Medical Patents for Sale or License

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Orthopaedic Walker

A unique, patented Orthopaedic Walker for the treatment of broken metatarsals....
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Detection of Signaling Molecules in a Biological Environment

This Patent focus on the detection of bacteria and other pathogens within the medical or agricultural areas. The detection uses a unique method of detecting in real-time, in situ (within the field or on a person), the Quorum Sensing signaling molecules rather than the bacteria itself. These signalin...
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Methods for Prevention and/or Treatment of Capsular Contracture

J&E Solutions holds a US patent for the prevention and/or treatment of capsular contracture utilizing a repositioned topical ointment. The patent also encompasses the use of the product on fibrotic tissue with other etiologies as its formative basis. The topical composition is comprised of a pharmac...
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Genotypic tumor progression classifier and predictor

Actively dividing tumors appear to progress to a life threatening condition more rapidly than slowly dividing tumors. Assessing actively dividing tumors currently involves a manual assessment of the number of mitotic cells in a histological slide prepared from the tumor and assessed by a trained pat...
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Auto-regulation System for Intraocular Pressure

A device and system for controlling pressure via fluid exchange in the body is presented. The device and system may be used to control intraocular eye pressure. The system is comprised of four main components: a cannula, a sensor, a controller and a pump. The system works to engage in a fluid exchan...
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Osteotome System

A plurality of osteotomes that are linked together via a recess and a matching projection such that the osteotomes remain linked when used to manipulate bone....
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Endoscope System with Disposable Sheath

Listing Purpose We already have the product manufactured. Now we are seeking partners to license our product. Background Current conventional digestive endoscopy carries risk of deadly cross infections, and the reprocessing procedure is time consuming. To solve the problem, we developed an ant...
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Materials and Methods for Reduction of Protein tau and Treatment of Neurodegenerative Diseases

The subject invention provides a myricanol compound that is in predominant form of (+)-.alpha.R,11S-myricanol as compared to (-)-.alpha.S,11R-myricanol. In one embodiment, the (+)-.alpha.R,11S-myricanol is isolated from Myrica cerifera, and is in about 86% enantiomeric excess of (-)-.alpha.S,11R-myr...
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"Composition and Manufacturing Processes of a Toxicity Free Botanical Drug for Curative Treatment of Chronic Diseases"

This invention discloses composition and manufacturing processes of a toxicity free botanical drug formulation for curative treatment of chronic inflammatory diseases....
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Skin patch instrument for treating pain

A therapeutic patch for treating pain capable of compressing a tender area up to a boundary thereof and/or an entire induration with metallic grains or crushed stones by a treatment method in accordance with a classification determined after clarifying a site of pain by pressing a skin with a pressi...
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Medical Transcription System including Automated formatting means and associated method

I am looking to sell my ( Utility Patent) for Medical Transcription System including Automated Formatting Means and Associated Method ( For an upfront fee of $1 Million U.S. dollars plus a % of Royalties from all profits made.) This is a technology that automates Medical Transcription (of any form o...
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Full Pot - the Pot That Does the Lot

Introducing the ‘Full-Pot’. The unique design of the ‘Full-Pot’ bottle permits the use of the entirety of the contents, ensuring no waste. “The pot that does the lot” has an array of purposes: ideal for nail polishes, medicine, perfumes and essential oils. As a result, the multifunctional ‘Full-Pot...
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Methods for resection of a luminal structure

Provided is a method of resecting a luminal structure, such as a colon. A first luminal structure and a second luminal structure are defined by severing the original luminal structure. The second luminal structure is secured to the distal end of an elongate body disposed within the second luminal st...
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Asymmetric Disc Distracting Cage

An inter-vertebral cage with a wedge shape eccentrically located on the leading end of the cage. The ectopically shaped leading edge of this embodiment facilitates easier interbody spacer placement with less risk of nerve injury, as well as with likely decreased risk of destruction of the end plate ...
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Extending Tissue Preservation

A method of sustaining cells is provided. The method can include providing a non-perfluorocarbon cell storage medium, providing a pre-oxygenated liquid perfluorocarbon in contact with the storage medium, and placing the cells in contact with the storage medium but not in contact with the perfluoroca...
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Human Immunosuppressive Protein

A composition of an immunosuppressant protein (HISP) which is achieved by the steps of obtaining supernatant from hNT neuronal cells; exposing the supernatant to preparative polyacrylamide gel; placing the active isoelectric fraction on a Blue Sepharose column to bind albumin; and collecting the fre...
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Salmonella-based anti-cancer vaccine

We offer a technology of vaccine-based cancer therapy developed at the Jagiellonian University (Krakow, Poland). The immunotherapy is based on genetically modified bacterial strain of Salmonella VNP20009 that is able to target and preferentially colonise tumour tissue. Tumour targeting of VNP20009 w...
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Device for supporting a person in a sitting position.

Description of my product(what it is in non-technical terms):LAKLIFT(tm)is a device to relieve pain caused by spinal pressure while sitting. It works when nothing else would seem to be effective except surgery. LAKLIFT(tm) relieves back pain by reducing weight and pressure on the spine naturally....
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Topical Anesthetic for Expedited Wound Healing and Pain Relief

Heals cuts, burns, acute wounds, acute diabetic wounds, herpatic lesions, shingles rash, insect bites and stings, stomatitis, and radiation burns. Most lesions heal in 24 to 48 hours without infection or reported pain. University studied with pre-clinical and clinical trials. Topical has been pub...
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Quick-E Emergency ECG Electrode Chest Pad

A disposable ECG electrode chest pad that has pre-wired electrodes in the proper positions which can be applied in one step and easily connected to nearly any ECG machine with pre-existing adapters. It can be used in any setting an ECG would be used, in addition to being used to monitor patients in ...
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Device for Giving Liquid Medicine to Children

We own one US Patent #7654977 that we are interested in selling/auctioning. The protected device product has been developed and sold in Europe for delivering liquid medicines to infants and toddlers under the mark “MEDICINUS”. Please see some pictures below....
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Real Time Dose Verification in Radiotherapy

A team from the Universities of Bristol and Swansea together with University Hospitals Bristol NHS Foundation Trust has developed a novel radiation detector device for determining the dose from Intensity Modulated Radiotherapy (IMRT) in real time. The detector is positioned upstream of the patient (...
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“Deep” needle holder

Introduction: A number of open urological procedures demand deep and narrow surgical fields. This fact in correlation with special circumstances (like hemorrhage) makes many times the manipulation of a curved needle with a conventional needle holder very difficult, even for an experienced surgeon. ...
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Computer peripherals sterilization system

A KEYBOARD ADD-ON THAT PROVIDES A RULES-BASED, CONTROLLED PROCESS OF ELIMINATING BACTERIA AND GERMS FROM ANY EXISTING KEYBOARD, MOUSE, CELLPHONE, IPAD OR SIMILAR DEVICES IN 10 SECONDS OR LESS. EXISTING KEYBOARD CAN BE DISABLED TO GUARANTEE THE NEXT USER A FULLY STERILE ENVIRONMENT. FULLY USB CONTR...
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Special Bed for prevention of Bedsores

It is a BED for the totally INVALID person prone to BED SORES. The paraphrased abstract reads as follows: A specialized bed will prevent bedsores, heal existing bedsores, with no repositioning of person required. The bed is provided with a series of BANDS that can be made to be TAUT and horizon...
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Lined Balloon Mounted Stent

A stent that is implanted by catheter to narrow or occlude the lumen of any vessel in a graded reversible pattern as needed. May be used to perform patent ductus arteriosus closure in neonates, pulmonary artery banding, reverisble control or occlusion of bleeding aneurysms..etc in all age groups....
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Serotonin Transporter Gene and Treatment of Alcoholism

The gene responsible for encoding SERT has a functional polymorphism at the 5'-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in trea...
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Use of S-Nitrosothiol Signaling to Treat Disordered Control of Breathing

The present invention is directed to a method of treating disordered control of breathing including the treatment of apnea and hypoventilation associated with congenital or acquired brain stem abnormalities. Specifically the invention is directed to treating disordered control of breathing by admini...
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Combination of HGF Inhibitor and PTEN Agonist to Treat Cancer

The present invention is directed toward a method of treating cancer by administering to a patient an inhibitor of Hepatocyte Growth Factor and an agonist of PTEN....
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Method and System for Fusing a Spinal Region

A method and system for fusing a region in the spine involve the use of at least one guide tube to pass instruments and substances into the spinal region in a minimally invasive manner. In the preferred practice of the method, a guide tube is anchored to a vertebra and the guide tube is moved to the...
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Compositions and Methods for Treatment of Leukemia

The invention relates generally to effective treatment leukemia. In particular, the present invention provides compositions and methods to inhibit the interaction of menin with MLL and MLL-fusion oncoproteins, and well as systems and methods to screen for such compositions....
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Use of pramipexole to treat amyotrophic lateral sclerosis

The present invention is directed to compositions comprising pramipexole and the use of such compositions treat neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). As shown in Fig. 6B the mean + 1 -SEM serum 2,3-DHBA levels for the 12 ALS participants decreased significantly afte...
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Inhibiting CAV3 isoforms and the delta25B splice varients for the diagnosis and treatment of cancer

The present application is directed to an antibody that specifically binds to a Cav3 isoform or its '25 splicing variants thereof....
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L- OddC Prodrugs for Cancer

The main drawback in the use of most nucleoside anticancer agents originates from their hydrophilic nature, of which property requires a high and frequent dosage for an intravenous administration. Unlike other nucleoside anti-tumor agents, troxacitabine appears to predominantly enter tumor cells by ...
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Hybridoma Cell Lines and Monoclonal Antibodies Recognizing Anthrose Saccharide of Bacillus Anthracis

The present invention includes hybridoma cell lines and monoclonal antibodies that bind to the anthrose tetrasaccharide of Bacillus anthracis and methods using said antibodies....
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Antimicrobial Compositions and Methods of Use

Disclosed herein are antimicrobial compositions, kits, and articles of manufacture. Further disclosed herein are methods for treating surfaces, including tissue, inter alia, wounds, with the disclosed compositions....
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No-modified hemoglobins and uses therefor

Nitrosylhemoglobin can be produced by introducing gaseous NO into an aqueous solution of hemoglobin. It has been demonstrated that nitrosylhemoglobin in aqueous solution can be converted to SNO-hemoglobin upon introduction of oxygen to the solution, as is postulated to occur in the lungs. Nitrosylhe...
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Dual Specific Immunotoxin for Brain Tumor Therapy

We tested the in vitro and in vivo efficacy of a recombinant bispecific immunotoxin that recognizes both EGFRwt and tumor-specific EGFRvIII receptors. A single chain antibody was cloned from a hybridoma and fused to toxin, carrying a C-terminal peptide which increases retention within cells. The bin...
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Anti-Tumor Antibodies

Chondroition sulfate proteoglycans represent excellent targets for anti-tumor immunotherapy. Antibodies which target such proteoglycans can be used alone, in combinations, armed with a cytotoxic payload or unarmed. Combinations of such antibodies can target different epitopes of the proteoglycans. I...
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Vaccine Vectors

The present invention relates, in general, to recombinant viral constructs expressing a protective antigen and to vaccine compositions comprising same. The invention further relates to a method of inducing an immune response, for example, to human immunodeficiency virus (HIV)....
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Inhibiting Smad signaling promotes neuron regeneration

Regeneration of a lesioned CNS axon of a mature neuron, determined to be subject to regeneration inhibition by Smad2/3 signaling, is promoted by contacting the neuron with an inhibitor of Smad2/3 signaling sufficient to promote regeneration of the axon....
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Method for Augmenting the Effects of Serotonin Reuptake Inhibitors

A method of treating a subject for a serotonergic neurotransmission dysregulation disorder, comprises administering the subject a serotonin enhancer (e.g., a serotonin reuptake inhibitor) in an amount effective to treat the disorder; and concurrently administering the subject 5-hydroxytryptophan in ...
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Compositions and Methods for the Treatment of Seborrhea

Methods and compositions are provided for treating dermatological diseases, disorders, and pathologies, including seborrheic dermatitis, in a subject in need thereof. In some embodiments, methods are provided for the treatment of a dermatological disease, disorder, or pathology comprising, topically...
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Compositions for Tissue Repair/regeneration

The invention provides compositions and methods for cardiac repair and/or regeneration of tissues such as myocardium....
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Anti-CD19 Antibody Therapy for Autoimmune Disease

The invention relates to immunotherapeutic compositions and methods for the treatment of autoimmune diseases and disorders in human subjects using therapeutic antibodies that bind to the human CD19 antigen and that preferably mediate human ADCC. The present invention relates to pharmaceutical compos...
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Chronic Lymphocytic Leukemia Prognosis and Treatment

Provided herein are methods for identifying a subject afflicted with chronic lymphocytic leukemia who is responsive to treatment with a chemotherapeutic agent by detecting the presence or absence of at least one APOE4 allele in the subject, the presence of an APOE4 allele identifying the subject as ...
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Anti-CD19 Antibody Therapy for Transplantation

The invention relates to immunotherapeutic compositions and methods for the treatment and prevention of GVHD, humoral rejection, and post-transplantation lymphoproliferative disorder in human subjects using therapeutic antibodies that bind to the human CD19 antigen and that preferably mediate human ...
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Compositions and Methods for Treating Hair Loss Using Non-naturally Occurring Prostaglandins

A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth....
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Methods and Compositions to Identify Increased Risk of Breast Cancer by Detection of CPG Island Methylator Phenotype (CIMP)

The present invention is directed to kits and methods for identifying a female subject as having an increased risk of developing breast cancer, comprising detecting a CPG island methylator phenotype (CIMP) in nucleic acid of the subject....
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Cancer Therapy

PROBLEM TO BE SOLVED: To provide cancer therapy. ; SOLUTION: A method for preventing or treating cancer is provided. In the method, low molecular weight antioxidants [e.g., mimetics of superoxide dismutase (SOD)] are generally used in cancer therapy, especially as an active agent or as a chemo- and/...
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Reagent for Autoimmune Disease and Treatment

PROBLEM TO BE SOLVED: To provide a reagent for the treatment of autoimmune diseases and a method. ; SOLUTION: This invention relates to a treatment method using an anti-CD22 monoclonal antibody having specific physiological characteristics. Especially, this invention relates to a method of treating ...
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Xanthine Derivatives for the Treatment of Vascular Depression

Methods and compositions are provided for treating vascular depression. The methods involve administering to a subject in need thereof a xanthine derivative in a therapeutically effective amount to treat vascular depression, particularly the xanthine derivatives pentoxifylline or propentofylline. Th...
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Methods of Subclassification of Ductal Carcinoma of the Breast

Provided herein are methods of determining the aggressiveness or indolence of a ductal carcinoma in situ lesion. Also provided are methods of developing treatment plans for subjects with a ductal carcinoma in situ lesion based on the aggressiveness of the lesion....
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Prevention of Flap Necrosis in Plastic Surgery

PROBLEM TO BE SOLVED: To provide a method for resolving or preventing vasoconstriction and preventing depletion of blood flow or restoring blood flow in a pedicle flap or any other microsurgery. ; SOLUTION: The method for preventing necrosis in a pedicle flap or in any microvascular surgery comprise...
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Peripheral Reticular Pigmentary Change and Age-Related Macular Degeneration

Examination of 956 age-related macular degeneration cases showed that the complement factor H variant (Y402H, C allele at rs1061170) increases risk for the development of peripheral reticular pigmentary change. AMD phenotypes of 796 carriers of the CFH Y402H variant were compared to the AMD phenotyp...
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Implants with membrane diffusion controlled active ingredient release

Implant having a structure for implantation in a human or animal body, comprises implant base body, primer layer applied at least partially to the surface of the implant, active ingredient layer consisting of one or more active ingredients applied to at least a portion of the surface of the primer l...
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Stabilization of Cells By Ionic Liquids

The present invention relates to the use of ionic liquids and/or compatible solutes for storing and stabilizing eukaryotic cells, above all blood cells such as leukocytes, platelets, or erythrocytes. The invention further relates to compositions which comprise eukaryotic cells and ionic liquids and/...
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Implant and Bone Screw Having Interlocking Cams

The invention relates to a fixation device for bones, consisting of an implant (1; 11), having at least one through hole (2; 12), to be fastened to the bone, and of at least one bone screw (3; 13) to be fastened in said through hole (2; 12), fastening elements (5; 15) being arranged in the through h...
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Use of Plant Extracts Comprising Polyphenol for Treating Adiposity and Diabetes Mellitus Type 2

The present invention relates to the use of plant extracts comprising polyphenol for treating adiposity and diabetes mellitus type 2. The extracts comprise specific polyphenol compounds, in particular procyanidin A3 isomers. The invention further relates to methods for producing extracts of said kin...
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Bioequivalence Dialysis

The present invention relates to a method for treating blood disorders and blood disorders compensation. This includes steps in which one blood or blood plasma of a patient outside the body brings with a second liquid (bioequivalent) in contact with the second liquid blood or blood is modified, whic...
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Combination of an antibody and a bacterium, which expresses Fc-receptors or proteins, which bind the light chain of an antibody, useful for the treatment of tumors and their precursors, preferably col

Combination of at least one antibody and a bacterium, which expresses Fc-receptors or proteins, which bind the light chain of an antibody, is claimed, where at least one antibody is bound via its Fc-region to an Fc-receptor of the bacterium or via its light chain to protein of the bacterium, which b...
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Bioequivalence Dialysis

The present invention relates to a method for treating blood composition disorders and blood function disorders. Said method comprises steps, in which blood or blood plasma of a patient is brought into extracorporeal contact with a second fluid (bioequivalent), wherein said second fluid is blood or ...
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Use of Opioids Or Opioid Mimetics for the Treatment of Resistant Cancer Patients

The use of opioids or opioid mimetics is suggested for the manufacture of a medicament for the treatment of resistant cancer patients....
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Inhibiting GSNOR

Treatment of myocardial infarction to reduce infarct size and organogenesis is provided by administration of agents selected from the group consisting of:...
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Method of Providing Neuroprotection Using Substituted Porphyrins

Described herein are methods of treating ischemic injury comprising administering to a subject in need thereof a therapeutically effective amount of a substituted porphyrin compound. Also disclosed are methods of providing neuroprotection, methods of treating subarachnoid hemorrhage, methods of trea...
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3,28-disubstituted Betulinic Acid Derivatives As Anti-HIV Agents

Compounds according to Formula (I) are described along with compositions containing the same and methods of use thereof for the treatment of viral infections....
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Methods of Treating Lung Disease and Other Inflammatory Diseases

A method of treating an inflammatory disease in a subject in need thereof is carried out by administering the subject a gastrin-releasing peptide (GRP) inhibitor in a treatment effective amount. Suitable GRP inhibitors include compounds of the general formula (I) and pharmaceutically acceptable salt...
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Predicting Coronary Artery Disease and Risk of Cardiovascular Events

Methods of assessing the risk of cardiovascular disease in a subject by detecting the level of at least one metabolite in a sample from the subject are disclosed herein. The level of the metabolite is indicative of the risk of cardiovascular disease in the subject. The metabolites may be acylcarniti...
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Prevention of Receptor Desensitization

PROBLEM TO BE SOLVED: To provide a method for treatment of diseases relating to G protein receptor kinase activity or patients under pathological conditions of the same. ; SOLUTION: The desensitization of a receptor controlling the diseases can be prevented by inhibition of the G protein receptor ki...
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Methods and Compositions for Regulating HDAC6 Activity

The present invention provides methods and compositions for inhibiting Hsp90 activity in a cell, comprising contacting the cell with an inhibitor of histone deacetylase 6 (HDAC6)...
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Treatment of glycogen storage disease type II

Methods of treating glycogen storage disease type II, by administering acid alpha -glucosidase, are described, as are compositions for use in treatment of glycogen storage disease type II....
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Compositions and Methods for Modulating S-nitrosogluthione Reductase

Disclosed herein are methods and compositions for modulating the levels and/or activity of S-nitrosoglutathione reductase (GSNOR) in vivo or in vitro. Specifically disclosed are GSNOR deletion constructs, host cells and non-human mammals comprising GSNOR deletions, and methods of screening employing...
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Use of Hasf As a Protective Agent Against Ischemic Tissue Damage

A method of inducing a protective response against ischemic tissue damage is carried out by administering to subject a composition comprising an HASF polypeptide. The composition is administered prior to an ischemic event such as myocardial infarction to reduce tissue damage associated with such an ...
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Neuroactive Steroid Compositions and Methods of Use Therefor

Provided are methods for ameliorating a symptom of a neuropsychiatric disorder in a subject. Also provided are methods for ameliorating at least one physical symptom or at least one psychological symptom resulting from tobacco cessation in a subject, methods for ameliorating a symptom of Alzheimer's...
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Compositions and Methods for Promoting Nasal Patency and Treating Neurogenic Bladder Using Prostaglandins

The invention provides methods for maintaining or promoting patency (e.g., nasal patency) comprising administering to a subject in need thereof an effective amount of at least one prostaglandin F analog (PGF) as described herein, methods for relieving nasal congestion comprising administering to a s...
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Forming Iron Nitrosyl Hemoglobin

Contrary to current opinion that nitrite in general oxidizes hemoglobin with elimination of active nitric oxide, deoxygenated hemoglobin reacts with low concentration inorganic nitrite to produce very stable iron nitrosyl hemoglobin which on delivery into the body is converted to a hemoglobin capabl...
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Method of Treating Glycogen Storage Disease

The present invention relates, in general, to Glycogen Storage Disease and, in particular, to a method of treating Glycogen Storage Disease-type-III and to compounds and compositions suitable for use in such a method....
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Improved Device and Method for Delivery of a Medicament

The disclosure relates to an improved method of enhancing nicotine concentrations in a gaseous carrier. The methods are adaptable to the delivery of nicotine for therapeutic effect in various diseases, in particular nicotine for tobacco product use cessation, substitution and/or harm reduction. The ...
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Treatment of Wnt/frizzled-related Diseases

Methods of treating Wnt/Frizzled-related diseases, comprising administering niclosamide compounds are provided. Methods of predicting whether a disease will respond to treatment with a niclosamide compound are also provided....
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Smoothened Receptor Modulators

The present invention relates, in general, to the Smoothened receptor and, in particular, to a method of modulating Smoothened receptor activity and to compounds and compositions suitable for use in such a method....
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Compositions and Methods for Inhibiting Hair Growth

A method for inhibiting hair growth in mammals using compositions containing FP receptor antagonists (e.g., prostaglandin F analogs that are block activation of the FP receptor). The compositions can be applied topically to the skin and/or hair. The compositions can arrest hirsutism or hypertrichosi...
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Use of an Agent That Restores Tissue Perfusion and Oxygenation

The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemother...
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Inhibition of HIF-1 activation for anti-tumor and anti-inflammatory responses

The presently disclosed subject matter generally relates to methods and compositions for inhibiting the expression and/or activation of hypoxia-inducible factor 1 (HIF-1) genes in a cancer cell, tissue or tumor. More particularly, the methods disclosed herein relate to inhibition of HIF-1 activation...
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Compositions and Methods for the Treatment of Radioresistant Glioma Stem Cells

Compositions and uses of gamma secretase inhibitors (GSIs) for the treatment and inhibition of gliomas in subjects in need thereof are provided. Methods for administering gamma secretase inhibitors in association with radiation for the treatment of radiation resistant gliomas are described. Composit...
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Stem Cell Derived Factors for Treating Pathologic Conditions

A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic condtions....
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Substituted porphyrins and their therapeutic use

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and composit...
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Novel Medical Uses for No and No Donor Compounds

A body part is preserved using nitric oxide and/or a nitric oxide donor that does not directly release nitric oxide or a red blood cell nitrosylating agent, preferably ethyl nitrite to facilitate oxygen supply. A subject at risk for developing high altitude illness is administered a red blood nitros...
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Inhibition of Inter-alpha Trypsin Inhibitor for the Treatment of Airway Disease

It is disclosed herein that blockade of inter-alpha-trypsin inhibitor (IaI) prevents the development of airway hyperresponsiveness in animal models of asthma and chronic obstructive pulmonary disease. Provided herein are methods of treating an airway disease or disorder in a subject by administering...
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Methods and Compositions for Treating Urinary Tract Infections Using Agents That Mimic Or Elevate Cyclic Amp

Methods and compositions are provided for treating a urinary tract infection (UTI). The methods involve administering to a subject in need thereof a cAMP elevator or agent that mimics cAMP, particularly a labdane diterpene such as forskolin or a derivative or analog thereof in a therapeutically effe...
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Systems and Methods for Determining Hemoglobin Concentration Utilizing Diffuse Reflectance At Isosbestic Wavelengths

Systems and methods for determining hemoglobin concentration utilizing diffuse reflectance at isosbestic wavelengths are provided. In one embodiment, the method includes emitting light onto a tissue mass, measuring diffuse reflectance from the tissue mass, and calculating a ratio of diffuse reflecta...
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Inhibiting GS-FDH to Modulate No Bioactivity

Patients needing NO donor therapy or inhibition of pathologically proliferating cells or increased NO bioactivity are treated with a therapeutically effective amount of an inhibitor of glutathione-dependent formaldehyde dehydrogenase....
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Anti-lipid Antibodies

The present invention relates, in general, to anti-lipid antibodies and, in particular, to methods of inhibiting HIV-I infection using anti-lipid (e.g. anti-phospholipid) antibodies....
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A Method of Detecting Antibodies and Antibody-hiv Virion Complexes

The present invention relates, in general, to HIV and, in particular to a method of detecting anti-HIV antibodies and antibody-HIV virion complexes....
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Treatment for Diseases Relying on Discovery That Thioredoxin Mediates Nitric Oxide

Patients having a disease associated with high level of thioredoxin system activity or a requirement for nitric oxide, e.g. large cell lymphoma or restenosis, are treated with a thioredoxin reductase inhibitor, e.g. auranofin or arsenic trioxide, and a nitric oxide donating compound, e.g. isosorbide...
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Reversible Platelet Inhibition

The present invention relates, in general, to receptors and to platelet aggregation and, in particular, to a method of inhibiting platelet aggregation using an aptamer that binds to and inhibits the activity of a receptor, such as glycoprotein IIb/IIIa (gpIIb/IIIa), and to aptamers suitable for use ...
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Therapeutic Agents for Neurodegenerative Diseases

Methods of treating diseases involving protein aggregation are provided. Methods of identifying and selecting an autophagosome/lysosome fusion enhancer are also provided....
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Methods of Treating Disease-induced Ataxia and Non-ataxic Imbalance

Methods for treatment of disease-induced ataxia and non-ataxic imbalance are disclosed. The methods involve treating a patient with a compound having nicotinic acetylcholine receptor activity....
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Method of Treating Chronic Myelogenous Leukemia Cells

Here, the inventors disclose the treatment of imatinib mesylate resistant chronic myelogenous leukemia cells with a cotreatment of vorinostat (SAHA, suberoylanilide hydroxamic acid) and dasatinib, a dual Abl/Src kinase (TK) inhibitor. Combined treatment of cultured human CML and BaF3 cells with vori...
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Delta-tocotrienol Treatment and Prevention of Pancreatic Cancer

Methods are disclosed for treating neoplastic disorders, such as pancreatic cancer, using tocotrienols; namely, gamma-tocotrienol and delta tocotrienol. The antitumorogenic effects of these compounds are shown both in vitro and in vivo using several human pancreatic cancer cell lines and MIA-PAC A2 ...
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Materials and Methods for Treating Allergic and Inflammatory Conditions

The subject invention provides for the utilization of bone-marrow derived stem cells in the treatment of allergic and inflammatory diseases. In one embodiment, the invention provides for treatment of asthma. Bone-marrow derived stem cells can be used for decreasing inflammation and alter the course ...
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Urodilatin Cancer Treatment

Urodilatin, a peptide formed in the kidney, has significant anticancer effects eliminating two-thirds of cancer cells within 24 hours....
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Bone marrow-derived neuronal cells

Bone marrow stromal cells (BMSC) differentiate into neuron-like phenotypes in vitro and in vivo, engrafted into normal or denervated rat striatum. The BMSC administered into the ventricle did not remain localized to the site of the graft, but migrated throughout the brain and integrated into specifi...
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Prevention, Treatment, and Diagnosis of Alzheimer's Disease Through Electromagnetic Field Exposure

According to a first embodiment the invention includes a method of treating a neurological disorder, such as Alzheimer's Disease, in a subject in need thereof by positioning an electromagnetic field emitting source proximal to the subject and exposing the subject to an electromagnetic field having a...
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Compositions and Methods for Enhancing Neuroprotection Via Administration of Stem Cells and Blood Brain Barrier Permeabilizers

The present invention provides compositions and methods for enhancing the neuroprotective effect of umbilical cord blood cells. More particularly, the present invention provides methods of treating neurodegenerative disorders by administering umbilical cord blood cells and a substance capable of per...
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Hucbc Treatment of Amyloid Associated Disease

Administration of human umbilical cord blood cells (HUCBC) or HUCBC-derived plasma is used to treat amyloid-based diseases, such as Alzheimer's disease, Huntington's disease, cerebral amyloid antigopathy, and type-II diabetes. Modulating inflammatory reactions by infusing HUCBC resulted in a marked ...
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Reelin Rescues Cognitive Function

Disclosed are methods of influencing, and enhancing, cognitive function by increasing, and/or preventing interference with, Reelin levels as well as Reelin signaling. Cognitive function is improved, in a subject in need thereof, by administering a therapeutically effective amount of Reelin, a Reelin...
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Inhibitors of Akt/PKB with Anti-tumor Activity.

The subject invention concerns materials and methods for inhibiting the Akt/PKB pathway. In one embodiment, a compound of the invention inhibits kinase activity and/or phosphorylation levels of Akt proteins. The subject invention also concerns methods for inhibiting or killing a cancer cell or other...
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Control of Nk Cell Function and Survival By Modulation of Ship Activity

Inhibition of dendritic cell function in solid organ grafts or allogeneic bone marrow transplants prior to or during engraftment by blocking SH2-containing inositol phosphatase (SHIP) expression or function is taught as a method of abrogating immune rejection and thereby increasing the efficacy of e...
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Methods of Diagnosing and Treating Cancer.

The invention relates to methods of determining an appropriate cancer therapy for a subject based on intratumoral expression levels of Ribonucleotide Reductase M1 (RRM1) and thymidylate synthase (TS) gene expression, as well as to methods of predicting clinical outcome (prognosis) based on cytoplasm...
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Neurodegenerative Disease Treatment Using JAK/STAT Inhibition

The invention relates to treatment of neurodegenerative diseases with JAK/STAT pathway inhibitors to eliminate extracellular cell signaling events leading to cell cycle abrogation and/or apoptosis. Primary neurons were administered neurotoxic proteins, such as gp120, Tat, or gp120 and Tat, with or w...
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Materials and methods for diagnosis, prevention and/or treatment of stress disorders and conditions associated with abeta peptide aggregation

The subject invention concerns materials and methods for treating and/or preventing diseases associated with accumulation of A[beta] peptide in neural tissue. The subject invention also concerns materials and methods for treating and/or preventing stress disorders, such as post-traumatic stress diso...
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Methods of Detecting and Treating Colon Disorders

The subject invention pertains to a method of detecting colon disorders including inflammatory bowel disease, such as Crohn's disease and ulcerative colitis, based on underexpression of Lipopolysaccharide Responsive Beige-like Anchor (LRBA). Advantageously, the invention may be used to test for infl...
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N,n'-di-p-bromophenyl Guanidine Treatment for Stroke At Delayed Timepoints

1,3 di-o-tolylguanidine (DTG) was examined as anti-stroke drug with a broad therapeutic window. DTG activates sigma 1 and 2 receptors. Administration of DTG at 24 hours post- stroke to rats reduces neurodegeneration by 85%; this is the only pharmacological agent that has been used successfully at th...
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Methods of Treating Stroke Using Stem Cell-like Menstrual Blood Cells

A cell type that is a complete match of the transplant recipient appears as an optimal scenario to open treatment options to a large patient population with minimal complications. The use of autologous bone marrow or umbilical cord blood has been proposed as a good source of stem cells for cell ther...
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A Method and Composition Using a Dual Specificity Protein Tyrosine Phosphatase As an Antimalarial Drug Target

Phosphotyrosine phosphatase (PTP) encoded by PF13_0027 is a desirable drug target for the human malaria parasite Plasmodium falciparum. This PTP is critical for intraerythrocytic parasite development and invasion of erythrocytes by malaria merozoites. Mutation of the PF13_0027 gene or blocking expre...
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CT Atlas of the Brisbane 2000 System of Liver Anatomy for Radiation Oncologists

The method includes the steps of obtaining atlas data in an atlas coordinate set from a computer-readable atlas of hepatic anatomical information including three orders of division. The three orders of division include a first order separating the liver into two (right and left) hemi-livers, a secon...
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Individualized Cancer Treatments

The invention provides for compositions and methods for predicting an individual's responsitivity to cancer treatments and methods of treating cancer. In certain embodiments, the invention provides compositions and methods for predicting an individual's responsitivity to chemotherapeutics, including...
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Combination of Insulin and Ascorbate to Enhance Wound Healing

Provided is a method of stimulating collagen synthesis and proteoglycan (lumican and keratocan) accumulation. Collagenase isolated keratocytes were cultured with or without insulin with or without ascorbate. Insulin stimulates the synthesis of collagen but does not affect the accumulation of lumican...
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Method of Rapidly Visualizing Essential Neural Pathways

A method of optimizing pre-operative procedures in the field of neurosurgery. The method facilitates the identification of essential fiber tract pathways that must be avoided when planning and performing an operation, thereby increasing surgical safety and avoiding complications. The method includes...
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Materials and Methods for Prevention and Treatment of RNA Viral Diseases

The subject invention concerns a method of inhibiting an RNA virus infection within a patient by increasing the amount of 2-5 oligoadenylate synthetase (2-5 AS) activity within the patient. Preferably, the preventative and therapeutic methods of the present invention involve administering a nucleoti...
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Leukemia Treatment Method and Composition

A method of inducing high anti-leukemia activity responsive to the combination of hydroxamic acid analogue histone deacetylase inhibitors and PKC412 against human acute leukemia characterized as expressing phosphorylated (p)FLT3 kinase by a novel flow cytometry-based assay....
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Synergistic Modulation of Microglial Activation by Nicotine and THC

Treatment of microglial cells with nicotine and THC synergistically attenuate the microglial activation. Using microglial activation, the combination of THC and nicotine interact synergistically reduced LPS induced TNF-[alpha] release, showing that the combination of THC and nicotine clinically have...
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Materials and Methods for Capture of Pathogens and Removal of Aurintricarboxylic Acid from a Sample

The present invention concerns methods and materials for extracting infectious pathogens from a sample, such as blood, comprising the steps of creating a fibrin aggregate confining the pathogens and introducing a fibrin lysis reagent to expose the pathogens for analysis. The fibrin lysis reagent is ...
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Methods of Treating Cognitive Impairment

The subject invention concerns materials and methods for treating a person or animal having cognitive impairment. In one embodiment, the method comprises administering an effective amount of one or more inflammatory mediator(s), for example, fms-related tyrosine kinase 3 (Flt3) ligand, interleukin-6...
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Tissue Classification Method for Diagnosis and Treatment of Tumors

The present invention discloses an informational computation method for classifying objects Specifically, the invention is a system, method, and computer-readable media for classifying tumors using a nonparametric statistical classifier in conjunction with an artificial neural network. The invention...
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Ship-deficiency to Increase Megakaryocyte and Platelet Production

A method of increasing megakaryocytes and platelet numbers in a patient comprising the step of inhibiting SHIP expression, including SHIP's enzymatic activity and signaling functions, whereby normal blood clotting is induced....
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Anticancer Combination Therapy Including Triciribine

This invention encompasses combination therapies including TCN, TCN-P, TCN-PM and/or related compounds and one or more additional anti-cancer agents, for example, taxanes a molecule that modulates the HER2/neu (erbB2) receptor, anthracyclin compounds, epidermal growth factor receptor inhibitor compo...
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Method of Treating Peripheral Nerve Sensory Loss Using Compounds Having Nicotinic Acetylcholine Receptor Activity

Methods for treatment of peripheral nerve sensory loss are disclosed. The methods involve treating a patient with a compound having nicotinic acetylcholine receptor activity....
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Sterile Inflatable Drape

A sterile inflatable drape includes a base having a size and shape adapted to cover a surgical site. A peripheral border surrounds the base. The base and the peripheral border have a first side covered with a releasable adhesive adapted to releasably engage a patient's skin when the base and periphe...
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Reatment of Suicidal Ideation Or Behavior Using Inhibitors of Nicotinic Acetylcholine Receptors

The invention concerns methods of treating suicidal ideation or behavior in a subject in need thereof, comprising decreasing endogenous nicotinic acetylcholine receptor (nAChR) activity in the subject; therapeutic packages for treating suicidal ideation or behavior; and methods for determining the e...
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Cancer imaging and treatment

A compound, or a pharmaceutically acceptable salt or ester thereof, comprises a ligand for the chemokine receptor CXCR4 and a detectable label, the ligand having a binding affinity for the CXCR4 receptor, measured as IC50 in the presence of I-CPCR4, of 25OnM or lower, wherein the ligand comprises a ...
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Trocar Tube, Trocar, Obturator, Or Rectoscope for Transluminal Endoscopic Surgery Via Natural Body Cavities

The present invention relates to a trocar tube, trocar, obturator, rectoscope for transluminal endoscopic surgery via natural body cavities. A trocar tube (2) according to the invention is provided, having a distal section (22) for positioning at least in the region of or outside the body cavity, an...
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Radiolabeled Monomeric and Multimeric Cyclic Oligopeptides Binding to the CXCR4 Receptor for Cancer Imaging and Treatment

A compound, or a pharmaceutically acceptable salt or ester thereof, comprises the structure: [(P1-S1j)p - L - (S2q-P2)r]t wherein: P1 and P2, which may be the same or different, are cyclic oligopeptide moieties, at least one of P1 and P2 having the motif B-Arg or B-(Me) Arg within the cyclic moiety,...
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Fibroblast growth factor (fgf23) and methods for use

The invention relates to nucleic acids encoding a fibroblast growth factor-23 (FGF23) and proteins encoded thereby, mutations in which are associated with autosomal dominant rickets (ADHR). The invention further relates to methods of diagnosing and treating hypophosphatemic and hyperphosphatemic dis...
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Minimized Small Peptides with High Affinity for Factor VIII and Factor VIII-like Proteins

The present invention relates to the composition of small molecules and their use in the field of protein isolation, purification, stabilizing and/or enhancing its activity. In particular, the present invention relates to the synthesis and optimization of compounds comprising small peptides and pept...
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Trocar Tube, Trocar, Obturator, Or Rectoscope for Transluminal Endoscopic Surgery Via Natural Body Cavities

The present invention relates to a trocar, trocar, obturator, Rektroskop for the transluminal endoscopic surgery via natural orifices. A trocar according to the invention is provided with a distal portion for positioning at least in the region or outside the body opening and a proximal portion for p...
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Multiple N-methylated Cyclic Hexapeptides for Treatment of Neurogenic Inflammation

The present invention relates to cyclic hexapeptides containing two or more N-alkyiations in their backbone. The described cyclopeptides are active as anti-inflammatory agents and/or analgesics and may be used for the treatment of neuropathic pain and/or neurogenic inflammation....
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Use of an Ozone/oxygen Mixture As Primary Anticancer Therapy Through Intraperitoneal Insufflation

Squamous cell carcinomas of the ENT area (HNSCC) are a group of metastatic tumors with a high mortality rate in humans and animals. Since then discovered that the biomolecule ozone inhibits the growth of various cancer cells in vitro, we here applied the highly aggressive and lethal VX2 carcinoma HN...
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Methods for the Treatment of Viral Conditions

The invention is directed to a method of stimulating PRF in a viral cell by administering an aminoglycoside antibiotic to said cell. In another embodiment, the invention is directed to a method of inhibiting viral replication by administering an aminoglycoside antibiotic to a viral cell. The inventi...
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Methods and Compositions for Facilitating Tissue Repair and Diagnosing, Preventing, and Treating Fibrosis

Compositions and methods for facilitating tissue repair by enhancing the actions of BIGH3 or at least one of its downstream effector molecules in injured tissue, and for the diagnosis, prophylactic and therapeutic treatment of fibrosis by inhibiting the actions of BIGH3 or at least one of its downst...
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Aminoflavone (nsc 686288) and Combinations Thereof for Treating Breast Cancer

Disclosed are methods of treating breast cancer by administering to a mammal aminoflavone, and optionally one or more additional anti-cancer agents. According to example embodiments, the methods include methods of treating cancers resistant to endocrine therapy....
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Methods of Treating a Microbial Infection By Modulating RNase-L Expression And/or Activity

The invention relates to methods and compositions for treating a microbial infection. In the present invention, RNase-L activity has been shown to play an integral role in innate immunity and for defense against invading microbes. The present invention is drawn to exploiting the role of RNase-L in i...
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Small Molecule Inhibitors of Lck SH2 Domain Binding

The present invention provides, materials and methods for modulating an immune response. The materials and methods may be used to treat diseases associated with an aberrant immune response. In some embodiments, materials and methods of the invention may be used to treat autoimmune diseases, for exam...
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Inhibitors of NCCa-ATP Channels for Therapy

Methods and compositions are provided that are utilized for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN), particularly following spinal cord injury. In particular, the methods and compositions are inhibitors of a particular NCca-ATP channel and...
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Potent Inhibitory Effect of Zinc in Combination with Sulforaphane on Cancer Cell Growth

This invention relates to compositions comprising zinc and sulforaphane which can be used in the treatment or prevention of cancer. The invention also relates to methods of treating or preventing cancer, including prostate cancer, which comprises the administration of zinc and sulforaphane to a pati...
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Methods for Regulating Urinary Potassium

The internalization sequence at the C-terminal end of the ROMK protein has been identified and sequenced. It has been discovered determined that endocytosis is triggered by binding of the ROMK internalization sequence to ARH protein, which is co-localized and expressed with ROMK. New methods of trea...
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Compositions and Methods of Inducing Endoplasmic Reticulum Stress Reponse

The present invention provides methods of inducing cell cycle arrest and/or cell growth inhibition, with the methods comprising administering to the cells an effective dose of the compounds of the present invention....
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Docosahexaenoic Acid for the Treatment of Heart Failure

There is currently no completely effective treatment for heart failure. Considering the need for, and current void in the medical field for, a treatment for heart failure, the invention is drawn to treating heart failure. In particular aspects, the invention is drawn to the discovery that certain po...
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Methods of Treating a Diabetic Embryopathy

Maternal diabetes can lead to a developmental malformation of an embryo. A developmental malformation caused by maternal diabetes is commonly referred to as a diabetic embryopathy. There is currently no effective treatment for reducing or inhibiting a diabetic embryopathy. To this end, the present i...
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Methods for Treating Central Pain Syndrome and Other Pain Related Pathologies

Central pain syndrome (CPS) is a debilitating condition that affects a large number of patients with a primary lesion or dysfunction in the central nervous system. Despite its discovery over a century ago, the pathophysiology underlying the development and maintenance of CPS is poorly understood. Th...
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EGRF and PAR2 Regulation of Intestinal Permeability

The present invention provides a method of treating an autoimmune disease, comprising the steps of increasing transepithelial electrical resistance leading to decreased cell permeability. Further provided is ajnethod of treating celiac disease in an individual in need of such treatment, comprising t...
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Derivatives of APF and Methods of Use

Derivatives of a novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the compounds for identifying and/or treating interstit...
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In Vivo Biofilm Infection Diagnosis and Treatment

The present invention relates to a method for in vivo detection of a biof?lm infection residing in a mammal, the method comprising (i) administering to the mammal a diagnostic-effective amount of a biofilm-specific probe, wherein the probe comprises a bio film-targeting moiety and a paramagnetic nan...
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Method of Treating Organophosphorous Poisoning

The present invention is directed to various methods for treating organophosphorus poisoning in an animal that is at risk of exposure to an organophosphorus compound or preventing organophosphorus poisoning in an animal that has been exposed to an organophosphorus compound, by administering a therap...
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Derivatives of Apf and Methods of Use

Derivatives of bladder epithelial antiproliferative factor and methods of using them are disclosed. In specific embodiments, the glycopeptide compositions are useful for the treatment and/or prevention of medical conditions, including cancer. In other embodiments, there are compositions and methods ...
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Sur1 Inhibitors for Therapy

Methods and compositions are provided that are utilized for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN). In particular, the methods and compositions are inhibitors of a particular NCca-ATP channel and include, for example, inhibitors of SUR1 a...
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Monoclonal Antibodies for Treatment of Cancer

The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, and hepatocellular cancer....
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Monoclonal Antibodies Against Claudin-18 for Treatment of Cancer

The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDl 8, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, ...
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Identification of Tumor-associated Markers for Diagnosis and Therapy

The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases....
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Use of RNA for Reprogramming Somatic Cells

The present invention provides methods for de-differentiating somatic cells into stem-like cells without generating embryos or fetuses. More specifically,-the present invention provides methods for effecting the de-differentiation of somatic cells to cells having stem cell characteristics, in partic...
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Methods Involving MS4A12 and Agents Targeting MS4A12 for Therapy, Diagnosis and Testing

The invention relates to methods involving MS4A12 and agents targeting MS4A12 which are useful for therapy, diagnosis and testing of disease states, in particular cancer diseases. In particular, the invention relates to agents which reduce or inhibit expression or activity of MS4A12, compositions co...
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Use of Flt3 Ligand for Strengthening Immune Responses in Rna Immunization

The invention relates to supplying vaccine RNA to cells. The invention relates in particular to a common use of vaccine RNA and Flt3 ligand for inducing, creating or enhancing an immune response when administered to animals (including humans)....
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Methods and Compositions for Diagnosis and Treatment of Cancer

The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which represent targets for therapy or diagnosis of tumor diseases in a subject....
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Identification of Tumor-associated Markers for Diagnosis and Therapy

The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases....
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Monoclonal Antibodies for Treatment of Cancer

The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast Cancer, lung Cancer, gastric Cancer, ovarian Cancer, hepatocellular Cancer, colon Cancer, pancreatic Cancer...
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Vaccine Composition Comprising 5'-cap Modified RNA

The present invention relates to modification of RNA with 5 '-cap analogs in order to improve the stability and increase the expression of said RNA, in particular in immature antigen presenting cells. The present invention provides a vaccine composition comprising said stabilized RNA, immature antig...
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Antibodies Specific for Claudin 6 (CLDN6)

The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin ca...
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Delivery of Transthyretin Across the Blood-brain Barrier As a Treatment for Alzheimer's Disease

The invention provides a composition comprising transthyretin and an ICAM-1 targeting agent, wherein the transthyretin and ICAM-1 targeting agent are coupled together, as well as methods of preparing such compositions. The invention further provides a diabody capable of binding specifically to ICAM-...
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Advanced Functional Biocompatible Foam Used As a Hemostatic Agent for Compressible and Non-compressible Acute Wounds

A sprayable polymeric foam hemostat for both compressible and non-compressible (intracavitary) acute wounds is disclosed. The foam comprises hydrophobically-modified polymers, such as hm-chitosan, or other amphiphilic polymers that anchor themselves within the membrane of cells in the vicinity of th...
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Identification of tumor-associated antigens for diagnosis and therapy

The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases....
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Methods and Compositions for Inhibiting Angiogenesis

The present invention relates to methods and compositions for modulating angiogenesis. In particular, the present invention relates to Pigment Epithelial-derived Factor (PEDF) fragments for use in modulating angiogenesis and treating angiogenesis mediated disease....
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Compositions and Methods for Treatment, Research and Therapeutic Applications for Malaria

The present invention provides anti-Plasmodium immunogenic compositions comprising EVP1 (PFD0495c) or an antigenic portion thereof, as well as methods of immunizing against malaria employing these compositions. In other embodiments, the present invention provides methods of identifying Plasmodium in...
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Method of Regulating the Heat Shock Response

The present invention is directed to method of modulating a heat shock response in a first cell of a multicellular organism comprising stimulating or inhibiting an HSR signaling activity of a second cell, wherein the second cell is a neuronal cell that regulates heat shock response activation in the...
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Compositions and Methods for Treating Atrial Fibrillation

The present invention provides compositions and methods for treating heart conditions. In particular, the present invention provides compositions and methods that block G protein coupled receptor mediated signaling for treating atrial fibrillation....
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Compositions and Methods for Treating Bone Formation Disorders

The present invention relates to compositions and methods for the detecting, treating, and empirically investigating disorders associated with bone formation (e.g., osteoporosis). In particular, the present invention provides compositions and methods for using maspin and targets of maspin in the dia...
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Delivery Scaffolds and Related Methods of Use

The present invention relates to delivery systems. In particular, the present invention provides microporous scaffolds having thereon agents (e.g., extracellular matrix proteins, exendin-4) and biological material (e.g., pancreatic islet cells). In some embodiments, the scaffolds are used for transp...
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Methods and Compositions for Modulating Calcium Channels

The present invention relates to methods and compositions for modulating calcium channels. In particular, the present invention provides methods and compositions for modulating (e.g., disrupting) Cav1.3a calcium channels for research and therapeutic methods (e.g., treating dopaminergic diseases and ...
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Use of SCF and G-CSF in the Treatment of Cerebral Ischemia and Neurological Disorders

The present invention relates to the use of stem cell factor (SCF) polypeptide, alone and in combination with granulocyte colony stimulating factor (G-CSF) polypeptide, in the prevention or treatment of injury to the brain after cerebral ischemia or neurological disorder. More particularly, the inve...
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Cardiac Pacing Lead and Delivery Sheath

The present invention provides compositions and methods related to epicardial pacing systems. In particular, the present invention provides a novel delivery sheath and cardiac pacing lead to be deployed in the pericardial space via a percutaneous approach....
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Method for Removal Or Inactivation of Heparin

The present invention relates to the use of immobilized RAGE or portions thereof for removal of heparin and low molecular weight heparin from a fluid sample or from a patient in need of neutralization of anticoagulant activity. The invention provides a method for removal or inactivation of heparin a...
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Pathogenecity Islands of Pseudomonas Aeruginosa

Disclosed are Pseudomonas aeruginosa Genomic Island nucleic acid sequences referred to as PAGI-5, PAGI-6, PAGI-7, PAGI-8, PAGI-9, PAGI-10, and PAGI-11. These nucleic acid sequences may be useful in methods for identifying virulent strains of Pseudomonas bacteria....
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Cardioprotective Role of Hepatic Cells and Hepatocyte Secretory Factors in Myocardial Ischemia

The present invention provides methods, compositions, and systems for treating a subject at risk for, with, or suspected of having, myocardial ischemia using hepatocyte secretory factors (e.g., AGP2, BMPER, FGF21, NRG4, and/or TFF3) or using factors that promote liver cell migration to ischemic myoc...
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Sealants for Membrane Repair

The present invention provides a method for preventing or repairing damage to a fetal membrane. In one embodiment, the method comprises contacting a fetal membrane with a composition comprising a four-armed catechol-terminated polyethylene glycol (cPEG) and a biocompatible oxidant, hi one embodiment...
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Polyvalent Polynucleotide Nanoparticle Conjugates As Delivery Vehicles for a Chemotherapeutic Agent

The present invention is directed to compositions and methods of delivering a chemotherapeutic agent via a polynueleotide-functionalized nanoparticle (PN-NP)....
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Methylation Profile of Neuroinflammatory Demyelinating Diseases

The present invention relates to compositions and methods for diagnosing neuroinflammatory demyelinating diseases, including but not limited to, multiple sclerosis. In particular, the present invention provides methods of identifying methylation patterns in genes associated with neuroinflammatory de...
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Compositions and Methods for Urinary Bladder Regeneration

The present invention provides compositions and methods for the regeneration of tissue. In particular, the present invention provides mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) for bladder regeneration....
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Live-attenuated Compositions for Bacterial Infections

The present invention relates to compositions and methods for disease treatment and prevention through administration of a live attenuated composition. In particular, the present invention provides compositions and methods for the treatment and prevention of urinary tract infection by administration...
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Compositions and Methods for Treating Conditions Associated with Neuronal Dysfunction

The present invention relates to compositions and methods for the treating and empirically investigating conditions associated with neuronal dysfunction (e.g., chronic pain, epileptic neuronal activity). In particular, the present invention provides compositions and methods for using flufenamic acid...
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Surface Independent, Surface-Modifying, Multifunctional Coatings and Applications Thereof

The invention provides surface treatments that reduce or eliminate marine biofouling of various surfaces. A surface that is to be subjected to a marine environment can be treated with a mPEG-DOPA. The treated surface is thus rendered less susceptible to fouling of the surface....
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Method for Reducing Scarring During Wound Healing Using Antisense Compounds Directed to CTGF

This invention provides a method for reducing hypertropic scarring resulting from dermal wound healing in a subject in need which comprises administering to the subject an antisense oligonucleotide which inhibits expression of connective tissue growth factor (CTGF) in an amount effective to inhibit ...
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Methods for Scar Prevention

Provided herein are compositions and methods for preventing or reducing scar formation (e.g., hypertrophic scars). For example, provided herein are methods of administrating HMG-CoA-inhibiting agents for preventing or reducing scar formation....
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Compositions and Methods for Treating Lymphoma

Provided are compositions comprising PX-478, or metabolites, analogs or derivatives thereof for treatment of lymphoma....
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Use of ECDI-fixed Cell Tolerance As a Method for Preventing Allograft Rejection

The present invention provides methods, systems, and compositions for inducing donor-specific tolerance. In particular, the present invention provides methods of administering ECDI-treated cells before, during, and/or after administration of donor transplant cells or a donor allograft in order to in...
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Methods, Compositions and Articles of Manufacture for Contributing to the Treatment of Cancers

Methods, compositions and articles of manufacture for contributing to the treatment of cancers, including solid tumors, are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ETB) to enhance the delivery and resulting efficacy of a chemotherapeutic ...
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Anticoagulant Antagonist and Hemophilia Procoagulant

A method for treating a coagulation deficient patient comprises administering an amount of polyP to the patient sufficient to reduce the PT Test value or Dilute PT Test value of the plasma of the patient....
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Minimally-invasive Measurement of Esophageal Inflammation

The methods and apparatus of the present invention allow the evaluation of inflammation of the esophagus. Measurements may be utilized, for example, to diagnose a disease of the esophagus, to monitor inflammation of the esophagus, or to access the treatment of a disease of the esophagus. In one embo...
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Fibrin Sealant

A fibrin sealant, comprises (a) thrombin, (b) fibrinogen, (c) polyP, and (d) calcium. The thrombin and the fibrinogen are separated prior to application....
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Encapsulated Materials and Methods for Encapsulating Materials

A system that incorporates teachings of the present disclosure may include, for example, an apparatus having an outer nozzle operable to discharge an outer stream of a shell solution, and an inner nozzle operable to discharge an inner stream of a core solution intermixed with a plurality of material...
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Compositions and Methods for Treating Pulmonary Hypertension

