Identification of Bacterial Autoinducer and Use in Treating Bacterial Pathogenicity
A bacterial autoinducer, CAI-I, was purified and its structure identified. Methods for synthesis of the autoinducer and its analogues were elucidated. Methods of using the autoinducer or its analogues for treating bacterial pathogenicity and biofilm formation are described. Methods for prevention and treatment of cholera are described. Synthetic (iS)-3-hydroxytridecan-4-one functions as well as natural CAI-I in repressing production of the virulence factor toxin co-regulated pilus (TCP). Strategies are described to manipulate bacterial quorum sensing in the clinical arena.
BASSLER BONNIE [US]; SEMMELHACK MARTIN [US]; HIGGINS DOUGLAS A [US]; POMIANEK MEGAN A [US]; KRAML KRISTINA M [US]; NG WAI-LEUNG
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