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Genotypic tumor progression classifier and predictor

Actively dividing tumors appear to progress to a life threatening condition more rapidly than slowly dividing tumors. Assessing actively dividing tumors currently involves a manual assessment of the number of mitotic cells in a histological slide prepared from the tumor and assessed by a trained pat...
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Method of producing recombinant biological products

A method of producing a recombinant biological product, which method employs a mammalian producer cell culture, comprises the steps of generating a biomass of mammalian producer during an initial phase of cell culture, and causing an increase in a level of one or more of the miRNA molecules of Table...
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Nanoparticle clusters and methods for forming same

A method for providing nanoparticle clusters of controlled dimensions is described. The method involves an activation of individual nanoparticles and the subsequent interaction between activated particles to form a cluster....
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Specimen Gathering Device and Method of Use

This is the only DNA gathering device of its kind. It allows the user to simply and effectively gather forensic evidence, without waiting for the sample to dry, or any extra steps to ensure the DNA sample does not become contaminated or degrade. It also can be stored at room temperature, without th...
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Tobacco-based Nicotine Aerosol Generation System

The invention relates to devices and methods for delivering nicotine and/or other alkaloids from tobacco, other plants and other natural sources. More particularly, the invention relates to devices and methods for delivering an aerosol of nicotine to a user's lungs without combustion of the nicotine...
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Neuroactive Steroid Compositions and Methods of Use for Lowering Cholesterol

Methods for ameliorating a symptom associated with hypercholesterolemia, hyperlipidemia, or both in a subject. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a composition comprising pregnenolone (PG), allopregnanolone (ALLO), dehydroepiand...
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Compositions and Methods for the Treatment of Drug-induced Hand-foot Syndrome

The present invention provides methods of treating, ameliorating or preventing hand-foot syndrome in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a phosphodiesterase inhibitor....
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Use of SH2 STAT3/STAT1 Peptidomimetics as Anticancer Drugs

The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function. Peptidomimetics of the invention display selective inhibition of specific ...
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Niosome-hydrogel Drug Delivery System

Localized drug delivery systems are effective means to administer therapeutic concentrations and controlled release of drugs. A delivery system consisting of non-ionic surfactant vesicles (niosomes) packaged within a biodegradable, temperature and pH sensitive hydrogel network was developed. Drug be...
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Drug Delivery Device for Ovarian Cancer

A drug delivery device has been designed to directly deliver an agent to the ovaries through direct contact with the fallopian tubes. The device consists of three main components: a tubular inserter, a cylindrical chamber and a plunger. The device is a single-use applicator designed in a shape simil...
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Prognostic Tools to Predict the Efficacy of Drug Treatment Targeting Chromatin DNA Or Enzymes Acting on DNA

Disclosed are methods of predicting cell response to drug-based therapy using both PCR-Stop assays and real time PCR assays. Methods herein may be used for assessment of drug effect, evaluation of regimen suitability for a given patient, and/or for determination of an optimal drug dose. Also provide...
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Aqueous sustained-release drug delivery system for highly water-soluble electrolytic drugs

The present invention relates to liquid sustained release suspension dosage forms comprising ionized forms of water-soluble drugs. In particular, the invention encompasses a liquid form controlled release drug composition comprising a dispersed phase comprising an ion-exchange matrix drug complex co...
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Carbohydrate Functionalized Catanionic Surfactant Vesicles for Drug Delivery

Carbohydrate functionalized catanionic vesicles that include a glycoconjugate and/or peptidoconjugate for vaccination or drug delivery, methods for forming these, and methods of using these....
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Delivery of Therapeutic Agents Using Oligonucleotide-modified Nanoparticles As Carriers

Disclosed are drug delivery compositions comprising an oligonucleotide-modified nanoparticle and a therapeutic agent. Specifically, disclosed are compositions comprising a number of oligonucleotide molecules in a ratio to therapeutic agent molecules to allow a sufficient transportation of the therap...
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Potent Combinations of Zidovudine and Drugs That Select for the K65R Mutation in the Hiv Polymerase.

Combinations of antiretroviral nucleoside reverse transcriptase inhibitors, and methods for their use in treating retroviral infections, are provided. In one embodiment, the combinations include non-thymidine nucleoside antiretroviral agents, such as tenofovir-DF, abacavir, APD and DAPD, that select...
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Drug Conjugates

Conjugated compounds comprising a therapeutic or diagnostic agent linked to a substrate for a cell membrane transporter or receptor by lipophilic linker are provided....
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Aptamer-mediated Drug Release

The present invention relates to aptamer/drug conjugate complexes and the use of such complexes, together with a trigger compound, to inducibly release a drug. Through these complexes, the present invention provides a means for establishing a drug reservoir in a subject, whereby drug may be released...
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Modulation of Phospholipase D for the Treatment of the Acute and Chronic Effects of Ethanol

The present invention relates to methods of decreasing the negative effects of alcohol on behavior as well as inhibiting the toxic effects of alcohol, comprising administering, to a subject, an effective amount of an inhibitor of phospholipase D....
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Anti-drug Vaccines

The present invention relates to anti-drug vaccines based on conjugates between the drug and a non-immunogenic carrier protein. In preferred embodiments, it provides for anti-cocaine vaccines and their use to diminish the effects and/or use of cocaine in a subject....
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Methods, Devices, and Systems for On-demand Ultrasound-triggered Drug Delivery

Injectable or implantable drug delivery systems providing on-demand ultrasound- triggered drug release and methods for controlling the release of drug in a patient are provided herein. The on-demand drug delivery systems contain a drug depot and a drug encapsulated in an encapsulating material, wher...
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Novel anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof

The present invention provides methods for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject. The present invention further provides methods for treating and preventing atrial and ventricular cardiac arrhythmias, heart failure, and exercise-induced sudden cardiac dea...
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Novel Anti-arrythmic and Heart Failure Drugs That Target the Leak in the Ryanodine Receptor (ryr2)

The present invention provides novel 1,4-benzothiazepine intermediates and derivatives, methods for synthesizing same, and methods for assaying same. The present invention also provides methods for using these novel compounds to limit or prevent a decrease in the level of RyR2-bound FKBP12.6 in a su...
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Improved Cancer Drug Delivery Using Modified Transferrin

The invention provides modified Transferrin (Tf) molecules and conjugates of the Tf molecules with a therapeutic agent. The invention also provides methods of treating cancer wherein the therapeutic agents are chemotherapeutic agents. The modified Tf molecules improve the delivery of the conjugated ...
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Method of Engineering Polar Drug Particles with Surface-trapped Hydrofluoroalkane-philes

The invention relates to a method of engineering polar drug particles with surface-trapped hydrofluoroalkane-philes....
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Process for Identifying Drugs for Treating Gastroesophageal Reflux

Methods for identifying modulators of gastroesophageal smooth muscle relaxation include isolating various types of smooth muscle fibers from the stomach or esophagus and inducing the fibers to contract. The isolated and contracted fibers are used to screen test compounds for the compound's capacity ...
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Reservoir device for intraocular drug delivery

A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed t...
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Use of High-dose Oxazaphosphorine Drugs for Treating Immune Disorders

This disclosure relates, at least in part, to methods of eliminating adverse immune reactions in a subject in need thereof including those associated with autoimmune diseases, allergic reactions and transplant rejection, including administration of a lymphocytotoxic non-myeloablative amount of a oxa...
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Cullen 5 As a Regulator of Hsp90 Clients: a New Target for Drug Development

Cullin5 (Cul5) E3 ubiquitin ligase is shown to be linked with the heat shock protein 90 (Hsp90) chaperone complex. Hsp90 participates in the folding of its client proteins into their functional conformation. Many Hsp90 clients have been reported to be aberrantly expressed in a number of cancers. Cul...
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Degradable Hydrogel Compositions and Methods

This invention concerns an in situ biodegradable hydrogel drug delivery system in which the components are assembled in a manner that provides a mechanism for the timed cleavage of a particular amide bond in a covalently linked active agent or of the hydrogel structure....
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Polyarylates for Drug Delivery and Tissue Engineering

Biocompatible polyarylates of diphenol compounds and poly(alkylene oxide) dicarboxylic acids, articles formed therefrom and therapeutic uses are disclosed....
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Compositions and Methods for Treating Ophthalmic Diseases.

Degradable polymeric compositions containing water-insoluble drugs blended with copolymers of biocompatible diphenol compound monomer units with pendant carboxylic acid groups polymerized with biocompatible diphenol corn-pound monomer units with pendant carboxylic acid ester groups and poly(alkylene...
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Reconstituted Tumor Microenvironment for Anticancer Drug Development

Extracellular matrix bioscaffolds capable of supporting the formation and growth of tumors from tumor cells introduced thereto containing tumor associated macrophages and carcinoma-associated fibroblast-like cells cultured under conditions effective to provide a cellular matrix capable of supporting...
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Method for Treating And/or Preventing Drug Seeking Behavior

A dynorphin-A analog can be used for treatment, inhibition, and/or prevention of cocaine seeking behavior, and or the drug seeking behavior for a cocaine derivative or other structurally related substance. The dynorphin-A analog can be a cyclic dynorphin-A analog having sufficient systemic stability...
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Methods for Screening for Antibiotic Compounds

The present invention is a method for screening drugs for antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell....
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Compliant Composites for Application of Drug-eluting Coatings to Tissue Surfaces

A compliant composite for delivering a bioactive agent including a scaffolding material and a polymer coating that together can be attached to compliant tissue surfaces is disclosed, along with methods for constructing and applying these composites. In some embodiments, the composite further compris...
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Polyesters with Grafted Zwitterions

The invention relates to polymers, such as aliphatic polyesters, with grafted zwitterions More particularly, the invention relates to polyester-graft-phosphorylcholine polymers prepared by ring-opening polymerisation and click chemistry, compositions and products comprising same, and related methods...
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Drug delivery product and methods

The present invention provides a particulate delivery system comprising an extracted yeast cell wall comprising beta-glucan, a payload molecule and a payload trapping molecule. The invention further provides methods of making and methods of using the particulate delivery system....
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Method for Determining the Susceptibility of a Cell Strain to Drugs

The present invention relates to a method for determining the susceptibility of a cell strain to a compound intended for controlling the growth of said cell strain, comprising: - growing the cell strain in a first compound-free culture medium and in at least a second culture medium comprising the co...
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IGF1 for Myocardial Repair

Provided herein are methods for treating an individual having (suffering from) an acute myocardial infarction and drug eluting stents useful for treating such individuals. These methods include treating an individual by introducing, such as by surgically inserting, at a site of an acute coronary art...
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Method of Identifying Individuals At Risk of Thiopurine Drug Resistance and Intolerance