Provided herein are methods and materials for treating pulmonary hypertension (PH) in a subject. Also provided herein is a method of diagnosing whether a has PH by detecting a PH marker. A PKG pulmonary hypertension marker has been identified and may be useful in predicting PH disease progression an...
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Compositions Comprising Decitabine and Tetrahydrouridine and Uses Thereof

Compositions comprising decitabine and tetrahydrouridine for the treatment of blood disorders and hematological and solid malignancies are described....
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Functional Role for Cannabinoids in Autonomic Stability During Sleep

The present invention relates generally to pharmacological methods for the prevention or amelioration of sleep-related breathing disorders via administration of cannabimimetic agents and combinations thereof....
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Method of Treating Neurological Diseases

A method of treating neurological diseases, like Alzheimer's Disease by administering a compound that activates protein kinase C and inhibits histone deacetylases to an individual suffering from the neurological disease. The method utilizes benzolactam compounds that reduce Ass production and blocks...
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Phospholipid Micellar and Liposomal Compositions and Uses Thereof

The invention generally relates to compositions and methods for the reduction or neutralization of toxins associated with a bacterial, mycobacterial, fungal, viral, or protozoal agent. More particularly, the invention is directed to sterically stabilized phospholipid micellar and liposomal compositi...
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Modulation of Platelet Aggregation

Methods and compositions for inhibition of platelet cell aggregation are described. In particular, compositions comprising cell permeant RGT peptides, such as RGT bound to a lipid moiety are provided. Compositions may be used in the treatment and prevention of clot related diseases such as stroke an...
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Methods and Compositions for the Inhibition of Thrombus Formation

The present invention is directed to compositions comprising inhibitors of GPIb-IX-VWF binding and methods of treating or preventing thrombosis associated with sepsis or endotoxemia in a mammal....
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Anti-bacterial Compositions and Methods Including Targeting Virulence Factors of Staphylococcus Aureus

This disclosure relates to compositions and methods including for the inhibition, prevention, and/or treatment of microbial infections, including infections from such pathogens as Staphylococcus aureus....
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Method and Composition for Treating Alzheimer's Disease and Dementias of Vascular Origin

A composition and method of treating Alzheimer's disease or a dementia of vascular origin are disclosed. The composition and method utilize an endothelin antagonist as the active agent to treat Alzheimer's disease or a dementia of vascular origin in mammals, including humans....
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Compositions and Methods for Treating a Disease Mediated By Soluble Oligomeric Amyloid Beta

The present invention relates to methods for restoring fast axonal transport in a cell affected by oligomeric amyloid beta and for treating an oligomeric amyloid beta- mediated disease such as Alzheimer's disease using a Casein Kinase 2 inhibitor and, in some embodiments, a Glycogen Synthase Kinase ...
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Compositions and Methods for the Treatment of Myocardial Dysfunction Associated with Sirs Or Sepsis

Provided are compositions and methods for the treatment of myocardial dysfunction associated with SIRS or sepsis, which methods comprise the administration to a patient in need thereof of a composition comprising one or more adenosine deaminase (ADA) inhibitor and/or one or more xanthine oxidase (XO...
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Method for Detecting the Existence of Renal Calculi And/or Inflammation of the Excretory Urinary Tracts

The invention relates to methods for detecting diseases of the excretory urinary tracts. The aim of the invention is to provide a method for detecting the existence of diseases of the excretory urinary tracts, which can be carried out non-invasively, thus allowing first indications of disease, e.g. ...
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Method of Determining Sensitivity of Human Or Non-human Animal Cells to an IAP Antagonist

cFLIP serves as a biomarker for efficacy of treatment with IAP antagonists, including Smac peptidomimetics....
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X-ray Marker for Visually Comparing and for Controlling the Image Processing in Digital X-ray Recordings, in Particular for a Thorax X-ray Recording for a Patient Lying Down

The invention relates to an X-ray marker (1) that is also to be X-rayed in an X-ray recording of an organ of a patient (3) to be examined. The X-ray marker (1) has such a geometric X-ray weakening structure, so that the associated X-ray image (R) approximately shows the expected X-ray image structur...
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Device for Determining Vertebral Distances of the Spinal Column of a Patient

The invention relates to devices for determining vertebral distances of the spinal column of a patient. The devices are characterized in particular in that vertebral distances of the patient while walking in a building or outdoors can be easily detected. For this purpose, at least two marks are appl...
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Modulation of MLCK-L Expression and Uses Thereof

In various aspects and embodiments the invention provides methods and reagents for controlling gene expression, and for treating disorders and diseases. Embodiments provide methods and reagents specifically for the regulation of MLCK expression and for the use thereof in treating disorders and disea...
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Methods of Treating Diastolic Dysfunction and Related Conditions

The invention provides a method of treating diastolic dysfunction, e.g., diastolic dysfunction with preserved ejection fraction, in a subject. The method comprises administering to the subject in an amount effective to treat the diastolic dysfunction a cardiac metabolic modifier comprising a structu...
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Compositions and Methods for the Treatment of Krabbe and Other Neurodegenerative Diseases

Provided are compositions and methods for the treatment of Krabbe and other neurodegenerative diseases, including storage diseases such as GMl gangliosidosis, Niemann-Pick disease, Tay-Sachs disease, Sandhoff disease, metachromatic leukodystrophy, Canavan disease, Pelizaeus-Merzbacher disease, and s...
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Method and Composition for Potentiating an Opiate Analgesic

Composition and methods of treating pain and reducing or reversing tolerance to opiate analgesics are disclosed. The composition and method utilize an opiate analgesic and an endothelin antagonist as active agents to treat pain in mammals, including humans....
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Hdac Inhibitors and Therapeutic Methods Using the Same

Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a neurological disease, traumatic brain injury, stroke, malaria, an aut...
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Antimicrobial Therapy for Bacterial Infections

The disclosure provides compounds and methods to treat bacterial pathogenesis, and demonstrates that the S. aureus pigment is a virulence factor and potential novel target for antimicrobial therapy....
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Compositions and Methods for Inhibiting Entry of a Hepatic Virus

The present invention embraces Niemann-Pick C1-like 1 protein antagonists and agents that inhibit hepatic virus infection for use in the prevention and treatment of a hepatic virus infection....
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Materials and Methods for Making Improved Micelle Compositions

Provided are methods of treatment of many different diseases and disorders using micelle and sterically stabilized crystalline compounds of the invention....
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Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells

Solutions and suspensions comprising polymerized hemoglobin derived from human blood are disclosed. The solutions and suspensions may comprise cell culture medium, an enzyme (such as a protease), and/or a buffer. Processes of preparing the solutions and suspensions are also disclosed. The solutions ...
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Self-assembled Toroidal-spiral Particles and Manufacture and Uses Thereof

Toroidal-spiral shaped particles, their method of manufacture, and uses thereof are disclosed. The toroidal-spiral particles can contain at least one active agent, such as a drug, and provide a controlled, sustained release of the active agent....
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Methods and Compositions for Treating Brain Diseases

The present disclosure provides targeting peptides and vectors containing a sequence that encodes targeting peptides that deliver agents to the brain....
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Bioactive Sutures for the Treatment of Cancer

The present invention relates to compositions and method for the treatment of cancer using a suture or dressing providing a plurality of tumor cell antigens and/or an immunostimulatory agent to a subject in need of such treatment....
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RCA Locus Analysis to Assess Susceptibility to AMD and MPGNII

The invention relates to gene polymorphisms and genetic profiles associated with an elevated or a reduced risk of alternative complement cascade deregulation disease such as AMD and/or MPGNII. The invention provides methods and reagents for determination of risk, diagnosis and treatment of such dise...
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Prenylated Bisphosphonates As Anti-tuberculosis Agents

The invention provides methods to treat a mycobacterium infection and methods to inhibit mycobacterial polyprenyl pyrophosphate synthesis with a compound of formula I. The invention also provides novel compounds of formula I as well as salts and prodrugs thereof....
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Diagnosis and Treatment of Age-Related Macular Degeneration

The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of AMD....
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Method and Compositions for Treating and Preventing Seizures By Modulating Acid-sensing Ion Channel Activity

This invention provides novel methods and compositions for treating and preventing seizures by administration of ASIC1a receptor activating compounds. A novel method of assaying ASIC1a receptor activating compounds is included in the present invention. According to the invention applicants have demo...
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Repeated Administration of Lentiviral Vectors to Respiratory Cells

The invention provides methods for administering lentiviral vectors to the respiratory system of a patient to treat a disease....
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Ankle Prosthesis Methods

Methods of implanting an ankle prosthesis in a subject having an ankle joint in need of replacement....
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Treatment of Hepatitis C Virus Infections

This present invention provides for a new class of HCV NS3/4A protease inhibitors as additional therapeutics for hepatitis C virus. The proposed compounds, bilverdin, bilirubin, and derivatives thereof, are based on natural enzymatic products of heme metabolism that may be more stable, better tolera...
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Use of unmethylated CpG oligonucleotides for the treatment of allergy

An immuostimulatory nucleic acid containing an unmethylated CpG dinucleotide for use in a method of treating or preventing an allergy in a subject, wherein an effective dose of the immunostimulatory nucleic acid alone is to be administered to the subject....
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Vaccine, therapeutic composition and methods for treating or inhibiting francisella tularenis

The present invention is directed to compounds and methods for treating a mammal exposed to Francisella tularensis....
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Methods of Treating Pulmonary Diseases and Disorders by Modulating Calcium/Calmodulin Dependent Protein Kinase II Activity

Disclosed are methods of treating or preventing a pulmonary disease or disorder in a subject, the methods comprising administering an effective amount of an compound that inhibits Calmodulin Kinase II (CaMKII) activity, either directly or indirectly, thereby treating or preventing the pulmonary dise...
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Method for Precisely Determining the Fluorescence in a Layer System, Such As the Eye

The invention relates to a method for precisely determining the fluorescence in a layer system, such as the eye. The object of the invention is to provide a method that is as simple and requires as little effort as possible for evaluating the fluorescence in a layer system, by means of which the sum...
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Treating Cancer with Desthiazolyl Ritonavir

Treatment of cancer includes administering a compound of formula I, for example desthiazolyl ritonavir, to a subject. In particular, treatment of breast cancer is described....
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Catalytic Topoisomerase II Inhibitors

The invention provides methods and compositions useful for treating cancer, for selectively inhibiting topoisomerase II, and for inducing apoptosis....
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Ischemia/reperfusion Protection Compositions and Methods of Using.

The invention provides for ischemia/reperfusion protection compositions having one or more ketone bodies and melatonin. The invention also provides for methods of using such compositions to reduce or prevent ischemia/reperfusion injury due to blood loss, stroke or cardiopulmonary arrest or surgery....
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DNA Cytosine Deaminase Inhibitors

Cytosine deaminase inhibitors and methods for identifying inhibitors of the anti-retroviral activity of APOBEC3G are described....
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Methods of Treating HIV Patients with Anti-fibrotics

The invention relates to methods of treating patients infected with human immunodeficiency virus (HIV) with a therapeutic that has anti-fibrotic effects, for example, pirfenidone and analogs thereof....
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Decellularization and Recellularization of Organs and Tissues

The invention provides for methods and materials to decellularize an organ or portion thereof and to recellularize such a decellularized organ or portion thereof to thereby generate an organ or portion thereof....
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Methods and Materials for Isolating Isogenic Islet Cells

Compositions and methods for isolating and purifying islet cells are described. Islets obtained using such compositions and methods can be transplanted into diabetic patients....
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Methods and Systems for Treating and Preventing Cardiac Injury in Dystrophic Subjects

The present invention provides methods for treating and preventing cardiac deficiencies and injuries (e.g., cardiac injury and ventricular dilation) in dystrophic subjects using poloxamer containing compositions. In some embodiments, the polaxamers are administered to dystrophic subjects prior to ca...
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Bioresorbable Embolization Microspheres

The present disclosure is generally directed to an embolic material which is in the form of a microsphere or a plurality of microspheres. The embolic material generally comprises carboxymethyl chitosan (CCN) crosslinked with carboxymethyl cellulose (CMC). In some embodiments, the embolic material ma...
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Receptor-targeting Reagents

The present disclosure features, inter alia, receptor-targeting reagents (e.g., immunotoxic receptor-targeting reagents), which are useful in, e.g., methods of binding a receptor-targeting reagent to a cell and methods for treating a variety of disorders such as, but not limited to, cancers and infl...
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Method for Identifying Individual Viruses in a Sample

The problem of the invention consisted in identifying individual viruses in an arbitrary sample quickly, unambiguously and reliably, and with the least possible preparation-related and technology-related expenditure, without necessitating immobilization using antibodies and without requiring an indi...
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Method for Identifying Individual Viruses in a Sample

The problem of the invention consisted in identifying individual viruses in an arbitrary sample quickly, unambiguously and reliably, and with the least possible preparation-related and technology-related expenditure, without necessitating immobilization using antibodies and without requiring an indi...
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Compositions and Methods for Repair of Tissues

Biomaterials providing sustained release of growth factor for repair of tissues such as bone and cartilage are disclosed. The biomaterials comprise a proteoglycan derived from domain I of perlecan and a growth factor, and, optionally, collagen....
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Pan-Antagonists for the Androgen Receptor and Androgen Receptor Mutants Associated with Anti-Androgen Withdrawal

Disclosed herein are novel antagonists of the androgen receptor and androgen receptor mutations associated with clinical failure of currently prescribed anti-androgens and use of said antagonists in the treatment of conditions associated with inappropriate activation of the androgen receptor....
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Methods of Administering Porcine B-domainless FVIII

The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against bleeding episodes, compared to formerly available methods, or to provide more effective protection to su...
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Modified Factor VIII

Methods of treating patients with Factor VIII deficiency by administration of modified porcine factor VIII are disclosed. The particular modified porcine factor VIII is one in which most of the B domain has been removed through genetic engineering. This modified factor VIII is particularly useful fo...
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Compositions and Methods for the Treatment of Infections and Tumors.

PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD- 1 antagonists in conjunction with an antigen from the infectious agent or tumor. Thus, subje...
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Nucleoside Derivatives for Treatment of Caliciviridae Infections, Including Norovirus Infections

A method and composition for treating a host infected with a Caliciviridae virus, such as a Norovirus, comprising administering an effective treatment amount of a described modified nucleoside or a pharmaceutically acceptable salt thereof, is provided....
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Vascular Access to Extra-vascular Space

Provided are methods for accessing tissue in the vicinity of a blood vessel. Also provided are devices for use in a lumen of a patient's organ and methods for shunting interior volumes of organs....
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Systems and Methods for Preventing Mistransfusion

In some embodiments, a system and a method for preventing mistransfusion of a patient pertain to obtaining a sample of the patient's blood, obtaining a sample of blood that is about to be infused into the patient, mixing the samples together, determining whether the samples are compatible, and if th...
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Methods of Determining Renal Function using Technetium-99m Tricarbonyl-nitrilotriacetic acid

This disclosure relates to the methods of imaging the kidneys and measuring renal function using the renal tracer 99mTc(CO)3(NTA) (technetium-99m tricarbonyl-nitrilotriacetic acid). The disclosure encompasses methods of imaging the kidneys and measuring effective renal plasma flow (ERPF) in an anima...
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Compositions and Methods for Treatment Or Prevention of Post-operative Organ Or Tissue Inflammation

Compositions, methods and kits for treatment or prevention of post operative organ or tissue inflammation are provided. The compositions contain an effective amount for local delivery, of an anti-inflammatory agent, alone or in combination with other pharmacologic agents, embedded within a polymeric...
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Methods for the Treatment of Infections and Tumors

PD-I antagonists are disclosed that can be used to reduce the expression or activity of PD-I in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD-I antagonists in conjunction with an antigen from the infectious agent or tumor. Thus, subjec...
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Treatment of EBV and KHSV Infection and Associated Abnormal Cellular Proliferation

A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an effective amount of a 5-substituted uracil nucleoside or its pharmaceutically acceptable salt or prodrug...
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Treating Various Disorders with 7,8-dihydroxyflavone and Derivatives Thereof

Novel compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of 7,8-dihydroxyflavone or derivative thereof. Specifically, methods and compounds for the treatment of disorders includin...
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Methods for the Treatment of Graft-versus-host Disease

Methods are disclosed for treating or preventing graft versus host disease in a subject. The methods include selecting a subject in need of treatment for graft versus host disease; and administering to the subject a therapeutically effective amount of a TLR5 agonist such as a flagellin polypeptide, ...
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Methods for the Treatment of a Traumatic Central Nervous System Injury

Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is administered at leas...
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Methods for Preventing Oxidative Stress Injury of a Tissue By a Folate-tempol Conjugate

The present disclosure is generally related to methods of preventing oxidative stress injury induced by renal ischemia-reperfusion by a Folate-TEMPOL conjugate....
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Xenotropic Mulv-related Virus (XMRV) Compositions and Methods of Use

The invention relates to compositions and methods for analyzing and treating a disease, disorder, or condition associated with an XMRV infection....
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Small Molecule Ligand-drug Conjugates for Targeted Cancer Therapy

The present invention describes small molecule ligand-drug conjugates and methods of using the small molecule ligand-drug conjugates for targeted treatment of cancer in a patient in need thereof. Further described are methods of sterilizing circulating tumor cells and determining drug concentration ...
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Microparticles for Delivery to Cells And/or Tissues

Delivery of bioactive molecules (BAMs) to organelles, cells, tissues, or animals with high efficiency is desirable. Novel compositions for highly efficient delivery of bioactive molecules by biolistic methods are described. The novel compositions include novel microparticle cores, microparticle core...
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Mucosal Immunization

Methods and compositions for eliciting an immune response to an antigen are disclosed. In certain aspects, these methods concern eliciting an immune response in a subject by administering to the mucosa of the subject a composition comprising a virus-like particle ("VLP") and Murabutide....
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Bispecific Nanobodies As a Therapeutic for Alzheimer's Disease

The present invention provides for the treatment of Alzheimer's disease. More specifically, a recombinant bispecific antibody fragment that simultaneously blocks beta-secretase activity while also promoting alpha-secretase activity, comprising a first portion and a second portion, wherein the first ...
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Recombinant Bacterium Capable of Eliciting an Immune Response Against Enteric Pathogens

The present invention relates to a recombinant bacterium that is capable of eliciting an immune response against at least two enteric pathogens, without substantially inducing an immune response specific to the serotype of the bacterium. The invention also relates to methods of making such a bacteri...
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Methods and Compositions for Treating Or Preventing Pruritis

The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents....
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Compositions and Methods for Treating Or Preventing Radiation Injury

The invention provides compositions and methods featuring Nrf2 activators for treating or preventing radiation-associated tissue damage....
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Treatment of Chronic Inflammatory Respiratory Disorders

This invention relates, e.g., to a method for treating a subject having a chronic inflammatory respiratory disorder, comprising administering to the subject an effective amount of an inhibitor of the expression of and/or the activity of VEGF-A and/or VEGFR1 and/or VEGFR2 and/or NP1, or a combination...
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Compositions and Methods of Treating Endothelial Disorders

Compositions and methods of treating endothelial disorders, including: asthma, erectile dysfunction, pulmonary hypertension, cardiovascular disorders, and other disorders, using a synergistic combination of at least one arginase inhibitor and at least one phosphodiesterase (PDE1), (PDE2) and/or (PDE...
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Treating cancer by increasing intracellular malonyl CoA levels

A method of killing cancer cells by acute elevation of cellular malonyl Coenzyme A (Malonyl CoA) which leads to apoptosis. Elevation of malonyl CoA may be induced by inhibition of fatty acid synthase (FAS), or by other manipulation of fatty acid metabolism. Alternatively, growth of tumor cells may b...
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Compositions and Methods for Treating and Preventing Heart Tissue Degeneration and Uses Thereof

The present invention provides compositions useful for cardiac therapy comprising a cyclin-associated agent. The present invention also provides kits for use in delivering a cyclin-associated agent to cardiac cells in a subject, comprising the composition of the present invention and a catheter. The...
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Sustained Release Formulation of Melatonin

The present invention relates to low-dose formulations of melatonin, and methods of use thereof, which provide a sustained release of melatonin so as to rapidly increase plasma levels of melatonin, maintain a relatively high level (which mimics the endogenous level of a young subject) for approximat...
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Inflammation-regulating Compositions and Methods

The various embodiments provide a composition that provides local control over inflammation. The composition localizes the activities of the cytokine-neutralizing antibodies to the site of inflammation through covalent attachment to hydrophilic matrices. The various embodiments including a hydrophil...
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Antibodies and Conjugates for Modulators of Angiogenesis

We provide methods and compositions for the treatment of dysregulation of blood vessel growth by regulation of neovascularization. Embodiments accomplish this by restricting the diffusion and transport of therapeutic agents through conjugating them to polymers or polymer constructs while retaining t...
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Method of Assessing a Body Part

A method of assessing a body part includes obtaining two or more types of data through a combination of two or more of the following four imaging modalities: (1) obtaining surface topography data of the body part, (2) obtaining thermographic data of the body part, (3) obtaining range of motion data ...
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Synthetic Osteochondral Composite and Method of Fabrication Thereof

An osteochondral composite (10) including a hydrogel (24) with implanted biological cells (26) joined to a porous supportive base (12) at a mechanically-interlocked interface is disclosed. A method of fabricating the osteochondral composite (10) and a method of treating damaged or diseased articular...
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Treatment of Type 1 Diabetes Before and After Expression of Predisposition Markers

The present invention relates generally to the use of compounds, compositions, combinations, kits, and methods for the effective endocytic presentation of immunosuppressive factors for the down regulation of diabetogenic T cells for the treatment of type 1 diabetes....
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Rotator Cuff Bone-tendon Allograft

The invention provides a biomaterial and a method of selecting a biomaterial for a rotator cuff repair procedure. The biomaterial includes a bone-tendon allograft and the use of the biomaterial in rotator cuff repairs may provide immediate bone-tendon integrity and function, which may result in lowe...
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Calcium Phosphate Bodies and a Process for Making Calcium Phosphate Bodies

Among the various aspects of the present invention is a process for making calcium phosphate bodies comprising amorphous calcium phosphate, hydroxyapatite or calcium triphosphate, the bodies themselves and the use of such bodies in any of a variety of applications....
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Bacillus Based Delivery System and Methods of Use

Herein a Bacillus exosporium antigen delivery (BEAD) system that provides a means to introduce recombinant proteins or small molecules into the exosporium of members of the B. cereus family of bacteria, i.e. B. anthracis, B. cereus, and B. thuringiensis, is disclosed. The system results in the surfa...
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High-throughput and Non-invasive Method to Vitrify Porcine Embryos

The present invention provides a practical, non-invasive, and efficient method for cryopreservation of an in-vitro-produced porcine embryo. The inventive method treats the IVP (such as IVF- or NT-derived) embryo at the one-cell or cleavage stage prior to compaction with high osmolality followed by h...
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Methods for Ameliorating Adverse Effects Associated with Transfusion of Aged Red Blood Cells

The present invention provides, inter alia, methods for ameliorating an adverse effect in a patient caused by an acute transfusion into the patient of a composition containing aged red blood cells using an iron chelator. Apparatuses and kits for ameliorating such adverse effects are also provided....
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Modulation of Phospholipase D for the Treatment of Neurodegenerative Disorders

The present invention relates to methods of treating neurodegenerative diseases comprising administering, to a subject in need of such treatment, one or more agent that inhibits or reduces the action, including the catalytic activity, of an enzyme of the phospholipase D family, such as phospholipase...
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Antimicrobial Compositions Containing Low Concentrations of Botanicals

The present invention relates to a preservative or antimicrobial compositions with broad spectrum antimicrobial activity comprising low concentrations of essential oil (and/or one or more component thereof) and a botanical extract in synergistic combination with a fruit acid and alkanediol, and opti...
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Polyamine Inhibitors for the Treatment and Prevention of Parkinson's Disease

Disclosed herein are methods for treating a disease involving a-synucleic aggregation using (1) a compound which reduces the amount of polyamines in an amount effective to reduce a-synucleic aggregation; (2) a compound which inhibits polyamine synthesis in an amount effective to reduce a-synucleic a...
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Shh Regulation and Methods Thereof

The invention provides for methods of upregulating endogenous GDNF by inhibiting Shh signaling. The invention further provides a method for increasing the production of cholinergic neurons and dopamine neurons by subventricular zone (SVZ) neurogenesis in a subject. The invention further provides met...
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Treatment of Diseases with Altered Smooth Muscle Contractility

The present invention provides, inter alia, methods and compositions for treating or ameliorating the effects of a disease characterized by altered smooth muscle contractility, such as e.g., asthma....
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Synergistic Transcription Modules and Uses Thereof

The invention provides for methods for treating nervous system cancers in a subject. The invention further provides methods for treating nervous system tumor cell invasion, migration, proliferation, and angiogenesis associated with nervous system tumors....
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Methods of Diagnosing, Preventing and Treating Bone Mass Diseases

The present invention provides methods and therapeutic agents for lowering or increasing serum serotonin levels in a patient in order to increase or decrease bone mass, respectively. In preferred embodiments, the patient is known to have, or to be at risk for, a low bone mass disease such as osteopo...
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Compositions and Methods of Treating Chronic Pain By Administering Propofol Derivatives

Compositions and methods for managing or treating chronic pain are provided. More particularly, methods are provided for managing or treating chronic pain by administering to a patient in need thereof an effective amount of propofol or a propofol derivative having limited anesthetic properties. Meth...
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Regeneration of endogenous myocardial tissue by induction of neovascularization

This invention provides a method of treating a disorder of a subject's heart involving loss of cardiomyocytes which comprises administering to the subject an amount of an agent effective to cause cardiomyocyte proliferation within the subject's heart so as to thereby treat the disorder. This inventi...
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Coronary Sinus Cannula with Left Ventricle Lead and Pressure Tent

Techniques for biventricular pacing include a rigid shaped stylet approximating curves of a coronary sinus and branch vein. Some techniques include a parasternal coronary sinus cannula comprising an outer sheath and an obturator. The obturator is removeably disposed inside the outer sheath from a de...
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Methods for Assessing the Immune System in a Patient

Methods of determining the onset or susceptibility of an immunological disease are provided herein. Also provided are immunoassay techniques for carrying out such methods....
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Compositions and Methods for Wound Treatment

Provided herein are compositions, methods, systems, and kits for wound healing. As shown herein, CCN2/CTGF stimulated mesenchymal progenitor cells can form aSMA- fibroblasts. Further, TGF was shown to stimulate further differentiation of aSMA- fibroblasts to myofibroblasts associated with fibrosis. ...
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Treatment of Ophthalmic Conditions with Fluorenone Derivatives

Provided are compositions and methods for treatment of ophthalmic conditions, such as retinal detachment and age-related macular degeneration. Various fluorenone derivatives described herein can stimulate fluid removal from the subretinal space and down-regulate reactive gliosis. Administration of c...
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Methods and Compositions for Treating T-cell Leukemia

The present invention relates to compositions and methods that may be used to diagnose and treat cancer, particularly T-cell leukemia. According to one preferred embodiment of the present invention, methods are provided for determining whether reducing or blocking NOTCH-1 activation will be effectiv...
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Compounds and Methods for Treating and Preventing Exercise-induced Cardiac Arrhythmias

The present invention provides a method for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject, a method for treating or preventing exercise-induced cardiac arrhythmia in a subject, and a method for preventing exerciseinduced sudden cardiac death in a subject. Also pr...
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Compounds and Methods for Inhibiting Serotonin Synthesis

Compounds having the structures below that are TPH1 inhibitors are provided: The compounds are useful for lowering serum serotonin levels in a patient in need thereof, e.g., to increase bone mass. In preferred embodiments, the patient is known to have, or to be at risk for, a low bone mass disease s...
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Rage Regulates Rock Activity in Cardiovascular Disease

A method is provided for treating a RAGE-related disorder in a subject afflicted therewith comprising administering to the subject a therapeutically effective amount of an antagonist of rho-associated protein kinase 1 (ROCK1) so as to thereby treat the RAGE-related disorder. A method is also provide...
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Turkey Viral Hepatitis Virus and Uses Thereof

The invention is directed to a isolated a Turkey Viral Hepatitis picornavirus-like viruses associated with Turkey viral hepatitis, and isolated nucleic acids sequences and polypeptides thereof. The invention also relates to antibodies against antigens from Turkey Viral Hepatitis picornavirus-like vi...
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Use of a melanoma differentiation associated gene (mda 7) for reversing a cancerous phenotype

This invention provides a method for reversing the cancerous phenotype of a cancer cell by introducing a nucleic acid having the melanoma differentiation associated gene (mda-7) into the cell under conditions that permit the expression of the gene so as to thereby reverse the cancerous phenotype of ...
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Ngal-binding Siderophores and Use Thereof to Treat Iron Deficiency and Iron Overload

The invention provides compositions comprising a lipocalin, such as NGAL, and a mammalian siderophore that are useful as iron chelators and iron donors. The invention also provides mammalian siderophore compounds of Formula (I): The invention further provides, methods of treatment and methods of dia...
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Human Notch3 Based Fusion Proteins As Decoy Inhibitors of Notch3 Signaling

This invention provides a fusion protein comprising a signal peptide, EGF repeats 1-X of the extracellular domain of human Notch3 receptor protein wherein X is any integer from 12 to 34, and an Fc portion of an antibody bound thereto. This invention also provides a method for treating a subject havi...
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Di- und Triphosphat-Prodrugs, insbesondere Nukleosiddi- und -Triphosphat-Prodrugs

The invention relates to a propharmaceuticals useful compounds, pharmaceutical compositions produced therefrom, and drug and pharmaceutical dosage forms and a process for preparing the compounds of the invention. The invention provides bioreversible masked nucleoside diphosphates (NDP) and triphosph...
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Novel ansamitocin derivatives

This invention relates to the field of biologically active compounds and specifically to novel ansamitocin derivatives, pharmaceutical compositions comprising these novel ansamitocin derivatives, methods for the production of the ansamitocin derivatives of the general formula (I): and their use for ...
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Novel Ansamitocin Derivatives

Provided are among other things ansamitocin derivatives, pharmaceutical compositions comprising these novel ansamitocin derivatives, methods for the production of the ansamitocin derivatives and their use for the treatment of cancer....
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Treatment and Prophylaxis of Epilepsy and Febrile Seizures

Provided are methods for treatment and prophylaxis of convulsive disorders and seizures, such as epilepsy and febrile seizures, by modulating TRPVl channel activation....
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Diagnosing, Prognosing, and Early Detection of Cancers By Dna Methylation Profiling

A method of employing DNA methylation analysis for the diagnosis, prognosis, and prediction of cancer....
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Compositions and Methods for Cardiac Tissue Repair

The invention features compositions comprising agents having cardiac protective activity isolated from epicardial progenitor cells and derivatives thereof, and methods for the use of such compositions....
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Compositions and Methods for Tissue Repair

The invention features compositions comprising mesenchymal stem cells or multipotent stromal cells, agents secreted by such cells in culture, and methods featuring such cells for the repair or regeneration of a damaged tissue or organ. The present invention is based, at least in part, on the discove...
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Ribonuclease and Thiazolidinedione Compounds and their Use in Methods to Treat Cancer

The present invention relates to methods and kits for the treatment of cancer. A novel drug combination comprising a ribonuclease compound and a thiazolidinedione compound has been identified as producing a synergistic cytotoxicity effect in cancer cells. Methods and kits pertaining to the co-admini...
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Ccl18 and Ccl3 Methods and Compositions for Detecting and Treating Cancer

The invention relates to methods of treating cancer by administering one or more chemokines that are downregulated in cancerous cells. More specifically, the invention provides methods for treating or preventing cancers such as malignant melanoma by administering a chemokine such as CCL18 and/or CCL...
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Prosthetic Lung

A prosthetic lung for receipt by a lung space of a patient includes a mass exchange apparatus for use in blood/air mass exchange, an air sac and an air vessel. The mass exchange includes plural blood flow conduits for defining blood flow and a plural air flow conduits for defining air flow. The plur...
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Androgen Receptor Related Methods for Treating Bladder Cancer

Disclosed are compositions and methods for treating bladder cancer....
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Methods for the Treatment Or Prevention of Hemorrhagic Conditions

The present invention relates to a method for treatment or prevention of a hemorrhagic condition in a patient by administering plasminogen activator inhibitor-1 ("PAI-1") and/or an inhibitor of deubiquitinating enzyme CYLD ("CYLD") to a patient. Pharmaceutical compositions that include one or both o...
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Protecting and Repairing Cartilage and Musculoskeletal Soft Tissues

Provided herein are compositions and methods related to promoting protection or repair of articular cartilage and/or musculoskeletal soft tissue by contacting the cartilage, tissues or cellular components thereof with a parathyroid hormone/parathyroid hormone-related protein (PTH/PTHrP) receptor ago...
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Targeting of Histone Deacetylase 2 and Protein Kinase Ck2 for Treatment of Inflammatory Diseases

Methods for the treatment or prevention of diseases which are caused by the degradation of histone deacetylase 2 (HDAC2) in cells are described. The diseases which may be treated by the methods of the invention include chronic obstructive pulmonary disease (COPD) and asthma. The invention provides m...
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Methods and Compositions Related to Aglycosidic Esculentoside A

Disclosed are compositions related to water soluble selective COX-2 inhibitors and methods of using the inhibitors (including h-EsA and derivatives thereof.)...
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Methods and Compositions for the Treatment Or Prevention of Pathological Cardiac Remodeling and Heart Failure

The invention relates to methods of treating or preventing pathological cardiac remodeling and/or preventing heart failure. These methods include the administration of a PDEl inhibitor to a patient under conditions effective to treat or prevent pathological cardiac remodeling, and therefore heart fa...
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Methods and Compositions for Treating Inflammatory Conditions

The present invention is directed to methods of treating an inflammatory condition in a patient. This method includes providing a therapeutic agent that is a vascular endothelial growth factor receptor-3 (VEGFR-3) agonist or a nucleic acid molecule encoding a VEGFR-3 agonist. The present invention i...
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Molecular Targets for Treatment of Inflammation

Molecular targets and methods for treating inflammatory disorders are described. The expression and/or functionality of molecular targets RelB or SIRT1 is modified in order to treat inflammatory disorders. The expression of RelB or SIRT1 may be increased, or the activity of RelB or SIRT1 may be incr...
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Use of Electrophilic Compounds for Inducing Platelet Production Or Maintaining Platelet Function

The present invention is directed to a method of inducing platelet production that includes contacting a megakaryocyte with an electrophilic compound under conditions effective to induce platelet production by the contacting megakaryocyte. Methods of treating a patient for low platelet levels, incre...
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Parathyroid Hormone Treatment for Enhanced Allograft and Tissue-engineered Reconstruction of Bone Defects

Methods of improving an outcome of a bone allograft procedure in a subject suffering from a massive bone defect are described, including providing a bone allograft to the subject and intermittently providing said subject with parathyroid hormone (PTH); where the PTH is provided in an amount effectiv...
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Methods and Compositions Related to Tr4 Ligand

Disclosed are compositions and methods related to TR4 and aging....
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Use of Biliverdin Reductase (bvr) and Bvr Peptide Fragments to Treat Coronary Disorders

The present invention relates to methods and compositions for treating coronary disorders and preventing cardiac cell death that involve the use of biliverdin reductase ("BVR") or BVR peptides to stabilize the expression and activity of intracellular HO-2 in cardiac cells. The present invention also...
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Methods of Modifying P53 Acetylation and Treating Cancer Using Avra

The present invention relates to methods and compositions for the treatment of cancer. The methods and compositions involve the use of the Salmonella effector protein AvrA, as well as variants or fragments thereof, or encoding nucleic acids. The AvrA effector protein is demonstrated to enhance p53 a...
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Aberration Control By Corneal Collagen Crosslinking Combined with Beam-shaping Technique

Corneal collagen crosslinking is used to alter a characteristic of the cornea, such as thickness or refractive index, to correct wavefront aberrations, including higher-order aberrations. A scanning laser or the like is used to perform the corneal collagen crosslinking by locally altering the optica...
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Methods of Diagnosing and Treating Fibrosis

The present invention is directed to methods of diagnosing and treating a fibrotic condition in a mammalian subject. These methods involve measuring the levels of trimethylation at lysine residue 27 of histone-3 and/or measuring the expression levels of EZH2 or YY-1. Agents useful for treating fibro...
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Compositions that inhibit proliferation of cancer cells

The present invention relates to compositions and methods for reducing the proliferation of cancer cells through targeted interactions with integrin....
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Fibroblast Growth Factor (fgf) Analogs and Uses Thereof

The invention relates to novel peptide comprising FGF-P and methods of use thereof....
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Method for Modifying the Refractive Index of Ocular Tissues

A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) di...
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Methods of Treating Inflammatory Intestinal Disease and Managing Symptoms Thereof

Methods and products are disclosed for treating an inflammatory intestinal disease in a mammalian subject in need thereof, or preventing or reducing a symptom of inflammatory intestinal disease. These method include administering to the subject a therapeutically effective dose of (i) an isolated Avr...
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Method of Generating ?0 Cells

Described is a method of the generation of ? DEG cells using a mitochondrial targeted restriction endonuclease. This method comprises (a) transfecting cells with an expression vector containing a gene encoding a fusion protein comprising a mitochondrial targeting sequence (MTS) and a restriction end...
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Method and Kit for the Ex Vivo Evaluation of the Response of a Tumor to Conditions to Be Tested

The invention concerns a method and kit for the ex vivo evaluation of the response of a tumor to conditions to be tested, in particular a tumor treatment regime, in an isolated tumor sample. The diagnostic method is suitable for the use in medicine and in pharmacy, in particular for the pretherapeut...
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Cancer Treatment with Gama-secretase Inhibitors

Provided are methods for treating cancer in a patient, comprising administering to a patient in need thereof a therapeutically effective regimen, the regimen comprising administering a gamma-secretase inhibitor, wherein the regimen results in a reduction in the cancer cell population in the patient....
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Immunotherapy for Contact Dermatitis Using Co-signal Regulation

Compounds, compositions and methods for immunotherapy in contact dermatitis. Compounds and compositions (e.g. monoclonal antibodies) that stimulate the LAIR-1 expression pathway in LAIR-1 expressing immune cells and are useful for preventing or treating contact dermatitis are provided....
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Inhibitors of Hedgehog Signaling Pathways, Compositions and Uses Related Thereto

The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction pathway, e.g., which involve the use of a steroidal alkaloid or other small molecule....
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Compositions and Methods for Treating Hepatic Neoplasia

The present invention provides compositions and methods featuring miR-26 microRNA polynucleotides for the diagnosis, treatment or prevention of hepatic neoplasia....
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Peroral transgastric endoscopic techniques

Methods and apparatus for accessing the peritoneal cavity and for ligation of fallopian tubes. A representative method includes using an endoscope to orally access a gastric wall. The gastric wall is punctured to provide access to a peritoneal cavity. The endoscope is advanced into the peritoneal ca...
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Methods of Promoting Muscle Growth

The present invention relates to use of the interaction of myostatin with the activin type II receptors, and more specifically to use of soluble ACVR2 to increase muscle growth in a subject. As such, methods of increasing muscle mass in a subject are provided. In addition, methods of ameliorating th...
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Compositions and Methods for Enhancing Antigen-specific Immune Responses

Methods for treating or preventing recurrence of hyper proliferating diseases, e.g., cancer, are described. A method may comprise priming a mammal by administering to the mammal an effective amount of a nucleic acid composition encoding an antigen or a biologically active homo log thereof and boosti...
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Compositions and Methods for Inactivation of Pathogens At Genital Tract Surfaces

The present disclosure includes compositions and methods of inactivating pathogens of a genital tract of a female. The compositions include L-lactic acid substantially free of D-lactic acid. In particular, an intravaginal ring for sustained release of L-lactic acid out of a reservoir containing mult...
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Target for Therapy of Cognitive Impairment

PROBLEM TO BE SOLVED: To provide a method of identifying a gene associated with a desired behavior in a mammal. ; SOLUTION: The method of identifying a gene associated with the desired behavior in a mammal comprises the steps of: (a) providing a test population of mammals having the desired behavior...
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Methods for Protecting the Skin from Radiation Insults

The present invention relates to methods and compositions for the protection of skin and mucous membranes from undesirable side effects of ionizing radiation in a patient undergoing ionizing radiation therapy. In particular, the application describes compositions and methods comprising the topical u...
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Cancer Immunotherapy with a Viral Antigen-defined, Immunomodulator-secreting Cell Vaccine

A human cell line, which lacks major histocompatibility class I (MHC-I) antigens and major histocompatibility class II (MHC-II) antigens and which has been modified to comprise and express (i) a nucleotide sequence encoding an immunomodulator and (ii) a nucleotide sequence encoding a viral antigen, ...
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Photoinitiated Tissue Filler

Visible light-activated polymer cosmetic filler preparations useful in a variety of applications are provided. In some embodiments, the photo-activated polymer composition comprises a conventional polymeric material, such as HA, together with a modified, cross-linkable polymer, such as PEG or PEODA,...
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Gold (iii) Complexes with Oligopeptides Functionalized with Sulfur Donors and Use Thereof As Antitumor Agents

The invention concerns Au(III) complexes of the type [AuIIIX2(Pdtc)] (X = halogen, pseudo-halogen; pdtc = peptide-/esterified peptidedithiocarbamato) which are able to both maintain the antitumor properties and the lack of nephrotoxic side-effects of the previously reported Au(lll)-dithiocarbamato c...
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Methods of Treating Cancer with Cd11b Antibodies

Methods and compositions for treating cancer with CD11b antibodies are disclosed. The antibodies may be WT.5 antibodies or compete with WT.5 antibodies, and induce apoptosis in SKOV, MDAH-2774, or BxPC-3 cells...
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Erythrocyte Atp-release Modulators

Erythrocyte ATP-release modulators and composition and methods for their use to potentiate serum glucose clearance and vasodilation; methods for prophylactic or palliative therapy of glucose processing or vascular disorders; processes for preparing the modulators and compositions comprising them; an...
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Monophosphorylated Lipid a Derivatives

The present invention provides for monophosphorylated lipid A derivatives and carbohydrate derivatives that are useful as agents in the treatment of diseases and conditions, including cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I-IV. In addition...
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Light Therapy Treatment

An exemplary method includes selecting at least one light source configured to generate light at a particular wavelength and applying the light to tissue following an ischemic event. Applying the light to the tissue inhibits cytochrome c oxidase activity. Another exemplary method includes selecting ...
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Medicament for Treating Problems Relating to Fertility and Pregnancy, and Autoimmune Diseases, and for Inducing an Immunological Tolerance in Transplant Patients, and Method for Producing Said Medicam

A medicament for treating pregnancy disorders or for inducing an immunological tolerance in patients with autoimmune diseases or transplantation processes, contains at least one each of a) a precursor hCG beta subunit of the human choriongonadotropine (hCG) selected from hCG beta6 according to SEQ I...
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Cell culture medium and method for culturing stem cells and progenitor cells

The invention relates to a stem cell culture medium that is deficient in both glucose and inositol. As expected most cells die rapidly as in media deficient in both glucose and inositol. However, in particular somatic stem cells and germ line stem cells are surprisingly capable of survival and growt...
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Use of the Opposite Cell Differentiation Program (ocdp) for the Treatment of Degenerated Organs in the Pathological State

The present invention relates to a method for the treatment of organs which are degenerative and /or in the pathological state by means of the use of cells, which are phenotypically stably differentiating or differentiated but not necessarily ultimately predetermined with respect to development, fro...
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Pharmaceutical Agent for the Treatment of Fertility and Gestation Disorders, Immunological Diseases, and Transplantation for Use in Veterinary Medicine, Particularly in Horses, and Methods for the Pro

The invention relates to pharmaceutical agents for the treatment of fertility and pregnancy disorders, and immunological diseases (autoimmune diseases) and transplantation, and a method for the production thereof for use in veterinary medicine, particularly in horses. According to the invention, a p...
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Aurora Kinase Inhibitors Compounds.

The present invention relates to novel compounds of formula (I) that inhibit cell proliferation, in particular by inhibiting selectively Aurora A kinase activity and to their use in medicine, in particular for treating, ameliorating or preventing hyperproliferative diseases. The invention further re...
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New Rac1 Inhibitors As Potential Pharmacological Agents for Heart Failure Treatment

The present invention finds application in the field of medicine and, in particular, to new compounds particularly active in inhibiting Rac1 member of the Rho family. Pharmaceutical preparations containing them useful for the treatment and/or prevention of heart failure are disclosed as well....
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Treatment and Diagnostic Methods for Fibrosis Related Disorders

The present invention relates to the ability of SAP to suppress fibrocytes. It also relates to the ability of IL-12, laminin-1, cross-linked IgG and IgG aggregates to suppress fibrocytes. Methods and compositions for suppressing fibrocytes using these proteins are provided. These methods are useful ...
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Water-soluble Carbon Nanotube Compositions for Drug Delivery and Medicinal Applications

Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for mak...
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Water-soluble Carbon Nanotube Compositions for Drug Delivery and Medical Applications

Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for mak...
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System and method for intra-body communication

A method comprising generating a mechanical signal in a mammal, the mechanical signal having a frequency no more than 50,000 Hz, transmitting the mechanical signal through the musculoskeletal system in the mammal, and sensing the mechanical signal from the musculoskeletal system. A method of trigger...
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Method for Measuring Disease Probability

Methods comprising providing a tissue sample, providing a first imaging device comprising a white light imaging device; providing a second imaging device comprising at least one imaging device selected from the group consisting of: a fluorescent imaging device, a narrowband reflectance imaging devic...
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A Decellularization Method for Scaffoldless Tissue Engineered Articular Cartilage Or Native Cartilage Tissue

Methods for fabricating a tissue-engineered construct comppsing: providing a tissue-engineered construct, wherein the tissue-engineered construct is derived from a xenogenic source; and decellularizing the tissue-engineered construct....
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Scaffoldless Constructs for Tissue Engineering of Articular Cartilage

A process for culturing chondrocytes to form constructs which contain higher percentages of cells that retain the chondrocytic phenotype are disclosed. The tissue engineered constructs may be formed into neocartilage-containing compositions for a variety of...
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Unique Dual-action Therapeutics

A new family of therapeutics which provides a controlled-release delivery platform for non-steroidal anti-inflammatory agents on an ester or an ester-carbonate backbone is disclosed herein. These agents are reversible inhibitors of acetylcholinesterase and are thus useful for clinical conditions ben...
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Treatment of Disorders Associated with G Protein-coupled Receptor 35 (gpr35)

Compounds are provided having agonistic activity against G protein- coupled receptor 35 (GPR35). The compounds are useful for providing antinociception, providing neuroprotection in case of stroke or ischemia, or treating gastric inflammation....
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Leptin Antagonist and Methods of Use

This invention provides compounds that are true antagonists of the leptin receptor, in the presence and the absence of native leptin or another leptin receptor binder. These compounds may be used to inhibit leptin receptor activity, promote growth arrest or death of leptin receptor-positive cancer c...
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Angiocidin Inhibition of Tumor Cell Growth

Methods are presented for the therapeutic administration of angiocidin in the treatment of cancers such as glioma, breast cancer, and leukemia. Methods are also presented for inducing growth arrest and/or apoptosis of tumor cells, as well as inducing differentiation of tumor cells to inhibit tumorig...
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Treatment of proliferative disorders with amino-substituted (E)-2,6- dialkoxystyryl 4-substituted benzylsulfones

Methods of treating cancer using compounds according to Formula (I) are disclosed herein, wherein X, X1, X2, Ra, R1, R2, R3, R4, R5, R6, R7, g, M, y, a, b, d, e, V, W, Z and Q are as defined herein....
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Leptin Agonist and Methods of Use

Peptides are provided having leptin receptor agonist activity. The peptides are useful for treating obesity, insulin resistance, lipodystrophy and hypothalamic amenorrhea, anorexia-related infertility, among other diseases and conditions related to leptin deficiency and/or leptin resistance....
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Blood Monocyte Cd163 Expression As a Biomarker in Hiv-1 Infection and Neuroaids

The invention provides a method for detecting CD163+/CD16+ cell population in peripheral blood mononuclear cells in a biological sample from a subject infected with HIV-1 which comprises contacting the biological sample with an anti-CD163 antibody, so that levels of CD163+/CD16+ peripheral blood mon...
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Engineered Dendritic Cells and Uses for the Treatment of Cancer

This invention provides the field of therapeutics. Most specifically present invention provides methods of generating in vitro engineered dendritic cells conditionally expressing interleukin-12 (IL- 12) under the control of a gene expression modulation system in the presence of activating ligand and...
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Virus Derived Antimicrobial Peptides

Described herein are peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides, designated LBU, WLBU and WR, are analogs of the Lentivirus Lytic Peptide 1 (LLP1) amino acid sequence. The antimicrobial peptides are monomers or multimers of peptides referred to as the...
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Nitrated-fatty Acids Modulation of Type Ii Diabetes

Nitro oleic acid and related metabolites are agonists of PPAR-?. Surprisingly, nitro oleic acid is a more potent agonist of PPAR-?, relative to nitro linoleic acid. Thus, nitro oleic acid and its metabolites, as well as their pharmaceutically acceptable salts and prodrug forms, are candidate therape...
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Methods for Heat Shock Protein Dependent Cancer Treatment

The present invention provides a method of treating an Hsp70 dependent cancer, including: providing at least one Hsp70 dependent cancer cell; contacting the at least one cell with a sub-effective concentration of a dihydropyrimidinone compound; and contacting the at least one cell with a sub-effecti...
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Surfactant-based Antimicrobial Solution for Inhalation

A surfactant can be added, safely and effectively, to a drug solution containing any antimicrobial agent, such as an antibiotic like tobramycin, that is suitable for administration to the lungs via inhalation. Thus, when an aerosolized drug solution includes surfactant, Marangoni flows cause the dru...
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Radioprotective Agents

Provided herein are methods, for reducing, preventing, mitigating and treating damage caused by radiation. The methods comprise delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation or to mitigate a...
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Administration of an Adsorbent Polymer for Treatment of Systemic Inflammation

The invention provides a method of ameliorating systemic inflammation in a patient involving administering to the patient a therapeutically effective dose of composition including polystyrene divinyl benzene copolymer and a polyvinyl pyrrolidone polymer. More particularly, the method relates to usin...
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Methods and Compositions for Regulating Th2 and Th17 Responses

Methods are provided for treating diseases, such as asthma, inflammatory bowel disease, autoimmune disease and cancers in which IL-6 production by dendritic cells is elevated. Dendritic cell c-Kit signaling is implicated herein in the production of IL-6 and an elevated TH17 response, such as an elev...
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Lymph Nodes As a Site for Regeneration

Methods of transplanting cells, such as hepatocytes, are presented herein. Such methods are useful for treating liver disease as well as other disorders....
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Vocal Cord Augmentation Utilizing Muscle-Derived Progenitor Compositions, and Treatments Thereof

The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment vocal cord tissue following introduction (e.g. via injection, transplantation, or implantation) into the vocal cords. Also provided are method...
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Methods of Treating Disorders Associated with Protein Polymerization

The present invention relates to methods of treatment of clinical disorders associated with protein polymerization comprising administering, to a subject, an effective amount of carbamazepine, oxcarbazepine or another carbamazepine-like compound. It is based, at least in part, on the discovery that,...
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Fatty Acids As Anti-inflammatory Agents

Compounds of formula I and their metabolites are potent mediators of an inflammatory response: (I) where a, b, c, d, e, f, V, W, X, Y, Ra, Ra', Rb, Rb', Rc, and Rc'are defined herein. In particular, the compounds of the invention are candidate therapeutics for treating inflammatory conditions....
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Removal of Oxygen from Biological Fluids

A system for reducing the concentration of oxygen in a fluid including red blood cells includes a housing, a plurality of hollow tubes extending within the housing and adapted for flow of the fluid therethrough, wherein each tube includes an inlet and an outlet, and a carrier system that reduces the...
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Estrogen Antagonists As Treatments for Sclerosing Disorders

The present invention relates to methods and compositions for treating a subject suffering from a sclerosing disorder, comprising administering, to the subject, an effective amount of an estrogen receptor antagonist ("ERANT"), wherein said ERANT has essentially no estrogen receptor agonist activity ...
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Use of Targeted Nitroxide Agents in Bone Healing

Provided herein are compositions and related methods useful for accelerating bone healing and growth. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity....
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Blood Vessel Segmentation with Three-dimensional Spectral Domain Optical Coherence Tomography

In the context of the early detection and monitoring of eye diseases, such as glaucoma and diabetic retinopathy, the use of optical coherence tomography presents the difficulty, with respect to blood vessel segmentation, of weak visibility of vessel pattern in the OCT fundus image. To address this p...
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Constitutive Androstane Receptor (car) As a Therapeutic Target for Obesity and Type Two Diabetes

The invention provides a method of controlling obesity or type two diabetes in a human. In accordance with the inventive method, the constitutive androstane receptor (CAR) is agonized within the human, which effectively controls obesity or type two diabetes....
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Anti-hmg Monoclonal Antibodies and Compositions Containing the Same

Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMG A box, and an antibody preparation that specifically binds to a vertebr...
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Stable Lipid-comprising Drug Delivery Complexes and Methods for their Production

Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon...
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Urinary Biomarkers for Predicting Long-term Dialysis

This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine ...
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Methods of Treating Disorders Associated with Protein Aggregation

The present invention relates to methods of treatment of clinical disorders associated with protein aggregation comprising administering, to a subject, an effective amount of an anti- protein aggregate ("APA") compound selected from the group consisting of pimozide, fluphenazine (e.g., fluphenazine ...
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Compositions and Methods for Detecting Cancer

The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and diagnosing cancer in an individual; methods of identifying individuals at risk of developing a cancer; and meth...
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Use of Endostatin Peptides for the Treatment of Fibrosis

C-terminal endostatin polypeptides are disclosed herein. These polypeptides include or consist of at least at least 40 consecutive amino acids of the amino acid sequence set forth as amino acids 133-180 of SEQ ID NO: 2 or SEQ ID NO: 13 with at most 5 amino acid substitutions, wherein the polypeptide...
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Matricryptic Ecm Peptides for Tissue Reconstruction

Chemoattractant polypeptide compounds for progenitor cells and compositions and drug products comprising the compounds are provided herein. Methods for attracting progenitor cells to a location in or on a patient also are provided along with methods of growing and repairing bone....
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Devices, Systems and Methods for Cell Modification

A method of modifying cells includes removing fluid including cells from a patient, contacting the removed fluid from the patient with at least one surface upon which at least one agent to interact at least one cell receptor is immobilized to modify cells in the fluid, and returning the fluid to the...
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Non-invasive Method to Treat Urological and Gastrointestinal Disorders

Provided herein are methods and devices useful for inhibiting or treating urological conditions, such as overactive bladder (OAB) symptoms including bladder overactivity, urinary frequency, urinary urgency, urinary incontinence, interstitial cystitis (IC), urinary retention, and pelvic pain; gastroi...
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Method for Treating Alcoholic Hepatitis

Disclosed is a method for treating acute alcoholic hepatitis in a subject. The method comprises the step of administering to the subject an effective amount of an ester of an alpha-ketoalkanoic acid or an amide of an alpha-ketoalkanoic acid....
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Wortmannin Analogs and Method of Using Same

Wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment of cancer and tumour formation in a subject are described herein. The wortmannin analogs have utility in the treatment of cancer, in particular, lung cancer....
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Bone Substitute Compositions, Methods of Preparation and Clinical Applications

The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium phosphate, acidic calcium salt, basic calcium salt, sodium hydrogen phosphate and porogen. The compositions furth...
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Functional Near-infrared Spectroscopy As a Monitor for Depth of Anesthesia

Disclosed are methods and devices for measuring a state of anesthesia in a noninvasive manner. Optical techniques may be used to measure changes in a functional near-infrared (fNIR) signal, where the fNIR signal is received in response to directing wavelengths of light in a near-infrared range on a ...
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Tissue Joining Device and Instrument for Enabling Use of a Tissue Joining Device

A tissue joining device and a surgical instrument for employing the tissue joining device are provided. The tissue joining device may be designed such that a first member may be inserted into a second member in discrete increments so that two lumen structures can properly be combined....
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Local Delivery System for the Chemotherapeutic Drug Paclitaxel

The present invention provides methods for producing a semi-degradable polymeric composite drug delivery device for localized delivery of chemotherapeutic agents to be used in conjunction with total vertebral body replacement surgery that requires placement of a vertebral replacement cage for the tr...
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Dual Inhibitors of HIV-1 GP-120 Interactions

Compounds, which inhibit the binding of gp120 to CD4 as well as 17b and methods for their use in inhibiting the HIV fusion process, are provided....
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Methods and Devices for Treating Surfaces with Surface Plasma

Methods and devices for treating surfaces of objects using a non-thermal plasma are disclosed herein. The non-thermal plasma is generated through the use of an apparatus configured to generate a non-thermal plasma on its surface. The apparatus is comprised of a substrate that contains one or more el...
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Articles and Methods for Repairing Damaged Nervous Tissue

The invention concerns substrates comprising a biocompatible gel and at least one of a plurality of cells, said cells being capable of producing at least one therapeutic agent. Other aspects of the invention concern methods of making such substrates and methods of repairing and regenerating damaged ...
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Physical Therapy Systems and Methods

The invention is directed to a physical therapy system including a glove with a set of acoustic sensors and a positive feedback system and method for teaching finger extension. The system may also include a pair of gloves with a set of acoustic sensors and a positive feedback system to teach clappin...
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Tricyclic Compounds Having Cytostatic And/or Cytotoxic Activity and Methods of Use Thereof

The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase and/or dihydroorotate dehydrogenase inhibitory activity, which are useful as anti-angiogenic and anti-tum...
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Methods for treating cancer by inhibiting mitosis using pyrrolo[2,3-d]pyrimidines

A compound having the following formula: wherein X is selected from the group consisting of a C1 to C6 alkyl group, a heteroalkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, an arylalkyl group, and a heteroarylalkyl group; wherein R 1 is selecte...
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Antiretroviral Drug Formulations for Treatment of Children Exposed to Hiv/aids

The present disclosure provides fast disintegrating formulations for the treatment of human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) in patients such as neonatal, perinatal and pediatric children. Neonatal and perinatal formulations provide for the prevention or re...
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Cornea Reshaping

A corneal reshaping kit may include a mold defining a concavity that is sized and shaped for receiving an outer corneal surface, such that a corneal surface pressed against the concavity will adopt a convex shape complementary to the concavity, and a biocompatible, flowable material suitable for int...
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Method and Device for Treating Cardiac Arrhythmias

The present invention provides both methods and devices for termination of arrhythmias, such as ventricular or atrial tachyarrhythmias. The device and method involves application of alternating current (AC) for clinically significant durations at selected therapeutic frequencies through the cardiac ...
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Inhibitors of Methionine Aminopeptidases and Methods of Treating Disorders

The invention is directed towards novel naphthoquinone and naphthothiazole compounds, and methods of treating disorders related to MetAP, including tuberculosis and bacterial infection, using various naphthoquinone, hydroxyquinonline, and naphthothiazole compounds....
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Methods for Enhancing Antigen-specific Immune Responses

Methods for delivering naked DNA vaccines to enhance immune responses, by improving transfection efficiency without safety concerns associated with live viral vectors, are described. A method may comprise administering to a mammalian subject an effective amount of a papillomavirus pseudovirion, wher...
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Truncated Activin Type Ii Receptor and Methods of Use

The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In addition, the invention provides a virtual representation of a GDF receptor or a functional peptide portion...
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Novel Liver-targeting Agents and their Synthesis

This invention provides novel liver targeting agents and their synthetic methods. A liver targeting agent, with a lysine based nitrilo triacetic acid structure as backbone which acquires multivalency with saccharide groups, to bind with a galactosamine chain or lactose chain is disclosed. In particu...
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Consensus Sequence for Influenza a Virus

Pandemic A(H1N1) continues its global spread, and vaccine production is a serious problem. Protection by current vaccines is limited by the mutational differences that rapidly accumulate in the circulating strains, especially in the virus surface proteins. New vaccine strategies are focusing at cons...
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Reprogramming Blood Cells to Pluripotent and Multipotent Stem Cells

The present invention is based on the seminal discovery that cord blood (CB) and adult bone marrow (BM) CD34+ cells can be reprogrammed to early stem cells. The invention provides the reprogramming of CB and adult bone marrow (BM) CD34+ cells from subjects without any pre-treatment. Provided are met...
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Non-invasive Methods and Systems for Assessing Cardiac Filing Pressure

Featured are methods and systems for assessing cardiac filing pressure non- invasively. Such methods include, inter alia, arranging a photoplethysmography (PPG) transducer on a finger of a patient and fluidly coupling a pressure transducer to the patient's mouth so that the pressure transducer measu...
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The Fungal Srebp Pathway As a Target for Anti-fungal Agents

Inhibition of Srel activity and/or expression has great potential for antifungal therapeutics. Disclosed herein are novel methods and compositions useful for the identification of novel inhibitors of Srel activity and/or function and the treatment of fungal infections....
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Lysine-specific Demethylase Inhibitors

Polyamine, polyamine/guanidino, and polyamine/biguanide compounds bearing allene, propargyl, cyclopropyl, and other reactive moieties are disclosed. The compounds are useful as irreversible inhibitors of the enzyme lysine-specific demethylase-1 and for the treatment of cancer....
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Method for Identifying and Validating Dominant T Helper Cell Epitopes Using an HLA-DM-Assisted Class II Binding Assay

Rational design of immunotherapeutics relies on clear knowledge of the immunodominant epitopes of antigens. Current methods for identifying kinetically stable peptide-MHC complexes are in many cases inadequate for a number of reasons. Disclosed herein is a reductionistic system incorporating known p...
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Combination Therapy for Tuberculosis

The present invention relates to methods of treating tuberculosis, including multi not drug resistant varieties and latent tuberculosis. More particularly, the present invention relates to a method of treating tuberculosis in a mammal comprising administering to said mammal in need thereof an effect...
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Multitype Hpv Peptide Compositions and Methods for Treatment Or Prevention of Human Papillomavirus Infection.

