Toll-Like Receptor 9 Modulators
TLR9 is localized to endoplasmic reticulum and upon stimulation with a TLR9 ligand, is transported to a tubular lysosomal compartment as is CpG-DNA. Furthermore, it is shown that TLR9 and CpG-DNA directly bind. It was also found that the MyD88 translocates in response to activation of TLR9-mediated signaling. Methods of identifying compounds that affect translocation and activity of TLR9 and MyD88 are described.
Patents:US 20,100,291,577
Inventor(s):
LATZ EICKE [US]; VISINTIN ALBERTO [US]; GOLENBOCK DOUGLAS T [US]
Type of Offer:
Sale
« More Biotech Patents