Detection and Treatment of an Invasive Cancer Phenotype

A method for the inhibition, prevention or treatment of invasive/metastatic cancer in an individual in need thereof, comprises a step of treating the individual with an agent capable of attenuating the activity of protein selected from the group consisting of: STIPl; and ALDHlAl. Suitably, the invasive/metastatic cancer is pancreatic cancer, typically a metastases selected from the group consisting of: bone metastases; lung metastases; liver metastases; bone marrow metastases; breast metastases; and brain metastases. The agent is an agent that suppresses the expression of the protein, for example, siRNA, miRNA, shRNA, a ribozyme, or antisense oligonucelotide.

Patents:
WO 2,009,109,952

Inventor(s): WALSH NAOMI; O'DONOVAN NORMA [IE]; DOWLING PAUL [IE]; CLYNES MARTIN [IE]

Type of Offer: Sale



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