia, as occurs with chronic lung diseases or ascent to high altitude, results in hypoxic pulmonary vasoconstriction (HPV). Exaggerated HPV causes high altitude pulmonary edem..

Treatment of Microvascular Angiopathies

Introduction Acute injuries to smaller blood vessels and subsequent dysfunction of the tissue in which the injured blood vessels are located (microvascular angiopathies) are common features of a varie..

Non-toxic protocol to establish paraoxonase 1 (PON1) status

An optical spectroscopic approach for quantifying Hb/Mb ratio noninvasively in muscle tissue

Automatic detection of vascular bleeding by Doppler ultrasound

Introduction Blood loss from extremity wounds is the number one cause of death in US soldiers in the battlefield today. Blood loss can lead to hemorrhagic shock within minutes if not properly treated ..

Platelet Clotting Force Array

Dopamine Beta-Hydroxylase/Galanin Transgenic Mice

Introduction Galanin is a neuropeptide with multiple inhibitory actions on neurotransmission and memory. In Alzheimer's disease (AD), increased galanin-containing fibers hyperinnervate cholinergic neu..

Neuropeptide Y Y5 Receptor Knock-out mice

Introduction Neuropeptide Y (NPY), a 36-amino-acid neuromodulator abundantly expressed in the brain, has been implicated in the regulation of food intake and body weight. Pharmacological data suggest ..

Human Islet Amyloid Polypeptide transgenic mice

Introduction Amyloid deposits are found in the pancreatic islets of most individuals with non-insulindependent diabetes mellitus (NIDDM). The major component of islet amyloid is a 37-amino acid peptid..

cDNA clone Encoding a β1-subunit of a Brain Sodium Channel

Introduction The voltage-gated sodium channels that are responsible for action potential generation in central neurons are important targets for the actions of antiepileptic drugs. These channels cons..

Small Fiber Biomaterials

Introduction Invariably implanted foreign materials, regardless of surface chemistry and composition, result in an encapsulation in soft tissue, a process known as the foreign body reaction (FBR). Thi..

Ultrasound Target Vessel Occlusion using Microbubbles

Introduction Ultrasonography is a noninvasive medical imaging technique, which utilizes ultrasonic waves in order to visualize soft tissue within the body. Advances in this technology have led to a th..

Pre-Surgical Cauterization during Minimally Invasive Endoscopic Procedures Using Ultrasound

Introduction Surgery is an essential tool in the treatment of many pathologies. Hundreds of thousands of surgical procedures are performed each year that result in the full or partial removal of organ..

PEO Coated IOL

Introduction Intraocular lenses (IOL) are well established in the area of ophthalmology, and are often used to replace a natural lens affected by cataracts or to compensate for refractive errors. IOL ..

Intraocular Drug Delivery System

Introduction 10 million intraocular lenses are implanted each year worldwide in which infection is a major concern. In order to prevent serious infections that can lead to blindness, antibiotic drops ..

Flexible Fiber-Optic Scanning Multiphoton or Harmonic Miniature Imaging Probe

Introduction Endoscopes are increasingly involved in performing common surgical procedures and in diagnosing cancer and other medical conditions. New technologies can demonstrate significant cost savi..

Angiogenic biomaterials

Introduction The failure of many implanted devices and materials is due to the lack of new blood vessel formation (vascularization) to the implant. This leads to sequestering and/or inflammation of th..

Directional Sensitive Shear/Pressure Using Fiber-Optic or Dielectric Waveguide Polarimetric Sensor

Preparation of porous hydroxyapatite scaffolds by combination of the gel-casting and polymer sponge methods

Introduction Typically, porous tissue engineering scaffolds for use in growing bone have failed to achieve the mechanical strength of bone. Conversely, it has been difficult to create scaffolds using ..

Polymer based bendloss waveguide sensor for shear and pressure measurement

A Novel Means of Measuring Mechanical Shear/Pressure Stress using Flexible Polymeric Sensor

Introduction Diabetes is a significant national health care priority and foot complications are one of the more serious considerations. More than 60,000 amputations of the lower extremities are perfor..