The invention relates to methods and kits for identifying individuals at risk of thiopurine drug intolerance based on detecting the presence of mutations in the TPMT gene promoter associated with thiopurine drug resistance or intolerance....
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A1 Adenosine Receptor Allosteric Enhancers

The present invention relates generally to chemical compounds and methods for their use and preparation. In particular, the invention relates to chemical compounds which may possess useful therapeutic activity for treating conditions where the promotion of angiogensis (blood vessel formation) is ben...
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Therapy and Prevention of Problem Drinking

The present invention provides methods for the therapy and prevention of problem drinking in alcohol-dependent and non-dependent subjects and those at risk of developing problem drinking behavior, and compositions of matter comprising oxytocin or an analog or derivative thereof or an agonist or part...
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Synthetic, Self Adjuvanting Vaccines

The present invention relates generally to the field of immunotherapy, and more particularly to immunomedicaments in the form of lipopeptides which induce an antibody response to drugs of dependence, and uses thereof in the treatment and prevention of drug addiction....
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Method of Eliciting Or Inducing an Immune Response

A method for eliciting or inducing an immune response in a human or animal subject, comprises administering to said subject a composition comprising an antigen and an adjuvant, wherein the composition is administered to the subject by the intra-lung route....
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Therapeutic Applications

The specification relates to methods for treating a neurodegenerative disease such as multiple sclerosis by administering to a subject in need an EphA4 antagonist or an EphA4 ligand antagonist. The antagonist may be a soluble EphA4 or EphA4-binding ephrin or a functional variant thereof such as an E...
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Therapeutic Use

PROBLEM TO BE SOLVED: To provide a method for treating neurodegenerative diseases such as multiple sclerosis by administering an EphA4 antagonist or an EphA4 ligand antagonist to a subject in need. ; SOLUTION: The antagonist may be a soluble EphA4 or EphA4-binding ephrin or their functional variants...
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Method for Controlling the Alertness of a Human Subject and a Light Source for Use in This Method

The invention relates to a method for controlling the alertness of a human subject and a light source for use in this method and use of a light source for this method. The method comprises exposure of a human subject during an exposure period to suitable light radiation without substantially influen...
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Therapeutic Peptides, Polypeptides Ans Nucleic Acid Sequences

Described are isolated peptides (GLGGGDLSV, SLNESQIKI, LMLPAVLQA and FTAEQLQRL) derived from portions of the Engrailed-2 (EN2) protein. Also described is their use in therapy, in particular in relation to the prevention and treatment of cancer....
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Therapeutic Aryl-am I Do-aryl Compounds and their Use

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-amido-aryl compounds of the following formula (for convenience, collectively referred to herein as "AAA compounds"), which, inter alia, are (selective) retinoic acid receptor a (RARa...
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Apparatus and Method for Influencing Fish Swimming Behaviour

An enclosure, method and apparatus for influencing the swimming behaviour of fish is disclosed. The enclosure defining a space within which the fish can swim, said enclosure having a series of light output members disposed along a path, said light output members being operable to provide a moving vi...
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Probe for Detecting a Particular Nucleic Acid Sequence

The invention relates to a detection molecule (triplex Molecular Beacon, tMB) for detecting a particular nucleic acid sequence, in particular for detecting a single nucleotide mismatch in a target nucleic acid. Such a detection molecule comprises a) an oligonucleotide, and b) a probe comprising a fi...
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Method and Technology of Production of Echogenic Microbubbles Combining Properties of Drug Carriers and Ultrasound Contrast Agents

In the present invention, echogenic drug-loaded microbubbles are generated from stable micro- or nanoemulsions of perfluorocarbon upon injection into the body. This invention enables users to control the size of the emulsion droplets and bubbles by changing the concentration of a perfluorocarbon and...
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Covalent Tethers for Isolating Homogeneous Proteins

Recent advances in technology have led to methods for generating large sets of genomic and proteomic samples. This has created a need for tools that facilitate rapid screening and analysis of these large sets of samples. Immobilization of proteins and nucleic acids on a solid phase is a useful way...
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Generation of Ribozyme Libraries

Antisense technology provides a platform for drug discovery as well as clinical therapeutic applications. Antisense agents (such as DNA, RNA, and ribozymes) bind to complementary regions on host nucleotides and thereby silence the expression of target genes. Given that target genes and their RNA t...
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Diagnostic Test for Equine Hyperelastosis Cutis

The present invention provides a method of diagnosing equine hyperelastosis cutis (HC), an inherited connective tissue disorder of increasing prevalence in Quarter Horses. The diagnostic test includes determining the ratio of urine deoxypyridinoline (DPD) to pyridinoline (PYD) of a subject horse by...
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Treatment of Mucocillary Clearance in Cystic Fibrosis Patients and Respiratory Inflammation by Using Alkylaryl Polyether Alcohol Polymers

The present invention provides a novel method to use alkylaryl polyether alcohol polymers as antioxidants to block oxidant reactions and prevent tissue injury and disease that are related to overproduction of partially reduced dioxygen (O2) species, such as chronic pulmonary inflammation, myocardial...
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Method of Treating Cancer, Particularly Malignant Melanoma, Using Dithiocarbamate Derivatives

Dithiocarbarmate, particularly tetraethylthiuram disulfide, strongly inhibits the growth of a variety of cancer cells. The present invention provides a novel strategy for treating cancer, particularly metastatic melanoma, by using disulfiram to reduce tumor growth and to potentiate the effect of oth...
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Activating c-kit mutation in melanoma and other cancers - therapeutic and prognostic significance

In cancer treatment, a better understanding of the specific genetic and molecular changes that contribute to tumor growth is leading to the development of targeted therapies, which are predicted to be less toxic and more effective than current treatments. The efficient prescription of these therap...
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Methods for Identifying Chromosomal Aneuploidy

Proper DNA dosage is essential for normal and cellular development and function. Molecular approaches for the detection of chromosomal abnormalities will allow the development of rapid, cost-effective screening strategies. This invention describes a novel, rapid and highly accurate molecular tec...
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Graded Regulation of Protein Activity

Much of biological activity is regulated through posttranslational protein modification in response to various stimuli. Proteins involved in cell proliferation, survival, migration, and shape can be controlled by reversible as well as irreversible modifications (i.e. phosphorylation, acetylation, g...
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Novel Compound to Specifically Stimulate Erythropoietin (EPO) Production for Improved Red Blood Cell Count

This invention discloses an approach whereby the administration of a synthetic organic compound specifically induces proliferation of erythropoietin-producing peritubular interstitial cells in the kidney, which results in increased synthesis of erythropoietin. After cessation of treatment with the ...
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Method of Analyzing Dicarboxylic Acids

This invention describes a method for the high throughput qualitative and quantitative analysis of dicarboxylic acids, and in particular methylmalonic acid (MMA), which exploits the high specificity of tandem mass spectrometry and selective ionization of dicarboxylic acids. Vitamin B12 (cobalamin) ...
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Novel Bioassay and Cell Lines for Direct Bioassay of Androgenic Activity and Steroid Hormone Levels

The present technology provides novel engineered Saccharomyces cerevisiae (yeast) cell lines which are useful in bioassays for the identification and measurement of steroid hormone bioactivity in human serum. The yeast bioassay system has three functional units: a DNA-binding domain, a ligand-bindi...
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Conantokins: peptides with antiseizure and analgesic activity

This invention pertains to conantokins, a subset of peptides isolated from cone snail venom. Conantokins are selective NMDA receptor antagonists that hold promise as antiseizure and analgesic therapies with fewer side effects than currently available treatments. Benefits � Epilepsy, characterize...
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The APC Gene, for Detection and Diagnosis of Inherited and Sporadic Colorectal Cancers

The adenomatous polyposis coli (APC) gene is a tumor suppressor gene which is altered in many colon cancers. Germline mutations of APC are the cause of familial adenomatous polyposis (FAP), an inherited syndrome which leads to the growth of hundreds of colon polyps and a 100% lifetime risk of develo...
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MCC Gene - Mutated in Colorectal Cancer

The MCC gene is in close linkage with the adematotous polyposis coli (APC) gene on chromosome 5q21, a region of frequent loss of heterozygosity in colon cancer. MCC is found to be mutated in some colorectal tumors. Functional studies implicate MCC as a candidate tumor suppressor gene which plays a...
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Suppressing Proliferation of Melanoma Cells by Inhibiting NAD(P)H Oxidase from Producing Reactive Oxygen Species

The present invention provides a method for suppressing malignant melanoma proliferation by inhibiting NAD(P)H oxidase enzymes from generating reactive oxygen species (ROS). Malignant melanoma cells spontaneously generate ROS that promote constitutive activation of the transcription factor nuclear ...
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Methods for Improved Selection of Oligo-Probes for Array Design

Uses of high throughput genomic technologies, including microarray technologies, are growing exponentially. One major limitation of current array technology is the poor predictability of hybridization signal intensity in relation to target concentration. Hybridization signal intensity change in re...
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Therapeutic Target and Screening Method for Inhibitors of Platelet Activation and Coagulation

Platelets are specialized blood cells that function in the formation of blood clots, and these cells act as the key cellular effectors of thrombosis. Tissue Factor (TF) is an essential cofactor for the activation of coagulation and clot formation. This work demonstrates that platelets express TF...
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Molecular Diagnostic Method for Detection of Platelet Activation- Prognostic Significance for Sepsis and Venous Thromboembolism

Platelets are specialized blood cells that function in the formation of blood clots, and these cells act as the key cellular effectors of thrombosis. This work demonstrates that Cdc2-like kinase 1 (Clk1) mediated pre-mRNA splicing is an early control point in platelet activation, and is required ...
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DNA Methylation As a Target for Prognosis and Treatment of Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL), has the greatest prevalence rate among all leukemias. A significant limitation of both the existing staging systems for CLL is that they do not allow for reliable prediction of the rate of disease progression, or which patients are likely to respond to specific tr...
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A Mouse Model of Synovial Sarcoma

The present invention provides the first and only genetic mouse model of synovial sarcoma, a highly aggressive, malignant childhood/young adult soft tissue cancer. This mouse model was generated by conditionally expressing the human SYT-SSX2 fusion protein with myoblasts. It faithfully recapitulate...
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Novel Anti-Reductive Strategies for the Treatment of Heart Failure, Diabetes Mellitus and Degenerative Diseases

Though oxidative stress is widely implicated in pathogenic states including aging and heart failure, the role of reductive stress, which is defined as the abnormal increase of reducing equivalents (e.g., glutathione, NADPH), remains controversial. The present invention provides genetic, molecular, a...
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Predicting Prostate Cancer Resistance to Hormonal Treatment by Measuring Serum Concentrations of Chromogranin A

