Anti-viral nucleoside analogs and methods for treating viral infections, especially hiv infections

The present invention relates to novel compounds according to the general Formulae (I, II, III, IV or V); wherein B is nucleoside base according to the structure Formula (VI); R is H, F, Cl, Br, I, C 1 -C 4 alkyl (preferably CH 3 ), -C N, -C C-R a , Formula (VII); X is H, C 1 -C 4 alkyl (preferably CH 3 ), F,Cl,Br or 1; Z is 0 or CH 2 with the proviso that Z is CH 2 and not O when the compound is according to general formula II, R 3 is -C C-H and R 2 is H or a phosphate, diphosphate, triphosphate or phosphotriester group; R 1 is H, an acyl group, a C 1 -C 20 alkyl or an ether group; R2 is H, an acyl group, a CI-C20 alkyl or ether group, a phosphate, diphosphate, triphosphate, phosphodiester group or a Formula; (VIII) or Formula (IX) group; Nu is a radical of a biologically active antiviral compound such that an amino group or hydroxyl group from said biologically active antiviral compound forms a phosphate, phosphoramidate, carbonate or urethane group with the adjacent moiety; R8 is H, or a C1-C20 alkyl or ether group, preferably a C1-C12 alkyl group; k is 0-12, preferably, 0-2; R3 is selected from a C1-C4 alkyl (preferably CH3), -(CH2)n-C=C-Ra, Formula (X) or Formula (XI); R3a and R3b are independently selected from H, F, C1, Br or I; R4 and R5 are independently selected from H, F, Cl, Br, I, OH, C1-C4 alkyl (preferably CH3),-(CH2)n-C C-Ra, Formula (XII) or Formula (XIII) with the proviso that R4 and R5 are not both H; Ra is H,F,Cl,Br,I or -C1-C4 alkyl, preferably H or CH3; Y is H, F, C1, Br, I or -C1-C4 alkyl, preferably H or CH3; and n is 0,1,2,3,4 or 5, preferably 0, 1 or 2; and their anomers, pharmaceutically acceptable salts, solvates or polymorphs thereof.

Attached files:
EP 2298783.jpg

EP 2,298,783


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