Matrix for the production of ligaments, tendons and other tissue

The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed.

Patents:
EP 2,319,547

Inventor(s): ALTMAN GREGORY H [US]; KAPLAN DAVID L [US]; HORAN REBECCA L [US]; HORAN DAVID [US]

Type of Offer: Licensing



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