Embodiments of the invention are directed to methods and compositions of multitype HPV polypeptides....
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Methods for Treating Or Preventing Brain Infections

The invention is directed to methods of treating organ specific infections in a host organism by administering compounds that target host receptors and/or host cellular signaling molecules to prevent a pathogen from infecting the organ. For example, the administration of a compound to prevent a path...
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Universally Deployable and Expandable Bone Screw Anchor Assembly

A self-expanding bone screw anchor assembly adapted to allow the screw body to engage the bone and the anchor to attach thereto. The anchor assembly is adapted to be universally deployed with a variety of installation tools....
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Lrrk2-mediated Neuronal Toxicity

Leucine-rich repeat kinase-2 (LRRK2) mutations are a common cause of Parkinson's disease. Inhibitors of LRRK2 kinase that are protective in in vitro and in vivo models of LRRK2-induced neurodegeneration were identified. The presently disclosed subject matter establishes that LRRK2-induced degenerati...
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Membrane Associated Tumor Endothelium Markers

To gain a better understanding of tumor angiogenesis endothelial cells (ECs) were isolated and gene expression patterns were evaluated. When transcripts from ECs derived from normal and malignant colorectal tissues were compared with transcripts from non-endothelial cells, over 170 genes predominant...
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Methods of Synthesis and Use of Chemospheres

The present invention provides, in general, compositions comprising a hydrogel and an agent, for example a therapeutic agent or an imaging agent, for locoregional delivery. In certain preferred embodiments of the invention, the hydrogel compositions are detectable by Magnetic Responance and CT Scan ...
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Histone Deacetylase Inhibitors, Combination Therapies and Methods of Use

The invention relates to histone deacetylase (HDAC) inhibitors to treat proliferative diseases. The present invention provides novel class III histone deacetylase inhibitors, in particular SIRT1 inhibitors, to reverse the silencing of hypermethylated genes, in combination with one or more other agen...
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Methods and Compositions for Treating and Preventing Autoimmune Diseases

Provided are methods and compositions for treating and/or preventing an autoimmune diseases, including inflammatory bowel disease, rheumatoid arthritis, diabetes mellitus, celiac disease, autoimmune thyroid disease, autoimmune liver disease, Addison's Disease, Sjögren's Syndrome, transplant rejectio...
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Hydrogel-based Vascular Lineage Cell Growth Media and Uses Thereof

A medium for growing vascular lineage cells is described. The vascular lineage cell growth medium includes an oligosaccharide-based hydrogel and a growth factor that promotes vascularization by vascular lineage cells....
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System and Method for Macro-micro Distal Dexterity Enhancement in Micro-surgery of the Eye

A system for operating within an interior region of the eye, or other organ, includes a delivery channel having a proximal portion located exterior to the eye and a distal portion positionable within the interior region of the eye, wherein the distal portion of the delivery channel defines an outer ...
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Methods of Treating Neurological Autoimmune Disorders with Cyclophosphamide

escribed herein are methods for treating neurological autoimmune disorders in which the treatment method includes administering an immunoablative agent to eliminate most or essentially all maturing and mature elements of the immune system in an affected individual. Following this step, the individua...
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Detection and Prognosis of Lung Cancer

Methods and tools are provided for detecting and predicting lung cancer. The methods and tools are based on epigenetic modification due to methylation of genes in lung cancer or pre-lung cancer. The tools can be assembled into kits or can be used seperately. Genes found to be epigentically silenced ...
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Growth differentiation factor receptors, and methods of using same

The present invention provides an activin type IIB receptor (ActRIIB) for use in the treatment or prevention of a muscle disease or disorder in a mammal. The muscle disease or disorder may be muscular dystrophy, muscle atrophy or a muscle wasting disorder....
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Method for Late Introduction of the (8r)-hydroxyl Group in Carbapenem Beta-lactam Antibiotic Synthesis

The presently disclosed subject matter demonstrates that ThnG and ThnQ enzymes encoded by the thienamycin gene cluster in Streptomyces cattleya oxidize the C-2 and C-6 moieties of carbapenems, respectively. ThnQ stereospecifically hydroxylates PS-5 giving N-acetyl thienamycin. ThnG catalyzes sequent...
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Treatment Methods Utilizing Stem Cell Mobilizers and Immunosuppressive Agents

The present invention relates to the field of organ transplantation. In one aspect, the present invention provides methods of treating an organ transplant recipient comprising administering to the recipient a therapeutically effective amount of a stem cell mobilizer and an immunosuppressive agent. I...
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Anti-cytomegalovirus Activity of Artemisinin-derived Dimers

Artemisinin-derived monomers and artemisinin dimers are shown to exhibit in-vitro anti-cytomegalovirus (CMV) activity. Artemisinin dimers effectively inhibited CMV replication in human foreskin fibroblasts and human embryonic lung fibroblasts with no cytotxicity at concentrations required for comple...
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Sr-bi As a Predictor of Human Female Infertility and Responsiveness to Treatment

Methods of diagnosis and treatment of diseases and disorders related to de novo synthesis of cholesterol, based on allelic variants of the scavenger receptor class B type I receptor, and kits for use therein....
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Citrullination of Human Peptidylarginine Deiminase 4 (pad-4) Regulates Its Function and Immunogenicity

The present invention provides peptidylarginine deiminase 4 (PAD-4) polypeptides comprising one or more citrullinated Arginine sites. In one embodiment, a PAD-4 polypeptide comprises a citrulline residue at the following sites: Arg-205, Arg-212, Arg-218, Arg-372, Arg-374, Arg-383, Arg-394, Arg-495, ...
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Psma-binding Agents and Uses Thereof

Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready i...
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Methods and Compositions for Improving Cognitive Function

This invention relates to treating age-related cognitive impairment. This invention in particular relates to the use of inhibitors of synaptic vesicle protein 2A (SV2A), such as levetiracetam, seletracetam, and brivaracetam, in improving cognitive function in subjects that exhibit age-related cognit...
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Compositions and Methods for Enhancing Transport Through Mucus

The invention generally relates to compositions and methods for transporting substances across mucosal barriers. The invention also relates to methods of making and using such substances....
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Compositions and Methods for Treating Cardiovascular Conditions

The invention provides amphiphilic macromolecule encapsulates that are useful for treating cardiovascular diseases including conditions related to or emanating from atherosclerosis....
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Nontoxic Shiga-like Toxin Mutant Compositions and Methods

Disclosed are nontoxic mutants of Shiga-like toxin (Stx1 or Stx2), nucleic acids encoding them, compositions containing the mutants and methods of using the mutants in connection with hemolytic euremic syndrome (HUS). Also disclosed are methods of treating HUS using L3 protein fragments, the nontoxi...
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System and Method for Liver Cell Culture and Maturation

The present invention relates to systems and methods for maturation, proliferation and maintenance of function in cells presenting hepatocyte characteristics and differentiated from stem cells. The cells of the present invention may be generated from stem cell grown in collagen sandwich configuratio...
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Ampicillin and Amoxicillin-based Poly(anhydride-amides)

In one aspect the invention relates to an antibacterial compound of formula II: wherein n is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, or 12; R is H or OH; or a salt thereof. In other aspects the invention also provides devices that include the compound as well as methods for producing an antibacterial eff...
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Endorphin Therapy Compositions and Methods

In certain embodiments, the invention provides methods of isolating and culturing neuronal stem cells from hypothalmi, methods of differentiating the neuronal cells into beta-endorphin neurons, and methods of treatment of various diseases comprising administering agents to differentiate endogenous n...
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Hcv E2 Construct Compositions and Methods

The invention provides a construct comprising the ectodomain of the Hepatitis C virus (HCV) E2 sequence and a mammalian expression system therefore. More particularly, the invention relates to a construct comprising the CMV promoter, prolactin signal sequence, the ectodomain of HCV E2 sequence trunc...
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Inhibition of Dcps

The disclosure relates to methods and compositions (e.g., compounds and pharmaceutical compositions thereof) useful for increasing expression of SMN in a cell (e.g., in vitro or in vivo). As a deficiency in SMN can result in the development of an SMA condition in a subject, the methods and compositi...
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Compositions and Methods for Treating Ophthalmic Diseases

Degradable polymeric compositions containing water-insoluble drugs blended with copolymers of biocompatible diphenol compound monomer units with pendant carboxylic acid groups polymerized with biocompatible diphenol corn-pound monomer units with pendant carboxylic acid ester groups and poly(alkylene...
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Controlled Release of Actives in Skin.

Topical compositions are provided in which active compounds for topical delivery through the stratum corneum are complexed with nanospheres of a triblock copolymer having an A-B-A structure wherein each A end block is a water-soluble, hydrophilic and non-toxic polymer or oligomer; and the hydrophobi...
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Compositions and Methods for Modulating Visceral Sensation and/or Gastrointestinal Reflex Activity

The invention relates to compositions capable of modulating visceral sensation and/or gastrointestinal activity obtained from botanical sources. More specifically, the invention relates to compositions comprising an extract product of an Asclepias plant, and methods of modulating visceral sensation ...
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Micelle Assemblies

The invention encompasses micelle assemblies, compositions having micelle assemblies, and methods for preparing micelle assemblies and compositions thereof. Also, the invention encompasses compounds of the formula: A-X-Y-Z-R1 wherein A is a carboxy group or is absent; X is a polyol, Y is -C(-O)-, -C...
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Treatment of Obesity

The present invention relates generally to a method of increasing lipid oxidation in a mammal and to agents useful for same. More particularly, the present invention relates to a method of increasing lipid oxidation in a mammal by administering a ligand which interacts with the IL-6 receptor and sig...
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Method for Determining the Quality of Heparin

The invention relates to a method for determining contamination of heparin with other sulfated glycans, comprising the steps: incubating a predetermined amount of heparin together with a predetermined amount of an enzyme that specifically digests heparin for a predetermined duration, wherein the amo...
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Pharmaceutical Compositions for Treating Infections with Drug Resistant Mycobacteria

In a first aspect, the present invention relates to pharmaceutical compositions for the treatment of infections with mycobacteria wherein said mycobacteria are resistant to at least one of the following drugs: rifampicin, isoniazid, pyrazinamide, or ethambutol, in particular, said mycobacteria are M...
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Neuroprotective Compositions and Methods

This disclosure concerns novel methods for preventing or treating neurological or neurodegenerative diseases or disorders by using kombo butter acid enriched extracts derived from the seeds of African nutmeg, the main active compounds isolated from the extracts, namely sargaquinoic acid, sargachrome...
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Therapeutic Devices for Patterned Cell Growth

The invention provides therapeutic devices comprising a polymeric anti-inflammatory agent that biodegrades to release anti-inflammatory agents. The therapeutic devices are useful for repair and regeneration of a variety of injured tissues....
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Process for Designing Inhibitors of Influenza Virus Structural Protein-1

Disclosed are methods and compositions useful in identifying inhibitors of influenza virus, such as influenza A and B virus. Also disclosed are methods for preparing compositions for administration to animals, including humans infected with or to protect against influenza virus....
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Compositions and Methods for Treatment of Neuropathic Pain

The present invention relates to compounds, compositions, methods, systems and kits for treating neuropathic pain regulated by SIP30. The present invention provides SIP30 antagonists for the treatment of neuropathic pain....
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Methods to Treat Cancer

The invention provides methods and pharmaceutical compositions for treating certain cancers with compounds of formula (I) wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts and prodrugs....
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Dressing Compositions and Methods

Described is a spray-on hydrogel comprising water-soluble PEG polymers that cross-link in situ to form a hydrogel such that the cross-links are reversible. The hydrogel can be useful as a drug delivery composition, wound dressing or surgery adjuvant. Polyethylene glycol polymer and cross-linker solu...
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Compounds, Compositions and Methods for Treatment of Protozoan Infections

Provided are compounds, compositions and methods for treating protozoan infections....
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Solubilized Topoisomerase Poisons

The invention provides compounds of formula I: wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compound...
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Treatment of Cutaneous Hemangioma

This invention concerns a method of treating hemangiomas with a beta blocker by applying the beta blocker onto the hemangiomas directly. The invention also concerns a combination therapy by using a beta blocker along with a corticosteroid or an alpha adrenergic receptor agonist for the treatment of ...
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Hiv-1 Gp41 Neutralization Domain and Use Thereof

The invention relates to a region of the HIV-I gp41 protein that contains, at least in part, an epitope that allows potent neutralization of resistant virus particles. This site is present in the C-terminal heptad repeat region of gp41 (HR2), and adjacent to, but distinct from the MPER. Vaccines con...
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Antitoxin Destabilization Technology

Disclosed are methods for purifying toxin proteins which avoid denaturation and renaturation procedures....
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Benzo [c] Phenanthridines As Antimicrobial Agents

The present invention provides compounds of formula I: formula (I) wherein X1- X4 and R1-R12 have any of the values defined in the specification, as well as salts and prodrugs thereof, which inhibit major molecular mechanisms associated with bacterial cell division and proliferation so as to be usef...
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Methods and Compositions for Treating Obesity and Related Disorders

The invention provides methods for, and compositions effective for, treating obesity, inhibiting weight gain, treating diabetes mellitus, inhibiting atherosclerosis and treating related disorders and conditions comprising administering a pharmaceutically effective amount of at least one compound cap...
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Bacterial Helicase Inhibitor Compounds and Uses Thereof

Organic compounds are described that inhibit bacterial helicase activity and growth of bacterial cells on surfaces....
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Inhibiting Obesity Progression By Inhibiting Adipocyte Differentiation with a Pre-adipocyte Autophagy Inhibitor

The present invention relates to methods of mitigating, preventing or treating weight gain or obesity in patients by administering one or more autophagy inhibitors, thereby, preventing the differentiation process of pre-adipocyte cells into a mature adipocytes. Specifically, the present invention re...
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Methods and Compositions for Treating Alzheimer's Disease

A method is disclosed for inhibiting the build-up of amyloid plaques in the brain of a patient with at least one risk factor for, or a diagnosis of, Alzheimer's Disease by administering to the patient an amount of one or more compounds effective to inhibit the phosphoryla-tive activity of eEF2K, the...
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Type 5 Adenylyl Cyclase Inhibitors for Providing Cardiac Protection

The invention provides a method of treating a cardiac disease by administering a pharmaceutically effective amount of at least one compound capable of inhibiting AC5 to a patient. The compound capable of inhibiting AC5 may be administered singly or in combination with another agent, such as, for ins...
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Amniopunch and Uses Thereof

A tissue, such as an amniotic or chorionic membrane, harvesting device that integrates a system facilitating subsequent storage of tissue samples. The device cuts a sample of the target tissue and automatically deposits the sample in a storage vessel. A method of collecting and storing a sample from...
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Compositions and Methods to Modulate Cell Membrane Resealing

Disclosed herein are compositions and methods for repairing cell membranes. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the composition facilitates the re...
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Mechanism-based Small-molecule Parasite Inhibitors

Methods for preventing or treating an Apicomplexan parasite infection in a patient administering to a patient in need thereof an effective amount of a compound of Formulas I- IV....
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Use of Stem Cells for Wound Healing

Cells, compositions, and methods of cell therapy for administering a therapeutically effective amount of stem cells or cell concentrate to achieve accelerated wound healing of normal and chronic wounds, while minimizing the formation of scar tissue....
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Closed System Separation of Adherent Bone Marrow Stem Cells for Regenerative Medicine Applications

A method for isolating and processing bone marrow derived stem cells, including the steps of: (a) collecting a biological sample containing adherent bone marrow stem cells in a receptacle with interior walls coated with a cell-adherent substrate; (b) incubating the bone marrow cells on the adherent ...
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Method for Treating Sepsis Or Septic Shock

The present invention is a method for treating sepsis or septic shock using Lipoxin A4....
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Treatment of Hiv Infection

This invention concerns compositions and methods of treating, inhibiting, or controlling HIV infection....
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Treatment and Diagnosis of Inflammatory Disorders

This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders....
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Method for Treating Chronic Nerve Tissue Injury Using a Cell Therapy Strategy

A method for treating a degenerative or traumatic injury to a nerve tissue or the brain by administering at or near the injury site a composition containing adherent bone marrow stem cells suspended in a pharmaceutically acceptable liquid in an amount effective to elicit axonal regeneration or re-my...
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Medical use of mRNA interferase

The present invention is directed to the discovery of a novel family of enzymes designated herein as mRNA interferases that exhibit endoribonuclease activity. The novel finding of the present inventors, therefore, presents new applications for which mRNA interferase nucleic and amino acid sequences,...
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Hemostatic Effects of Glucono-Delta-Lactone

Glucono-delta-lactone (GDL) can be used to mediate the human blood coagulation process. In particular, GDL can be used in an assay to determine an individual's risk potential for accelerated blood clotting or as a treatment for conditions related to accelerated clotting potential and/or inflammatory...
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Method of Treatment for Acute Myelogenous Leukemia

This invention relates to a method of treating acute myelogenous leukemia with TPA along with Dexamethasone and choline magnesium trisalicylate....
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Compositions and Methods Modulating Mg29 for the Treatment of Diabetes

Disclosed herein are compositions and methods for treatment of muscle dysfunction, including diabetes. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the com...
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Rna Targeting in Alpha-synucleinopathies

Therapies and assays to screen for small molecules that can have therapeutic use in the control of neurodegenerative diseases such as Parkinson's and other alpha-synucleinopathies....
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Inhibition of Quorum Sensing-mediated Processes in Bacteria

Methods are provided for identifying molecules that can be used to positively and negatively manipulate quorum-sensing-mediated communication to control bacterial behavior. Small-molecule antagonists that disrupt quorum-sensing-mediated activities are identified. Methods are provided for disrupting ...
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Treatment of Viral Infections By Modulation of Host Cell Metabolic Pathways

Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange...
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Methods for Predicting Disease Outcome in Patients with Colon Cancer

Closures for containers and methods for using same are provided. In a general embodiment/ the present disclosure provides a closure having a top portion (12), a bottom portion (14) and a side portion (16), an aperture (18) extending though the closure, a projection (20) extending from the closure an...
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Inhibition of Glycerol-3-phosphate Acyltransferase (gpat) and Associated Enzymes for Treatment of Viral Infections

A method of treating or preventing a viral infection in a mammal by administering a compound or pharmaceutically acceptable derivative thereof that inhibits a phosphatidic acid synthesis enzyme...
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Angiogenic Resorcinol Derivatives

Novel resorcinol derivatives and methods of preparation and use are presented. These compounds can stimulate angiogenesis as a biological function triggered by the activation of one cannabinoid receptor distinct from CB1 and CB2. Thus, these compounds are specific ligands for one cannabinoid recepto...
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Antimicrobial Compounds

This disclosure relates to compositions including certain compounds identified by a quantitative, high throughput assay to be effective in inhibiting the ability of a bacterium to kill a host organism, as well as methods for using these compounds for treating bacterial infections....
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Methods of Treating Fungal Infections.

Methods of identifying compounds that potentiate the activity of antifungal agents, potentiators identified by these methods, and methods of using potentiators to treat fungal infections are disclosed....
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Synthetic Triterpenoids and Methods of Use in the Treatment of Disease

The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis....
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Method for Selectively Inhibiting the Activity of Acat1 in the Treatment of Alzheimer's Disease

The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the activity of Acyl -CoA: Cholesterol Acyltransferase 1, but not Acyl -CoA: Chole...
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Female Reproductive Tract and Anal Prophylaxes

The present invention provides methods for boosting mucosal immunity in the female reproductive tract of pre- and post -menopausal women using a TGF-beta inhibitor, a Selective Estrogen Receptor Modulator, and/or a recombinant commensal bacterium that expresses endogenous microbicides into the intes...
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System and Method for Providing Patient Registration Without Fiducials

A method for providing patient registration without fiducials comprises the steps of: spatially placing an ultrasound image of a patient randomly at different starting positions relative to a preoperative image; creating an independent registration corresponding to each different starting positions,...
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Compositions and Methods for Treating Cancer

The present invention embraces bis-acridine and bis- quinoline intercalators having a bis (4-aminophenyl) ether tether, and diglycolate salts thereof, for selectively decreasing colon cancer and glial cell proliferation and preventing or treating colon cancers and gliomas....
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Compositions and Methods for Treating Pancreatic Cancer

The present invention provides a method of treating pancreatic cancer by inhibiting the activity cyclin D1 activity in tumor cells. The invention is based on the finding that cyclin D1 shRNA molecules are capable of attenuating tumor growth and interfering with tumor angiogenesis....
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Compositions and methods for preventing or treating a viral infection

The present invention is a composition for enhancing the immunogenicity of viral vaccine. The composition encompasses a viral vaccine in combination with at least one toll-like receptor and, in particular embodiments, an anti-CD40 antibody. The compositions of the instant invention find application ...
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Monocyclic Cyanoenones and Methods of Use Thereof

The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases....
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Methods for diagnosing and treating neuroendocrine cancer

The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods for preventing and treating neuroendocrine cancers are also disclosed....
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Animal model and compounds identified via this model for treatment of chronic pain

An animal model for chronic pain, and in particular lower back pain, is provided. Methods of identifying agents and reducing chronic pain with identified agents such as methotrexate are also provided....
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Absorbable Bone Adhesive Applicator

The instant invention provides of a novel method for repairing bone defects using a polymer blend as well as apparatus for performing such a method. The method includes dispensing a polymer blend either directly on the bone tissue as the fixation means; or secondly in combination with a bone plate, ...
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System and Method for Identification of Fingerprints and Mapping of Blood Vessels in a Finger

In accordance with an embodiment of the invention, there is provided an apparatus for characterizing and identifying a human. The apparatus comprises a light imaging device that images topography of a surface of a portion of human anatomy, and an infrared imaging device that images infrared radiatio...
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Polymeric antioxidants

Antioxidant polymers of the present invention comprise repeat units that include one or both of Structural Formulas (I) and (II): wherein: R is -H or a substituted or unsubstituted alkyl, acyl or aryl group; Ring A is substituted with at least one tert-butyl group or substituted or unsubstituted n-a...
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Inhibitors of Cyclic Amp Phosphodiesterases

Recombinant fission yeast cells and methods of using them are described, which provide for identification of chemical and biological inhibitors or activators of a target exogenous phosphodiesterase (PDE). The invention provides, in some aspects, compounds that inhibit cAMP PDE activity and compositi...
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Sh2 Domain Profiling to Characterize Tyrosine Phosphorylation Signaling in Cancer

A phosphoproteomic method termed SH2 profiling to characterize phosphotyrosine (pTyr) signaling in lung cancer. This method provides quantitative values for the phosphorylated binding sites for Src Homology 2 (SH2) domains, which the cell uses to relay signals from tyrosine kinases. Lung cancer cell...
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Protein-based Artificial Retinas

Multilayer protein films are provided, which comprise native bacteriorhodopsin and/or specialized bacteriorhodopsin mutants as the photoactive element. Also provided are artificial subretinal and epiretinal implants carrying such bacteriorhodopsin films, as well as methods for making and using the s...
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Dialysis Adapter Cell and Method of Use

A dialysis adapter cell includes a housing comprising a plurality of pillars extending between and attached to a top plate and a bottom plate to form a hollow receptacle, wherein the top plate comprises an aperture configured to provide access to the hollow receptacle; a dialysis membrane disposed a...
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Therapeutic Applications of Fatty Acid Amide Hydrolase Inhibitors

Fatty acid amide hydrolase (FAAH) is an enzyme responsible for the degradation of oleamide (an endogenous sleep-inducing lipid) and anandamide (an endogenous ligand for cannabinoid receptors). Disclosed herein are potent inhibitors of FAAH and methods for their use for treating a variety of disorder...
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Methods of Identifying Insect-specific Spider Toxin Mimics.

Disclosed herein are methods of identifying a candidate molecule that mimics at least a portion of the three-dimensional structure of a rU-ACTX-Hvla insecticidal toxin, the method comprising providing a molecular model made from the atomic co-ordinates for the rU-ACTX- HvIa insecticidal toxin as dis...
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Complexes of alpha (2) macroglobulin and antigenic molecules for immunotherapy

The present invention relates to complexes of alpha (2) macroglobulin associated with antigenic molecules for use in immunotherapy. The invention relates to methods for using such compositions in the diagnosis and treatment of immune disorders, proliferative disorders, and infectious diseases....
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Novel Albumin-free Factor Viii Formulation

PROBLEM TO BE SOLVED: To provide a factor VIII formulation for a treatment that is stable in the absence of albumin or other proteins. ; SOLUTION: The factor VIII composition formulated without adding albumin comprises the following excipients in addition to the factor VIII: 4-10% of a filler select...
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Factor Viii Formulations

A Factor VIII (FVIII) composition formulated such that NaCl is not present in the final formulation or is present in trace amounts, which allows for a concomitant reduction in the lyophilization cycle time and increased stability of the lyophilized FVIII....
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Methods and Compositions for Inhibiting Atherosclerosis and Vascular Inflammation

Disclosed herein are compositions and methods for reducing inflammation associated with atherosclerosis and/or vascular inflammatory disease. The methods include administering to a subject in need of treatment for atherosclerosis and/or vascular inflammation a pharmaceutically effective amount of an...
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Compounds for Lysosomal Modulation and Methods of Use

Compounds useful for promoting lysosomal processes and thereby ameliorating the disruption of cellular and functional integrity induced by Ass and other protein and glycoconjugate species are provided. Methods for the treatment of neurodegenerative diseases that involve protein accumulation and aggr...
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Compositions and Methods for the Inhibition of Hepatitis C Viral Replication with Structural Analogs

Compositions and methods for the inhibition of viral replication are provided. In some embodiments, the compositions include a nucleic acid sequence that is identical to a region of the hepatitis C virus (HCV) genome. In other embodiments, the compositions may include a nucleic acid sequence that ha...
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Using Heat Shock Proteins to Improve the Therapeutic Benefit of a Non-vaccine Treatment Modality

The present invention relates to methods of improving a treatment outcome comprising administering a heat shock protein (HSP) preparation or an alpha-2-macroglobulin (alpha2M) preparation with a non-vaccine treatment modality. In particular, an HSP preparation or an alpha2M preparation is administer...
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Method for Obtaining Human Microglial Precursor Cells from Pluripotent Stem Cells

The present invention relates to a method for obtaining human microglial precursor cells, comprising: (a) providing a ceil population comprising neural precursor cells, wherein the cell population is obtainable from embryoid bodies differentiated from human pluripotent stem cells; (b) differentiatin...
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Sensor Arrangement

The invention relates to a sensor arrangement for detecting electromagnetic radiation whose wavelength in or near the infrared range, with at least one measuring chamber (2), which is filled with the radiation to be measured selectively absorbing fluid, the measuring chamber (2) by a windows (3) sea...
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Anticancer Agent

The present invention relates to a pharmaceutical composition for the therapeutic and/or prophylactic treatment of cancer and/or metastasis thereof comprising an amino acid sequence related to a Wech protein and/or a nucleic acid sequence of the gene encoding for the Wech protein....
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Apparatus and Method for Detecting Triacetone Triperoxide

The present invention relates to an apparatus and method for fast and secure online detection of triacetone (TATP)....
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INHIBITORS OF THE NITRATION OF AMYLOID ss PEPTIDES AND THEIR USES IN THE DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE

The present invention relates to a method for identifying an inhibitor of the aggregation of amyloid-ss peptide (Ass), comprising the steps of a) contacting at least one Ass-peptide and/or the nitrated forms thereof with at least one candidate inhibitor that potentially specifically binds to a regio...
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Cytohesin Inhibitors

The present invention relates to a pharmaceutical preparation comprising as an active ingredient a primary amide according to the general formula (1) and/or a secondary amide according to the general formula (2) and their use as a medicament....
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New nucleic acid molecules and polypeptides involved in lipid metabolism

The present invention relates in a first aspect to polypeptides useful for the prevention or treatment of various diseases. In particular, the present invention relates to a polypeptide containing a homeodomain for the prevention or treatment of lipid-based metabolic diseases, cancer, (neuro)degener...
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PPAR gamma agonists for treating illnesses with pathophysiological participation of TH17 lymphocytes

Use of one or more peroxisome proliferator-activated receptor (PPAR)-gamma agonists for treating a disease in which T helper 17 (TH17) cells have a pathophysiologically relevant function, is claimed. - ACTIVITY : Antiarthritic; Antirheumatic; Antipsoriatic; Neuroprotective; Antiinflammatory; Gastroi...
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Adenine Receptor Ligands

The invention relates to adenine receptor ligands useful for treating, alleviating and/or preventing diseases and disorders related to adenine receptor function as well as pharmaceutical compositions comprising such compounds and methods for preparing such compounds. The invention is further directe...
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Anti-HSV antibody

The invention relates to an anti-HSV antibody as defined in the claims, a pharmaceutical composition comprising of an effective amount of the said antibody, an expression vector comprising of a nucleotide sequence which encodes the said antibody, a host cell comprising of the said nucleotide sequenc...
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Pharmaceutical Composition Containing Cannabinoid-receptor Antagonists

The present invention relates to the use of cannabinoid-receptor 2 (CB2R)-antagonists for the prophylaxis and/or treatment of pathogen, in particular, parasitic protozoa, caused or induced cerebral diseases, disorders or conditions including secondary and accompanying diseases, disorders or conditio...
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In-vivo Stimulation Measuring Probe

The invention relates to a measuring probe and a system for the targeted optical in-vivo stimulation of nerve cells and for the electrical measurement of nerve cell pulses. The measuring probe comprises at least one measuring needle for automatically controlled, motorized in-vivo insertion into a br...
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Androgenetic Alopecia

The present invention relates to methods for testing for a predisposition or presence of androgenetic alopecia comprising testing a sample obtained from a prospective patient or from a person suspected of carrying a predisposition for androgenetic alopecia. The invention also relates to a genetic ma...
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POI Prevention

A method is provided, comprising administering at least one guanylhydrazone or salt thereof or a combination thereof to a subject to prevent or ameliorate in said subject at least one of postoperative intestinal inflammation, postoperative ileus, ischemia reperfusion injury, or a combination thereof...
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Methods and Compositions for Promoting Regeneration By Increasing Intracellular Sodium Concentration

The invention provides methods and compositions for increasing the intracellular sodium concentration in a cell....
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Method for Assessing Potential for Tumor Development and Metastasis

The present invention generally provides methods for assessing the potential of tumor formation and/or metastasis using a combination (e.g., a ratio) of the number of circulating tumor cells and the number of circulating cells exhibiting autofluorescence within a selected wavelength region (e.g., re...
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Atoxic Recombinant Holotoxins of Clostridium Difficile As Immunogens

Atoxic Clostridium difficile toxin proteins were expressed in an endotoxin-free Bacillus system top develop a vaccine to reduce incidence and severity of C. difficile infection (CDI). Immunogens evaluated as potential vaccine candidates are mutated toxin A (encoded by TcdA) and toxin B (TcdB), and a...
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Inhibitors of Extracellular Hsp90

The present invention describes the inhibitors of extracellular Hsp90. The inhibition of extracellular Hsp90 leads to a reduction of the invasiveness of the tumor cells. Furthermore, the invention relates to the use of molecules inhibiting extracellular Hsp90 function for the manufacture of a medica...
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Wound Healing Peptides and Methods of Use Thereof

Methods and compositions for the treatment of wounds in a mammalian subject are provided. Particularly, novel polypeptides and encoding nucleic acids that stimulate keratinocyte and endothelial cell motility and/or proliferation are provided....
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Methods, compositions and kits for vegetative cell-based vaccines and spore-based vaccines

Methods for immunizing a subject to an antigen of an infectious agent, a tumor, or an allergen are provided, using vegetative cytoplasmic expression of the antigen or spore surface display of the antigen, and contacting the subject with a composition including a spore or a vegetative cell or both wi...
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Matrix for the production of ligaments, tendons and other tissue

The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matri...
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Multivalent Vaccine Vector for the Treatment and Inhibition of Viral Infection

The present invention features compositions and methods for the treatment or inhibition of one or more viruses using a recombinant viral vector that encodes and expresses at least one viral gene from two or more viruses. The viral genes encoded within the recombinant viral vector may be gene sequenc...
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Compositions and Methods for Treating Ebola Virus Infection

The compositions and methods of the invention described herein provide treatments against Ebola virus infection by expressing gene(s) from the Ivory Coast ebolavirus (ICEBOV) species in a recombinant viral vector....
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Pre-or Post-exposure Treatment for Filovirus Or Arenavirus Infection

The compositions and methods of the invention described herein provide pre- or post-exposure treatments against filovirus or arenavirus infection by expressing one or more genes (e.g., two ore more genes) from filoviruses or arenaviruses in a delivery vehicle (e.g., a recombinant viral vector or a l...
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Polymeric Biolubricants for Medical Use

The present invention provides branched polymers which can be used as lubricants or shock absorbers in vivo. For example, the inventive polymers can be used as viscosupplements, viscoelastics, tissue space fillers, and/or anti-adhesive agents. Also provided are pharmaceutical compositions comprising...
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Supramolecular Bioconjugates

The invention relates to supramolecular bioconjugates and to methods for assembling and utilizing supramolecular bioconjugates. Supramolecular bioconjugates comprise a plurality of first nucleic acids and a plurality of mediators wherein each mediator comprises a second nucleic acid complementary to...
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Metabolic and Cardioprotection By the Myokine Follistatin-like 1 Polypeptide

Described herein are methods and compositions related to the discovery that the Follistatin-like 1 protein (Fstl-1) has metabolic and cardioprotective effects in vivo. Fstl-1 and portions and derivatives or variants thereof can be used to treat or prevent metabolic diseases or disorders and to treat...
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Identification of Novel Pathways for Drug Development for Lung Disease

The invention provides the identification of oncogenic pathways activated in cytologically normal airway cells of individuals having or at risk of having lung disease, as well as specific gene expression patterns (biomarkers) associated with pathway activation. These biomarkers and pathways may prov...
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Knee Brace with Expandable Members and Method of Using the Same

A knee brace (300) has a body (310) supporting first, second, and third expandable members (330). When expanded, the first, second, and third expandable members are positioned on the brace body to provide a counteracting force to the adduction moment of the knee....
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Reca Inhibitors and their Uses As Microbial Inhibitors Or Potentiators of Antibiotic Activity

The present invention provides RecA inhibitors, compositions containing them, systems for identifying or characterizing them, and methods of using them....
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Cell-specifically Effective Molecules on the Basis of Sirna and Application Kits for the Production Thereof and Use Thereof

1. Cell-specifically effective molecules on the basis of siRNA and application kits for the production thereof and use thereof. 2.1. The aim of the invention is to create a link between siRNA and one or more peptides, wherein the siRNA is activated after peptide separation, without the remaining lin...
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Method and Device for Rapid Detection of Bacterial Antibiotic Resistance/susceptibility

Described herein is a method and a device for expediting delivery of an agent to a damaged bacterial cell. In one embodiment, the methods and devices are useful for screening candidate antibiotics. In another embodiment, the methods and devices described herein are used to determine susceptibility o...
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System for Assessing the Efficacy of Stored Red Blood Cells Using Microvascular Networks

A system for assessing the microvascular fitness of a sample of stored red blood cells. The system has a network device having at least one network unit. The network unit has a single inlet and a single outlet for the sample and a plurality of microchannels. The plurality of microchannels receive th...
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Apparatus and Method of Analyzing Arterial Plaque

A method of identifying arterial plaque analyzes arterial plaque using one or more non-invasive tests to determine if the plaque has any of a plurality of hallmarks that are predictive of disruption. The one or more tests do, in fact, test the plaque for the plurality of the hallmarks. The method th...
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Pimap39 Modulates Inflammatory Response

The present invention relates to a novel peptide sequence named PIMAP39 (herein referred to as SEQ ID NO.: 1 ) and methods of use of the novel sequence and functional variants thereof. The present invention also relates to methods for reducing and/or modulating inflammatory responses by administrati...
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Tetrahydropyranonaphthyridines Derivatives, Pharmaceutical Compositions and Therapeutic Treatment Thereof

This invention relates to tetrahydropyranonaphthyridines derivatives having formula (III) or IV: and analogues of the tetrahydropyranonaphthyridines derivatives. The invention also relates to pharmaceutical compositions comprising these compounds and methods for treatment of tuberculosis using these...
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TREATMENT OF IgE-MEDIATED DISEASE

The methods and compositions described herein are based, in part, on the discovery of a polypeptide of soluble CD23 (sCD23) that binds and sequesters IgE. Thus, the sCD23 peptides, polypeptides and derivatives described herein are useful for treating conditions or disorders involving increased IgE l...
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Delivery of H2 Antagonists

The present invention provides improved systems and methods for the local delivery of H2 antagonists. The inventive methods include topical administration of an effective amount of a H2 antagonist encapsulated in liposomes. In certain embodiments, the H2 antagonist, for example, Cimetidine, is encap...
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Thods and Compositions for Preventing Adhesion

This invention provides methods and compositions for preventing post-surgical adhesion formation based on use of an interleukin-16 (IL-16) antagonist, including an IL-16 antagonist peptide and/or an IL-16 antagonist antibody....
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S Isomers of Alpha-methyl Hydrocinnamic Acid for the Treatment of Blood Disorders

The present intervention generally relates to compositions comprising S-isomer of alpha-methyl- hydrocinnamic acid for the treatment and/or prevention of blood disorders and blood deficiencies, as well as methods for treating blood disorders and/or blood deficiency in a subject by administering a co...
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Small Molecule Inhibitors of Hepatitis C Virus

The invention provides derivatives and analogues of triazatetracyclo[7.7.0.01,13,.02,7]-hexadeca-2,4,6,10,12-pentaenes, 5,7,11-triazatetracyclo[8.7.0.01,6.012,17] -heptadeca- 6,8,12,14,16-pentaenes, pharmaceutical compositions comprising these compounds and methods for treatment of hepatitis C viral...
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Glutamine Endopeptidases D'espÈce Rothia Et Utilisation De Celles-ci

Disclosed are glutamine endopeptidase enzymes from Rothia sp. bacteria that are naturally associated with the oral cavity, formulations comprising the glutamine endopeptidase enzymes and the use thereof for the treatment, prevention of allergic reaction and diagnosis of gluten allergy related diseas...
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Methods for Treating Viral Disorders

Disclosed are methods of treating viral disorders via the administration of an inducing agent and an anti-viral agent. In one embodiment, the inducing agent and the anti-viral agent are administered for about five days, and the anti-viral agent is subsequently administered without the inducing agent...
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Compositions for the treatment of blood disorders

The invention relates to compositions containing chemical compounds and compositions containing steel factor which stimulate the expression of hemoglobin or globin protein such as embryonic or fetal globin, or the proliferation of hemoglobin expressing and other cells. These compositions can be used...
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Lipoxin Analogs and Methods for the Treatment of Periodontal Disease

This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease. The invention also provides for methods of t...
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Circulating Mirnas As Non-invasive Markers for Diagnosis and Staging in Prostate Cancer

The present invention relates to a method for staging prostate cancer in a subject suffering from prostate cancer, said method comprises (a) determining the amount of at least one miRNA selected from the group consisting of miRNA-375, miRNA-141, miRNA-200b, miRNA-516a-3p and miRNA9*, or the amount o...
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Human Antibodies Against Hepatitis C Virus (hcv) Uses Thereof.

Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotyp...
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Spinal Muscular Atrophy (sma) Treatment Via Targeting of Smn2 Splice Site Inhibitory Sequences

The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence element, named ISS-N1 (for "intronic splicing silencer"), located in the SMN2 gene. The compositions and methods of the instant invention include...
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Novel Metastasis Suppresor Genes and Uses Thereof

The invention relates to methods for detecting a metastatic cancer, methods for inhibiting tumor metastatic properties, methods for treating tumor metastasis, methods for identifying agents for the treatment of tumor metastasis, and methods for screening for modulators of tumor metastatic properties...
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Lipid-amino Acid Conjugates and Methods of Use

N-fatty acid-amino acid conjugates and J2 prostanoid-amino acid conjugates are disclosed along with methods for making such conjugates and methods of using these conjugates in the treatment of conditions that involve dysfunctional lipid metabolism, insulin sensitivity, glucose homeostasis, and/or in...
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Methods for Treating Endoplasmic Reticulum (er) Stress Disorders

The present invention provides methods for treating ER stress disorders and for identifying compounds for treating ER stress disorders....
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Type Iii Secretion Inhibitors, Analogs and Uses Thereof

The invention, in some aspects, relates to compounds and compositions useful for inhibiting Type III secretion systems in pathogenic bacteria, such as Yersinia Pestis. In some aspects, the invention relates to methods for discovering inhibitors of the Type III secretion system and uses of such inhib...
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Human Antibodies Against Rabies and Uses Thereof

Human monoclonal antibodies that specifically bind to rabies virus, antigen binding portions thereof, and methods of making and using such antibodies and antigen binding portions thereof for treating rabies virus in a subject, are provided herein....
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Methods and Compositions for the Treatment of Sterile Inflammation

Described are methods and compositions that inhibit IL-1 signalling for the treatment of acute inflammatory response to cell necrosis, and the attendant collateral tissue damage....
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Methods of Monitoring Treatment of Aviremic Hiv-infected Patients

Methods of monitoring the efficacy of intensified highly active anti-retroviral therapy (HAART) treatment in aviremic Human Immunodeficiency Virus (HIV)-infected patients....
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Methods for Identifying Modulators of the Pp2a B56 Beta Regulatory Subunit

The present invention is based at least in part on the discovery that the PP2A B56 beta regulatory subunit plays a role in regulating insulin signaling by directly regulating phosphorylation of AKT-I. Accordingly, the present invention features methods of identifying modulators of the PP2A B56 beta ...
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Methods and Compositions for Reducing Inflammation and Treating Inflammatory Disorders

Methods of treating an inflammatory disorder and inhibiting inflammation by administering an inhibitor of a pH-activated protease are provided....
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Compounds for Modulating Rna Binding Proteins and Uses Therefor

The invention relates to compositions and methods for inhibiting RNA binding proteins (e.g., MEX-3, MEX-5 and POS-1), as well as methods for treating and preventing disorders associated with parasitic infections and inflammatory disorders....
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Methods and Compositions for Treating Neurological Disease

This invention relates to methods and compositions for treating neurological disease, and more particularly to methods of delivering iRNA agents to neural cells for the treatment of neurological diseases....
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Compounds for Modulating Tlr2

The present invention is directed to methods, kits, and uses of inhibitors of LCMV mediated NF-?B activation to treat viral infections and inflammatory conditions....
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Methods for Treating Glioblastoma

Described are methods for treating cancers, e.g., glioblastoma, including administering an inhibitor of Notch signalling, e.g., a gamma secretase inhibitor, in combination with a chemotherapeutic agent....
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Tumour-specific P450 Protein

The discovery that CYP1B1 protein is detectable in a wide range of human cancers of different histogenetic types, but is not detectable in non-cancerous tissues, gives rise to diagnostic methods for detecting tumours based on this protein as a marker, and to the possibility of tumour therapies invol...
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Detection of Human Immunodeficiency Virus Co-receptor Tropism in Aviremic Subjects

Methods for detecting human immunodeficiency virus (HIV) co-receptor tropism or replication-competent virus in aviremic subjects, and methods of selecting optimal therapies for aviremic subjects....
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Methods for the Treatment Or Prevention of Diabetes Mellitus and Other Metabolic Imbalances

The invention relates to methods for treatment and prevention of a metabolic imbalance, including diabetes mellitus and other related diseases or disorders, using an extract from a fruit of genus Elaeis....
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Irf As a Tumor Suppressor and Uses Thereof

The invention relates to methods for treating BCR/ ABL mediated disorders. The methods of the invention also include monitoring progression of or sensitivity to treatment of BCR/ ABL mediated disorders as well as identifying subjects for the treatment methods of the invention. Screening assays and r...
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Microna Compositions in the Treatment of Vegf-mediated Disorders

The invention provides methods of treating diseases caused by the over-production of a VEGF polypeptide by administering miRNA or miRNA inhibitor compositions to decrease at least one activity of a VEGF polypeptide....
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A Method for Preventing Or Alleviating the Noxious Effects Resulting from Toxicant Exposure

The present invention provides a method of using agents which can modulate TRPAl function as counteragents to inhibit the physical effects of chemical irritants/toxicants when given prior to exposure or to lessen the physical effects when administered post exposure, and more specifically, to a metho...
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Chimeric Small Molecules for the Recruitment of Antibodies to Cancer Cells

The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalentl...
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Treatment and Prevention of White Matter Injury with Katp Channel Activators

The present invention includes a method of treating or preventing a CNS white matter injury in a patient in need thereof. The invention also includes a method of stimulating proliferation of a CNS cell in a patient in need thereof....
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Compounds and Methods for Treating Viral Encephalitis

The invention includes compositions, methods, and techniques for influencing or otherwise altering or regulating signaling that emanates from ligands, receptors, or pathways of TLR7, and/or IL- 12, and/or IL-23, and/or IL- 17, singly or in any combination. The invention includes inhibiting ligands, ...
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Methods and Compositions for the Detection and Treatment of Preeclampsia

Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia....
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Activated Wnt-beta-catenin Signaling in Melanoma

The present invention is directed to a method of determining the prospects for survival of a melanoma patient. This method involves providing a biological sample from a patient diagnosed with melanoma, determining the level of an indicator of Wnt/ss-catenin activation in the sample, comparing the le...
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Modulation of Sirt1 Expression

Methods are provided for reducing SIRT1 expression by administering a SIRT1 inhibitor. Also provided are methods for treating cardiovascular and metabolic disorders in a subject or delaying or preventing risk factors thereof through the reduction of SIRT1 expression. The present invention is also di...
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Apoptosis-Based Evaluation of Chemosensitivity in Cancer Patients

Induction of apoptosis in target cells is a key mechanism by which chemotherapy induces cell killing. An in vitro system has been established for determining carboplatin and paclitaxel (Taxol) chemosensitivity of epithelial ovarian cancer cells, where measurements of caspase-3 activation are surroga...
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Method and composition for treating immune complex associated disorders

The present invention provides methods and compositions for treating immune complex associated diseases (ICAD), such as SLE, rheumatoid arthritis, and hepatitis-C related immune complex disease (e.g., cryoglobulinemia) in a subject having an ICAD or at risk for developing ICAD. The invention is base...
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C/CLP Antagonists and Methods of Use Thereof

The invention relates to the novel discovery that antagonizing a C/CLP can be useful for the treatment of diseases associated with the upregulation of one or more C/CLP such as Th2-driven and/or IL-13 mediated inflammatory diseases. Accordingly the present invention provides C/CLP antagonists and al...
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Methods of Treating Hepatitis

The present invention relates to a method of treating hepatitis in a patient, which includes administering a pharmaceutical composition that includes carbon monoxide to the patient....
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Diagnosis and Treatment of Age Related Macular Degeneration

Methods, compositions and kits for diagnosis and treatment of age related macular degeneration....
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Method for suppressing immune system response to transplanted tissue or cells

Methods are provided for suppressing the immune system response in recipients of transplanted organs, tissues or cells. An extracorporeal quantity of blood from the intended transplant recipient is treated to induce monocytes contained in the blood to differentiate and form dendritic cells. The matu...
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Compositions and Methods for Treating Or Inhibiting Liver Injury

The present invention relates to the discovery that acetylsalicylic acid (ASA or aspirin), salicylic acid (SA) and related salicylate esters and their pharmaceutically acceptable salts, when coadministered in effective amounts with a drug or other bioactive agent which typically (in the absence of t...
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Herbal Composition Phy906 and Its Use in Chemotheraphy

This invention provides herbal compositions useful for increasing the therapeutic index of drugs, including those used in the treatment of disease, especially viral infections and neoplasms of cancer. This invention provides methods useful for improving the quality of life of an individual undergoin...
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An Objective, Quantitative Method to Predict Histological Subtype in Non-small Cell Lung Cancer

