Genetic Inhibition By Double-stranded Rna
PROBLEM TO BE SOLVED: To provide a process for introducing an RNA into a living cell to inhibit gene expression of a target gene in the cell. ; SOLUTION: The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the double stranded chain region of the RNA and of a portion of the target gene are identical. The inhibition is distinguished from prior art inhibition in gene expression by antisense or triple-strand methods. ; COPYRIGHT: (C)2010,JPO&INPITPatents:
JP 2,009,291,209
Inventor(s): FIRE ANDREW; XU SIQUN; MONTGOMERY MARY K; KOSTAS STEPHEN A; TIMMONS LISA; TABARA HIROAKI; DRIVER SAMUEL E; MELLO CRAIG C
Type of Offer: Sale
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