A Method of Transfection and Compositions Therefor
The present invention relates to the targeted delivery of molecules to cells expressing toll-like receptors (TLRs). Aspects of the invention provide compounds comprising a positively charged group linked to a TLR ligand. These compounds are useful for in vitro and in vivo methods of transfection of TLR-expressing cells. Other aspects of the invention relate to the use of such compounds for repression of gene expression and DNA vaccination approaches.
JACKSON DAVID CHARLES [AU]; ZENG WEIGUANG [AU]; CHUA BRENDON YEW LOONG [AU]
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