Therapeutic Use
PROBLEM TO BE SOLVED: To provide a method for treating neurodegenerative diseases such as multiple sclerosis by administering an EphA4 antagonist or an EphA4 ligand antagonist to a subject in need. ; SOLUTION: The antagonist may be a soluble EphA4 or EphA4-binding ephrin or their functional variants such as an EphA4-Fc or an ephrin A5-Fc. The antagonist may be a nucleic acid, polypeptide, peptide or organic molecule that binds to EphA4 or an EphA4-ligand or a nuclei acid encoding EphA4 or the EphA4-ligand and downregulates its activity. Combination therapies are also disclosed. ; COPYRIGHT: (C)2011,JPO&INPITPatents:
JP 2,010,285,413
Inventor(s): TURNLEY ANN MAREE; BUTZKUEVEN HELMUT
Type of Offer: Sale
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