Continued progression of prostate cancer during endocrine therapy is a major clinical problem. Hormonal treatment resistance and development of metastasis during the treatment have been linked to neuroendocrine cell differentiation within the prostate tumor. Prostatic neuroendocrine cells lack andro...
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Nematode Neuromuscular Junction GABA Receptors and Related Methods

The major inhibitory neurotransmitter in the brain is ?-aminobutyric acid (GABA), which primarily acts through GABAA receptors. Defective GABA neurotransmission causes neurological diseases such as anxiety disorders and epilepsy. GABAA receptor (ca 250 kD) is a ligand-gated chloride channel formed...
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Method for Obtaining an Enriched Population of siRNA-Expressing Cells Useful in Gene Therapy

The invention relates to a method of enriching a population of mammalian cells having an RNA interference (RNAi) sequence by providing eukaryotic (e.g., mammalian) cells containing a target gene. The invention defines a unique plasmid vector able to enrich siRNA-expressing cells to a high level of ...
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Convenient, Accurate Methods of Molecular Haplotyping Using Hybridization Probes and Long-Range PCR

Genetic research has shown that variation or polymorphism in a gene may cause disease, increase risk of disease or affect response to therapeutic treatment of the disease. The particular combination of genetic polymorphisms at multiple loci is referred to as the �haplotype�. If an individual is het...
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Prodrugs and Conjugates of Thiol- and Selenol-Containing Compounds to Treat Cancer and Radiation Exposure

Providing selenium in a nontoxic form is a distinct challenge. Organic forms appear to be superior to inorganic ones. This technology discloses a method for the design, synthesis and evaluation of prodrugs of selenocysteine. The prodrugs of selenocysteine may find wide utility in protection/preve...
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Pestalotiopsis Microspora Isolates and Compounds Derived Therefrom

Endophytic fungi and bacteria are those organisms living within the tissues of host plants. Typically, endophytes coexist with their hosts without any pathogenic symptoms. These organisms have proven to be an unusually rich source of novel bioactive natural products. One of the most ubiquitous endo...
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A Rapid and Sensitive Assay to Measure Hepcidin Levels in Biological Fluids

Hepcidin is a liver-produced peptide hormone which controls iron absorption by regulating the amount of the cell surface iron transporter ferroportin, which exports iron from cells to blood. Altered hepcidin levels are associated with disorders of iron metabolism and absorption, and disease-associa...
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O-glycosylated peptides, including Contulakin G, with therapeutic potential for treatment of pain and seizure

This technology comprises O-glycosylated cyclic peptides, including contulakin- G and derivatives isolated from cone snail venom. These show promise as therapeutics for pain, seizures, and other indications, and have an attractive safety profile. Benefits Potential therapeutic applications inclu...
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Potent Protease-Resistant Inhibitors of HIV Entry, a Novel Compound for Treatment of AIDS

The present invention provides a new family of potent D-peptide inhibitors of HIV entry. These inhibitors have several advantages over Fuzeon, the only FDA-approved HIV entry inhibitor that is currently available. First, these inhibitors are resistant to proteases (potentially allowing oral bioavail...
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Unc-74 Gene Encodes a Novel Transmembrane Thioredoxin Domain Containing Protein, which Is Required for Acetylcholine Receptor Formation

Ligand-gated ion channels are multimeric protein complexes, whose function depends on precise and correct ordered assembly of individual subunits. Using the nematode C. elegans as a model system for acetylcholine (ACh) gated ion channel formation, Dr. Jorgensen and colleague have identified a gene ...
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In-vitro Production of Natural Killer (NK) Cells and Creation of Immortalized NK Cell Lines

Natural Killer (NK) cells provide early defense against pathogens several days before the adaptive immune responses become operational. They are a type of lymphocyte responsible for destroying viruses and tumor cells. An NK cell kills a target cell by releasing perforin (and other molecules) which...
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Designed Antigens to Elicit Neutralizing Antibodies against the HIV-1 gp41 N-Trimer Region to Prevent HIV Entry into the Host Cell

HIV protects its conserved entry machinery with a steric block, preventing the binding of most antibodies. The present invention provides the methods of producing and identifying sterically restricted antigens that mimic this steric block for use as an antigen to select for antibodies that circumve...
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New Model for Nicotinic Acetylcholine Receptors

Signal transduction within and between cells mean that they can communicate important information and act upon it. Aberrant signal transduction is the cause of many of the most personally and financially devastating diseases including cancer, inflammatory diseases, cardiovascular disease and neurop...
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New Methods and Targets for Modulating Odor Sensitivity in Olfactory Epithelium

This invention demonstrates that purine nucleotides and dopamine modulate the odor sensitivity of peripheral olfactory receptor neurons (ORNs). Located in the dorsal recesses of the nasal cavity, these ORNs can be upward or downward modulated in sensitivity, by agonists and antagonists, respectivel...
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Induction of Apoptosis by HIV Viral Protein, a New Target for Treatment of AIDS and Cancer

Since its discovery in the early 1980s, infection with HIV has reached epidemic proportions, especially in developing countries. Estimates suggest that 42 million people are living with HIV/AIDS worldwide, of whom around 3 million die each year. Current treatments involve a cocktail of drugs that ...
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A Rapid Method for in vivo Synthesis of Large Libraries of Cyclic Peptides

Dr. Eric Schmidt and colleagues at the University of Utah have found a novel method to synthesize large libraries of amide-linked, modified cyclic peptides by expression of constructs in Escherichia coli. Benefits *Currently, technology to synthesize amide-linked cyclic peptide libraries is limi...
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Novel Continuous Solvent Extraction Without Moving Parts

Solvent extraction is an efficient method for selectively removing, purifying and concentrating certain elements or compounds from a solution because the solutes can be selectively removed and they can be concentrated from a very dilute stream. Two types of solvent extraction systems are commonly ...
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PCR System for Real-time Quantification of Samples

This invention comprises a nucleic acid quantification kit and method for determining the initial concentration or mass fraction of a target nucleic acid present in a sample. More particularly, the invention relates to the use of real-time competitive quantitative polymerase chain reaction (PCR) an...
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Dual-Sided Microchannel Plate Detector Mount for Coaxial Time-of-Flight Mass Spectrometers

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland Security and the medical community lead the list. Current instruments are either too large to be used as a first responder in the field, too slow in giving results to ana...
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Method for Synthesizing Novel Furanosteroids

The furanosteroids are a class of pentacyclic fungal metabolites that share in common a furan ring bridging positions 4 and 6 of the steroid skeleton. Members of this class are known for their powerful anti-inflammatory and antibiotic properties as well as their ability to selectively block certain ...
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Identification and Uses of Iron and Other Divalent Cations Transporters

Iron deficiency afflicts over 3 billion people worldwide, and plants are the principal source of iron in most diets. In response to iron deficiency, all plants except the grasses induce Fe(III) chelate reductase activity, Fe(II) transport activity and proton release into the rhizosphere. Dartmouth...
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Identification and Uses of a Novel Iron Transporter

Iron is an essential nutrient for all higher plants, with iron-containing compounds figuring prominently in the electron transport systems of photosynthesis and respiration. Although iron is abundant in the soil, the acquisition of iron is problematic due to its low solubility at biological pH unde...
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Identification and Discovery of a New Family of Metal Transport Genes which Can Be Used for Toxic Metals Removal

Pollution of the environment is one of the major problems facing the modern world. Removal of toxic metals poses particularly difficult problems, as unlike organic pollutants they cannot be biodegraded. Currently the standard way of removal of toxic metals from contaminated areas is by excavation ...
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Inexpensive Process for Separation and Mass Production of Cellodextrins

Cellodextrins (-1,4-glucose oligomers) are of interest for investigating cellulase hydrolysis mechanisms and kinetics. In addition, cellodextrins have been used to investigate aspects of microbial cellulose utilization including regulation of cellulase synthesis, cell growth, and bioenergetics. Non...
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Novel Method for Preventing Or Treating Motion Sickness

Motion sickness has been a long-standing problem for travelers, aviators and sailors. For some people, motion sickness symptoms can ruin a trip or even be disabling. Common remedies taken to prevent symptoms often have undesirable side effects. Researchers at Dartmouth have discovered that ...
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Novel Method for Producing Thiono Derivatives Useful in Drug Synthesis

Thionation, the conversion of a carbonyl group to the corresponding thiocarbonyl group, is a standard method for the preparation of a variety of useful organosulfur derivatives, including thionoesters, thionolactones, thioamides, etc. To date, the best reagent for bringing about this transformation...
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Thermostable Purified Endoglucanases from Thermophilic Bacterium Acidothermus Cellulyticius

Technology Description A substantially purified high molecular weight cellulase enzyme having a molecular weight of between about 156,000 to about 203,400 daltons isolated from the bacterium Acidothermus cellulolyticus (ATCC 43068) and a method of producing it are disclosed. The enzyme is water ...
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Targeted Nanoscale System for Combined Therapy and Imaging of Cancer

Background Cancer is the second leading cause of death in the United States. As the number of diagnosed cancer patients increases, there is growing need for improved treatment strategies and imaging techniques for accurate cancer staging and detection. Platform technologies with the ability to both ...
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Surface Functionalization of Polymers for Drug Delivery

Background Currently, wet chemical conjugation and simple adhesion are used to achieve surface functionalization of biodegradable polymer particles. Unfortunately, both of these methods have poor reproducibility, they are inefficient, and they have complex processing requirements and toxicity issues...
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Silver Nanoparticles for Antibacterial and Antiviral Applications

Background The use of antibacterial agents is widespread and can be seen in many products ranging from cosmetics to household cleaners. All tend to rely on alcohol- or triclosan-based ingredients to eliminate pathogens; however, the use of triclosan in antibacterial products has been suspected of ca...
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Rose-Shaped Gold and Iron Oxide Nano Structures and their Applications: Tissue Imaging Contrast Enhancement, Medical Diagnostics, and Photothermal Therapy

Background The identification and treatment of many life-threatening diseases such as cancer, heart disease, and atherosclerosis depends on the outputs provided by innovative medical imaging technologies such as optical coherence tomography, magnetic resonance imaging, photoacoustic imaging, ultraso...
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Molecular Specific Photoacoustic Imaging and Photothermal Therapy

Background Despite enhanced understanding and the development of new therapeutic options, cancer remains a major cause of human morbidity and mortality worldwide. Early diagnosis of malignant events is the single most important factor determining survivability and long-term outcomes. Much effort ...
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Method for Fabricating Arrayed Light Emitting Probes for a Scanning Optical Microscope