The invention provides a method for determining the histotype of a non-small cell lung cancer tumor which comprises (a) determining the levels of expression of each of thyroid transcription factor-1 cytokeratm 5 cytokeratm-13 and epidermal growth factor receptor in a sample from the non-small cell l...
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Anti-viral nucleoside analogs and methods for treating viral infections, especially hiv infections

The present invention relates to novel compounds according to the general Formulae (I, II, III, IV or V); wherein B is nucleoside base according to the structure Formula (VI); R is H, F, Cl, Br, I, C 1 -C 4 alkyl (preferably CH 3 ), -C N, -C C-R a , Formula (VII); X is H, C 1 -C 4 alkyl (preferably ...
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Nogo Receptor Binding Small Molecules to Promote Axonal Growth

The present invention provides a method for identifying compounds which modulate the interaction of Nogo and Nogo receptor (NgR). The present invention also provides compounds that modulate the interaction of Nogo and Nogo receptor (NgR), the use of such compounds and compositions in the treatment o...
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Methods for Modulating Expression of Creb

Methods are provided for modulating CREB by administering a CREB-specific modulator. Also provided are methods for treating cardiovascular and metabolic disorders in a subject or delaying or preventing risk factors thereof through the modulation of CREB. The present invention is also directed to met...
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Survivin, a protein that inhibits cellular apoptosis, and its modulation

The present invention provides the amino acid of a protein that inhibits cellular apoptosis, herein termed the Survivin protein and nucleic acid molecules that encode Survivin. Based on this disclosure, the present invention provides isolated Survivin protein, isolated Survivin encoding nucleic acid...
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Neovascular-Targeted Immunoconjugates

Immunoconjugates for treating diseases associated with neovascularization such as cancer, rheumatoid arthritis, the exudative form of macular degeneration, and atherosclerosis are described. The immunoconjugates typically consist of the Fc region of a human IgG1 immunoglobulin including the hinge, o...
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Reactivation of Axon Growth and Recovery in Chronic Spinal Cord Injury

Disclosed are methods of treating chronic nervous system diseases or injuries, e.g., chronic spinal cord injury, using Nogo receptor antagonists, including Nogo receptor-1 (NgR1) polypeptides, Nogo receptor-1 antibodies and antigen-binding fragments thereof, soluble Nogo receptors and fusion protein...
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Compositions and Methods for Treating Cancer with Attenuated Oncolytic Viruses

Compositions including attenuated oncolytic viruses and methods of their use for the treatment of cancer are disclosed. Some attenuated virus exhibit potential as tumor therapies by exhibiting characteristics including, but not limited to, high selectivity, infectivity, cytotoxicity, or replication ...
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Aqueous Extract of Pieris Brassicae Larvae and Its Use As Antioxidant

The present research respects to the aqueous extract of Pieris brassicae larvae fed with tronchuda cabbage, which possesses antioxidant activity against radical species prejudicial to health and has capacity to inhibit xanthine oxidase, an enzyme involved in gout development. The compounds present i...
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Hydroxyapatite and Bioglass-based Pellets, Production Process and Applications of Thereof

The present invention refers to hydroxyapatite and bioglass-based pellets of homogeneous size and spherical shape, whose interconnective porous structure, in the micrometer range, allows for an enhanced osteoconductivity and osteointegratioh, with specific application as a synthetic bone graft and t...
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Urinary Gm2 Activator Protein As a Marker of Acute Renal Failure Or the Risk of Developing Acute Renal Failure

The invention relates to a method of determining the risk of developing acute renal failure (ARF) in an individual, or of determining an ARF, and a method of predicting the progression of an ARF, by detecting and/or quantifying the protein Ganglioside GM2 Activator Protein (GM2AP). The failure can b...
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Glycosylated Indolecarbazoles, Method for Obtaining Same and Uses Thereof

Glycosylated indolecarbazoles, method for obtaining same and uses thereof. This invention relates to rebeccamycin and staurosporine derivatives obtained by means of fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and to ...
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Oviedomycin Derivatives, Method for Obtaining Same and Use Thereof

The invention relates to oviedomycin derivatives, the method for obtaining same and the use thereof. The invention relates to oviedomycin derivatives obtained by fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and to pro...
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Therapeutic Use of the Encoding Sequence of the Carboxy-Terminal Domain of the Heavy Chain of the Tetanus Toxin

The present invention relates to the therapeutic use of the encoding sequence of the carboxy-terminal domain of the heavy chain of the tetanus toxin and of the polypeptide encoded by said sequence, preferably for the treatment of amyotrophic lateral sclerosis (ALS)....
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Use of Catecholamine for Differentiation of Stem Cells Into Cardiomyocytes

The present invention relates to the use of catecholamine for differentiation of stem cells into cardiomyocytes and their maturation and a method for obtainment and maturation of these cardiac cells. In addition catecholamine may be used for the preparation of a medicament destined for treatment of ...
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USE OF eNOS INHIBITORS IN NERVOUS REGENERATION

The invention relates to the use of inhibitors of the activity and/or expression of the endothelial isoform of the NO synthase enzyme (eNOS) in the preparation of a medicament for increasing the regeneration speed of damaged peripheral nerves in a patient requiring such treatment. The invention also...
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Use of Maslinic Acid for Treating Nociceptive, Inflammatory and Neurogenic Pain

Use of maslinic acid for treating nociceptive, inflammatory and neurogenic pain. The present invention relates to the use of maslinic acid and any of the derivatives thereof for treating painful pathological processes of a (1) nociceptive, (2) inflammatory or (3) neurogenic nature by any galenically...
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Method for Generating a Virtual Simulated Patient

The invention relates to a virtual simulated patient (talk bot) simulating the behaviour of a patient during a medical consultation such that the responses are as realistic as possible, corresponding to the symptoms of at least one real illness, based on diffuse logic and Markov chains....
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Use of Maslinic Acid for the Treatment of Diseases and the Symptoms Thereof By Means of Cox-2 Inhibition

The invention relates to the use of maslinic acid or natural, synthetic or semi-synthetic maslinic-rich mixtures or of a composition containing said acid for the treatment of pathological processes associated with COX-2 activation, intended, inter alia, for the symptomatic and/or regenerative treatm...
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Use of Virgin Olive Oil Polyphenolic Compounds in Cancer Treatment

The invention relates to the use of polyphenol compounds present in extra virgin olive oil for the treatment of cancer, as well as to pharmaceutical compositions containing same and to the use thereof in the production of drugs....
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Composition for Preventing Or Treating Medical Disorders Associated with Angiogenesis and Cell Proliferation

The invention relates to a composition which includes a statin and an agent activating the vascular endothelium. Said composition can be used for producing drugs or pharmaceutical compositions, preferably for preventing or treating medical disorders associated with abnormal cell proliferation and wi...
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Use of the Masp-52 Protein for the Diagnosis, Treatment and Prevention of Chagas Disease

The invention relates to the use of the MASP-52 protein, from the mucin-associated surface protein (MASP) family, for the diagnosis, treatment and prevention of Chagas disease, including a method for detecting the presence of the T. cruzi parasite in individuals, a method for obtaining data that can...
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Synthetic Analogues of Merosesquiterpenes and Related Compounds Having Antitumoural Activity

The invention relates to antitumoural properties in respect of solid tumours, such as breast, neuroblastomas, lung, colorectal, hepatic and pancreatic cancers both in humans and in animals, of synthetic compounds having a merosesquiterpenic structure related to marine metabolites of puupehenone type...
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Novel (rs)-7- Or 9-(1,2,3,5-tetrahydro-4,1-benzoxazepin-3-il)-7h Or 9h-purines Having Antitumour Activity

The invention relates to compounds intended for use in the treatment of human and animal tumours. Experimental results obtained on breast tumour and non-tumour cells lines suggest that the selected compounds have a specific selective antitumour activity, rendering same excellent candidates for futur...
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Aqueous Solution for the Preservation of Tissues and Organs

It is provided an improved aqueous solution for the preservation of tissues and organs comprising carvedilol, tacrolimus, and trimetazidine. A synergistic effect is observed for this preservation solution which is particularly effective in marginal organs, such as steatotic livers....
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Method and Kit for Predicting the Chances of Survival of Patents with Mantle Cell Lymphoma

Mantle cell lymphoma (MCL) is a distinct subtype of B-cell non-Hodgkin's lymphoma (NHL-B). The invention provides a method and a kit for predicting the chance of survival of a patient suffering from MCL, based on measuring the level of expression of at least four genes selected from the group compri...
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Protein Product for Treatment of Infectious Diseases and Related Inflammatory Processes

The inventors have found that CD6, a member of the Scavenger Receptor Cysteine-Rich (SRSR) superfamily expressed on human lymphocytes binds to Gram-positive and Gram-negative bacteria, as well as to other microbial structures. Thus, a CD6 product is useful for the manufacture of a medicament for the...
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Method for the Prediction of the Severity of Nuclear Envelope-related Diseases.

Nuclear envelopathies are diseases caused by a malfunction of nuclear envelope associated proteins or lamins. Nuclear envelopathies are heterogeneous group of diseases, ranging from muscle and lipid dystrophies to progeria. Genetic screening does not warrant a proper assessment of the impact of the ...
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Method for Screening Compounds for the Treatment Or Prevention of Colon Cancer

The invention is in the field of molecular medicine, more in particular in the field of identifying new compounds for the treatment or prevention of colorectal cancer. The invention provides a method for the screening and/or identification of compounds that are capable of preventing or ameliorating ...
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Method for the Treatment of Ischemia Reperfusion Injury

The invention is in the field of thrombosis, haemostasis, cardiology, medicinal chemistry and/or pharmacology. More particularly, it relates to the use of a mutant activated protein C (APC) for the treatment of ischemia reperfusion injury. A method is provided for treating or preventing reperfusion ...
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Diagnostic and Therapeutic Tools for Diseases Altering Vascular Function

The invention relates to diagnostic and therapeutic tools and applications, particularly useful in diseases that affect vascular health and in inflammatory diseases. In particular, said diagnostic and therapeutic tools employ suitable detection or modulation of endothelial glycocalyx....
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Means and Methods for Diagnosing And/or Treating a Subject At Risk of Developing Heart Failure

The present invention relates to a method for identifying a subject at risk of developing heart failure, comprising: (a) determining the level of one or more biological markers in a biological sample of said subject; (b) comparing the level of said biological marker to a standard level of the same b...
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Two Component Bone Cement Composition for Vertebroplasty

The invention is directed to an intrinsically radio-opaque two component bone cement, comprising a first component which contains at least one acrylate monomer and a second component which contains at least one initiator for the polymerisation of said acrylate monomer, wherein the at least one iodin...
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Treatments Involving Glutaredoxins and Similar Agents

The present invention generally relates to treatments involving glutaredoxins. In one aspect, systems and methods of the invention can be used to treat a subject having an oxidative stress condition, for example, airway inflammation or asthma. In some embodiments, a glutaredoxin may be used to treat...
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Disease susceptibility

The invention provides a method of assessing the susceptibility of a subject to an anxiety disorder or depression, the method comprising determining whether the subject has a haplotype comprising rs3216799, rs6814934, rs765e048, rs2070950 and rs2070951 with respective alleles '+CT', 'C', 'T', 'C' an...
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Organ Protection

The present invention provides compositions, medicaments and methods for use in preventing and/or alleviating the damaging effects of hypoxia and/or reperfusion injury....
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Sphingosine- 1- Phosphate (s1p) Receptor Compounds

The invention relates to compounds, in particular 2-amino- 3, 4, 5, -trisubstituted thiophenes, pharmaceutical compositions containing them and the uses of said compounds and compositions for diseases related to sphingosine-1-phosphate (S1P) receptors, predominantly SlP3 receptors. The diseases incl...
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Use Larch Wood Material for Treating Inflammation

The application of wood material from a tree of the genus Larix for treatment and prophylaxis of inflammation in humans or animals is described. The present invention is based on the use of raw larch wood material as a medicament and an anti-inflammatory food/ feed supplement for animals and humans,...
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Method for Detecting a Wound Infection

he present invention relates to a method for detecting a wound infection comprising the steps of : - contacting a sample obtained from a wound with at least two substrates for at least two enzymes selected from the group consisting of lysozyme, elastase, cathepsin G and myeloperoxidase, and - detect...
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Targets for Retrovirus Associated Diseases

The invention generally relates to retrovirus associated diseases, including diseases caused by human immunodeficiency virus (HIV) or human T-cell leukaemia virus (HTLV). In particular, the invention discloses host proteins targeted by viral proteins in retrovirus associated diseases, and teaches re...
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Surgical procedure for the treatment of female urinary incontinence: tension-free inside-out transobturator urethral suspension

A new, quick, simple, efficient, safe, and reproducible surgical technique for the treatment of female urinary incontinence, in which the posterior urethra is suspended using a tape passed through the obturator orifices from inside (underneath the urethra) to outside (thigh folds). A variety of spec...
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Novel isoform of versican and use in diagnosis and therapy

An isolated and purified nucleic acid molecule having a nucleic acid sequence encoding the V4 isoform of versican, or a fragment thereof of at least 30 nucleotides comprising the exon boundary between exons 8a and 9 and a method and a kit for determining the presence and/or status of a tumor in a ti...
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Water Soluble Curcumin Compositions for Use in Anti-cancer and Anti-inflammatory Therapy

The present invention relates to the medical field. In a first aspect the present invention relates to novel water soluble cyclodextrin-curcumin complexes having a pharmacological activity, in particular an anti-tumour and/or anti-inflammatory activity, and improved physico-chemical properties. In a...
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Combined method for the sequential measurement of (1) the enzymatically active fraction and (2) the total amount of an enzyme

The present invention is related to a combined method and kit (or device) for the sequential measurement of the enzymatically active fraction and the total amount of an enzyme [(such as myeloperoxidase (MPO)] in a sample, and that find improved applications in veterinary and human health fields....
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Method for Generating Islet Beta Cells from Dedifferentiated Exocrine Pancreatic Cells

The present invention relates to an in vitro method for generating insulin-producing beta cells from a population of mammalian cells comprising dedifferentiated exocrine pancreatic cells. The method comprises the step of culturing said dedifferentiated exocrine pancreatic cells in a culture medium i...
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Generation of pancreatic progenitor cells

The invention relates to in vitro methods for producing pancreatic progenitor cells and cell populations from cells having definitive endoderm germ layer phenotype. The invention further encompasses so-obtained pancreatic progenitor cells and cell populations, compositions comprising the same, and f...
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Carboxyethylated Cyclodextrin Polysulfates Useful As Medicaments

This invention relates to novel ss-cyclodextrin polysulfate compounds comprising from one to three 2-carboxyethyl substituents, and at least two sulfates groups per glucopyranose unit, which are useful as active ingredients for the treatment and/or prophylaxis of degenerative joint diseases, osteoar...
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The Use of Topoisomerase Type I Inhibitors to Treat Viral Infections

The present invention relates to the use of compounds, inducing isgylation to treat viral infections. More specifically, the invention relates to topoisomerase type I inhibitors, such as camptothecin and camptothecin derivatives to treat viral infections, preferably infections by RNA viruses. The in...
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Mucosal Membrane Receptor and Uses Thereof

The invention is based on the identification of aminopeptidase N (APN) as the receptor for F4 fimbriae of enterotoxigenic E. coli (ETEC). Based on the observation that oral administration of F4 fimbriae induces a protective intestinal mucosal immune response against a subsequent challenge with F4 ET...
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Synephrine Derivatives for the Treatment of Cancer

This invention relates to a group of synephrine derivatives represented by the structural formula (I), a stereoisomer thereof, a solvate thereof, or a salt thereof, for use in the treatment of cancer, possessing unexpected desirable pharmaceutical properties, in particular for the use in cancer ther...
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Compounds for Use in Therapy

A compound of formula (I) for use in the treatment of a disease of the immune system; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alky...
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Viral Inactivation Process

The invention relates generally to the field of virology. More particularly, the present invention relates to methods for determining the effect of a viral inactivation procedure on the antigenicity of the inactivated virus. In particular for a virus that is a member of the family Arteriviridae or C...
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Mycobacterium Mutants for Vaccines with Improved Protective Efficacy

Tuberculosis (TB) is a major health problem and currently, the only licensed TB vaccine is Mycobacterium bovis Bacille Calmette-Guerin (M. bovis BCG). In the present invention, mutation of mycobacterial components reportedly involved in phagosome maturation inhibition was evaluated for vaccine purpo...
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L-plastin Antibodies and their Use

The present invention relates to antibodies, especially camelid antibodies, binding to the tandem actin binding domain in L-plastin, but not to the single actin binding domains. It further relates to the use of those antibodies to limit cell invasion and metastasis in cancer....
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Vitamin D3 Analogues for the Prevention and Treatment of Bone Disorders

Novel vitamin D analogues are useful for making pharmaceutical compositions for the prevention or treatment of bone disorders such as osteoporosis...
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Method for Alleviating Intestinal Problems and Novel Bacterial Strains Therefor

The present invention relates to butyrate producing bacterial strains related to the species Buty?coccus pullicaecorum to be used in the prevention and/or treatment of intestinal health problems. The present invention therefore provides methods and compositions that overcome the problems associated ...
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Blood Serum Marker for Detection and Diagnosis of Alzheimer's Disease

The present invention relates to a blood marker for early detection and diagnosis of Alzheimer's disease. More specifically, it relates to an analysis of the protein glycan profile in the blood, and the identification of specific peak ratio's when compared to healthy aged matched subjects that are t...
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Use of SIP1 As Determinant of Breast Cancer Stemness

The present invention relates to the diagnosis and treatment of cancer. More specifically, it relates to the use of SIP1 nucleic acid and/or protein for the detection of breast cancer stem cells, and the repression of the gene and/or the inactivation of the protein to repress the differentiation of ...
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Inhibitors of Malt1 Proteolytic Activity and Uses Thereof

The present invention relates to inhibitors of MALT1 proteolytic and/or autoproteolytic activity. More specifically, it relates to compounds such as, but not limited to peptide derivates such as Z-LSSR-CHO, Z-LSSR-CMK, Z-GASR-CHO, and Z-GASR-CMK,and small compounds such as 5-{[5-(3-chloro-4-methylph...
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Inhibition of alpha synuclein toxicity

Present inventions demonstrates that alpha synculein toxicity such as [alpha]-synuclein mediated cell death, alpha synuclein induced reactive oxygen species (ROS) in a cell requires the proapoptotic endonuclease G and that the deletion of the endonuclease G or suppressing of the endonuclease G apopt...
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Methods and Preparations for Protecting Critically Ill Patients

The present invention relates to the use of a polyamine or a salt, solvate, or derivative thereof, such as spermine or spermidine for the treatment or prevention of a life threatening condition, such as multiple organ failure, in a critically ill patient with a non-infectuous disorder....
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Novel Inhibitors of Flavivirus Replication

The present invention relates to a series of novel compounds, methods to prevent or treat viral infections by using the novel compounds, processes for preparation of the compounds, their use to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infect...
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Inhibitors of Lentiviral Replication

The present invention provides peptides having lentiviral replication inhibiting properties, more in particular having antiviral activities with respect to HIV (Human Immunodeficiency Virus). The invention further relates to the use of said peptides as a medicine and in the manufacture of a medicame...
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Bace1 Inhibitory Antibodies

The present invention relates to antibodies with a specificity for BACE1. More specifically, the invention provides monoclonal antibodies which bind to BACE1 and are capable of inhibiting the activity of BACE1 and methods producing these antibodies. Said antibodies can be used for research and medic...
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Thieno [2, 3-B] Pyridine Derivatives As Viral Replication Inhibitors

The present invention relates to a series of compounds of formula (A) having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to methods for the preparation of such compounds, as well as to novel intermediates usef...
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Targeted Radiotherapy

The present invention concerns a therapeutically labeled napthodianthrone or phenanthro[1,10,9,8-opqra]perylene-7,14-dione compound, which comprises a chemical element or an isotope that has an unstable nucleus and emits radiation during its decay to a stable form sufficient to destroy neighboring c...
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Novel Viral Replication Inhibitors

The present invention relates to a series of novel compounds having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to methods for the preparation of such compounds, as well as to novel intermediates useful in one...
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Anti-cancer Combination Therapy

The present invention relates to a combination of therapeutic agents comprising: (a) a cytosine-based anti-cancer drug and/or a purine-based anticancer drug and (b) a therapeutic agent selected from the group consisting of thymidine phosphorylase inhibitors, and antibiotics against Mollicutes bacter...
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Near Full-genome Assay of HCV Drug Resistance

The invention relates to assays for characterization of genotypic mutations of Hepatitis C Virus (HCV) showing a resistance to anti-HCV drugs....
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Inhibition of Tumour Growth and Metastases

The instant invention relates to compounds of formula 1 and their applications as an anti-cancer agent and/or as an angiogenesis inhibitor in mammals, preferably in humans; the instant invention also includes a method of treatment of metastases of prostate cancers using said compound and also a meth...
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Novel Antiviral Agent

The present invention relates the use of a composition including or consisting of at least one element selected from among: a predetermined protein including or consisting of the amino acid sequence SEQ ID NO: 5, and a homologous protein of said predetermined protein, for preparing a drug for preven...
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Macrocyclic Prodrug Compounds Useful As Therapeutics

The present invention includes macrocyclic prodrug compounds, pharmaceutical compositions containing them. The present invention also includes use of these compounds in the treatment of various diseases including an autoimmune disease, an inflammatory disease, a neurological or neurodegenerative dis...
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Anti-aging Compositions Comprising Menyanthes Trifoliata Leaf Extracts and Methods of Use Thereof

An anti-aging composition comprising a skin-beneficial amount of actives identified in Menyanthes trifoliata leaf, wherein the actives are inhibitors of one or more of MMP-1, 2 and 9 and/or scavengers of peroxynitrite. Also disclosed are methods of using such a composition, which include treating th...
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Calcium/sodium Salt of Inositol Tripyrophosphate As an Allosteric Effector of Hemoglobin

The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amo...
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Irreversible Inhibitors Useful for the Treatment of Kinase-related Pathologies

The present invention provides new compounds (I) having a kinase inhibitory activity and useful for treating cancer....
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Synthesis of Resorcylic Acid Lactones Useful As Therapeutic Agents.

Disclosed are macrocyclic compounds of formulae I, I', II, II', III, III', IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and ...
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Method of Reducing Multi-drug Resistance Using Inositol Tripyrophosphate

Inositol trisphosphate (ITPP) causes normalization of tumor vasculature and is a particularly effective cancer therapy when a second chemotherapeutic agent is administered following partial vascularization. ITPP also treats, alone or in combination, multi-drug resistant cancers. ITPP can also be use...
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Methods and Compositions for Treating Cancer

The present invention relates to uses or methods for treating proliferative diseases, in particular cancer, implementing ruthenium compounds, as well as to compositions containing same....
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Calcium/sodium Salt of Inositol Tripyrophosphate As an Allosteric Effector of Hemoglobin

The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amo...
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Hydroxy-bisphosphonic Acid Derivatives As Vector for Targeting Bone Tissue

The present invention relates to hydroxy-bisphosphonic acid derivatives corresponding to general formula (I): in which: - n and m denote, independently of one another, an integer ranging from 1 to 4, - X denotes an oxygen atom or an N-R3 group, - R1 and R3 denote, independently of one another, a lin...
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Modified phosphocalcic compound, injectable composition containing same

A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth ...
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Injectable Calcium-phosphate Cement Releasing a Bone Resorption Inhibitor

The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof....
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Macroporous and Highly Resorbable Apatitic Calcium-phosphate Cement

The present invention is directed to a novel cement powder comprising an organic component consisting of one or more biocompatible and bioresorbable polymers and an inorganic component consisting of one or more calcium phosphate compounds. The invention also relates to the apatitic CPC resulting fro...
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Treatment of Tumours Using T Lymphocyte Preparations

The invention relates to the treatment of a tumour in a patient, by injecting T lymphocytes depleted of regulatory T lymphocytes, and expressing a molecule enabling the specific destruction thereof, wherein the patient receives, beforehand, a non-myeloablative or myeloablative lymphopenia-inducing t...
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Method for Optimizing Blood Cell Transplants

The invention relates to the use of allogenic T lymphocytes for the preparation of a composition intended to be injected into a recipient patient as conditioning for a hematopoietic stem cell transplant, said allogenic T lymphocytes expressing a molecule enabling the specific destruction thereof....
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Tumour-cell-fixing Cells

The present invention relates to an isolated cell capable of fixing tumour cells, expressing the CD10 protein and expressing at least one MDR protein, and to the use of this cell for screening for anti-tumour compounds. Figure: none....
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Use of Interfering RNA for Treating an HIV Infection

The present invention relates to interfering RNA, in particular miRNAs capable of specifically blocking the replication of an HIV virus strain resistant to an antiretroviral compound, and to the use thereof for treating infections by said type of virus....
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Compounds for Preventing and Treating Plasmodium Infections

The present invention relates to the use of at least one compound of formula (I) for the manufacture of a medicament intended for preventing or treating infections by a Plasmodium parasite in an individual, by inhibiting the pre-erythrocytic development stage of said Plasmodium parasite....
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Treatment of Mood and Anxiety Disorders

The invention relates to a selective inhibitor of EIk-1 or MSK-1 activation for use in the prevention and/or treatment of mood and anxiety disorders....
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Tyrosine Kinase Receptor Tyro3 As a Therapeutic Target in the Treatment of Cancer

The present invention concerns new methods for treating cancer by using TYRO3 inhibitors and methods for identifying new molecules of interest for treating cancer....
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Bone Substitute, and Method for the Preparation Thereof

The invention relates to a material that can be used as a bone substitute and to a method for the preparation thereof. The material comprises an organic phase (I) comprising striated collagen fibrils constituted of collagen I triple helices, said fibrils being organized over a large distance accordi...
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Treatment of Retinal Degeneration

The use of a compound having a gon-4-ene nucleus, said nucleus having attached thereto, in the 13 position, a polycarbon-alkyl radical having 2 to about 16 carbon atoms, said compound containing at least 19 and up to 40 carbon atoms in its carbon-carbon skeleton, in the manufacture of a medicament f...
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A Method for the Treatment of Cancer

The invention is based on the surprising finding that treatment with a chemotherapeutic agent such as 5-fluorouracil (5-FU) and an autophagy inducer effectively inhibit the continued growth of, and prevent the recovery following drug withdrawal, of cancer cells. In vivo, drug resistance from a failu...
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Composition and Method for Treatment of Preterm Labor

The invention provides a method for treating or preventing preterm labor in pregnant female subjects. The method comprises the step of administering a therapeutically effective amount of a Toll-like Receptor 9 antagonist sufficient to prevent the activation of Toll-like Receptor 9 by fetal DNA. The ...
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Treatment of Infections

The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in the treatment of microbial infections, particularly those of bacterial origin, including Staphylococcal origin. Ideally, the present inventi...
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Compounds and Methods for the Treatment of Autoimmune and Inflammatory Disease

The present invention provides a method and composition for the treatment and prevention of an autoimmune disease such a multiple sclerosis which is mediated by autoreactive T cells. The administration of a NOD-1 agonist is shown to mediate an anti-inflammatory immune response. NOD-1 agonists suitab...
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Targeting Prodrugs and Compositions for the Treatment of Gastrointestinal Diseases

Provided herein are compounds, compositions and methods for preventing or treating gastrointestinal cancer in a mammal, wherein the method comprises delivering an effective amount of a COX-2 or a similar sulfonamide inhibitor as a prodrug or derivative thereof to the colon, wherein the COX-2 or simi...
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Compositions and Methods for Modulating Toll-like Receptor Activity

The present invention relates to compositions and methods for use in the treatment of conditions such as septicaemia and septic shock. The invention further provides compositions and methods for the suppression of Toll-like Receptor 14 interaction with CD14 during Toll-like Receptor mediated signall...
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Treatment of Microbial Infections

The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in the treatment of microbial infections, particularly those of bacterial origin, including Staphylococcal origin. Ideally, the present inventi...
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Method and Apparatus for Stimulating Pelvic Floor Muscles

A method of and apparatus for stimulating pelvic floor muscles in a patient comprises applying at least one electrode externally to each side of the patient's body in the region of the pelvis, and energising the electrodes to apply a muscular stimulation current which flows laterally across the pati...
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Causal Therapy of Diseases Or Conditions Associated with CNS Or PNS Demyelination

The invention broadly relates to the use of the Active in the causal treatment of a disease caused by axonal demyelination, in which the Active maintains the integrity of myelination (for example by promoting remyelination, and/or preventing demyelination, of the axonal sheaths). The invention is pa...
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Detection and Treatment of an Invasive Cancer Phenotype

A method for the inhibition, prevention or treatment of invasive/metastatic cancer in an individual in need thereof, comprises a step of treating the individual with an agent capable of attenuating the activity of protein selected from the group consisting of: STIPl; and ALDHlAl. Suitably, the invas...
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A Method of Assessing Cancer Status in an Individual

The invention relates to a method of screening patients to identify patients at risk of having a lung squamous cell carcinoma. A sample of serum from the individual is assayed for the abundance of a protein selected from the group consisting of: SEQUENCE ID NO'S: 1 to 11 relative for a control abund...
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A Method of Predicting Response to Thalidomide in Multiple Myeloma Patients

A method of predicting response to thalidomide, or thalidomide analogs, in an individual with cancer, especially cancers for which thalidomide has been implicated as a treatment, such as Multiple Myeloma (MM) employs one or more of a panel of biomarkers that have been shown to be differentially expr...
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HIV-1 Envelope Polypeptides for HIV Vaccine

Immunogenic HIV-1 envelope polypeptides are provided, wherein specificamino acid residues are mutated to repress immunosuppression in GP41, thereby boosting the immune response against HIV-1. Specifically, mutation of those specific residues does not affect the fusogenic propertiesof the viral parti...
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Nanoparticle-mediated Treatment for Inflammatory Diseases

The present invention provides nanoparticles for treatment of inflammatory diseases. The nanoparticles preferably comprise chitosan and a siRNA targeting a mRNA encoding a pro-inflammatory cytokine, such as e.g. tnf-alfa. A preferred route of administration of the nanoparticles is by injection intra...
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Method for Early Detection of Cancer

The present inventors have demonstrated that circulating auto-antibodies to cancer antigens hold promise as specific and sensitive biomarkers for the early detection of cancer. The present invention thus relates to methods of detecting cancer in a sample, comprising utilising a glycopeptide bait der...
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PDZ Domain Modulators

This invention relates to compounds useful as PDZ domain modulators, in particular the PDZ domain of PICK1. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions....
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Methods of Treating Thromboembolic Disorders

The field of the invention relates to methods for dissolving a thrombus using inhibitors of platelet contractility. More particularly, the present invention relates to the use of an inhibitor of platelet contractility in combination with one or more thrombolytic agents and optionally one or more ant...
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Compositions and Methods for the Treatment of Disease

The present invention relates to pharmaceutical compositions for the treatment and/or prophylaxis of disease associated with fibrosis in a vertebrate, said composition comprising at least one activin antagonist, and optionally a pharmaceutically acceptable carrier, adjuvant and/or diluent. The inven...
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Ectopic Pregnancy Treatment

The invention pertains to methods for treating ectopic pregnancy. More particularly, the present invention relates to methods for treating unruptured ectopic pregnancy using a non-surgical method comprising the administration of an EGFR inhibitor alone or in combination with an anti-metabolite e.g. ...
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A Method for Treating Obesity

A method and pharmaceutical composition for treating a disease or condition associated with elevated hypothalamic T cell protein tyrosine phosphatase (TCPTP) such as obesity, weight gain, type 2 diabetes mellitus, insulin sensitivity, impaired glucose tolerance, and inflammation is disclosed. The me...
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STAT3 Inhibitors for the Treatment of Fibrosis

A method of medical treatment or prevention of an interstitial lung disease (ILD) in a subject in need thereof, the method including administering a therapeutically effective amount of a signal transducer and activator of transcription 3 (STAT3) inhibitor to the subject is provided. In other aspects...
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Antisense Molecules and Methods for Treating Pathologies

An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 59....
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Method for Preventing Transport of a Neurotropic Virus

The present invention relates to viruses, particularly to cellular transport of neurotropic viruses and the viral and cellular proteins involved with cellular transport of neurotropic viruses....
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Use of Vitamin D Receptor Agonists and Precursors to Treat Fibrosis

This application relates to methods of treating, preventing, and ameliorating fibrosis, such as fibrosis of the liver, kidney, or pancreas. In particular, the application relates to methods of using a vitamin D receptor agonist (such as vitamin D, vitamin D analogs, vitamin D precursors, and vitamin...
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Detection of Anti-parasitic Compounds

The invention relates to screening compounds for anti-parasitic activity, especially for activity against parasitic apicomplexans using Chromerida....
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TREATMENTS FOR EXCITOTOXICITY AND Ass-MEDIATED TOXICITY AND AGE-ASSOCIATED NEURONAL DYSFUNCTION

The invention relates to compounds for preventing, inhibiting or antagonising fyn from phosphorylating an amino acid residue in a molecule having an amino acid sequence shown in SEQ ID NO: 1. Typically the compound is capable of binding to fyn, to prevent fyn from migrating to a region of a nerve ce...
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Novel Metabolic Disease Therapy

The invention relates to the prevention and treatment of metabolic abnormalities characterized by abnormal glucose metabolism, including diabetes mellitus and new onset diabetes mellitus through the use of fibroblast activation protein (FAP) selective inhibitors....
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Method of Determining Response to Treatment with Immunomodulatory Composition

The present invention provides a method for accurately determining the likelihood that a subject will respond to treatment with an immunomodulatory composition comprising detecting one or more markers in a sample from the subject, wherein at least one markers is linked to a single nucleotide polymor...
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Translocator Protein Ligands

The present invention relates to compounds and methods for imaging translocator protein (18 kDa) (TSPO) expression in a subject. This invention also relates to compounds and methods for the treatment of neurodegenerative disorders, inflammation or anxiety in a subject....
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A Method of Delivering Functional Agents Across the Blood-brain Barrier

The present invention provides a method of delivering a functional agent across the blood brain barrier so that the functional agent is delivered into the brain of the subject, the method comprising the step of administering a polymeric capsule associated with said functional agent to the subject wh...
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Method of treatment and Agents useful for same

The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In...
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Treatment of Chronic Inflammatory Conditions

A method for the treatment of a chronic inflammatory condition in a patient which comprises administration to the patient of an agent which blocks or inhibits IL-3 signalling events in the patient....
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Antigenic complex for the diagnosis and treatment of porphyromonas gingivalis infection

Disclosed is a purified multimeric complex from P. gingivalis, the complex comprising at least one domain from each of RgpA, Kgp and HagA, and having a molecular weight greater than about 300 kDa. Also disclosed are methods for obtaining the antigenic complex and its use to treat Porphyromonas gingi...
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Viral Polypeptides and Methods

The invention is directed to polypeptides and polypeptide fragments from HIV- 1 envelope (Env) proteins following the characterisation of Env structures from environments where HIV isolates expose conserved neutralisation- sensitive Env structures. There is provided a polypeptide being all or a frag...
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Pain treatment

The present invention relates generally to a method for the treatment and prophylaxis of pain. In accordance with the present invention, it is proposed that antagonists of GM-CSF are effective in the treatment of pain. Antagonists of GM-CSF include, but are not limited to, antibodies which are speci...
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Osteoarthritis treatment

The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA). In accordance with the present invention, an antagonist of GM-CSF can be effective in the treatment of osteoarthritis. An antagonist of GM-CSF includes, but is not limited to, an antibody...
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Treatment of Fibrosis

The present invention relates to methods and compositions for treating fibrosis. In one aspect the invention provides the use of an agent capable of increasing the number of stem cells and/or progenitor cells available to and/or engraftment at a site of fibrosis in the manufacture of a medicament fo...
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Tissue Culture Method Using Magnetically Generated Mechanical Stress

PROBLEM TO BE SOLVED: To provide a culturing method of forming connective tissues such as bone, cartilage, ligament and tendon as tissues functioning like mechanical response, and to provide a culturing device. ; SOLUTION: A method for mechanically stimulating tissue forming cells so as to be applie...
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DEVICES AND METHODS FOR DETECTING ss-HAEMATIN AND HAEMOZOIN

In the application, the change in the magnetic state of the haemoglobin caused by the malarial infection is exploited by detecting suitable properties of haemozoin which are dependent on the application of a magnetic field. Figure 1 shows apparatus, shown generally at (10), for performing magneto-op...
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Treatment of Inflammatory Disorders

The present disclosure relates to the treatment of inflammatory disorders. In particular, although not exclusively the present disclosure relates to agents which inhibit a Mas related gene (Mrg) receptor for use in the treatment or prevention of a disorder associated with inflammation. Also included...
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Material Comprising Nm23 Linked to a Substrate for Use in Treating Neuron Disorders

Provided are materials for promoting neuron growth, the materials comprising Nm23 protein, or a biologically effective fragment or derivative thereof, linked to a substrate capable of supporting neuron growth. The Nm23 may preferably be immobilised on the substrate. The materials provided may be sui...
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Method for Diagnosing and Treating Muscular Dystrophy

The invention describes a method for identifying an individual exhibiting symptoms of, or having a propensity to develop muscular dystrophy comprising determining the level of expression in a tissue sample from the individual of one or more proteins selected from pax-7, caveolin-3 and/or fast-myosin...
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Use of VAP-1 Inhibitors for Treating Fibrotic Conditions

The present invention relates to inhibitors of VAP-1 and their use as medicaments in treating fibrotic conditions. Furthermore, the present invention relates to a method of diagnosing a fibrotic condition on the basis of elevated level of soluble VAP-1 or SSAO activity in a bodily fluid, and to a ki...
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Methods of Treatment Using Modified Plasminogen Activator Inhibitor Type-1 Molecules

The present invention generally relates to methods of treating bleeding diseases and disorders and to promote wound healing. The methods comprises administering a procoagulant and a modified plasminogen activator inhibitor type-1 (PAI-1) molecule that displays an increased in vivo half-life of the a...
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Compositions and Methods for Perioperative Bladder Instillation

Polyphenol- and especially catechin-containing compositions (e.g., Polyphenon E) are instilled in the bladder of a subject that previously underwent surgical resection or removal of bladder cancer to reduce cancer growth and/or recurrence....
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Muscarinic Agonists for Neurological Disorders and Methods of Making the Same

Muscarinic receptors with agonist activity and methods of making the same are disclosed. The compound have a thiadiazole compound having a having a quinuclidine ring, a tetrahydropyridine ring, an azobicyclo-heptane ring; or, an azobicyclo-octane ring, wherein a linking group replaces an alkyl sulfo...
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Na/K-ATPase Expression As an Indicator for the Treatment of Cancer

Methods for regulating the expression of Na/K-ATPase and uses thereof, including uses in the diagnosis/prognosis and treatment of cancer, are disclosed....
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System for Concurrent Delivery of Thermobrachytherapy in the Treatment of Cancers

A system combines hyperthermia and radiation treatments in a single treatment modality by using a radioactive seed having magnetic properties....
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A PEG-albumin Composition Having At Least One Protected Thiol Region As a Platform for Medications

This composition comprises a polyethylene glycol-albumin composition having at least one protected thiol region wherein the composition comprises PEG-AlbCys34 with Cys-34 preserved as a thiol. The albumin is linked to medications such as, antioxidants with a reduced sulfhydryl group through the Cys ...
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Soluble Guanylyl Cyclase A1 and A-8r Peptide As Diagnostic Markers of and Therapeutic Targets for Prostate Cancer

The present invention provides materials and methods useful to treat various sGCal- expressing cancers. Materials include peptides which interfere with sGCal's pro-survival functions, thereby resulting in apoptosis of sGCal -expressing cells. In addition, the present invention provides screening ass...
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Non-invasive Ocular Analyte Sensing System

A noninvasive method and apparatus for determining analyte concentration (e.g., glucose) in a subject that includes measuring light refraction from at least a portion one or more structures. One example of such structure is the subject's iris....
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Peptide Manipulators of Regulatory T Cell Activity

The invention relates to peptide inhibitors of Treg cells. Peptides according to the invention are derived from the FOXP3 protein and inhibit its interaction with NFAT. Such peptides are effective to block the interaction between FOXP3 and NFAT and cause apoptosis in mature regulatory T cells. Such ...
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Anti-inflammatory and Wound Healing Effects of Lymphoid Thymosin B-4

The invention relates to a method of treating inflammatory conditions in a subject comprising administering to a subject a composition comprising a lymphoid thymosin-beta4 polypeptide or a functional lymphoid thymosin-beta4 polypeptide variant. The invention also provides a method of promoting wound...
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Male Contraceptive

A compound having formula I. R1, R2, R3 and R4 are independently H or lower alkyl. R5 is aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryloxy, heteroaryloxy, cycloalkyloxy, heterocycloalkyloxy, arylamino, heteroarylamino, cycloalkylamino, heterocycloalkyl amino, arylthio, heteroarylthio, cycloalk...
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Compositions for Use in Cardioplegia Comprising Esmolol and Adenosine

The invention related to a composition for use in cardioplegia, said composition comprising (i) esmolol; and (ii) adenosine, wherein in use the concentration of said esmolol is in the range 0.3-1.5mM, and wherein in use the concentration of said adenosine is in the range 0.1-1.5mM. The invention als...
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Antithrombotic Compounds

A soluble compound for preventing or reducing blood coagulation comprising an antithrombotic agent and a membrane binding element, wherein the antithrombotic agent has a weight of less than about 5,000 daltons. Also disclosed is a soluble compound for preventing or reducing blood coagulation compris...
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Treatment of Central Nervous System Damage

The invention provides a method of promoting neuronal plasticity in the CNS of a mammal, the method comprising administering to the CNS of the mammal an agent that reduces the inhibitory properties of chondroitin sulphate proteoglycans. Preferred agents are chondroitinases and sulfatases, e.g. chond...
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Drug Delivery System Comprising Matrix Metalloproteinase Inhibitors

A composition for topical application to a subjects skin comprising a matrix metalloproteinase inhibitor, more particularly an inhibitor selected from the group consisting of : TIMP-I, TIMP-2, TIMP-3, TIMP-4, Ilomastat, MMP inhibitor 111, CL82198, GM1489, and FN-439 is used for the prevention or tre...
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Antibodies Specific for Misfolded Proteins and Methods for their Production

Methods are provided for producing an antibody specific for a target antigen, in particular, antibodies capable of binding to prion proteins. The methods include adding a target antigen stabilising agent to a sample containing a target antigen, allowing the stabilising agent to stabilise the target ...
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Carrier

Carriers are provided for transport of a substance across the blood-brain barrier. The carriers comprise an antibody specific for a target antigen, in particular, antibodies capable of binding to prion proteins. The antibodies are produced via methods which include adding a target antigen stabilisin...
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Methods and Compositions

A method of inducing relaxation of the cervix of a female mammal, the method comprising administering at least one pharmaceutical agent selected from follicle stimulating hormone or a beta-subunit thereof, luteinizing hormone or a beta- subunit thereof, thyroid stimulating hormone or a beta-subunit ...
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Method and Apparatus for Identifying the Viability of Ischemic Myocardium of a Patient

A method for identifying the viability of is chemic myocardium of a patient. The method includes the steps of measuring in real-time the is chemic myocardium of a beating or non-beating heart, and determining in real-time whether the is chemic myocardium of the beating or non-beating heart is stunne...
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System, software, and method for detection of sleep-disordered breathing using an electrocardiogram

A system to form and store an electrocardiogram (ECG) signal derived from a cardiac electrical signal that includes an apparatus having a pair of the electrodes to connect to a patient to detect the cardiac electrical signal. A signal sampler samples the cardiac electrical signal to form the ECG sig...
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Dry Powder Drug Delivery Formulations, Methods of Use, and Devices Therefore

The present disclosure relates to systems, methods, and formulations for the pulmonary administration of one or more therapeutic agents, in dry powder form, in a single, large dose quantity. These formulations, methods, and systems are useful in the treatment of patients suffering from toxic or harm...
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Hollow Gold Nanospheres (Haunss) and Haunss-loaded Microspheres Useful in Drug Delivery

A near-infrared mediated drug delivery system comprising a plurality of microspheres made of polymeric material, each sphere containing a plurality of hollow gold nanospheres together with drug product, wherein upon NIR irradiation, the drug product is released from the microsphere....
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Combinational Multidomain Mesoporous Chips and a Method for Fractionation, Stabilization, and Storage of Biomolecules

A new fractionation device shows desirable features for exploratory screening and biomarker discovery. The constituent MSCs may be tailored for desired pore sizes and surface properties and for the sequestration and enrichment of extremely low abundant protein and peptides in desired ranges of the m...
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Use of Riboflavin in the Treatment of Hypertension.

The invention provides the use of riboflavin in the manufacture of a medicament for the treatment or prophylaxis of elevated blood pressure in a subject homozygous or heterozygous for the MTHFR C677T polymorphism. The invention also provides a pharmaceutical product for the treatment or prophylaxis ...
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Method of Stratifying Breast Cancer Patients Based on Gene Expression

The present invention assists in prospectively predicting the metastatic likelihood, and thereby, the likely clinical outcome of breast cancer patients, based on the genotype of the patient, in particular, by determining the relative expression level of a set of genes, or subsets thereof. The presen...
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Methods for Reducing Meiotic Non-disjunction

The present invention relates generally to methods for reducing chromosome non-disjunction and aneuploidy during meiosis in mammals by administering to a gamete an effective amount of cdh1, a derivative, variant or homologue thereof, or an agent capable of increasing the expression or production of ...
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Methods of Inhibiting Fibrogenesis and Treating Fibrotic Disease

The present invention relates to the discovery of an epigenetic relay pathway that controls hepatic stellate cell activation and the wound-healing response in fibrogenesis, including fibrogenesis of the injured liver. Methods of inhibiting fibrogenesis, including liver fibrogenesis and secondary dis...
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The Use of Lipid Emulsions for Binding Hepatitus C Virus

The present invention relates to compositions, methods and apparatus for use in the treatment of Hepatitis C Virus infection. The methods and apparatus are all based upon the use of very low density lipid particles which comprise a triglyceride core surrounded by a phospholipid layer that have been ...
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Method of Inhibiting Clostridium Difficile By Administration of Oritavancin

Glycopeptide antibiotics, such as oritavancin, demonstrate significant activity against both a vegetative form of C. difficile and C. difficile spores. Methods for the treatment, prophylaxis and prevention of C. difficile infection and disease in animals, including humans, are described....
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Compositions and Methods for Reducing Macrovascular Complications in Diabetic Patients

The present invention relates to compositions and methods for reducing or ameliorating macrovascular complications in diabetic patients using C-peptide. The compositions and methods of the present invention are for use in controlling or reducing intimal hyperplasia and for reducing the risk of graft...
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Methods and Compositions for Treating Leukemia

A combination of a BCR-ABL inhibitor and a hedgehog pathway inhibitor for the treatment of leukemia....
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Medical Instrument for Grasping an Object, in Particular Needle Holder

A medical instrument for grasping an object, in particular a surgical needle holder, including an elongated shaft, two jaw parts arranged at a distal end of the shaft, at least one of the jaw parts being pivotable with respect to the other of the jaw parts between a grasp state for grasping the obje...
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Treatment for keratinizing dermatological disorders by reduction in keratin expression

Compounds and a method for screening for a compound to reduce the expression of keratin proteins in keratinizing dermatological disorders are disclosed. Preferably keratin expression is reduced by the upstream targeting of the transcription factor stat1 using statins (HMG CoA inhibitors), such as Co...
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Modulation of Rsk

The present invention relates to specific compounds for use in controlling inflammatory cell function and their potential use in modulating an immune response or inflammation. The present invention also relates to the identification of an alternative RSK pathway in, for example, dendritic cells and ...
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Sigma Ligands and IKK / NF - KB Inhibitors for Medical Treatment

The present invention relates to agents that act in concert with sigma receptor ligands to enhance their effectiveness in the treatment of cancer and inflammatory disease. It also relates to methods whereby agents can be identified that will be of use in combination with sigma ligands in the treatme...
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Protein Product for Modifying Cardiovascular Health

A composition for use in the treatment or prophylaxis of conditions mediated by endothelial function in mammals is provided. The composition includes a milk protein hydrolysate generated by treating milk or milk whey protein with a proteolytic enzyme having subtilisin or subtilisin-like activity and...
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Diagnosis and Treatment of Cell Proliferation and Differentiation Disorders Based on the FMN2 Gene

The present invention provides methods for diagnosing cell proliferation and/or differentiation disorders, compounds and methods for treating the same and methods for identifying agents potentially useful in the treatment of cell proliferation and/or differentiation disorders....
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Treatment Or Prophylaxis of Proliferative Conditions

The disclosure relates to novel compounds for use in the treatment or prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express cytochrome P450 1B1 (CYP1B1) and allelic variants thereof. Also provided are pharmaceutical compositions comprising...
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Angina Treatment

A xanthine oxidase inhibitor for use in the treatment of angina is described. The angina may be stable angina pectoris and the treatment may be to eliminate, reduce or alleviate one or more symptoms of angina pectoris (such as chest pain), or may be prophylactic. The xanthine oxidase inhibitor may b...
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Methods

The invention relates to a method of detecting an altered behaviour in a population of cells, said method comprising determining at least one of the following characteristics of the population of cells; (i) the proportion of stem cells, proliferating cells and differentiated cells in said cell popul...
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Mannosylated Butyrophilin Tumour Markers

This invention relates to the finding that butyrophilins (BTNs) are mannosylated when expressed by cancer cells. Methods and compositions relating to the detection and treatment of cancer cells expressing mannosylated butyrophilins (BTNs) are provided....
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Formulations of Viable Cells for Oral Delivery

This invention relates to solid formulations for the oral delivery of live microbial cells which comprise dried viable cells and small amounts of a bile acid binding agent, for example, an anion exchange resin such as cholestyramine. The presence of bile acid binding agents in the formulation signif...
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Methods for Predicting Autoimmune Disease Risk

The invention relates to means and methods for determining whether a subject is at high or low risk of autoimmune disease progression by determining the CD8 or CD4 cell subtype of the subject. Autoimmune diseases of particular interest include vasculitis, systemic lupus erythematosus (SLE), rheumato...
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Treatment of Diseases Related to Hyperactivity of the Complement System

Raising the level of Factor I above physiological levels can be used to treat diseases in which the underlying pathology is linked to overactivity of the C3b-feedback cycle and the generation and pro-inflammatory effects of iC3b. Methods, agents, and compositions for treatment of such diseases are d...
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Modulation of T-cell Mediated Immune Responses

This invention relates to the finding that the binding of SKAPl to RapL plays a role in the LFA-I mediated adhesion of T cells. Methods are provided for the identification of compounds which alter this binding and which may therefore be useful in the modulation of T-cell immune responses....
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Methods for Treating Inflammatory Arthritis

Provided herein are, inter alia, methods of treating subjects suffering from inflammatory arthritis and identifying candidate compounds for treating inflammatory arthritis....
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Visual Perimeter Measurement System and Method

In one example of the invention a patient display is provided on which a fixation graphic or video is shown in substantially the centre of the display, and then target graphics or video are shown at different positions on the display about the centre. A test subject is positioned in front of the pat...
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Treatment of Pre-term Neonates

This invention relates to the treatment of pre-term neonates with paraoxonase 3 (PON3) or serum amyloid A like protein 3 (SAA3) to reduce or prevent the morbidity and mortality associated with prematurity....
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Composition

The present invention relates to a composition for improving stem cell integration. The present invention also relates to a method of improving stem cell integration and kits for improving stem cell integration....
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Neural Interface

This invention relates to the neural interface comprising one or more electrode-coupled microchannels. Each electrode-coupled microchannel comprises a microchannel for accommodating regenerating nerve axons; and one or more electrodes exposed to the interior of said microchannel. The one or more ele...
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Improved Reprogramming of Mammalian Cells, and Cells Obtained

Expression of reprogramming factors such as Sox2, klf4, c-myc, Nanog, LIN28 and Oct4 followed by culture in a MEK inhibitor and a GSK3 inhibitor reprograms tissue cells. The invention provides new uses of these inhibitors, for example in inducing completion of the transcriptional resetting of so-cal...
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Methods of Using Anti-inflammatory Compounds

The invention relates to the use of 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one for preparing a medicament intended to prevent or treat inflammatory disorders....
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Treatment of central nervous system damage

The invention provides a method of promoting neuronal plasticity in the CNS of a mammal, the method comprising administering to the CNS of the mammal an agent that reduces the inhibitory properties of chondroitin sulphate proteoglycans. Preferred agents are chondroitinases and sulfatases, e.g. chond...
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SCD Fingerprints

This invention relates to methods of testing, diagnosing, monitoring, prognostically stratifying and classifying disease, disorders and other medical conditions and physiological states through the detection and analysis of soluble CD antigens in a body fluid sample....
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Processing retinal images using mask data from reference images

Generating output data indicating areas of a retinal image that represent lesions comprises, receiving candidate date associated with a retinal image indicating areas of the image representing candidate lesions; receiving mask data indicating areas of the image that do not represent lesions, the mas...
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Handling blood or plasma by EM radiation - in wavelength region of 200 to 320 nanometres at radiation intensity of 1 joule to 1 kilo-joule per sq. metre

The blood or plasma is irradiated directly after and/or before the material exchange process (haemo-dialysis or plasmapheresis) without direct contact through the conveying system (1). The inner surface of the material transfer system is subjected to a radiation intensity of 1J to 1KJ/sq.m. The star...
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Filter for selective leucocyte removal from blood etc. - has packing material of plant cell walls, not altering concn., function etc. of erythrocytes

Filter for selective elimination of leucocytes from blood, blood preparations or other leucocyte-contg. biological liq. comprises a sieve-like filter base and as column packing an adsorbent made from a framework of plant cell-walls. USE/ADVANTAGE - The method is esp. useful in transition medicine an...
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Polymerase-inhibiting virustatic agent - extracted from root of Cochlospermum angolense as carotenoid, effective against HIV reverse transcriptase, influenza replicase, etc.

