MicroRNAs for Modulating Herpes Virus Gene Expression

An algorithm for identification of microRNA (miRNA) targets within viral and cellular RNA is disclosed. Also disclosed are essential herpes virus genes whose transcripts contain one or more targets of miRNAs encoded by herpes viruses or by host cells as predicted by the algorithm, and the use of such targets, miRNAs and their derivatives for modulating viral replication and latency.

Patents:
US 20,090,156,535

Inventor(s): VANICEK JIRI [CH]; MURPHY EAIN [US]; ROBINS HARLAN [US]; LEVINE ARNOLD J [US]; SHENK THOMAS [US]

Type of Offer: Licensing



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