Biocompatible Non-fouling Materials with Active Functional Groups

Introduction As combination medical device/pharmaceutical products become more widespread, one big challenge is to find materials that are both biocompatible and chemically active. For example, it is ..

MOLECULAR ENCODING OF NUCLEIC ACID TEMPLATES FOR PCR AND SEQUENCE ANALYSIS

Introduction The polymerase chain reaction (PCR) allows multiple copies of selected DNA sequences to be produced from limited amounts of a DNA template. Reactions with limited amounts of template, how..

Method for Generating Human Retinal Neurons and Photoreceptors from Embryonic Stem Cells

Introduction The degeneration of neurons and photoreceptors in the retina occur in a number of disorders for which there are currently few therapies, including retinitis pigmentosa, age-related macula..

Use of CTLA4Ig for Improved Adenovirus-mediated Gene Therapy

Introduction Gene therapy holds great promise for the treatment of many diseases that now lack specific therapies. The primary goal of gene therapy is to introduce additional genetic elements or to re..

Intraoperative Dosimetry for Prostate Brachytherapy using Transrectal Ultrasound and X-Ray Fluoroscopy

Introduction Prostate Brachytherapy is a method of treating prostate cancer by strategically placing small, radioactive “seeds” into the prostate. During a typical treatment, about one hundred see..

Inducible Mutagenesis of Target Genes

Introduction The B cell alters its genome during differentiation, and under environmental signals. The plasma cell DNA is rearranged during the cell’s development from a B cell to create the antibod..

Method for Generating Human Retinal Neurons and Phoreceptors from Embryonic Stem Cells

Introduction There are a number of degenerative conditions, both inherited and acquired, that affect the retina and lead to blindness. Retinal photoreceptors degenerate from inherited conditions, such..

Methods and compositions for prevention or treatment of inflammatory-related diseases and disorders

Introduction Leukocyte adhesion and migration plays a key role in response to inflammation and infection. This process is a well-orchestrated series of adhesion, de-adhesion, signaling and cytoskeleta..

Methods of Inhibition of Stenosis and/or Sclerosis of the Aortic Valve

Introduction Calcific aortic valve disease (CAVD), ranging in severity from sclerosis to stenosis, is characterized by irregular areas of increased thickening on the aortic side of the valve. Until re..

Direct Phase-based Strain Estimator for Ultrasound Tissue Elasticity Imaging

Introduction Strain estimation is used when studying and diagnosing tissues that have hardened from disease. Tumors are typical examples of such tissues. Information about stiffness and elasticity obt..

Method to inhibit ectopic calcification by blocking phosphate uptake

Introduction Vascular calcification is associated with cardiovascular morbidity and mortality. A number of diseases are associated with ectopic calcification including calcific aortic stenosis, idiopa..

Materials and Methods for Mimicking Natural Focus Shifts in Viewers Using Variable-Focus, Narrow-Depth-of-Focus Displays

Introduction Current stereographic displays, especially Head Mounted Displays (HMDs), tend to cause profound eye fatigue often accompanied by headache. Research suggests that this eye fatigue is, in p..

Gold Vision

Solubility Enhancing Fusion Proteins

Introduction Recombinant proteins having therapeutic, diagnostic or any other commercial or research applications are produced by expression in a host cell. However these proteins of interest are ofte..

Improved use of Recombinant Viruses for Liver Regeneration

Laser Treatment of Acne Using Scanning Fiber Delivery

Introduction Acne is a problem that affects approximately 85% of all teenagers. The typical drug treatments, such as isotretinoin, are known to have many risks and side effects. Many other over the co..

Safe last step

Introduction A common cause of injury among orchard workers in Washington state occurs when the user dismounts the ladder. The user often cannot accurately gauge the last step of the ladder because th..

Ribozymes for Treating Hepatitis C

Introduction Hepatitis C virus (HCV) is one of the main causes of liver-associated morbidity and mortality, and is the leading indication for liver transplantation in the western world. It is estimate..

