Tumour-specific P450 Protein

The discovery that CYP1B1 protein is detectable in a wide range of human cancers of different histogenetic types, but is not detectable in non-cancerous tissues, gives rise to diagnostic methods for detecting tumours based on this protein as a marker, and to the possibility of tumour therapies involving the protein. A diagnostic method may include the steps of: (a) obtaining from a patient a tissue sample to be tested for the presence of cancer cells; (b) producing a prepared sample in a sample preparation process; (c) contacting the prepared sample with an antibody that reacts with human CYP1B1 protein; and (d) detecting binding of the antibody to CYP1B1 protein in the prepared sample.

Patents:
ES 2,358,106

Inventor(s): MELVIN WILLIAM THOMAS [GB]; MURRAY GRAEME IAN [GB]; BURKE MICHAEL DANNY [GB]; GREENLEE WILLIAM FRANK [US]

Type of Offer: Sale



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