The inhibitor contains a compound (I) from the root of Cochlospermum angolense, with appropriate carriers and adjuvants. (I) is a carotinoid drug extract, obtained with water or alcohol from the finely powdered root. The extract is used in crystalline or amorphous form in tablets or capsules, or as ...
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Antiprotozoal compsns. - contain root extract of Cochlospermum angolense

Antiportozoal compsns. contain an active ingredient derived from the roots of Cochlospermum angolense. USE/ADVANTAGE - The compsns. are active against a wide range of human- and animal-parasitic protozoa, including Plasmodium, Naegleria, Giardia, Trichomonas, Leishmania and Crithidia spp.....
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Anthelmintic agent to treat diseases due to worms - contg. carotenoid drug extracted from roots of cochlospermum angolense

Antihelminth agent contains pharmacologically effective doses of the root contents of Cochlospermum angolense and conventional carriers and auxiliaries. Active ingredient is pref. a carotinoid drug extract form the roots of Cochlospermum angolense, esp. in crystallised or amorphic form (in which cas...
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Procedures and cutlery for the digestion of cells and the preservation and extraction of nucleic acids from living cells or tissues

The invention relates to a method for sample fixation, sample preservation, for cell disruption and extraction of nucleic acids in living cells, cell aggregates and tissue samples, and a working set for the implementation of the procedure. The method is to use living cells or tissue fragments of a n...
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Fluorescent probe comprises two complementary hybridization sequences that are separated by a peptide with a recognition sequence for a target molecule, which also separates a donor chromophore from a

Fluorescent probe comprises two complementary hybridization sequences that are separated by a peptide with a recognition sequence for a target molecule, which also separates a donor chromophore from an acceptor chromophore. The length of the peptide is such that the hybridization sequences can hybri...
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Podophyllotoxin

PROBLEM TO BE SOLVED: To provide a prodrug of podophyllotoxin having sufficiently reduced adverse effects by the administration to a patient. ; SOLUTION: There is provided a compound in which the prodrug and the like of the podophyllotoxin are bound. In chemical formula (IV), R1and R2are each 1-10C ...
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Material layer and electro-surgery system for electrosurgical tissue fusion...

The invention relates to a biocompatible material layer for use as an intermediate layer between tissue surfaces to be fused with a fusion of body tissue. The layer of material is such that it causes the body to be fused between tissue surfaces areas of relatively higher electrical resistance and ar...
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Methods for Producing Hair Microfollicles and De Novo Papillae and their Use for in Vitro Tests and in Vivo Implantations

The present invention relates to a method for producing hair microfollicles comprising the steps of: a) providing de novopapillae, b) providing other cell populations selected from the group of fibroblasts, keratinocytes and melanocytes, and co-culturing the de novopapillae with at least one other c...
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Combined Use of TGF-Beta Signaling Inhibitor and Antitumor Agent

The combined use of a TGF-beta signaling inhibitor and an antitumor active substance or an imaging agent modified by a drug-encapsulating macromolecular micelle, or the like, is provided. The selective delivery capability of the antitumor active substance or the imaging agent to the target is improv...
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Contrast Medium-containing Organic-inorganic Hybrid Particle

PROBLEM TO BE SOLVED: To provide a carrier for stably delivering an MRI contrast medium to a target site. ; SOLUTION: The organic-inorganic hybrid particle comprises a block copolymer containing an unchargeable hydrophilic polymer chain segment and a polymer chain segment containing a repeating unit...
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Polyion Complex Comprising PHD2 Expression Inhibiting Substance

Disclosed is a safer and more sustainable gene delivery system or the like, which is effective for treatment of ischemic diseases and the like. Specifically disclosed is a pharmaceutical composition which contains, as an active ingredient, a polyanionic substance that inhibits the expression of PHD2...
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Polymer/metal Complex Composite Having Mri Contrast Ability and Mri Contrasting And/or Antitumor Composition Using the Same

The present invention provides a polymer-metal complex composite, which comprises a block copolymer capable of serving as a constituent member of a polymeric micelle and a metal complex having MRI contrast ability, accumulates in a tumor-specific manner, achieves high image contrast even in a small ...
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Compositions for Cancer Prevention, Treatment, or Amelioration Comprising Papaya Extract

The components of a brew/extract of leaves or other parts of the papaya plant (Carica papaya) or fractionated components thereof are effective in the prevention or treatment of stomach cancer, lung cancer, pancreatic cancer, colon cancer or other solid cancers, or lymphoma, leukemia or other blood c...
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Method of Treating Malignant Mesothelioma

The present invention relates to a therapeutic agent for malignant mesothelioma comprising a substance which inhibits binding of CD26 to extracellular matrix such as an siRNA targeting CD26 cDNA or an anti-CD26 antibody. The present invention also relates to a method of treating malignant mesothelio...
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Endoplasmic Reticulum Targeting Liposomes

Provided are compositions that include lipid particles, such as liposomes, that can fuse with the ER membrane of a cell. The lipid particles can also deliver a cargo, such as a therapeutic or an imaging agent, encapsulated inside the particles inside the ER lumen of the cell. The compositions can be...
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Material for Preventing Tissue Adhesion and Material for Preventing Joint Contracture

The present invention provides a tissue adhesion prevention material preparable at an affected area at the time of surgical procedure by producing a three-dimensional polymeric structure having a flexible structure and high solute permeability in a medium comprising water as the main component under...
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Ultrasonic Probe Supporting Device

PROBLEM TO BE SOLVED: To move an ultrasonic probe along a kneecap to obtain ultrasonic echo information for the cartilage of a knee joint. ; SOLUTION: An attaching unit 16 is positioned by an attaching unit frame 58 to abut to the thigh with the knee in the bending state and a knee abutting part 62 ...
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Knee Acoustic Matching Box for Ultrasonic Probe

PROBLEM TO BE SOLVED: To achieve acoustic matching between the kneecap and an ultrasonic probe when the ultrasonic probe is moved along the kneecap for obtaining ultrasonic echo information for the cartilage of a knee joint. ; SOLUTION: The acoustic matching box includes a water bag 64 filled with w...
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Imaging Technique

The present invention relates to a method of characterising tissue function in a subject in need of such characterisation. The method comprises performing an imaging technique, on a voxel defined within a tissue space of interest, wherein image data is generated over a time period during which the s...
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Tissue Repair Scaffold

A tissue repair scaffold comprising a secondary fibre bundle, the secondary fibre bundle comprising a plurality of primary fibre bundles, each primary fibre bundle comprising a plurality of fibres, wherein the fibres comprise a biocompatible polymer. In embodiments the biocompatible polymer is polyc...
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Treatments and Prevention of Hydrocephalus

The present invention relates to the prevention or treatment of hydrocephalus. In one embodiment, the invention includes the use of one or more bioavailable folate derivatives, or salts thereof, for the prevention or treatment of hydrocephalus. Examples of more bioavailable folate derivatives that m...
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Laser Imaging System to Assess the Vitality of Pulpal Chamber of Teeth

Brief Description Researchers have developed a laser imaging system that accurately assesses the pulp vitality of a tooth. This system can assess and image the pulp vitality without pain to the patient and the method used by the system is non-invasive. Advantages Pulp vitality test is crucial ...
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Portable, Foldable Mirror

The present invention relates generally to mirrors and, more specifically, to a portable mirror having a plurality of foldable mirror panels, each hingedly attached to a main mirror panel. A light fixture is provided and sits at the top of the device, flush with the folding panels when in the closed...
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Digital Staining for Histopathology

Background 99.9 % of cancer cases are diagnosed and monitored by histopathological assessment of a biopsy sample. The presence, concentration and distribution of biological molecules (such as nucleic acid, protein or lipids for example) can be determined by selecting a specific combination of chem...
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Mouse Models of Rhinovirus-induced disease

Background Rhinoviruses cause the common cold, hospitalization of infants, pneumonia in the immunosuppressed and the majority of acute exacerbations of asthma and chronic obstructive pulmonary disease (COPD). These diseases generate hundreds of billions of dollars in healthcare costs, and the morb...
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Bioresponsive Nanoparticle Aggregates

Background Bioresponsive materials offer a promising commercial opportunity and demonstrate great potential in the medical diagnostics and drug delivery sector. Compared with conventional chemistry, they are more sensitive, simple to use and more compatible with biological samples. Enzymes in pati...
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Finger Fracture Fixation

Fractures of the finger bones are a common pathological issue which could lead to temporary or permanent loss of normal function. Fractures close to the joint lead to further complications, often resulting in permanent loss of the affected finger. The kinds of fractures encountered are i) incomplete...
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Adjustable Knee Ligament Fixator

The need for a technique that allows post-fixation graft re-tensioning after anterior cruciate ligament (ACL) reconstruction is indicated by clinical observations of excessive anterior laxity in the immediate and early postoperative period in some people who undergo knee surgery. This may occur in c...
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Treatment of Mast Cell Related Disorders

Isis Project No 3566 CRAC channel blockers provide a novel therapeutic strategy for treating allergic rhinitis and nasal polyposis. Marketing Opportunity Allergy is characterised by an inflammatory response to seemingly harmless substances and it is likely that one in three people will suffer f...
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Efficient Cell Cryopreservation Media

Isis Project No 4026 Oxford researchers have developed cell cryopreservation media with well-defined, serum free agents for preserving adult stem cells, human and animal primary cells. Marketing Opportunity The market size of stem cell research products is estimated to be $800M and expanding th...
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Prostate Cancer Treatment

New prostate cancer treatment that targets prostate cancer cells that have an elevated level of homologous recombination (a DNA repair pathway). Marketing Opportunity Most of the currently available treatments have significant side effects associated with them so quality of life is a major cons...
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Amidobetaine solution for oral care

The patent includes an aqueous composition for oral care use comprising an amidobetaine solution. The solution includes the following five advantages: 1) The process of the present invention gives an amidobetaine composition that is most suitable for oral care applications (mouth rinses and toot...
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A Novel Therapeutic Strategy for HIV Infection

BACKGROUND: Tat is an HIV regulatory protein that is essential for viral replication and HIV disease progression. It critically regulates HIV transcription and allows the generation of full-length transcripts necessary for the formation of virus particles. Tat is also found in the circulation and ca...
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Human Osteoblastic Cell Line with Stably Knocked-Down Vitamin D Receptor

Vitamin D3 is implicated in a myriad of biological responses, many of them mediated via the vitamin D receptor (“VDR”). Researchers at the University of California have developed a human osteoblastic cell line in which VDR activity is substantially and stably reduced. The new VDR knockdown cell l...
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Reversible Inhibitors of Cytosine-C5 DNA Methyltransferase

BACKGROUND: In eukaryotes, the methylation state of a gene specifically affects its transcription. Proper function of the methylation enzyme is crucial for viable development and normal cellular activity. Increased activity of the enzyme cytosine-C5 DNA methyltransferase (DCMTase) has been directly ...
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Rapid Antimicrobial Susceptibility Assay

BACKGROUND: The rising incidence of infectious bacterial strains that are resistant to multiple broad-spectrum antibiotics poses serious complications to the treatment of infectious diseases. Absent knowledge of a given infectious agent's susceptibility to various antibiotics, physicians face the di...
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A device for radiation therapy of rectal cancer

Colorectal cancer patients primarily undergo surgery for treatment followed by chemotherapy. The surgical procedure leads to development of a scar in the region of the body lower to the pelvic diaphragm and between the legs, known as perineal scar. During the radiation treatment, this perineal scar ...
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Highly Hypoxia Specific Gene Expression System By the Combination of the Erythropoietin Enhancer and the Erythropoietin 3'-Untranslated Region for Ischemic Disease Gene Therapy

Gene therapy with VEGF (vascular endothelial growth factor) is a new potential treatment for ischemic heart disease. Currently, VEGF is the most effective therapeutic gene for neo-vascularization and there is a need for it to be regulated. This invention relates to gene therapy and to the compositio...
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An Integrated Wireless Neural Interface for Chronic Recording and Stimulation

The envisioned system integrates, wirelessly, a neural electrode array with a signal processor and a RF-communication module. The neural array can talk simultaneously with many individual neurons on the brain and the entire system can be implanted chronically inside the body thus eliminating the n...
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Cone-Beam Reconstruction Using the Backprojection of Locally Filtered Projections

Technology for X-ray detection in cone-beam geometry is rapidly improving and offers more and more potential for the construction of robust computed tomography systems for high-resolution volume imaging. In order to optimally build such systems, problem of cone-beam image reconstruction needs to be...
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Polymeric Compositions and Methods of Making and Using Thereof

Hydrogels are polymeric compositions, i.e. three-dimensional polymer networks that are capable of absorbing large amounts of water, and swell in water or aqueous fluids without dissolving. The wide variety of medical applications for polymeric compositions demonstrates the need for the development o...
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Drug Delivery System That Targets Bone and Boosts Availability and Solubility of Therapeutic Drugs

In healthy individuals, bone resorption and formation are well balanced, with the bone mass maintained in a steady state. Disturbance of such balance may lead to a number of bone diseases such as osteoporosis, Paget�s disease, osteoporosis and bone cancer. With the worldwide prevalence of osteopor...
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Novel Allele-Specific Primer Design for Quantitative, Sensitive, Allele Frequency Determination

The present invention provides a novel primer design for real-time quantitative allele-specific PCR (AS-PCR), which results in improved sensitivity, specificity and reproducibility of detection. The utility of this approach has been demonstrated by using quantization of JAK2 G88526T SNP somatic muta...
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Metal-based Membranes with Reduced Autofluorescence to Improve Detection and Imaging of Surface Analytes

Increasing the concentration of cells and microorganisms by filtration for solid phase imaging and counting is a rapid, sensitive tool. In addition, filtration is used for purification of genomic DNA from biological samples, which is a requisite initial step in the conducting many molecular diagnost...
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Process and Formulation to Improve Viability of Stored Human Cells and Tissue

There are more than 750,000 tissue and body-part transplants conducted annually, according to the American Association of Tissue Banks. There are many applications that utilize skin grafting: reconstruction after surgery; tissue replacement in burn victims and patients with epidermolysis bullosa (E...
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Drug Delivery System for Macromolecular Treatment of Arthritis and Other Inflammatory Diseases

The technology in this invention is a water-soluble polymeric drug delivery system for the improved treatment of rheumatoid arthritis and other inflammatory diseases. The delivery system consists of a water-soluble polymer backbone, targeting moieties, and antirheumatic drugs. The polymeric backgr...
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A Family of Intracellular Cholesterol Transport Proteins: Potential Drug Targets for Modulation of Cholesterol Homeostasis and Treatment of Coronary Heart Disease and Assay for Activity

This invention provides for a novel therapeutic target for diseases characterized by defects in cellular cholesterol homeostasis. The inventors have identified a member of a family of proteins that catalyzes the incorporation of cholesterol into cellular membranes. This protein represents a novel ta...
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Strategies for Engineering Precise Folding of Proteins, Peptides, and Antibodies

Peptide cyclization is a common strategy to engineer better polypeptide-based therapeutics, or other industrial proteins/peptides. Cyclization and crosslinking are achieved in nature using disulfide bridges. This invention consists of methods to create noncovalent crosslinks in peptides in a manner ...
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Alpha Conotoxin peptides and derivatives as potential therapeutics for nerve hypersensitivity and neuropathic pain

This invention includes alpha-conotoxin peptides isolated from the venom of predatory snails and related synthetic derivatives which antagonize the a9a10 nicotinic acetylcholine receptor, which has been associated with neuropathic pain. These peptides are more specific for this receptor subtype than...
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Method for Oral Decorporation of Metals

Several new diseases involving heavy metal poisoning and radionuclide exposure have been introduced to mankind due to the emergence of new technologies. In addition, the potential for exposure is expected to increase with the continuing industrialization of society. The administration of chelation...
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�O Conotoxins, including MrVIB, with potent and long-lasting analgesic effects

This invention relates to peptides derived from cone snail venom, including MrVIA and MrVIB. These peptides block specific sodium channel subtypes which mediate pain signals in dorsal root ganglion neurons, indicating they may be useful treatment for neuropathic and inflammatory pain. Benefits ...
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Proton-Conductive Nanoporous Opal Membranes

Well studied perfluorosulfonated ionomers such as Nafion� show decreased proton conductivity and degradation above 100oC, methanol permeation and swelling in methanol and water, which limits fuel cell operation to the narrow temperature range. This technology features an inorganic-organic composite ...
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Raman Spectroscopy Apparatus and Method for Continuous Chemical Analysis of Fluid Streams

The present invention provides apparatus and methods for analyzing the chemical composition of fluid streams using Raman spectroscopy. The apparatus includes a laser source for producing light having an excitation wavelength. The light is introduced into a bundle of optical fibers connected to a tub...
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Steroid Profiling in Ovarian Follicular Fluid, Importance for Diagnosis, Prognosis, and Determining Strategies for Treatment

Very sensitive assays for assaying concentration and profile of steroid biomarkers in small volumes of ovarian follicular fluid have allowed identification of specific steroid profiles which are useful for diagnosis of specific endocrine disorders, and assessing ovarian function. Steroid profiles ...
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Steroid-Targeted Therapeutics for the Treatment of Cancer

Cancer is the second leading cause of death by disease in the U.S. It is essential to develop anticancer agents that demonstrate good efficacy without causing systemic toxicity. The cytotoxicity of anticancer agents can be increased by targeting them specifically to the tumor cells. It can be furt...
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Targeted Nanoparticles Conjugated to Chelators as Imaging Agents and for Improved Targeting in Chelation Therapy

Excessive iron stored in the body is a powerful catalyst for the generation of highly toxic free radicals that can damage all molecular classes found in vivo. The progression of many diseases such as atherosclerosis, cancer, diabetes, and neurogeneration disorders can be arrested by depleting the ex...
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Molecule Enhanced Optical Detection by Laser Action

There are numerous florescent molecules used as tags in both medical and biological research. These tags are very specific to the other molecules or sites to which they attach. When excited, the tags emit photons, which are then detected. This technology uses stimulated emission to increase the effi...
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Medicinal Drugs and Health Products from Natural Sources for Treating a Wide Range of Diseases

Areas of rich biodiversity, such as among the tropical forests and coral reefs of the South Pacific, are home to a wide pharmacopoeia of natural molecules which have evolved to regulate the interactions of an organism with its neighbors. Drs. Chris Ireland and Louis Barrows of the University of Uta...
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Ligation-During-Amplification (LDA) for DNA modification

Polymerase chain reaction has traditionally been used for in vitro modification and amplification of linear DNA. On the other hand, circular closed loop DNA is often the form replicated in host cells. In order to modify host cell DNA constructs, the traditional method has been to work with lineari...
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GST polymorphic allele assay

Cancer is the second largest cause of death in developed countries, accounting for nearly one in five of all deaths. Polymorphisms of glutathione S-transferase (GST) enzymes have been correlated with altered risk of several cancers, as well as altered response and toxicity from cancer chemotherapy...
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Vaccine Candidate Genes Directed Against Virulent Group B Streptococcus

Group B Streptococcus algalactiae (GBS) is the most common cause of bacterial infection in human neonates. Type III GBS is responsible for most bacterial meningitis and a large proportion of other invasive infections. Over 90% of type III infections are caused by a genetically related group of organ...
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Siah-1 as a Drug Target for Colorectal Cancer Chemotherapeutics

Colorectal cancer is the second-leading cause of cancer death in the U.S. The American Cancer Society estimates that 56,730 people will die from colorectal cancer in 2004. Sporadic colon polyps and carcinomas carry mutations in the Wnt signaling pathway, which is responsible for degradation of �-c...
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Specific Covalent Immobilization of Proteins through Dityrosine Crosslinks: New Chemistry to Improve Protein Arrays

This invention provides a new immobilization chemistry that combines the versatility of specific protein immobilization with the advantages of site-specific covalent crosslinking. Target proteins are first reversibly surface associated through the well-known interaction of His6-peptide tags and NTA-...
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Supported Opal Membranes

Membranes with nanopores are important in molecular transport, molecule-surface interactions at the nanoscale, and in separations. This invention relates to suspended opal membranes formed by the self-assembly of sub-micron sized silica spheres. The colloidal solutions of 440 nm or 170 nm diameter s...
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Homogenous bioassays and biosensors.

This invention discloses a novel system that involves the use of a short peptide antigen doubly-labeled with fluorescent dye for use in homogenous bioassays and biosensors. Fluorescent energy transfer dyes, which are capable of moving between a more stacked configuration to exhibit fluorescent quenc...
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Compositions and Kits for Fluorescence Polarization Assay of Large Molecules

This invention describes a methodology for determination of high molecular weight antigens based on the principles of fluorescence polarization immunoassay (FPI). An improved oligopeptide composition for use in a fluorescent polarization immunoassay for a high molecular weight analyte is disclosed, ...
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Bioresponsive Polymers Effective in Contraception, Hormone Delivery, and Protection against STDs

Women across the globe face a serious health threat from preventable STD and HIV infections due to the lack of compliance from partners in condom use. Development of a safe and effective method for prevention has a broad market. Currently available methodologies, such as the female condom, sponge ...
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Novel Approaches for the Treatment of Nephrogenic Diabetes Insipidus (NDI)

This invention discloses a novel set of interactions between the prostaglandin and purine signaling pathways that reveal a new class of drug targets for future NDI therapies. Benefits Nephrogenic Diabetes Insipidus (NDI) can be acquired as a result of the use of medicines such as lithium for b...
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Method of High-Throughput Drug Screening

The development of effective drugs remains a challenging, risky and expensive endeavor. Currently it takes an estimated 7-10 years to develop and market a drug at a cost that exceeds $800 million. In addition, advances in combinational chemistry are resulting in a large supply of chemical compounds...
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Noninvasive Thermal Triggering of Hybrid Hydrogels

It is now well recognized that when systemic chemotherapy is used in the treatment of solid tumors, it is almost impossible to achieve therapeutic levels of drug at the tumor site without damaging healthy organs and tissues. One solution to this problem is to encapsulate the drug in a biocompatible ...
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Hydroxy Alkyl Celluloses that Melt at Body Temperature for Food Preparation and Drug Delivery Applications

Cellulose derivatives, owing to their excellent properties and physiological safety, are used widely as thickeners, adhesives, binders and dispersants, water-retention agents, protective colloids, stabilizers and suspension, emulsifying and film-forming agents. Dr. Kiser and his colleagues have dis...
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Novel Genetic Mutations Affecting Intelligence

Decreased mental acuity can stem from multiple sources; i.e., from head trauma, age related diseases, and inherited genetic defects. An estimated 4.5 million Americans have Alzheimer�s disease or some other form of dementia requiring extensive medical and family care. Mental retardation affects app...
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Inhibitors of Ubiquitin Isopeptidases as Pharmaceuticals

For a cell, protein degradation is as essential as protein synthesis. One important intracellular mechanism for protein breakdown is the ubiquitin-proteasome pathway, which functions widely in intracellular protein turnover. In preventing cancer, it is important that inactive tumor suppressor prot...
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Improved Antithrombin III for Circulatory and Cardiovascular Diseases

Blood vessels are lined with heparin-like molecules that serve an anticoagulant function and help to keep blood flowing through the circulatory system. Many artificial vessels and medical devices also feature heparin-coated surfaces that prevent blood clot formation and sustain flow. Heparins requ...
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Circular, Hairpin, Circular/Hairpin, Lariat, and Hairpin-Lariat Hammerhead Ribozymes

Ribozymes are RNA molecules that can catalytically cleave nucleic acids, thereby suppressing expression of unwanted gene products such as disease causing proteins. This technology includes various configurations of the hammerhead-class of ribozymes that contain circular, hairpin, circular-hairpin, ...
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Erythropoietin as a Tissue Regenerating Cytokine for Acute Renal Failure and Other Kidney Diseases

Acute Renal Failure (ARF), in the context of multi-organ failure and in high risk patients, remains a common, and often fatal (~50% mortality), complication. Preventative measures are only poorly effective, and dialysis therapy is expensive and time consuming. ARF is characterized by cell injury a...
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Assay and Drug Target for Ewing's Sarcoma

Ewing�s sarcoma is a highly aggressive bone or soft tissue-associated tumor of children and young adults. The tumor frequently progresses undetected until it metastasizes, whereupon the mortality of the disease greatly increases. This technology reveals a new molecular marker, NKX2.2, which has hi...
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Cancer Systems Biology Website

As biological knowledge continues to grow, searching for how physiological systems function and how they relate to a particular disease becomes ever more difficult. In order to improve the efficiency whereby potential research targets might be identified, this work features an internet portal provi...
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Hydrogels Formulated for in situ Gelation Effective for Drug Delivery and Wound Healing

The high water content and soft consistency of hydrogels make them similar to natural living tissue with numerous applications across the medical field. Under certain conditions it is desirable to prepare a hydrogel at the site of use; unfortunately most polymers must be preformed due to the extreme...
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In Vivo Use of GST-activated Nitric Oxide Donors to Treat Cancer and the Multidrug Resistance Phenotype

A class of enzymes known as Glutathione-S-Transferases (GSTs) is over expressed in many forms of leukemia and solid tumors. This over expression is a major mechanism whereby malignant cells acquire drug resistance. Nitric oxide (NO) is a major biologic effector that inhibits tumor cell growth. A ...
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Biodegradable Elastomers for Medical Use

Polyurethanes are widely used in the medical field due to their wide range of physical properties and biocompatibility. However, they do not have the inherent ability to biodegrade. This invention addresses this by placing linkages of biodegradable esters between poly (urethane) blocks to create a...
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Mycoplasma Arthritidis Mitogen (MAM) Superantigen: a Unique Immunomodulator

MAM is a superantigen (SAg) produced by M. arthritidis, a bacterial species that causes murine arthritis, toxic shock and dermal necrosis. MAM has very little sequence homology with any other SAg, but it is a potent immunomodulator of murine and human T-cells, B-cells, NK cells and macrophages. In t...
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Selective Inhibitors/Activators of PDE3 for Treatment of Heart Failure and Vascular Disease

Nonselective cyclic nucleotide phosphodiesterase (PDE3) hydrolyzes cAMP and regulate its content in cardiac myocytes. PDE3 inhibitors are already used clinically in the treatment of heart failure and peripheral vascular disease. The increased morbidity and mortality seen with the long-term adminis...
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Feedback Dose Control in Thermal Therapy

The American Cancer Society predicted that 1.372 million Americans would be diagnosed with cancer in 2005 and 570,280 would die of it. Improved treatment is imperative for reducing this staggering death rate. Hyperthermia is a promising noninvasive cancer treatment modality that involves the use o...
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Quercetin: a Natural Supplement for Treating and Preventing High Blood Pressure (Hypertension)

This invention defines a nutritional supplement formulation containing an effective amount of quercetin that is specifically dedicated to ameliorating, delaying and/or treating hypertension. An effective dose of quercetin may be administered over the course of multiple time periods or once per day....
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Methods and Apparatus for Minimally Invasive Transverse Aortic Banding: a Useful Tool in the Study of Pathophysiology and Treatment of Pressure-Overload Cardiac Hypertrophy

The present invention provides a curved suture applicator to enable a surgeon to efficiently encircle a target tissue such as a blood vessel with a suture or thread, and a minimally invasive ligation method that utilizes the curved suture applicator to efficiently band the transverse aorta of small ...
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A New Target for Allergy and Asthma Treatment

Eosinophils are a tissue dwelling hematopoietic cell type that likely play a role in parasitic immunity and allergic disease, such as asthma. Activated eosinophils secrete toxic basic proteins such as Major Basic Protein (MBP) which are postulated to cause bronchial hyper-reactivity, damage of the b...
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Rational Design of Anxiolytic and Anticonvulsant Drugs

The balance between neuronal excitation and inhibition is critical for information processing in the brain. When this balance is disrupted, epilepsy and anxiety disorders may result. This balance depends on inhibitory neurotransmission mediated primarily through GABAA receptors. These receptors c...
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Central Medical Image Storage Respository

This invention outlines the establishment of a central digital medical image repository that can be used by multiple institutions within a region or multi-site radiological imaging network. The invention streamlines and reduces the cost of imaging storage and retrieval when compared to traditional...
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Scanning Probe Microscopy Based Diffusion of Dopant and Impurities

It is common to see devices shrink in size with time, especially electronic devices such as computers, cell phones, mobile music players, pagers, calculators etc. There are, however, some important working components in these devices that cannot be replaced by an alternate component but have to be d...
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Computerized Medical Record for Labor, Delivery, Postpartum, & Nursery

This invention, nicknamed OB.exe, comprises a computerized medical record and a database system that actively manages information on normal laboring women and term newborns. The database captures 800 data elements representing more than 90% of the patient�s clinical data (excluding fetal monitoring...
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Method for producing Beta-Carotene on a Large Scale for use in the Medical, Food and Cosmetics Industry

Carotenoids are antioxidant micronutrients reported to protect against the adverse activity of free redicals. Among the carotenoids, Beta-carotene is the most recognized and widely known carotenoid. Flavobacterium multivorum ATCC 55238 is best known for zeaxanthin production, but it was culturally m...
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Image Guided Interstitial Ultrasound Therapy

The Technology The probe’s delivery system includes five independent channels, each capable of producing up to 50W of RF power. An MRI-compatible motor has also been developed to control the rotation of the heating applicator inside the bore of a clinical 1.5T MR scanner. The capability to p...
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Mitochondria Penetrating Peptides

The Background Recent advances in the field of mitochondrial medicine have provided researchers with further incite into the unique structural and functional roles of the mitochondria. Converging lines of evidence have demonstrated the potential role of the mitochondria in a variety of dise...
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Improved Enzymatic Synthesis of Oligosaccharides

Enzymatic synthesis of oligosaccharides, while a great improvement over chemical methods, remains expensive due to the difficulty in producing the nucleotide diphosphate sugars (NDPG’s: e.g. uridine diphosphoglucose, UDPG) that are the substrates for the glycosyl transferases. The Withers group at t...
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Human Lipase Cell Lines

Human hepatic lipase cell line – Chinese hamster ovary (CHO) cells have been stably transfected with a human hepatic lipase cDNA to overexpress this enzyme in cell culture. CHO-HL-Lec1 – This cell line secretes human hepatic lipase in a form with uniform glycosylation to facilitate downstream crysta...
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ABCA1 Monoclonal Antibodies

ATP-binding cassette subfamily A member 1 (ABCA1) plays a pivotal role in the production high-density lipoprotein (HDL) and is a member of the ATPase cassette superfamily of transporters. ABCA1 mutations are associated with impaired cholesterol efflux and reduced plasma HDL which are characteristic ...
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Retinitis Pigmentosa Animal Models

Retinitis pigmentosa is a human genetic disorder that causes blindness due to death of photoreceptors. Many cases of retinitis pigmentosa are caused by a mutation in the rhodopsin gene, rhodopsin P23H. This disorder has been modeled in transgenic Xenopus laevis by expressing the bovine rhodopsin cDN...
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Laser Technique for the Evaluation of Erosion Resistance of Insulating Materials

Dry band arcing is a phenomenon encountered due to the prolonged exposure of high voltage insulation to wet/polluted environment and it is the principal factor that is responsible for degrading the insulating materials by tracking and erosion. Predicting the lifetime of insulators is therefore impor...
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Electric Field Treatment Chamber

The electro-mechanical instability of cell membrane to electrical field is a phenomenon that has been shown to inactivation of micro-organisms in liquid media. This has led to the development of a method referred to as cold-pasteurization for the treatment of liquid foods. The technique has many adv...
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Patient Initiated Emergency Response System (PIERS)

More than one million Americans will suffer an acute myocardial infarction (AMI) this year. Within the first 60 minutes of chest pain, 250,000 will die. Before reaching any medical attention, a total of 375,000, (one-third) will die. Current studies strongly suggest that time-to-treatment is an impo...
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Polygraph Sensor Simulation and Testing System

Polygraph testing invloves the measurement of four physiological responses: blood volume in the arim; respiration rate and volume in the thoracic and abdominal areas; and skin conductivity. Automated polygraph scoring algorithms have been developed to assist polygraph examiners to evaluation polygra...
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Computer-Controlled Neurological Stimulation System

Implanted electrical stimulation devices have been employed in the management of chronic intractable pain for over twenty years. The most common electrode implantation site has been the dorsal spinal epidural space. Spinal cord stimulation, like peripheral nerve or thalamic stimulation, evokes pares...
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A Microfabricated Array Sensor for the Electrochemical Detection of Biological Molecules

The ability to detect ultra low concentrations of heme and hemoglobin in bodily fluids has great value in clinical and medical diagnostic applications. Clinical screening for many diseases, such as colorectal cancer and malaria, is predominantly related to the concentrations of hemoglobin or heme in...
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Cortisol Sensor for Soldier Stress and Fatigue Monitoring

The hormone cortisol, which is produced by the adrenal gland and is released in the body during stressed or agitated states, has gained widespread attention as the so-called "stress hormone." But this hormone is more than a simple marker of stress levels- it is necessary for the functioning of almos...
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Airborne Pathogen Neutralization

So far there is no effective way to disinfect or neutralize airborne pathogens in large volumes of contaminated air in real time to protect citizens against a terrorist attack using biological weapons, or to disinfect air in hospitals. The present inventions provide an apparatus and methods for n...
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Noninvasive Magnetic Sensing of Human Prostate Tumor

Despite the ability of noninvasive electromagnetic bioimpedance methods to measure low contrast changes in tissue, a perennial problem has been the precise localization of the change. Generally, the interrogation or sampling volume is gauged by the diameter of the coil used to impart the electrical ...
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Enhancer of Luminol-mediated Chemiluminescence

The NADPH oxidase of phagocytic leukocytes generates superoxide anion, a toxic oxygen radical important to bacteriostatic and paracitocidal inflammatory responses. Ongoing studies of the oxidase, the components that comprise it, and the signaling pathways leading to its activation are of interest to...
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TH1 Vaccines Based on Replication Attenuated Avirulent Uracil Auxotrophs of an Obligate Intracellular Apicomplexan

Toxoplasma gondii is an obligate intracellular parasite capable of infecting most warm-blooded vertebrates and most nucleated cell types. Parasite transmission occurs primarily by oral ingestion of tissue cysts in undercooked meat or sporozoites in contaminated soil, food, or water. Natural infectio...
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CD161 Ligand, Pilar, for Modulating Activiation and Proliferation of T Cells

CD161 is a C-type lectin receptor initially associated with murine NK cells. Unlike murine lymphocytes, the expression of CD161 in human T cells identifies mostly memory lymphocytes and only a small proportion of invariant NK T cells. CD161 engagement in humans has been recently associated with the ...
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Compounds for Inhibiting, Arresting and Possibly Reversing Non-enzymatic Glycation in Skin

Non-enzymatic glycation and cross-linking (Maillard reaction) are well known processes which accelerate the aging of key biological molecules. For example, non-enzymatic glycation of macromolecules such as proteins and certain phospholipids (e.g., phosphatidylethanolamine and phosphatidylserine) app...
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Methods for Determining Collateral Artery Development in Coronary Artery Disease

Coronary artery disease (CAD) is the most common cause of morbidity and mortality in industrialized societies. Collateral arteries function as “natural bypasses” effectively restoring the blood flow to compromised tissues and play an important physiologic role in promoting survival and protecting ti...
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Prognosis and Treatment of Breast Cancer

Spot 14, also known as thyroid hormone-responsive Spot 14 (THRSP) or S14, is a primarily nuclear protein that is abundant in tissues active in long chain fatty acid synthesis, including the lactating mammary gland. It has been shown that the S14 gene is located on chromosome 11q13 and is overexpress...
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compositions and methods for inhibiting sonic hedgehog activity

Lung cancer is the most common cause of cancer in men and women in the United States. Lung cancer can be divided into two distinct classes, non-small cell lung carcinoma (NSCLC) and small cell lung carcinoma (SCLC). While constitutive Hedgehog signaling has been demonstrated in SCLC, this class repr...
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methods for increasing cardiac MAss and performance

Congestive heart failure (CHF) is a chronic, degenerative condition that impairs the heart's ability to pump blood at normal filling pressures to adequately meet the energy requirements of the body. Multidrug treatment regimens that include diuretics, vasodilators and inotropic agents such as angiot...
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Method for Detecting Cardiac Collateral Formation

Coronary collateral circulation has been recognized as an alternative source of blood supply to an ischemic myocardial area. Collateral artery formation is associated with smaller infarcts, less ventricular aneurysm formation, improved ventricular function, fewer future cardiovascular events and imp...
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compositions and methods for preventing or treating variola virus infection

Variola virus, the most virulent member of the genus Orthopoxvirus, specifically infects humans and causes smallpox. Although smallpox was eradicated in 1980, it remains a potential agent for bioterrorism. As a category A biological weapon, its potential to devastate populations is a concern. Moreov...
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Transgenic Non-human Animal Model of Lung Tumorigenesis

Lung cancer is the leading cause of cancer mortality for men and women in United States. Key molecular changes, especially at early stages of carcinogenesis, represent potential pharmacological targets for lung cancer chemoprevention and therapy. Aberrant expression of cyclin E has been frequently o...
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methods for diagnosing and treating neuroendocrine cancer

Neuroendocrine cancers generally arise from the neuroendocrine system, a diffuse system in which the nervous system and the hormones of the endocrine glands interact. Neuroendocrine cancers also arise from non-endocrine cells which acquire some of the properties of neuroendocrine cells through an on...
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Novel Inhibitor of Hedgehog Dependent Tumors

Sonic Hedgehog (Shh) plays a critical role in the development of numerous structures. Overexpression of Shh has also been implicated in a number of common human tumors, including lung and pancreatic cancer. Tumor cell lines appear to be dependent upon Shh for their survival with Shh acting as a mito...
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A Novel Class of Modulators of the Abc Transporter Family to Improve the Outcomes of Treatment for Cancer Therapy, Secretory Diarrhea, and Cystic Fibrosis

ATP-binding cassette (ABC) transmembrane proteins function to transport small molecules such as drugs across membranes. Dartmouth researchers have identified a protein, which is secreted by the bacterium Pseudomonas aeruginosa, which selectively reduces plasma membrane expression of ABC transmembran...
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Chimeric Nk Receptor and Methods for Treating Cancer

Natural killer cells are innate effector cells serving as a first line of defense against certain viral infections and tumors. Natural killer cells have the ability to recognize and kill a variety of different tumor types using specific cell surface receptors to recognize tumors. These activating NK...
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Drug Resistance and Gene Expression in Biofilms

Biofilms are communities of microorganisms attached to a surface. Biofilm formation in clinical settings, particularly on a variety of medical implants (such as catheters) results in antibiotic resistant infections. These implant-based infections cause prolonged hospital stays and increase in hea...
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Methods of Prevention and Treatment of Diseases Caused By the Fungal Pathogen Candida Albicans

The yeast Candida albicans is the most common fungal pathogen of humans. Most adult females experience sporadic incidents of vaginitis during the course of their reproductive lives and recurrent disease is not unusual. Oral lesions termed thrush regularly afflict infants and immunosuppressed adult...
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Compositions and Methods for Inhibiting the Synthesis Or Expression of MMP-1 for Treating, Preventing, Or Managing

Overexpression of MMP-1 is associated with several pathological conditions, including the irreversible degradation of cartilage, tendon, and bone in arthritis and the degradation of collagens I and III in tumor invasion and metastasis. Patients with tumors that express MMP-1 have an overall poorer p...
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A Novel Pharmacological Pathway which Destabilizes Lysosomes and Targets Oncogenic Or Other Aberrant Proteins for Destruction

Lysosomes are acidic organelles that contain hydrolytic enzymes (such as proteases) that are required for maintaining normal cellular physiology. Lysosomal enzymes participate in diverse cellular functions from degradation of endogenous abnormal or normal proteins to activation or regulation of ess...
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Compositions and Methods for Preventing and Treating Cancer Via Modulating UBE1l And/or ISG15

Individuals with acute promyelocytic leukemia (APL)(FAB M3) express oncogenic promyelocytic leukemia (PML)/retinoic acid receptora (RARa). All-trans-retinoic acid (RA) treatment causes complete remission of APL through induction of leukemic cell differentiation. A hallmark of the RA response in APL ...
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Composition and Methods for Enhancing and Detecting Prion Protein

Prion diseases such as Creutzfeldt Jakob Disease (CJD), bovine spongiform encephalopathy (BSE), chronic wasting disease (CWD), and scrapie are fatal, infectious, neurodegenerative diseases that occur in humans and other mammalian species. The conversion of a normal host prion protein (PrP) into a p...
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Novel Immunotherapy for Ovarian Cancer

Dartmouth investigators and their colleagues at the University of Kansas have discovered a novel method for rescuing cytotoxic T lymphocytes from destruction by ovarian carcinoma cells in vitro using an animal model system. Ovarian cancer causes more deaths than all other gynecologic cancers...
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Use of Monocyte Chemoattractant Protein-1 (MCP-1) for Treatment of Neuropathic Pain

Chronic pain is a dominant health problem. It is the most common reason to seek a physician's care with nearly 40 million office visits scheduled annually. Pain costs the U.S over $100 billion each year in health care costs and lost productivity (NIH Guide, Vol. 24, 1995). Chronic pain is the mos...
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Implantable Biotelemetry System for Preterm Labor and Fetal Monitoring (ARC-14280)

Abstract: The Fetal Treatment Center (FTC) at UC San Francisco has developed a revolutionary surgical procedure to treat fetuses suffering from diaphragmatic hernia, a condition in which a hole in the diaphragm allows internal organs to shift from the abdominal cavity into the chest cavity....
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Rapid Generation of Pulse Flash Free Radicals to Kill Human Cancer Cells, Recycle Human Urine, and Mineralize Organic Chemicals in Wastewater by Using Metallic Cations and Hydrides

Description This invention relates to use the reactions between cationic metals and hydrides to generate free radicals and undergo subsequent oxidation to destroy organic chemicals and kill human cancer cells. Applications The inventors have demonstrated the following novel applications of the pr...
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Human Consumable Essential Oil Highly Toxic to Pest Tephritid Fruit Flies

Description We discovered that an essential oil and its constitutes are very toxic to pest tephritid fruit flies including Ceratitis capitata (Wiedemann) (Mediterranean fly), Bactrocera dorsalis (Hendel) (oriental fly) and B. cucurbitae (Cocquillett) (melon fly). Pest tephritid fruit flies directly ...
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Method and Device for Biochemical Sensing

Description Medical diagnostics using chemical sensing of antibody, antigens, DNA fragments and other biochemicals are addressed using semiconductor sensors and supportive biochemical processes. This successful marriage of semiconductor sensors and biochemistry address a diversity of potential bioch...
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Laser/Fiber Optic, Piezoelectric, Scanning Confocal Microscope

Description The design includes piezoelectric bimorph bender elements that scan the aperture in the confocal image plane to create a compact, relatively inexpensive, rugged confocal microscope which can be remotely deployed on a fiber optic cable and miniaturized for in situ analysis. The scanning u...
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Monoclonal Antibody DZ-1 for M. leprae (leprosy bacillus)

Description The DZ-1 monoclonal antibody detects specific antigen for the leprosy bacillus, Mycobacterium leprae. The recognized antigen is Phenolicglycolipid-I (PG-I). The monoclonal antibody reacts with the innermost sugar (0-3-methylrhamnose) of the trisaccharide antigenic component of the PG-I. ...
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Detection and Identification of Enteric Pathogens

Description Two pairs of DNA primers have been designed to be used in the Polymerase Chain Reaction System (PCR) to consecutively detect both Salmonella and Shigella. The method used to detect the bacteria involves isolating and purifying nucleic acids and using the primers in the PCR system to ampl...
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Serotype-Specific Probes and Nucleotide Sequences of Listeria Monocytogenes Cluster IIB (4b-4d-4e)

Description Two genes which are unique to serotype cluster IIB (4b - 4d - 4e) have been characterized for Listeria monocytogenes. Serotype 4b is known to be the primary pathogenic species causing listeriosis. The serotype-specific region has been sequenced in its entirety from both strands. The sequ...
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Silkworm/Baculovirus Expression System for Production of MSP1 Malaria Vaccine

Description Malaria is a tropical disease that annually infects 200 million people in developing countries, with an estimated 2 -2.5 million people, mostly children, that die of this disease. Globally, over one billion people are at risk of contracting malaria infections. Malaria has continued to ex...
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Optimization of Expression Construct and Purification Protocols for a MSP1.42 Malaria Vaccine

Description The invention consists of two parts which both contribute to an enhanced feasibility of commercial production of this potential malaria vaccine: (1) optimization of the MSP1.42 gene construct for enhanced levels of production in the baculovirus/insect cell culture expression system, and ...
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Baculovirus Produced P. falciparum Vaccine

Description The technology covers the construct consisting of the baculovirus polyhedron promoter, the yeast flg5 leader sequence, and the p42 MSP1 sequence with the transmembrane domain deleted cloned at the University of Hawaii from the Uganda-Palo Alto isolate of P. falciparum. The patent applica...
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Taccalonolide Microtubule-Stabilizing Agent

Description This new microtubule-stabilizing agent is an effective cytotoxin against many cancer cells in vitro. Bioassay-directed purification of the crude lipophilic extract yielded a steroid with paclitaxel-like microtubule-stabilizing activity. Non-transformed cells treated with the agent exhibi...
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Method of Visualizing Chromosomes of Somatic Cells that Do Not Divide

Description Examination of mitotic chromosomes is essential for cytogenetic research, in particular for the chromosomal mapping of the genes responsible for some genetic disorders and cancers linked with the chromosomal alterations. Till today, no methods have been developed to visualize mitotic chr...
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Diagnosis and Treatment of Pre-Term Labor

Description Pre-term birth is a serious medical problem in the U.S. with almost half a million babies born prematurely each year. In spite of all recent medical advancements, the premature birth rate continues to climb and the reasons remain unknown. Pre-term birth is the leading cause of neonatal d...
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Monoclonal Antibodies against Human Flightless-I Protein

Description The Flightless-I Protein was originally identified in the vinegar fly Drosophila but it is conserved in most multicellular organisms, including humans. Studies have shown that mutations in this gene result either in abnormal muscle function or in arrested development and embryonic lethal...
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Novel Fluorescent Nanosensor Proteins

Description Two innovative sensor-protein platforms have been developed by UH researchers. These sensors are designed for highly sensitive fluorescence resonance energy transfer (FRET)-based molecular assays. Both sensors are suited for homogeneous assays, with one of the sensors designed for noncom...
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A Novel Optical Sensor Configuration

Description A novel optical-fiber sensor configuration has been developed for use in parallel bioreactor arrays and other potential applications. A major advantage of this configuration (as opposed to the commonly applied backscattering configuration) is that it minimizes or eliminates the effect of...
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Urine Preservative with Combined Antibacterial and Antioxidant Properties (MSC-22695)

Abstract: The Urine Preservative with Combined Antibacterial and Antioxidant Properties preserves urine analytes at ambient temperatures for extended periods of time. The product does not require refrigeration and does not alter urinary pH. It also eliminates or reduces the primary causes of analyt...
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Fiber Optic Device for Sensing the Presence of Gas

Technology Description A fiber-optic device for sensing the presence of a gas in an environment is provided. The device comprises a light source for directing a light beam to a layer system having a first surface and a second surface opposite the first surface. The first surface is exposable to the ...
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Humanized Model for Spontaneous Autoimmune Myocarditis

Description: Myocarditis is a major cause of sudden death in children and young adults and is often a precursor of dilated cardiomyopathy, a common indication for cardiac transplantation. Myocarditis presents a challenging clinical problem because it is hard to diagnose and the treatment optio...
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Mouse Obesity Model with Modified Leptin Receptor

Description: The hormone leptin regulates food intake, metabolic rate and endocrine function. Disruption of leptin or its receptor molecule abolishes normal regulatory mechanisms, leading to obesity and endocrine dysfunction. The leptin receptor activates certain signal transduction pathways t...
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Insulin Receptor Substrate Knockout Mice

Description: The IRS proteins are the downstream substrates of the insulin receptor in the early steps of the signal transduction pathways triggered by insulin’s binding to its receptor. Insulin Receptor Substrate-1 (IRS-1) is a substrate for tyrosine phosphorylation by the activated insulin r...
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MCK Cre Mice

Description: This technology is an improvement to the cre-lox system for making targeted gene knockouts in mice. Clinical & Commercial Utility: The available technology features a line of mice harboring the Cre DNA recominbase gene under the control of the muscle creatine ...
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Insulin Receptor Knockout Mice

Description: The Insulin/IGF family of ligands and receptors controls mammalian growth, metabolism and reproduction, and insulin signaling at the insulin receptor is implicated in important signal transduction pathways. Interactions at this receptor can either amplify, diversify or terminate i...
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Melanocyte Concentrating Hormone Knockout Mice.

Description: Melanocyte concentrating hormone (MCH) is a cyclic peptide found in fish and mammals. Although involved in regulation of color change in fish, it is localized in the ventral aspect of the Zona Incerta and the lateral hypothalamus in mammals, and was suspected to play a role in com...
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Diagnosing and Treating Retinal Vascular Permeability

Description: Diabetic retinopathy (DR) is the leading cause of vision loss in working adults. Although its incidence and progression can be reduced by intensive glycemic and blood pressure control, nearly all patients with type 1 diabetes mellitus and over 60% of those with type 2 diabetes eve...
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Markers for Pancreatic Cancer and Cell Growth

Description: Pancreatic cancer has one of the highest mortality rates of any malignancy, and the 5-year-survival rate of patients is 4%. Approximately 28,000 patients with pancreatic cancer are diagnosed each year, and nearly all of these patients will die of their disease. The poor prognosis ...
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Methods of Diagnosing Cardiovascular Disease

Cardiovascular diseases like atherosclerosis are major causes of mortality and often occur as a complication of diabetes. Vascular dysfunction and atherosclerosis parallel the progression of diabetes and may be accelerated by factors such as hyperglycemia in individuals whose disease is poorly contr...
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Diagnosing and Treating Diabetic Retinopathy

Description: Diabetic retinopathy (DR) is the leading cause of vision loss in working adults. Although its incidence and progression can be reduced by intensive glycemic and blood pressure control, nearly all patients with type 1 diabetes mellitus and over 60% of those with type 2 diabetes eve...
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Methods of Diagnosing Cardiovascular Disease

Cardiovascular diseases like atherosclerosis are major causes of mortality and often occur as a complication of diabetes. Vascular dysfunction and atherosclerosis parallel the progression of diabetes and may be accelerated by factors such as hyperglycemia in individuals whose disease is poorly contr...
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Methods of Diagnosing Renal Disease

Description: Diabetic kidney disease, also known as diabetic nephropathy, will develop in 25-40% of individuals with Type 1 diabetes mellitus, often leading to early death. The development of diabetic nephropathy generally consists of progression from normoalbuminuria (normal Urinary Albumin E...
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Retinal Imaging System

Description: The invention overcomes certain problems inherent in traditional systems for retinal imaging through pupils that have not undergone pharmacological dilation (mydriasis). This is of particular importance in teleophthalmology, where pupil dilation can be a barrier for retinal eye e...
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Predictors of Renal Disease

Description: Diabetic kidney disease, also known as diabetic nephropathy, is an important cause of excess morbidity and premature mortality in individuals with Type 1 diabetes mellitus, 25% to 40% of whom will ultimately develop diabetic nephropathy. The most serious long-term effect of diabet...
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Type 2 Diabetes Mellitus Gene

Description: Type 2 diabetes mellitus is a highly prevalent metabolic disease characterized by hyperglycemia (high blood sugar) as a result of defective insulin action which manifests as insulin resistance, defective insulin secretion, or both. Due to the severity of some of its complications,...
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Protein Kinase C Monocyte Assay

Description: Recent studies have shown that hyperglycemia induces de novo diacylglycerol synthesis and activates Protein Kinase C (PKC), which leads to many kinds of vascular abnormalities (e.g. abnormalities of the retina or cardiovascular tissues). A means to measure PKC activity in vascular...
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Repeat Polymorphism Gene and Uses Thereof

Description: This invention is based on the finding that there is a link between risk for non-insulin-dependent diabetes mellitus (NIDDM) and frataxin, a gene relating to an ataxia disorder. This disorder is caused by a long GAA expansion in this gene, creating a defective protein. However, pa...
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Antigen Associated with Type I Diabetes Mellitus

Description: This invention relates to a protein, designated PM-1, that is expressed in human pancreatic islet cells. Autoantibodies to this protein have been found in serum of some prediabetic individuals who later developed diabetes, while such autoantibodies have not been found in serum of ...
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Diabetogene RAD

Description: This invention relates to a protein whose expression is correlated with certain diabetes disease states, and may therefore play a key role in the etiology of the disease, or may be a marker that is symptomatic of certain forms of diabetes. The Rad gene encodes a novel member of th...
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Improving Glycemic Control

Description: In differential gene expression studies of human tissue, the inventors have found that expression of genes regulated by the transcription factor SRF (serum response factor) is increased in individuals with type 2 diabetes. SRF is a highly conserved transcription factor that binds ...
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ARNT2: a Novel Target for Diabetes

Description: The invention is based on the discovery of new targets not previously known to be linked to diabetes. Microarray analysis of human pancreatic islets from people with Type 2 diabetes compared to controls with normal glucose tolerance showed that the transcription factor aryl hydro...
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ARNT: a Novel Target for Treatment of Diabetes

Description: The invention is based on the discovery of a new target, not previously known to be linked to diabetes. Microarray analysis of human pancreatic islets from people with Type 2 diabetes compared to controls with normal glucose tolerance showed that the transcription factor aryl hydr...
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SKN-1 and Oxidative Stress Resistance

Description: The transcription factor SKN-1 specifies formation of the feeding and digestive system during early stages of C. elegans embryogenesis. The inventor and his colleagues have shown that in larvae and adults SKN-1 regulates the Phase 2 detoxification response, a conserved defense aga...
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Insulin Related Transcription Factor

Description: The invention pertains to the identification and cloning of the gene encoding a previously-unknown beta-cell specific transcription factor controlling insulin gene expression. There are known to be at least three critical enhancer elements that regulate expression of the gene enco...
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Methods of Modulating Angiogenesis

Description: The invention is based on the finding that the delta isoform of Protein Kinase C can modulate pathways leading to angiogenesis or cell growth. Specifically, PKC-delta was found to regulate endothelial cell differentiation into tubes. Agonists of PKC-delta can be used to promote tu...
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Methods for Identifying Compounds for Treatment of Insulin Resistance

Description: This invention arises from the discovery that aspirin’s effect on insulin metabolism is a result of its action against the IKK-beta kinase pathway. IKK-beta activation causes insulin resistance under conditions of obesity, high fat diet and lipid infusion. Aspirin (salicylate) inh...
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Diabetogene RAD

Description: This invention relates to a protein whose expression is correlated with certain diabetes disease states, and may therefore play a key role in the etiology of the disease, or may be a marker that is symptomatic of certain forms of diabetes. The Rad gene encodes a novel member of th...
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Insulin Receptor Substrate Portfolio

This portfolio of issued patents covers several proteins (and the genes encoding them) that are the downstream substrates of the insulin receptor in the early steps of the signal transduction pathways triggered by insulin’s binding to its receptor. Patent No. 5,260,200 covers DNA encoding the IRS-1 ...
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Insulin Receptor Substrate Knockout Mice

Description: The IRS proteins are the downstream substrates of the insulin receptor in the early steps of the signal transduction pathways triggered by insulin’s binding to its receptor. Insulin Receptor Substrate-1 (IRS-1) is a substrate for tyrosine phosphorylation by the activated insulin r...
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Treatment of Metabolic Disorders with Salicylates

Description: Inflammation participates in the pathogenesis of insulin resistance, type 2 diabetes and cardiovascular disease, and weight gain and obesity are known to be accompanied by activation of at least two inflammatory pathways in adipose tissue and liver: the JNK pathway and the NF-êB p...
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Obesity and Body Fat Distribution

Description: Obesity is an epidemic health problem worldwide that impacts on the risk and prognosis of many diseases, including diabetes, cardiovascular disease, hyperlipidemia, and cancer. However, not all obese patients have the same risk of developing these disorders. Individuals with perip...
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Methods and Compositions for Inducing Brown Adipogenesis

Description: The most common fat cells are white adipose tissue (WAT) cells, which have a thin ring of cytoplasm surrounding a lipid or fat droplet. WAT is found underneath the skin and provides heat insulation, cushioning against shock and jarring, and energy reserves. An average lean person ...
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Methods and Compositions for Modulating Necdin Function

Description: The most common fat cells are white adipose tissue (WAT) cells, which have a thin ring of cytoplasm surrounding a lipid or fat droplet. WAT is found underneath the skin and provides heat insulation, cushioning against shock and jarring, and energy reserves. An average lean person ...
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Methods of Diagnosis and Treatment of Metabolic Disorders

Description: The invention is based on the discovery that two proteins within a specific family play key roles in the pathogenesis of metabolic disorders such as Type 2 diabetes and obesity. The family of proteins are the sirtuins, Class III histone deacetylases (HDACs) which are known to play...
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Methods and Compositions for Modulating Adipocyte Function

Description: The most common fat cells are white adipose tissue (WAT) cells, which have a thin ring of cytoplasm surrounding a lipid or fat droplet. WAT is found underneath the skin and provides heat insulation, cushioning against shock and jarring, and energy reserves. An average lean person ...
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Regulation of Eating Behavior

Description: Melanin concentrating hormone (MCH) is a cyclic peptide found in fish and mammals. Although involved in regulation of color change in fish, it is localized in the ventral aspect of the Zona Incerta and the lateral hypothalamus in mammals, and was suspected to play a role in comple...
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Mouse Obesity Model with Modified Leptin Receptor

Description: The hormone leptin regulates food intake, metabolic rate and endocrine function. Disruption of leptin or its receptor molecule abolishes normal regulatory mechanisms, leading to obesity and endocrine dysfunction. The leptin receptor activates certain signal transduction pathways t...
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Melanocyte Concentrating Hormone Knockout Mice.