Colorimetric imaging for abdominal organs

Introduction Color, a significant aspect of visual input, can provide medically relevant information. Visual input is critically important to surgeons as it provides 70% of the sensory input. Accurate..

Method for Determining the Phase Advancement Required for Recruited Elements in High Intensity Focused Ultrasound

Introduction High intensity focused ultrasound (HIFU) is used for medical diagnostics and for hyperthermia treatment of tumors. At the target area, very high temperatures are induced which cause coagu..

A Method and Design for Performing Rapid Parallel Microfluidic Molecular Affinity Assays

Introduction Point-of-care diagnostic testing, or testing performed at the patient bedside, allows physicians to diagnose patients more rapidly than traditional laboratory-based testing. Rapid results..

Method to detect, identify, and monitor kidney stone comminution in shock wave lithotripsy

Introduction Shock wave lithotripsy (SWL) is a method used to physically disrupt kidney stones using focused acoustic shock waves. When pulverized, the stones are then small enough to pass naturally f..

Method to Detect and Monitor Internal Hemorrhaging

Introduction In severe trauma cases, there can exist internal bleeding that may be difficult to detect, monitor, and treat. One method for the non-invasive treatment of hemorrhaging is the use of High..

Respiratory Detection System (RDS)

A Microfluidic Device and Methodology for Rapid, Quantitative Determination of Analyte Concentration in a Fluid Sample

Optical Measure of Cellular Oxygenation during Cardiac Surgery

Introduction The ability to determine intracellular oxygenation in muscle is useful in physiology, pathology, and in applied clinical areas such as cardiac surgery. The availability of invivo, real-ti..

Construction of Tissue Microarrays from Needle Biopsies

Simple, fast technique for re-embedding. Any experienced technician can use this method without special training or additional materials or instruments. Description Tissue microarray (TMA) techn..

Veterinary Ultrasound Video

Training video describing the use of ultrasound on dogs, complete with precise labelling of organs and structures and expert narration. Description This video represents a significant advance ..

Elite Medicinal Plants

Guelph researchers have developed a method to produced standardized, elite medicinal plants with high yields of active ingredients. Major problems with existing methods to produce medicinal plants are..

Automated Solid-Phase Analytical Derivatization in Minutes

This innovative McMaster device is the first to integrate an autosampler and analytical column enabling sample isolation, analytical derivatization and instrument analysis via high pressure liquid chr..

Radiation Triage Mask

A facial mask device to be used by First Responders that will rapidly determine who has/has not been exposed to radiation, what radioisotope at what does. This device, that detects alpha, beta and gam..

Engineered Burkholderia for Bioremediation

A non-pathogenic strain of Burkholderia provides tremendous potential as a bioremediation agent particularly for degradation of PCBs or for sites with high TCE concentrations. Background The inte..

A Secreted Therapeutic and Drug Discovery Target for Early Stage Osteoarthritis

A diagnostic and therapeutic secreted target protein that is upregulated in a subset of human patients with OA. It is a strong regulatory candidate for the transformation of maintenance chondrocytes i..

Non-Transgenic Rodent Model For Alzheimer’s Disease and Cerebral Ischemia

A non-transgenic, adult onset rodent model for Alzheimer’s disease and stroke. Background Alzheimer’s disease is a gradual progressive dementia affecting both cognition and behavior. It is ch..

Novel Peptide Therapeutics for Bone Regeneration

A suite of proprietary collagen-binding peptides derived from bone sialoprotein (BSP) that are effective in promoting bone repair and regeneration. Background The worldwide orthopedic industry is..

Murine Mammary Carcinoma Cell Line C3L5

A highly metastatic murine breast cancer cell line that provides an excellent mouse model for fundamental as well as therapeutic studies of human breast cancer metastasis. Background Cancer anima..

New Powerful Tool for Monitoring of Kinase Activity

A powerful technology for the simultaneous monitoring of protein kinase activities in cell and tissue extracts using a multiplexed electrochemical assay Background In the cellular signaling netwo..

