Targeted Oligonucleotide Compositions for Modifying Gene Expression

The invention comprises compositions and methods for modifying gene expression. Modified oligos of the invention restore the lost function of let- 7 wild type miRNA molecules that are prevented from silencing target genes by mutations occurring within their binding sites. Administration of a particular modified oligo (SEQ ID NO: 22) leads to increased cell death in cancer cells carrying the LCS6 SNP.

Attached files:


Patents:
EP 2,296,669

Inventor(s): SLACK FRANK J [US]; WEIDHAAS JOANNE B [US]

Type of Offer: Sale



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