Description: Melanocyte concentrating hormone (MCH) is a cyclic peptide found in fish and mammals. Although involved in regulation of color change in fish, it is localized in the ventral aspect of the Zona Incerta and the lateral hypothalamus in mammals, and was suspected to play a role in com...
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Compositions and Methods for Treating Diabetic Eye Disease

Description: Diabetic retinopathy (DR) is the leading cause of vision loss in working adults. Nearly all patients with type 1 diabetes mellitus and over 60% of those with type 2 diabetes eventually develop retinal microvascular abnormalities, and 20% to 30% of these patients advance to active...
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Diagnosing and Treating Retinal Vascular Permeability

Description: Diabetic retinopathy (DR) is the leading cause of vision loss in working adults. Although its incidence and progression can be reduced by intensive glycemic and blood pressure control, nearly all patients with type 1 diabetes mellitus and over 60% of those with type 2 diabetes eve...
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Methods for Treatment of Rheumatoid Arthritis

Description: Rheumatoid arthritis affects approximately 1% of the world’s population, and is a significant cause of morbidity. Current therapies for rheumatoid arthritis are based on suppressing the immune system, either by interference with the function of lymphocytes or cytokines. However, u...
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Treatment of Cardiovascular Disorders with Salicylates

Description: Inflammation participates in the pathogenesis of insulin resistance, type 2 diabetes and cardiovascular disease, and weight gain and obesity are known to be accompanied by activation of at least two inflammatory pathways in adipose tissue and liver: the JNK pathway and the NF-êB p...
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Enhancing Stem Cell Mobilization

Description: This invention provides a potentially novel approach to enhancing the efficiency of stem cell mobilization, to improve the effectiveness of stem cell transplantation therapies. Hematopoietic stem cells (HSCs) can functionally regenerate an ablated hematopoietic system, and bone ma...
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Diagnosing and Treating Diabetic Retinopathy

Description: Diabetic retinopathy (DR) is the leading cause of vision loss in working adults. Although its incidence and progression can be reduced by intensive glycemic and blood pressure control, nearly all patients with type 1 diabetes mellitus and over 60% of those with type 2 diabetes eve...
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Methods of Modulating Angiogenesis

Description: The invention is based on the finding that the delta isoform of Protein Kinase C can modulate pathways leading to angiogenesis or cell growth. Specifically, PKC-delta was found to regulate endothelial cell differentiation into tubes. Agonists of PKC-delta can be used to promote t...
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Methods of Modulating Fibrosis

Description: The invention features a novel approach to the modulation of the cellular pathways leading to fibrosis and extracellular matrix deposition. Connective tissue growth factor (CTGF) is known to be a potent activator of fibrosis, angiogenesis and extracellular matrix production. The i...
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Treatment of Permeability Failure

Description: Peritoneal dialysis is used to treat patients having renal failure. The dialysis fluid used in such treatment contains very high levels of glucose, in order to cause the osmotic extraction of toxins from the blood; however, these levels of glucose appear to damage the cells lining...
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Diabetogene RAD

Description: This invention relates to a protein whose expression is correlated with certain diabetes disease states, and may therefore play a key role in the etiology of the disease, or may be a marker that is symptomatic of certain forms of diabetes. The Rad gene encodes a novel member of th...
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Humanized Model for Spontaneous Autoimmune Myocarditis

Description: Myocarditis is a major cause of sudden death in children and young adults and is often a precursor of dilated cardiomyopathy, a common indication for cardiac transplantation. Myocarditis presents a challenging clinical problem because it is hard to diagnose and the treatment optio...
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Methods of Generating Insulin-Producing Cells

Description: A promising avenue of investigation for treatment of diabetes is that of islet cell transplantation. A variety of strategies are under investigation for the introduction into diabetic patients of functioning pancreatic islet cells, which can produce insulin and overcome the diabet...
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Encapsulated Pancreatic Cell Islet Products

Description: The efficacy of islet cell transplantation as a therapeutic strategy for diabetes has been demonstrated in humans by the Edmonton Protocol, but a number of obstacles remain for wide scale application. Problems encountered to date include the need for patients to permanently take i...
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Beta Cell Growth and Differentiation

Description: Significant efforts are currently being directed at the regeneration of functional pancreatic islets from beta-cells, as a possible treatment for Type 1 diabetes. However, the factors that stimulate the growth of beta-cells are not yet well understood. The basis for this invention...
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Methods of Modulating Beta-Cell Growth and Function

Description: The invention is based on the discovery that melanin concentrating hormone (MCH), a naturally-occurring peptide hormone known to be involved in feeding behavior and certain neurological functions, can also modulate pancreatic endocrine function and/or growth. The inventors have d...
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Insulin Related Transcription Factor

Description: The invention pertains to the identification and cloning of the gene encoding a previously-unknown beta-cell specific transcription factor controlling insulin gene expression. There are known to be at least three critical enhancer elements that regulate expression of the gene enco...
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Method of Making Pancreatic Islet Cells

Description: A major, very promising avenue of investigation for treatment of diabetes is that of islet cell transplantation. A variety of strategies are under investigation for the introduction into diabetic patients of functioning pancreatic islet cells, which can produce insulin and overcom...
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Immunologically Privileged Cells and Uses Thereof

Description: A major, very promising avenue of investigation for treatment of diabetes is that of islet cell transplantation. A variety of strategies are under investigation for the introduction into diabetic patients of functioning pancreatic islet cells, which can produce insulin and overcom...
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Improving Glycemic Control

Description: In differential gene expression studies of human tissue, the inventors have found that expression of genes regulated by the transcription factor SRF (serum response factor) is increased in individuals with type 2 diabetes. SRF is a highly conserved transcription factor that binds ...
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ARNT2: a Novel Target for Diabetes

Description: The invention is based on the discovery of new targets not previously known to be linked to diabetes. Microarray analysis of human pancreatic islets from people with Type 2 diabetes compared to controls with normal glucose tolerance showed that the transcription factor aryl hydroc...
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Treatment of Metabolic Disorders with Salicylates

Description: Inflammation participates in the pathogenesis of insulin resistance, type 2 diabetes and cardiovascular disease, and weight gain and obesity are known to be accompanied by activation of at least two inflammatory pathways in adipose tissue and liver: the JNK pathway and the NF-êB p...
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Methods of Diagnosis and Treatment of Metabolic Disorders

Description: The invention is based on the discovery that two proteins within a specific family play key roles in the pathogenesis of metabolic disorders such as Type 2 diabetes and obesity. The family of proteins are the sirtuins, Class III histone deacetylases (HDACs) which are known to play...
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ARNT: a Novel Target for Treatment of Diabetes

Description: The invention is based on the discovery of a new target, not previously known to be linked to diabetes. Microarray analysis of human pancreatic islets from people with Type 2 diabetes compared to controls with normal glucose tolerance showed that the transcription factor aryl hydr...
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Methods of Treating or Preventing Autoimmune Conditions

Description: The innate immune system is the first line of host defense against pathogens. Innate immune cells, such as dendritic cells and macrophages, are first activated and subsequently trigger the generation of optimal adaptive immune responses. Although these cells lack the highly specif...
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Type 2 Diabetes Mellitus Gene

Description: Type 2 diabetes mellitus is a highly prevalent metabolic disease characterized by hyperglycemia (high blood sugar) as a result of defective insulin action which manifests as insulin resistance, defective insulin secretion, or both. Due to the severity of some of its complications,...
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Methods for Identifying Compounds for Treatment of Insulin Resistance

Description: This invention arises from the discovery that aspirin’s effect on insulin metabolism is a result of its action against the IKK-beta kinase pathway. IKK-beta activation causes insulin resistance under conditions of obesity, high fat diet and lipid infusion. Aspirin (salicylate) inh...
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Antigen Associated with Type I Diabetes Mellitus

This invention relates to a protein, designated PM-1, that is expressed in human pancreatic islet cells. Autoantibodies to this protein have been found in serum of some prediabetic individuals who later developed diabetes, while such autoantibodies have not been found in serum of nondiabetic individ...
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Regional Chemotherapy with 4-Hydroperoxycyclophosphamide (Intrathecal Administration)

A method of treating human tumors is provided in which tumors are regionally treated with a cytolytic, pre-activated, bifunctional alkylating agent, namely 4-hydroperoxycyclophosphamide. The treatment is effective against a variety of tumor types within the central nervous systems. Cyclophosphamide,...
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Establishment of a Human Cerebral CortexCell Line

This invention consists of a continuous, non-malignant, neuronal cell line, the cells of which: a) in the undifferentiated form are essentially free of branched process; b) stain positively for neurofilament protein and neurotransmitters; c) do not stain positively for glial fibrillary acidic protei...
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MIG2

A new member of the chemokine family of cytokines has been identified. These chemokines are produced by interferon-gamma stimulated monocytes. Both the human (HuMig) and marine (MuMig) genes have been identified and cloned. These proteins are members of the platelet factor 4/IL-8 cytokine family. Li...
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Primary Culture of Olfactory Neurons

Abstract (Set) The instant primary cultures of purified olfactory neurons can be stimulated with physiological levels of odorants. The neurons of the cultures express markers characteristic of mature olfactory neurons in vivo, such as vimentin, olfactory marker protein and neuron-specific enolase ...
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Anti-viral Target for Herpes Virus

Abstract (Set) A herpes virus proteinase has been identified and cloned from cytomegalovirus. The substrate for the proteinase, which is an assembly protein precursor, has also been identified. The proteinase is useful in an assay for identifying inhibitors as potential antiviral therapies. Such in...
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Chronic Endothelial Cell Culture Under Flow

Abstract (Set) An in vitro method for producing a device coated with adherent cells by utilizing shear stress is provided. The device is useful in vivo such in prostheses such as artificial grafts....
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Molecular Cloning of Macrophage Nitric Oxide Synthase

We now report the molecular cloning of macrophage NOS. The macrophage enzyme displays 50% sequence identity to the neuronal enzyme. Like Neuronal NOS, macrophage NOS has recognition sites for FAD, FMN, and NADPH and also has a consensus calmodulin binding site. Macrophage NOS mRNA is strikingly indu...
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Karyoplasmic Interaction Selection Strategy

Abstract (Set) Karyoplasmic Interaction Selection Strategy is a system of plasmids that assays protein-protein interactions in mammalian cells on the basis of the 2-hybrid system. Description (Set) Proposed Use (Set) This system allows testing of protein-protein interactions in living cells. ...
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Use of Retinoic Acid

Proliferation of retinal pigment epithelium following surgery or trauma is prevented by contacting retinal pigment epithelium cells with a therapeutic amount of a retinoic acid receptor (RAR) agonist, preferably one with specific activity for retinoic acid receptors. Preferably the RAR agonist is al...
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Recombinationally-targeted cloning in Saccharomyces cerevisiae artificial chromosomes

Homologous recombination techniques are used to produce yeast artificial chromosomes (YAC) containing foreign target DNA by utilizing at least three DNA segments which yield the vector. Preferred embodiments allow the production of viral DNA which is infectious....
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New Uses for Camptothecin Analogs (Shapiro - joint)

Camptothecin compounds are effective inhibitors of hemoflagellate growth and are useful in treating leishmaniasis and trypanosomiasis in livestock, other domestic animals and humans....
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Reverse Two Hybrid Systems

Methods for identifying molecular interactions (e.g., protein/protein, protein/DNA, protein/RNA, or RNA/RNA interactions). All of the methods within the invention employ counterselection and at least two hybrid molecules. Molecules which interact reconstitute a transcription factor and direct expres...
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Glutamate Receptor Antibodies

Sub-unit specific anti-peptide antibodies which have been developed against the predicted amino acid sequences of several rat glutamate receptor CDNAs. Description (Set) Proposed Use (Set) The ability to identify these proteins in post-mortem human tissues allows examination of the level of th...
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Method of Inhibiting Parasitic Activity

A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myristic acid containing various heteroatoms, subst...
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Heart Simulation Software

The Heart Simulation 1 and Heart Simulation 2 programs provide a computer model of the electrical activity of the heart. More specifically, these programs allow for the simulation of cardiac arrhythmias and strategies for defibrillation. Heart Simulation 1 runs on a PC and is more suited for defibri...
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Narp Expression and Regulation in Brain

Abstract (Set) A novel neuronal cell growth factor, neuronal-activity regulated pentraxin or NARP and its encoding cDNA sequence is provided in this invention. Narp induces dendritic neurite outgrowth, promotes neuronal migration, may modulate intermediate early gene expression in neuronal tissue a...
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Novel Members of the Human Immunoglobulin Superfamily that Mediate the Entry of Alphaherpesviruses into Cells ( 98025/98018)

The alphaherpesvirus subfamily includes neurotropic viruses such as human HSV-1 and HSV-2 and animal viruses such as porcine pseudorabies virus (PRV) and the bovine herpesvirus BHV-1. Viral entry into cells requires specific interactions of virion glycoproteins with cell surface heparan sulfate and ...
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Chondrogenic and Osteogenic Inducing Molecule ( 98063)

A new family of polypeptides, called amelogenins, with activities similar to the bone morphogenetic protein family to potentiate tissue mineralization in vivo, has been identified and characterized. These polypeptides, which are translation products of particular gene splice variants of the amelogen...
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Localization of Major Peptide Autoepitopes for Nucleosome Specific T Cells of Systemic Lupus Erythematosus (20032/99016)

Investigators at Northwestern University have identified peptides localized to distinct regions of histone proteins that are recognized by autoimmune T-cells in Systemic Lupus Erythematosus (SLE). These peptides, when administered in a mouse model of SLE, delay onset as well as significantly decreas...
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Surface-Associated Delivery of Genes and Oligonucleotides in vivo (20071(v))

This invention describes a novel system for the controlled, efficient delivery of DNA or oligonucleotide (ON) complexes from a supporting scaffold that could be used in tissue engineering or regeneration and gene therapy. Using the proposed methods, a scaffold made of a biocompatible polymer would b...
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A New Potent Irreversible Inhibitor of y-Aminobutyric Acid Aminotransferase (21058/23058)

A promising new candidate inhibitor of the enzyme gamma-aminobutyric acid aminotransferase, critical to central nervous system disorders, has been prepared. Therapeutic potential in the treatment of epilepsy, drug addiction, pain control and neurological disorders is indicated. ADVANTAGES: In vit...
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Mammalian Sterol Synthesis as a Target for Chemotherapy Against Bacteria (21061)

Recent discoveries at Northwestern University offer the opportunity to use well characterized drugs, known as statins, for a new much needed use, as antibacterial/antibiotic compounds. Thus, the present invention focuses on the use of statins as anti-bacterial drugs. Shown below is a graph demonstra...
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Cell Line Overexpressing DNA Methyltransferase

Abstract (Set) Abnormal regional increases in DNA methylation, which have potential for causing gene inactivation and chromosomal instability, are consistently found in immortalized and tumorigenic cells. Increased DNA methyltransferase activity, which is also a characteristic of such cells, is a c...
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Floxed GFRalpha-1 Mouse

Abstract (Set) Scientists at JHU have created a mouse that harbors mutations allowing for the conditional inactivation of the GFRalpha-1 protein through the use of Cre mouse lines. Description (Set) Proposed Use (Set) These mouse lines can be used to investigate the role of GDNF in neural cell...
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Floxed Ret Mouse

Abstract (Set) Scientists at JHU have created a mouse that harbors mutations allowing for the conditional inactivation of the Ret protein through the use of Cre mouse lines. Description (Set) Proposed Use (Set) These mouse lines can be used to investigate the role of GDNF in neural cell develo...
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Biomarkers for Chemo-resistance in Ovarian Cancer

Abstract (Set) Ovarian cancer is the most lethal gynecologic malignancy in the US. Although it is initially very responsive (80%) to cisplatin-based chemotherapy, 75% of patients easily develop cisplatin resistance and relapse within 2 years of primary therapy. The progression of cisplatin-resistan...
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The Preparation and Application of an Adenovirus Construct to Treat Human Cancers

Abstract (Set) JHU scientists have identified a peptide derived from p55PIK, a PI 3-kinse regulatory subunit, which can effectively block the cell cycle progression of a variety of cancers. To deliver the peptide to cells, they made a replication-deficient adenovirus construct expressing the peptid...
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Administration of DNA Vaccines with DNA Encoding Ii-PADRE Generates Potent PADRE-specific CD4+ T-cell Immune Responses and Enhances Vaccine Potency

Abstract (Set) Various strategies have been developed for enhancing DNA vaccine potency by modifying the properties of Antigen Presenting Cells (APCs). These strategies include increasing the number of antigen-expressing Dendritic Cells (DCs); improving antigen expression, processing, and presentat...
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Methods and Compositions for Inhibiting Angiogenesis (21064/21013/20001/96047)

Investigators at Northwestern University have discovered that pigment epithelium derived factor (PEDF), a glycoprotein secreted by a variety of normal cells, is an unusually potent endogenous inhibitor of angiogenesis, and is particularly active in the eye, the prostate, the pancreas and the kidney...
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Reactivation of Mutant p53 with a New Class of Small Molecules (23079)

Novel molecules, effective at inducing apoptosis by reactivating mutant p53, have recently been synthesized by Daniel Appella et. al. These compounds facilitate p53 protein binding to DNA and activate apoptosis in transformed cells. BACKGROUND: In healthy cells, p53 controls the integrity of cel...
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Biodegradable, Drug-Releasing Tubes for Tissue Engineering and Regeneration (23091)

Biodegradable drug-releasing conduits for applications in tissue engineering and neuronal regeneration. These conduits are capable of delivering DNA, protein, and/or small molecules. Significance: Investigators at Northwestern have designed biodegradable nerve guidance conduits or bridges possess...
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Cell-specific Molecule and Method for Importing DNA into pulmonary epithelial cell nuclei (24002)

A short DNA sequence that can be placed into any gene therapy vector for efficient targeted expression in pulmonary epithelial cells. This invention has applications in the treatment of a number of pulmonary diseases and disorders such as cystic fibrosis, acute respiratory distress syndrome, and pu...
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Cyclic Peptides and Cyclic Depsipeptides with Antitumor Activity (24095/23053/22081)

A novel family of peptide compounds with enhanced anti-proliferative activity has been synthesized at Northwestern University. These peptide inhibitors have anticancer activity exceeding that of two known growth inhibitors. This newly identified family of compounds has been tested in human prostate...
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Modulation of Immune Function by the Targeted Enhancement of CD154 Trimer Stability (25008)

Two lead compounds have been identified that can enhance immune function in vivo through a novel mechanism of stabilizing the CD154 trimer on the surface of activated T cells. ADVANTAGES: The compounds are the first demonstrated to enhance immune function in this way. The molecules can be applied...
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Arsenic Encapsulation and Triggered Release for Cancer Treatment (25053)

Novel procedures and compositions for the encapsulation and delivery of arsenic drugs. SIGNIFICANCE: Despite its long history and excellent therapy, arsenic compounds have a variety of widely appreciated toxic side effects, which currently limit their application. The invention presented here pr...
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Protein Kinase Targeted Therapeutics (26087)

A validated novel compound and medicinal chemistry refinement for bioavailable small molecule inhibitors of protein kinases or protein kinase-mediated cellular stress response pathways. ADVANTAGES: A small molecule p38α MAPK inhibitor presents significant therapy potential for neurodegenerative ...
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Myosin Light Chain Kinase Inhibitor Compounds, Compositions and Related Methods of Use (26088)

A new class of small molecule therapeutic candidates with potential to address areas of disease and injury relevant to tissue barrier dysfunction, such as sepsis, lung injury, microvascular leak, Crohn's disease and related disorders, as well as multi-organ failure. ADVANTAGES: A small molecule ...
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NOS Inhibitors for Treatment of Motor Deficit Disorder (26093)

Northwestern scientists have prepared compositions that are powerful and highly selective for inhibiting neuronal NOS activity in the fetal brain and protecting fetal rabbit kits from HI-induced symptoms of cerebral palsy. The compositions appear to be nontoxic and show no detrimental cardiovascular...
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Improving Islet Survival by Encapsulation in Hydrogels Modified with Anti-Apoptotic Peptides (27055)

Novel in-situ hydrogels enabling islet cell encapsulation, stabilization and protection against cytokine induced cell apoptosis for improved tissue graft survival in transplantation applications. ADVANTAGES: A new and potentially general approach of encapsulating and maintaining transplant tiss...
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DNA-binding Self-assembling Peptide Amphiphile System for the Transfection of Cellular Aggregates (27116)

A self-assembling peptide system utilizing a bioactive sequence which significantly enhances transfection efficiency. ADVANTAGES: A self-assembling peptide system able to transfect aggregates of cells more completely and with higher efficiency than present day commercial reagents. The system app...
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Flufenamic Acid for the Treatment of Chronic Pain (27153)

Oral administration of flufenamic acid (FA) has a potent analgesic effect that can be exploited for the treatment of chronic pain. Chronic pain is an invalidating condition affecting a large number of people and no pharmacologic treatment has proven completely effective so far. SIGNIFICANCE: Pa...
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Layered Islet Delivery Scaffold (27154, 27090)

Northwestern University has designed a multilayered functional delivery system for islet cell transplantation. The layered polymer advances the opportunity for glycemic control in diabetic patients through tissue engineering. Key Design Innovations: Layered design isolates protein/gene deliv...
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Administration of DNA Vaccines with DNA Encoding Ii-PADRE Generates Potent PADRE-specific CD4+ T-cell Immune Responses and Enhances Vaccine Potency

Abstract (Set) Various strategies have been developed for enhancing DNA vaccine potency by modifying the properties of Antigen Presenting Cells (APCs). These strategies include increasing the number of antigen-expressing Dendritic Cells (DCs); improving antigen expression, processing, and presentat...
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Administration of DNA Vaccines with DNA Encoding Ii-PADRE Generates Potent PADRE-specific CD4+ T-cell Immune Responses and Enhances Vaccine Potency

Abstract (Set) Various strategies have been developed for enhancing DNA vaccine potency by modifying the properties of Antigen Presenting Cells (APCs). These strategies include increasing the number of antigen-expressing Dendritic Cells (DCs); improving antigen expression, processing, and presentat...
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DNA-binding Self-assembling Peptide Amphiphile System for the Transfection of Cellular Aggregates (27116)

A self-assembling peptide system utilizing a bioactive sequence which significantly enhances transfection efficiency. ADVANTAGES: A self-assembling peptide system able to transfect aggregates of cells more completely and with higher efficiency than present day commercial reagents. The system app...
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Control of Human Mesothelin-expressing Tumors By DNA Vaccines

Abstract (Set) Mesothelin has been implicated as a potential ideal target antigen for the development of antigen-specific cancer immunotherapy for the control of mesothelin-expressing cancers such as ovarian cancer, mesothelioma, and pancreatic adenocarcinoma. JHU researchers utilized a DNA vaccine...
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Control of Human Mesothelin-expressing Tumors By DNA Vaccines

Abstract (Set) Mesothelin has been implicated as a potential ideal target antigen for the development of antigen-specific cancer immunotherapy for the control of mesothelin-expressing cancers such as ovarian cancer, mesothelioma, and pancreatic adenocarcinoma. JHU researchers utilized a DNA vaccine...
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Control of Human Mesothelin-expressing Tumors By DNA Vaccines

Abstract (Set) Mesothelin has been implicated as a potential ideal target antigen for the development of antigen-specific cancer immunotherapy for the control of mesothelin-expressing cancers such as ovarian cancer, mesothelioma, and pancreatic adenocarcinoma. JHU researchers utilized a DNA vaccine...
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Generation and Characterization of a Preventive and Therapeutic HPV DNA Vaccine

Abstract (Set) Cervical cancer is one of the most common cancers in women worldwide. Persistent infection with human papillomavirus (HPV) is considered to be the etiological factor for cervical cancer. Therefore, an effective vaccine against HPV infections may lead to the control of cervical cancer...
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Selective, Facile, Quantitative Detection of 2'-deoxyguanosine intermediates

Abstract (Set) A variety of structural modifications (lesions) are produced in DNA when the biopolymer is exposed to oxidative stress. Lesions can be genotoxic and/or cytotoxic, and are useful biomarkers. Selective, quantitative detection of lesions is useful for rapidly determining the effects of ...
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Serial Assessment of Human Tumor Burdens in Mice by the Analysis of Circulating DNA

Abstract (Set) It is generally agreed that internal human xenografts provide the best animal models to study the microenvironments and metastatic processes occurring in human cancers. However, the use of such models is hampered by the logistical difficulties of reproducibly and simply assessing tum...
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PIK3CA Exon 9 and Exon 20 Knock in Cells

Abstract (Set) PIK3CA exon 9 and exon 20 knock in cells within the MCF-10A human breast epithelial cell line. Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for novel molecules that target the PIK3CA pathway in human cancer cells or to c...
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Estrogen Receptor in Knock out (ERIK) Cells

Abstract (Set) Receptor positive non-tumorigenic human breast epithelial cell line derived from the commercially available MCF-10A human breast epithelial cell line with the p21 gene somatically deleted. Description (Set) Proposed Use (Set) The cell lines described in this invention can be us...
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K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells

Abstract (Set) Single oncogenic point mutation in codon 12 of K-Ras was "knocked in" to the commercially available MCF-l0A cell line and two other hTERT immortalized human breast epithelial cell lines. Description (Set) Proposed Use (Set) The cell lines described in this invention can be used...
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Specific Delivery of a Tumor-ablating Agent by a DECApeptide to Colon and Esophageal Cancer Cell Lines as a Therapeutic Treatment

Abstract (Set) Targeted tumor therapy is commonly based on the use of antibodies directed against a specific molecule, and tagged with a tumor ablating material to deliver therapy to the target cell. Now, scientists at JHU have discovered a new method of targeting therapy to tumor cells, by using a...
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Novel Anticancer Drug Leads

Abstract (Set) A novel target for cancer therapy has been discovered by JHU scientists. The drug azalanstat appears to act as an inhibitor and may be used to develop lead compounds for novel angiogenesis inhibitors. In a series of experiments, where azalanstat and small hairpin RNAs were used to kn...
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A Biotin-labeled Antibody for the Pre-clinical Diagnosis of Alzheimer?s Disease

Abstract (Set) Amyloid beta (A?is the main constituent of amyloid plaques in the brains of Alzheimer's disease patients. Research to determine the dynamic equilibrium of A?n the brain and blood is essential to understanding the pathogenesis of Alzheimer?s disease. Previous studies have shown that a...
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A Small Molecule Inhibitor of Glioblastomas

Abstract (Set) BACKGROUND: Mutations of the epidermal growth factor receptor (EGFR) are a possible molecular target for cancer therapy. EGFR is frequently amplified in glioblastomas and 30 to 40% of glioblastomas also express the deletion mutation EGFRvIII. This frequent oncogenic mutation provides...
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Breast Milk Component Provides Protection Against Acute Respiratory Diseases

Description (Set) It has long been established that breast milk provides a protective role against acute respiratory disease. Scientists at Johns Hopkins University have identified a protective substance in breast milk that significantly decreases the risk of acute lung disease. The differences tha...
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Automate Image Analyses for Magnetic Resonance Imaging

Abstract (Set) In this disclosure, we describe methods to perform automated analyses of MRI data. We propose automated tissue segmentation and subsequent morphological and photometrical analyses. The main goal is computer assisted diagnosis (CAD) but the technique can also be applied to a wide rang...
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Variant Gene Increases Risk of Type 2 Diabetes

Description (Set) Type II Diabetes Mellitus (T2DM) represents a major global health challenge with over 170 million people affected worldwide. It is a condition in which the body fails to properly use insulin and additionally, is generally combined with relative insulin deficiency. Scientists have ...
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Head & Neck Squamous Cell Carcinoma an Non-Small Cell Lung Cancer Prognostics and Diagnostics

Abstract (Set) Epigenetic changes have been implicated in the pathogenesis of solid tumors and almost all types of cancers primarily via abnormal promoter hypermethylation and silencing of tumor suppressor gene expression. Epigenetic changes are changes in an organism brought about by alterations i...
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Seventy Two Gene Model for 8 Thyroid Tumor Types

Description (Set) Thyroid cancer represents 90% of all neuroendocrine malignancies with an estimated annual incidence of 122,800 cases worldwide. Currently, the most useful tool for the diagnosis of thyroid cancer is Fine-needle aspiration biopsy (FNA). This current method is extremely useful when ...
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Twist overexpression promotes chromosomal instability in the breast cancer cell line MCF-7

Description (Set) Chromosomal instability, the continuous formation of novel chromosome mutations at a rate higher than in normal cells, is a defining characteristic of most human cancers. Twist is a basic helix-loop-helix transcription factor that is a major regulator of mesenchymal phenotypes. JH...
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Cell Lines with Targeted Deletions of p53

Abstract (Set) Cell lines with deletions of p53 can be used for testing the specificity of drugs that target the p53 pathway. This pathway is inactivated in multiple forms of tumors. The cells lines include the following: ? HCT116 R248W/- ? DLD1 R248W ? DLD1 -/- ? RKO -/- ? SW48 -/-...
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Targeted Mutagenesis of the Zebrafish Genome Through Manipulation of Helicase Activity

Description (Set) Helicase enzymes are important enzymes functioning in DNA replication, repair, recombination, and RNA transcription. RecQ helicases are a family of helicases that act to suppress homologous recombination at specific junctions. Despite the many advantages of the zebrafish as an exp...
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Detection of Prostate Cancer Proteins in Serum for Cancer Diagnosis with a Blood Test

Abstract (Set) There is a crucial need of discovering novel biomarkers to improve the specificity of clinical diagnosis for prostate cancer. To achieve this goal, quantitative proteomic profiling is required that can be applied in a high-throughput fashion. With the rapid developments of glycopepti...
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Processing of Optical Coherence Tomography Signals - for both Medical and Non-Medical Applications (22044)

Optical Coherence Tomography (OCT) is the optical analog of ultrasound tomography. In OCT, an optical wave is launched into a tissue sample where it is reflected off of interfaces and where optical energy returns to a detector. These interfaces are located where the speed of light, i.e. the inde...
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Use of Transcranial Magnetic Stimulation (TMS) to Treat Cerebral Palsy.

Description (Set) Cerebral palsy is manifested in a wide range of muscle dysfunctions which can have a severe impact on the quality of life of the patient. Using an innovative imaging technique, JHU scientists have observed unexpected and surprising pathologies in the brain of the cerebral palsy pa...
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Radiolabeled Inhibitors for Prostate Cancer Imaging & Therapeutics

Abstract (Set) Prostate-specific membrane antigen (PSMA) is a cell surface protein that is over expressed in prostate cancer, including hormone-refractory and metastatic disease. Successful imaging of xenografts that express the prostate-specific membrane antigen (PSMA) using small animal PET and P...
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Functional Isolation of the Low-oxygenic Niche Derived Primitive Hematopoietic Stem Cells By Differential ROS Activity

Abstract (Set) A low-oxygenic niche in bone marrow limits reactive oxygen species (ROS) production, thus providing long-term protection for hematopoietic stem cells (HSCs) from ROS stress. Although many approaches have been used to enrich HSCs, none have been designed to isolate primitive HSCs loca...
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Diagnosis, Prevention and Treatment of Eye Injury and Infection

Abstract (Set) According to the World Health Organization, cataracts are the leading cause of blindness in the world. Approximately 10 million cataract operations are performed each year in the world. By the year 2020 the number of blind people over 60 years of age will likely reach 54 million worl...
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PET32a O-GlcNAcase-thioredoxin Expression Vector

Abstract (Set) Expression and Purification of Recombinant and Endgenous 0- GlcNAcase The human O-GlcNAcase cDNA was subcloned into the commercial expression bacterial expression vector PET32a (Novagen, Madison, WI), as was the shorter splice variant (MGEA5 s), to yield fusion proteins with thioredo...
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High-speed Diode for Low-cost Organic Circuitry

Abstract (Set) The Johns Hopkins University seeks a partner to commercialize a new organic diode useful for constructing complex organic electronic circuitry. The diode utilizes polymer and inorganic oxide layers to achieve high-frequency alternating current (AC) rectification, an operational requi...
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Protein Expression Markers for the Detection of Thyroid Cancer Metastasis

Description (Set) Approximately 80% of all thyroid cancers are papillary thyroid carcinomas (PTCs). Correct staging of PTC is one of the most important parts of the work up of patients for both prediction of outcome and determination of the most appropriate treatment. PTC generally has a high cure ...
...

MKK4/MAP2K4 KO Lines for Drug Discovery

Description (Set) MKK4 (JNKK1, MAP2K4, and SEK1), a dual-specificity kinase gene on chromosome 17p11, is a tumor suppressor gene that is mutated in a subset of most tumor types. MKK4 protein is activated by several kinases, and active MKK4 cooperates with MKK7 to phosphorylate and thereby activate ...
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Facile, PCR Free Detection of DNA with Single Nucleotide Discrimination

Abstract (Set) Single nucleotide modifications in DNA have important affects on gene expression. This results in significant phenotypic effects. Mutations in genes can also result in the development of diseases, including cancer. The ability to rapidly analyze DNA sequence is useful for correlating...
...

Methods to Reduce Damage from Stroke and Other Neurological Disorders.

Description (Set) Cerebral ischemia (stoke) is an acute neurological condition that is caused by a blood clot that blocks a blood vessel in the brain, while a cerebral hemorrhage (stroke) is caused by a blood vessel that breaks and bleeds into the brain. The result of a stroke is the initiation of ...
...

Methods to Block or Reduce Damage from Stroke and Other Neurological Disorders

Description (Set) An acute neurological condition caused by blood clots that block blood vessels in the brain is cerebral ischemia (stroke) similarly; blood vessel breakage in the brain is cerebral hemorrhage (stroke). These blood vessel miscues result in the initiation of an ischemic cascade that ...
...

A Novel Method for Generating and Screening Peptides and Libraries Displayed on Adenovirus Fiber

Abstract (Set) Capsid-displayed adenoviral peptide libraries have been a significant yet unfeasible goal in biotechnology. Three barriers have made this difficult: the large size of the viral genome, the low efficiency of converting plasmid-based genomes into packaged adenovirus, and the fact that ...
...

A Novel Cystic Fibrosis Therapeutic Agent

Abstract (Set) JHU scientists found that a known drug has a novel function as a stimulator of calcium-activated Cl- channels (CaCCs) and, thus, is a potential therapeutic drug in the treatment of cystic fibrosis. Cystic fibrosis is the number one genetic killer of children and young adults in the U...
...

Candidate Proteasome Inhibitors that Prevent E6 Mediated p53 Degradation and Selectively Kill HPV+ Cervical Cancer

Abstract (Set) High-risk strains of Human papillomavirus (HPV) cause over 90% of cervical cancers. About 20 million people (men and women) are thought to have an active HPV infection at any given time. Yearly, 14,000 cases are diagnosed and 5,000 women each year die of cervical cancer in the United...
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ER alpha M4, ER alpha U4, p16 M4, p16 U5, Hin1 M1, Hin1 U2, RASSF1a M1, RASSF1a U1, RAR beta M1, RAR beta U1, Twist BM2, Twist BU5, APC M3, APC U3, Cylin D2 M1, Cyclin D2 U4, 14-3-3 M2, 14-3-3 U3, HIC

Abstract (Set) Plasmid DNAs incorporating human gene-specific promoter sequences altered by sodium bisulfite treatment. Description (Set) Proposed Use (Set) Their use includes serving as reagents, standards, or controls for assays of gene methylation (e.g. for determining Methylated or unmethy...
...

Novel Immunotherapy for Contact Dermatitis

Abstract (Set) Allergic contact dermatitis, the third most common reason for outpatient dermatology visits, is an immunological disease that gives significant influences on patient's quality of life and makes enormous economical impacts. Current therapies for contact dermatitis are largely dependen...
...

Novel Strategy to Induce Erythropoietin Production in vivo

Description (Set) Anemia is the most common disorder of the blood. For chronic anemia such as induced by renal failure and chemotherapy, administration of recombinant erythropoietin (EPO) protein exhibits powerful therapeutic effects. Unfortunately, this therapeutic efficacy is accompanied by side-...
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Mouse Model of Human Head and Neck Squamous Cell Carcinoma

Abstract (Set) Cancers of the head and neck, the majority of which arise in the squamous cells that line the mucosal surfaces in the head and neck, account for 3% of all malignancies in the United States. Human head and neck squamous cell carcinoma is a clinically aggressive tumor, and fewer than 5...
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PSMA-targeted Nanoparticles for Therapy of Prostate Cancer

Description (Set) Targeted therapy for cancer has gained considerable importance recently with various improvements not only in target identification, but also in small molecule or antibody development. It has also been demonstrated that polymeric nanoparticles can passively target tumors via the e...
...

Topical Administration of Peripherally Acting Drugs for the Treatment of Chronic Pain

Abstract (Set) Clinicians currently have few therapeutic options when it comes to treating chronic neuropathic pain. Drugs available on the market today are not effective in all patients, and often result in partial alleviation of pain. Multiple studies have shown that opioids are effective in trea...
...

The Immediate Early Gene Arc Interacts with Endocytic Machinery and Regulates the Trafficking and Function of Presenilin

Abstract (Set) These discoveries promise a novel approach to develop agents to regulate presenilin 1 (PS 1) and treat Alzheimer's Disease and age-dependent memory decline. PS 1 functions as part of the gamma secretase (protease) complex that acts on amyloid precursor protein (APP), Notch and severa...
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A "Molecular Switch" in Group 1 mGluR Signaling Relevant to Neurological and Psychiatric Diseases

Abstract (Set) Reported here is the mechanism by which group 1 metabotropic glutamate receptors (mGluR) are co-functional with dopamine receptors or growth factor receptors. This convergent signaling is central to understanding several diseases including drug addiction, inflammatory pain, schizophr...
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Use of Transcranial Magnetic Stimulation (TMS) to Treat Cerebral Palsy.

Abstract (Set) Prostate-specific membrane antigen (PSMA) is a cell surface protein that is over expressed in prostate cancer, including hormone-refractory and metastatic disease. Successful imaging of xenografts that express the prostate-specific membrane antigen (PSMA) using small animal PET and P...
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Radiolabeled Inhibitors for Prostate Cancer Imaging & Therapeutics

Abstract (Set) Prostate-specific membrane antigen (PSMA) is a cell surface protein that is over expressed in prostate cancer, including hormone-refractory and metastatic disease. Successful imaging of xenografts that express the prostate-specific membrane antigen (PSMA) using small animal PET and P...
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Functional Isolation of the Low-oxygenic Niche Derived Primitive Hematopoietic Stem Cells By Differential ROS Activity

Abstract (Set) A low-oxygenic niche in bone marrow limits reactive oxygen species (ROS) production, thus providing long-term protection for hematopoietic stem cells (HSCs) from ROS stress. Although many approaches have been used to enrich HSCs, none have been designed to isolate primitive HSCs loca...
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Diagnosis, Prevention and Treatment of Eye Injury and Infection

Abstract (Set) According to the World Health Organization, cataracts are the leading cause of blindness in the world. Approximately 10 million cataract operations are performed each year in the world. By the year 2020 the number of blind people over 60 years of age will likely reach 54 million worl...
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PET32a O-GlcNAcase-thioredoxin Expression Vector

Abstract (Set) Expression and Purification of Recombinant and Endgenous 0- GlcNAcase The human O-GlcNAcase cDNA was subcloned into the commercial expression bacterial expression vector PET32a (Novagen, Madison, WI), as was the shorter splice variant (MGEA5 s), to yield fusion proteins with thioredo...
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Protein Expression Markers for the Detection of Thyroid Cancer Metastasis

Description (Set) Approximately 80% of all thyroid cancers are papillary thyroid carcinomas (PTCs). Correct staging of PTC is one of the most important parts of the work up of patients for both prediction of outcome and determination of the most appropriate treatment. PTC generally has a high cure ...
...

Regional Chemotherapy with 4-Hydroperoxycyclophosphamide (Intrathecal Administration)

A method of treating human tumors is provided in which tumors are regionally treated with a cytolytic, pre-activated, bifunctional alkylating agent, namely 4-hydroperoxycyclophosphamide. The treatment is effective against a variety of tumor types within the central nervous systems. Cyclophosphamide,...
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Method of Retarding the Progression of Chronic Renal Failure

Progression of chronic renal failure can be retarded (slowed or arrested) by administering to humans suffering from such disorder an agent which suppresses the production of glucocorticoids in the human. The agents may be administered alone or in combination with a protein restricted and/or phosphor...
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BRCA2 KO Lines for Drug Discovery

BRACA2 is a DNA repair gene. Mutations in BRACA2 cause an inherited risk of breast, ovarian and pancreatic cancers. The cancer cell lines are engineered to lack BRACA2 and are useful screening tools for chemotherapeutic or chemopreventative agents Description (Set) Proposed Use (Set) The BRACA...
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Novel Drug Development for Cancer

vivo. Although, the BPU analogs are effective in the palliative management of a wide variety of human malignancies, their utility as chemotherapeutic agents is limited for several reasons: 1) They are almost insoluble in water; 2) they are difficult to formulate; and 3) they have relatively low bioa...
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CanScript for Gene Therapy: a DNA Enhancer Element Conveying Cancer-specific Expression to 30% of Human Malignancies

One of the major requirements for effective cancer gene therapies are DNA sequences that, when inserted into a gene-expression construct, will drive high-level gene expression exclusively in cancer cells. These sequences are termed cancer specific enhancers or promoters of gene transcription. Until...
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Novel Protein Increases Muscle Mass

Muscle mass is normally regulated by the activities of members of the transforming growth factor-B (TGF-B) superfamily, which act to limit muscle growth. Scientists at JHU have now found a protein that is capable of binding certain members of the TGF-B family and inhibiting their activities in vitr...
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Specific Absorption Rate (SAR) Dosimeter for RF Power Deposition in MRI

The present invention addresses the critical need for direct and independent SAR by providing the first dosimeter for MRI which directly measures standard average head and body SAR. The device uses a transducer placed in the scanner, comprised of induction looping a resistive load and a small MRI se...
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An Assay to Identify Novel Targets and Personalize Combination Anticancer Therapy

Scientists at JHU have developed a pharmacodiagnostic assay to identify relevant targets and direct the design of individual patient combination anticancer therapy. The assay is based on fine needle aspiration of a neoplastic lesion, exposing the acquired materials ex vivo to control media or media ...
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Serum Response Factor (SRF) Conditional Knockout Mice

Scientists at JHU have created conditional serum response factor (srf) knockout mice to investigate the plasticity of adult neurons. The mice were generated to circumvent the embryonic lethality associated with Srf null mice and allow for the ablation of Srf in a spatially- and temporally-restricted...
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Myc-repressed microRNAs as Novel Anti-cancer Therapeutic Agents

MicroRNAs (miRNAs) are 18-24 nucleotide RNA molecules that regulate the stability or translational efficiency of target mRNAs. miRNAs are frequently dysregulated in cancer cells and can act as oncogenes and tumor-suppressors. The proto-oncogene c-MYC encodes a transcription factor that regulates cel...
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A Novel Agent to Reduce the Requirement of Analgesics in Clinical Pain Management

N-methyl-d-aspartate (NMDA) receptor activation has been demonstrated to play an important role in the processing of spinal nociceptive information. Postsynaptic density protein-95 (PSD-95), a scaffolding protein, has been identified to attach NMDA receptors to internal signaling molecules at neuron...
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293 Cell Line for Flag-tagged HIMF (flag-HIMF-293)

Hypoxia-induced mitogenic factor (HIMF) is highly up regulated in the lungs as a result of hypoxia-induced pulmonary hypertension, and has proangiogenic and proinflammatory effects in the lung. As a research tool for studying the function and activity of HIMF, JHU researchers have developed a trans...
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Mutations of the Cholecystokinin Receptor Type 2 in Human Cancers

Gastrin and the cholecystokinin type B/gastrin receptor (CCKBR) have been shown to be expressed in colorectal adenocarcinoma. Colorectal adenocarcinoma is the second leading cause of cancer mortality in the United States. The CCKBR was screened for mutations in colon, lung, and breast, gastric, pan...
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Quantitative Detection of Promoter Hypermethylation as a Biomarker of Acute Kidney Injury During Transplantation

Kidney repair after injury is a recapitulation of normal morphogenesis, with similarities to malignant transformation, and aberrant promoter hypermethylation, also known as epigenetics, is a promising biomarker approach to diagnose malignancies. Therefore, JHU researchers investigated whether methyl...
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Formulation of Toll-like Receptor Ligand with Whole Cell Tumor Vaccine to Enhance Anti-tumor Responses

Established reports in literature have shown that the innate immune system can modulate immune responses against cancer. Lipopolysaccharide (LPS), a Toll-like receptor ligand 4 (TLR4), was absorbed onto whole cell tumor vaccine using a liposome formulation. The liposome reagent was titrated with LPS...
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A Functional Assay Distinguishing Pathogenic and Nonpathogenic Variant Alleles of the BRCA2 Gene

Some inherited mutations that inactivate BRCA2 and cause a high familial risk of breast, ovarian, and pancreatic cancer are common in the population. Other mutations are less frequent and referred to as Variants of Unknown Clinical Significance (VUCS). These individual gene mutations are uncharacter...
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Toxic Role of Heme Oxygenase in Hemorrhage

JHU scientists have investigated the contribution of inducible HO-1 to early brain injury produced by intracerebral hemorrhage (ICH). In vivo studies determined that after induction of ICH, HO-1 proteins are highly detectable in the peri-ICH region predominantly in microglia/macrophages and endothe...
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Development of a Combinational Paradigm Combating HIV, HIV/HSV or HIV/HPV Infections in Humans

million have been infected in the year 2006 alone. AIDS death reached 2.9 million this year which is the highest ever reported in any year. There are 40,000 new AIDS cases a year in U.S. along. The anti-HIV compounds that are currently being used to treat AIDS patients include several reverse transc...
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Biofunctional Fibers

The present invention is directed to surface functionalization of polymeric fibers. Surface biofunctionalization is achieved by covalent conjugation of biofunctional igands and/or cell growth factors that are crucial for cell attachment, proliferation and functions. Biofunctional fibers could be fab...
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Methods for Inducing Immune Tolerance By Inhibiting the Fas Pathway

Fas ligand ("FasL") is a protein with an activity to induce apoptosis of a Fas antigen ("Fas")-expressing cell. Apoptosis of the Fas antigen-expressing cells is believed to be induced by binding of FasL with Fas on the cell surface, which results in the transfer of an apoptosis signal to the cell vi...
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Derivation of Multipotent Mesenchymal Cells from Human Embryonic Stem Cells and Biomaterials-Directed in Vivo Commitment

Heterogeneous differentiation of human embryonic stem cells (hESC) limits the potential use of hESCs for cell-based therapies and studies of specific differentiation programs. Clearly, more efficient and selective methods are needed to direct the proliferation and differentiation of hES cells to pro...
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Persistence Switch Involved in Persister Formation and Tolerance to Multiple Antibiotics and Stresses, as a Drug Target for Persister Bacteria

Persister bacteria are metabolically quiescent cells that neither grow nor die in the presence of antibiotics. The biological mechanism of bacterial persistence is not fully understood but it is clear that they reduce antibiotic efficacy, which leads to millions of infectious disease deaths each yea...
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Controlled Microencapsulation of Mammalian Cells

The present invention is directed to an automated device and method to prepare polyelectrolyte microcapsules for controlled microencapsulation of mammalian cells. This device and method delivers precision control of volume of microcapsules at picoliter scale with narrow size distribution and with co...
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MKK4/MAP2K4 KO Lines for Drug Discovery

Description (Set) MKK4 (JNKK1, MAP2K4, and SEK1), a dual-specificity kinase gene on chromosome 17p11, is a tumor suppressor gene that is mutated in a subset of most tumor types. MKK4 protein is activated by several kinases, and active MKK4 cooperates with MKK7 to phosphorylate and thereby activate ...
...

Detection of Antibodies to Specific Glycans as a Novel Diagnostic Test for Autoimmune Disease

Abstract (Set) JHU scientists have identified biomarkers specific for autoimmune disease. Systemic autoimmune diseases are life- threatening, complex and can involve various organ systems including skin, joints, the renal system, the hematopoietic system, and the cardiovascular system. In autoimmun...
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Facile, PCR Free Detection of DNA with Single Nucleotide Discrimination

Abstract (Set) Single nucleotide modifications in DNA have important affects on gene expression. This results in significant phenotypic effects. Mutations in genes can also result in the development of diseases, including cancer. The ability to rapidly analyze DNA sequence is useful for correlating...
...

Methods to Block or Reduce Damage from Stroke and Other Neurological Disorders

Description (Set) An acute neurological condition caused by blood clots that block blood vessels in the brain is cerebral ischemia (stroke) similarly; blood vessel breakage in the brain is cerebral hemorrhage (stroke). These blood vessel miscues result in the initiation of an ischemic cascade that ...
...

A Novel Method for Generating and Screening Peptides and Libraries Displayed on Adenovirus Fiber

Abstract (Set) Capsid-displayed adenoviral peptide libraries have been a significant yet unfeasible goal in biotechnology. Three barriers have made this difficult: the large size of the viral genome, the low efficiency of converting plasmid-based genomes into packaged adenovirus, and the fact that ...
...

A Novel Cystic Fibrosis Therapeutic Agent

Abstract (Set) JHU scientists found that a known drug has a novel function as a stimulator of calcium-activated Cl- channels (CaCCs) and, thus, is a potential therapeutic drug in the treatment of cystic fibrosis. Cystic fibrosis is the number one genetic killer of children and young adults in the U...
...