A FUNCTIONAL FOOD WITH INDICATIONS FOR PEPTIC ULCERS

BACKGROUND 1 in 10 people are affected by peptic ulcers over the course of their lifetime. Incidence of the condition is set to increase as the population ages. Current treatment relies on combination..

SPINAL DISC NUCLEUS REPLACEMENT

BACKGROUND In the last 10 years commercial interest in treatment of spinal degeneration in relation to back pain has increased with a large number of devices competing in a market estimated to be wort..

Gene Tests for Diagnostics of Psychiatric Disorders

The Invention We suggest two novel gene tests for psychiatric disorders: 1.Diagnostics of susceptibility to schizophrenia, based on single nucleotide polymorphism (SNPs) of the golli myelin basic ..

Novel anti cancer drug for the treatment of Brain

The researchers at Tel Aviv University and Perrigo Pharmaceuticals have developed a platform technology (the Rotem Platform) enabling the development of potent anti cancer drugs based on the chemical ..

Collaboration/Licence Opportunity PAEDIATRIC ANAESTHESIA RE-BREATHING APPARATUS

BACKGROUND In the normal Jackson-Rees system that is used to provide anaesthetic gas to a patient, one part of the apparatus connects to an open tailed reservoir bag. This bag expands and contracts in..

TUMOUR VASCULAR TARGETING AGENTS

A new pharmacophore for selective targeting of tumour blood-supply BACKGROUND Cancer is a huge killer, responsible for more than 500,000 deaths in the US and 150,000 in the UK each year, thus making n..

OPTICIN A TREATMENT FOR CANCER AND ANGIOGENESIS

BACKGROUND Opticin is a protein present in the eye (in the vitreous humour) and was discovered at University of Manchester by Dr Paul Bishop. Uniquely Opticin has been found to exhibit both cytotoxic ..

NOVEL TISSUE MARKER FOR STRATIFYING

BACKGROUND Research at the University of Manchester has identified a new tissue marker with potential use in the stratification of breast cancer patient groups and improved targeting of treatment for ..

SPINAL DISC NUCLEUS REPLACEMENT

PRODUCTION OF NOVEL HUMAN COLLAGENS

BACKGROUND A powerful new platform technology for the production of human collagens is being developed in the Kadler Centre for Cell-Matrix Research within the Department of Life Sciences at the Unive..

ENZYME-RESPONSIVE POLYMER HYDROGELS

BACKGROUND Biomaterials, either natural or synthetic, can be used to replace tissue, organ or body function for a period of time either for permanent implantation (heart valves), long-term application..

Embryonic Stem Cell Isolation and Expansion.

Background: Ageing populations coupled with failings in current drug based therapies are driving the quest for new treatments and methods of disease management. One of the most promising advances tow..

mapping and quantifying the contribution of elements to the overall performance of the system they compose

PR-Domain Containing Nucleic Acids, Polypeptides, Antibodies and Methods

BCL-G Polypeptides, Encoding Nucleic Acids and Methods of Use

Novel TRAF Family Proteins

Compositions and Methods for Modulating Bone Mineral Deposition

CARD Proteins Involved in Cell Death Regulation

Nucleic Acid Encoding Proteins Involved in Protein Degradation, Products and Methods Related Thereto

Heart Homing Peptides and Methods of Using Same

A Method for Determining the Prognosis of Cancer Patients by Measuring Levels of BAG Expression

A Method for Determining the Prognosis of Cancer Patients by Measuring Levels of BAG Expression 10/030,497

Highly Active Alkaline Phosphatase

NG2/HM Proteoglycan-Binding Peptides that Home to Angiogenic Vasculature and Related Methods

Methods for Inhibiting Tumor Metastasis, and Peptides Useful Therefor

A beta-1-6-N-acetylglucosaminyltransferase that Forms Core 2, Core 4 and I Branches

Methods for using Anti-avb, Integrin Antibody Antagonists

Proapoptotic Peptides, Dependence Polypeptides and Methods of Use

Novel Bag Proteins and Nucleic Acid Molecules Encoding Them

NGR Receptor and Methods of Identifying Tumor Homing Molecules that Home to Angiogenic Vasculature Using Same

