Targeting TGF-beta as a Therapy for Alzheimer's Disease
The invention includes compositions and methods for enhancing peripheral macrophage A[beta] phagocytosis activity. The invention includes inhibiting a component of TGF-[beta] signaling pathway in peripheral macrophages to promote central nervous system infiltration and beneficial cerebral A[beta] clearance. Inhibition of TGF-[beta] signaling in peripheral macrophages represents an advantageous anti-amyloid therapeutic approach for Alzheimer's disease.
FLAVELL RICHARD A [US]; TOWN TERRENCE C [US]
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