The resolution of conventional (far-field) optical microscopes is limited by diffraction to the wavelength of light. The near-field scanning optical microscope (NSOM), a recent advancement, obtains high-resolution images (typically 80-200 nm) by using probe light source, whose size and probe-to-samp...
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Metallic Nanoparticles Directly Functionalized with Protein, Synthesized by Chemical Reduction in Aqueous Solution

Background While there are many ways to synthesize nanoparticles, most have proven hard to solvate. Minor temperature flux can cause nanoparticles to drop out of solution, and current methods yield solutions that last only for a week and must be kept at low temperatures. This makes working with nano...
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Injectable, Disease-Responsive Nanocontainers

Background Current drug delivery technologies rely on diffusion/degradation and are neither targeted nor stimuli-responsive. Further, several MEMS-based drug delivery devices have been formulated, but the efficacy of introducing these drugs to the patient has been compromised. Current technologies r...
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Improved Nanosurgical Efficacy Through Plasmonic Laser Ablation

Background There is widespread optimism that nanosurgery will allow the improved resection of diseased tissues with minimal invasiveness and lessened collateral damage to adjacent healthy tissues. Initial methodologies involve localization of nanoparticles (generally gold nanoshells) to diseased tis...
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Improved Method for Production of Highly Uniform Nanoparticles for Drug Delivery

Background Nanoparticles have multiple applications in tissue targeted drug delivery, non-invasive monitoring of therapeutics, and as delivery devices. They also can be used by the cosmetics, agricultural and pharmaceutical industries to synthesize controlled release particles. Current methods used ...
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Improved Method for Production of Highly Uniform Nanoparticles for Drug Delivery

Background Nanoparticles have multiple applications in tissue targeted drug delivery, non-invasive monitoring of therapeutics, and as delivery devices. They also can be used by the cosmetics, agricultural and pharmaceutical industries to synthesize controlled release particles. Current methods used ...
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Glycerin Based Synthesis of Nanoparticles and Nanowires

Background Currently, there is a rising problem of antibiotic resistance due to certain bacteria exhibiting immunity. Also, there are no completely efficient treatments or vaccines to prevent or treat viral diseases such as HIV, hepatitis C, and human papillomavirus. Invention Description This t...
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Biodegradable MicroSpheres for Drug and Vaccine Delivery

Background Immunizations are an essential tool in the prevention of many infectious diseases. DNA vaccines offer great promise for safer and more effective vaccines when compared to traditional protein immunizations. Current technologies for the delivery of DNA vaccines involve the simple injection ...
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Antiviral Properties of Silver Nanoparticles

Background Current bioconjugates seem to be very unstable in the resulting product, which is a problem in creating a well-rounded nanoparticle. There is currently a need for a better process to inhibit the transmission of the AIDS virus in humans. Current bioconjugate techniques create dense nanopar...
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Prevention of Anthrax Infection with Anthrax Antibody Fragments

Background Current treatments for persons exposed to anthrax spores rely heavily on antibiotics to prevent the growth and ensuing toxicity of the anthrax bacteria; however, these treatments could be compromised through genetic engineering or the natural evolution of anthrax. There is a pressing need...
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Targeted Modification of Genomes with Lactococcus Lactis Ll.LtrB Group II Intron (TARGETRON)

Background Functional genomic disciplines seek to understand the contributions of genes and their protein products in healthy and disease conditions. Due to evolutionary conservation, model organisms provide simplified systems for analysis, while still producing relevant results. Gene function can b...
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Robert M. Krug

Background Current treatments for persons exposed to anthrax spores rely heavily on antibiotics to prevent the growth and ensuing toxicity of the anthrax bacteria; however, these treatments could be compromised through genetic engineering or the natural evolution of anthrax. There is a pressing need...
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Novel Molecular Target for Influenza Virus Antiviral Development

Background Influenza A viruses cause a highly contagious respiratory disease in humans that causes a significant loss of life each year, and dramatic mortality rates during human pandemics. H5N1 avian influenza A viruses, so-called bird flus, which have a human mortality rate of approximately 50% si...
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Methods for the Production of Recombinant Proteins with Multiple Disulfide Bonds in E. Coli

Background Currently, there is no way to produce complex eukaryotic proteins with multiple disulfide bonds in bacteria. This is because the bacteria cannot normally form the correct disulfide bonds in proteins, since they lack the appropriate enzymatic machinery for this purpose. Such proteins must ...
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Method for Pre-Determining and Reversing Toxicity of Drugs

Background Side effects and toxicity are a significant issue with many promising drugs. While a drug may remedy the targeted illness, serious side effects can, in some cases, be worse than the initial malady. In general, the side effects of a given drug are known, but may often be limited to a small...
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Method for biological removal of sulfites from alcoholic beverages and food

Background Sulfite hypersensitivity is an important problem for millions of people. Furthermore, a number of disorders in humans have been proven to be associated with allergic responses to sulfite. Sulfite forms naturally in the body during the oxidative degradation of sulfur-containing amino acids...
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Membrane for the production of oxygen enriched air

Background Many elderly and sick people require oxygen-enriched air to facilitate breathing. Unfortunately, oxygen tanks are heavy and need to be refilled, limiting their convenience. Further, portable oxygen generators/concentrators (which generate oxygen from the surrounding air) are prohibitively...
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Laser Treatment of Cutaneous Vascular Lesions

Background Coagulate vessels often need multiple treatments before they can be destroyed. Current technologies are limited by the finite penetration depth of light and by the natural flow characteristics of blood vessels in tissue. As a result, clinical procedures are often unsuccessful at treating ...
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Influenza Inhibitors

Background The Centers for Disease Control and Prevention estimates that up to 20% of Americans contract influenza each year during flu season. Although most recover, it is estimated that 100,000 of those afflicted, have to be hospitalized, and about 36,000 people die from the virus each year in the...
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G-Quadruplex-Interactive Compounds as Possible Anticancer Agents

Background There have been few dramatic therapeutic breakthroughs in cancer research. Many more anticancer drugs are in use today than ever before, but nearly all of these drugs are severely limited in their use due to the dual problems of drug resistance and lack of selectivity. With cancer becomin...
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Chemical Modification of Polysaccharides for Efficient Delivery of RNA and DNA Therapeutics

Background Nucleic acid-based therapeutics are rapidly becoming the next generation of drugs, offering promising potential for a variety of diseases. Antisense and small interfering RNAs (siRNA) "knock down" (dampen or decrease) the expression of specific, disease-related gene targets and have appli...
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A G-Quadruplex DNA Cleaving Compound and Novel DNA-Cleaving Antitumor Agents

Background There have been few dramatic therapeutic breakthroughs in cancer research. More anticancer drugs are in use today than ever before, but nearly all of these drugs are severely limited in their use, due to the dual problems of drug resistance and lack of selectivity. The guanine-rich ends o...
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Software to Record Auditory Event-Related Potentials

Background Existing software that acquires event-related potentials from human subjects is mostly custom written by the user and not commercially available. Those that are commercially available only operate on specific hardware and only offer a single method for data evaluation. Invention Descr...
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Micro-electro-mechanically Tunable Nano-photonic Grating Displacement Sensor

Background Sensors represent a billion-dollar market characterized by eleven product segments. Two of the sensor product segments are: 1. Proximity and displacement sensors and 2. Force and load sensors. (Global Industry Analysts, 2007) Types of proximity and displacement sensors include: inductive ...
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Methods for Expressing RNP Particles in Eukaryotic Cells

Background Functional genomic disciplines seek to understand the contributions of genes and their protein products in healthy and disease conditions. Due to evolutionary conservation, model organisms provide simplified systems for analysis, while still producing relevant results. Gene function can b...
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Gene Targeting in Eukaryotic Cells by Purified Group II Introns

Background Functional genomic disciplines seek to understand the contributions of genes and their protein products in both healthy and disease conditions. Due to evolutionary conservation, model organisms provide simplified systems for analysis, while still producing relevant results. Gene function ...
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Enhancing the Production of Complex Proteins in Bacteria

Background Numerous therapeutic proteins contain disulfide bonds. However, the production of proteins containing multiple disulfide linkages in genetically engineered bacteria is very inefficient. Bacteria are often not able to produce complex eukaryotic proteins in an active form and in high amount...
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Assays for Identifying Functional Alterations in the p53 Tumor Suppressor

Background The p53 gene is mutated in over half of all tumors, indicating its importance in the process of carcinogenesis. The gene encodes a tumor suppressing transcription factor that binds to certain DNA sequences, thereby activating a number of growth suppressing genes. There is a need to screen...
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Anchored Periplasmic Expression (APEx): a Powerful Technology for Antibody Discovery and Combinatorial Protein Library Screening

Invention Description APEx is a validated method to isolate binding polypeptides, including antibodies or antibody fragments, that recognize specific molecular targets. A library of polypeptide (e.g., antibody) mutants is constructed and expressed in E. coli bacteria. The mutant polypetides are expr...
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A Rapid Colorimetric Assay for Drug Discovery

Background The FDA currently requires pharmaceutical firms to create enantiomerically pure substances, or that the enantiomer of the drug be thoroughly studied and found to have no adverse side effects. The synthesis of enantiomerically pure substances requires the use of reagents that give enantiom...
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A Portable Vector Maximizing Protein Expression in High-Density Bacterial Cultures Using Either Temperature or Chemical Induction

Background Bacterial fermentation remains a popular and reliable form of protein production for both research and commercial applications. Current systems require complementary functional elements present in both engineered bacterial strains and plasmid expression vectors to insure tight control on ...
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Real-Time Imaging and Monitoring of Laser-Tissue Interaction

Background In laser dermatological and oncology treatments, absorbed radiant energy generates an increase in temperature to heat targeted structures. However, before performing laser therapy, it is important to identify the appropriate laser dosimetry required to heat targeted structures and protect...
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Photoacoustic Imaging for Early Detection of Cardiovascular Plaque

Background Almost 81 million individuals in the United States suffer from a form of cardiovascular disease that cost over $400 billion yearly in the United States alone. Coronary heart disease is the number one cause of death in America. Market priorities are to obtain accurate representations of th...
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Improved Nanosurgical Efficacy Through Plasmonic Laser Ablation

Background There is widespread optimism that nanosurgery will allow the improved resection of diseased tissues with minimal invasiveness and lessened collateral damage to adjacent healthy tissues. Initial methodologies involve localization of nanoparticles (generally gold nanoshells) to diseased tis...
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Cell Arrays for Measuring Gene Function on a Genomic Scale