Methods of Identifying Lung Homing Molecules Using Membrane Dipeptidase

Methods of Identifying Lung Homing Molecules Using Membrane Dipeptidase 6,174,687; 6,232,287; 6,933,281; 6,784,153; 6,610,651;

Sulfotransferase for HNK-1 Glycan

Novel Polypeptides

Novel Polypeptide

Integrin Ligand Dissociators

Anti-Bax Inhibitor Protein Antibodies

Trophinin and Trophinin-Assisting Proteins and Methods to Inhibit Implantation

Nucleic Acid Encoding a Family of Acetyl-Coenzyme-A Transporter Proteins, and Products Related Thereto

Antithrombotic Agents and Methods of Use

Methods of Inhibiting Angiogenesis and Ameliorating Cancer by Using Superfibronectin

Thryroid Hormone Receptor

Methods of Inhibiting Cancer by Using Superfibronectin-Generating Compounds

Methods of Inhibiting Cancer by Using Superfibronectin-Generating Compounds 6,475,488; 5,922,676

Methods of Modulating Radical Formation by Mutant CuZnSOD Enzymes

Tumor Homing Molecules, Conjugates Derived Therefrom and Methods of Using Same

Targeted Therapeutic or Diagnostic Agents and Methods of Making and Using Same

Structural Mimics of RGD-Binding Sites

Molecules that Home to a Selected Organ or Tissue In Vivo and Methods of Identifying Same

Method of Identifying Molecules that Home to a Selected Organ or In Vivo

Method of Identifying Molecules that Home to a Selected Organ or In Vivo 6,068,829; 7,018,615; 5,622,699; 7,341,710; 6,296,832; 6,306,365

Cancer-Associated MAR Binding Protein

Isolated Nucleic Acid Molecules which Hybridize to Polysialyl Transferases

Structural Mimics of RGD-Binding Sites

PR Domain Peptides

PR Domain Peptides 6,069,231; 5,811,304; 6,323,335; 6,468,985; 5,831,008

CD40 Associated Proteins

CD40 Associated Proteins 6,265,556; 6,172,187

FAS Associated Proteins

FAS Associated Proteins 5,876,939; 5,747,245; 5,632,994

Methods of Sensitizing Tumor Cells With Adenovirus E1A

Methods of Sensitizing Tumor Cells With Adenovirus E1A 5,776,743; 6,100,243; 6,544,955

Trophin and Trophinin-Assisting Proteins

Trophin and Trophinin-Assisting Proteins 5,910,451; 5,880,267; 5,858,360; 5,599,918; 5,654,145

E-Selectin-Dependent Cell Adhesion Antagonists

Novel Integrin-Binding Peptides

Novel Integrin-Binding Peptides 5,536,814; 7,067,619; 6,177,542; 5,981,478; 5,627,263

Expression of the Developmental I Antigen by a cloned Human cDNA Encoding a Member of a b-1, 6-N- Acetylglucosaminyltransferase Gene Family

Soluble TGF-Beta-Binding Endoglin Polypeptides and Homodimers

Method of Inhibiting Replication of Hyperproliferative Cells

A Matrix-Associating DNA-Binding Protein, Nucleic Acids Encoding the same and Methods of Detecting the Nucleic Acids

Decorin Fragments and Methods of Inhibiting Cell Regulatory Factors

Recombinant Calf Intestinal Alkaline Phosphatase

Localized Drug Delivery to Ablate Fat Tissue

Researchers at the University of Michigan we have developed a novel drug delivery application, the ablation of fat tissue by the sustained, localized release of anti-fat drugs. The central premise of ..