MicroRNA Expression and Control of Stem Cell Pluripotency, Differentiation and Cellular Processes

MicroRNAs (miRNAs) are a class of short non-coding RNAs that bind to the 3' untranslated region of mRNAs and downregulate their translation to protein. MiRNAs play critical roles in many different cellular processes including metabolism, apoptosis, differentiation, and development. Researchers at J...
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Reversal of Aberrant Cancer Gene Silencing By Inhibition of SIRT1

The class III histone deactylase (HDAC), SIRT1, has cancer relevance because it regulates lifespan in multiple organisms, down-regulates p53 function through deacetylation, and is linked to polycomb gene silencing in Drosophila. JHU inventors have shown that SIRT1 localizes to promoters of several a...
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Generation of Xenografts on Mice to Tailor Anticancer Therapy from Fine Needle Aspiration Biopsies

Xenografts can be made from resected tumors of pancreatic cancer patients in order to generate tumor tissue for the testing of tailored drug regimes. However, the majority of patients with pancreatic cancer (and other types of cancer) are not candidates for tumor resection. Scientists at Johns Hopki...
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Inhibitors of Human Methionine Aminopeptidase 1 As Novel Anticancer Drug Leads

JHU researchers have unraveled an important function of human type 1 aminopeptidase (hMetAP1) in the timely progression of cells through mitosis. In addition, a new structural class of isoform specific inhibitors of hMetAP1 has been discovered that induces a significant delay in mitosis (>3 hrs) and...
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Development of a Biomarker for the Early Detection of Diabetes ("Pre-Diabetes") Based Upon O-GlcNAc

JHU scientists have identified markers in human blood that might readily identify individuals at the early stages of type II diabetes, when life-style changes will be most effective in disease prevention. The markers derive from hexosamine metabolism, and in particular the dynamic O-GlcNAc (modifica...
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Controlled Local Delivery of Glucosamine (GlcN) for Musculoskeletal Repair

The novel feature of this discovery is the application of GlcN to joint and spine (cartilage) tissue engineering/repair. Because of this discovery of the relevant concentrations one can envision new therapies such as: 1.) injection into the joint space of GlcN in drug delivery vehicles after microfr...
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Pkd1 T3041R: Pkd1 Cleavage-deficient Mouse

Scientists at JHU have created a novel mouse model of polycystic kidney disease (PKD), one of the most common human genetic disorders. The mice are deficient in Pdk1 cleavage due to missense mutations with the polycystin-1 gene. The mice develop polycystic disease during neo-natal development but un...
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An Approach to Guide the Individualize Development of New Anticancer Agents

The development of new oncology drugs has not resulted in a meaningful improvement in survival of cancer patients. Major reasons are the lack of criteria, models and guidelines to develop individualized treatment plans most likely to produce a successful clinical outcome in a given patient. JHU scie...
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Use of EP3 Receptor Ligands to Reduce Damage from Stroke and Other Neurological Disorders

Cyclooxygenase (COX)-2 inhibitors are well known for their use as anti-inflammatory agents and have also been shown to reduce the damage associated with neuroinflammatory disorders. They act by inhibiting the production of prostaglandins, many of which mediate the inflammatory response. The effect o...
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Use of Novel Derivatives of Artemisinin to Inhibit Toxoplasma Gondii

Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is a medically important infection that is distributed worldwide. Current treatments for the prevention and treatment of toxoplasmosis are of limited efficacy and have undesirable side-effects. According to recent studies, the natural product...
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Inhibition of Transplantation Rejection By Suppressing HVEM

Decoy lymphotoxin beta receptor (LT? has potent immune inhibitory activities, and thus represents a promising biologic for the treatment of inflammation, autoimmune diseases and graft-versus-host disease (GVHD). As this reagent interrupts multiple molecular interactions, including LT?T?and LIGHT-HVE...
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Histone Mutant Plasmid Collections

Epigenetics, the study of stable alterations in gene expression that arise during development and cell proliferation, is a popular area of modern bioscience. The epigenetic context in which genes are expressed is important for understanding normal phenotypic variation and disease. DNA methylation ha...
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Use of High Dose Cyclophosphamide in Combination with Anti-Idiotypic Vaccines in Anti-cancer Therapy

Recently, immunotherapy based techniques have been developed for the treatment of various cancers. The central premise underlying immunotherapy for cancer is the presence of antigens which are selectively or abundantly expressed or mutated in cancer cells. Despite advances in the development of var...
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Use of High Dose Cyclophosphamide in Combination with Immune Therapeutics in Anti-Cancer Therapy

Cyclophosphamide and especially high-dose cyclophosphamide has been used for the treatment of certain autoimmune diseases such as severe aplastic anemia. Low to intermediate doses of cyclophosphamide have also been used in combination chemotherapy for treating certain cancers and appears to work eit...
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Method of Identifying Patients Suitable for High-Dose Cyclophosphamide Treatment

Aldehyde dehydrogenases (ALDHs) are intracellular enzymes responsible for oxidizing aldehydes. A number of studies seem to suggest that ALDH confers resistance of cells to cyclophosphamide, which is routinely used for the treatment of autoimmune diseases and cancer. High dose cyclophosphamide therap...
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Rapid Predictive Assay for Malignancies Treated with Polo-like Kinase-1 (PLK1) Inhibitors and Cell Cycle Modulators

Scientists at JHU have developed a pharmacodiagnostic assay for patients treated with targeted therapies directed at modulating the cell cycle, including but not limited to Polo-Like Kinase-1 (PLK1) inhibitors. The assay uses a fine needle aspirate (FNA) of a neoplastic lesion that is exposed ex viv...
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Protective Effect of Carbon Monoxide (CO) in Stroke

Carbon monoxide (CO) has been shown to mediate both beneficial and deleterious processes in the central nervous system depending on its concentration. CO is produced endogenously through the breakdown of hemoglobin by heme oxygenase (HO) to produce biliverdin, iron and CO, and these physiological co...
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Novel Breast Cancer Cells That Stably Express a New Orange-red Fluorescent Protein Provides Facile Tracking of Metastatic Progression in Live Animal Model Systems

Modeling human disease states in mice has a profound impact on our understanding of disease progression and treatment development. The need for noninvasive longitudinal monitoring of such model systems has resulted in the development of small animal imaging technologies. Endogenously expressed fluor...
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Small Molecules Targeting 5-meCpG Binding Domain Proteins (MBDs) for Cancer Prevention and Treatment, and for Other Clinical Uses

JHU scientists have discovered new small molecules inhibitors of the transcriptional repression pathway mediated by the 5m-CpG-binding family domain proteins (MBD), MBD2 and MeCP2. Both MBD2 and MeCP2 have been found to play critical roles in both the epigenetic silencing of gene in human cancer cel...
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Inhibition of Vif-Cul5 Interaction Through Use of Zinc Chelator

The Vif ? A3G axis is one of the most promising new drug targets in HIV research. Previous studies have discovered that Vif is an HIV-derived protein that acts to derail antiviral efforts from the host cell. Vif tags Apobec3G (A3G), an antiviral host factor, with ubiquitin for destruction in the 26...
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Methods to Reduce Damage from Stroke and Other Neurological Disorders.

Description (Set) Cerebral ischemia (stoke) is an acute neurological condition that is caused by a blood clot that blocks a blood vessel in the brain, while a cerebral hemorrhage (stroke) is caused by a blood vessel that breaks and bleeds into the brain. The result of a stroke is the initiation of ...
...

Low Voltage, High Mass Range Ion Trap Mass Spectrometer for Mars Atmosphere and Other Harsh Environments

The invention is an ion trap mass spectrometer designed for use on the surface of Mars to detect minute qualities of organic and biological compounds that might indicate the presence of life or former life on that planet. Though compact, the instrument has a high mass range that will enable it to fo...
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Methods to Block or Reduce Damage from Stroke and Other Neurological Disorders

Description (Set) An acute neurological condition caused by blood clots that block blood vessels in the brain is cerebral ischemia (stroke) similarly; blood vessel breakage in the brain is cerebral hemorrhage (stroke). These blood vessel miscues result in the initiation of an ischemic cascade that ...
...

Tamoxifen-resistant MCF-7 Breast Cancer Cell Line

MCF-7 cells serve as a prototypic model system for human breast cancer and their response to secretive endocrine response modifiers (SERM) therapy. MCF-7 cells, upon long term exposure to tamoxifen, acquire tam-resistance and continue to grow in the presence of tamoxifen. Description (Set) Prop...
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Novel Inhibitors of CRAC Channel As Immunosuppressants

T cell activation is essential for immune response. It is primarily responsible for graft rejection upon organ transplantation. Moreover, dysregulation of T cells has been implicated in several autoimmune disorders, including MS and rheumatoid arthritis. Existing immunosuppressive drugs have signifi...
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A Novel Method for Generating and Screening Peptides and Libraries Displayed on Adenovirus Fiber

Abstract (Set) Capsid-displayed adenoviral peptide libraries have been a significant yet unfeasible goal in biotechnology. Three barriers have made this difficult: the large size of the viral genome, the low efficiency of converting plasmid-based genomes into packaged adenovirus, and the fact that ...
...

Antipsychotic Drugs that do not elicit Weight Gain by Screening for Influences on Hypothalamic AMP-Kinase and Histamine H1 Receptors

Atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major side effect of weight gain. Ignorance of the mechanism of these orexigenic actions has delayed efforts to develop alternative therapeutic agents. JHU scientists h...
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A Novel Cystic Fibrosis Therapeutic Agent

Abstract (Set) JHU scientists found that a known drug has a novel function as a stimulator of calcium-activated Cl- channels (CaCCs) and, thus, is a potential therapeutic drug in the treatment of cystic fibrosis. Cystic fibrosis is the number one genetic killer of children and young adults in the U...
...

The Consensus Coding Sequences of Breast and Colorectal Cancers

Human cancer is a disease caused by an accumulation of mutations in genes involved in cell cycle regulation. To date only a small fraction of the genes underlying tumorigenesis have been identified, and the number and type of genes responsible are unknown. With the sequencing of the human genome res...
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Melanoma Metastasis-associated Genes As Novel Diagnostic and Prognostic Markers and Therapeutic Targets for Melanoma

The incidence of melanoma is increasing at the highest rate for any form of cancer in the United States and the current lifetime risk in the US is 1 in 68. Presently there are few effective systemic therapies to treat advanced stages of melanoma and the key to improved survival in all affected indiv...
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Genomewide Analysis of Chromosomal Translocation

Abstract (Set) The cancer genome is quite unstable with many aberrant genetic translocations dispersed across its sequence. Many chromosomal translocations result in chimeric transcripts resulting in elevated expression levels, believed to be responsible for tumorigenesis. Therefore, it is importan...
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Monoclonal Antibodies (mAb) Specifically Against Mouse and Human LIGHT and B7-H4

Scientists at JHU have made antibodies against mouse and human LIGHT and B7-H4 molecules. Description (Set) Proposed Use (Set) These mAb could be used specifically to detect the expression of LIGHT and B7-H4 and to block interactions of these molecules with their counter-receptors....
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Candidate Proteasome Inhibitors that Prevent E6 Mediated p53 Degradation and Selectively Kill HPV+ Cervical Cancer

Abstract (Set) High-risk strains of Human papillomavirus (HPV) cause over 90% of cervical cancers. About 20 million people (men and women) are thought to have an active HPV infection at any given time. Yearly, 14,000 cases are diagnosed and 5,000 women each year die of cervical cancer in the United...
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Selective Fluorescent Labeling of S-Nitrosothiols: S-FLOS

Johns Hopkins University is seeking licensees for a powerful analytical and quantitative technique for S-nitrosylation of proteins. S-nitrosylation is a post-translational protein modification that can alter protein structure and activity. Emerging evidence suggests that dysregulation of S-nitrosyla...
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ER alpha M4, ER alpha U4, p16 M4, p16 U5, Hin1 M1, Hin1 U2, RASSF1a M1, RASSF1a U1, RAR beta M1, RAR beta U1, Twist BM2, Twist BU5, APC M3, APC U3, Cylin D2 M1, Cyclin D2 U4, 14-3-3 M2, 14-3-3 U3, HIC

Abstract (Set) Plasmid DNAs incorporating human gene-specific promoter sequences altered by sodium bisulfite treatment. Description (Set) Proposed Use (Set) Their use includes serving as reagents, standards, or controls for assays of gene methylation (e.g. for determining Methylated or unmethy...
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New Angiogenesis Inhibitors Derived from Fumagillin

Angiogenesis, the formation of new blood vessels, is involved in the pathogenesis of a number of common human diseases, including cancer, diabetic retinopathy, rheumatoid arthritis, and macular degeneration. Inhibitors of angiogenesis can be used for the treatment of all aforementioned disease condi...
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Novel Immunotherapy for Contact Dermatitis

Abstract (Set) Allergic contact dermatitis, the third most common reason for outpatient dermatology visits, is an immunological disease that gives significant influences on patient's quality of life and makes enormous economical impacts. Current therapies for contact dermatitis are largely dependen...
...

Mouse Model of Human Head and Neck Squamous Cell Carcinoma

Abstract (Set) Cancers of the head and neck, the majority of which arise in the squamous cells that line the mucosal surfaces in the head and neck, account for 3% of all malignancies in the United States. Human head and neck squamous cell carcinoma is a clinically aggressive tumor, and fewer than 5...
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PSMA-targeted Nanoparticles for Therapy of Prostate Cancer

Description (Set) Targeted therapy for cancer has gained considerable importance recently with various improvements not only in target identification, but also in small molecule or antibody development. It has also been demonstrated that polymeric nanoparticles can passively target tumors via the e...
...

MicroRNAs As Targets for Anti-Angiogenic Therapies

MicroRNAs (miRNAs) are 18-24 nucleotide RNA molecules that regulate the stability or translational efficiency of target mRNAs. miRNAs are frequently dysregulated in cancer cells and can act as oncogenes and tumor-suppressors. The proto-oncogene c-MYC encodes a transcription factor that regulates ce...
...

Drugs Targeting Cancer Stem Cells

The study of cancer stem cells is important for the development of new cancer treatments. Existing chemotherapeutics may eradicate the bulk of a tumor but residual stem cells may remain to initiate new tumor growth. Novel treatments that target cancer stem cell will help to eliminate the source of ...
...

Topical Administration of Peripherally Acting Drugs for the Treatment of Chronic Pain

Abstract (Set) Clinicians currently have few therapeutic options when it comes to treating chronic neuropathic pain. Drugs available on the market today are not effective in all patients, and often result in partial alleviation of pain. Multiple studies have shown that opioids are effective in trea...
...

N171-82Q Huntington's Disease (HD) Mouse Model

This transgenic line expresses an N-terminally truncated human huntingtin cDNA that encodes 82 glutamines and encompasses the first 171 amino acids. The altered huntingtin cDNA is under the control of a mouse prion protein promoter. Expression is observed in neurons of the central nervous system. ...
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Biocompatible "smart" nanogels as carriers for hydrophobic drugs

The present invention involves a biocompatible nanogel composition for the delivery of hydrophobic substances that are not readily soluble in organic solvents. These nanogels have been designed to contain hydrophobic cores which encapsulate the insoluble molecules, and a hydrophilic shell which allo...
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The Immediate Early Gene Arc Interacts with Endocytic Machinery and Regulates the Trafficking and Function of Presenilin

Abstract (Set) These discoveries promise a novel approach to develop agents to regulate presenilin 1 (PS 1) and treat Alzheimer's Disease and age-dependent memory decline. PS 1 functions as part of the gamma secretase (protease) complex that acts on amyloid precursor protein (APP), Notch and severa...
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Ligands for Nicotinice Acetylcholine Receptors, and Methods of Making and Using Them

One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of the invention for modulation of a mammalian nicotinic acetylcholine receptor. The present invention also ...
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A "Molecular Switch" in Group 1 mGluR Signaling Relevant to Neurological and Psychiatric Diseases

Abstract (Set) Reported here is the mechanism by which group 1 metabotropic glutamate receptors (mGluR) are co-functional with dopamine receptors or growth factor receptors. This convergent signaling is central to understanding several diseases including drug addiction, inflammatory pain, schizophr...
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Multitypic Recombinant Adenovirus Vaccines Against HPV

This invention is a vaccine against human papillomavirus infection consisting of recombinant adenoviruses that are engineered to include peptides of the human papillomavirus 16 minor capsid protein (L2). The L2 sequences are displayed on the outside of the adenovirus particles, where they induce imm...
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Small molecule as Novel Anti-tumor and Anti-angiogenic Agent

Abstract (Set) JHU scientists found that a known antibiotic that inhibits the type 2 methionine aminopeptidase and possesses anti-angiogenic activity both in vitro and in vivo. It causes both primary human endothelial cells and cancer cells to undergo senescence. It was demonstrated that this antib...
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The Direction of Controlled Heat Specifically to Cancer Cells to Enhance Therapeutic Responses to Combination Therapy

The novel featues outlined in ths invention are: 1. The use of localized limited heat that is specifically directed to the cancer cells and their environment to sensitize the cell to combination therapeutic approaches including cytotoxic, immunologic and radiation therapy. 2. To enhance this effect ...
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Liposomase for the Tumor-specific Delivery of Chemotherapeutic Drugs

The challenge in developing effective cancer treatments is in achieving specificity so that only cancer cells are destroyed. JHU scientists have developed a novel drug delivery system that overcomes the problems caused by the low specificity of chemotherapeutic drugs. The technology utilizes a uniq...
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Method of Synthesis of Chemospheres and Chemogel, Hydrogel Embolic Particles and Gel for Locoregional Delivery of Therapeutic Agents and Immunoisolation of Cellular Therapeutics

Description (Set) JHU scientists have developed a method of producing innovative biocompatible compositions useful for variety of therapeutic applications. The biocompatible polymer gel compositions are innovative in the way that they incorporate trackable contrast agents and bioactive agents for s...
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High throughput generation of water-in-oil emulsions for molecular genetic analyses

Researchers have developed a technology called BEAMing (Beads, Emulsion, Amplification and Magnetics), which can assess millions of molecules simultaneously for the study of human genetic variation (see invention number 4273 for more details). Following the development of BEAMing, JHU researchers m...
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Mouse Adult Kidney Stems Cells Modulate Function of Dendritic Cells

Abstract (Set) Recent data has suggested that stem cells, such as mesenchymal cells derived from bone marrow, demonstrate an immunosuppressive ability and could represent a new approach for the treatment of immune-related disorders and the regeneration of damaged tissue. Organ resident cells, on th...
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Novel Class and Clinical Application of Antithrombotic Agents that Specifically Inhibit Inflammation-related Vascular Occlusion

Inflammation is known to be an integral part of the vascular occlusive events that occur during heart attack and stroke, although the specific pathway that links inflammation to clot formation has not previously been determined. Using both in vitro and in vivo studies, JHU researchers have identifi...
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Functional Cardiac Tissue Engineering Using Nanostructured Scaffolds for Cardiac Cell Therapy & High-Throughput Drug Screening

This technology incorporates a method to guide the three-dimensional growth and generation of functional cardiac tissues with controlled and enhanced electrophysiological properties using a nanostructured tissue scaffold. Ultraviolet (UV)-assisted capillary lithography or nano-imprinting technique i...
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Discovery of Novel HTLV-3 and HTLV-4 Retroviruses

Scientists at JHU have recently discovered the existence of two new types of Human T Lymphotropic Viruses (HTL-V), HTLV-3 and HTLV-4, which may be transmitted within humans. The HTLV-4 and HTLV-3 are serologically indistinguishable from existing HTLV-1 and HTL V-2 using current assays and this may ...
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Epigallocatechin-3-Gallate (EGCG) Enhances CD8+ T Cell Mediated Anti-Tumor Immunity Induced by DNA Vaccination

Immunotherapy and chemotherapy are generally effective against small tumors in animal models of cancer, but many tumors can grow rapidly and become resistant to both therapies. JHU researchers have now shown that this resistance can be overcome by combining immunotherapy using DNA vaccination with ...
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Alteration of the Albumin-bound Protein/peptide Complex (ABPPC) is Biomarker for Disease

JHU scientists have invented a cost-effective, rapid, and sensitive assay that characterizes proteins differentially bound to albumin in diseased and healthy patients and is compatible with current blood collection protocols. The current hypothesis states that albumin changes with disease, and there...
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Formation of Functional Motor units and Recovery from Paralysis Using Embryonic Stem Cell Transplantation

The technology describes the potential of embryonic stem cell-derived motor neurons to functionally replace those destroyed in a paralyzed rat model. JHU researchers have successfully demonstrated the ability to increase the success of transplanted axons extending out of the spinal cord into ventral...
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ATR-Seckel Cancer Cells for Drug Discovery

Advanced gene targeting methods were used to generate biallelic knock-in point mutations in human colorectal cancer cells that cause a loss of ATR function, but retain enough activity to permit viability. JHU researchers determined that progression of the cancer cell cycle after radiation treatment ...
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Tumor Repressor Genes in the Prevention of Cancer

Some epidemiological studies suggest that many solid tumor types occur less often than predicted in individuals with Down syndrome. Using mouse models of trisomy 21 and cancer, scientists at JHU have provided biological proof of this phenomenon. In doing so, they propose to have identified a novel ...
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Sequence Motifs that Direct Nuclear Import of Small RNAs

Small RNA species, such as small-interfering RNAs (siRNAs) and microRNAs (miRNAs), have important roles in gene silencing and possess great potential for the development of novel therapeutics. Researchers at Johns Hopkins University have discovered the first known sequence element that regulates the...
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Role of Kv Channels in Neuroregeneration and Protection

Injury to the human central nervous system (CNS) is usually difficult to treat because of the limited regeneration capabilities of the neurons. Evidence suggests that the lack of CNS regeneration is due to the presence of inhibitory factors in the CNS environment. While there is clearly a great need...
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Vaccine to Prevent/Treat Esophageal Cancer in Individuals with Barrett's Esophageal Metaplasia

Esophageal cancer affects approximately 14,000 individuals per year in the United States, is increasing in incidence, and is associated with an exceptionally high mortality rate. The poor outcome in patients with esophageal cancer is reflective of both deficiencies in early detection - the disease i...
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Development of Peptide Antibody Depletion (PAD) and its Application to Mass Spectrometry Sample Preparation

One of the major limitations of mass spectrometry is obtaining mass information on proteins in the presence of contaminating materials or other high abundant proteins that, when present in the sample, suppress the observation of proteins of interest. JHU scientists have developed a novel application...
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Embryonic Stem Cells from Animal Models of Motor Neuron Diseases Including Spinal Muscular Atrophy (SMA) and Amyotrophic Lateral Sclerosis (ALS)

Progress in the development of therapies for motor neuron diseases has been hampered by the lack of effective cell culture models. Since spinal motor neurons selectively die in ALS and SMA, an effective cell culture model must have mature motor neurons that have the genetic defect found in humans wi...
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Processes for Regulating Blood Glucose in a Mammal and Novel Polypeptides Useful in Nad Biosynthesis

Scientists at JHU have discovered of a novel blood-circulating form of Nampt. This novel isoform a slightly higher molecular mass compared to the intracellular form of Nampt and is mainly secreted by brown adipose tissue or cells in mice. Scientists at JHU also have created a novel use for the HIB-...
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Phase 2 Inducers and Related Signaling Pathways Protect Cartilage Against Inflammation/Infection, Apoptosis and Stress

The molecular pathogenesis of arthritis associated with increased chondrocyte apoptosis is earmarked by over-expression of cyclooxygenase-2 (COX-2) in articular tissues. COX-2 inhibitors are efficacious in the treatment of osteoarthritis and rheumatoid arthritis but clinical findings of serious gast...
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TC-1/A2

Scientists at JHU have developed an HLA-A2 expressing tumor mouse model that can naturally process and present E7 antigen via HLA-A2 molecules. Description (Set) Proposed Use (Set) This mouse model should be useful for assays of HLA-A2-restricted E7-specific antitumor responses and antitumor ef...
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A Rapid Assay Using Fine Needle Aspiration (FNA) to Test for 5-fluorouracil Dosing and Efficacy

Scientists at JHU have developed a functional assay for a class of widely used anti-cancer drugs, 5-fluorouracil and related compounds (5FU). The assay is based on Fine Needle Aspiration (FNA) of any neoplastic lesion from a patient being treated with 5FU, and processing of the material for thymidyl...
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The Use of Lumican as an Inflammation Modulator

This technology identifies an extra-cellular matrix protein, lumican, that plays a role in the inflammation pathway. This protein is present in the skin, cornea, intestines and blood vessels, and modulates its action through cell surface signaling molecules. Mice deficient in lumican have are resist...
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Multiple Inversion Flip Flop (MIFF) Vectors

JHU researchers have developed novel Multiple Inversion Flip Flop (MIFF) plasmid vectors for controlling the expression of transgenes that are either stably-integrated or transient. These vectors comprise a cytomegalovirus (CMV) promoter flanked by LoxP sites in opposing orientations, which allow fo...
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SIV Clonal Isolates: SIV/17E-Fr, SIV/17E-C1, SIV/3-11RG, and SIV/3-7

Abstract (Set) JHU researchers have constructed infectious simian immunodeficiency virus (SIV) molecular clones that differ in their Env and Nef proteins. These clones display differences in neurovirulence and cellular tropism. Description (Set) Proposed Use (Set) SIV clones for studying cell...
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Identification of E. Coli Determinants Contributing to Bacteremia that Form the Foundation for Development of Vaccines Against E. Coli Bacteremia Andsepsis

E. coli is the most common gram-negative organism causing nosocomial bacteremia and bacteremia in VA and elderly patients. The mortality and morbidity associated with E. coli bacteremia is substantial. For example, E. coli sepsis is associated with an estimated 40,000 deaths each year at a cost of t...
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Multifunctional Neck Brace

strengthening of cervical muscles and the prevention of atrophy of cervical muscles; and graduated mobility and improved comfort in patients with a disease attributable to the cervical region of the spinal column. All braces distribute the weight of the head more evenly to the base of the brace surf...
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Augmentation of Endocardial Thromboresistance

A critical function of the endocardium is to maintain local thromboresistance by providing an anticoagulant surface. Thrombomodulin, is expressed on the surface of the endocardium endothelial cells and is the key component of the anticoagulant protein C pathway, and thus is critical to maintaining v...
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Cell Lines that Express SIV/HIV Receptors and Co-Receptors in the K562 Human Cell Line

Both simian and human immunodeficiency viruses (SIV and HIV) utilize chemokine receptors, with or without CD4, as portals for entry into susceptible cells. JHU researchers constructed a reporter cell line derived from non-susceptible human K562 cells, xKLuSIV, that can be used to readily identify c...
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HOXB7 as a Potential Prognostic Marker and Therapeutic Target in Cancer

Scientists at The Johns Hopkins University have determined that HOXB7, a member of homeobox superfamily of transcription factors, regulates the expression of EGFR/ER2 and ER?and functionally orchestrates their function in breast cancer cells. In addition, the amelioration of HOXB7 expression using s...
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MEK KO Lines for Drug Discovery

MEK knockout in human colorectal cancer cell line HCT116. Description (Set) Proposed Use (Set) MAP kinase/ERK kinase (MEK) is the specific activator of extracellular signal-regulated kinase (ERK) and is part of a signaling pathway with a pivotal role in the control of cellular proliferation. Th...
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Line 1: Pkhd1flox3-4 mouse line, formal name Pkhd1tm1Ggg.; Pkhd1del3-4 mouse line, formal name Pkhd1tm1Ggg.1

Pkhd1flox3-4, when mutated, causes human autosomal recessive polycystic kidney disease (ARPKD). The Pkhdlde13-4 allele results after Cre-mediated deletion of exons 3 and 4. Homozygosity for this allele results in a wide range of abnormal phenotypes including ductal plate malformations of the liver, ...
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Neuroprotective Actions of Polyphenols, Flavonoid Derivatives and their Respective Extracts

Polyphenols, such as resveratrol, have been linked to many health benefits. This widespread belief stems from its intrinsic antioxidant properties that protect against oxidative damage. Recently, other data has suggested that polyphenols act as signaling molecules to regulate gene expression, the h...
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NAC-1 Monoclonal Antibody

Scientists have developed a human NAC-1 monoclonal antibody. The antibody can be applied by immunohistochemistry, Western blot and immunoprecipitation to detect NAC-1 protein expression. Description (Set) Proposed Use (Set) This antibody has the potential to be used as a diagnostic reagent for...
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Estrogen Receptor in Normal (ERIN) Cells

There is no ideal system for studying pre-neoplastic cells that are ERpositive due to the inability to establish an estrogen growth stimulated but non-tumorigenic breast epithelial cell line. Scientists at JHU have developed independently derived clones from the non-cancerous MCF-10A human breast ce...
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Promoters for Neural Regeneration

Background Injury to the human central nervous system (CNS) is usually difficult to treat because of the limited regeneration capabilities of the neurons. Evidence suggests that the lack of CNS regeneration is due to the presence of inhibitory factors in the CNS environment. Myelin-associated Glycop...
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Compounds with Effects on Potassium Channels

KCNQ channels play a role in cardiac and neuronal membrane excitability. Scientists at JHU have identified a series of novel compound that potently activates KCNQ channels. Initial studies of electrophysiology using whole cell recording and animal models revealed that the compound potentiates KCNQ c...
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Inducing and Inhibiting T Cell Tolerance with A2a Receptor Agonists and Antagonists

T cells play a critical role in fighting disease and infection. However, when T cells recognize and attack normal or non-infected cells, autoimmunity ensues. A contrasting, but similarly detrimental situation is T cell tolerance, the state of antigen-specific unresponsiveness in the absence of immun...
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The MR-eye: Methods and Devices for Local MRI

The present invention is a novel method to lock the MRI frame-of-reference to an internal device, where the RF excitation is confined to the immediate region surrounding the probe. Two dimensions are encoded using cylindrical encoding or conventional read/phase encoding. The third dimension is resol...
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Protein-Encapsulated Aligned Fibers by Electrospinning for Enhanced Peripheral Nerve Regeneration

We have developed novel protein-encapsulated fibrous meshes that are composed of micro-/nano-sized aligned fibers. The encapsulated protein in the fibers can be released in a sustained manner for up to several months while maintaining partial bioactivity. Direct application of these aligned electros...
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MR-visible and radiopaque microcapsules for use as embolic agents and for immunoisolation of cellular therapeutics

Immunoisolation of cells through microencapsulation is a means to prevent their immune destruction following transplantation. To date, microencapsulation has shown great clinical potential for a wide range of diseases requiring enzyme or hormone replacement therapy, particularly diabetes. This inven...
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A. phagocytophilum Monoclonal ab hybridomas

Researchers at JHU have created hybridomas producing monoclonal antibodies reactive with the obligate intracellular bacterium Anaplasma phagocytophilium 44kDa antigens (Msp2), AnkA and unidentified labile antigens. Description (Set) Proposed Use (Set) Useful tool for immunohistochemistry, immun...
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Novel Compounds that Target Estrogen Receptor (ER) Positive. Tamoxifen-resistant Breast Cancers

The drug tamoxifen is widely used to treat estrogen receptor (ER) positive breast cancer and to prevent relapse. However, half of all recurrences in breast cancer patients are resistant to tamoxifen and often, more aggressive tumors result. Recently, researchers at The Johns Hopkins University, in ...
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Trioxane Dimers Having Surprisingly High Anticancer Activities and Surprisingly Long-lasting Antimalarial Activities

Artemisinin (1), a monomeric 1, 2, 4 trioxane, is usually administered for the treatment of multi-drug resistant malaria. However, studies have determined that artemisinin not only possesses excellent anti-malarial properties but also considerable anti-cancer activities. Dimeric trioxanes also posse...
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Co-assembling Peptide Hydrogels

Peptide-based hydrogels have become popular for biomedical applications such as tissue engineering and drug delivery due to their biodegradable and bioresorbable properties. For use in vivo, hydrogels should assemble easily in a controlled fashion and be compatible with native entrapped biomolecules...
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Developing a High-throughput Screening Method for Identification and Validation of T Cell Epitopes Based Upon the Mass Spectral Analysis of Antigens Bound to Class II HLA-DR Constructs

All currently established methods for the identification of immunogenic epitopes are extremely tedious, time consuming and frequently unsuccessful. The identification of high throughput methods to isolate most likely candidates derived from natural processing of protein antigens is a most desirable...
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A Fast, Cell-based, High-throughput Assay for the Identification of Compounds with DNA-interstrand Crosslinking Capability

Using somatic cell gene targeting, isogenic cell clones were created from the colorectal cancer cell line RKO. Each KO cell line differed only in the allelic status of one Fanconi Anemia (FA) gene, either FANCC or FANCG. For details, see publication by Gallmeier, E et al., 2006. Description (Set) ...
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Novel methods for genetic calcium channel blockade

The development of left ventricular hypertrophy (LVH), irrespective of etiology, confers an incremental risk of adverse outcomes in the general population and in patients with different forms of cardiovascular disease. Importantly, LVH is also an early event in patients destined to develop congesti...
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TGFbeta Antagonists, Including AT1 Receptor Blockers, Rescue the Multisystem Pathogenesis of Marfan Syndrome

This invention is based on the discovery that excessive activity of an important signaling protein, TGF?likely underlies a variety of problems in Marfan syndrome, including the tendency to develop emphysema. The many problems associated with increased TGF?ignaling can be rescued by TGF?ntagonism. Th...
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Prostate Specific Membrane (PSMA)-binding Peptides Useful for Targeted Therapy for Cancer

Prostate-Specific Membrane Antigen (PSMA) is a glutamate carboxypeptidase II that is expressed by normal prostate epithelium and is even more highly expressed by a large proportion of prostate cancers and other tumor types. As PSMA is not expressed in the normal endothelium of non-prostate tissues, ...
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Peptide Substrates for Fibroblast Activation Protein (FAP) that can be Used to Generate FAP-activated Prodrugs and Protoxins

Fibroblast activation protein alpha (FAP-alpha) is a membrane bound serine protease that is only produced by reactive stromal cells present within sites of epithelial cancers. FAP-alpha is not expressed within normal stroma of any other adult tissues and therefore represents a potential target for e...
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Antibody Based Anti-HIV-1 Microbicide Targeting a Host Protein

Development of microbicides to prevent HIV-1 transmission to women plays a valuable role in stemming the worldwide epidemic of the disease. In order to address some of the shortcomings of microbicides currently in advanced stages of clinical testing, scientists at JHU explored the development of an...
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Johns Hopkins University PROTEIN-DB2 Database System

Genomic data collection follows the workflow of amplification of DNA expression, amplified DNA extraction, high-throughput sequencing, and subsequent processing/analysis of the sequence data. DNA itself is a structurally stable molecule that can withstand cell lysis and remain relatively intact. Pro...
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Emission Ratiometric Kinase Activity Reports in High Throughput Drug Screening and Analysis

Protein phosphorylation is one of the major regulatory mechanisms controlling cellular functions and aberrant kinase activities are found to form the molecular basis for many disease phenotyes. As a result, protein kinases are well recognized as important drug targets and are a focus of small molecu...
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Chemical Control of Trk Signaling in Mice

Neurotrophins are a family of molecules that encourage survival of nervous tissue by secreting factors in a neuron's target field, and act by prohibiting the neuron from apoptosis. The neurotrophin family include nerve growth factors nerve growth factor (NGF), Brain-derived neurotrophic factor (BDNF...
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Tetrahydrobiopterin for Treatment of Cardiac Failure and Remodeling

Tetrahyrdobiopterin (BH4) is an obligate cofactor for the aromatic amino acid hydroxylases (tyrosine, tryptophan, and phenylalanine), as well as for the nitric oxide synthases. It is currently used clinically in a subset of patients born with an inborn error of metabolism known as phenylketonuria (P...
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Identification of Novel Putative Endogeneous Angiogenic Protein Inhibitors

The present invention identified over 70 novel putative endogenous angiogenesis inhibitors using methods of bioinformatics. Classification of these inhibitors is based on conserved domains of known anti-angiogenic fragments. Utilizing bioinformatics algorithms and searching the human protein databa...
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Web-Based Diabetes Data Management Application

Intensive control of blood glucose levels may delay the onset and progression of microvascular complications that contribute to the morbidity and mortality of patients with type 1 and type 2 diabetes melltus. Treatment regimens targeting intensive control rely on the administration of multiple dose...
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Johns Hopkins Diabetes Management Program

The invention encompasses a team of health care professionals who directly manage the pharacologic, nutritional and educational components of the medical care plan for hospitalized patients with diabetes mellitus. The director of the team wil be a board certified endocrinologist, who wil be responsi...
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New uses for old drugs: Identification of Hedgehog pathway antagonists previously tested in humans

Hedgehog (Hh) pathway activity is responsible for the growth of lethal cancers such as small cell lung cancer, and carcinomas of the esophagus, stomach, pancreas, biliary tract, and prostate, and account for as many as 25% of cancer deaths. Evidence for the critical role of continuous Hh pathway ac...
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A New Method to Increase Memory T Lymphocytes and Enhance their Functions for Resistance of Cancer and Infections

CD137 has long been recognized as a co-stimulatory receptor for growth and functional maturation of recently activated T cells in the presence of T cell receptor signal. Now, researchers at JHU have discovered a new method to grow memory T lymphocytes and to stimulate their function. In addition, th...
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pT2cfosGW

A current hypothesis is that sequences conserved over greater evolutionary distances are more likely to be functional than sequences that are less well conserved. In order to identify non-coding regulatory sequences, scientists at JHU developed a novel reporter vector based on the Tol2 transposon, a...
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Site-specific Modification of the Human Genome Using Custom-designed ZFNs

Scientists at JHU have designed sets of Zinc Finger Nucleases (ZFN) to target mouse genes, namely the tyrosinase (mTYR) and CFTR (mCFTR) and human genes, namely the CCR5 co-receptor (hCCR5) through which HN gains entry into cells early in the infection; the DMPK gene, which is involved in myotonic ...
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Molecular Targets for the Anti-cancer Natural Product Pateamine A

v The natural marine product Pateamine A (PatA) is a potent anti-tumor and pro-apoptotic agent. Until recently, PatA?s mechanism of action was unknown until scientists at JHU determined that the protein inhibits cell proliferation through blockade of eukaryotic translation initiation. Specifically, ...
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S9

Cystic Fibrosis bronchial epithelial cell line isolated from a patient with genotype ?508 /W1282X. IB3-1 Cells were immortalized with adeno12SV0 and later infected with a viral vector AAV carrying CFTR full length. Description (Set) Proposed Use (Set) This cell line may be useful in the discov...
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A Novel Statistical Method to Identify Robust Prostate Cancer Marker Genes

The most commonly used diagnostic screen for prostate cancer (measurement of levels of prostate specific antigen) is now known to function very poorly as a disease biomarker. The test developed in this work exhibits performance that dramatically exceeds that of PSA. The invention is the TSP (Top Sco...
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C38

JHU scientists have created a Cystic Fibrosis bronchial epithelial cell line that was isolated from a patient with genotype ?508/W1282X. Cells were immortalized with adeno12SV0 and later transfected with a cDNA from AAV carrying CFTR truncated for the first 119 amino acids. Description (Set) Pr...
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Interference of the mir-17 miRNA Cluster as a Novel Cancer Therapeutic Strategy

The MYC cancer gene increases the expression of a cluster of microRNAs that are implicated in the development of human cancers. Researchers at JHU have discovered that MYC regulates a growth regulator, E2F1, through several miRNAs. This novel discovery suggests that interference of E2F1 or other tar...
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RAS KO Lines for Drug Discovery

RAS gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Parsons et al., 2005 Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for novel molecules that target the RAS pathway in human canc...
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Neuroprotection Actions of EP1 Receptor Drugs

Prostaglandin E2 is the primary product of arachidonic metabolism and is synthesized via the prostaglandin and cycloxygenase pathways. The hormone-like chemical has been shown to affect the central nervous system and can modulate synaptic transmission and neurotransmitter release, the sleep/wake cy...
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A New Method for High-efficiency Integration of Transgenes into Bacterial Chromosomes without a Drug Marker

This invention allows the insertion of foreign DNA into an innocuous site in the bacterial chromosome using the site-specific recombination system of Tn7. Drug selection is not required since this integration event occurs in up to 97% of cells treated. The plasmid that carries this system is curable...
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Arginase, a Target Enzyme for the Treatment of Myocardial Dysfunction in Aging and Heart Failure

We have identified a novel method to treat heart failure and age related myocardial dysfunction by inhibiting the enzyme Arginase. The seminal observations underlying this claim involve the following: We have demonstrated The expression of arginase I and II in rat heart and isolated cardiac myocyte...
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Revolving Robotic Needle Driver

Abstract (Set) Image-guided robots are manipulators that operate based on medical images. These are modern medical tools with applications in most medical fields, allowing the physicians to perform interventions not only under direct vision, but with the additional help of the transcutaneous data. ...
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Genome-wide Direct Transcription Measurement using Array-based Assay of Labeled Nascent RNA

Description (Set) JHU scientists have developed, optimized and validated an innovative approach for study of nascent RNA transcription. Post-transcriptional regulation of gene expression constitutes critical and wide-spread mechanisms. However, only ongoing transcription accurately reflects momenta...
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Tandem L2 Fusion Vaccines for Prevention of Human Papillomavirus Infection

Abstract (Set) HPV infection causes 5% of human cancers worldwide. Prevention of HPV infection will eliminate HPV associated cancers and their precursors. However, current licensed vaccines are derived from Ll capsid protein and only target a subset of the oncogenic HPV types (and therefore Pap scr...
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L2 Lipopeptide Vaccine for Prevention of Human Papillomavirus Infection

Abstract (Set) Human papillomavirus (HPV) infections are the most common sexually transmitted infection in the United States. Infection by over 15 different oncogenic HPV genotypes is a cause of cervical cancer. Therefore, a low-cost, broadly protective vaccine that can be delivered without needles...
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Cardiac Stem Cell and Myocyte Secreted Paracrine Factors

Abstract (Set) Stem cells hold the promise to revolutionize future reparative medicine through the development of stem cell-based therapies. Transplanting stem cells (either embryonic or adult derived) into damaged myocardium is emerging as a novel means for acute repair and as an alternative to or...
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Imaging Methods for Assessment and Quantification of in vivo Antigen Capture and Vaccination

Abstract (Set) Immunization has eradicated many harmful infectious diseases in the Western world. This is commonly achieved by injecting individuals with attenuated pathogens such as viruses and bacteria. By using cancer vaccines, similar success will be achieved for eradicating the most common for...
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Ras-regulated microRNAs as a novel anti-cancer therapeutic strategy

Abstract (Set) MicroRNAs (miRNAs) are 18-24 nucleotide RNA molecules that regulate the stability or translational efficiency of target mRNAs. miRNAs are frequently dysregulated in cancer cells and can act as both oncogenes and tumor-suppressors. It is estimated that there are approximately 37,170 n...
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CisGenome Software

Abstract (Set) Chromatin immunoprecipitation followed by genome tiling array analysis (ChIP-chip) or by massively parallel sequencing (ChIP-seq) is an extremely powerful tool to understand gene regulatory programs in development and disease. CisGenome is a software system for analyzing genome-wide ...
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Technique for Identifying and Measuring Narp in Plasma

Abstract (Set) JHU scientists have developed a method of concentrating Neuronal activity regulated pentraxin (Narp) in plasma using taipoxin bound affinity beads. The concentrated Narp is detected using western blot methodology. The method can be used as a diagnostic tool for evaluating the physiol...
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Mosquito-based Malaria Transmission-blocking Antibodies

Abstract (Set) A single effective vaccine against malaria is lacking. As such, the global research effort has focused on developing a "cocktail" vaccine, wherein different life stages of the parasite can be targeted specifically by separate vaccine components. Therefore, one vaccine component of in...
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Tumor Suppressor MicroRNAs Controlling Cancer Cell Growth

Description (Set) Johns Hopkins scientists have discovered two microRNAs that are expressed in normal blood cells, but are not expressed in virtually any of the leukemia-lymphoma cell lines and primary patient samples which have been tested to date. The miRNAs are not expressed in other types of so...
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Method for Investigating Long-Range Chromatin Interactions in Vivo

Abstract (Set) The packaging of DNA into chromatin, the complex of DNA and protein that makes up chromosomes, is an important mechanism for regulating gene expression. Recent studies demonstrate that long-range chromatin interactions play an important role in transcriptional regulation of genes. Cu...
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Cost-Effective Method for High-Throughput and Quantitative Analysis of DNA Methylation

Abstract (Set) Investigators at Johns Hopkins University developed a simple and cost-effective approach to detect and quantify the status of DNA methylation, termed MSqFRET. This method couples the well established methylation-specific PCR (MSP) technology with quantum dot-mediated fluorescence res...
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http://www.jhttportal.jhu.edu/TechTransfer/TechnologyLocator.asp

Description (Set) JHU inventors have identified a population of microRNA (miRNA) associated with a critical neurotransmitter transporter gene regulatory region. miRNA has roles in modulating gene expression levels. Transporter activity is essential to maintain proper neurotransmitter levels in the ...
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Novel Antibiotic Treatment of Gliosarcoma Reduces Tumor Size and Increases Survival

Abstract (Set) The present invention is directed to methods of using a bacteriostatic antibiotic to treat glioma and other brain tumors including astrocytoma, oligodendroglioma, glioblastoma multiform but also other cancer types including breast cancer, cervical cancer, AIDS related cancer, gastric...
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LRRK2 Fly Model for Parkinson's Disease

Abstract (Set) Mutations in the leucine rich repeat kinase (LRRK2) gene causes late onset autosomal dominant Parkinson's disease (PD). The LRR protein has two enzyme activities (kinase and GTPase) which play important roles in regulating neuronal death and other cellular functions. We have created ...
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Methods to Reduce Mesh Spacing of the Protective Mucus Barrier

Description (Set) Human mucus forms a protective barrier to toxins and infectious pathogens on all the most susceptible surfaces of the body such as the lung airways, gastrointestinal tract, nose, eye, and female reproductive tract. Mucus possesses a mesh-like structure which evolved viruses can by...
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The Method to Enhance Death of Cancer Cells

Abstract (Set) B7-H1 is an immunoglobulin-like immune suppressive molecule broadly detectable on the majority of human and rodent cancers and its functions have been attributed to delivering an inhibitory signal to its counter-receptor programmed death-1 (PD-1) on T cells. JHU scientists have disco...
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Radiolabeled Analogs of Cyclopamine for Imaging Hedgehog Signaling

Description (Set) The hedgehog (Hh) signaling pathway is increasingly recognized as an important therapeutic target in cancer. When Hh signaling goes awry patients may develop a wide variety of tumors including medulloblastoma, glioblastoma, pancreatic cancer, prostate cancer, among others. In addi...
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Immunoliposomal Delivery of Vaccine to the Spleen

Abstract (Set) A fundamental problem in all vaccination methods is to present the target antigen to the appropriate population of cells so that the immune system will be sufficiently activated to mount an immune response against cells that exhibit the target antigen. The problem in many cases is th...
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Molecular Insights into Breast Cancer Prevention and Therapeutics Involving Novel Genistein Analogs

Abstract (Set) Cancer is the second leading cause of death in the U.S. and claims the lives of around 555,000 Americans each year. An estimated 1.3 million new cases of cancer are reported in the U.S. each year, of which breast cancer accounts for 15.3 percent. In Asia, an area with high soya isofl...
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Rapid Induction of Cancer Cell Death by Synergistic Treatment of Tetra-O-methyl Nordihydroguaiaretic Acid (M4N) with either Two Specific Kinase Inhibitors

Abstract (Set) M4N is an anti-cancer drug candidate, which is currently under the first phase of clinical trials. Although M4N can reduce tumor cell growth; it fails to induce quick tumor cell death. JHU scientists showed that the combination treatment of M4N with either two specific kinase inhibit...
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Dually Targeting the PI3K/Akt and MAP Kinase Pathways in Poorly Differentiated and Undifferentiated Thyroid Cancer Cells has High Therapeutic Promise

Abstract (Set) JHU scientists have discovered an innovative method of targeting aggressive thyroid cancers that are resistant to conventional treatment. Poorly differentiated anaplastic thyroid cancer cells do not respond to radioiodine treatment due to abnormal silencing of iodide-metabolizing gen...
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Detection of Virus Exposure as an Etiological Agent in Patients with Sudden Onset of Psychosis

Description (Set) JHU scientists have developed an assay based on detection of certain viral antigens in patients with a sudden and unexplained onset of psychiatric symptoms. This discovery is rooted in the premise that some viruses are implicated as etiological agents in neurological conditions. J...
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Salivary Rinse and Serum Detection Test for Head and Neck Cancer

Description (Set) A Johns Hopkins University investigator has identified unique profiles of hypermethylated gene promoters that are effective markers of risk for head and neck cancer. Head and neck squamous cell carcinoma (HNSCC) is a disease that is often diagnosed at an advanced stage. The result...
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Beta-3 Adrenergic Receptor Agonists Reduce Cardiac Hypertrophy and Heart Failure

Abstract (Set) This invention is based on the discovery of a novel role for beta-3 adrenergic receptors (B3AR) in the control of cardiac hypertrophy when the heart is under physical stress. The precise role of B3AR in the heart has not been previously elucidated. In general, beta-1 and -2 adrenergi...
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Cancer Immunotherapy Using Irradiated Tumor Cells Secreting Hsp 70

Abstract (Set) Ovarian cancer is responsible for the highest mortality rate among patients with gynecologic malignancies. Therefore, there is an emerging need for innovative therapies for the control of advanced ovarian cancer. Immunotherapy has emerged as a potentially plausible approach for the c...
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Novel Cell Surface Receptor Variants as Biomarkers for Hormone-Refractory Human Prostate Cancer

Abstract (Set) Prostate cancer cells depend on hormones and hormone receptor activity for growth and survival. Some prostate cancer cells progress to a phenotype that is aggressive and no longer susceptible to hormone therapies that are standard treatments for prostate tumors. JHU scientists have i...
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High Affinity Small Molecule Inhibitors of Hepatitis C NS3/4A Protease

Description (Set) Hepatitis C virus (HCV) infection is a growing global health problem with over 3 million new cases of HCV infection each year. Johns Hopkins University scientists have discovered a new class of small molecule non-peptidic inhibitors of the HCV NS3/4A protease. The HCV NS3/4A prote...
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Monoamine oxidase (MAO) inhibitors reduce cardiac hypertrophy and prevent heart failure

Description (Set) JHU scientists have developed a method to reduce heart muscle cell changes that lead to heart enlargement and congestive heart failure, using agents that inhibit monoamine oxidase (MAO) activity. MAO functions in normal metabolism as an oxidizing enzyme and is present in cardiac m...
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Novel Peptide and Delivery Method for the Treatment of Human Cancers

Description (Set) The PIK3 signaling pathway has recently been recognized a major player in the regulation of cell survival and cell proliferation as it relates to cancer. Scientists at JHU have utilized a small peptide based upon a component in this pathway to block cell proliferation and cell cyc...
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A Predictive Test for Determining Chemotherapy Regimens in Patients with Cancer

Abstract (Set) The ability to predict sensitivity to individual cytotoxic chemotherapies could improve treatment response and survival of cancer patients. There is currently no method in routine use to determine sensitivity to agents directed at the microtubule, and particularly the taxanes. JHU sc...
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Carcinoembryonic Antigen as a Potential Biomarker for use in Targeted Drug Delivery Applications as well as Other Therapeutic Strategies

Abstract (Set) Blood-borne metastasis is a highly regulated and dynamic process, whereby cancerous cells separate from a primary tumor, migrate across blood vessel walls into the bloodstream, evade host defenses, adhere to the vascular endothelium of distant organs, extravasate and colonize these s...
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Mutational Analysis of the Serine-threonine Kinome in Colorectal Cancers

The invention describes novel mutations in serine-threonine kinase genes within the Phosphatidylinositol-3-OH Kinase (PI(3)K) pathway in patients with colorectal cancer. Details are described in the paper by Parsons et al., 2005 (see below). Description (Set) Proposed Use (Set) The discovery of...
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Mouse Monoclonal Antibody 8A2

Abstract (Set) This technology is a mouse monoclonal antibody, which specifically recognizes vertebra SUMO-2 and SUMO-3. SUMOylation is essential for cell-cycle regulation in invertebrates; however, its functions during the mammalian cell cycle are largely uncharacterized. Mammals express three SUM...
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Modulation of Regulatory T cell (Treg) Function

Abstract (Set) Regulatory T cells (Treg) are a subset of the CD4 T cell population that down-modulate an immune response. In some diseases, i.e. autoimmunity, Treg activity can prove beneficial by inhibiting a pathological response. However, under other conditions, including but not limited to...
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Instrument System for Managing and Cherry Picking Microorganism Collections

Large biomaterial collections require precise and selective access to a subset of material under sterile conditions. JHU researchers have invented a novel integrated instrument system built from existing standard components that allows efficient management of large, complex libraries of biomaterials...
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Short Chain Fatty Acid (SCFA) - Carbohydrate Bifunctional Hybrid Molecules with Novel Anti-cancer Properties

Butyrate, a natural short chain fatty acid (SCFA), is well-established to have anti-cancer properties via its ability to induce cell cycle arrest and apoptosis in cancer cells. Currently, several clinical trials are underway for treatment of cancer (leukemia, prostate, sickle cell ulcers and liver d...
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Hi-Throughput Assay for Screening Small Molecule Inhibitors of Uracil DNA Glycosylase

Uracil DNA glycosylase (UDG) is one of the primary enzymes that prevents the incorporation and accumulation of deoxyuridine in genomic DNA. The identification of pharmacologic agents that inhibit UDG is desirable for both investigational and therapeutic purposes. JHU scientists have developed a nove...
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Total Human Serum Free IgE Immunoenzymetric Assay (IEMA)

Xolair (generic name, omalizumab) is currently approved by the FDA for the treatment of extrinsic asthma. Presently, there are no serological markers or assays for monitoring the efficacy of prolonged Xolair therapy in patients with extrinsic asthma. Monitoring the free IgE level in the blood is on...
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Large-scale Survival, Differentiation and Structural Integration of Human Neural Stem Cells Grafted into the Adult

The present invention provides methods and compositions for treating spinal cord diseases and injuries. The methods involve transplanting neural stem cells which have been previously expanded in vitro into a patient such that the cells can ameliorate the disease or injury. The stem cells to be trans...
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Inhibition of Ischemia-induced Arrhythmias by Blocking Mitochondrial Inner Membrane Ion Channels

This invention describes a method for preventing and/or terminating ischemia-related arrhythmias by targeting the mechanism responsible for the electrical instability occurring during an ischemic episode or upon reperfusion of the heart. Inhibition of a mitochondrial inner membrane anion channel, ei...
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Novel Drugs for the Treatment of Optic Nerve Disease

A small molecule library was screened using an RGC cell culture system for novel factors that promote RGC survival and outgrowth. Five novel compounds have been identified that promote the development of neuritis and/or survival of cultures of retinal ganglion cells. These compounds are beneficial i...
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Method for identifying mutations in coding and non-coding DNA

Annotation of the completed human genome has demonstrated that about 1.5 % encodes protein. About twice (roughly 3.5%) falls within non-coding sequence and is suggested to be functional based on extensive (>50nt) sequence conservation. The remainder of the genome consists of non-coding DNA with less...
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Gowth of Mesenchymal Stem Cells Under Non Adherent Conditions for Clinical Applications

The use of bone marrow derived mesenchymal stem cells (MSC) has been proposed for a number of regenerative therapies including repair of myocardial tissue. The data to date has suggested improved functional outcomes but have failed to demonstrate incorporation of MSC into the tissue. These studies ...
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Immortalization of Nociceptive Dorsal Root Ganglion Sensory Neurons

This invention involves a novel method to immortalize nociceptive dorsal root ganglion (DRG) neurons. DRG neurons are terminally differentiated cells that extend long axons to their target tissues. More than half of all DRG neurons are unmyelinated axons that extend to the skin and have nociceptive ...
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Neuropilin-1 Sema Mice

Neuropilin-1 (Npn-1) is a receptor that binds ligands from structurally distinct families like semaphorins (Sema) and vascular endothelial growth factors (VEGF). Npn-1 is a type I transmembrane protein with a small cytoplasmic domain and multiple extracellular domains capable of mediating a variety ...
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Reactive Oxygen Generating Enzyme Inhibitor with Nitric Oxide Bioactivity and Uses Thereof

In the US, CHF is the number one cause of hospitalization in people over age 65, and it affected approximately 5 million people in 2004. This translates into a potential cost of $29 billion for the healthcare system. In the US over half a million new cases are diagnosed with, and over 50,000 individ...
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A Compression Device for Enhancing Normal/Abnormal Tissue Contrast in MRI

This invention is a pneumatic device for detecting breast cancer with MRI. The device enables imaging of the elasticity (stiffness) of the tumor and mechanical properties of the surrounding tissue through the use of the SENC (Strain Encoding Imaging) spectrum. The SENC technique also allows for real...
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Inhibiting Binding of Inducible Nitric Oxide Synthase to Cyclooxygenase-2 to Treat Inflammation

Cyclooxygenase (C0X2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Inducible NOS specifically binds to C0X2 and S-nitrosylates it, enhancing C0X2 catalytic activity. Selectively disrupting iN0S-C0X2 binding prevents NO-mediated activation of C0X2. The synergistic ...
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Targeting of Stat-3 Signaling in the Hematopoietic System Evokes Multicomponent Therapeutic Antitumor Immunity

The immune system can act as an extrinsic suppressor of tumors. Therefore, tumor progression depends in part on mechanisms that down modulate intrinsic immune surveillance. Identifying these inhibitory pathways may provide promising targets to enhance antitumor immunity. Scientists at Johns Hopkins...
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HAUSP KO Lines for Drug Discovery

HAUSP (also known as USP7) deubiquitinase gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Cummins et al., 2004a (see below) Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for nove...
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XIAP KO Lines for Drug Discovery

X-linked inhibitor of apoptosis protein (XIAP) gene knockouts of human colon cancer cell lines. Details are described in the paper by Cummins et al., 2004 (see below). Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for novel molecules tha...
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DEC1 KO Lines for Drug Discovery