Background Even with the completion of the human genome sequence, the functions and interactions of most encoded genes have yet to be uncovered. Understanding the role of genes and gene networks underlying human development, the onset and progression of disease, and our responses to environmental st...
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A Solid Biodegradable Device for Use in Tissue Repair

Background Conventional methods for tissue repair involve sutures, staples, or clips. By their very nature, they result in a "foreign body" being left in the tissue. Tissue injury and foreign body reaction can give rise to such problems as inflammation, granuloma formation, scarring, and stenosis. I...
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A Miniaturized Optical System for Combined Multiphoton Endoscopy and Ultrashort-Pulse Laser Micro-Nanosurgery

Background According to the American Cancer Society, approximately 2.5 million cases of cancer were diagnosed in the US in 2007 (including basal and squamous cell epithelial cancers), of which 85% originated in the epithelial tissue layer. Diagnosis, early detection, and treatment of diseases at an ...
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Three-Dimensional Fabrication of Bioelectronic Interfaces

Background Bioelectronic interfaces hold great promise for medicine and research; however, current fabrication methods for electronic or electroactive materials typically involve expensive lithographic masks, complicated stamping, and chemical etching. The assemblies produced via this route are inhe...
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Secretion of Folded Recombinant Proteins for Enhancing the Production of Complex Proteins in Bacteria

Background Bacteria are a common source of recombinant proteins for a variety of research, therapeutic, and vaccine applications. Recombinant proteins accumulating intracellularly often form insoluble inclusion bodies. Extraction of properly folded recombinant proteins from inclusion bodies is a com...
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Porous biopolymer hydrogels prepared by in situ crystallization

Background Organ failure and tissue loss account for half the medical spending in the United States. In theory, transplantation is the last therapeutic option available to people in the final stage of an organ or tissue failure. The supply of organs or tissues is so limited that for the vast majorit...
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Patterned Dual Crosslinked Biopolymer Hydrogels

Background Approximately eight million surgical procedures are performed annually in the United States to treat tissue damage resulting from accidents, birth defects, hereditary disorders, and other diseases. Because traditional tissue repair procedures are inefficient, potentially painful to the pa...
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Novel Membrane Materials and Methods for Gas Separation

Background Current methods for CO2 removal are not only very expensive but also cause large losses of gas and the use toxic chemicals. Furthermore, most polymer membranes used for purification are more permeable to small molecules (e.g. H2) than to larger molecules (e.g. CO2). Less permeability then...
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Method for Identifying Novel Telomerase Inhibitors with Utility in Cancer Treatment

Background Certain sequences of DNA are able to form unique, G-quadruplex structures. These structures are implicated in a variety of biological processes. One example of such a process is the cancer-cell specific elongation of chromosome telomeres by the enzyme telomerase. G-quadruplex structures h...
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Improved Production of S-Adenosyl Methionine for Nutraceutical Applications

Background A major drawback to the use of SAM as a medicament is its expense: present methods of production rely on the chemical transformation of methionine, which is an expensive starting material. If a more cost effective method of production were realized, this valuable amino acid could be more ...
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Method for Improved Synthesis of Steroid Hormone Precursors

Background The current method used to convert a,ß unsaturated ketones into a hydroxy ketones or a hydroxy esters results in only moderate selectivity with a low yield. Also, the effectiveness of some contraceptives and hormonal treatments can stand to be improved. Invention Description The proce...
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A Novel Preparation of Pyrroles from Nitriles and Cyclopropanes

Background The new use of known materials to prepare pyrroles in a highly efficient and selective manner is the nature of the discovery. Invention Description A new method for the synthesis of pyrroles from nitriles and cyclopropanes is described. Pyrroles have found applications as pharmaceutic...
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3-Dimensional Bioconstruction Techniques to Connect Electronic and Biological Systems

Background Bioelectronic interfaces hold great promise for medicine and research; however, current fabrication methods of electronic or electroactive materials involve expensive lithographic masks, complicated stamping, and chemical etching. The assemblies produced are inherently 2-D and have not pr...
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System for Site-Specific, Controlled, On-Demand Drug Delivery

Background Current controlled-release drug delivery technologies rely on diffusion/degradation, and are not physiologically responsive. Several MEMS-based drug delivery devices have been formulated, but the efficacy of introducing these drugs to the patient has been compromised. Also, current techno...
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Surface Functionalization of Polymers for Drug Delivery

Background Currently, wet chemical conjugation and simple adhesion are used to achieve surface functionalization of biodegradable polymer particles. Unfortunately, both of these methods have poor reproducibility, they are inefficient, and they have complex processing requirements and toxicity issues...
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Ricin Inhibitors and Methods for Use Thereof

Background Ricin is a potent heterodimeric cytotoxin easily isolated from the seeds of the castor plant, Ricinus communis. The protein consists of a lectin B chain, which can bind cell surfaces and is linked by disulfide bonds to an A chain (RTA), which enzymatically depurinates a key adenine residu...
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Novel Nanoparticles for Drug Delivery

Background Nanoparticles have multiple applications in targeted drug delivery and non-invasive monitoring of therapeutics. The benefits of nano-based drug delivery extend to treatments for infectious diseases as well as cancer, cardiovascular, metabolic, and neurological diseases. Market-driven prio...
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Improved Method for Production of Highly Uniform Nanoparticles for Drug Delivery

Background Nanoparticles have multiple applications in tissue targeted drug delivery, non-invasive monitoring of therapeutics, and as delivery devices. They also can be used by the cosmetics, agricultural and pharmaceutical industries to synthesize controlled release particles. Current methods used ...
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Formation of Stable Submicron Protein Particles by Thin Film Freezing

Background Therapeutic peptides and proteins such as insulin are difficult to deliver through the digestive tract, so they are usually delivered by injection. Inhalation offers a much simpler, painless and effective alternative. Highly porous micron-sized aggregates of protein nanoparticles have the...
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Biodegradable MicroSpheres for Drug and Vaccine Delivery

Background Immunizations are an essential tool in the prevention of many infectious diseases. DNA vaccines offer great promise for safer and more effective vaccines when compared to traditional protein immunizations. Current technologies for the delivery of DNA vaccines involve the simple injection ...
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Very Large Array of Bipolar Electrodes for Sensing of Chemical or Biological Species

Background The development of microarrays is of crucial importance in genomics for genome sequencing or for the determination of gene expression, in proteomics for the identification of pathologic markers, and in biomedical analysis for the realization of point-of-care diagnostics. There is a nee...
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Ultra Compact Fiber-Optic Endoscope for Optical Interrogation of Targeted Depths Within Tissue for the Early Cancer Detection and Surveillance

Background Cancer is the second leading cause of death in the United States; early detection is the key to treatment. In humans, 85% of all cancer originates in the epithelial tissue, including the esophagus, colon, lung, bladder, and cervix. There is currently no way to detect and locate these canc...
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Novel Membrane Receptor for Early Treatment of Breast Cancer

Background An orphan G-protein coupled receptor (GPCR) has previously been shown to be involved in estrogen signaling in breast cancer cells. Also, this GPCR has been suggested to be the membrane estrogen receptor (mER) mediating these estrogen effects. However, no reports were available demonstrati...
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Monolithic Integration of Fresnel Lens with Silicon Microscanner for Endoscopic Imaging

Background The U.S. market for medical imaging equipment increased from $6.7 billion in 2005 to an estimated $7.8 billion in 2007. It should reach $11.6 billion in 2012, a compound annual growth rate (CAGR) of 8.1%. Medical imaging has brought about great improvements in the quality of health care. ...
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Model-based Framework for the Detection of Spiculated Masses on Mammography

Background The detection of lesions on mammography is a repetitive and fatiguing task. Only three or four out of a thousand examined cases are malignant, and thus an abnormality may be overlooked. As a result, radiologists fail to detect 10% to 30% of cancers. Computer-Aided Detection (CADe) syst...
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Method for Ultra-Sensitive Detection of Infectious Agents

Background The sensitive and accurate detection of spores and other infectious agents is essential in clinical environments and biodefense applications. Because of the excellent sensitivities obtained, polymerase chain reaction (PCR) methods are widely used for detection purposes. However, many diff...
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Laboratory Assay for Early Diagnosis of Alzheimer's DiseaseBackground

Background Current Alzheimer's disease (AD) diagnostic tools which utilize biological markers have low rates of success or involve invasive techniques that are at best uncomfortable and unreliable. Other tools incorporate bulky and expensive machinery. Moreover, many of the latter tests rely on the ...
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Hand-Held Silicon Scanner Enabled Single-Fiber Confocal Microscopy for Cancer Detection

Background The American Cancer Society shows 15 million people were diagnosed with oral cancer in 2004. Cancer cure and survival rates are tied directly to the stage of the cancer at the time of diagnosis. Early detection in many cases can permit minimally invasive treatment and greatly improves lon...
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Monoclonal Antibody 3D8 - a CD 13 Antibody ( 89008)

A murine monoclonal antibody (mAb) directed against the human CD13 antigen has been developed at Northwestern University. MAb 3D8 appears to be myeloid restricted, reacting with myeloid cell lines, peripheral blood monocytes, and macrophages of the reticuloendothelial system and lung. However, this ...
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Transgenic Mice Expressing Superoxide Dismutase ( 94011)

Researchers at Northwestern University have created a unique transgenic mouse model that expressed superoxide dismutase (SOD). This is an excellent animal model for the analysis of Cu- or Zn-superoxide dismutase in amyotrophic lateral sclerosis (ALS), also called Lou Gehrig's disease, which is a pro...
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Heat Shock Factors HSF1 & HSF2 Rat Monoclonal Antibodies ( 96097)

This invention describes antibodies directed against heat shock factors, HSF1 and HSF2. HSFs (also designated heat shock transcription factors) are involved in the transcriptional regulation of heat shock proteins (HSPs) which are rapidly induced in organisms in response to various environmental and...
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KPL1, a Monoclonal Antibody (mAb) Directed Against a Leukocyte Glycoprotein Named P-selectin Glycoprotein Ligand-1 (PSGL-1) ( 97026)

This invention describes a novel mAb, KPL1, that completely blocks the interaction of PSGL-1 with either L-selectin or P-selectin leukocyte adhesion molecules. KPL-1 is therefore useful in studying interactions between leukocytes and either platelets, endothelium or other leukocytes. KPL-1 has prove...
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A Function Blocking Monoclonal Antibody Against alpha4 Laminin ( 99053CIP