A Novel beta-1-6 N-Acetylglucosaminyltransferase, Its Acceptor Molecule, Leukosialin, and a Method for cloning Proteins having Enzymatic Activity

A Novel beta-1-6 N-Acetylglucosaminyltransferase, Its Acceptor Molecule, Leukosialin, and a Method for cloning Proteins having Enzymatic Activity 5,629,291; 5,837,813; 5,747,452

Fibronectin Binding Sites and Methods of Modulating Fibronectin Extracellular Matrix Assembly

Fibronectin Binding Sites and Methods of Modulating Fibronectin Extracellular Matrix Assembly 5,658,778; 5,624,832; 5,360,733; 5,684,134

Novel Retinoid X Receptor Heterodimers and Methods of Use

Novel Retinoid X Receptor Heterodimers and Methods of Use 7,098,310; 7,026,125

Method and Composition for Treating Thrombosis

Method and Composition for Treating Thrombosis 5,672,585; 6,521,594; 6,013,625; 5,648,330; 5,612,311; 6,395,873

Inhibitors of Cell Regulatory Factors

Inhibitors of Cell Regulatory Factors 5,583,103; 6,436,900; 6,509,314; 6,277,812

Merosin, Nucleic Acids Encoding Fragments and Uses Thereof (Heteromeric Variants of Laminin Like Proteins)

Merosin, Nucleic Acids Encoding Fragments and Uses Thereof (Heteromeric Variants of Laminin Like Proteins) 5,444,158; 5,872,231; 5,837,496; 5,624,905

T-Cadherin Adhesion Molecule

Method for Detection of Fibronectin Receptor Ligands

Polypeptides Encoding Transcriptional Activators and Uses Thereof

Hydrophobic Attachment Site for Adhesion Peptides.

Hydrophobic Attachment Site for Adhesion Peptides 5,760,176; 5,120,829; 5,587,456; 5,591,822

Inhibiting Transforming Growth Factor Beta to Prevent Accumulation of Extracellular Matrix

Antibodies to Integrins

Retinoic Acid Receptor e (RAREe)

Cooperative Combinations of Ligands Contained within a Matrix

Suppression of Cell Proliferation by Decorin

Methods for Modifying the Binding of Cell Adhesion Receptors

Inhibition of Cell Migration with Synthetic Peptides

Conformationally Stabilized Cell Adhesion Peptides

Conformationally Stabilized Cell Adhesion Peptides There are 8 numbers 7,030,213; 6,020,460; 5,906,975; 5,985,827; 5,880,092; 5,981,468; 5,827,821; 6,353,090

Isolation and Use of Receptors Binding to a Peptide Column

Isolation and Use of Fibronectin Receptor

Peptides in Cell Detachment and Aggregation

Tetrapeptide [RGD]

Tetrapeptide [RGD] One more number 5,916,875

An Inhibitor of Anti-Apoptotic Proteins Compound E10

Compositions And Methods Related to Clan CE smallpox cysteine protease K7L (I7L)

Compounds that Modulate Insulin Promoter Activity

Inhibitors of Antigen Receptor-Induced NF-kB Activation

Chemical Inhibitors of BFL-1 and Related Methods

Novel Proapoptotic Compounds for the Treatment of Cancer

Methods and Compositions Related to Terminal Arginine Peptides

Regulation of RIZ1 Histone Methyltransferase and RIZ1 Target Genes by Diet in Cancer Prevention

Dual Antagonists of Protein Interactions

Combination of Doxycycline, Selenium and Zinc that Retards Aging

SMIPs: Small Molecule Inhibitors of p27 Depletion in Cancers and Other Proliferative Diseases

Novel M2 Inhibitors against Influenza A Virus

Tissue-Nonspecific Alkaline Phosphatase (TNAP) Activators and Uses Thereof

Bladder Tumor-Targeting Peptide and Use Thereof

HES6 as a Marker of Pancreatic Endocrine Stem Cells

Use of Activating Transcription Factor-2 (ATF2) for Detecting Skin Cancer

Bi-dentate JNK Inhibitors

Beta-Lactone Compounds

Methods And Compounds For Regulating Apoptosis (relates to Bfl-1)

VHR Protein Tyrosine Phosphatase Inhibitors, Compositions and Methods of Use

Methods for Treating Leukemia and Myelodysplastic Syndrome and Methods for Identifying Agents for Treating