Deleted in esophageal cancer 1 (DEC1) gene knockouts of the human keratinocyte cell line, HaCaT. Details are described in the paper by Zawel et al., 2002 Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for novel molecules that target the TG...
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CHK2 KO Lines for Drug Discovery

Chk2 protein kinase gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Jallepalli et al., 2003 (see below). Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for novel molecules that tar...
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RAF KO Lines for Drug Discovery

BRAF kinase gene knockouts of human cancer cell lines. Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for novel molecules that target the RAF pathway in human cancer cells or to confirm the specificity of drugs discovered through other ap...
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Dicer KO Lines for Drug Discovery

Dicer RNase gene knockouts in human cell lines. Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for novel molecules that target the miRNA pathway in human cancer cells or to confirm the specificity of siRNA-based drugs discovered through ...
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PIK3CA KO Lines for Drug Discovery

PIK3CA knockouts in human colorectal cancer cell lines HCT116 and DLD1. Details are described in the paper by Samuels et al., 2005 Description (Set) Proposed Use (Set) JHU scientists have recently discovered that mutations in PIK3CA occur in a significant fraction of cancers. Knockout lines ind...
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SMAC KO Lines for Drug Discovery

Second mitochondrial-derived activator of caspase (SMAC; also known as Diablo) gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Kohli et al., 2004 Description (Set) Proposed Use (Set) The cell lines described in this invention can be used...
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p16 KO Lines for Drug Discovery

p16 tumor suppressor gene knockouts of the human colorectal carcinoma cell line, HCT116. Details are described in the paper by Bachman et al., 2003 Description (Set) Proposed Use (Set) The cell lines described in this invention can be used in screens for novel molecules that target the DNA meth...
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PTEN KO Lines for Drug Discovery

PTEN is a tumor suppressor gene that is frequently mutated or deleted in a variety of human cancers . PTEN functions primarily as a lipid phosphatase and plays a key role in the regulation of the PI3 kinase/Akt pathway, thereby modulating cell proliferation and cell survival. JHU researchers have c...
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MTAP KO Lines for Drug Discovery

Methylthioadenosine phosphorylase (MTAP) plays an important role in the salvage pathway for the synthesis of adenosine. The loss of MTAP function has been implicated in a variety of cancers. JHU researchers have created MTAP knock out cell lines. Description (Set) Proposed Use (Set) The cell l...
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Selectively Targeted Histone Deacetylase Inhibitors

Inhibitors of histone deacetylases (HDAC) are regarded as an important approach to cancer chemotherapy, since they disrupt the aberrant cellular metabolism that occurs in many tumor types. The HDAC inhibitors currently in clinical trials and typified by compounds such as trichostatin (TSA) and MS-27...
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Use of Consensus Sequence as Vaccine Antigen to Enhance Recognition of Virulent Viral Variants

Vaccines for diverse viruses will be most effective when they direct the recipient?s response to recognize the most virulent form of the organism. Scientists at JHU have found that circulating strains of hepatitis C virus (HCV) contain substitutions that render the virus less fit. Therefore, the use...
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Generation of Isogenic Lines Differing Only in MLH1 Status

JHU researchers have created matched cell lines which are isogenic, differing only in the MLH1 alleles. One line has two defective alleles, the other has one defective allele and one normal (wild-type) allele, which was generated by targeted homologous recombination ("knock-in"). One wild-type allel...
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A Novel Genetic Approach to inhibit or Eliminate the Tumorgenicity of Human Embryonic Stem Cells and/or their Derivatives After Transplantation

Pluripotent embryonic stem cells have enormous potential for providing an unlimited supply of multipotent and specialized cells, such as brain and heart cells, for transplantation and cell-based therapies that are otherwise limited by donor availability. However, this promising application is hamper...
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B(subscript 1)-Insensitive T(subscript 2) Magnetization Preparation for Magnetic Resonance Imaging at High Field

T2 magnetization preparation is a commonly used MRI technique that enhances the contrast between arteries and surrounding tissues. Recently, high field imaging has shown promising results in acquiring high signal-to-noise images with sufficient spatial resolution suited for clinical diagnosis. Howev...
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Identification of PSCA as an Immune Relevant Target of Antitumor Immune Responses

Prostate Stem Cell Antigen (PSCA) was previously identified as a biomarker for pancreatic and prostate cancer. JHU researchers have shown that a pancreatic cancer vaccine induced immune responses against PSCA in patients who demonstrated a positive clinical response, identifying PSCA as a candidate ...
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New Analogs of the Hormone 1(alpha)25-Dihydroxyvitamin D with Side Chain Carbonyl Groups

Medicinal chemists are designing analogs to be at least as potent as, but less calcemic than, the natural hormone la, 25-dihydroxyvitamin D3 (calcitriol) for chemotherapy of diverse human illnesses. Scientists at JHU have previously shown that some new vitamin D analogs, even though lacking the clas...
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Strategies for Designing Drugs that Target the Sir2 Family of Enzymes to Treat Multiple Diseases

Sir2 enzymes comprise a unique class of NAD+ -dependant protein deacetylases that are involved in a broad range of biological processes including transcriptional silencing, aging, fat mobilization and regulation of the p53 tumor suppressor gene. The Sir2 proteins catalyze NAD+ -dependant acetylatio...
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High Fidelity DNA Display for the Evolution of Combinatorial Libraries

This invention relates to a method of producing combinatorial libraries from non-biological molecules coupled with replication of selected compounds. Individual molecules used to construct the library are attached to specific DNA sequences that are assembled as polymers, and so each combinatiorial c...
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Platelet Endothelial Cell Adhesion Molecule-1 Gene Polymorphism and its Soluble Level are Associated with Severe Coronary Artery Stenosis in Chinese and Asian Indians

Many established risk factors in atherosclerosis and Coronary Artery Disease (CAD) have been defined for Caucasians but not for other ethnic groups. For example, the Asian Indians have 4 times higher prevalence of CAD compared to Caucasians. Thus, there is an urgent need to find novel risk factors/g...
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High Fidelity DNA Display for the Evolution of Combinatorial Libraries

This invention relates to a method of producing combinatorial libraries from non-biological molecules coupled with replication of selected compounds. Individual molecules used to construct the library are attached to specific DNA sequences that are assembled as polymers, and so each combinatiorial ...
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Function of GDE Protein Family in Cellular Differentiation

This technology describes a novel retinoid-inducible gene, GDE2 (glycerophosphodiester phosphodiesterase 2) that encodes a 6 TM protein and is necessary to drive spinal motor neuron differentiation in vivo. A single amino acid mutation in the extracellular catalytic domain removes protein function a...
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PDE Inhibitors in Immunotherapy

Defects in the immune system of tumor-bearing hosts can dramatically preclude effective immune-therapy. JHU researchers and others have previously described some of the cellular and molecular mechanisms responsible for these defects and have shown that the inhibition of these pathways can facilitat...
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A method for high-efficiency clonal isolation and expansion of human embryonic stem cells

JHU researchers have developed a method and identified growth factors for high efficiency cloning, clonal expansion and subculture of human embryonic stem (hES) cells. The invention further describes a method for rapid, high-throughput screening (including genetic screening) for agents (genes, growt...
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Facile Modification of Collagen Directed by Synthetic Peptides

mechanical properties. Such modification may allow attachment of bioactive agent that can bring in designed bioactivity to natural collagen. Most of the techniques practiced today for collagen modification involves simple "blending method" which results in weak attachment of the target molecules or ...
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Method for the direct extraction of isothiocyanates into the seed oil from glucosinolate-containing plant seeds

JHU researchers have developed a methodology for simple, reliable, stable, and inexpensive incorporation of plant isothiocyanates into oils such as natural plant seed oils. Some plant isothiocyanates are cancer chemoprotective, antibiotic, or insect repellents. These oils are ideal for topical derm...
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Diagnostic Tool for Diagnosing Benign Versus Malignant Thyroid Lesions

Thyroid cancer represents 1% of all malignant diseases and it is estimated that 5-10% of the population will develop a clinically significant thyroid nodule during their lifetime. The best available test for thyroid nodule is fine needle aspiration biopsy (FNA). The diagnosis of malignant thyroid tu...
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Methods and Compositions for Treatement of Intraepithelial Neoplasia

The present invention provides for compositions, kits and methods for treatment of intraepithelial neoplasia, where the compositions include catecholic butanes, which include NDGA derivatives Patent (Set) PCT/US05/25639...
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BACE2 Knockout Mice

Two beta-secretases termed BACE1 and BACE2 have been shown to generate the Alzheimer's disease Abeta peptides. To examine the physiological roles of BACE2 and to determine whether BACE2 is the major beta-secretase in neurons, Johns Hopkins University researchers have created mice with targeted inac...
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Multi-turn Element RF Coil Array for Multiple Channel MRI

An RF coil assembly for use in a multiple receive-channel MRI system is provided. The RF coil assembly is configured as a multi-turn-element RF coil assembly 200 to operate as a surface-coil array in cooperation with the MRI system 100 which is configured to operate in a multiple-channel receive mod...
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Pleiotrophin is a Neurotrophic Factor for Spinal Motor Neurons and Dorsal Root Ganglion

This invention utilizes pleiotrophin (PTN), a growth factor of the cytokine family, as a neurotrophic factor for both the motor and the sensory neurons of the PNS. In animal and tissue culture models, PTN has been shown to protect motor and sensory neurons from death and promote regeneration of thei...
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Implantable Microstimulators for Gastrointestinal Tract

This technology constitutes implanting neuromuscular micro-stimulators with an endoscope into the gastrointestinal tract. The micro-stimulators are targeted to areas of dysfunction, and stimulate or inhibit the gastrointestinal tract. The micro-stimulators can be controlled by the patient using a ?...
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Pyruvate Dehydrogenase Kinases as Therapeutic Targets for Cancer and Ischemic Diseases

This invention addresses two desired outcomes relating to cells exposed to ischemic or low oxygen tension by modulating the activity of a mitochondrial matrix enzyme. Tumor cells that have low oxygen tension survival mechanism may be thwarted and killed and critical cells for survival may be treated...
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Development of Novel Approaches to Combinatorial Antifungal Drug Therapy

This invention relates to a method of treating fungal infections. Fungal infections can be life-threatening to transplant patients, cancer chemotherapy patients, AIDS patients and others in immunocompromised conditions. Pathogenic fungi represent an increasing clinical challenge because existing ant...
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A Dwarf Mouse with Growth Hormone Deficiency Due to Targeted Ablation (Knock Out) of the GHRH Gene

The proliferation of pituitary somatotroph cells and the synthesis and secretion of GH are under the stimulatory control of the hypothalamic peptide GHRH. GHRH is initially synthesized as pre-prohormone and then enzymatically cleaved to its mature form (44 amino acids in humans and 42 in mice). Alth...
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Use of Amniotic Fluid (AF) in Ocular Disease

Human amniotic membrane (HAM) has been used successfully in recent years to treat various ocular ailments such as ocular chemical burns, corneal ulcers, and persistent corneal epithelial defects. The efficacy of HAM stems from its mechanical properties as a bandage and the presence of various intrin...
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Use of Amniotic Fluid (AF) in Ocular Disease

Human amniotic membrane (HAM) has been used successfully in recent years to treat various ocular ailments such as ocular chemical burns, corneal ulcers, and persistent corneal epithelial defects. The efficacy of HAM stems from its mechanical properties as a bandage and the presence of various intrin...
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Emission Ratiometric Indicators of Intracellular Cyclic AMP and Epac Activation

The classic second messenger, cAMP, coordinates many cellular functions via its effectors such as Epac (exchange proteins directly activated by cAMP) and PKA (cAMP-dependent protein kinase). JHU inventors have developed a series of emission ratiometric reporters as research tools for measuring the p...
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Transgenic Mice that Express Human Superoxide Dismutase 1 with the Following Mutations (1) a Double Mutation at Residue 46 and 48 with Histidine 46 Mutated to Arginine and Histidine 48 Mutated to Glut

Mutations in superoxide dismutase 1 cause familial forms of amyotrophic lateral sclerosis (ALS). To investigate potential mechanisms of disease pathogenesis, transgenic mice that express human superoxide dismutase 1 with the following mutations were generated: (1) a double mutation at residue 46 and...
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Imaging Tissue Deformation Using Strain Encoded (SENC) Magnetic Resonance Imaging (MRI

Strain Encoded (SENC) MRI is a novel technique for the direct imaging of regional deformation (contraction and stretching) or elasticity of tissues. Deformation of tissue results in changes in intensity of the resulting strain-encoded (SENC) images that is observed as contrast in the images. Also, d...
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Fluorescence Assay for Type IB DNA Topoisomerases for Use in High-Throughput Screening of Small Molecule Libraries

This invention describes the first continuous spectroscopic assay for DNA topoisomerase IB that allows monitoring of the reaction under multiple turnover conditions. As these enzymes are established targets for anticancer and antiviral drug therapies, this assay allows the rapid screening of chemic...
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LOI of lgf2 Increases Intestinal Stem Cell Compartment and Adenoma Formation

This invention provides a strategy for identifying patients at risk of colorectal cancer, and likely other tumor types, by the discovery and identification of an expanded stem cell population in such patients, as well as methods for its detection. Description (Set) Proposed Use (Set) Rapid tes...
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New Inhibitor of HIV-1 Replication, Ubiquitin Like Protein ISG15

The AIDS epidemics are still not limited, especially in the developing countries. The antiviral therapy used in this country is not affordable in the undeveloped countries. In the United States, current technology is ineffective against the generation of drug resistant HIV-1 variants. As such, an al...
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OS-9 Interacts with Hypoxia-inducible Factor 1(alpha) and Prolyl Hydroxylases to Negatively Regulate HIF-1 Activity

Hypoxia-inducible factor 1 (HIF-1) functions as a master regulator of oxygen homeostasis in metazoan species and mediates changes in gene transcription in response to changes in cellular oxygenation. The half-life of the HIF-1a subunit is determined by oxygen dependent prolyl hydroxylation, which is...
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Cloning and Isolation of the Large Ribosomal Subunit Proteins from E. coli for the in vitro Reconstitution of functional 50S Subunits

For the first time, JHU researchers have cloned, expressed and purified each of 34 individual large ribosomal subunit proteins for E. coli for use in vitro ribosome reconstitution reactions. The ready manipulation of ribosomes assembled from their component substituents will permit fine-tuning of th...
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Modification of Professional Antigen-Presenting Cells with Small Interfering RNA (siRNA) Targeting BAK and/or BAX Can Enhance DNA Vaccine Potency

dendritic cell survival by co-administering DNA encoding antigen with DNA encoding inhibitors of apoptosis to DCs. We previously tested a variety of anti-apoptotic factors for their ability to enhance DC survival and antigen -specific CD8+ T cell immune responses when co-administered with DNA encodi...
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The Use of Cerebralspinal Fluid as Inter-subject Normalization Reference Standard for Magnetization Transfer Weighted Imaging

This invention describes the use of cerebrospinal fluid (CSF) as an inter-subject reference standard for magnetization transfer (MT) imaging. This is useful in cases where the standard MT referencing approach (MT ratio or MTR) does not work properly, for instance as demonstrated for the spinal cord ...
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HMG-1 transgenic mouse

The HMG-I/Y gene is overexpressed in human cancer, although a direct role for this gene in transformation had not been established. JHU researchers have generated transgenic mice with HMG-I targeted to lymphoid cells. All 7 informative founder HMG-I mice developed aggressive lymphoma by a mean age o...
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Control of Proliferation and Apoptosis in Cancer Cells

pp32 (ANP32A) is a protein expressed in stem-like normal cellular compartments and in human cancers, such as breast and prostate, that exerts multiple complex functions. Collectively appear to control whether a cell retains proliferative capacity, terminally differentiates, or undergoes apoptosis. T...
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Identification of a Specific Ligand for Siglec-8

JHU scientists have created a unique, carbohydrate-based chemical structure that binds to the cell surface protein Siglec-8, which is expressed by human eosinophils, basophils and mast cells. Siglec-8 reduces the activity of these cells and when bound by modulators, Siglec-8 signals eosinophils to r...
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Hypomorphic Mouse Mutant of PASG, an SNF2L factor, that leads to growth retardation and premature aging that is associated with replicative senescence, genetic instability, decreased stem cell expansi

Researchers at JHU have shown that PASG (Proliferation Associated SNF2-Like gene, also termed lsh or SMARCA6) is essential for properly maintaining DNA methylation and gene expression patterns which are required for normal growth and longevity. PASG, a facilitator of DNA methylation, causes global D...
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Genetic Modification of Cells Prior to Delivery to the Heart so as to Improve Electrical and Contractile Function

Heart failure (HF) is a major public health problem in the United States. Despite great strides in the management of HF, it is still associated with high mortality and morbidity. Cardiac transplantation is the only definitive treatment for end stage heart failure, but is limited by the availability ...
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TH, Bcl Conditional KO mouse

Transgenic mouse that lacks expression of Bcl-x in Tyrosine Hydroxylase-positive Neurons. Description (Set) Proposed Use (Set) This mouse is a useful tool for the molecular study of neural disorders, which include neuronal degeneration, protection and response activation. This animal (Bcl-x Mo...
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TH - Cre Mouse

A transgenic mouse, which produces the Cre Recombinase in Catecholaminergic Neurons. Description (Set) Proposed Use (Set) This mouse is a useful tool to study, at the molecular level, neuronal cell degeneration, protection and other related causes for neural cell disorders. This mouse is uniqu...
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Potent, Simplified Derivatives of Immunosuppressive Agents

Pateamine A (PatA), a metabolite from the marine sponge Mycale, is a potent inhibitor of the intracellular signal transduction pathway that emanates from the T-cell receptor and leads to the transcription of cytokines such as interleukin-2 (IL-2). Researchers at Johns Hopkins and Texas A&M have ide...
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PXA1, PXA2, PXA3, PXA4, PXA5, PXA6

The invention consists of low-passage cell lines generated from primary pancreatic cancers established as nude-mice xenografts, and subsequently passaged in vitro. Description (Set) Proposed Use (Set) Due to their low-passage, these cell lines are more representative of the alterations in the p...
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pFex: an Adenoviral Fiber Exchange Shuttle System

The value of re-targeted adenoviral vectors is becoming apparent in the current age of gene therapy. However, the large size and complex organization of adenoviral vectors makes construction of re-targeted viral genomes difficult. The described invention, pFex, provides a very flexible system for th...
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Shh Light2 Cells

Cell line derived from the NIH/3T3 cell line transfected with GLI-responsive Firefly luciferase reporter from H. Sasaki and a constituitive Renilla-luciferase expression vector. Description (Set) Proposed Use (Set) Useful as a cell-based research tool for the quantitative assay of biologicall...
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293 EcR Shh

Cell line for ecdysone-inducible expression of Shh. Description (Set) Proposed Use (Set) This cell line can be used to discover compounds that block activation of the Hh response pathway and abnormal cell growth associated with both types of oncogenic mutation...
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Mutations of the PIK3CA Gene in Human Cancers

Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate signaling pathways important for neoplasia, including cell proliferation, adhesion, survival and motility. To determine if PI3Ks are genetically altered in tumorigenesis, JHU researchers sequenced PI3K genes in human cancers and ...
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4D Digital Rat Whole Body (ROBY) Phantom

The 4D digital rat whole body (ROBY) phantom is a realistic and flexible model of the rat anatomy and cardiac and respiratory motions for use in molecular imaging research. The organ shapes are modeled with non-uniform rational b-spline (NURBS) surfaces, which are widely used in 3D computer graphic...
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Single Cell Analysis of HIV Replication Capacity and Drug Resistance

This invention provides an assay to simultaneously analyze residual susceptibility and reduced replication capacity of drug-resistant viruses which may provide the ability to make more rational therapeutic deciaions in the setting of treatment failure. HIV-1-infected individuals who develop drug-res...
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Alkenal/one Oxidoreductase (AOR) cDNA and Protein

Alkylating agents are useful compounds as anticancer drugs as they possess electrophilic characteristics that can promote cell death by covalently binding to cellular nucleophiles such as DNA and proteins. However, metabolic activation is required to unmask the electrophilicity inherent in their fun...
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Novel Boronic Chalcone Derivatives and Uses Thereof

A class of anti-cancer agents such as chalcones has shown promising therapeutic efficacy for the management of human cancers. Recent studies have shown that anticancer agents such as chalcones induce apoptosis in variety of cell types, including breast cancers. Biochemical experiments showed that t...
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4xwtCBF1-Luciferase and 4xmtCBF1-Luciferase Reporters

4xwtCBF1-Luc(pJH23A) is a luciferase reporter plasmid that contains 4 copies of a binding site for CBF1. It is a tool that provides readout for Notch signaling and for functional analysis of the Epstein-Barr virus EBNA2 protein. 4xmtCBF1-Luc(pJH25A) is the control plasmid containing mutated binding ...
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Forward Trafficking Motifs and their Uses

This technology demonstrates the existence of such dominant forward trafficking signal (FTS) motifs that can override an ER retention signal. Novel amino acid sequence motifs are been identified that elevate cell surface protein expression as much as 100-fold. The invention provides amino acid seque...
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Vascular Barrier Protective Properties of Bioactive Components of Oxidized Phospholipids Released During Acute Injury Conditions

regain vascular integrity and to prevent edema formation. However, mediators that control restoration of endothelial barrier function are largely unknown. JHU researchers have discovered that oxidized products of cell membrane phospholipids that accumulate at sites of inflammation and tissue damage ...
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R-3327-AT6.3

Highly metastatic prostate cancer cell line which will grow both in vitro and in vivo Description (Set) Proposed Use (Set) Technology may be used as a research reagent for prostate cancer research...
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Adeno-Associated Viral Gene Therapeutic for Cystic Fibrosis, TR5/2-CBA-(capital alpha)264CFTR

Cystic fibrosis (CF) is caused by a defect in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR protein regulates the conductance of sodium and chloride across cell membranes and a defect can have a large impact on the salt concentration of organ fluids. The salt conducta...
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JSC1

This primary effusion lymphoma (PEL) cell line was established from lymphomatous peritoneal effusion tumor cells that were anaplastic, large, and hematopoietic in appearance. The resultant cell line has a similar morphology, and phenotype with strong CD45 and CD71, partial CD20, and lambda light cha...
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WNT Pathway Antagonists

The Wnt signaling pathway is known for its important role in inductive interactions that regulate cellular growth and differentiation, and likely also plays important roles in the homeostatic maintenance of post-embryonic tissue integrity. The present invention relates to the discovery that signal t...
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Hedgehog Pathway Antagonists

The Hedgehog pathway is known for its important role in inductive interactions that regulate growth and differentiation, and is likely also to play important roles in the homeostatic maintenance of post-embryonic tissue integrity. The present invention makes available reagents and methods for inhib...
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Hedgehog Pathway Antagonism for the Prevention and Treatment of Metastatic Prostate Cancer

Prostate cancer is the most commonly diagnosed malignancy in men in the United States. Although most prostate cancers are localized and grow too slowly to cause harm, an important minority develop the ability to grow rapidly and metastasize. Researchers have demonstrated that Hedgehog (Hh) pathway a...
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Use of NADPH-dependent alkenal/one oxidoreductase in the Bioactivation of Irofulven and Related Compounds that Preferentially Kill Cancer Cells

Irofulven (6-hydroxymethylacylfulvene, HMAF) is a novel anticancer chemotherapeutic that is under extensive clinical evaluation. It is an alkylating agent that is capable of forming DNA, RNA, and protein adducts that appear to be preferentially cytotoxic to human cancer cells. JHU researchers have ...
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Antibody to Human DNA Methyltransferase 1

We successfully prepared a polyclonal rabbit antibody to a peptide derived from the N-terminus of human DNMT1 (the sub-contractor was provided with the peptide sequence, synthesized the peptide, injected rabbits, and collected the immune sera; we characterized the antibodies and showed the usefulne...
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Phosphodiesterase 5 Inhibition for Treatment of Cardiac Hypertrophy

Phosphodiesterase (PDE) enzymes are a family of proteins that degrade cyclic nucleotides; thus, playing a major role in cell signaling. PDE5a selectively catabolizes cyclic guanosine monophosphate (cGMP). This action is the central mechanism underlying the use of PDE5a inhibitors for the treatment o...
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The BayesMendel Software Library for Predicting Inherited Genetic Susceptability to Cancer

A library of software tools to calculate the risk that an individual carries an inherited deleterious mutation of a known cancer gene. The calculation uses input from the individual?s family history of cancer specified in the form of a pedigree. The algorithm is based on a close adaptation of work ...
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A Cell Line with Targeted Deletions of both Bax and p21

A Bax and p21 knock out cell line in human colorectal cancer cells. Details are described in the papers by Zhang et al. (2000) and Yu et al. (2003). Description (Set) Proposed Use (Set) Cells that lack both a functional BAX and p21 gene are relatively resistant to apoptosis. This cell line can ...
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Cell Lines with Targeted Deletions of SMAD4

Creation of cell lines in which the SMAD4 genes have been disrupted by targeted homologous interation. Description (Set) Proposed Use (Set) Isogenic cell lines with or without intact SMAD4 genes are valuable reagents for studying the cellular effects of TGF-b family members and for discovering...
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hCNT3/PK15NTD

Cell line derived from swine kidney tubular epithelial cells which contains transfected human CNT3 as its only nucleoside transporter. Description (Set) Proposed Use (Set) Can be used to study the role of hCNT3 in modulation the physiological effects of nucleosides such as adenosine and the p...
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Polymerized Myoglobins as a blood Substitute

JHU researchers, in collaboration with other researchers, are developing artificial oxygen carriers to be used in therapeutics. Current artificial oxygen carrying technologies include the use of cell free hemogloblins from either mammalian sources or obtained form recombinant techniques. Hemoglobin ...
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Catheter and Method for Ablation of Atrial Tissue

The current invention is a novel catheter design that allows a wide ring of abalative lesion to be placed on the left atrial endocardial surface surrounding the pulmonary vein. The novel catheter differs from existing devices in that it maintains contact with the endocardial surface over a constant ...
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Human Cancer Cell Lines Deficient in the CDC4 Gene

To assess the role of CDC4 in genetic instability, we generated cells that lack functional CDC4 genes. An abnormal chromosome number (aneuploidy) is a hallmark of human cancer, recognized for nearly a century. However, the mechanism(s) responsible for aneuploidy has remained elusive. Here we report ...
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Human Cancer Cell Line Deficient in the BLM Gene

To assess the role of BLM in genetic instability, we generated cells that lack functional BLM genes. Genetic instability appears to be required for a normal colorectal epithelial cell to evolve into a cancerous one. Bloom syndrome patients have a strong predisposition to cancer that affects a variet...
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A p105-based NF-(kappa) B Super repressor

Nuclear factor (NF)-kB is a family of transcription factors that regulate immune and inflammatory responses, programmed cell death (apoptosis), and developmental processes. In normal cells, NF-kB is latent, and is activated transiently by stimuli and stresses. However, under pathological conditions ...
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Pigment Epithelium-derived Factor as a Therapeutic Agent for Vascular Leakage, and a Peptide or Small Molecule Surrogate as Therapeutic Agent for Vascular Leakage and Neovascularization

Increased vascular leakage is a common feature of a number of disease states, including but not limited to, diabetic retinopathy, diabetic nephropathy, nephrotic syndrome, ascites, and rheumatoid arthritis. Pigment Epithelium-derived Factor is a known protein found in the eye and in the bloodstream,...
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Modulation of Insulin Secretion by Targeting a Novel Pancreatic Hyperpolarization-activated Current Via Pharmacological Intervention and/or Somatic Gene Transfer

An estimated 16 million people in the US alone suffer from diabetes, a disorder of glucose metabolism involving the hormone insulin. Indeed, diabetes is a leading cause of death. Conventional treatments of type-2 diabetes include drugs that improve insulin action and those that enhance insulin secre...
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A Library of a Large Collection of Genotypically Defined Mutants

JHU researchers have generated a library of 1,183 genotypically defined Mycobacterium tuberculosis mutants using transposon-mediated random insertion mutagenesis. The transposon used to generate the library, Himar1, has a small but defined target site allowing the disruption of nearly all open read...
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Transforming Single DNA Molecules into Fluorescent Magnetic Particles for Detection and Enumeration of Genetic Variation

Researchers have developed a technology called BEAMing (Beads, Emulsion, Amplification and Magnetics), which can assess millions of molecules simultaneously for the study of human genetic variation. BEAMing technology converts single DNA molecules into single magnetic beads, each bead possessing tho...
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Stat3 Antagonists and their Uses as Vaccines Against Cancer

The present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing Stat3 (signal transducer and activator of transcription3) expression and/or function in tumor cells and th...
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Bungarotoxin Binding Site (BBS)-tagging of Proteins

A novel approach to tag proteins using a minimal bungarotoxin binding site (BBS-tag). In this method we have developed a new method for the visualization of protein trafficking. We used a 13 amino acid a-bungarotoxin binding site (BTX) derived from the nicotinic acetylcholine receptor to tag the ext...
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Functionalized alpha 7 Nicotinic Receptor Ligands for Imaging

JHU researchers have synthesized a variety of new radiopharmaceuticals for imaging the a7 subtype of nicotinic cholingergic receptors. They are using nuclear medicine techniques, including positron emission tomography (PET) and single photon emission computed tomography (SPECT) to image these recept...
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Method of Gene Transfer to the Cardiac Atria

Successful myocardial gene transfer remains an elusive target. Methods used to date include direct injection, pericardial effusion and intravascular administration. Transmural gene transfer has been achieved, but generally with methods that are not readily transferable to the clinic. JHU researcher...
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Method for Finding Mutations Caused by the Insertion of Repeated DNAs

Retrotransposons are very abundant mobile components of the human genome. They can move from one site to another in the genome. Retrotransposons move from place to place via an RNA intermediate and reverse transcription. They are thus distinct from DNA transposons which move directly at the level of...
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hENT3/PS120

Cell line derived from swine kidney tubular epithelial cells which contains transfected human ENT3. Human ENT3 is a golgi nucleoside transporter. Description (Set) Proposed Use (Set) This cell line can be used to study the role of hENT3 in modulating cellular resistance to cytotoxic nucleosid...
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hENT2/PK15NTD

Cell line derived from swine kidney tubular epithelial cells which contains transfected human ENT2 as its only nucleoside transporter. Description (Set) Proposed Use (Set) Can be used to study the role of hENT2 in modulating the physiological effects of nucleosides such as adenosine and the ph...
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hENT1/PK15NTD

Cell line derived from swine kidney tubular epithelial cells which contains transfected human ENT1 as its only nucleoside transporter. Description (Set) Proposed Use (Set) Can be used to study the role of hENT1 in modulating the physiological effects of nucleosides such as adenosine and the ph...
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Minimally Invasive Surgical Assistance System for Throat Surgery

Minimally Invasive Surgery (MIS) is a surgical approach aiming at reducing the healing time and trauma to the patient as a result of performing surgery on internal organs. In this approach, the treated internal organs are accessed through a small number of incisions in the patient?s body through bod...
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PK15NTD Cells

Cell line derived from swine kidney tubular epithelial cells which are deficient in endogenous nucleoside transporters. Description (Set) Proposed Use (Set) Pharmacological tool for evaluation of cytotoxicity of neucleoside analog drugs in mammalian systems...
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Method for Treating Nausea and Vomiting of Pregnancy

We have developed a new method to treat nausea and vomiting by stimulation vagus nerve fibers in the neck using electrodes attached to a current source. We can also stimulate the vagus nerve fibers using a magnetic stimulator. Description (Set) Proposed Use (Set) This invention is intended to a...
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Spinal Vertebral Interventions by Natural Orifice Translumenal Endoscopic Surgery (NOTES)

Abstract Vertebral spine procedures are currently performed via thoracoscopy and other percutaneous approaches. With the advent of natural orifice translumenal endoscopic surgery (NOTES) techniques, direct access to the peritoneum and mediastinum is possible. This innovative approach to the anteri...
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Hybridoma RG-1

tract JHU scientists generated a monoclonal antibody, RG-1, that binds to highly conserved L2 residues and neutralizes human papillomavirus 16 (HPV16) and HPV18. Passive immunotherapy with RG-1 was protective in mice. Antiserum to the HPV16 L2 peptide comprising conserved residues neutralized pseu...
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Yeast Knockout Mutation (YKO) Collections and Yeast Double Knockout Collections

JHU researchers have produced collections of single and double yeast knockout (YKO) mutants. Description (Set) Proposed Use (Set) Collections of YKO mutants are useful for determining the functions of genes through an analysis of the mutant phenotypes. Double YKO mutant collections or pools ar...
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Inhibitors of Beta Lactamase

The invention provides novel non-.beta.-lactam inhibitors of .beta.-lactamases. In particular, the invention provides boronic acid-based compounds set forth in the specification. These compounds may be used with .beta.-lactam antibiotics to bacterial infection, particularly, .beta.-lactam-antibiotic...
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Suppression of HIV Replication and Prevention/Treatment of HIV-Associated Dementia by Minocycline

This invention describes the addition of a tetracycline derviative to existing combinations of antiretroviral drugs for treatment of HIV-infected individuals. JHU researchers have determined that the tetracycline derivative, which is a potent anti-inflammatory and neuroprotective drug, also inhibits...
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Antitumor Effects Generated by pNGVL4a-Sig/E7 (detox)/HSP70 DNA Vaccine Administered Through Gene Gun, Biojector and Syringe

DNA vaccines have emerged as an attractive approach for antigen-specific cancer immunotherapy. We have previously linked Mycobacterium tuberculosis heat shock protein 70 (HSP70) to human papillomavirus type 16 (HPV-16) E7 in the context of a DNA vaccine. Vaccination with DNA encoding E7/HSP70 has ge...
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Isogenic Cell Lines with or without Intact BAX Genes

To assess the role of BAX in drug-induced apoptosis in human colorectal cancer cells, we generated cells that lack functional BAX genes. Such cells were partially resistant to the apoptotic effects of the chemotherapeutic agent 5-fluorouracil, but apoptosis was not abolished. In contrast, the absen...
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A Defective Response to Hedgehog Signaling in Disorders of Cholesterol Biosynthesis

This invention provides a method to stimulate stem or progenitor cells with a signaling molecule in vitro and produce a uniform population of the desired differentiated cell type. For example, with this approach it is possible to stimulate neural stem or progenitor cells with a signaling protein suc...
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Synthetic mammalian retrotransposon gene

Retrotransposons are infectious pieces of DNA that can insert themselves (a process referred to as retrotransposition) into the genomes of their hosts, which include all mammals, such as human beings. Key to the retrotransposition process is the retrotransposon's ORF2 protein, encoded by the ORF2 ge...
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Anthracycline doxorubicin-resistant carbonyl reductase-1 knock out mice

The cancer treatment drug doxorubicin (brand name adriamycin) is very effective against tumors, but causes a serious side effect of heart damage. This toxicity occurs in part because the enzyme carbonyl reductase metabolizes the drug into a cardiotoxic form. We created mice with one non-functional c...
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Use of Hedgehog Pathway Inhibitors in Small Cell Lung Cancer

We have shown that small cell lung cancer (SCLC), a highly aggressive and frequently lethal tumor, uses an embryonic signaling pathway to promote its growth. This signaling pathway is known as the Hedgehog pathway, and its normal function is to regulate organ formation and regulate progenitor cells ...
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Method for producing diverse libraries of encoded polymers

With our reagents, libraries of drug-like molecules are rendered in a format where they can be subjected to evolution. This enables processing of libraries that are about 10 orders of magnitude more diverse than those typically used in high-throughput screens. Such diversity makes it probable that ...
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Cell Lines Expressing APC in Inducible Manner

JHU scientists have created an inducible expression system for APC in HT-29 colorectal carcinoma cells. Using this novel inducible expression system, it was shown that APC inhibits cell growth through increased apoptosis. Details are described in the paper by Morin et al., 1996 Description (Set) ...
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p21 Knock Out Human Mammary Epithelial Cell Lines

MCF-I0A human breast epithelial cell lines devoid of the p21 gene. Description (Set) Proposed Use (Set) These cell lines could be used to screen for drugs that target the p21 pathway and/or the TGF-beta pathway...
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Transcriptome of Human Hematopoietic Stem Cells

The human CD34+/CD38-/Lin- cell subset comprises ~1-10% of the CD34+ cell population and includes few of the less primitive hematopoietic (lineage-committed) progenitor cells (HPCs), yet contains most of the primitive in vivo engrafting (lympho-) hematopoietic stem cells (HSCs). We analyzed gene exp...
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Eight Anti-ganglioside Monoclonal Antibodies

Monoclonal antibodies to major brain cell surface antigens involved in axon-myelin stability, nerve regeneration, and control of nerve cell signaling. Description (Set) Proposed Use (Set) Diagnostic analysis, neuropathic localization...
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Comparison of HPV DNA Vaccines Employing Intracellular Targeting Strategies

Human papillomavirus (HPV) E6 and E7 are consistently expressed and are responsible for the malignant transformation of HPV-associated lesions. Thus, E6 and E7 represent ideal targets for therapeutic HPV vaccine development. Scientists at JHU previously used a gene gun approach to test several intr...
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Rat 1a-myc

Rat 1a-myc is a human MYC oncogene transformed Rat 1a fibroblast cell line. Description (Set) Proposed Use (Set) This cell line is an ideal tool to study Myc function and transforming activity....
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Digital Karyotyping

Alterations in the genetic content of a cell underlie many human diseases, including cancers. A method called Digital Karyotyping provides quantitative analysis of DNA copy number at high resolution. This approach involves the isolation and enumeration of short sequence tags from specific genomic lo...
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Inhibition of Hedgehog Signaling by Direct Binding of Cyclopamine to Smoothened (Efficient Drug Screening for Thousands of Protein Targets)

Opportunity I: Dysregulation of the Sonic hedgehog-Patched-Gli pathway leads to several human diseases. Disruptions in this pathway during embryogenesis are associated with birth defects. In adults, aberrant hedgehog (Hh) pathway activation is associated with several cancers, including medulloblasto...
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Use of Antibiotic Minocycline in Viral Diseases of the Central nervous System

Diseases associated with West Nile Virus (WNV) and other encephalitis viruses are increasingly common. Plus, currently no treatment exists for any of the encephalitis viruses. WNV alone has become a national problem in just three years since its incidence in the United States, and some studies sugg...
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Novel Tyrosine Kinases Implicated in Colorectal Cancers

Tyrosine kinases (TK) are the regulators of signaling pathways that control cellular functions such as differentiation, transcription, cell cycle progression, and apoptosis. Tyrosine kinases are sometimes mutated in human cancers although it is not known how many, or how often members of the TK fami...
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PUMA Mediates the Apoptotic Response to p53

The p53 pathway is inactivated in the great majority of human cancers. Of the many physiologic effects of p53 that have been described, current evidence suggests that apoptosis is critical for its tumor suppressor activities. Although several genes that might mediate p53-induced apoptosis have been ...
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Isogenic Cell Lines Deficient in DNA Methyltransferase Genes

Cell lines with disruptions of various DNA methyltransferase genes have been created. Description (Set) Proposed Use (Set) Useful for screens to identify drugs that can inhibit the growth of cancer cells with abrnormal methylation....
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Disulfide Constrained Peptides for Targeting the Prostate Specific Membrane Antigen

Utilizing a standard phage display methodology, we have screened a hepta-peptide disulfide bridge constrained phage display library for binding to the prostate specific membrane antigen (PSMA). PSMA is a prostate specific cell surface marker which is up regulated in aggressive prostate cancer and is...
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Design and Synthesis of Renal Dipeptidase Inhibitors

Colon cancer is a deadly disease with a 6% average lifetime risk in the United States. When detected in the earliest stages, patients have a 90% survival rate. In the early stages of colon cancer, however, patients are generally asymptomatic. Therefore, colon cancer is often diagnosed in the late st...
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A Molecular Mechanism for Action of Immunophilins and a Method to Identify Novel Pharmaceuticals

The immunophilins are a family of proteins that are functionally related by their rotamase activity (ie they are peptidylprolyl isomerases, PPIase) and their ability to bind immunosuppressive drugs such as FK-506, rapamycin, and cyclosporin A. Immunophilin ligands also hold great promise for the tre...
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Polyamine Analogues with Significant Antitumor and Antiparasitic Activity

Johns Hopkins researchers have synthesized a novel series of terminally alkylated polyamines that have significant biological activity. Some of the analogues have impressive antitumor activity against cultured tumor cells (ling, breast, prostate, and melanoma), while others have excellent activity a...
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Boronic-Chalcone Analogs as MDM2 Inhibitor

A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human breast cancer cell lines. The results show the boronic-chalcones are more toxic to breast cancer cells compared to normal breast cells than other known chalcones. Description (Set) Proposed...
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Boronic-Chalcone Analogs as MDM2 Inhibitor

A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human breast cancer cell lines. The results show the boronic-chalcones are more toxic to breast cancer cells compared to normal breast cells than other known chalcones. Description (Set) Propose...
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Enhancement of Adenoviral Oncolytic Activity by Modification of the E1A Gene Product

The present invention relates to compositions and methods for enhancing the oncolytic activity of replication-competent, target cell-specific adenovirus vectors by modification of the E1A gene product. The target cell-specific replication-competent adenovirus vectors comprise a chimera of an adenovi...
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Generation of HLA-Ig based Artificial Antigen Presenting Cells

Adoptive immunotherapy involves stimulation of viral- or tumor-specific T cells, ex vivo, followed by transfer of expanded numbers of activated autologous T cells back into patients. While adoptive immunotherapy holds promise as a treatment for both infectious diseases in immunocompromised patients ...
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Expanding Human Embryonic Stem Cells Using human Adult (Marrow) Cells or Derived Molecules

All the existing human embryonic stem cells (hESCs) are derived and propagated on mouse embryonic fibroblasts (MEFs). We established a method to derive and expand human cells (from adults) that can fully substitute MEFs in support of the growth of undifferentiated hESCs. The first type of human cell...
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Hypoxia-induced Mitogenic Factor

JHU researchers have discovered a novel cytokine named Hypoxia- Induced Mitogenic Factor (HIMF; also known as FIZZ1/RELM? a secreted protein that is highly up regulated in the lungs as a result of hypoxia-induced pulmonary hypertension. HIMF profoundly constricts the pulmonary vasculature and partic...
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Cell Lines for Evaluation of 'Beta'-Catenin Function

Mutation in the beta-catenin/APC pathway are responsible for over 90% of all colon cancers in humans. Mutations in the beta-catenin gene activate the activity of this oncogene and cause uncontrolled growth of the affected cells that harbor this mutation. Using our gene targeting technology, we have ...
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Modulators of hedgehog Signaling

Members of the Hegdehog (Hh) family of secreted signaling proteins play critical roles in coordinating cell growth and differentiation. Impaired pathway function in embryogenesis can produce severe malformations, such as cyclopia and other midline defects of the face and forebrain associated with de...
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Tracker Robot for CT-Guided Interventions

A new robotic system for CT-guided operations has been developed to perform precise manipulation of a needle or other surgical instrument in the confined space of the imager without interfering with the imager functionality. This device is connected to the mobile table of the CT, allowing the patien...
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Specific Ablation of STAT3(beta) Distorts the Pattern of STAT3-Responsive Gene Expression and Impairs Recovery from Endotoxic Shock

Stat3 is one of seven mammalian signal transducer and activator of transcription molecules that are activated by the Janus Kinases in response to cytokines. Although originally identified as an acute-phase response factor activated by interleukin (IL)-6, Stat3 is now known to be activated in respons...
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Mutations in Macrophage Scavenger Receptor 1 Gene Increase Risk of Prostate Cancer, Asthma, and Cardiovascular Disease

The present invention discloses methods of screening a subject for increased likelihood or risk of certain diseases or disorders. This method comprises detecting the presence or absence of at least one mutation in the MSR1 gene wherein the presence or absence of such mutation indicates an increased ...
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pNB1 + pNB3

These molecular biology research tools are recombinant yeast plasmids that were designed for use with an in vitro Tn7 transposition system Description (Set) Proposed Use (Set) Genome analysis, characterization and manipulation....
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Simulation System for Training and Pre-treatment Planning of Image Guided Needle Placement Proceedures for Vertebroplasty and Other Orthopedic and Soft Tissue Diagnostic & Therapeutic Medical Applicat

The invention is designed to provide physicians and paramedical medical personnel with a simulation system that will allow them to train, practice and or pre-plan image guided needle placement procedures that have both diagnostic and therapeutic medical applications. The user can interactively manip...
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Non-invasive Diagnostic Imaging Technology for Mitochondria Dysfunction in Man By Using Lipophilic Cations Labeled with F-18 and I-123

In the last decade a new field of ?Mitochondrial Medicine? has been created from the discovery that a wide array of diseases in humans are associated with mitochondrial dysfunction. A partial list of diseases includes Cancer, Autoimmune Disorders, Alcoholic Liver Disease, Cardiomayopathies, Ecphalom...
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Claudins As markers for Early Detection, Diagnosis, Prognosis and as Targets of Therapy for breast Cancer

We have recently identified Claudins 1, 3, 4, and 7 as differentially expressed in breast cancer relative to normal breast tissue. Further studies have shown Claudins 1 and 7 to be down-regulated in primary breast cancers relative to normal breast epithelium. We have generated a rabbit anti-peptide ...
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1. a Family of Novel Flavoenzymes, 151, that Binds Actin and Regulates Repulsive Axon Guidance Through Oxidation-Reduction Mechanisms and 2. a Role for Oxdidation of Actin in Limiting Axonal Outgrowth

We have identified a class of proteins containing members which directly binds to the cytoplasmic domains of plexin receptors in both invertebrates and vertebrates, and we have shown that these proteins are essential for plexin signaling events in the developing nervous system. We have also identifi...
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Enhancing DNA Potency By Co-administration of DNA Encoding Anti-apoptotic Proteins

Intradermal vaccination via gene gun efficiently delivers DNA vaccines into dendritic cells (DCs) of the skin, resulting in activation and priming of antigen-specific T cells in vivo. However, DCs have a limited lifespan, hindering their ability to prime antigen-specific T cells. We reason that a st...
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In Vitro and in Vivo Induction of Potent Bystander Anti-Tumor Effects Through Inhibition of Stat3 Signaling

The present invention relates to methods for modulating, i.e., agonizing or antagonizing, Stat3 (Signal Transducer and Activator of Transcription3) signaling activity for use in gene therapy. Inhibition and/or activation of Stat3 signaling is an effective approach to modulate angiogenesis and the im...
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Cell Line 2V6.11

Abstract (Set) The human adenovirus E4 ORF 6 34 kDa oncoprotein (E4 34k), in concert with the 55 kDa product of E1b, prevents concatenation of viral genomes in infected cells, inhibits the repair of double strand breaks (DSBs) in the viral genome, and inhibits V(D)J recombination in a plasmid trans...
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Software Tools for Analysis of Chromosomal Abnormalities in Pedigrees Using High Density Genomic Data SNPtrio

Abstract (Set) Description (Set) Chromosomal DNA alterations can be detected using high density single nucleotide polymorphism (SNP) microarrays. These include deletions and duplications (assessed by observing changes in copy number) and regions of homozygosity. The analysis of SNP data from tri...
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Three Software Tools for Analysis of Chromosomal Abnormalities in High Density Genomic Data

Abstract (Set) High density single nucleotide polymorphism (SNP) data have been used to identify chromosomal changes in DNA samples. A current challenge is to identify disease associated changes such as deletions and duplications as well as inheritance patterns. JHU scientists have developed a soft...
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Software Tools for Analysis of Chromosomal Abnormalities in Pedigrees Using High Density Genomic Data.

Description (Set) The SNP software analysis tools use a novel "reverse pedigree" method to detect genetic differences between siblings. This reversed pedigree method reveals how regions of chromosomes have been inherited between siblings. Paternal versus maternal inheritance for each region will al...
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Anopheles Gambiae Densonucleosis Virus Expression System

Abstract (Set) Densonucleosis viruses (DNVs) are single-stranded non-enveloped viruses in the family parvoviridae. This invention is the novel Anopheles gambiae densonucleosis virus (AgDNV), and the use of AgDNV as a heterologous system for gene expression, gene silencing and genetic manipulation o...
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A New in Vitro Assay for Evaluating Anti-viral Drug Activity

Abstract (Set) JHU scientists have developed an efficient in vitro single-round virus infectivity assay with a high correlation to clinical outcomes of drug treatment. This reporter virus assay is an accurate, fast way to screen and evaluate anti-viral drugs including anti-HIV therapeutics. Anti-vi...
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Prevention and Treatment of Bacterial and Fungal Meningitis

Description (Set) Johns Hopkins University is currently seeking licensees for a method of preventing meningitis caused by bacterial or fungal infection. Meningitis is a serious and often deadly inflammation of the central nervous system. The most susceptible populations for fungal meningitis are th...
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The New Culture Method of Rat Distal Pulmonary Vein Smooth Muscle Cell

Description (Set) Isolation of primary cell populations is complex and requires a significant amount of technical expertise to produce purified and viable cultures. JHU scientists have developed an optimized method to produce a highly purified population of mammalian intrapulmonary vein smooth musc...
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miRNA Microarray Analysis in Barrett's Esophagus and Esophageal Adenocarcinoma

Description (Set) JHU scientists have discovered independent microRNA specific for Barrett?s esophagus (BE) and Esophageal adenocarcinoma (EAC). These EAC and BE microRNA could be used as diagnostic and prognostic biomarkers. EAC is a lethal condition with a very low 5-year survival rate. EAC and i...
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Methods of Generating Primate Pluripotent Stem Cells from Non-Embryonic Sources

Abstract (Set) Currently, the efficiency of generating human induced pluripotent stem (iPS) cells is low. JHU scientists have found a way to improve it by supplementing an additional gene or bioactive molecules to generate iPS cells from human adult as well as fetal fibroblast. This is the first ti...
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Prostate Cancer Cells Derived from Familial Prostate Cancer Tumor and Methods of Use

A cell line has been generated from a culture of prostate epithelial cells taken from a prostate cancer patient with a strong family history of prostate cancer. This is the first cell line to be generated and characterized from such a patient. Description (Set) Proposed Use (Set) This in vitro...
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Screening Method to Predict Donor Organ Function after Transplantation

Abstract (Set) Transplantation represents an established procedure in end-stage organ failure patients and results in satisfying long-term results. However, this surgical therapy is continuously limited by severe and progressive organ shortages. Therefore, many transplant programs have to extend th...
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Improved Method of Human Embryonic Stem Cell Embryoid Body Formation

Description (Set) JHU scientists have developed an optimized method for culturing and differentiating human embryonic stem (hES) cells. Obtaining sufficient numbers of viable differentiated cells from human embryonic stem cells is a recognized challenge in stem cell culture. It is a critical limiti...
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Diagnostic Biomarkers of Kidney Transplant Dysfunction

Abstract (Set) Johns Hopkins University is currently seeking licensees for a panel of biomarkers for kidney transplant dysfunction. Kidneys are the most frequently transplanted organ in the U.S. Kidney transplant recipients can experience a variety of problems including delayed graft function and a...
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J HIN, J RASSF1A, J TWIST, J HIC Plasmids

Abstract (Set) Plasmid DNAs incorporating human gene-specific promoter sequences altered by sodium bisulfate treatment. The plasmids contain sequences hybridizing to external QM-MSP regions within gene promoters of RASSF1A, TWIST1, NIN1, and HIC1. These areas bracket cloned DNA from non-human sourc...
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Johns Hopkins Approved Wireless Portable Polysomnography Monitoring Device

Abstract (Set) Currently there are no clinically proven portable devices that objectively measure and record sleep activity in a reliable fashion at minimal inconvenience to the patient. While portable sleep testing may currently be used to diagnose obstructive sleep apnea (OSA), the inability to c...
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Selective Prodrug Activation in Cancer Cells Using Protein Switches

Cancer is a major health problem in the world and is the second leading cause of death in the U.S. An estimated 1.3 million new cases of cancer are reported in the U.S. each year. Current chemotherapeutic agents and gene-directed enzyme prodrug therapy (GDEPT; also known as "suicide gene therapy"), ...
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Plasmid pProEX-hOtu1

Abstract (Set) The plasmid pProEX-hotu1 was constructed using vector pProEX and cDNA of human otubain 1. The plasmid was created for expression and purification of recombinant human otubain 1 in E.coli. Description (Set) Proposed Use (Set) The plasmid was created for expression and purificatio...
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Known Drug found to have applicability in the area of glaucoma, optic nerve diseases, and other neurodegenerations

Abstract (Set) According to the World Health Organization, glaucoma is the second leading cause of blindness in the world. One approach to treat glaucoma, and optic nerve diseases as well as other neurodegenerations, is to develop ?neuroprotective? agents that promote the survival of neurons. JHU s...
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Floating Chamber Set for Multi-Well Tissue Culture Plate

Abstract (Set) Description (Set) Clear, precise immunohistochemistry data is reliant on the quality of immunolabeling and the structural integrity of the tissue being examined. Most tissue processing techniques require multiple reagent changes and physical manipulation of small, delicate samples...
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Glutaminase Inhibition to Treat Cancer, Cardiac Ischemia and Stoke

Abstract (Set) A common occurrence in cancer is altered glucose metabolism where cells take up glucose avidly and convert it primarily to lactate, despite available oxygen. These cells also depend on continued mitochondrial function for metabolism, specifically glutaminolysis that catabolizes gluta...
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Collagen Mimetic Peptides for Imaging and Therapy

Abstract (Set) Collagens, the most abundant protein in mammals, provide a structural framework during tissue development and repair. Functionalized collagen that incorporates exogenous compounds may offer new and improved biomaterials applications, especially in drug delivery, multifunctional impla...
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DLD-Chk1 S317A Cells

Abstract (Set) Chk1 kinase acts downstream of ATM/ATR kinase and plays an important role in DNA damage checkpoint control, embryonic development and tumor suppression. JHU scientists have engineered a somatic cell knock in that is deficient for the DNA damage induced activation of the Chk1 kinase. ...
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A Malaria Vaccine to Stop Malaria Transmission

Abstract (Set) Malaria is a disease caused by parasites of the genus Plasmodium. It affects near 2 billion people worldwide and results in 1-2 million deaths every year. Transmission-blocking vaccines (TBV) have received attention as potentially effective strategy in the fight against malaria. Surf...
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COA360.org - Cultural Competency Organizational Assessment

Abstract (Set) Today, four states in U.S. are minority-majorities (California, Texas, New Mexico, and Hawaii) and by 2010 there could be as many as eight. Nearly 18% of Americans speak a language other than English at home. These demographic characteristics have major implications for the healthcar...
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JH-EsoAd1- Esophageal Cancer Cell Line

Abstract (Set) Esophageal adenocarcinoma currently has one of the most rapidly increasing tumor incidences in the United States, with the vast majority of cases occurring on the backdrop of metaplastic epithelium (Barrett esophagus). The availability of appropriate cell line models is essential for...
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Rabbit Serum 2804: Antibodies Against Human LAP2

Abstract (Set) Nuclear lamina is a dense fibrillar network insi