Recently researchers at Northwestern University have developed a function blocking monoclonal antibody (mAb) to the a4 subunit of laminins. This antibody, mAb 2A3, inhibits angiogenesis and endothelialization in vitro and in vivo. SCIENTIFIC BACKGROUND: Integrins are cellular receptors that medi...
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Analysis of Muscular Activity in Neonatal Animals to Screen for Mutations and/or Drugs that Alter Sleep and Wake States ( 99072)

Northwestern investigators have developed a high-throughput screening method for novel genes and/or drug compounds associated with the sleep and wake state. Previously it has not been possible to screen a large number of sleep-related drugs and/or genes in rodents because of the time, cost and invas...
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Surface-Associated Delivery of Genes and Oligonucleotides for High Throughput Functionality Analysis (20071ht)

Investigators at Northwestern University have invented a novel system appropriate for the high-throughput analysis of gene function and an approach for the controlled, efficient delivery of DNA or oligonucleotide (ON) complexes from a surface, from which multiple genes or ONs can be delivered in par...
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A Protocol to Experimentally Identify Non-specific, Non Drug-Like Ligand “Hits” from Drug Discovery Screening Assays (20096)

To discover new lead compounds for drug design, large libraries of chemical compounds are screened for their ability to modulate receptor and enzyme protein activity and function. The screens for such compounds are performed experimentally (high throughput screening) or computationally (virtual scre...
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A Protocol to Experimentally Identify Non-specific, Non Drug-Like Ligand “Hits” from Drug Discovery Screening Assays (20096)

To discover new lead compounds for drug design, large libraries of chemical compounds are screened for their ability to modulate receptor and enzyme protein activity and function. The screens for such compounds are performed experimentally (high throughput screening) or computationally (virtual scre...
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Tau-13 Monoclonal Antibody (20081)

Tau-13 is a mouse monoclonal antibody (mAb) that binds to human tau as demonstrated by ELISA and immunoblot assays and is able to stain brain tissue early in Alzheimer’s disease. The Tau-13 mAb would be useful to researchers who wish to detect human tau in solid phase assays as it has a remarkably h...
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Monoclonal Antibodies for Laminin-5 and Hemidesmosomes (21015)

This invention describes a number of monoclonal antibodies (Mabs) specific to the different subunits of laminin-5 and hemidesmosomes (HDs). These monoclonal antibodies may be used to study epithelial cell motility, cell proliferation, cytoskeleton formation, cell adhesion, and the process of wound h...
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OSR-1 Nucleic Acids and Proteins (22064)

Investigators at Northwestern University have identified several novel genes that effect dehydration resistance in nematodes: when expression of these genes is modulated, parasitic and beneficial nematodes have altered sensitivity to dry, high salinity environments. In particular, knocking out these...
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Dual Function Lipid-Based Transfection Agents: Combination of Drug and DNA Produces Large Increase in Efficiency (22094)

INVENTION: Novel liposomes have been developed that are useful as non-viral vectors to deliver DNA to cells. The invention described herein focuses on the use of lipoplexes with incorporated microtubule disrupting agents as non-viral gene delivery vectors that can efficiently and non-toxically deliv...
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G Protein Mediated Function as a Target for Malaria Chemotherapy (22096)

Investigators at Northwestern University have identified that beta-blocker drugs are effective inhibitors of malarial infection in vitro and in vivo. Beta blockers are inexpensive, approved to treat cardiac indications, non-toxic, and otherwise well-tolerated in patients. Research and development e...
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Improved Transfection Efficiency Using Combination Lipoids (22112)

Robert C. MacDonald et al., developed novel liposomes useful as transfection agents to deliver nucleic acids to cells for which efficient transfection with conventional agents is difficult. The novel transfection agent, MLS, is a mixture of two cationic components (L and S) that are combined in diff...
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Zinc-Chelating Ratiometric Fluorescent Probes and Related Methods

INVENTION: Investigators at Northwestern University have synthesized a new class of zinc-chelating probes that are useful as ratiometric probes for zinc (Zn(II)). The development of this probe allows the use of a new research reagent to be utilized in the investigation of the functions of zinc in bi...
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Tau C3 Monoclonal Antibody (23065)

Recently, a new antibody specific for caspase cleaved Tau was developed at Northwestern University. This antibody Tau C3, is a mouse monoclonal antibody (mAb) that binds to human tau truncated at aspartic acid 421 as demonstrated by ELISA and immunoblot assays. The antibody stains amyloid beta treat...
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A Novel Thermo-Gelling Matrix for Microchannel DNA Sequencing (23110

Northwestern investigators have created novel "thermo-gelling" polymer networks for use as DNA sequencing matrices for high-throughput microchannel electrophoresis in capillary arrays. Capillary array electrophoresis with these networks provides efficient resolution of both small and large DNA seque...
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Tau-12: Monoclonal Antibody Specific for the N-terminus of Tau (25105)

A mouse monoclonal antibody specific for residues 9-18 in the amino terminus of tau. The antibody is of the IgG1 isotype and is phosphorylation independent. This epitope is lost after cleavage at Asp13 by caspase-6. SIGNIFICANCE: Previous work has shown that loss of Tau-12 immunoreactivity in t...
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A Rabbit Animal Model for Uterine Fibroid Embolization (26021)

Although uterine artery embolization (UAE) is widely used clinically, an animal model containing actual uterine fibroids does not exist. Development of such an animal model would be desirable as a platform for interventional radiologists to a) test embolic therapies; b) determine the most appropriat...
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Tau-nY29: Monoclonal Antibody Specific for Tau Nitrated At Tyrosine 29 (27006

A mouse monoclonal antibody (IgG1) to detect nitration in a protein-specific and site-selective manner. This antibody recognizes tau only when nitrated on residue Tyr29. It does not cross react with wild type tau, tau mutants singly nitrated on Tyr18, Tyr197, and Tyr394, or other proteins known to ...
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Self-Assembling Membranes and Related Methods Thereof (27009)

A self-assembling liquid polymeric system for the synthesis of robust sacs and string membrane structures having properties suitable for cell and therapeutic delivery, diagnostic and tissue repair applications. ADVANTAGES: Facile generation of biocompatible membrane structures with excellent mech...
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Immortalized Retinal Müller Cell Line rMC-1

INVENTION: Müller cells are the most abundant non-neuronal cells in the vertebrate retina. It is known that they perform a variety of functions that support the activities of retinal neurons, but there has been little progress in elucidating the mechanisms underlying these functions. Primary culture...
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Prestin, the Motor Protein of Cochlear Outer Hair Cells, and its Gene, Pres

INVENTION: Researchers at Northwestern University have isolated a novel molecular motor molecule, Prestin, from outer hair cells (OHCs) of the mammalian cochlea. This unique biological motor is capable of direct, rapid, electro-mechanical conversion without dependence on ATP. The ability of this mol...
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INVENTION: the “BioChip” invention electronically detects biomolecules and toxic agents. When a target species chemically binds to the surface of a tiny cantilever probe, the probe deflects and the Bi

INVENTION: The “BioChip” invention electronically detects biomolecules and toxic agents. When a target species chemically binds to the surface of a tiny cantilever probe, the probe deflects and the BioChip electronically measures and reports that deflection. The BioChip presents the following advant...
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Micro/Nano-Fabricated Glucose Sensors

INVENTION: This invention is a novel glucose sensor that uses the hydrogen-specific gas sensing capability of single walled carbon nanotubes (SWCNT’s) assembled on a microelectrode. The conductivity of SWCNT’s changes due to adsorption of hydrogen that causes the energy band structure of SWCNT’s to ...
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New Silver Containing Cathode for Primary Lithium Batteries for Medical Devices

INVENTION: Northwestern researchers have synthesized a new cathode, Ag4V2O6F2, (SVOF) with significantly higher accessible silver content than current medical battery cathodes employing silver vanadium oxide (SVO). Greater capacity and potential are produced compared to SVO. In addition the chemical...
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Rapid Detection of an Anthrax Biomarker by Surface-Enhanced Raman Spectroscopy

INVENTION: Northwestern researchers have created a surface-enhanced Raman biosensor for use in detecting and identifying Bacillus anthracis, a spore-forming bacterium and dangerous pathogen for the disease anthrax. The system promises the potential for detecting other hazardous microorganisms. AD...
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Microchannel Assemblies as Artificial Blood-Capillary Beds for Artificial Organs

INVENTION: A thin biocompatible wafer with millions of micron-size channels has been designed to allow for efficient transport in artificial organs. This wafer may be significantly important in artificial lung design. BACKGROUND: A major function of most internal organs (e.g., lungs, kidneys, liv...
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Surface Enhanced Raman Nanobiosensor

INVENTION: Scientists at Northwestern have created surface-enhanced Raman biosensors for detection of in vivo and ex vivo analytes. In particular, the present invention provides a technology for the in vivo detection of blood glucose.>/p> ADVANTAGES: A potentially faster, easier, and less painfu...
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Method of Making Silver Vanadium Oxide Material Useful as a Battery Cathode

INVENTION: Ag2V4O11 (SVO) and Ag4V2O6F2, (SVOF) are important cathode materials for medical battery applications such as defibrillators. A one-step process has been developed affording crystalline SVO and SVOF by reaction under ambient conditions, eliminating the need for superambient pressure and t...
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SMOFC Battery Cathode

INVENTION: A novel battery cathode composition having a higher discharge capacity available from silver reduction at a potential above 3V compared to that of the current standard medical battery cathode SVO material. ADVANTAGES: Batteries incorporating the new cathode exhibit a potential above 3...
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Surface-Immobilized Antimicrobial Peptoids

INVENTION: Northwestern researchers have developed peptoid mimics of antimicrobial peptides that can be immobilized onto surfaces, rendering these surfaces capable of compromising the membranes of attached bacteria. ADVANTAGES: Peptoids afford promising alternatives to conventional antimicrobial...
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Method for Identifying Drug Targets in Biological Networks

This is the extension of the bridging centrality network to biological networks. In the network representation, proteins and other biological molecules are the nodes of a network and the interactions between the molecules are the edges connecting nod es. The degree of a node and and centrality have ...
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High-Throughput Synthetic Platform for Natural Product Analog Libraries

Summary Background: In small molecule drug development, researchers typically develop biased libraries in which all members share a particular characteristic, such as an ability to interact with a particular target ligand or structural features designed to mimic a particular aspect of a class of nat...
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Novel Peptide Therapeutic for Multiple Sclerosis

Summary Background: In Multiple Sclerosis, the host’s immune system (lead by T cells) attacks and destroys myelin basic protein, the principle component necessary for nerve transmission. Part and parcel of this immune response pathway are the so-called Major Histocompatibility Complex (MHC) molecu...
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Application of streptococcus intermedius intermedilysin (ILY) for obesity treatment and contraception