Pyridines and Pyrimidines as Kinase Inhibitors

ZNF206: A Novel Regulator of Embryonic Stem Cell Self-Renewal and Pluripotency

Novel Inhibitors of Alkaline Phosphatase Suppress Vascular Smooth Muscle Cell Calcification

Inhibitors of Chaperone HSP70

Arylthioacetamide Carboxylate Derivatives as FKBP Inhibitors for the Treatment of Neurological Diseases

Targeting Host Proteinases as a Therapeutic Strategy Against Viral and Bacterial Pathogens

Hybrid Automated/ Curated/ Peer-Reviewed Publication System

Compositions and Methods of Treatment of Colorectal Cancer

High Affinity EPHB Receptor Binding Compounds and Methods of Use Thereof

Chemical Inhibitor of Bcl-2 Family Proteins as Potential Treatment of Disease

Method for Diagnosing Cancer of Prostate

Methods and Compositions Related to Clot Binding Compounds

Biomarkers of Neurogenerative Disease

Methods and Compositions Related to Targeting Wounds, Regenerating Tissue, and Tumors

Compositions And Methods For Inhibiting Growth And Metastasis Of Melanoma [relates to ATF2 and ATM activation and celastrol]

Inhibitors of Thapsigargin-Induced Cell Death [ER stress]

Appoptosin and Uses Thereof for Treating Neurodegenerative Disease and Cancer

Trophinin-Binding Peptides and Uses Thereof

Compositions and Methods for Treatment of Insulin-Resistance Diseases

Methods and Compositions for Targeting gC1qR

Compositions and Methods for Inhibiting Cell Migration

Neuroprotective Compositions and Methods

Methods Culture ,Production f Single Cell Populations ,f Human Embryonic, Stem Cells

Methods for Culture and Production of Single Cell Populations of Human Embryonic Stem Cells

Modulators of RNF5 and Uses Thereof

Methods Related to MMP26 Status as a Diagnostic and Prognostic Tool in Cancer Management

Methods and Compositions Related to Targeting Tumors and Wounds

Mammalian Extraembryonic Endoderm Cells and Methods of Isolation Thereof

Use of Cyclosporin A to Sensitize Resistant Cancer Cells to Death Receptor Ligands

R-Ras Activity in Vascular Regulation

Nucleic Acid Encoding Proteins Involved in Protein Degradation, Products and Methods Related Thereto

Lymphatic Zip Codes in Tumors and Pre-Malignant Lesions

Methods for Screening for Compounds that Modulate Insulin Promoter Activity

Inhibitors of Membrane Type-1 Matrix Metalloproteinase for the Treatment of Insulin-Dependent Diabetes Mellitus

Endometriosis Cell Targeting Peptides and Uses Thereof

Composition and Methods for Detection of Colorectal Cancer

Novel Antagonists of the Thioesterase Activity/Domain of Human Fatty Acid Synthase

Death Receptor Sensitizing Compounds and Methods of Use Therefor

Fusion Proteins and Methods of Cleavage of Such Proteins

Methods for the Inhibition of Neovascularization and Cancer Metastasis

Anxiolytic Treatment by Inhibition of a Polysialyltransferase

Screening Methods for Protein Kinase B Inhibitors Employing Virtual Docking Approaches and Compounds and Compositions Discovered Thereby

Homogeneous Neural Precursor Cells

EphB Receptor-Binding Peptides

Tissue-Non Specific Alkaline Phosphatase (TNAP): a Therapeutic Target for Arterial Calcification

Novel Heart Homing Peptides and Methods of Using Same

Inhibition of Lethal Factor Protease Activity From Anthrax Toxin

Uncharacterized ORF3 in SARS-Coronavirus is a Cyclic-AMP-Dependent Kinase and a Target for SARS Therapy

Inhibition of Bid-Induced Cell Death Using Small Organic Molecules

Functional Variant of Lymphoid Tyrosine Phosphatase is Associated with Autoimmune Disorders

Modulators of SHP2 Tyrosine Phosphatase and their Use in the Treatment of Body Weight Disorders

