Solubilized Topoisomerase Poisons

The invention provides compounds of formula I: wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating cancer using compounds of formula I.

Attached files:


Patents:
US 20,110,136,812

Inventor(s): LAVOIE EDMOND J [US]; RUCHELMAN ALEXANDER L [US]; LIU LEROY F [US]

Type of Offer: Licensing



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