Summary A bacterial toxin has been shown to enhance immune reactions to adipocytes when injected locally, facilitating antibody-mediated and complement-dependant cytolysis. Applications A peptide therapeutic for localized delivery for the ablation of fat cells. Results from localized injection si...
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SMERs: Small Molecule Enhancers for Treatment of Cancer and Neurodegenerative Diseases

Summary Background: Autophagy is the process by which cells cannibalize cellular elements such as proteins and organelles to generate intracellular metabolites for cell survival and cell death. For example, a cell undergoes autophagy for architectural remodeling during development or to eliminate da...
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Inhibition of Sirt$ for treatment of obesity and ehancing fat metabolism

Summary A method of screening for compounds that modulate SIRT4 fatty acid oxidation activity. SIRT4 is a mitochondrial protein that plays a central role in regulating amino acid stimulated insulin secretion (AASIS) in pancreatic ?-cells by inhibiting glutamate dehydrogenase and impacting fatty a...
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Inhibitors of Cellular Necrosis

Summary A new paradigm in cell death has been discovered, Necroptosis. Necroptosis reflects a distinct mechanistic pattern of programmed cell death that combines elements of passive unregulated necrosis and organized, energy-dependent apoptosis. Activated by the TNF family, sterols, and toll-like re...
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ras Oncogene Inhibitors

Summary Activated ras genes have been associated with a number of human cancers. An activated ras gene, H-ras-1, was the first non-viral oncogene discovered. Several other human ras proto-onco genes have subsequently been identified including H-ras-2, K-ras-1, K-ras-2, and N-ras. Activated K-ras gen...
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Hyperactive mutant of the Himar1 mariner transposase

Summary Mariner-family transposable elements are active in a wide variety of organisms and so are important genetic engineering tools. The Himar1 element, isolated from the horn fly, Haematobia irritans, has been shown to be active in E. coli. Hyperactive variants of the corresponding transposase ha...
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"Teabag" Processing: an Automated, High Throughput Method for Affinity Purification

Summary A high throughput system for protein purification has been developed, whereby a “tea-bag” structure is used to house microspheres for targeted protein binding and elution. The microspheres are compatible with any solid-phase protein purification, which includes coupling of Ni++/Histidine...
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Programmable Generation and Transport of Droplets on Microscale Surface Texture Ratchets

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications. Currently, many laboratory processes can be combined on a single chip commonly only millimeters in size while manipulating liquid volumes of picoliter size or less. In order to effectively...
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An optical spectroscopic approach for quantifying Hb/Mb ratio noninvasively noninvasively

Introduction Impaired blood flow and mitochondrial defects are involved in a wide variety of metabolic and degenerative diseases. The inability to quantify tissue hemoglobin (Hb) content presents a significant barrier to non-invasive assessment of regional mitochondrial function in blood flow. Techn...
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Biomarkers for Cardiovascular Disease

Introduction Cardiovascular disease (CVD) is the leading cause of death among both men and women in the United States and, as such, is associated with high costs in terms of health care, morbidity, and mortality. An important aspect of the fight to reduce CVD is the development of diagnostic tests t...
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Oxidation Resistant form of Apolipoprotein A-I

Introduction High density lipoprotein (HDL) protects against atherosclerosis by removing cholesterol from cells of the artery wall. Apolipoprotein A-I (apoA-I), which accounts for ~70% of the total protein in HDL, promotes cholesterol and phospholipid efflux largely by an active transport process. T...
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Fabrication of Gold Nanocages and Cubic Nanoframes for Biomedical Treatment through Etching Nanoboxes

Introduction Because of their small sizes and unique properties, nanomaterials are finding widespread use in studying complex biological systems. Gold nanostructures have been the subject of intensive research because of their unique and tunable surface plasmon resonance (SPR) properties. Because of...
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Automated Yeast Pedigree Analysis

Introduction Saccharomyces cerevisiae, or budding yeast, is a single-cell eukaryotic microorganism that commonly is used by biologists to study genetics. Yeast pedigree analysis is used to study genomic instability associated with aging and cancer and involves the isolation and characterization of t...
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The Multiple Drug Resistance Gene, Polymorphisms, and uses Thereof

Introduction Multiple drug resistance is a well-documented phenomenon and critical problem in the treatment of various diseases including cancer and HIV. While there are many mechanisms leading to multiple drug resistance, one area of focus is the MDR1 gene and its protein product P-glycoprotein (Pg...
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Localization Wire for Surgical Excision of Breast Lesions

Introduction With the introduction of screening mammography, the median tumor size has decreased considerably, and approximately half of breast cancers in surgical practice are non palpable and amenable to breast conserving surgery. Traditionally, non palpable lesions are excised with a wire or wire...
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Surface Receptor Antigen Vaccines

Introduction The invention relates to DNA vaccines, or vaccines containing molecules encoded by such DNA, for the induction of specific, sustained high titer antibody responses. More specifically, the invention is directed to DNA vaccines that comprise recombinant expression constructs encoding a ce...
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Improved use of Recombinant Viruses for Liver Regeneration

Introduction Diseases of the liver, both genetic and acquired, are especially detrimental due to the fact that the liver is a key organ for most metabolic pathways. Currently, the only method of curing liver diseases is via a liver transplant. Unfortunately, many transplants succumb to rejection, le...
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Novel Thymidylate Synthase Mutants for Treating Chemotherapy-induced Mucositis and Other Chemotherapy Side Effects

Introduction 35 novel thymidylate synthase (TS) mutants have been generated by random mutagenesis. These mutants are different from wild type TS in single, double, or multiple mutations, which are located distant from the active center. The new TS mutants reveal enhanced resistance to TS-inhibiting ...
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Porphyromonas gingivalis LPS as an Immune Modulator

Introduction Vaccines often require the use of adjuvants, immune modulating substances, to generate adequate immune responses for the prevention or treatment of disease. Current adjuvant systems often display toxic properties, can be unstable, and can have unacceptably low immunostimulatory effects....
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Diagnosis and Treatment of Malignancy

Introduction Novel methods for the detection, monitoring, treatment, and prevention of malignancies have been developed that are based on the body’s own immune response to cell surface markers on cancer cells. Technology description Detection of the proliferation of T-cells in response to in vitro e...
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Compositions and Methods for Detecting Pancreatic Cancer

Introduction Pancreatic cancer is a highly lethal disease; it is highly invasive and unresponsive to standard chemotherapy. The discovery of genes that cause familial forms of cancers has often shed light on the biology of the sporadic form of the disease. University of Washington researchers have i...
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Molecules and Methods for the Treatment and Detection of Cancer

Introduction Approximately 30,000 women are diagnosed with ovarian cancer yearly in the United States, and only about 50% of those diagnosed will survive the disease. Early, accurate prognosis of ovarian cancer is closely related to stage of the disease at diagnosis. It is estimated that about 106,0...
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Mouse Model of Gastrointestinal Stromal Tumor (GIST)

Introduction Recent developments have firmly established the important role of receptor tyrosine kinases in human cancer. Kit is a receptor tyrosine kinase and its role as a cellular oncogene has been established in a number of cancers including gastrointestinal stromal tumors (GISTs), which belong ...
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Construction and Use of Mutant Herpes Thymidine Kinase Genes in Cancer Therapy

Introduction In addition to surgery, many cancers are also treated with a combination of therapies involving cytotoxic chemotherapeutic drugs and/or radiation therapy. However, disadvantages to this method are that radiotherapeutic and chemotherapeutic agents are toxic to normal tissues, often have ...
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Methods and Compositions to Quantitate Thyroglobulin in Human Blood Specimens

Introduction Thyroglobulin is a marker of thyroid cancer. The presence of thyroglobulin in the plasma/serum of patients indicates functioning thyroid tissue. Following surgery and treatment with radioactive iodine, patients with thyroid cancer should be free of all functioning thyroid tissue. Detect...
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Grasper Pad Sensing

Introduction Minimally invasive surgery is now being used routinely as one of the most preferred choices for various types of operations. Despite its many advantages, such as reduction of trauma, less pain, smaller injuries, faster recovery time, and reduction of postoperation complications, MIS dec...
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Transgenic Mice Expressing Human Myeloperoxidase

Introduction Myeloperoxidase (MPO) co-localizes with macrophages in the human artery wall, and its characteristic oxidation products have been detected in atherosclerotic lesions. Thus, oxidants produced by the enzyme might promote atherosclerosis. However, macrophages in mouse atherosclerotic tissu...
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A Microfluidic Device and Methodology for Rapid, Quantitative Determination of Analyte Concentration in a Fluid Sample

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, especially for biosensors and environmental monitoring. One recent area of interest is point-of-care diagnostic devices. These devices provide fast, accurate, and inexpensive sample analys...
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A Novel Diagnostic Test for Atherosclerosis and Clinically Active Coronary Artery Disease

Introduction Low levels of high density lipoprotein (HDL) are associated with a greatly increased risk of coronary artery disease (CAD). Evidence indicates that HDL protects against atherosclerosis by removing cholesterol from macrophages in the artery wall. In vitro studies indicate that chlorinati...
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Warfarin Dosing and Genetic Variation

Introduction Warfarin is an anticoagulant used to prevent the blood from forming dangerous clots that could result in stroke. Determining the most effective and safest dose for each patient is extremely complicated and time consuming as warfarin metabolism varies greatly between patients and is affe...
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Phospholipid Transfer Protein, a Regulator of Cholesterol

Introduction The level of cholesterol in the blood is an important risk factor for atherosclerosis and coronary artery disease (CAD) which can eventually lead to heart attack or stroke. Cholesterol is present in many forms, the most familiar of which are the lipoproteins LDL and HDL. As atherosclero...
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Targeting Drugs to the Lymph Nodes for HIV and Cancer Therapies

Introduction HIV patients are currently treated using “HAART,” a highly active anti-retroviral therapy in which a plethora of drugs are administered to patients. This therapy is effective in reducing virus concentration in the blood, however, studies have shown that levels in the lymph nodes do not ...
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Methods of treating pulmonary disease using acetazolamide and structurally related derivatives

Introduction Alveolar hypoxia, as occurs with chronic lung diseases or ascent to high altitude, results in hypoxic pulmonary vasoconstriction (HPV). Exaggerated HPV causes high altitude pulmonary edema (HAPE) and may complicate the course of patients with chronic cardiopulmonary disease. HPV is bel...
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Treatment of Microvascular Angiopathies

Introduction Acute injuries to smaller blood vessels and subsequent dysfunction of the tissue in which the injured blood vessels are located (microvascular angiopathies) are common features of a variety of diseases of different organs, such as kidney, heart and lungs. A subgroup of such diseases is ...
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Non-toxic protocol to establish paraoxonase 1 (PON1) status

