Hiv-rev-multimerization Inhibiting Nanobodies
The present invention relates to an anti-HIV-Rev antibody. More specifically, the invention relates to a nanobody that is able to inhibit the multimerization of the Revprotein, and by this, it inhibits the nuclear export of single-spliced and unspliced HIV-1 m RNA, and can be used as an anti-HIV agent. The invention relates further to the use of the antibody in the screening of compounds that can inhibit HIV-Rev multimerization.
STEYAERT JAN [BE]; PARDON ELS [BE]; DAELEMANS DIRK [BE]; VERCRUYSSE THOMAS [BE]
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