Pharmaceutical Composition Containing Cannabinoid-receptor Antagonists

The present invention relates to the use of cannabinoid-receptor 2 (CB2R)-antagonists for the prophylaxis and/or treatment of pathogen, in particular, parasitic protozoa, caused or induced cerebral diseases, disorders or conditions including secondary and accompanying diseases, disorders or conditions, like encephalitis. In a preferred embodiment, said CB2R-antagonist is a 3-pyrazole-carboxamide derivative. In a further aspect, the present invention provides pharmaceutical compositions comprising said CB2R-antagonist in combination with an anti-pathogenic active ingredient, optionally together with pharmaceutically acceptable carriers, diluents and/or excipients. Said pharmaceutical compositions are useful for treating encephalitis, like cerebral malaria induced by Plasmodium falciparum. Thus, in another aspect, methods for the treatment of pathogen, like parasitic protozoa induced or caused cerebral diseases, disorders or conditions including encephalitis, in particular cerebral malaria are provided comprising the steps of administering a CB2R-receptor antagonist.

Patents:
WO 2,011,045,068

Inventor(s): ALFERINK JUDITH [DE]; ZIMMER ANDREAS [DE]; HOERAUF ACHIM [DE]; SPECHT SABINE [DE]

Type of Offer: Sale



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