Introduction Paraoxonase 1 (PON1) is a member of a three-gene family localized on human chromosome 7. Due to its role in the metabolism of both lipids and organophosphorus (OP) compounds, genetic variability in PON1 has been examined by many research groups as a risk factor for vascular and other d...
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Platelet Clotting Force Array

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, such as point-of-care diagnostic devices. These microscale diagnostic platforms will enable faster, cheaper, and more accurate patient evaluation for a wide array of parameters. One such p...
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BCRP expressing cell lines

Introduction The breast cancer resistance protein (BCRP) is an ATP-binding cassette efflux transporter originally identified by its ability to confer multidrug resistance in cancer cells. BCRP mediates the efflux transport of a broad spectrum of substrates, including many drugs routinely administere...
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A Mouse Model for Osteoporosis

Introduction Osteoporosis, an age-related disease in which loss of bone mass causes skeletal deformities and fractures, affects nearly 20 million people in the US, mostly women. A major complication is a fracture of the thigh bone, in which case 20-30% of patients die in the year following the fract...
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Type III Adenylyl Cyclase Gene Knockout Mice

Introduction The olfactory sensory system has the remarkable capacity to detect and discriminate among a wide array of odorants and translate them into cognitive representations. Cyclic nucleotide–gated ion channels in olfactory sensory neurons (OSNs) are hypothesized to play a critical role in olfa...
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Zinc Transporter-3 Knockout Mouse

Introduction The presence of histochemically reactive zinc within synaptic vesicles defines a subset of neurons that have been termed zinc-enriched (ZEN) neurons. Because ZEN neurons are prevalent throughout the limbic system and zinc is capable at physiological concentrations of exerting neuromodul...
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Diabetes Food Additive, Neutraceutical & Drug

Project 1: We currently are marketing / outlicensing a diabetic food additive / neutraceutical. Possible Drug development aspects. Project 2: We are looking for a grant, an angel investor(s) and/or venture capital group to bring to NCE status a new drug to treat and prevent Alzheimers. If you ...
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Neuroprotective Agent for the Treatment of Ischemic Stroke

Novel neuroprotective peptide agent capable of reducing the amount of ischemic brain injury. Description Researchers at the Centre for Addiction and Mental Health have developed a novel neuroprotective peptide agent capable of reducing the amount of ischemic brain injury. This is accomplished b...
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University of Nebraska-Lincoln Technology Out-Licensing Opportunities

The Lincoln, Nebraska-based Office of Technology Development (OTD): http://otd.unl.edu/ manages the intellectual property assets of the University of Nebraska-Lincoln. OTD’s mission is to help turn academic research into tangible products and services, while returning income to the inventors and to ...
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NH-7211 – a Broad Acting Anti-Alzheimer’s Compound

Novel small chemical compounds capable of disrupting the three key misfolded proteins responsible for Alzheimer’s disease (AD) and other CNS disorders Description Our researchers have created novel small chemical compounds capable of disrupting the three key misfolded proteins responsible for A...
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Epilepsy, Alzheimers & Parkinson's Drug Development

Upsher-Smith Laboratories, Inc., is a privately held, specialty pharmaceutical company with headquarters in Minneapolis, MN (www.upsher-smith.com). The company is seeking collaborative partners and out-licensing opportunities for improved drug therapies that treat epilepsy, Parkinson's and Alzheimer...
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Drug Delivery Technologies

Upsher-Smith Laboratories, Inc., a privately held, specialty pharmaceutical company with headquarters in Minneapolis, MN (www.upsher-smith.com), is actively seeking Canadian companies or research organizations with technology or expertise in various areas of drug delivery. Background Upsher-...
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Women's Healthcare

Upsher-Smith Laboratories, Inc., a privately held specialty pharmaceutical company with headquarters in Minneapolis, MN (www.upsher-smith.com), would like to augment its current portfolio with marketed or near-to-market women’s health products. Upsher-Smith Laboratories, Inc., a privately held spec...
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Spinal Disc Nucleus Replacement

BACKGROUND In the last 10 years commercial interest in treatment of spinal degeneration in relation to back pain has increased with a large number of devices competing in a market estimated to be worth more than $3.5bn and growing at 15 - 20% pa. This technology being developed at the University of ...
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eLUNSERS: a SOFTWARE TOOL FOR MONITORING THE SIDE-EFFECTS OF NEUROLEPTIC DRUGS

BACKGROUND Neuroleptics are the drugs of choice in the treatment of schizophrenia, bipolar mania and related disorders but suffer from troublesome side-effects such as drug induced parkinsonism, restlessness, facial tics etc. The severity and patient acceptability of these effects varies widely. Res...
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Collaboration/Licence Opportunity Size and Permeability Selective Encapsulation and Delivery of

BACKGROUND Although there is considerable research being carried out in the area of hollow sub-micron constructs for the purposes of encapsulation of useful therapeutic entities, most of the processes developed to date for the preparation of such constructs are incompatible with maintaining the func...
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Novel Anti-helminthic

BACKGROUND Gastrointestinal nematode infections are amongst the commonest infections of man and animals worldwide. Collectively 1 in 3 people on the planet are infected by at least one species and approximately 50% of these are school age children In the developing world they affect the well being o...
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Novel Antimicrobial Peptides

BACKGROUND Ai2 Limited is a University of Manchester spinout company that aims to become a significant player in the global anti-infectives market. The company’s focus is on developing novel anti-microbial products, for out-licensing to healthcare companies across a range of sectors. THE TECHNOLOGY ...
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3-D Self-assembled Peptide Hydrogels

BACKGROUND Pre-designed self-assembling scaffolds are highly advantageous in a number of areas, including tissue regeneration, 3D cell culture, in vitro toxicity testing and understanding of cell/extracellular matrix interactions. Self-assembling peptides, with the various properties of amino acids ...
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Biodrug Delivery Mechanism Via Yeast Encapsulation

BACKGROUND A research project in in the Faculty of Life Sciences at the University of Manchester has led to the development of a novel yeast-based drug delivery mechanism. THE TECHNOLOGY A genetically engineered yeast strain, able to express recombinant protein drugs / vaccines and incorporating a g...
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mapping and quantifying the contribution of elements to the overall performance of the system they compose

BACKGROUND Research at the University of Manchester has identified a new tissue marker with potential use in the stratification of breast cancer patient groups and improved targeting of treatment for each patient. THE TECHNOLOGY The human homolog of the suppressor of deltex protein (SDRP) is aberran...
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Multi-Silencing Algorithm (MSA) for analysis of ´Multi-Knockout´ and perturbation experiments

The Invention The invention describes a new, reliable and efficient method for mapping and quantifying the contribution of elements to the overall performance of the system they compose. The Need With the genomic revolution a huge amount of data has become available concerning the expression of...
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Detoxification of Tannins in Transgenic Plants

A novel genetic system for the elimination of tannins in edible plant materials such as canola seeds and sorghum seeds has been developed. This involves genetic engineering of these plants such that they accumulate a tannin-detoxifying agent. The Need Global agricultural production is greatly infl...
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Inhibitors of Systemic Virus Spread in Plants

The Invention Plant viruses and viroids exploit plasmodesmata nano-channels as conduits for viral spread. Plasmodesmal proteins, endogenous to plants, have been modified such that they permanently block plasmodesmata nano-channels. This blockage inhibits plant virus spread: a major cause of reduced...
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Domestication of the Marine Nudibranch Spurilla Neapolitana for Commercial Husbandry: Targeting the Marine Ornamental Industry

The Invention A technology was developed enabling the domestication / commercial husbandry of S neapolitana - The optimal pest control for marine aquaria.The novel technology includes special culture media for propagating the distinct nudibranch life cycle stages, and unique culture apparatus for p...
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Medical Spectroscopy

DOMAIN Aging of injuries on a victim’s body is an important aspect of forensic medicine. Currently, visual assessment and colorimetry based on empirical criteria are the most common techniques for this task, although the results are uncertain. The aim of this study was to develop a mathematical mode...
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Diagnosis and prognosis of cancers in GI tract

DOMAIN Although the incidence of gastric carcinoma (tumour in stomach) is declining, this disease is still the second most frequent cause of cancer death worldwide. Gastric carcinomas are often not detected until at an advanced stage; consequently, the 5-year survival rates are low and most often in...
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Alginate - Drug Delivery System

DOMAIN The mucosal surfaces of the body (such as GI tract, respiratory tract, eye, and genitourinary tract) constitute the major target for drug and gene delivery. As such, mucous secretions can have a significant influence on drug/gene complex uptake. These effects of mucus are usually more pronoun...
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Rapid prediction of gene expression levels using spectroscopy

DOMAIN The study of gene expression in cells is increasingly being used to understand their biological function. The genes are up- and down-regulated by a complex protein regulatory network, which responds to the biochemical changes originating from within and outside the cell. One of the most popul...
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Optimal selection of flurophores for bioimaging using hyperspectral cameras

DOMAIN In many situations it would be beneficial to have an instrument that can show In biology and medicine, fluorescent labelling is used to detect the location and concentration of various molecules. This can be used to discover how molecules are interacting in relation to diseases and biological...
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Real time hyperspectral imaging

In many situations it would be beneficial to have an instrument that can show directly the spatial distribution of various chemical components in real time of a surface. Typical application areas are forensic and military where investigators can rapidly locate the presence of blood, gunpowder, toxic...
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ThirdEye – early detection of cerebral palsy (CP)

DOMAIN An early and accurate detection of cerebral palsy (CP) enables correct treatment at an early age to the infant at risk. Today’s methods for detecting CP are unable to establish a diagnosis until late in the first year of life, in some cases even later. Experts are currently doing analysis of ...
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MEMRI (manganese enhanced MRI)

DOMAIN Within an ageing population, ischemic heart disease (IHD) and secondary heart failure represent major challenges underlining a demand for diagnostic imaging to identify IHD in its different stages and forms. There is also a need to diagnose heart failure developing after myocardial infarction...
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Determining leakage through a heart valve

Determining the severity of a leakage through a heart valve is important. There are several parameters that are clinically interesting in this regard: the area of the lesion, the flow or flow rate through the lesion and the geometry of the lesion. These three parameters are not easy to measure. Curr...
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Glycosylase enzymes

DOMAIN Glycosylases have found use in a number of methods aimed at analyzing DNA for the presence of altered nucleobases that could result from ionizing radiation or chemical oxidants, identifying mismatched base pairs, studying repair of abasic sites in double-stranded DNA and as a means to prevent...
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