Compositions and Methods for the Inhibition of Hepatitis C Viral Replication with Structural Analogs

Compositions and methods for the inhibition of viral replication are provided. In some embodiments, the compositions include a nucleic acid sequence that is identical to a region of the hepatitis C virus (HCV) genome. In other embodiments, the compositions may include a nucleic acid sequence that has at least about 45% to about 95% sequence identity to the native HCV sequence and that has a similar secondary and tertiary structure to the native HCV sequence. In other embodiments, the compositions may include a nucleic acid sequence that does not have significant sequence identity to the native HCV sequence and that has a similar secondary and tertiary structure to the native HCV sequence. Also provided are methods for the treatment of a patient having an HCV infection by administering one of the compositions described herein, and uses of the compositions described herein in the manufacture of a medicament for the inhibition of HCV replication.

Patents:
US 20,100,260,713

Inventor(s): WU GEORGE Y [US]; WU CATHERINE H [US]; SMOLIC ROBERT [US]; SMITH ROBERT [US]

Type of Offer: Licensing



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