Novel Cross-Linkers for Obtaining Structure Information on Molecule Complexes
The present invention describes a novel cross-linker, a method for preparing one or more cross-linked biomolecules, biomolecular complexes of two or more biomolecules, a method for preparing cross-linked fragments from such cross-linked biomolecules and/or biomolecular complexes, a method for cleavage and reduction of such cross-linked biomolecules and/or biomolecular complexes, a method for identifying cross-links in such cross-linked biomolecules and/or biomolecular complexes, as well as a method for determining relative amounts of cross-links in a biomolecule or biomolecular complex in two or more samples.
DE JONG LUITZEN [NL]; KASPER PIOTR THOMASZ [NL]; BACK JAAP WILLEM [NL]; VAN MAARSEVEEN JAN HERMAN [NL]; DE KOSTER CHRIS GERDINUS
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