Compositions and Methods for Treatment of Disease Caused by Yersinia Spp. Infection

Compositions and Methods for Screening Pro-Apoptotic Compounds

Defined Media for Pluripotent Stem Cell Culture

Antimicrobial Carbohydrates and Methods of Using Same

Metadherin Polypeptides, Encoding Nucleic Acids and Methods of Use

Gab 1 Involvement in Glucose Homeostasis Regulation by Hepatocytes

A Method for Detectin Prognosis of Cancer

Inhibitors of Matrix Metalloproteinases to Treat Neurological Disorders

Treatment of Metabolic Syndrome to Treat Dementia

p16 Mediated Upregulation of NMDA Receptors

Molecules that Selectively Home to Vasculature of Pre-Malignant Dysplastic Lesions or Malgnancies

Molecules that Selectively Home to Vasculature of Pre-Malignant or Malignant Lesions of the Pancreas and Other Organs

Cytoplasmic Activity of Retinoid X Receptor and its Regulation by Ligands and Dimerization

Screening Assay for Agents that Alter Target of Rapamycin Activity

Use of Selective Labeling to Detect and Characterize Mol. Interactions by NMR Spectroscopy

Device and Method for Treating Restinosis

Use of Hepatitis B X-Interacting Protein (HBIXP) in Modulation of Apoptosis

Chimeric Constructs Between Cancer-Homing Peptides and Cell-Penetrating Peptides Coupled to Anticancer Drugs and/or Diagnostic Agents [CREKA]

Inhibition of ATF-2 Activity to Treat Cancer

Novel Agents that Modulate Eph Receptor Activity

Methods of Modulating Cell Death Based on the BIT-1/AES Regulatory Pathway

HMGN2 Peptides and Related Molecules that Selectively Home to Tumor Blood Vessels and Tumor Cells

Neuroprotective Synergy of Erythropoietin and Insulin-like Growth Factors

ATM Related Kinase ATX, Nucleic Acids Encoding Same and Methods of Use

Shp-2 Tyrosine Phosphatase and Embryonic Stem Cell Differentiation

Methods for Determining the Prognosis for Patients with a Prostate Neoplastic Condition

Inhibition of Fatty Acid Synthase by Beta-Lactones and Other Compounds for Inhibition of Cellular Proliferation (Orlistat)

Excitatory Glycine Receptors and Methods

Peptides That Home to Tumor Lymphatic Vasculature and Methods of Using Same

Breast Homing Peptides and Methods of Identifying Same Using Aminopeptidase P

Nucleic Acids Encoding Microbial SUMO Protease Homologs

Bacterial Bcl-2 Domain-Containing Polypeptides, Encoding Nucleic Acid Molecules, and Related Methods

Non-Apoptotic Forms of Cell Death and Methods of Modulation

CARD-Domain Containing Polypeptides, Encoding Nucleic Acids, and Methods of Use

Apoptosis Modulator Bcl-B and Methods for Making and Using Same

Nucleic Acid Molecule Encoding a PANG6 Polypeptide

Methods of Differentiating and Protecting Cellsby Modulating the P38/MEF2 Pathway

Death Domain Proteins

Diagnosis of Human Glycosylation Disorders

Chimeric Prostate-homing Peptides with Pro-apoptotic Activity

Methods for Determining the Prognosis for Cancer Patients Using TUCAN

Device & Method for In-depth Activation of Genetically Targeted Excitable Cells with High Spatial Resolution Using Two-Photon Excitation with a Laser

Background: Recently light-assisted activation of selected groups (expressing the same gene) of electrically excitable cells such as neurons has been made possible with high temporal precision by int..

Animal Model (Rat) of Keratoconjunctivitis Sicca (Dry Eye) by Denervating the Trigeminal Nerve and Using the Whisking Response to Localize the Lesion

Background: Dry eye syndrome (keratoconjunctivitis sicca [KCS]) is one of the most common diseases of the eye. Technology: Denervation of the trigeminal innervation to the cornea resulted in signi..

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